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    Association of Hypercalcemia Before Treatment With Hypocalcemia After Treated in Dogs With Primary Hyperparathyroidism.
    J Vet Intern Med 2017 Feb 18. Epub 2017 Feb 18.
    Department of Medicine and Epidemiology, University of California, Davis, CA.
    Background: Development of hypocalcemia after treatment of hyperparathyroidism results in increased costs and risk of poorer outcomes. Previous studies have shown conflicting data about predictors of hypocalcemia after these procedures.

    Hypothesis/objectives: The objective of this study was to investigate whether ionized calcium (iCa) concentrations before treatment are predictive of hypocalcemia or its clinical signs after surgical removal or heat ablation in dogs with primary hyperparathyroidism. Read More

    ST elevation due to hypercalcemia - Case report and review of the literature.
    Am J Emerg Med 2017 Feb 6. Epub 2017 Feb 6.
    Department of Emergency Medicine, Alameda Health System - Highland, Hospital, Oakland, CA, United States.
    Characteristic ECG changes with hypercalcemia include shortening of the QoT, QaT, and QeT intervals which are measured from the beginning of the QRS complex to the origin (O), apex (A), and end (E) of the T wave respectively. At very high serum calcium levels ECG changes include slight prolongation of the PR and QRS intervals, T wave flattening or inversion, and the appearance of a J wave at the end of the QRS complex. We present a case of a 22year-old male, who had been bedbound for 5months following a severe motor vehicle collision, presenting with shortening of the QoT and QaT intervals leading to anterior ST elevation mimicking acute myocardial infarction. Read More

    Optimizing current and emerging therapies in multiple myeloma: a guide for the hematologist.
    Ther Adv Hematol 2017 Feb 9;8(2):55-70. Epub 2016 Dec 9.
    Professor of Medicine, Director, Multiple Myeloma and Amyloidosis Service, Columbia University Medical Center, Herbert Irving Pavilion, R 953, 161 Ft. Washington Ave, New York, NY 10032, USA.
    Multiple myeloma (MM) is the second most common hematologic malignancy. The diagnosis of MM requires ⩾10% clonal plasma cells in the bone marrow or biopsy-proven plasmacytoma, plus evidence of end-organ damage (hypercalcemia, renal failure, anemia, and lytic bone lesions). The definition of MM has recently been expanded to include a ⩾60% clonal plasma cell burden in the bone marrow, serum involved/uninvolved light chain ratio of ⩾100, or more than one focal lesion on magnetic resonance imaging ⩾5 mm in the absence of end-organ damage. Read More

    Richter's Syndrome with Hypercalcemia Induced by Tumor-Associated Production of Parathyroid Hormone-Related Peptide.
    Case Rep Oncol 2017 Jan-Apr;10(1):123-126. Epub 2017 Jan 27.
    Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
    Humoral hypercalcemia due to parathyroid hormone-related peptide (PTHrP) elevation is a well-known complication of various malignancies, but the situation is rare concerning hematological malignancies except for adult T-cell leukemia/lymphoma. We report a case of Richter's syndrome with humoral hypercalcemia, and demonstrate by reverse transcription polymerase chain reaction (RT-PCR) that peripheral blood PTHrP levels were 2,500-fold higher compared to healthy controls. PTHrP production by tumor cells in chronic lymphocytic leukemia (CLL) and Richter's syndrome has been previously demonstrated by nonquantitative methods such as immunohistochemistry and northern blot analysis, but this is the first report using the RT-PCR method. Read More

    Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement.
    BMC Cancer 2017 Feb 13;17(1):128. Epub 2017 Feb 13.
    Department of Hematology and Oncology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
    Background: Skeletal involvement (SI) is observed at low prevalence in patients with diffuse large B-cell lymphoma (DLBCL). Due to the rareness of this particular condition, prospective trials for these patients are scarce.

    Methods: We analyzed clinical characteristics and outcome of 75 patients with DLBCL and SI in order to identify factors with prognostic impact towards progression-free survival (PFS) and overall survival (OS). Read More

    Chronic Kidney Disease in Cats and the Risk of Total Hypercalcemia.
    J Vet Intern Med 2017 Feb 12. Epub 2017 Feb 12.
    Department of Clinical Science and Services, Royal Veterinary College, University of London, North Mymms, Hatfield, Hertfordshire, UK.
    Background: Chronic kidney disease (CKD) is a common comorbidity in cats with hypercalcemia, but whether CKD is a risk factor for hypercalcemia is unclear. Hypercalcemia often is diagnosed based on total calcium concentration (tCa), which tends to underestimate the ionized calcium concentration (iCa) in cats.

    Objectives: Assessment of the performance of tCa for the diagnosis of ionized hypercalcemia, and exploration of factors influencing the relationship between iCa and tCa. Read More

    Multiple Myeloma, Version 3.2017, NCCN Clinical Practice Guidelines in Oncology.
    J Natl Compr Canc Netw 2017 Feb;15(2):230-269
    Multiple myeloma (MM) is caused by the neoplastic proliferation of plasma cells. These neoplastic plasma cells proliferate and produce monoclonal immunoglobulin in the bone marrow causing skeletal damage, a hallmark of multiple myeloma. Other MM-related complications include hypercalcemia, renal insufficiency, anemia, and infections. Read More

    Bisphosphonate-Related Osteonecrosis and Metastasis Within the Same Site of the Jaw.
    J Oral Maxillofac Surg 2017 Jan 18. Epub 2017 Jan 18.
    Maxillofacial Surgeon, Department of Odontostomatologic Sciences, Section of Maxillofacial Surgery, Sapienza University, Rome, Italy.
    Bisphosphonates (BPs) bind selectively to hydroxyapatite and accumulate in sites of active bone remodeling, where they inhibit bone turnover by interfering with osteoclastic recruitment, activity, and survival. For this reason, they are used in oncologic patients to prevent, decrease, and delay potentially life-threatening skeletal-related complications associated with multiple myeloma (MM) and metastasis, including hypercalcemia, pain, and pathologic fractures. Despite substantial benefits, treatment with BPs can be associated with the development of osteonecrosis of the jaw (ONJ), a pathologic condition for which pathophysiologic mechanisms are not completely defined and current criteria for prevention, diagnosis, and management are based largely on expert recommendations and guidelines. Read More

    Efficacy of vitamin D3 supplementation in reducing incidence of pulmonary tuberculosis and mortality among HIV-infected Tanzanian adults initiating antiretroviral therapy: study protocol for a randomized controlled trial.
    Trials 2017 Feb 10;18(1):66. Epub 2017 Feb 10.
    Department of Global Health and Population, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Building I Room 1104C, Boston, MA, 02115, USA.
    Background: HIV-infected adults initiating antiretroviral therapy (ART) in sub-Saharan Africa continue to experience high rates of morbidity and mortality during the initial months of treatment. Observational studies in high-income and resource-limited settings indicate that HIV-infected adults with low vitamin D levels may be at increased risk of mortality, HIV disease progression, and incidence of pulmonary tuberculosis (TB). As a result, vitamin D3 supplementation may improve survival and treatment outcomes for HIV-infected adults initiating ART. Read More

    Pure Red Cell Aplasia Associated with Monoclonal Gammopathy of Undetermined Significance and Literature Review.
    Clin Lab 2017 Feb;63(2):373-378
    Background: Pure red cell aplasia (PRCA) is an uncommon disease which involves an almost complete absence of the erythroid lineage in bone marrow (BM) and causes severe anemia. Cases due to monoclonal gammopathy occurring in plasma cell disorder have been infrequently reported. Here we report a case of PRCA associated plasma cell disorder, especially monoclonal gammopathy of undetermined significance (MGUS). Read More

    Elemental calcium intake associated with calcium acetate/calcium carbonate in the treatment of hyperphosphatemia.
    Drugs Context 2017 20;6:212302. Epub 2017 Jan 20.
    Shire Pharmaceuticals, Lexington, MA, USA.
    Background: Calcium-based and non-calcium-based phosphate binders have similar efficacy in the treatment of hyperphosphatemia; however, calcium-based binders may be associated with hypercalcemia, vascular calcification, and adynamic bone disease.

    Scope: A post hoc analysis was carried out of data from a 16-week, Phase IV study of patients with end-stage renal disease (ESRD) who switched to lanthanum carbonate monotherapy from baseline calcium acetate/calcium carbonate monotherapy. Of the intent-to-treat population (N=2520), 752 patients with recorded dose data for calcium acetate (n=551)/calcium carbonate (n=201) at baseline and lanthanum carbonate at week 16 were studied. Read More

    Liver-Directed Embolization for the Long-Term Control of Hypercalcemia of Malignancy in Metastatic Breast Cancer.
    Cancer Control 2017 Jan;24(1):57-59
    Department of Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center and Division of Oncologic Sciences, University of South Florida Morsani College of Medicine, Tampa, FL.
    Hypercalcemia of malignancy is a common complication of certain types of cancers. No standard therapies exist for the treatment of hypercalcemia secondary to paraneoplastic syndromes that result in the long-term control of serum calcium levels. We report a case of metastatic breast cancer with parathyroid hormone-related protein associated with hypercalcemia of malignancy that was treated with transarterial embolization of the hepatic metastatic lesions. Read More

    Stepwise CaSR, AP2S1, and GNA11 sequencing in patients with suspected familial hypocalciuric hypercalcemia.
    Endocrine 2017 Mar 7;55(3):741-747. Epub 2017 Feb 7.
    Department of Genetics and Metabolic diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
    Purpose: Patients with familial hyperparathyroidism and low urinary calcium excretion may have familial hypocalciuric hypercalcemia (FHH) with mutations in one of three genes: the calcium-sensing receptor (CaSR) defining FHH-type 1, the adaptor-related protein complex 2 (AP2S1) related to FHH-type 3 or the G-protein subunit alpha11 (GNA11) associated with FHH-type 2. We aimed to evaluate the presence of mutations in these genes and to identify phenotypic specificities and differences in these patients.

    Subjects And Methods: Selected patients were recruited for genetic evaluation. Read More

    Application of vitamin D and vitamin D analogs in acute myelogenous leukemia.
    Exp Hematol 2017 Feb 4. Epub 2017 Feb 4.
    Division of Hematology/Oncology, Loma Linda University School of Medicine, 11175 Campus Street, Chan Shun Pavilion 11015, Loma Linda, CA 92354, USA.
    Acute myeloid leukemia (AML) is characterized by the accumulation of malignant transformed immature hematopoietic myeloid precursors that have lost their ability to differentiate and proliferate normally. Current treatment for acute myeloid leukemia (AML) requires intensive cytotoxic chemotherapy and results in significant morbidity and mortality, especially in older patients. Effective and better-tolerated treatment is urgently needed. Read More

    Hypercalcemia of Malignancy in Thymic Carcinoma: Evolving Mechanisms of Hypercalcemia and Targeted Therapies.
    Case Rep Endocrinol 2017 12;2017:2608392. Epub 2017 Jan 12.
    Division of Endocrinology and Metabolism, Rush University Medical Center, Chicago, IL, USA.
    Here we describe, to our knowledge, the first case where an evolution of mechanisms responsible for hypercalcemia occurred in undifferentiated thymic carcinoma and discuss specific management strategies for hypercalcemia of malignancy (HCM). Case Description. We report a 26-year-old male with newly diagnosed undifferentiated thymic carcinoma associated with HCM. Read More

    A Medical Mystery: Unexplained Renal Failure in Burn Patients.
    J Burn Care Res 2017 Jan 31. Epub 2017 Jan 31.
    From the *The University of Virginia School of Medicine, Charlottesville; and †Department of Plastic, Reconstructive and Maxillofacial Surgery, University of Virginia, Charlottesville.
    The objective of this study was to review the investigation that uncovered the medical mystery of burn patients developing unexpected renal failure. The authors examined published and unpublished manuscripts and case reports, as well as conducted personal interviews with primary sources. In the late 1970s, emergence of resistant bacterial strains to the topical antimicrobial silver sulfadiazine occurred at the University of Virginia Medical Center. Read More

    Epigenetic Alterations in Parathyroid Cancers.
    Int J Mol Sci 2017 Feb 1;18(2). Epub 2017 Feb 1.
    Endocrinology Unit, Department of Biomedical Sciences for Health, University of Milan, IRCCS Istituto Ortopedico Galeazzi, 20097 Milan, Italy.
    Parathyroid cancers (PCas) are rare malignancies representing approximately 0.005% of all cancers. PCas are a rare cause of primary hyperparathyroidism, which is the third most common endocrine disease, mainly related to parathyroid benign tumors. Read More

    Two Cases of Mistaken Polyuria and Nephrocalcinosis in Infants with Glucose-Galactose Malabsorption: A Possible Role of 1,25(OH)2D3
.
    Horm Res Paediatr 2017 Feb 2. Epub 2017 Feb 2.
    Background/aims: Glucose-galactose malabsorption (GGM) is a rare and potentially fatal disorder. The autosomal recessive mutation of the SGLT1 gene interferes with the active glucose transport in the gut resulting in osmotic diarrhea and failure to thrive (FTT). Two nonrelated infants with GGM are presented as well as a novel mutation in SGLT1. Read More

    Metabolic toxicities in patients undergoing treatment for nonhematological malignancy: A cross-sectional study.
    Indian J Med Paediatr Oncol 2016 Oct-Dec;37(4):256-259
    Department of Radiation Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
    Objectives: The objective of this study was to evaluate the prevalence of metabolic toxicities in patients with different nonhematological malignancies admitted in oncology ward of a tertiary cancer care center while on treatment.

    Methods: We did this cross-sectional study over a period of 7 months (January-July 2013) for all adult patients (n = 280) who, while undergoing anti-cancer therapy at our center, got admitted to our oncology inpatient ward with metabolic toxicity. Grading of toxicity was done using National Cancer Institute Common Terminology Criteria for Adverse Events Version 4. Read More

    Hypercalcemia induces targeted autophagic degradation of aquaporin-2 at the onset of nephrogenic diabetes insipidus.
    Kidney Int 2017 Jan 27. Epub 2017 Jan 27.
    Systems Biology Center, Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Epithelial Systems Biology Laboratory, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA. Electronic address:
    Hypercalcemia can cause renal dysfunction such as nephrogenic diabetes insipidus (NDI), but the mechanisms underlying hypercalcemia-induced NDI are not well understood. To elucidate the early molecular changes responsible for this disorder, we employed mass spectrometry-based proteomic analysis of inner medullary collecting ducts (IMCD) isolated from parathyroid hormone-treated rats at onset of hypercalcemia-induced NDI. Forty-one proteins, including the water channel aquaporin-2, exhibited significant changes in abundance, most of which were decreased. Read More

    Congenital Mesoblastic Nephroma Presenting With Refractory Hypertension in a Premature Neonate: A Case Study.
    Neonatal Netw 2017 Jan;36(1):32-39
    The most common nonencapsulated solid renal tumor in the neonatal period is congenital mesoblastic nephroma. Mesoblastic nephroma is a solid lesion originating within or extending from the renal parenchyma. These tumors proliferate rapidly, typically within 3-6 months after birth. Read More

    Polyamines preserve connexin 43-mediated gap junctional communication during intracellular hypercalcemia and acidosis.
    Neuroreport 2017 Mar;28(4):208-213
    Departments of aBiochemistry bPhysiology cAnatomy and Cell Biology, School of Medicine, Universidad Central del Caribe, Bayamón, Puerto Rico dDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, New York, USA eInstitute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Changes in the regulation, formation, and gating of connexin-based gap junction channels occur in various disorders. It has been shown that H and Ca are involved in the regulation of gap junctional communication. Ischemia-induced intracellular acidification and Ca overload lead to closure of gap junctions and inhibit an exchange by ions and small molecules throughout the network of cells in the heart, brain, and other tissues. Read More

    [An Autopsy Case of an Elderly Patient with Signet-Ring Cell Carcinoma of the Breast Derived from Lobular Carcinoma].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2246-2248
    Dept. of Surgery, Fuchu Hospital.
    A 90-year-old woman was referred to our hospital because of abdominal distension and pretibial edema. No tumors were palpable in either breast. Her abdomen was distended and palpitation was noticed. Read More

    Primary Hyperparathyroidism: Effects on Bone Health.
    Endocrinol Metab Clin North Am 2017 Mar 14;46(1):87-104. Epub 2016 Dec 14.
    Section of Endocrine Surgery, UCLA David Geffen School of Medicine, 10833 Le Conte Avenue, 72-250 CHS, Los Angeles, CA 90095, USA. Electronic address:
    Primary hyperparathyroidism (PHPT) is the most common cause of chronic hypercalcemia. With the advent of routine calcium screening, the classic presentation of renal and osseous symptoms has been largely replaced with mild, asymptomatic disease. In hypercalcemia caused by PHPT, serum parathyroid hormone levels are either high, or inappropriately normal. Read More

    Prognostic Benefit of Surgical Management of Renal Cell Carcinoma Invading the Inferior Vena Cava.
    Indian J Surg Oncol 2017 Mar 4;8(1):14-18. Epub 2016 May 4.
    Athens University Medical School, Attikon University Hospital, Chaidari, Athens Greece.
    Renal cell carcinoma (RCC) accounts for approximately 3 % of adult malignancies and 90-95 % of neoplasms arising from the kidney. One of the unique features of RCC is the tumor thrombus formation that migrates into the venous system including renal vein (RV) and inferior vena cava (IVC). Only 10 % of patients with RCC present with the classic triad of flank pain, hematuria and defined mass, while 25-30 % of affected patients are asymptomatic. Read More

    Hyperthyroidism-associated hypercalcemic crisis: A case report and review of the literature.
    Medicine (Baltimore) 2017 Jan;96(4):e6017
    Department of Endocrinology, Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
    Rationale: Hyperthyroidism is one of the major clinical causes of hypercalcaemia, however, hyperthyroidism-related hypercalcemic crisis is rare, only 1 case have been reported. The potential mechanisms are still not too clear. It may be related that thyroid hormone stimulate bone turnover, elevate serum calcium, increase urinary and fecal calcium excretion. Read More

    Endothelin-1 mediates natriuresis but not polyuria during vitamin D-induced acute hypercalcemia.
    J Physiol 2017 Jan 24. Epub 2017 Jan 24.
    Sorbonne Université, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138 team 3, Centre de Recherche des Cordeliers, CNRS ERL 8228, F-75006, Paris, France.
    Acute hypercalcemia increases urinary sodium and water excretion; however, the underlying molecular mechanism remains unclear. As vitamin D-induced hypercalcemia increases the renal expression of endothelin (ET)-1, we hypothesized that ET-1 mediates the effects of hypercalcemia on renal sodium and water handling. Hypercalcemia was induced in 8 week-old, PTH-supplemented, male mice by oral administration of dihydrotachysterol (DHT) for 3 days. Read More

    Hypercalcemia due to Primary Hepatic Lymphoma.
    Case Rep Hematol 2016 25;2016:1876901. Epub 2016 Dec 25.
    Department of Hematology and Oncology, University of Massachusetts Medical School, Worcester, MA, USA.
    A 65-year-old female with a history of mixed connective tissue disease and pulmonary fibrosis on azathioprine, hydroxychloroquine, and prednisone (osteoporosis on teriparatide) presented with a 1-month history of hypercalcemia. After discontinuation of teriparatide, the patient's hypercalcemia persisted. Further evaluation revealed primary hepatic lymphoma as the source of her hypercalcemia. Read More

    Calcium pyrophosphate deposition disease revealing a hypersensitivity to vitamin D.
    Joint Bone Spine 2017 Jan 18. Epub 2017 Jan 18.
    Department of Rheumatology, CHU de Caen, avenue Cote de Nacre, 14000 Caen, France; Normandy University, 14032 Caen cedex 5, France; UNICAEN, COMETE, 14032 Caen, France; Inserm, U 1075 COMETE, 14032 Caen, France.
    Objective: Hypersensitivity to vitamin D (HVD) due to a loss of function mutation of the CYP24A1 gene, which encodes vitamin D catabolizing enzyme was initially described as a cause of acute hypercalcemia in children and chronic renal diseases in adults.

    Methods: We describe the first case of a patient presenting a calcium pyrophosphate deposition disease (CPDD) revealing a HVD.

    Results: An abnormality of phospho-calcic metabolism was discovered during the course of an etiological workup for CPDD in a 52-year-old patient. Read More

    Predictors of operative failure in parathyroidectomy for primary hyperparathyroidism.
    Am J Surg 2017 Jan 10. Epub 2017 Jan 10.
    Department of Surgery, University of Michigan Medical School, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA. Electronic address:
    Introduction: Many adjuncts guide surgical decision making in parathyroidectomy, yet their independent associations with outcome are poorly characterized. We examined a broad range of perioperative factors and used multivariate techniques to identify independent predictors of operative failure (persistent disease) after parathyroidectomy.

    Methods: This was a retrospective review of 2239 patients with primary hyperparathyroidism who underwent parathyroidectomy at a single-center from 1999 to 2014. Read More

    Enlarged parathyroid glands with variable sonomorphology in a case of tertiary hyperparathyroidism: Sonographic-histopathologic correlation.
    Indian J Radiol Imaging 2016 Oct-Dec;26(4):513-516
    Department of Radiology, TNMC and BYL Nair Hospital, Mumbai, Maharashtra, India.
    The typical sonomorphology of homogeneously hypoechoic texture of an enlarged parathyroid gland (PG) is a reflection of uniform arrangement of the parathormone-producing chief cells. A variable cellular arrangement, hemorrhage, fibrosis, and adipocytes cause heterogeneous appearance. We describe a case of a 32-year-old male, a case of tertiary hyperparathyroidism, with increased serum parathormone levels, hypercalcemia, and enlargement of all four PGs, albeit with differing morphology. Read More

    Denosumab for the treatment of bisphosphonate resistant hypercalcemia in a hemodialysis patient.
    Saudi J Kidney Dis Transpl 2017 Jan-Feb;28(1):154-157
    Department of Nephrology and Dialysis, Hospital Louis Jaillon, Saint-Claude, France.
    The acronym of malignancy, iatrogenic, intoxication and immobilization, sarcoidosis, hyperparathyroidism and hyperthyroidism, milk-alkali syndrome, and paget is very helpful in diagnosing hypercalcemia. We report on a 94-year-old patient with history of end-stage renal failure secondary to benign nephroangiosclerosis, who was on maintenance hemodialysis during dialysis, his blood chemistry revealed mild hypercalcemia (2.66 mmol/L) with normal level of intact primary hyperparathyroidism (32. Read More

    A novel SLC12A1 gene mutation associated with hyperparathyroidism, hypercalcemia, nephrogenic diabetes insipidus, and nephrocalcinosis in four patients.
    Bone 2017 Jan 14;97:121-125. Epub 2017 Jan 14.
    Center for Endocrinology, Diabetes and Metabolism, Division of Endocrinology, Children's Hospital Los Angeles, Los Angeles, CA, United States; Keck School of Medicine of University of Southern California, Los Angeles, CA, United States. Electronic address:
    Solute Carrier Family 12 member 1 (SLC12A1) gene encodes the sodium-potassium-chloride co-transporter (NKCC2) at the apical membrane of the thick ascending loop of Henle (TAL). Bartter's syndrome (BS) type I is a rare, autosomal recessive, renal tubular disorder associated with mutation of the SLC12A1 gene. Presenting features include: hypokalemic metabolic alkalosis, hypercalciuria and nephrocalcinosis. Read More

    CYP24A1 loss of function: Clinical phenotype of monoallelic and biallelic mutations.
    J Steroid Biochem Mol Biol 2017 Jan 16. Epub 2017 Jan 16.
    Yale University, School of Medicine, New Haven, CT 06520-8064, United States. Electronic address:
    CYP24A1, encoding the vitamin D-24-hydroxylase, is of major clinical and physiologic importance, serving to regulate the catabolism of 1,25-(OH)2D, the physiologically active vitamin D metabolite. In addition to facilitating catabolism of 1,25-(OH)2D, CYP24A1 also enhances the turnover and elimination of 25-OHD, the abundant precursor metabolite and storage form of the vitamin. CYP24A1 can be stimulated hormonally by 1,25-(OH)2D and by FGF23, whereas CYP27B1, encoding the vitamin D-1α-hydroxylase, is stimulated hormonally by parathyroid hormone (PTH) and downregulated by FGF23. Read More

    Calcitriol-mediated Reversible Hypercalcemia in a Patient with Primary Adrenal Lymphoma.
    Malays J Med Sci 2016 Nov 7;23(6):118-122. Epub 2016 Dec 7.
    Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, 190006, India.
    Primary adrenal lymphomas (PAL) are rare occurrences with only less than 150 cases reported in the literature. Two-thirds of these cases were reported in the last decade due to the advancements in imaging techniques and immunohistochemistry. The non-specific signs and symptoms have resulted in a delayed onset of symptoms and diagnosis of these tumors. Read More

    [Clinical characteristics and prognosis in 12 patients with adult T cell leukemia/lymphoma confirmed by HTLV-1 provirus gene detection].
    Zhonghua Xue Ye Xue Za Zhi 2016 Dec;37(12):1027-1032
    Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
    Objective: To analyze the clinical characteristics and prognosis of adult T cell leukemia/lymphoma (ATLL). Methods: Peripheral blood samples from patients who were suspected as ATLL from March, 2013 to July, 2015, were collected for HTLV-1 provirus genes detection in genomic DNA extraction by PCR. Cases showing positive results were confirmed as ATLL. Read More

    A double-blind, randomized, placebo-controlled trial of combined calcitriol and ergocalciferol versus ergocalciferol alone in chronic kidney disease with proteinuria.
    BMC Nephrol 2017 Jan 14;18(1):19. Epub 2017 Jan 14.
    Division of Nephrology, Department of Medicine, King Chulalongkorn Memorial Hospital, Faculty of Medicine, Chulalongkorn University, 1873, Rama 4 Rd., Pathumwan, Bangkok, 10330, Thailand.
    Background: KDOQI guideline suggests that nutritional vitamin D should be supplemented in chronic kidney disease (CKD) patients who have vitamin D insufficiency/deficiency. However, there are scarce data regarding the additional benefit of active vitamin D supplement in CKD patients who were receiving nutritional vitamin D supplement. This study was conducted to explore the effect of adding active vitamin D to nutritional vitamin D supplement on proteinuria and kidney function in CKD with vitamin D insufficiency/deficiency. Read More

    Seven cases with Williams-Beuren syndrome: endocrine evaluation and long-term follow-up.
    J Pediatr Endocrinol Metab 2017 Feb;30(2):159-165
    Background: Endocrine evaluation and long-term follow-up of seven (six male) patients with Williams-Beuren syndrome (WBS) are given.

    Method: Data were obtained from patients' medical records. All patients underwent hormonal analyses and four of them underwent oral glucose tolerance test (OGTT). Read More

    Hypophosphatasia: Enzyme Replacement Therapy Brings New Opportunities and New Challenges.
    J Bone Miner Res 2017 Jan 13. Epub 2017 Jan 13.
    Department of Internal Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, and Center for Metabolic Bone Disease and Molecular Research, Shriners Hospital for Children, St. Louis, MO, USA.
    Hypophosphatasia (HPP) is caused by loss-of-function mutation(s) of the gene that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). Autosomal inheritance (dominant or recessive) from among more than 300 predominantly missense defects of TNSALP (ALPL) explains HPP's broad-ranging severity, the greatest of all skeletal diseases. In health, TNSALP is linked to cell surfaces and richly expressed in the skeleton and developing teeth. Read More

    Peptide vaccination against multiple myeloma using peptides derived from anti-apoptotic proteins: a phase I trial.
    Stem Cell Investig 2016 23;3:95. Epub 2016 Dec 23.
    Department of Hematology, Herlev and Gentofte Hospital, Herlev, Denmark.
    The B-cell lymphoma-2 (Bcl-2) family of proteins play a crucial role in multiple myeloma (MM), contributing to lacking apoptosis which is a hallmark of the disease. This makes the Bcl-2 proteins interesting targets for therapeutic peptide vaccination. We report a phase I trial of therapeutic vaccination with peptides from the proteins Bcl-2, Bcl-XL and Mcl-1 in patients with relapsed MM. Read More

    Can Stoss Therapy Be Used in Children with Vitamin D Deficiency or Insufficiency without Rickets?
    J Clin Res Pediatr Endocrinol 2017 Jan 12. Epub 2017 Jan 12.
    Objective: Stoss treatment has also been suggested due to non-skeletal benefits of vitamin D in adults, but no sufficient data are present about the optimal dose of vitamin D replacement in children with vitamin D deficiency/insufficiency without rickets. This study aimed to compare efficiency/side effects of two different stoss therapy regimens (10.000 IU/kg and 300. Read More

    Tissue-Engineered Model of Human Osteolytic Bone Tumor.
    Tissue Eng Part C Methods 2017 Feb;23(2):98-107
    1 Department of Biomedical Engineering, Columbia University , New York, New York.
    Ewing's sarcoma (ES) is a poorly differentiated pediatric tumor of aggressive behavior characterized by propensity to metastasize to bone. Interactions between the tumor and bone cells orchestrate a vicious cycle in which tumor cells induce osteoclast differentiation and activation to cause osteolytic lesions, broken bones, pain, and hypercalcemia. The lack of controllable models that can recapitulate osteolysis in ES impedes the development of new therapies and limits our understanding of how tumor cells invade bone. Read More

    MAJOR MOLECULAR GENETIC DRIVERS IN SPORADIC PRIMARY HYPERPARATHYROIDISM.
    Trans Am Clin Climatol Assoc 2016 ;127:235-244
    FARMINGTON, CONNECTICUT.
    Primary hyperparathyroidism is primarily due to a solitary parathyroid adenoma but multi-gland disease, parathyroid carcinoma, and ectopic parathyroid hormone production can occur. Although primary hyperparathyroidism mostly presents sporadically, strong familial predispositions also exist. Much is known about heritable genetic mutations responsible for these syndromes, including multiple endocrine neoplasia types 1 and 2A, hyperparathyroidism-jaw tumor syndrome, and familial hypocalciuric hypercalcemia. Read More

    Relationship between Urinary Calcium and Bone Mineral Density in Patients with Calcium Nephrolithiasis.
    J Urol 2017 Jan 4. Epub 2017 Jan 4.
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research; Department of Internal Medicine, Division of Nephrology; Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX.
    Background: Calcium nephrolithiasis is associated with an increased risk of osteoporosis and fracture. Hypercalciuria has been assumed to be pathogenic for bone loss in kidney stone formers (KSF), although this association was shown in small cross-sectional studies. We explored the association of urine calcium (UCaV) with bone mineral density (BMD) in KSF. Read More

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