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    18370 results match your criteria Milk-Alkali Syndrome

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    The effects of high-dose calcitriol and individualized exercise on bone metabolism in breast cancer survivors on hormonal therapy: a phase II feasibility trial.
    Support Care Cancer 2018 Feb 22. Epub 2018 Feb 22.
    Department of Surgery, URMC, Rochester, NY, USA.
    Introduction: Cancer treatment-induced bone loss (CTIBL) is a long-term side effect of breast cancer therapy. Both calcitriol and weight-bearing exercise improve bone metabolism for osteoporotic patients, but are unproven in a breast cancer population. We used a novel high-dose calcitriol regimen with an individualized exercise intervention to improve bone metabolism in breast cancer survivors. Read More

    Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease.
    J Vet Intern Med 2018 Feb 22. Epub 2018 Feb 22.
    Department of Clinical Science and Services, Royal Veterinary College, University of London, London, United Kingdom.
    Background: Hypercalcemia is commonly associated with chronic kidney disease (CKD) in cats.

    Objectives: To explore the calcitonin response to naturally occurring ionized hypercalcemia in cats with azotemic CKD, and to assess the relationship of plasma calcitonin with ionized calcium, alkaline phosphatase (ALP), and urinary calcium excretion.

    Animals: Thirty-three client-owned cats with azotemic CKD and ionized hypercalcemia from first opinion practice. Read More

    Successful hematopoietic stem cell transplantation for osteopetrosis using reduced intensity conditioning.
    Pediatr Blood Cancer 2018 Feb 22. Epub 2018 Feb 22.
    Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah University Medical Center, Jerusalem, Israel.
    Background: Infantile malignant osteopetrosis (IMO) is an autosomal recessive condition characterized by defective osteoclast activity, with hematopoietic bone marrow transplant being the only available cure. Over the past several years, new conditioning regimes and donor options have emerged, thus extending the possibility of cure to a greater number of patients and improving the outcomes of bone marrow transplant. Here we detail the outcomes of bone marrow transplant in a cohort of 31 patients treated with a combination of fludarabine, treosulphan, thiotepa, and antithymocyte globulin. Read More

    Nitrite-induced acute kidney injury with secondary hyperparathyroidism: Case report and literature review.
    Medicine (Baltimore) 2018 Feb;97(8):e9889
    Department of Nephrology, Shandong University Qilu Hospital, Jinan City, China.
    Rationale: Acute kidney injury (AKI) with hyperparathyroidism caused by nitrite was rare, and renal function and parathyroid hormone (PTH) decreased to normal range after therapy.

    Patient Concerns: Acute kidney injury was diagnosed in a 40-year-old male with hyperparathyroidism and cyanosis of his hands and both forearms.

    Diagnoses: The patient ate some recently pickled vegetables, and he experienced nausea, vomiting and diarrhoea without oliguria or anuria; Additionally, his hands and both forearms had a typical blue ash appearance. Read More

    [Hypercalcaemia due to the milk-alkali syndrome].
    Ugeskr Laeger 2018 Feb;180(7)
    This case report is about an 87-year-old woman with Alzheimer's disease and the milk-alkali syndrome, who took calcium carbonate as osteoporosis prophylaxis. We describe, how the milk-alkali syndrome can result in a triad of hypercalcaemia, metabolic alkalosis, and renal insufficiency. The syndrome is now the third most common cause of hypercalcaemia because of the use of calcium carbonate in osteoporosis prophylaxis and treatment, and the syndrome should be considered in patients with hypercalcaemia, as it may result in permanent renal impairment. Read More

    A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling.
    Sci Signal 2018 Feb 20;11(518). Epub 2018 Feb 20.
    Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LJ, UK.
    The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) that signals through Gand Gto stimulate cytosolic calcium (Ca) and mitogen-activated protein kinase (MAPK) signaling to control extracellular calcium homeostasis. Studies of loss- and gain-of-functionmutations, which cause familial hypocalciuric hypercalcemia type 1 (FHH1) and autosomal dominant hypocalcemia type 1 (ADH1), respectively, have revealed that the CaSR signals in a biased manner. Thus, some mutations associated with FHH1 lead to signaling predominantly through the MAPK pathway, whereas mutations associated with ADH1 preferentially enhance Caresponses. Read More

    Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder: Synopsis of the Kidney Disease: Improving Global Outcomes 2017 Clinical Practice Guideline Update.
    Ann Intern Med 2018 Feb 20. Epub 2018 Feb 20.
    Stanford University School of Medicine, Stanford, California (M.B.L.).
    Description: The Kidney Disease: Improving Global Outcomes (KDIGO) 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) is a selective update of the prior CKD-MBD guideline published in 2009. The guideline update and the original publication are intended to assist practitioners caring for adults with CKD and those receiving long-term dialysis.

    Methods: Development of the guideline update followed an explicit process of evidence review and appraisal. Read More

    A Case Report of Compound Heterozygous CYP24A1 Mutations Leading to Nephrolithiasis Successfully Treated with Ketoconazole.
    Case Rep Nephrol Dial 2017 Sep-Dec;7(3):167-171. Epub 2017 Dec 18.
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
    CYP24A1 is an enzyme that inactivates vitamin D. Loss-of-function mutations in this enzyme are rare but have been linked with idiopathic infantile hypercalcemia as well as adult-onset nephrocalcinosis and nephrolithiasis. Genetic testing for this mutation should be considered in the presence of calciuria, elevated serum calcium, elevated 1,25-dihydroxyvitamin D, and suppressed parathyroid hormone. Read More

    Hypercalcemia associated with cosmetic injections: A systematic review.
    Eur J Endocrinol 2018 Feb 16. Epub 2018 Feb 16.
    S Basnet, Internal Medicine, Reading Hospital and Medical Center, Reading, United States.
    Introduction: Cosmetic injections with silicone and polymethylmethacrylate are not FDA-approved for augmentation of body parts such as breast, buttock or legs, but they have been widely used for decades. Cosmetic injections can cause foreign body granulomas and occasionally severe and life-threatening hypercalcemia. We aimed to systematically analyze the published literature on cosmetic injection-associated hypercalcemia. Read More

    Hyperparathyroidism Mimicking Metastatic Bone Disease: A Case Report and Review of Literature.
    J Adolesc Young Adult Oncol 2018 Feb 15. Epub 2018 Feb 15.
    3 Department of Nuclear Medicine, Delhi State Cancer Institute , Delhi, India .
    Multiple osteolytic lesions are usually associated with metastatic involvement of the bone; however, metabolic bone diseases should also be included in the differential diagnosis. In this study, we describe a case of primary hyperparathyroidism (PHPT) with multiple osteolytic lesions that was diagnosed initially as having metastatic bone involvement. The laboratory results showed hypercalcemia and raised alkaline phosphatase along with fibrosis in the bone marrow biopsy with no increase in tumor markers and normal serum protein electrophoresis. Read More

    Canine Clitoral Carcinoma: A Clinical, Cytologic, Histopathologic, Immunohistochemical, and Ultrastructural Study.
    Vet Pathol 2018 Jan 1:300985818759772. Epub 2018 Jan 1.
    6 Department of Small Animal Clinical Science, Institute of Veterinary Science, University of Liverpool, Liverpool, UK.
    Vaginal and vulvar tumors are uncommon in dogs. Knowledge of canine primary clitoral neoplasia is restricted to a few case reports, and only carcinomas have been reported. Cytologic and histologic features reported in the literature seem to overlap with those of canine apocrine gland anal sac adenocarcinoma (AGASA). Read More

    MILK-ALKALI SYNDROME (MAS) as a complication of the treatment of hypoparathyroidism.
    Endokrynol Pol 2018 Feb 14. Epub 2018 Feb 14.
    Warsaw University of Medicine.
    Milk-alkali syndrome (MAS), characterized by renal failure, metabolic alkalosis and hypercalcemia, is a severe and life-threatening complication of the treatment of hypoparathyroidism. The clinical course is often sudden and is not preceded by any prodromal symptoms. Occurrence does not depend on the duration of hypoparathyroidism treatment, although it is closely related to the applied therapy, especially the dose of calcium carbonate and active vitamin D preparations. Read More

    Managing hyperparathyroidism in hemodialysis: role of etelcalcetide.
    Int J Nephrol Renovasc Dis 2018 5;11:69-80. Epub 2018 Feb 5.
    Division of Nephrology, Hennepin County Medical Center, University of Minnesota, Minneapolis, MN.
    Secondary hyperparathyroidism (SHPT) is common in patients receiving maintenance hemodialysis and is associated with adverse outcomes. Currently, SHPT is managed by reducing circulating levels of phosphate with oral binders and parathyroid hormone (PTH) with vitamin D analogs and/or the calcimimetic cinacalcet. Etelcalcetide, a novel calcimimetic administered intravenously (IV) at the end of a hemodialysis treatment session, effectively reduces PTH in clinical trials when given thrice weekly. Read More

    Predictors of Readmission and Reoperation in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism.
    Otolaryngol Head Neck Surg 2018 Feb 1:194599818758019. Epub 2018 Feb 1.
    1 Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
    Objective Identify risk factors for 30-day reoperation and readmission after parathyroidectomy for primary hyperparathyroidism. Study Design Retrospective analysis of the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database from 2012 through 2014. Subjects and Methods Patients undergoing parathyroidectomy and parathyroid reexploration for primary hyperparathyroidism. Read More

    Rare and changeable as a chameleon: paraneoplastic syndromes in renal cell carcinoma.
    World J Urol 2018 Feb 10. Epub 2018 Feb 10.
    Department of Urology, Eberhard Karls University Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany.
    Introduction: Paraneoplastic syndromes (PNS) in renal cell carcinoma (RCC) are important to be recognized by the treating physician, because they may lead to diagnosis of underlying malignant disease. On the other hand, PNS may dominate the clinical picture and can hide the true disorder like a chameleon. When realized, a PNS can be used as a 'neoplastic tumour marker', especially in case of recurrence. Read More

    AP2? Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity.
    Cell Rep 2018 Jan 28;22(4):1054-1066. Epub 2018 Jan 28.
    Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Electronic address:
    Spatial control of G-protein-coupled receptor (GPCR) signaling, which is used by cells to translate complex information into distinct downstream responses, is achieved by using plasma membrane (PM) and endocytic-derived signaling pathways. The roles of the endomembrane in regulating such pleiotropic signaling via multiple G-protein pathways remain unknown. Here, we investigated the effects of disease-causing mutations of the adaptor protein-2 ? subunit (AP2?) on signaling by the class C GPCR calcium-sensing receptor (CaSR). Read More

    Design, synthesis and biological evaluation of non-secosteriodal vitamin D receptor ligand bearing double side chain for the treatment of chronic pancreatitis.
    Eur J Med Chem 2018 Feb 4;146:541-553. Epub 2018 Feb 4.
    State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of New Drug Discovery, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, China. Electronic address:
    Chronic pancreatitis (CP) is a serious disease that characterized by the progressive replacement of functional pancreas tissue by fibrotic tissue. Vitamin D receptor (VDR) plays a critical role in the development of CP, since it inhibits excessive deposition of extracellular matrix (ECM) in activated pancreatic stellate cells (PSCs). Herein, a novel series of non-secosteriodal VDR ligands were designed and synthesized, and their VDR affinity and anti-fibrosis activity were evaluated. Read More

    Renal impairment in hypophosphatasia.
    Arch Pediatr 2017 May;24(5S2):5S93-5S95
    Service de néphrologie rhumatologie dermatologie pédiatriques, centre de référence des maladies rénales rares, hôpital Femme-Mère-Enfant, 59, boulevard Pinel, 69677 Bron Cedex; faculté de médecine Lyon-Est, université de Lyon, INSERM U 1033, LYOS, prévention des maladies osseuses, 69008 Lyon, France. Electronic address:
    Renal impairment in hypophosphatasia (HPP) has been described but remains poorly understood: hypercalciuria, nephrocalcinosis and sometimes even chronic kidney failure secondary to chronic hypercalcemia/hypercalciuria or exposure to toxic agents. The objectives of this review are to describe the different renal lesions observed in HPP, and the therapeutic measures that can be applied (in particular, thiazide diuretics). Read More

    Hypophosphatasia: the contribution of imaging.
    Arch Pediatr 2017 May;24(5S2):5S74-5S79
    Centre de référence pour les maladies rares du métabolisme du calcium et du phosphore, filière OSCAR; unité d'endocrinologie, maladies osseuses, génétique et gynécologie, hôpital des enfants, CHU de Toulouse, TSA 70034, 31059 Toulouse Cedex 09, France; Centre de physiopathologie de Toulouse-Purpan, CPTP, INSERM UMR 1043, université de Toulouse-Paul-Sabatier, 31059 Toulouse, France. Electronic address:
    Radiography and imaging are necessary for the diagnosis of hypophosphatasia (HPP) at all stages of life, from the antenatal period to the complications of adulthood, and in the forms of variable severity. The consequences of alkaline phosphatase activity deficiency, namely defective mineralization and bone fragility, may be detected by radiological tools and share features that distinguish them from other diseases responsible for mineralization defects. Radiography and imaging are also fundamental for the screening and diagnosis of the complications of HPP, some of which are related to the episodes of hypercalcemia and hyperphosphatemia (nephrocalcinosis). Read More

    Perinatal and infantile hypophosphatasia: clinical features and treatment.
    Arch Pediatr 2017 May;24(5S2):5S61-5S65
    Centre de référence maladies osseuses constitutionnelles, Institut Imagine, université Paris-Descartes-Sorbonne-Paris Cité, hôpital Necker-Enfants malades, 149, rue de Sèvres, 75015 Paris, France.
    Hypophosphatasia (HPP) is a rare hereditary disease characterized by defective skeletal mineralization, and with a broad severity spectrum. The perinatal forms, lethal and non-lethal, are associated with severe neonatal respiratory distress, potential seizures, hypotrophy and marked hypotonia. The diagnosis is rapidly suggested by a combination of typical radiological signs, hypercalcemia, hyperphosphatemia and low alkaline phosphatase (ALP) activity. Read More

    Role of fine needle aspiration cytology in diagnosis of brown tumor secondary to parathyroid adenoma.
    J Lab Physicians 2018 Jan-Mar;10(1):118-120
    Department of Pathology, Chirayu Medical College and Hospital, Bhopal, Madhya Pradesh, India.
    Brown tumor (BT) is caused by altered metabolism of calcium resulting from hyperparathyroidism (primary or secondary). The most common cause of hyperparathyroidism is isolated parathyroid adenoma (PA), and the most common symptoms are hypercalcemia related. BT is considered as a late manifestation of PA and usually diagnosed after surgical treatment of the bony lesion. Read More

    Treatment of Metastatic Spindle Epithelial Tumor with Thymus-Like Differentiation (SETTLE) - Long-Term Disease Control by Multimodal Therapy.
    Oncol Res Treat 2018 22;41(1-2):58-60. Epub 2018 Jan 22.
    Oncology, Hematology, Bone marrow Transplantation with section Pneumology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
    Background: Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a very rare tumor that occurs mainly in pediatric patients and young adults. Only few of these patients develops metastatic disease; therefore, clinical data regarding treatment and outcome of metastatic SETTLE are extremely limited. Several chemotherapy agents have been used in SETTLE but due to the limited number of patients no evidence-based therapy exists. Read More

    Hypercalcemia of malignancy treated with cinacalcet.
    Endocrinol Diabetes Metab Case Rep 2017 15;2017. Epub 2017 Dec 15.
    National and Kapodistrian University of Athens, First Department of Internal Medicine, Laikon Hospital, School of Medicine, Athens, Greece.
    Hypercalcemia of malignancy is the most common cause of hypercalcemia in hospitalized patients. It is associated with a poor prognosis, since it reflects an advanced cancer stage. Among all cancer in females, breast cancer is the most common malignancy, and it has the highest prevalence of hypercalcemia. Read More

    Single-center Experience in Treating Patients With t(4;14) Multiple Myeloma With and Without Planned Frontline Autologous Stem Cell Transplantation.
    Clin Lymphoma Myeloma Leuk 2018 Jan 5. Epub 2018 Jan 5.
    Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, ON, Canada. Electronic address:
    Background: Translocation t(4;14) has traditionally been classified as a high-risk cytogenetic feature in patients with multiple myeloma with shortened progression-free (PFS) and overall survival (OS) despite initial response to treatment. Recent data have shown an improved long-term survival in these patients treated with novel agents, such as bortezomib.

    Patients And Methods: We conducted a retrospective study on our patients with t(4;14) multiple myeloma treated with bortezomib-based induction between July 1, 2006 and June 30, 2014 to assess the real-world outcomes of these patients in a tertiary center. Read More

    Investigating the roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammation by vitamin D.
    Arch Dermatol Res 2018 Feb 1. Epub 2018 Feb 1.
    Telethon Kids Institute, University of Western Australia, 100 Roberts Rd, Subiaco, Perth, WA, 6008, Australia.
    Topical application of biologically active vitamin D [1,25-dihydroxyvitamin D (1,25(OH)D)], or low-calcemic analogues, curb skin inflammation through mechanisms that involve migratory dendritic cells (DCs) and regulatory T (T) cells. 1,25(OH)D also promotes immunoregulation by mast cells, and inhibits the development of T helper type-9 (Th9) cells that secrete interleukin-9 (IL-9). Here, we investigated the ability of topical 1,25(OH)D to suppress contact dermatitis through an IL-9-dependent process, examining mast cells and IL-9-secreting T cells. Read More

    Pulse versus daily oral Alfacalcidol treatment of secondary hyperparathyroidism in hemodialysis patients: a randomized controlled trial.
    Int J Nephrol Renovasc Dis 2018 15;11:25-32. Epub 2018 Jan 15.
    Public Health Department, College of Health Sciences, Qatar University, Doha, Qatar.
    Background: Secondary hyperparathyroidism is a common complication of chronic kidney disease and is managed using vitamin D replacement therapy. Very few studies have examined the effectiveness of pulse alfacalcidol therapy in comparison to daily oral alfacalcidol therapy in suppressing serum parathyroid hormone (PTH) levels in hemodialysis patients. The aim of this randomized controlled trial was to replicate the findings of prior studies comparing effectiveness of pulse oral alfacalcidol therapy versus daily oral alfacalcidol therapy in suppressing PTH after 13 weeks of therapy using a Palestinian sample of hemodialysis patients, and to identify demographic and biomedical characteristics of patients that are independently associated with PTH levels. Read More

    Anesthetic management of primary hyperparathyroidism during pregnancy: A case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9390
    Department of Anesthesiology, Peking University Third Hospital, Beijing, China.
    Rationale: Primary hyperparathyroidism (PHPT) during pregnancy is rare. Nevertheless, hypercalcemia secondary to gestational PHPT may be masked by physiological changes in calcium homeostasis during pregnancy. Gestational PHPT constitutes a serious danger to mother and fetus. Read More

    Skeletal-related events and overall survival of patients with bone metastasis from nonsmall cell lung cancer - A retrospective analysis.
    Medicine (Baltimore) 2017 Dec;96(51):e9327
    The Tumor Hospital Affiliated to Harbin Medical University, Harbin, China.
    Because of improving treatments and survival, 40% to 58% of patients with bone metastases from nonsmall cell lung cancer (NSCLC) will suffer from at least one skeletal-related event (SRE), affecting their quality of life, but the natural history of SRE is poorly understood. The study aimed to examine the factors involved in SRE-free survival (SRS) and overall survival (OS) of patients with NSCLC and bone metastases.This was a retrospective study of 211 patients with bone metastasis from NSCLC and treated at the Tumor Hospital Affiliated to Harbin Medical University between January 2007 and January 2012. Read More

    Sarcoidosis and spondyloarthritis: A coincidence or common etiopathogenesis?
    Caspian J Intern Med 2018 ;9(1):100-103
    Department of Rheumatology, Kassab Institute of Orthopedics, Manouba. Tunisia.
    Background: Sarcoidosis is a multisystem granulomatous disease. Co-existence with spondyloarthritis (SA) has been more described as an adverse effect of anti-TNF α therapy than an association. We report herein a case of a typical sarcoidosis confirmed by histological proofs and an advanced SA with a bamboo column. Read More

    Superior mediastinal typical carcinoid detected by 99mTc-MIBI SPECT/CT imaging: A case report.
    Medicine (Baltimore) 2017 Dec;96(52):e9457
    Rationale: This is a rare case of mediastinal typical carcinoid tumor with elevated parathyroid hormone (PTH) and hypercalcemia detected by Tc -methoxy-isobutyl-isonitrile(Tc-MIBI) single photon emission computed tomography/computed tomography (SPECT/CT) imaging.

    Patient Concerns: A 65-year-old male patient presented with hypercalcemia and elevated PTH.

    Diagnoses: The preoperative diagnosis was ectopic parathyroid adenoma in the right superior mediastinum. Read More

    A rare case report of multiple myeloma presenting with paralytic ileus and type II respiratory failure due to hypercalcemic crisis.
    Medicine (Baltimore) 2017 Dec;96(52):e9215
    Department of Gastrointestinal Surgery, First Hospital of Jilin University.
    Rationale: Paralytic ileus is characterized by the signs and symptoms of intestinal obstruction but without any mechanical lesions in the intestinal lumen. Several medical and surgical conditions can lead to this ailment, such as electrolyte disturbances that impair intestinal motility. However, hypercalcemia secondary to multiple myeloma as a major cause of paralytic ileus has rarely been reported. Read More

    A Fatal Case of Amlodipine Toxicity Following Iatrogenic Hypercalcemia.
    Cardiovasc Toxicol 2018 Jan 30. Epub 2018 Jan 30.
    Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Koodakyar Ave., Daneshju Blvd., Velenjak, Tehran, 1985717443, Iran.
    Using calcium salts in management of amlodipine overdose is challenging. A 25-year-old male with known history of adult polycystic kidney disease presented with hypotension, tachycardia, and intact neurological status after ingestion of 450 mg of amlodipine. Immediately, normal saline infusion and norepinephrine were initiated. Read More

    Impact of admission serum calcium levels on mortality in hospitalized patients.
    Endocr Res 2018 Jan 30:1-8. Epub 2018 Jan 30.
    d Division of Pulmonary and Critical Care Medicine, Department of Medicine , Mayo Clinic , Rochester , MN, USA.
    Objectives: To assess the relationship between admission serum calcium levels and in-hospital mortality in all hospitalized patients.

    Methods: All adult hospitalized patients who had admission serum calcium levels available between years 2009 and 2013 were enrolled. Admission serum calcium was categorized based on its distribution into six groups (<7. Read More

    Sarcoid Myopathy Mimicking Polymyositis: A Case Report and Pool Analysis of the Literature Reviews.
    Acta Med Iran 2017 Dec;55(12):800-806
    Department of Pathology, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.
    A 59-year-old man presented with proximal myopathy, myalgia, and weight loss, with the initial markedly elevated serum creatine kinase at 11,000 U/L. Due to his refusal for muscle biopsy, he was initially treated as inflammatory myositis and responded well with the corticosteroids. However, he subsequently had a relapse of the symptoms with more extensive systemic involvement, i. Read More

    Hypercalcemia, hyperkalemia and supraventricular tachycardia in a patient with subcutaneous fat necrosis.
    J Pediatr Endocrinol Metab 2018 Jan 26. Epub 2018 Jan 26.
    Rutgers Robert Wood Johnson Medical School, Department of Pediatrics, Division of Pediatric Endocrinology, New Brunswick, NJ, USA.
    Background: Subcutaneous fat necrosis (SCFN) is a rare, self-limiting condition that has been associated with several complications including hypercalcemia.

    Case Presentation: We present the case of a 6-week-old male who presented to his pediatrician with a dime-sized erythematous nodule consistent with SCFN, who was also found to have supraventricular tachycardia (SVT). Laboratory findings revealed hypercalcemia and hyperkalemia. Read More

    Right orbital edema masquerading a hematologic malignancy.
    SAGE Open Med Case Rep 2018 10;6:2050313X17751838. Epub 2018 Jan 10.
    Division of Hematology/Oncology, Einstein Medical Center, Philadelphia, PA, USA.
    Introduction: Multiple myeloma is caused by abnormal proliferation of plasma cells that affects more commonly African Americans. It classically presents with hypercalcemia, renal failure, anemia, and lytic bone lesions. The aim of this article is to present an unusual case of a 63-year-old African-American female with multiple myeloma who presented with worsening right-sided eye swelling for the past 3 weeks and to briefly review ophthalmologic manifestations of multiple myeloma. Read More

    Mechanisms of Hypercalcemia in Non-Hodgkin Lymphoma and Associated Outcomes: A Retrospective Review.
    Clin Lymphoma Myeloma Leuk 2018 Feb 30;18(2):e123-e129. Epub 2017 Dec 30.
    Department of Internal Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI; Division of Hematology and Oncology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI. Electronic address:
    Introduction: The etiology of hypercalcemia in non-Hodgkin lymphoma (NHL) has been most often attributed to either elevated serum levels of 1,25-dihydroxycholecalciferol (calcitriol) or parathyroid-related protein (PTHrP). In a single-center retrospective review, we evaluated the incidence of, and outcomes associated with, hypercalcemia in NHL.

    Patients And Methods: The medical records of patients with a histologically confirmed diagnosis of NHL and ≥ 1 episode of hypercalcemia were evaluated for demographic and lymphoma-specific factors, including the response to therapy and overall survival. Read More

    Trends in multiple myeloma presentation, management, cost of care, and outcomes in the Medicare population: A comprehensive look at racial disparities.
    Cancer 2018 Jan 23. Epub 2018 Jan 23.
    Division of Hematology-Oncology, Mayo Clinic, Jacksonville, Florida.
    Background: Outcomes have improved significantly in multiple myeloma (MM), but racial disparities in health care access and survival exist. A comprehensive analysis exploring MM care and racial disparities is warranted.

    Methods: Patients with MM from 1991 to 2010 in the Surveillance, Epidemiology, and End Results-Medicare database were evaluated for racial trends in clinical myeloma-defining events (MDEs), the receipt of treatment (drugs and stem cell transplantation; [SCT]), the cost of care, and overall survival (OS). Read More

    Neonatal severe hyperparathyroidism secondary to a novel homozygousgene mutation.
    Clin Cases Miner Bone Metab 2017 Sep-Dec;14(3):354-358. Epub 2017 Dec 27.
    King Faisal Specialist Hospital and Research Centre Riyadh, Saudi Arabia.
    Neonatal severe hyperparathyroidism (NSHPT) is a rare autosomal recessive disease. Children present within the first 6 months of life and more commonly in the first few weeks. Common presentation is poor feeding, polyuria, dehydration, lethargy, failure to thrive, hypotonia, gastrointestinal dysmotility, osteopenia and symptoms of respiratory distress due to a poorly developed chest cage. Read More

    Calcitriol-mediated hypercalcemia secondary to granulomatous disease caused by soft-tissue filler injection: a case report.
    Clin Cases Miner Bone Metab 2017 Sep-Dec;14(3):340-346. Epub 2017 Dec 27.
    Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA.
    Soft-tissue filler (STF) injections have been used worldwide for cosmetic reasons. In most cases, they are not approved by the United States Food and Drug Administration (FDA). Regulatory boards in Latin American countries do not allow the medical use of STF injections; however, these injections are still widely used. Read More

    Parathyroid carcinoma: an unusual presentation of a rare neoplasm.
    Ger Med Sci 2017 28;15:Doc21. Epub 2017 Dec 28.
    National Institute of Pathology, ICMR, Safdarjung Hospital Campus, New Delhi, India.
    Parathyroid carcinoma is an extremely rare malignant endocrine neoplasm that is very challenging in its diagnosis as well as its treatment. Clinically the disease is detected earlier in patients who present with hyperparathyroidism with signs of profound hypercalcemia. Differentiation between benign and malignant disease of the parathyroid is challenging both for the clinician and for the pathologist. Read More

    Parathyroid carcinoma: From a case report to a review of the literature.
    Int J Surg Case Rep 2018 22;42:214-217. Epub 2017 Nov 22.
    Serviço de Cirurgia Geral, Centro Hospitalar do Porto, Hospital Santo António, Porto, Portugal.
    Introduction: Parathyroid carcinoma is a rare endocrine malignancy. The reported incidence is from 0.5 to 5% of primary hyperparathyroidism cases in various series. Read More

    Hypercalcemia of Malignancy: An Emergency Medicine Simulation.
    Cureus 2017 Nov 15;9(11):e1847. Epub 2017 Nov 15.
    Faculty of Medicine, Memorial University of Newfoundland.
    Hypercalcemia is a poor prognostic factor associated with malignancy. The signs and symptoms of hypercalcemia that the patients present to the emergency department are vague and often overlap with the general symptoms of cancer itself or the adverse effects of the chemotherapy. Given that the development of hypercalcemia of malignancy can present with imminent danger to the patient and is a treatable condition, emergency physicians should know how to recognize and treat it. Read More

    Vitamin D Toxicity: A 16-Year Retrospective Study at an Academic Medical Center.
    Lab Med 2018 Jan 13. Epub 2018 Jan 13.
    Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA.
    Background: Interest in vitamin D has increased during the past 2 decades, with a corresponding increase in laboratory testing of 25-hydroxyvitamin D [25(OH)D]. The vast majority of specimens tested display normal or deficient levels of 25(OH)D; concentrations rarely fall in the potentially toxic range.

    Methods: We performed a retrospective investigation of elevated 25(OH)D levels during a 16-year period at the University of Iowa Hospitals and Clinics (UIHC), a 734-bed tertiary-/quaternary-care academic medical center in the midwestern United States. Read More

    Hypercalcaemic Pancreatitis, Adrenal Insufficiency, Autoimmune Thyroiditis and Diabetes Mellitus in a girl with Probable Sarcoidosis.
    Int J Endocrinol Metab 2017 Oct 22;15(4):e57199. Epub 2017 Aug 22.
    Department of Paediatric Endocrinology, Alder Hey Children's Hospital, Liverpool, UK.
    Introduction: Sarcoidosis is a multisystemic granulomatous disease with diverse and often non-specific symptoms during childhood. The clinical manifestations sometimes include endocrinopathies related to sarcoid infiltration of various endocrine organs, but more commonly due to the associated autoimmune endocrine disorders. There are only a few reports of multiple autoimmune and non-autoimmune endocrine problems occurring simultaneously in patients with sarcoidosis. Read More

    Association of Pre-ESRD Serum Calcium with Post-ESRD Mortality Among Incident ESRD Patients: a Cohort Study.
    J Bone Miner Res 2018 Jan 17. Epub 2018 Jan 17.
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine, Orange, CA, USA.
    Albumin-corrected serum calcium (cSCa) decline at late stages of chronic kidney disease and rise after dialysis initiation. While hypercalcemia is associated with higher mortality in end-stage renal disease (ESRD), there are scarce data on the impact of pre-ESRD cSCa on post-ESRD mortality. Therefore, we used a large national cohort of 21,826 US veterans with incident ESRD who transitioned to dialysis in all US Department of Veterans Affairs healthcare facilities over 2009-2014 to examine the associations with all-cause and cause-specific post-ESRD mortality of (1) cSCa concentrations averaged over the last six months and (2) its rate of decline during the last 12 months before dialysis initiation. Read More

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