20,747 results match your criteria Milk-Alkali Syndrome


Prognostic role of TNF alpha, LT alpha, MDR1 and codon 72 Tp53 gene polymorphisms on multiple myeloma Egyptian patients.

Leuk Res 2022 Apr 29;117:106854. Epub 2022 Apr 29.

Histology and Cytology Department, Faculty of Science, Mansoura University, Mansoura, Egypt.

Multiple Myeloma (MM) is a type of hematologic malignancies that characterized by uncontrolled plasma cell proliferation. So, the diagnosis depends on the increased numbers of abnormal, immature, or atypical plasma cells in the bone marrow, and many patients present with laboratory abnormalities, such as anemia, hypercalcemia, renal disease, and high protein levels in blood and urine. We aim to analyze the association of some genetic polymorphisms and its effect on the overall survival (OS) among MM patients. Read More

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Primary Hyperparathyroidism From Ectopic Parathyroid Adenoma in a 12-Year-Old With Slipped Capital Femoral Epiphysis.

J Endocr Soc 2022 Jun 7;6(6):bvac071. Epub 2022 May 7.

Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.

Primary hyperparathyroidism has been reported in pediatric patients presenting with slipped capital femoral epiphysis (SCFE), but never in patients with ectopic parathyroid adenoma. A 12-year-old boy with obesity and autism spectrum disorder presented with a limp and was found to have bilateral SCFE. Calcium was elevated to 12. Read More

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Germline Mutations Related to Primary Hyperparathyroidism Identified by Next-Generation Sequencing.

Front Endocrinol (Lausanne) 2022 28;13:853171. Epub 2022 Apr 28.

Department of Internal Medicine, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, South Korea.

Primary hyperparathyroidism (PHPT) is characterized by overproduction of parathyroid hormone and subsequent hypercalcemia. Approximately 10% of PHPT cases are hereditary, and several genes, such as , , , and , are responsible for the familial forms of PHPT. However, other genetic mutations involved in the etiology of PHPT are largely unknown. Read More

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Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells.

J Am Soc Nephrol 2022 May 17. Epub 2022 May 17.

School of Biosciences, Cardiff University, Cardiff, United Kingdom

Background: Impaired mineral ion metabolism is a hallmark of CKD-metabolic bone disorder. It can lead to pathologic vascular calcification and is associated with an increased risk of cardiovascular mortality. Loss of calcium-sensing receptor (CaSR) expression in vascular smooth muscle cells exacerbates vascular calcification Conversely, vascular calcification can be reduced by calcimimetics, which function as allosteric activators of CaSR. Read More

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An Unusual Case of Sarcoidosis: Hypercalcemia and Normal Sized Lymph Nodes.

Am J Med 2022 May 13. Epub 2022 May 13.

Department of Medicine and Dentistry, Division of Pulmonary Medicine, University of Alberta, Edmonton, Canada. Electronic address:

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Hypercalcaemia and hyperparathyroidism in surgical practice.

Authors:
K Bateman R J Egan

Br J Surg 2022 May;109(6):481-482

Morriston Hospital, Swansea, UK.

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Safety and Efficacy of Pamidronate in Neonatal Hypercalcemia Caused by Subcutaneous Fat Necrosis: A Case Report.

Front Pediatr 2022 28;10:845424. Epub 2022 Apr 28.

Neonatal Intensive Care Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.

Subcutaneous fat necrosis of the newborn (SCFN) is a panniculitis that develops in fatty areas after fetal or perinatal distress. Prognosis is generally good with complete regression, but it can be complicated by metabolic abnormalities like hypoglycemia, hypertriglyceridemia, thrombocytopenia, and also potentially life-threatening hypercalcemia. Treatments have included hydration, furosemide and corticosteroids. Read More

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Immobilization-Induced Hypercalcemia in COVID-19 With a Prolonged Intensive Care Unit Stay.

Cureus 2022 Apr 12;14(4):e24081. Epub 2022 Apr 12.

Hematology and Oncology, Pikeville Medical Center, Pikeville, USA.

Immobilization is an uncommon etiology of hypercalcemia. It is usually seen in conditions associated with limited movements such as spinal cord injuries, vascular events, or following prolonged hospitalization. Hereby, we present a case of a young patient who had prolonged hospitalization following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Read More

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Seizures Associated With Bone Density Conservation Agents.

J Pharm Technol 2022 Apr 26;38(2):119-126. Epub 2022 Jan 26.

Bon Secours Mercy Health St. Vincent Medical Center, Toledo, OH, USA.

Objective: The purpose of this review is to discuss the existing literature regarding patients who have experienced seizures after administration of a bone density conservation agent (BDCA).

Data Sources: A comprehensive literature review was performed between September and October 2021 using the following keywords: osteoporosis/drug therapy, seizures/chemically induced, hypercalcemia, hypocalcemia, osteoporosis, seizure risk, osteoclast medication, seizures, bisphosphonates, risedronate, zoledronic acid, pamidronate, denosumab, Prolia, Xgeva, calcitonin, BDCAs.

Study Selection And Data Extraction: A total of 90 articles were identified, but only 6 articles met prespecified inclusion and exclusion criteria. Read More

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Long-term efficacy and safety of rifampin in the treatment of a patient carrying a CYP24A1 loss-of-function variant.

J Clin Endocrinol Metab 2022 May 15. Epub 2022 May 15.

University Hospital of Pisa, Endocrine Unit, Pisa, Italy.

Background: Pharmacological therapy may be useful in the treatment of moderate to severe hypercalcemia in patients with infantile hypercalcemia-1 (HCINF1) due to pathogenic variants in the cytochrome P450 24 subfamily A member 1 (CYP24A1). Rifampin is an antituberculosis drug that is a potent inducer of cytochrome P450 3 subfamily A member 4 (CYP3A4), involved in an alternative catabolic pathway of vitamin D. The efficacy of rifampin in improving hypercalcemia was previously reported but many questions remain on the long-term efficacy and safety. Read More

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Disorders of the Calcium Sensing Signaling Pathway: From Familial Hypocalciuric Hypercalcemia (FHH) to Life Threatening Conditions in Infancy.

J Clin Med 2022 May 5;11(9). Epub 2022 May 5.

Department of Pediatrics, St. Josef-Hospital Bochum, Ruhr-University Bochum, 44791 Bochum, Germany.

Familial hypocalciuric hypercalcemia (FHH) is a mostly benign condition of elevated calcium and PTH levels based on a hyposensitive calcium sensing receptor () in FHH 1 or its downstream regulatory pathway in FHH2 and FHH3. In children, adolescents and young adults with FHH the main challenge is to distinguish the condition from primary hyperparathyroidism and thereby to avoid unnecessary treatments including parathyroidectomy. However, inheritance of FHH may result in neonatal hyperparathyroidism (NHPT) or neonatal severe hyperparathyroidism (NSHPT), conditions with high morbidity, and in the latter even high mortality. Read More

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Multiple Myeloma: 2022 update on Diagnosis, Risk-stratification and Management.

Am J Hematol 2022 May 12. Epub 2022 May 12.

From the Division of Hematology, Mayo Clinic, Rochester, Minnesota.

Disease Overview: Multiple myeloma accounts for approximately 10% of hematologic malignancies.

Diagnosis: The diagnosis requires ≥10% clonal bone marrow plasma cells or a biopsy proven plasmacytoma plus evidence of one or more multiple myeloma defining events (MDE): CRAB (hypercalcemia, renal failure, anemia, or lytic bone lesions) attributable to the plasma cell disorder, bone marrow clonal plasmacytosis ≥60%, serum involved/uninvolved free light chain (FLC) ratio ≥100 (provided involved FLC is ≥100 mg/L), or >1 focal lesion on magnetic resonance imaging.

Risk Stratification: The presence of del(17p), t(4;14), t(14;16), t(14;20), gain 1q, or p53 mutation is considered high-risk multiple myeloma. Read More

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Investigation of the Antiangiogenic Properties of Zoledronic Acid by Using Chorioallantoic Membrane Model.

Dose Response 2022 Apr-Jun;20(2):15593258221093410. Epub 2022 Apr 27.

Department of Orthopedics and Traumatology, Medical School of Alaaddin Keykubat University, Alanya, Turkey.

Objective: Zoledronic acid (ZA) is a bisphosphonate-derived agent used in osteoporotic clinical pathologies to prevent the development of complications such as fractures and hypercalcemia by regulating bone metabolism. Studies have been conducted on the antiangiogenic efficacy of this agent, which also has other systemic side effects. In this study, the dose-dependent antiangiogenic activity of ZA was investigated on the chorioallantoic membrane model (CAM). Read More

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Dent-2 disease with a Bartter-like phenotype caused by the Asp631Glu mutation in the OCRL gene.

BMC Nephrol 2022 May 12;23(1):182. Epub 2022 May 12.

Nephrology Department, Heraklion University Hospital, Voutes, 71500, Heraklion, Crete, Greece.

Background: Dent disease is an X-linked disorder characterized by low molecular weight proteinuria (LMWP), hypercalciuria, nephrolithiasis and chronic kidney disease (CKD). It is caused by mutations in the chloride voltage-gated channel 5 (CLCN5) gene (Dent disease-1), or in the OCRL gene (Dent disease-2). It is associated with chronic metabolic acidosis; however metabolic alkalosis has rarely been reported. Read More

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Synchronous Parathyroid Carcinoma and Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features.

Cureus 2022 Apr 10;14(4):e24006. Epub 2022 Apr 10.

Department of General Surgery, Salmaniya Medical Complex, Manama, BHR.

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. Compared to parathyroid adenoma, parathyroid cancer is more likely to be associated with marked levels of serum parathyroid hormone (PTH) and hypercalcemia with severe clinical manifestations. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a rare variant of papillary thyroid cancer. Read More

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Diagnosis and treatment of multiple myeloma in Hunan Province.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr;47(4):497-504

Department of Hematology, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Objectives: There is less clinical data on multiple myeloma (MM) in China, and the aim of this study was to collect and analyze the clinical data of newly diagnosed multiple myeloma (NDMM) patients in Hunan Province during 1 year, to understand the real clinical features and treatment outcome for Hunan Province patients with MM, and to strengthen the understanding of the standardized diagnosis process and treatment plan of MM.

Methods: The clinical data of 529 patients with NDMM in 12 large-scale general hospitals in Hunan Province from January 1 to December 31, 2019 were collected and analyzed, including baseline data, treatment regimens, duration of treatment, and adverse reactions. The clinical characteristics, treatment, and safety of patients were analyzed by SPSS 21. Read More

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Parathyroid hormone-independent hypercalcaemia secondary to granulomatous inflammation: could this be melioidosis?

Intern Med J 2022 May;52(5):893-894

Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.

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Ectopic parathyroid hormone as a rare aetiology of hypercalcemia with rhabdomyosarcoma: a new treatment strategy with Zoledronic Acid and Denosumab.

J Pediatr Endocrinol Metab 2022 May 10. Epub 2022 May 10.

Division of Pediatric Endocrinology, Department of Pediatrics, School of Medicine, Kocaeli University, İzmit, Kocaeli, Turkey.

Objectives: Ectopic parathyroid hormone (PTH) secretion is rare in children with rhabdomyosarcoma, and only a few pediatric cases have been reported to date. Reports of the use of Zoledronic Acid (ZA) and Denosumab are limited for the treatment of hypercalcemia of malignancy (HCM) in the pediatric population. The aim of presenting this pediatric case of rhabdomyosarcoma accompanied by HCM, secondary to ectopic PTH secretion, was to highlight the benefits of ZA as a first-choice bisphosphonate in this situation with Denosumab as an alternative therapy. Read More

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Severe Hypercalcemia From Inhalation Pneumonitis via Activation of 1,25 Dihydroxyvitamin D.

J Endocr Soc 2022 Jun 22;6(6):bvac066. Epub 2022 Apr 22.

Department of Internal Medicine, Division of Endocrinology, and the Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, Kentucky 40536, USA.

Among the many causes of hypercalcemia are inflammatory conditions, particularly involving granulomatous disease. We present a case of a previously healthy woman who arrived at the emergency department with severe symptomatic hypercalcemia. Workup revealed elevated levels of 1,25-dihydroxyvitamin D along with pneumonitis on computed tomography (CT) imaging. Read More

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Novel methods of predicting ionized calcium status from routine data in critical care: External validation in MIMIC-III.

Clin Chim Acta 2022 May 5;531:375-381. Epub 2022 May 5.

Department of Medicine, Veterans Affairs New York Harbor Healthcare System, 800 Poly Place, Brooklyn, NY, USA.

Background: Low ionized calcium (I) is prevalent and prognostic in critical care, but poorly detected by either total calcium (T) or albumin-corrected T (cT). We recently derived models of I (Pred-I) and low I (Prob) in critical care that adjust T for binding to albumin and small anions-represented by the anion gap's components. On internal validation, they outperformed cT in diagnosing low I. Read More

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Successful Treatment of Ureteral Obstructive Lithiasis by Ureterotomy in a Domestic Hen.

J Avian Med Surg 2022 May;36(1):70-77

Division of Diagnostic Imaging, Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands.

A 2-year-old domestic hen was presented for a 15-day history of intermittent left leg lameness. The owners also observed a decrease in egg quality during that period. Physical examination of the bird revealed a generalized weakness with a flattened pale comb. Read More

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Metabolic Alkalosis Pathogenesis, Diagnosis, and Treatment: Core Curriculum 2022.

Am J Kidney Dis 2022 May 4. Epub 2022 May 4.

Division of Nephrology, Department of Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico. Electronic address:

Metabolic alkalosis is a widespread acid-base disturbance, especially in hospitalized patients. It is characterized by the primary elevation of serum bicarbonate and arterial pH, along with a compensatory increase in Pco consequent to adaptive hypoventilation. The pathogenesis of metabolic alkalosis involves either a loss of fixed acid or a net accumulation of bicarbonate within the extracellular fluid. Read More

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Vitamin D toxicity due to self-prescription: A case report.

J Family Med Prim Care 2022 Apr 18;11(4):1561-1563. Epub 2022 Mar 18.

Department Clinical Hematology, SKIMS, Srinagar, Jammu and Kashmir, India.

Apart from maintaining healthy bones, vitamin D is also required for cell differentiation, cell growth inhibition, and immune modulation. Vitamin D deficiency is common in the Indian subcontinent. Vitamin D presenting toxicity, leading to hypercalcemia, acute kidney injury, and altered sensorium is very rare. Read More

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Glucocorticoid-induced adrenal insufficiency: an uncommon cause of hypercalcaemia.

Endocrinol Diabetes Metab Case Rep 2022 May 1;2022. Epub 2022 May 1.

University Medical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.

Summary: Long-term use of exogenous glucocorticoids leads to the suppression of the hypothalamic-pituitary-adrenal axis. Therefore, if the glucocorticoid is withdrawn abruptly, patients will develop adrenal insufficiency. Hypercalcaemia is a rare but well-known complication of adrenal insufficiency. Read More

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Severe Hypercalcemia as an Initial Presentation of Advanced Hepatocellular Carcinoma: A Case Report.

Cancer Manag Res 2022 28;14:1577-1580. Epub 2022 Apr 28.

Radiology Department, Mogadishu Somali Turkey, Recep Tayyip Erdogan, Training and Research Hospital, Mogadishu, Somalia.

Background: It is extremely rare for hypercalcemia to appear as the first symptom of hepatocellular carcinoma. Instead, it occurs primarily as a paraneoplastic manifestation after the disease is already diagnosed.

Methods: In this report, we describe a 55-year-old woman who presented with symptoms of acute severe hypercalcemia and was negative for hepatitis B surface antigen and hepatitis C virus antibodies. Read More

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The Importance of Functionally Characterizing Calcium-Sensing Receptor Variants in Individuals With Hypercalcemia.

J Endocr Soc 2022 Jun 4;6(6):bvac052. Epub 2022 Apr 4.

Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK.

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Hypercalcemia as the Initial Presentation of Acute T-cell Leukemia/Lymphoma.

Cureus 2022 Mar 31;14(3):e23705. Epub 2022 Mar 31.

Department of Dermatology, New York University, New York, USA.

Adult T-cell leukemia/lymphoma (ATLL) is a T-cell malignancy that generally presents with widespread involvement of lymph nodes, peripheral blood, and/or skin. It is an uncommon malignancy linked to the human T-lymphotropic virus 1 (HTLV-1). Herein, we present a case of ATLL that was diagnosed after a patient presented to our hospital with nonspecific symptoms of fatigue and weakness and was subsequently found to have hypercalcemia secondary to his blood malignancy. Read More

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Risk factors for surgical failure in patients undergoing surgery for primary hyperparathyroidism.

Cir Esp (Engl Ed) 2022 Apr 30. Epub 2022 Apr 30.

Servicio de Cirugía de Cabeza y Cuello, Hospital Privado Universitario de Córdoba, Córdoba, Argentina; Servicio de Cirugía de Cabeza y Cuello, Hospital Raúl Ferreyra, Córdoba, Argentina; Instituto Universitario de Ciencias Biomédicas de Córdoba, Córdoba, Argentina.

Introduction: Primary hyperparathyroidism is the third most common endocrine disease. The aim of our study was to determine long-term outcomes and risk factors for persistence in patients undergoing parathyroidectomy for primary hyperparathyroidism.

Methods: Retrospective study including patients undergoing parathyroidectomy between 2009-2019. Read More

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Letter Regarding "Granulomatous Inflammation and Hypercalcemia in Patients With Severe Systemic Oxalosis".

Kidney Int Rep 2022 Apr 12;7(4):930-931. Epub 2022 Feb 12.

Service of Nephrology and Hypertension, Lausanne University Hospital, Lausanne, Switzerland.

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