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    Hypercalcemia as a rare presentation of angioimmunoblastic T cell lymphoma: a case report.
    J Med Case Rep 2018 Apr 20;12(1):101. Epub 2018 Apr 20.
    Department of Internal Medicine, Wayne State University School of Medicine, Rochester Hills, MI, USA.
    Background: Angioimmunoblastic T cell lymphoma is a rare malignancy, accounting for only 2% of all non-Hodgkin lymphomas, first described in the 1970s and subsequently accepted as a distinct entity in the current World Health Organization classification. Due to the paucity of this disease, there is still no identifiable etiology, no consistent risk factors, and the pathogenesis remains unclear.

    Case Presentation: An 83-year-old Caucasian man presented to an emergency department with palpitations and was found to have atrial fibrillation. Read More

    The Use of Low-Calcium Hemodialysis in the Treatment of Hypercalcemic Crisis.
    Nephron 2018 Apr 19. Epub 2018 Apr 19.
    Department of Nephrology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey.
    Background: We reviewed the results of low-calcium hemodialysis (LCHD; 1.25 mmol/L) in the treatment of 42 cases admitting with hypercalcemic crisis.

    Methods: All patients (≥18 years) who started LCHD due to hypercalcemia between 2002 and 2017 were retrospectively analyzed. Read More

    Aggregation-Induced Emission Probe for Light-Up and in Situ Detection of Calcium Ions at High Concentration.
    ACS Appl Mater Interfaces 2018 Apr 19. Epub 2018 Apr 19.
    Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , The Hong Kong University of Science & Technology , Clear Water Bay, Kowloon , Hong Kong, China.
    The fluorescent probe for the detection of calcium ions is an indispensable tool in the biomedical field. The millimolar order of Ca(II) ions is associated with many physiological processes and diseases, such as hypercalcemia, soft tissue calcification, and bone microcracks. However, the conventional fluorescent probes are only suitable for imaging Ca(II) ions in the nanomolar to micromolar range, which can be because of their high affinities toward Ca(II) ions and aggregation-caused quenching drawbacks. Read More

    Synthetic biology-based cellular biomedical tattoo for detection of hypercalcemia associated with cancer.
    Sci Transl Med 2018 Apr;10(437)
    Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.
    Diagnosis marks the beginning of any successful therapy. Because many medical conditions progress asymptomatically over extended periods of time, their timely diagnosis remains difficult, and this adversely affects patient prognosis. Focusing on hypercalcemia associated with cancer, we aimed to develop a synthetic biology-inspired biomedical tattoo using engineered cells that would (i) monitor long-term blood calcium concentration, (ii) detect onset of mild hypercalcemia, and (iii) respond via subcutaneous accumulation of the black pigment melanin to form a visible tattoo. Read More

    Response to Long-term Vitamin D Therapy for Bone Disease in Children With Sickle Cell Disease.
    J Pediatr Hematol Oncol 2018 Apr 17. Epub 2018 Apr 17.
    Division of Pediatric Endocrinology, Columbia University Medical Center.
    Patients with sickle cell disease (SCD) are at risk for bone fragility from multiple factors including vitamin D deficiency. To date, no studies have evaluated the efficacy and safety of long-term vitamin D therapy for bone disease in children with SCD. We report a cohort of 4 children with SCD found to have severe vitamin D deficiency, secondary hyperparathyroidism, and abnormal bone mineral density treated with monthly high-dose oral cholecalciferol over 2 years. Read More

    [Hypophosphatemia in preterm infants: a bimodal disorder].
    Rev Chil Pediatr 2018 Feb;89(1):10-17
    Complejo Asistencial Dr. Sótero del Río, Santiago, Chile.
    New nutritional approaches to treat extreme premature babies have demonstrated relevant eviden ce of metabolic disturbances with early hypophosphatemia, especially in patients with intrauterine growth restriction (IUGR). They have shown late hypophosphatemia, as well, which is characteristic in the metabolic bone disease. A sytematic search of literature describing metabolic disturbances of phosphorus in preterm newborns is presented, related to the use of early parenteral nutrition and also in the context of metabolic bone disease. Read More

    Decrement in bone mineral density after parathyroidectomy in a pediatric patient with primary hyperparathyroidism.
    Clin Pediatr Endocrinol 2018 13;27(2):81-86. Epub 2018 Apr 13.
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Primary hyperparathyroidism (PHT) causes increased bone turnover, leading to reduction in bone mineral density (BMD). Parathyroidectomy is a definitive therapy and improves BMD in adult patients with PHT. However, there are no reports regarding alterations of BMD in pediatric or adolescent patients with PHT. Read More

    Calcitonin Stewardship Strategies.
    J Pharm Pract 2018 Jan 1:897190018770052. Epub 2018 Jan 1.
    2 Inpatient Operations Supervisor, University of Florida Health Jacksonville, Jacksonville, FL, USA.
    Despite being approved by the Food and Drug Administration for over 30 years, calcitonin salmon has seen a dramatic increase in acquisition cost over the last few years. Being commonly used for the treatment of hypercalcemia of malignancy, health systems must implement stewardship strategies in order to curtail usage. This review is intended to provide a background on calcitonin usage for hypercalcemia of malignancy and associated strategies to ensure appropriateness of utilization within health systems. Read More

    Identification of Differential Transcriptional Patterns in Primary and Secondary Hyperparathyroidism.
    J Clin Endocrinol Metab 2018 Apr 5. Epub 2018 Apr 5.
    Division of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospitals of Geneva, Switzerland.
    Context: Hyperparathyroidism is associated with hypercalcemia and the excess of parathyroid hormone secretion. However, the alterations in molecular pattern of functional genes during parathyroid tumorigenesis have not been unraveled. We aimed at establishing transcriptional patterns of normal and pathological parathyroid glands (PG) in sporadic primary and secondary hyperparathyroidism (HPT1, 2). Read More

    Hypercalcemic crisis in third trimenon: evaluating the optimal treatment strategy.
    Gynecol Endocrinol 2018 Apr 16:1-4. Epub 2018 Apr 16.
    a Division of Endocrinology, Diabetes and Metabolism , University Hospital Basel , Switzerland.
    Hypercalcemia due to primary hyperparathyroidism during pregnancy is a rare condition and associated with increased morbidity and mortality for the mother and the unborn child. Whereas parathyroidectomy is favored during the second trimester, no clear recommendations exist for its management during the third trimenon. We here report the case of a 26-year-old woman in the 29th week of her first pregnancy, who was admitted to our clinic with hypertension, intra-uterine growth retardation and polyhydramnios. Read More

    Primary hyperparathyroidism and Gougerot disease.
    Eur J Rheumatol 2018 Mar 2;5(1):72-74. Epub 2017 Nov 2.
    Department of Endocrinology, Diabetology and Nutrition, University Hospital Hassan II, Fez, Morocco.
    Primary hyperparathyroidism (PHPT) is a common endocrine disorder caused by the overactivation of the parathyroid glands due to the autonomous production of the parathyroid hormone (PTH). The resultant hypercalcemia leads to a myriad of symptoms. Here we report the case of a 54-year-old female with a previous diagnosis of Gougerot disease, in whom clinical (diffuse bone pain, asthenia polydipsia, and polyuria) and laboratory features (calcium level, 3. Read More

    Hypercalcemia in a bodybuilder with cosmetic silicone injections.
    N Z Med J 2018 Apr 13;131(1473):78-81. Epub 2018 Apr 13.
    Nephrology and Hypertension, Department of Nephrology and Hypertension, Al-Zahraa University Hospital, Beirut, Lebanon.
    Granulomatous hypercalcemia due to silicone injections is a rare disease with scarce literature. We present a case of a 35-year-old Caucasian male bodybuilder with multiple silicone injections in his upper extremities who developed hypercalcemia and urinary symptoms. He necessitated two sessions of dialysis. Read More

    The use of PET/CT in pregnancy: A case report of malignant parathyroid carcinoma and a review of the literature.
    Obstet Med 2018 Mar 9;11(1):45-49. Epub 2017 Oct 9.
    1Department of Medicine, University of Alberta, Edmonton, Canada.
    Positron emission tomography scanning is not commonly performed in pregnancy but can be done if required. Fetal doses of radiation can be minimized, and our case exemplifies the safe application of positron emission tomography/computed tomography in pregnancy. A 38-year-old woman in her first ongoing pregnancy presented at 28 weeks' gestation with symptomatic hypercalcemia. Read More

    Cutaneous complication of perinatal hypoxia.
    Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
    Dermatology Department, Hospital de Santarém EPE, Santarém, Portugal.
    Subcutaneous fat necrosis of the newborn is an uncommon, transient, and self-healing panniculitis, mostly affecting term newborns with perinatal complications. The authors present a case of a female full-term neonate, born from an uncomplicated pregnancy, admitted into the neonatology unit 5 hours after delivery because of refractory multifocal seizures in the context of hypoxic-ischemic encephalopathy. Nine days after birth, indurated and erythematous nodules and plaques were noted on the left arm and back. Read More

    A Rare Case of Calciphylaxis in an Orthotopic Liver Transplant Recipient with Acute Kidney Injury.
    Exp Clin Transplant 2018 Apr 9. Epub 2018 Apr 9.
    From the Department of Transplant Nephrology, Einstein Medical Center, Philadelphia, Pennsylvania, USA.
    Calciphylaxis is a rare disease characterized by calcification of small- to medium-sized blood vessels in the dermis and subcutaneous fat, resulting in cutaneous necrosis. Although most commonly shown in patients with end-stage kidney disease, it has also been reported in patients with other diseases, including alcoholic cirrhosis and malignancies. Here, we report an unusual case of calciphylaxis in an orthotopic liver transplant recipient with acute kidney injury. Read More

    Hypercalcemia and acute pancreatitis in a male patient with acute promyelocytic leukemia and pulmonary tuberculosis.
    Acta Biomed 2018 Apr 3;89(3-S):23-27. Epub 2018 Apr 3.
    Hematologists, Department of Hematology, NCCCR, Hamad Medical Corporation (HMC), Doha, Qatar.
    We report a rare case of hypercalcemia and acute pancreatitis in a subject with acute promyelocytic leukemia (APL) and pulmonary tuberculosis, during all-trans-retinoic acid (ATRA) treatment. Both associated complications were potentially due to several causes. A careful monitoring and exclusion of all causative factors must be addressed. Read More

    Soluble Klotho causes hypomineralization in Klotho-deficient mice.
    J Endocrinol 2018 Apr 9. Epub 2018 Apr 9.
    Y Yoshiko, Oral Grwoth and Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, 734-8553, Japan
    The type I transmembrane protein αKlotho (Klotho) serves as a coreceptor for the phosphaturic hormone fibroblast growth factor 23 (FGF23) in kidney, while a truncated form of Klotho (soluble Klotho, sKL) is thought to exhibit multiple activities, including acting as a hormone, but whose mode(s) of action in different organ systems remains to be fully elucidated. FGF23 is expressed primarily in osteoblasts/osteocytes and aberrantly high levels in the circulation acting via signaling through an FGF receptor (FGFR)-Klotho coreceptor complex cause renal phosphate wasting and osteomalacia. We assessed the effects of exogenously added sKL on osteoblasts and bone using Klotho-deficient () mice and cell and organ cultures. Read More

    Management of hypercalcaemic crisis in adults: Current role of renal replacement therapy.
    Am J Emerg Med 2018 Mar 7. Epub 2018 Mar 7.
    Nephrology unit, University Hospital Mohammed VI, University Mohammed the First, Oujda, Morocco.
    Neoplasms and hematologic diseases are the predominant etiologies of hypercalcemic crisis in adults and the immediate treatment is mainly medical and symptomatic. The use of renal replacement therapy (RRT) is often necessary to correct the hypercalcemia, uremia and electrolyte disturbances related to Acute Kidney Injury (AKI). The aim of this work was to determine the etiologies and the place of RRT in treating patients with hypercalcaemic crisis. Read More

    Effect of Lanthanum Carbonate on All-Cause Mortality in Patients Receiving Maintenance Hemodialysis: a Meta-Analysis of Randomized Controlled Trials.
    Kidney Blood Press Res 2018 Mar 29;43(2):536-544. Epub 2018 Mar 29.
    Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
    Background/aims: Hyperphosphatemia is common in patients on hemodialysis. The efficacy of lanthanum carbonate (LC) in the treatment of hyperphosphatemia in these patients remains controversial. The objective of this meta-analysis was to evaluate the effect of LC on all-cause mortality in patients on maintenance hemodialysis. Read More

    Osteoblast-secreted WISP-1 promotes adherence of prostate cancer cells to bone via the VCAM-1/integrin α4β1 system.
    Cancer Lett 2018 Apr 6;426:47-56. Epub 2018 Apr 6.
    School of Medicine, China Medical University, Taichung, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung, Taiwan; Department of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan. Electronic address:
    Bone metastasis is a frequent occurrence in prostate cancer (PCa) that is associated with severe complications such as fracture, bone pain and hypercalcemia. The cross-talk between metastatic cancer cells and bone is critical to the development and progression of bone metastases. In our previous data, we have described how the involvement of the Wnt-induced secreted protein-1/vascular cell adhesion molecule-1 (WISP-1/VCAM-1) system in this tumor-bone interaction contributes to human PCa cell motility. Read More

    A rare case of hypercalcemia-induced pancreatitis in a first trimester pregnant woman.
    Endocrinol Diabetes Metab Case Rep 2018 28;2018. Epub 2018 Mar 28.
    Rafic Hariri University Hospital, Beirut, Lebanon.
    The objective of the study is to report a case of acute pancreatitis secondary to hypercalcemia induced by primary hyperparathyroidism in a pregnant woman at the end of the first trimester. The case included a 32-year-old woman who was diagnosed with acute pancreatitis and severe hypercalcemia refractory to many regimens of medical therapy in the first trimester of pregnancy. She was successfully treated with parathyroidectomy in the early second trimester with complete resolution of hypercalcemia and pancreatitis. Read More

    Esophageal Mucosal Calcinosis: A Rare Site of Gastrointestinal Mucosal Calcinosis.
    Am J Case Rep 2018 Apr 6;19:406-409. Epub 2018 Apr 6.
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
    BACKGROUND Gastrointestinal tract mucosal calcinosis (MC) tends to affect the gastric mucosa, while esophageal involvement is rare. Gastric MC may be seen with solid organ transplantation, use of aluminum-containing antacids or sucralfate, malignancy, and chronic renal failure. While the incidence of gastric MC in renal transplant patients undergoing gastric biopsy is common (between 15-29%), to our knowledge esophageal MC has only been previously reported 3 times. Read More

    Usefulness of pretransplant aortic arch calcification evaluation for kidney transplant outcome prediction in one year follow-up.
    Ren Fail 2018 Nov;40(1):201-208
    a Clinic of Gastroneterology, Nephrourology and Abdominal Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University , Vilnius , Lithuania.
    Vascular calcification (VC) is linked to post-transplant cardiovascular events and hypercalcemia which may influence kidney graft function in the long term. We aimed to evaluate whether pretransplant aortic arch calcification (AoAC) can predict post-transplant cardiovascular or cerebrovascular events (CVEs), and to assess its association with post-transplant plasma calcium levels and renal function in one-year follow-up. Our single-center observational prospective study enrolled 37 kidney transplant recipients (KTR) without previous history of vascular events. Read More

    A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro.
    PLoS One 2018 3;13(4):e0195316. Epub 2018 Apr 3.
    Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Kanagawa, Japan.
    Cinacalcet hydrochloride (cinacalcet), an oral calcimimetic agent has been widely used for the management of secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD). In sharp contrast to vitamin D receptor activators, cinacalcet suppresses SHPT without inducing hypercalcemia or hyperphosphatemia. Nevertheless, some patients remain refractory to SHPT with this agent, as the dose cannot be sufficiently increased due to gastrointestinal symptoms. Read More

    Blue Diaper Syndrome and Mutations.
    Pediatrics 2018 Apr;141(Suppl 5):S501-S505
    Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
    Blue diaper syndrome (BDS) (Online Mendelian Inheritance in Man number 211000) is an extremely rare disorder that was first described in 1964. The characteristic finding is a bluish discoloration of urine spots in the diapers of affected infants. Additional clinical features of the first described patients included diarrhea, inadequate weight gain, hypercalcemia, and nephrocalcinosis. Read More

    Preterm Parturient with Polyhydramnios and Pancreatitis: Primary Presentation of Hyperparathyroidism.
    Case Rep Obstet Gynecol 2018 21;2018:2091082. Epub 2018 Jan 21.
    Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Objective: To report a case of severe hypercalcemia secondary to primary hyperparathyroidism in a late-preterm pregnant patient and review medical and surgical treatments as well as obstetric and neonatal outcomes.

    Background: Diagnosis of parathyroid disease during pregnancy can be difficult due to nonspecific presentation. Management decisions are complex and require multidisciplinary collaboration. Read More

    [Disturbances of calcium metabolism and vitamin D supplementation in sarcoidosis - two-way street].
    Pol Merkur Lekarski 2018 Mar;44(261):147-149
    1st Department of Lung Diseases, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
    The role of vitamin D in the human body is not limited only to the regulation of calcium metabolism and secondary to the impact on bones. Recent studies have shown the influence of vitamin D level on muscles, on the risk of cancer, diabetes, hypertension and pulmonary diseases, including granulomatous diseases. Sarcoidosis is a granulomatous disease of unknown etiology. Read More

    [The diagnostic algorithm of practice in pulmonary and extrapulmonary sarcoidosis].
    Pol Merkur Lekarski 2018 Mar;44(261):101-109
    Department of Pulmonology, Medical University of Gdansk, Poland.
    Sarcoidosis (SA) is a granulomatous multisystem disease of unknown ethiology. Pulmonary, lymphadenopathy, liver, spleen, skin, and bone sarcoidosis are more frequent but also SA of the heart, central nervous system, eye, and hypercalcemia with following kidney failure also occur. Sarcoidosis may co-exist with extrapulmonary forms, which may overtake or precede each other. Read More

    Non-parathyroid hypercalcemia associated with paraffin oil injection in 12 younger male bodybuilders.
    Eur J Endocrinol 2018 Mar 29. Epub 2018 Mar 29.
    L Rejnmark, Depatment of endocrinology and internal medicine, Aarhus Universitetshospital, Aarhus, Denmark.
    Introduction: Injection of paraffin oil to augment muscles size is a troubling phenomenon known to cause a foreign-body reaction with formation of granulomas. In a few case-reports, long-term side effects have been reported in terms of hypercalcemia and renal failure.

    Methods: We identified a case series of 12 male bodybuilders presenting with non-parathyroid hypercalcemia who previously had injected paraffin oil to increase muscles size. Read More

    Long-term effects of low calcium dialysates on the serum calcium levels during maintenance hemodialysis treatments: A systematic review and meta-analysis.
    Sci Rep 2018 Mar 28;8(1):5310. Epub 2018 Mar 28.
    Department of iPS Cell Research & Epigenetic Medicine, Keio University School of Medicine, Tokyo, Japan.
    Hypercalcemia and hyperparathyroidism in patients receiving maintenance hemodialysis (MHD) can cause the progression of cardiovascular diseases (CVD) and mineral bone disorders (MBD). The KDIGO recommends the dialysates with a calcium (Ca) concentration of 1.25-1. Read More

    Effects of Serum Albumin, Calcium Levels, Cancer Stage and Performance Status on Weight Loss in Parathyroid Hormone-Related Peptide Positive or Negative Patients with Cancer.
    Endocrinol Metab (Seoul) 2018 Mar;33(1):97-104
    Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Background: A recent animal study showed that parathyroid hormone-related peptide (PTHrP) is associated with cancer cachexia by promoting adipose tissue browning, and we previously demonstrated that PTHrP predicts weight loss (WL) in patients with cancer. In this study, we investigated whether prediction of WL by PTHrP is influenced by clinical factors such as serum albumin, corrected calcium levels, cancer stage, and performance status (PS).

    Methods: A cohort of 219 patients with cancer whose PTHrP level was measured was enrolled and followed for body weight (BW) changes. Read More

    Localized hepatic tuberculosis presenting as severe hypercalcemia.
    Indian J Tuberc 2018 Apr 22;65(2):172-174. Epub 2017 Aug 22.
    Center for Diabetes and Endocrinology of the state of Pará, Jean Bitar Hospital, Belém, PA, Brazil.
    Hypercalcemia might present itself in association with granulomatous diseases such as tuberculosis. We report a rare case of a 62-year-old man with hypercalcemia due to hepatic tuberculosis. The diagnosis was based on laparoscopic and a histopathological examination. Read More

    A rapid screening of a recurrent CYP24A1 pathogenic variant opens the way to molecular testing for Idiopathic Infantile Hypercalcemia (IIH).
    Clin Chim Acta 2018 Mar 21;482:8-13. Epub 2018 Mar 21.
    Laboratory of Clinical Pathology and Advanced Molecular Diagnostics, Istituto Dermopatico dell'Immacolata -IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Roma, Italy. Electronic address:
    Introduction: Loss-of-function mutations in cytochrome P450 family 24 subfamily A member 1 (CYP24A1) gene are associated with Idiopathic Infantile Hypercalcemia (IIH) and adult kidney stone disease. The enzyme deficiency leads to an impaired vitamin D catabolism pathway, resulting in a syndrome characterized by recurrent hypercalcemia, hypercalciuria and suppressed parathyroid hormone (PTH) levels. In these patients, the genetic evaluation of CYP24A1 is an important diagnostic tool, allowing the definitive diagnosis of IIH. Read More

    Clinical value of 11C-methionine positron emission tomography in persistent primary hyperparathyroidism-A case report with a mediastinal parathyroid adenoma.
    Int J Surg Case Rep 2018 Mar 15;45:63-66. Epub 2018 Mar 15.
    Department of Otorhinolaryngology, Aarhus University Hospital, Denmark.
    Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder caused by pathologic growth of one or more of the parathyroid glands. Parathyroidectomies (PTX) in patients with PHPT are procedures with low morbidity, few complications, and a high cure rate. However, the parathyroid glands may be found at various anatomical locations and occasionally they are intrathoracic. Read More

    Comparison of two melphalan protocols and evaluation of outcome and prognostic factors in multiple myeloma in dogs.
    J Vet Intern Med 2018 Mar 22. Epub 2018 Mar 22.
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706.
    Background: Multiple myeloma (MM) in dogs typically is treated with melphalan. A daily melphalan dosing schedule reportedly is well tolerated and associated with favorable outcome. Although anecdotally a pulse dose regimen has resulted in successful responses, little long-term outcome and safety data is available regarding this dosing regimen for dogs with MM. Read More

    Use of calcimimetics in children with normal kidney function.
    Pediatr Nephrol 2018 Mar 19. Epub 2018 Mar 19.
    Bone and Mineral Disorders Clinic, Division of Nephrology, Children's Mercy Hospital, University of Missouri at Kansas City, 2401Gillham Road, Kansas City, MO, 64108, USA.
    The calcium-sensing receptor (CaSR) plays an important role in the homeostasis of serum ionized calcium by regulating parathyroid hormone (PTH) secretion and tubular calcium handling. Calcimimetics, which act by allosteric modulation of the CaSR, mimic hypercalcemia resulting in suppression of PTH release and increase in calciuria. Mostly used in children to treat secondary hyperparathyroidism associated with advanced renal failure, we have shown that calcimimetics can also be successfully used in children with bone and mineral disorders in which elevated PTH plays a detrimental role in skeletal pathophysiology in the face of normal kidney function. Read More

    Acantholytic squamous cell carcinoma of the lung with marked lymphogenous metastases and high titers of myeloperoxidase-antineutrophil cytoplasmic antibodies: a case report.
    BMC Cancer 2018 03 16;18(1):300. Epub 2018 Mar 16.
    Department of Radiology, Japanese Red Cross Kochi Hospital, 2-13-51, Shinhonmachi, Kochi-city, Kochi, 780-8562, Japan.
    Background: Acantholytic squamous cell carcinoma (ASQCC), histologically characterized by intercellular bridge loosening, is recognized as a rare variant of squamous cell carcinoma (SQCC). ASQCC may demonstrate a worse prognosis than conventional SQCC. Pulmonary ASQCC is particularly rare; its biological behavior and prognostic data have not been reported. Read More

    Epidemiology, clinical features, and outcome of HTLV-1-related ATLL in an area of prevalence in the United States.
    Blood Adv 2018 Mar;2(6):607-620
    Division of Hematology, Department of Medicine.
    Adult T-cell leukemia/lymphoma (ATLL) is a fatal disease caused by human T-cell leukemia virus type 1 (HTLV-1). We retrospectively analyzed 195 patients with ATLL (lymphomatous n = 96, acute n = 80, unfavorable chronic n = 7, chronic n = 5, smoldering n = 3, and unclassified n = 4) diagnosed between 1987 and 2016 (median age 52 years, 77% Afro-Caribbean). Hypercalcemia was associated with acute ATLL (65%, vs 23% lymphomatous) ( = . Read More

    Electrolyte Abnormalities in Neonates with Probable and Culture-Proven Sepsis and its Association with Neonatal Mortality.
    J Coll Physicians Surg Pak 2018 03;28(3):206-209
    Department of Pediatrics, Fazle Omar Hospital, Chenab Nagar, Rabwah, Pakistan.
    Objective: To ascertain the frequency of electrolyte abnormalities in patients of probable and culture-proven sepsis on admission and assess any association of electrolyte disorders with mortality.

    Study Design: Descriptive study.

    Place And Duration Of Study: NICU, Fazle-Omar Hospital, Rabwah, from October 2015 to September 2016. Read More

    Efficacy of 8 Gy Single Fraction Palliative Radiation Therapy in Painful Bone Metastases: A Single Institution Experience.
    Cureus 2018 Jan 8;10(1):e2036. Epub 2018 Jan 8.
    Department of Radiation Oncology, King Fahad Medical City, Riyadh, Saudi Arabia.
    Introduction Bone metastasis (BM) is a major complication of many solid tumors like breast, prostate, lung and renal cancers. BM leads to serious sequelae of pain, fractures, spinal cord compression and hypercalcemia. Radiotherapy has an established role in relieving pain caused by BM. Read More

    Maternal and Foetal Health Implications of Vitamin D Status during Pregnancy.
    Ann Nutr Metab 2018 13;72(3):179-192. Epub 2018 Mar 13.
    Gynecology Service, Virgen de la Arrixaca Hospital, Murcia, Spain.
    Background: To what extent does the circulating 25-hydroxyvitamin D (25[OH]D) concentration help to meet the physiological needs of humans is an ongoing subject of debate. Remaining unexposed to the sun to reduce melanoma cancer risk, current lifestyle with less out door activities, and increasing obesity rates, which in turn increases the storage of vitamin D in the adipose tissue, are presumably factors that contribute to the substantial upsurge in the prevalence of vitamin D deficiency in humans. Since evidence is lacking regarding the appropriate cut-off points to define vitamin D status during pregnancy, references used to establish the intake recommendations and vitamin D content of prenatal vitamin supplements are quite conservative. Read More

    The safety and effectiveness profile of eldecalcitol in a prospective, post-marketing observational study in Japanese male patients with osteoporosis.
    J Bone Miner Metab 2018 Mar 12. Epub 2018 Mar 12.
    Risk Communication Department, Drug Safety Division, Chugai Pharmaceutical Co., Ltd, 1-1 Nihonbashi-Muromachi, 2-Chome, Chuo-ku, Tokyo, 103-8324, Japan.
    We conducted a post-marketing observational study to investigate the safety and effectiveness of eldecalcitol for the treatment of osteoporosis in a Japanese clinical setting. The observation period was 12 months for women and 36 months for men. The final results for the female patients have already been published. Read More

    Parathyroidectomy in the Management of Secondary Hyperparathyroidism.
    Clin J Am Soc Nephrol 2018 Mar 9. Epub 2018 Mar 9.
    Harold Simmons Center for Kidney Disease Research and Epidemiology, University of California, Irvine, California
    Secondary hyperparathyroidism develops in CKD due to a combination of vitamin D deficiency, hypocalcemia, and hyperphosphatemia, and it exists in nearly all patients at the time of dialysis initiation. There is insufficient data on whether to prefer vitamin D analogs compared with calcimimetics, but the available evidence suggests advantages with combination therapy. Calcium derangements, patient adherence, side effects, and cost limit the use of these agents. Read More

    J Zoo Wildl Med 2018 Mar;49(1):196-200
    An 8 yr, intact male red-rumped agouti ( Dasyprocta leporina) was evaluated for weight loss. Examination revealed poor body condition, hypercalcemia, elevated serum 25-hydroxyvitamin D, metastatic calcification of soft tissues, and hyperechoic kidneys. The diet, formulated for laboratory rodents, contained elevated levels of vitamin D. Read More

    The c-Raf modulator RRD-251 enhances nuclear c-Raf/GSK-3/VDR axis signaling and augments 1,25-dihydroxyvitamin D3-induced differentiation of HL-60 myeloblastic leukemia cells.
    Oncotarget 2018 Feb 19;9(11):9808-9824. Epub 2018 Jan 19.
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA.
    Differentiation therapy is used in cancer treatment. Epidemiologic studies showed that higher vitamin D levels are associated with reduced cancer risks. However, the therapeutic doses needed for differentiation are accompanied by hypercalcemia and intolerable pathological sequelae. Read More

    Skeletal metastasis in renal cell carcinoma: A review.
    Ann Med Surg (Lond) 2018 Mar 31;27:9-16. Epub 2018 Jan 31.
    Aga Khan University Hospital Karachi, Pakistan.
    Background: Renal cell carcinoma account for 3% of all cancers, with peak incidence between 60 and 70 years of age predominantly affecting male population. Renal carcinoma is the most common malignancy of kidney constitutes for 80-90% of renal neoplasm with an overall 45% five years survival rate. Majority are diagnosed incidentally during investigation for other disease process of abdomen. Read More

    Isolated Adrenocorticotropic Hormone Deficiency and Severe Hypercalcemia After Destructive Thyroiditis in a Patient on Nivolumab Therapy With a Malignant Melanoma.
    J Clin Med Res 2018 Apr 18;10(4):358-362. Epub 2018 Feb 18.
    Department of Internal Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan.
    We describe a 58-year-old man with a malignant melanoma metastasis to the liver. After initiation of nivolumab therapy, he developed destructive thyroiditis and subsequently simultaneous isolated adrenocorticotropic hormone (ACTH) deficiency and severe hypercalcemia. Although isolated ACTH deficiency and hypercalcemia due to nivolumab therapy are both rare occurrences, these conditions can often cause a severe clinical course accompanied by a disturbance of consciousness. Read More

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