18,811 results match your criteria Milk-Alkali Syndrome


Normocalcemic Hyperparathyroidism.

Authors:
Sabrina Corbetta

Front Horm Res 2019 19;51:23-39. Epub 2018 Nov 19.

Parathyroid hormone (PTH) disorders are characterized by a wide spectrum of clinical and biochemical presentations. The increasing use of serum PTH assay in the set of the diagnostic workout in patients with osteoporosis has identified patients with features of surgically confirmed primary hyperparathyroidism (PHPT) associated with persistent normal serum calcium levels, which has been recognized as a distinct entity from hypercalcemic PHPT (HPHPT) by the last international consensus. Normocalcemic PHPT (NPHPT) affects about 6-8% of PHPT patients. Read More

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http://dx.doi.org/10.1159/000491036DOI Listing
November 2018

Nonparathyroid Hypercalcemia.

Authors:
David Goltzman

Front Horm Res 2019 19;51:77-90. Epub 2018 Nov 19.

Primary hyperparathyroidism is among the most common causes of hypercalcemia. However, ingestion of medication, including hydrochlorathiazide, lithium, and foscarnet, excessive vitamin A ingestion, endocrinopathies such as hyperthyroidism, adrenal insufficiency, and acromegaly, abnormal nutrient intake such as parenteral nutrition in preterm infants and milk-alkali syndrome, and prolonged immobilization have all been associated with hypercalcemia. The most common cause of nonparathyroid hypercalcemia is neoplasia. Read More

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http://dx.doi.org/10.1159/000491040DOI Listing
November 2018

Parathyroid Carcinoma.

Front Horm Res 2019 19;51:63-76. Epub 2018 Nov 19.

Parathyroid carcinoma (PC) is a rare endocrine malignancy, accounting for <1% of all cases of sporadic primary hyperparathyroidism (PHPT) and up to 15% in the hereditary hyperparathyroidism-jaw tumor syndrome. Genomic alterations identified in PC are mostly represented by CDC73 gene mutations, codifying for a loss-of-function protein termed parafibromin. Whole exome sequencing identified mutations in other genes, such as mTOR, KMT2D, CDKN2C, THRAP3, PIK3CA, and EZH2 genes, CCND1 gene amplification. Read More

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http://dx.doi.org/10.1159/000491039DOI Listing
November 2018

Familial Hypocalciuric Hypercalcemia and Neonatal Severe Hyperparathyroidism.

Front Horm Res 2019 19;51:52-62. Epub 2018 Nov 19.

Familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT) are genetically determined variants of primary hyperparathyroidism. FHH usually has a benign course, and patients do not require treatment, whereas NSHPT is a severe disorder often requiring early parathyroidectomy for young patients to survive. Recent discoveries in the genetic basis and new findings in therapeutic approaches have led to a great interest in these rare diseases. Read More

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http://dx.doi.org/10.1159/000491038DOI Listing
November 2018

Familial and Hereditary Forms of Primary Hyperparathyroidism.

Front Horm Res 2019 19;51:40-51. Epub 2018 Nov 19.

Individuals with a familial predisposition to the development of parathyroid tumors constitute a small minority of all patients with primary hyperparathyroidism (PHPT). These familial syndromes exhibit Mendelian inheritance patterns and the main causative genes in most families have been identified. They include multiple endocrine neoplasia (MEN; types 1, 2A, and 4), hyperparathyroidism-jaw tumor (HPT-JT) syndrome, familial isolated hyperparathyroidism, familial hypocalciuric hypercalcemia (FHH), and neonatal severe PHPT. Read More

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https://www.karger.com/Article/FullText/491037
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http://dx.doi.org/10.1159/000491037DOI Listing
November 2018
2 Reads

Primary Hyperparathyroidism.

Authors:
Laura Masi

Front Horm Res 2019 19;51:1-12. Epub 2018 Nov 19.

The 4 parathyroid glands derive from the third and fourth pharyngeal pouches and descend caudally to the anterior neck. Through the secretion of parathyroid hormone (PTH), the parathyroid glands are primarily responsible for maintaining extracellular calcium and phosphorus concentrations. Hypercalcemia may be distinguished in parathyroid-hypercalcemia and nonparathyroid hypercalcemia. Read More

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http://dx.doi.org/10.1159/000491034DOI Listing
November 2018

A Case of Pregnancy Complicated by Primary Hyperparathyroidism Due to a Parathyroid Adenoma.

Am J Case Rep 2019 Jan 14;20:53-59. Epub 2019 Jan 14.

Laboratory of Age-Related Metabolic and Endocrine Disorders, The Russian Gerontology Clinical Research Center, Moscow, Russian Federation.

BACKGROUND Primary hyperparathyroidism is most common in women during the menopause and its occurrence in pregnant women is rare. However, because neonatal mortality is associated with maternal hyperparathyroidism, early diagnosis is essential. This report describes the case of a late diagnosis of primary hyperparathyroidism in a 28-year-old pregnant woman and describes the effects on the mother and neonate. Read More

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http://dx.doi.org/10.12659/AJCR.912436DOI Listing
January 2019

CYP24A1 Variants in Two Chinese Patients with Idiopathic Infantile Hypercalcemia.

Fetal Pediatr Pathol 2019 Jan 11:1-13. Epub 2019 Jan 11.

a Shandong Provincial Hospital Affiliated to Shandong University , Jinan , China.

Background: Biallelic pathogenic variants in CYP24A1 can cause idiopathic infantile hypercalcemia (HCINF).

Methods: We report 2 additional molecular abnormalities in 2 Chinese children with CHINF1.

Results: Biallelic variants in CYP24A1 were found in two patients. Read More

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http://dx.doi.org/10.1080/15513815.2018.1492052DOI Listing
January 2019

Vitamin D and Calcium Homeostasis in Infants with Urolithiasis.

Adv Exp Med Biol 2019 Jan 12. Epub 2019 Jan 12.

Department of Pediatrics and Nephrology, Warsaw Medical University, Warsaw, Poland.

The incidence of urolithiasis in infants is unknown. The aim of this study was to investigate clinical characteristics, nutrition, calcium, phosphate, 25-hydroxyvitamin D (25(OH)D), alkaline phosphate, and parathyroid hormone in infants with urolithiasis. There were 32 infants (23 boys and 9 girls) of the mean age of 6. Read More

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http://dx.doi.org/10.1007/5584_2018_310DOI Listing
January 2019

Upregulated osterix promotes invasion and bone metastasis and predicts for a poor prognosis in breast cancer.

Cell Death Dis 2019 Jan 10;10(1):28. Epub 2019 Jan 10.

Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Longmian Road 101, 211166, Nanjing, Jiangsu, China.

Approximately 70% of patients with advanced breast cancer develop bone metastases, accompanied by complications, such as bone pain, fracture, and hypercalcemia. However, our understanding of the molecular mechanisms that govern this process remains fragmentary. Osterix (Osx) is a zinc finger-containing transcription factor essential for osteoblast differentiation and bone formation. Read More

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http://www.nature.com/articles/s41419-018-1269-3
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http://dx.doi.org/10.1038/s41419-018-1269-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328543PMC
January 2019
2 Reads

Rapid onset of hypercalcemia from high-grade lymphoma in the setting of HIV-related immune reconstitution inflammatory syndrome.

Bone Rep 2019 Jun 28;10:100194. Epub 2018 Dec 28.

Division of Endocrinology and Metabolism, Department of Medicine, Zuckerberg San Francisco General Hospital, United States of America.

Hypercalcemia in HIV patients has been previously reported, but 1,25-(OH) vitamin D-mediated hypercalcemia, due to increased activity of extrarenal 1-alpha hydroxylase, is rarely described with HIV-related infections or malignancies. We describe a case of 1,25-(OH) vitamin D-mediated hypercalcemia in a patient presenting with progressive cognitive decline and weakness. Initial evaluation revealed a new diagnosis of HIV, for which he was started on antiretroviral therapy (ART). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23521872183006
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http://dx.doi.org/10.1016/j.bonr.2018.100194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319307PMC
June 2019
1 Read

Vitamin D Supplementation in Central Nervous System Demyelinating Disease-Enough Is Enough.

Int J Mol Sci 2019 Jan 8;20(1). Epub 2019 Jan 8.

Institute of Neuropathology, University Medical Center, 37099 Göttingen, Germany.

The exact cause of multiple sclerosis (MS) remains elusive. Various factors, however, have been identified that increase an individual's risk of developing this central nervous system (CNS) demyelinating disease and are associated with an acceleration in disease severity. Besides genetic determinants, environmental factors are now established that influence MS, which is of enormous interest, as some of these contributing factors are relatively easy to change. Read More

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http://www.mdpi.com/1422-0067/20/1/218
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http://dx.doi.org/10.3390/ijms20010218DOI Listing
January 2019
1 Read

Randomized controlled trial of vitamin D supplementation in older people to optimize bone health.

Am J Clin Nutr 2019 Jan 8. Epub 2019 Jan 8.

MRC Elsie Widdowson Laboratory, Cambridge, United Kingdom.

Background: Vitamin D insufficiency is common in older people and may lead to increased bone resorption, bone loss, and increased falls and fractures. However, clinical trials assessing the effect of vitamin D supplementation on bone mineral density (BMD) have yielded conflicting results.

Objectives: This study examined the effect of vitamin D supplementation on BMD at the hip, using dual-energy X-ray absorptiometry. Read More

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https://academic.oup.com/ajcn/advance-article/doi/10.1093/aj
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http://dx.doi.org/10.1093/ajcn/nqy280DOI Listing
January 2019
3 Reads

Subacute Gummy Vitamin Overdose as a Rare Manifestation of Child Neglect.

Pediatr Emerg Care 2019 Jan 7. Epub 2019 Jan 7.

We present a case of a 20-month-old girl who presented to the emergency department with anorexia, progressive weakness, and lethargy who was found to have severe hypercalcemia (20.7 mg/dL) and vitamin D hypervitaminosis. Further questioning revealed that this was secondary to a subacute toxic ingestion of "L'il Critters" calcium and vitamin D3 gummy vitamins that were being administered by the patient's mother multiple times a day for several weeks or even months. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001718DOI Listing
January 2019
1 Read

Parathyroid Apoplexy Following Cinacalcet Treatment in Primary Hyperparathyroidism.

Front Endocrinol (Lausanne) 2018 21;9:777. Epub 2018 Dec 21.

Unit of Endocrinology, Department of Medicine and Sciences of Aging and Ce.S.I.-Me.T., University of Chieti-Pescara, Chieti, Italy.

Cinacalcet, a calcimimetic drug, is considered a safe and valid option for the treatment of hypercalcemia in patients with primary hyperparathyroidism who are unable to undergo parathyroidectomy. Hypocalcemia and gastrointestinal adverse reactions are the main side effects reported in patients treated with cinacalcet. We present here the case of an 80-years-old patient with primary hyperparathyroidism treated with cinacalcet for 17 months who developed a severe and symptomatic episode of hypocalcemia requiring hospitalization 1 month after reaching a daily dose of 180 mg. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00777
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http://dx.doi.org/10.3389/fendo.2018.00777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308315PMC
December 2018
1 Read

Activated vitamin D3 formulations can be safely used as concomitant medication for prevention of denosumab-induced hypocalcemia in women with postmenopausal osteoporosis.

J Obstet Gynaecol Res 2019 Jan 7. Epub 2019 Jan 7.

Department of Gynecology, Yokohama City University Medical Center, Yokohama, Japan.

Aim: Denosumab prevents osteoporosis by potently inhibiting bone resorption, but requires oral therapy with calcium and vitamin D preparations to prevent the side effects of hypocalcemia. Generally, a combination drug containing calcium, natural vitamin D, and magnesium is used. However, if activated vitamin D has been used before the initiation of denosumab therapy, continued use of activated vitamin D is not uncommon. Read More

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http://doi.wiley.com/10.1111/jog.13913
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http://dx.doi.org/10.1111/jog.13913DOI Listing
January 2019
2 Reads

Follicular cell lineage in persistent ultimobranchial remnants of mammals.

Authors:
Yoko Kameda

Cell Tissue Res 2019 Jan 8. Epub 2019 Jan 8.

Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, 252-0374, Japan.

It has been a subject of much debate whether thyroid follicular cells originate from the ultimobranchial body, in addition to median thyroid primordium. Ultimobranchial remnants are detected in normal dogs, rats, mice, cattle, bison and humans and also in mutant mice such as Eya1 homozygotes, Hox3 paralogs homozygotes, Nkx2.1 heterozygotes and FRS2α. Read More

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http://link.springer.com/10.1007/s00441-018-02982-9
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http://dx.doi.org/10.1007/s00441-018-02982-9DOI Listing
January 2019
1 Read

Bone mineral density evolution and incidence of fractures in a cohort of patients with primary hyperparathyroidism treated with parathyroid surgery vs active surveillance during 6 years of follow-up.

Endocrinol Diabetes Nutr 2019 Jan 6;66(1):41-48. Epub 2018 Jul 6.

Servicio de Endocrinología, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Universidad de Cantabria, , Santander (Cantabria), España.

Introduction: The need for parathyroidectomy to treat asymptomatic patients with primary hyperparathyroidism is controversial. The aim of this study was to assess the impact of parathyroidectomy vs. surveillance on skeletal outcomes such as bone mineral density (BMD) and incident fractures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S25300164183013
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http://dx.doi.org/10.1016/j.endinu.2018.05.010DOI Listing
January 2019
2 Reads

WY 1048, a 17-methyl 19-nor D-ring analog of vitamin D, in combination with risedronate restores bone mass in a mouse model of postmenopausal osteoporosis.

J Steroid Biochem Mol Biol 2019 Jan 3. Epub 2019 Jan 3.

Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Belgium. Electronic address:

Bisphosphonates like risedronate inhibit osteoclast-mediated bone resorption and are therefore used in the prevention and treatment of osteoporosis. Also vitamin D and calcium supplementation is commonly used in the prevention or treatment of osteoporosis. Combined therapy of risedronate with 1,25(OH)D, the active metabolite of vitamin D, may be advantageous over the use of either monotherapy, but bears a risk of causing hypercalcemia thereby decreasing the therapeutic window for osteoporosis treatment. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2018.12.016DOI Listing
January 2019

Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience.

J Steroid Biochem Mol Biol 2019 Jan 3. Epub 2019 Jan 3.

Summit Behavioral Healthcare, Cincinnati, OH, 45237, United States.

Vitamin D3 is a secosteroid hormone produced in the skin in amounts estimated up to 25,000 international units (IUs) a day by the action of UVB radiation on 7-dehydrocholesterol. Vitamin D deficiency is common due to both lack of adequate sun exposure to the skin, and because vitamin D is present in very few food sources. Deficiency is strongly linked to increased risk for a multitude of diseases, several of which have historically been shown to improve dramatically with either adequate UVB exposure to the skin, or to oral or topical supplementation with vitamin D. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09600760183062
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http://dx.doi.org/10.1016/j.jsbmb.2018.12.010DOI Listing
January 2019
2 Reads

Clinical characteristics and prognosis of immunoglobulin D myeloma in the novel agent era.

Ann Hematol 2019 Jan 4. Epub 2019 Jan 4.

Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Dadao, Wuhan, 430022, China.

Immunoglobulin D (IgD) myeloma is a rare subtype that used to lead to a poor outcome. To investigate the current clinical features, cytogenetic changes and survival of patients with IgD myeloma under novel treatments, we analysed 47 patients with IgD myeloma, 31 men and 16 women, with a median age of 54.5 years. Read More

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http://link.springer.com/10.1007/s00277-018-3582-4
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http://dx.doi.org/10.1007/s00277-018-3582-4DOI Listing
January 2019
2 Reads

Two Different Causes of Paediatric Hypercalcaemia.

Sultan Qaboos Univ Med J 2018 Aug 19;18(3):e389-e392. Epub 2018 Dec 19.

Department of Otorhinolaryngology, Pardubice Hospital, Pardubice, Czech Republic.

Paediatric hypercalcaemia is a rare condition which can be easily overlooked or misdiagnosed. We report two paediatric patients who presented to the Department of Paediatrics, Pardubice Hospital, Pardubice, Czech Republic, in 2009 and 2010, respectively. Each patient was diagnosed with hypercalcaemia due to a different cause. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307649PMC
August 2018
1 Read

Clinical and translational pharmacology of drugs for the prevention and treatment of bone metastases and cancer-induced bone loss.

Br J Clin Pharmacol 2019 Jan 2. Epub 2019 Jan 2.

Oncology Division, Hospital de Santa Maria - CHLN, Lisbon, Portugal; 2 Luis Costa Lab, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.

Bone disease is a frequent event in cancer patients, both due to cancer spread to bone and to cancer therapies. Bone is the organ most frequently affected by metastatic disease when considering the two most frequent cancers in the western world (breast and prostate cancers). Bone metastases can have a substantial detrimental effect on patients' quality of life, as well as significant morbidity due to complications collectively known as skeletal-related events (SREs), which include hypercalcemia, pathological fractures, spinal cord compression, and need of radiotherapy or surgery to the bone. Read More

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http://dx.doi.org/10.1111/bcp.13852DOI Listing
January 2019
1 Read

Idiopathic Hypoparathyroidism and Severe Hypocalcemia in Pregnancy.

Case Rep Endocrinol 2018 27;2018:8316017. Epub 2018 Nov 27.

Department of Endocrinology, Rafic El Hariri University Hospital, Beirut, Lebanon.

The objective of this study is to report a case of severe hypocalcemia secondary to hypoparathyroidism in a pregnant woman. We report a case of a 45-year-old woman who presented for tonico-clonic seizure in the third trimester of gestation. She was diagnosed with idiopathic hypoparathyroidism for the first time during pregnancy. Read More

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http://dx.doi.org/10.1155/2018/8316017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288569PMC
November 2018

The Relationship between Primary Hyperparathyroidism and Thrombotic Events: Report of Three Cases and a Review of Potential Mechanisms.

Int J Hematol Oncol Stem Cell Res 2018 Jul;12(3):175-180

Division of Endocrinology and Metabolism, Diabetes Center, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.

We have described three uncommon cases of patients who presented with clinical thrombotic events (stroke, pulmonary embolism and deep venous thrombosis) during the course of a hypercalcemia-induced hypercoagulable state. After thorough investigation, the diagnosis of primary hyperparathyroidism - due to a parathyroid adenoma - was established in all cases. The association between hypercalcemia and venous or arterial thrombosis has been previously described; however, relevant data are still insufficient. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305263PMC

Treatment Effect of Ergocalciferol on Bone Metabolism Indexes and Parathyroid Hormone in Hemodialysis Patients.

Iran J Kidney Dis 2018 Nov;12(6):359-363

Department of Internal Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Introduction: Vitamin D deficiency is a common problem in end-stage renal disease patients under hemodialysis. Both active and nutritional vitamin D supplementation have been recommended for its treatment. In this study we aimed to evaluate the effects of treatment with ergocalciferol on bone metabolism indexes in hemodialysis patients. Read More

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November 2018

Traitement des métastases osseuses du cancer du rein.

Bull Cancer 2018 Dec;105 Suppl 3:S268-S279

Département d'oncologie médicale, Gustave Roussy, Villejuif, France.. Electronic address:

Treating Patients With Bone Metastases From Renal Cell Carcinoma: Bone metastases (BMs) are common and cause morbidity in cancer patients. One third of metastatic renal cancer (mRCC) patients present metastatic disease to the bone. BMs cause severe complications such as fracture, spinal cord compression and pain requiring surgery or radiotherapy. Read More

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http://dx.doi.org/10.1016/S0007-4551(18)30382-5DOI Listing
December 2018
1 Read

Juvenile onset IIH and mutations.

Bone Rep 2018 Dec 21;9:42-46. Epub 2018 Jun 21.

Department of General Pediatrics, University Children's Hospital, Münster, Germany.

The term Idiopathic infantile hypercalcemia (IIH) was first introduced almost 70 years ago when symptomatic hypercalcemia developed in children after receiving high doses of vitamin D for the prevention of rickets. The underlying pathophysiology remained unknown until recessive mutations in encoding Vitamin D-24-hydroxylase were discovered. The defect in vitamin D degradation leads to an accumulation of active 1,25(OH)D with subsequent hypercalcemia. Read More

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http://dx.doi.org/10.1016/j.bonr.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303532PMC
December 2018
1 Read

Discovery of novel nonsteroidal VDR agonists with novel diarylmethane skeleton for the treatment of breast cancer.

Eur J Med Chem 2019 Feb 14;163:787-803. Epub 2018 Dec 14.

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of New Drug Discovery, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, China. Electronic address:

Vitamin D receptor (VDR) is recognized as a potential target for the treatment of breast cancer which is the most common malignancy among women in the world. In this study, a series of nonsecosteroidal VDR agonists with a novel diarylmethane skeleton was designed, synthesized and the anti-tumor activities of these compounds were determined. Compound 28 was identified as the most effective agents in reducing the viability of MCF-7 cells, with a low IC via the inhibition of cell cycle and induction of apoptosis by regulating the expression of p21, Bcl2 and Bax. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183106
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http://dx.doi.org/10.1016/j.ejmech.2018.12.024DOI Listing
February 2019
6 Reads

The discovery and synthesis of the nutritional factor vitamin D.

Authors:
Glenville Jones

Int J Paleopathol 2018 Dec 17;23:96-99. Epub 2018 Jan 17.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada. Electronic address:

Although vitamin D deficiency was first recognized as rickets/osteomalacia in the early 1600s, it was only a century ago that vitamin D, the nutritional factor responsible, was discovered. This discovery was made difficult by the fact that the substance could be synthesized in human skin by exposure to UV light and could also be present in the diet in animal-derived (D) and plant-derived forms (D). Prior to 1920, the frequency of vitamin D deficiency in the general population of industrialized cities was high. Read More

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http://dx.doi.org/10.1016/j.ijpp.2018.01.002DOI Listing
December 2018
1 Read

Acute hypercalcemia and excessive bone resorption following anti-RANKL withdrawal: Case report and brief literature review.

Bone 2018 Dec 17;120:482-486. Epub 2018 Dec 17.

Department of Medicine, Division of Hemato-Oncology, Faculty of Medicine and Health Sciences, University of Sherbrooke, PQ, Canada.

Denosumab is an anti-RANKL antibody that is commonly used for the treatment of osteoporosis; in oncology, bisphosphonates and denosumab have become the standard therapies for the treatment and prevention of skeletal complications in patients with myeloma and solid tumors. In recent years, excessive bone remodeling following the discontinuation of denosumab has raised concerns. Several cases of hypercalcemia have been reported after the discontinuation of high-dose denosumab (120 mg every 4 weeks), mainly in children. Read More

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http://dx.doi.org/10.1016/j.bone.2018.12.012DOI Listing
December 2018
2 Reads

Successful Treatment of Tuberculosis-Associated Hypercalcemia with Denosumab in a Patient with Acute Kidney Injury.

Ther Apher Dial 2018 Dec 19. Epub 2018 Dec 19.

University of Mississippi Medical Center - Internal Medicine, 2500 N State St Jackson Mississippi, 39216-4505, United States.

Denosumab is FDA approved for the treatment of osteoporosis in post-menopausal women at high risk of fracture. Other indications include bone loss in patient with prostate or breast cancer undergoing ablation therapy, hypercalcemia from malignancy and more recently it was approved for glucocorticoid-induced osteoporosis (1, 2). To our knowledge, we present the first case of successful treatment of tuberculosis (TB)-associated hypercalcemia with denosumab. Read More

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http://dx.doi.org/10.1111/1744-9987.12788DOI Listing
December 2018
1 Read

A Rare Presentation of Hypermagnesemia Associated with Acute Kidney Injury due to Hypercalcemia.

Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Japan.

A 79-year-old Japanese woman presented with consciousness disturbance, hypercalcemia, and hypermagnesemia. She had rheumatoid arthritis and osteoporosis. Three months before admission, she was treated with oral calcitriol for osteoporosis. Read More

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http://dx.doi.org/10.2169/internalmedicine.1927-18DOI Listing
December 2018

Parathyroid Lipoadenoma: A Pitfall in Preoperative Localization.

Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.1249-18DOI Listing
December 2018
1 Read

Cognitive decline due to ectopic primary hyperparathyroidism.

Clin Case Rep 2018 Dec 5;6(12):2513-2514. Epub 2018 Nov 5.

Department of General Medicine, Dentistry and Pharmaceutical Sciences Okayama University Graduate School of Medicine Okayama Japan.

When you see a patient with cognitive dysfunction, hypercalcemia due to hyperparathyroidism is an important differential diagnosis. It is important to consider including chest computed tomography and I-MIBI SPECT examinations in patients with possible hyperparathyroidism and normal thyroid ultrasound. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.1901
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http://dx.doi.org/10.1002/ccr3.1901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293175PMC
December 2018
2 Reads

Pharmacokinetics of intra-articular vitamin D analogue calcipotriol in sheep and metabolism in human synovial and mesenchymal stromal cells.

J Steroid Biochem Mol Biol 2018 Dec 15. Epub 2018 Dec 15.

Cancer Research and Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O.Box 8000 FI-90014, University of Oulu, Oulu, Finland; Rheumatology Unit, Department of Medicine, Oulu University Hospital and University of Oulu, MRC, Oulu, P.O. Box 10, 90029 OYS, Finland. Electronic address:

Calcipotriol (MC903) is a side chain analogue of the biologically active 1,25-dihydroxyvitamin D [1,25(OH)D]. Due to its anti-inflammatory and anti-proliferative effects on stromal cells, calcipotriol is a promising candidate for the local treatment of arthritis. In this preliminary work, we studied the pharmacokinetics and safety of calcipotriol after an IV (0. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2018.12.006DOI Listing
December 2018
1 Read

Myoclonus and hypercalcemia in a dog with poorly differentiated lymphoproliferative neoplasia.

J Vet Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Queen's Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.

A 1-year, 8-month-old Rhodesian Ridgeback was presented with obtundation, ambulatory tetraparesis, and myoclonus. Initial clinical findings included ionized hypercalcemia with an apparent marked increase in parathyroid hormone, thrombocytopenia, and nonregenerative anemia. Low numbers of circulating atypical cells were noted on blood film evaluation. Read More

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http://dx.doi.org/10.1111/jvim.15398DOI Listing
December 2018
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Chronic Urticaria and Osteoporosis: A longitudinal, Community-based Cohort Study of 11,944 Patients.

Br J Dermatol 2018 Dec 18. Epub 2018 Dec 18.

Siaal Research Center for Family Medicine and Primary Care, Division of Community Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: Chronic urticaria (CU) carries many risk factors for osteoporosis, but data on the relation between CU and osteoporosis are lacking.

Objective: To evaluate the association between CU and osteoporosis in a large community-based study.

Methods: A nationwide observational longitudinal cohort study was conducted. Read More

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http://dx.doi.org/10.1111/bjd.17528DOI Listing
December 2018
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Severe hypercalcemia in a patient with extrapulmonary : granuloma or immune reconstitution inflammatory syndrome? First case of presenting as retroperitoneal lymphadenopathy with severe hypercalcemia: a case report and literature review.

J Community Hosp Intern Med Perspect 2018 11;8(6):331-338. Epub 2018 Dec 11.

Medicine Department, Pulmonary and Critical Care Division, Interfaith Medical Center, Brooklyn, NY, USA.

Nontuberculous mycobacterium is a recognized cause of hypercalcemia, particularly in patients with acquired immunodeficiency syndrome (AIDS). Here we describe a case of severe hypercalcemia secondary to () in a patient with AIDS. To the best of our knowledge this is the first case report describing a case of presenting as retroperitoneal lymphadenopathy and severe hypercalcemia. Read More

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http://dx.doi.org/10.1080/20009666.2018.1539057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292348PMC
December 2018

Lupus pernio (Besnier-Tenneson syndrome): A rare form of sarcoidosis.

Dermatol Reports 2018 Oct 1;10(2):7696. Epub 2018 Oct 1.

Hospital of Skin and Venereal Disease Hospital named after VA Rakhmanov. I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

Lupus pernio (LP) is a chronic non-life threatining type of cutaneous sarcoidosis that can be related to chronic fibrotic sarcoidosis, hyperglobulinemia and hypercalcemia. The aim of this case report is to evaluate the clinical and demographic features of cutaneous sarcoidosis mainly presenting with a rare manifestation of LP. In this paper we report a case of systemic sarcoidosis presenting with LP and a review of the available literature. Read More

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http://dx.doi.org/10.4081/dr.2018.7696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250080PMC
October 2018
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Efficacy of calcium excretion and calcium/creatinine clearance ratio in the differential diagnosis of familial hypocalciuric hypercalcemia and primary hyperparathyroidism.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.

Background: Twenty-four-hour renal calcium-excretion (CE) and calcium/creatinine-clearance-ratio (CCCR), respectively, are widely used to rule out familial hypocalciuric hypercalcemia (FHH) in patients with suspected primary hyperparathyroidism before surgery. The aim was to evaluate the practicability of CE compared to CCCR.

Patients And Methods: We analyzed biochemical parameters, surgical treatment, gene mutation results, and long-term follow-up data of 198 patients (including 14 patients with FHH) and the discriminative power of CE and CCCR. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25568
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http://dx.doi.org/10.1002/hed.25568DOI Listing
December 2018
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Efficacy and Safety of 22-Oxa-Calcitriol in Patients with Rheumatoid Arthritis: A Phase II Trial.

Med Sci Monit 2018 Dec 16;24:9127-9135. Epub 2018 Dec 16.

Department of Neurology Intensive Care Unit, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China (mainland).

BACKGROUND Calcitriol (1 alpha, 25-dihydroxy vitamin D3) is a good vitamin D supplement but can cause hypercalcemia. Whereas, 22-oxa-1 alpha, 25-dihydroxy vitamin D3 (22-oxa-calcitriol) has less hypercalcemic activity than calcitriol and is reported to be effective for cell-proliferative diseases. The objective of the study was to compare renal function and blood tests of arthritis patients receiving calcitriol supplements with those receiving 22-oxa-calcitriol supplements. Read More

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http://dx.doi.org/10.12659/MSM.911628DOI Listing
December 2018

Calcioic acid: In vivo detection and quantification of the terminal C24-oxidation product of 25-hydroxyvitamin D and related intermediates in serum of mice treated with 24,25-dihydroxyvitamin D.

J Steroid Biochem Mol Biol 2018 Dec 13. Epub 2018 Dec 13.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. Electronic address:

Calcitroic acid, the excretory form of vitamin D, is the terminal product of a 5-step pathway catalyzed by CYP24A1, commencing with C24-hydroxylation of 1,25-dihydroxyvitamin D (1,25-(OH)D). Catabolism of 25-hydroxyvitamin D (25-OH-D) proceeds via analogous steps culminating in calcioic acid; however this C23-truncated acid has not been reported in the circulation. It has recently been shown that 24,25-dihydroxyvitamin D (24,25-(OH)D) is an important factor in optimal bone fracture healing acting via an effector molecule FAM57B2 to produce lactosylceramide. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2018.12.001DOI Listing
December 2018

Modification of the bone marrow MSC population in a xenograft model of early multiple myeloma.

Biochem Biophys Res Commun 2019 Jan 13;508(4):1175-1181. Epub 2018 Dec 13.

Cancer Science Institute of Singapore, Centre for Translational Medicine, National University of Singapore, 14 Medical Drive, #12-01, 117599, Singapore; International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City, 860-0811, Japan. Electronic address:

Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of abnormal plasma cells. MM dysregulates the homeostasis of the bone niche cells like osteoclasts and osteoblasts, responsible for the bone maintenance leading to bone loss and hypercalcemia, as well as the normal immune cells leading to immunodeficiency and anemia. Osteoblasts are part of the cell population differentiating from mesenchymal stem cells (MSC). Read More

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http://dx.doi.org/10.1016/j.bbrc.2018.11.178DOI Listing
January 2019
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Randomized trial of three doses of vitamin D to reduce deficiency in pregnant Mongolian women.

EBioMedicine 2018 Dec 11. Epub 2018 Dec 11.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Boston, USA. Electronic address:

Background: In winter in Mongolia, 80% of adults have 25-hydroxyvitamin D (25(OH)D) concentrations <25 nmol/l (<10 ng/ml) and 99% have <50 nmol/l (<20 ng/ml). The vitamin D dose to avert deficiency during pregnancy in this population is unknown.

Methods: We conducted a randomized, controlled, double-blind trial of daily 600, 2000, or 4000 IU vitamin D for pregnant women in Mongolia (Clinicaltrials. Read More

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http://dx.doi.org/10.1016/j.ebiom.2018.11.060DOI Listing
December 2018

Parathyroid carcinoma.

Best Pract Res Clin Endocrinol Metab 2018 Dec 1. Epub 2018 Dec 1.

Departments of Laboratory Medicine and Pathobiology, Medicine and Genetics, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Parathyroid carcinoma (PC) is a rare disease with an indolent behavior due to the low malignant potential. The etiology is unknown. Somatic mutations of CDC73 gene, the same gene involved in the hyperparathyroidism-jaw tumor syndrome, can be identified in up to 70% of patients with PC and in one-third of cases the mutations are germline. Read More

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http://dx.doi.org/10.1016/j.beem.2018.11.002DOI Listing
December 2018
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Two Cases of Hypercalcemia in Pediatric Ovarian Dysgerminoma.

J Obstet Gynaecol Can 2018 Dec 12. Epub 2018 Dec 12.

Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, MB.

Objective: To discuss the finding of hypercalcemia in pediatric ovarian dysgerminoma.

Methods: Two cases of pediatric ovarian dysgerminoma that presented with hypercalcemia are discussed.

Results: Hypercalcemia is a rare finding in ovarian dysgerminoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17012163183039
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http://dx.doi.org/10.1016/j.jogc.2018.05.004DOI Listing
December 2018
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[Parathyroid carcinoma: diagnosis by a femur fracture].

Acta Ortop Mex 2018 Jul-Aug;32(4):229-233

Departamento de Anatomopatología del Hospital Ángeles León. León, Guanajuato. México.

Background: Carcinoma of the parathyroid gland (PC) described by De Quervain since 1909, it represents the least common neoplasm, with an incidence of 1,25/10,000,000 peoples. It has been reported approximately 1,000 cases of CP in world literature. There are two series in Mexico, one of eight patients and other with four cases. Read More

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December 2018
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Hypercalcemia and Psychosis: Case Report, Review of the Literature, and Management Considerations.

Prim Care Companion CNS Disord 2018 Nov 29;20(6). Epub 2018 Nov 29.

VA Boston Healthcare System, Brockton, Massachusetts, USA.

The objective of this article is to help clinicians make an accurate diagnosis by considering hypercalcemia as a potential cause of psychosis. A patient case is presented, along with a review of the literature dissecting the association between calcium and psychiatric symptoms. Clinical implications and suggestions for management of hypercalcemia and psychosis in the setting of primary hyperparathyroidism are provided. Read More

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http://dx.doi.org/10.4088/PCC.18nr02356DOI Listing
November 2018