18,924 results match your criteria Milk-Alkali Syndrome


Hypercalcemia associated with squamous cell carcinoma of renal pelvis: A case and review of the literature.

J Cancer Res Ther 2019 Mar;15(Supplement):S170-S172

Department of Medical Oncology, Akdeniz University School of Medicine, Antalya, Turkey.

Renal pelvis squamous cell carcinoma (RSCC) is a rare tumor. It starts with nonspecific symptoms and it is usually at an advanced stage with a poor prognosis at the time of diagnosis. SCC-associated hypercalcemia is a well-known paraneoplastic syndrome; however RSCC-associated hypercalcemia is a rare condition. Read More

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http://dx.doi.org/10.4103/0973-1482.187236DOI Listing

Iatrogenic Hypercalcemia Postrenal Transplantation.

Kidney Int Rep 2019 Mar 19;4(3):487-490. Epub 2018 Nov 19.

Department of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.ekir.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409389PMC

A Novel Mutation of the Calcium-Sensing Receptor Gene Causing Familial Hypocalciuric Hypercalcemia Complicates Medical Followup after Roux-en-Y Gastric Bypass: A Case Report and a Summary of Mutations Found in the Same Hospital Laboratory.

Case Rep Endocrinol 2019 13;2019:9468252. Epub 2019 Feb 13.

Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Denmark.

Heterozygous inactivating mutations in the calcium-sensing receptor (CaSR) gene are known to cause familial hypocalciuric hypercalcemia (FHH), usually a benign form of hypercalcemia without symptoms of a disrupted calcium homeostasis. FHH can be mistaken for the more common primary hyperparathyroidism (PHPT), for which surgical treatment may be needed. We describe a case of a 36-year-old woman with hypercalcemia and elevated PTH, initially suspected of having PHPT. Read More

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http://dx.doi.org/10.1155/2019/9468252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393866PMC
February 2019
1 Read

A case of Pneumocystis pneumonia, with a granulomatous response and Vitamin D-mediated hypercalcemia, presenting 13 years after renal transplantation.

Transpl Infect Dis 2019 Mar 20:e13081. Epub 2019 Mar 20.

Department of Internal Medicine, Division of Infectious Disease, University of Wisconsin, School of Medicine and Public Health, Madison, WI, USA.

Vitamin D-mediated hypercalcemia is an uncommon complication of Pneumocystis infection. A granulomatous response resulting from Pneumocystis infection is also atypical. In this report, we describe an exceptional case of granulomatous Pneumocystis pneumonia associated with vitamin D-mediated hypercalcemia, in a patient who presented unusually late after renal transplantation. Read More

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http://dx.doi.org/10.1111/tid.13081DOI Listing

Hypercalcemia in Metaplastic Squamous Cell Carcinoma of the Breast.

Am J Case Rep 2019 Mar 20;20:366-369. Epub 2019 Mar 20.

Division of Surgical Oncology, Rush University Medical Center, Chicago, IL, USA.

BACKGROUND Metaplastic breast carcinoma is a rare entity characterized by rapid growth and heterogeneous histological features. It comprises less than 1% of all breast cancers, and no definitive treatment has yet been identified. CASE REPORT We describe here a patient who presented with acute hypercalcemia and was found to have a large ulcerated breast mass. Read More

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https://www.amjcaserep.com/abstract/index/idArt/912427
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http://dx.doi.org/10.12659/AJCR.912427DOI Listing
March 2019
1 Read

Atypical presentation of pneumonia in a patient with rheumatoid arthritis treated with tofacitinib: a case presentation.

BMC Rheumatol 2018 3;2:34. Epub 2018 Nov 3.

3Department of Rheumatology, Immunology and Rehabilitation, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

Background: We report the case of a patient with rheumatoid arthritis (RA) treated with tofacitinib who developed severe pneumonia (PJP) with an atypical clinical presentation.

Case Presentation: A 78-year old male patient with RA treated with tofacitinib, methotrexate (MTX) and low dose corticosteroids was admitted to the hospital with arthralgia and nausea. Laboratory findings revealed hypercalcemia with normal levels of parathyroid hormone (PTH) and elevated 1,25-(OH) vitamin D levels. Read More

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https://bmcrheumatol.biomedcentral.com/articles/10.1186/s419
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http://dx.doi.org/10.1186/s41927-018-0042-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390573PMC
November 2018
2 Reads

Diagnosis and Management of Oncologic Emergencies.

West J Emerg Med 2019 Mar 14;20(2):316-322. Epub 2019 Feb 14.

Virginia Tech Carilion School of Medicine, Department of Emergency Medicine, Roanoke, Virginia.

Oncologic emergencies may be seen in any emergency department and will become more frequent as our population ages and more patients receive chemotherapy. Life-saving interventions are available for certain oncologic emergencies if the diagnosis is made in a timely fashion. In this article we will cover neutropenic fever, tumor lysis syndrome, hypercalcemia of malignancy, and hyperviscosity syndrome. Read More

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https://escholarship.org/uc/item/3x84z2bq
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http://dx.doi.org/10.5811/westjem.2018.12.37335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404710PMC
March 2019
2 Reads

Rare complication of milk-alkali ingestion: severe pancreatitis and acute kidney injury in a chronic hypocalcaemic patient with DiGeorge's syndrome.

BMJ Case Rep 2019 Mar 15;12(3). Epub 2019 Mar 15.

Department of Internal Medicine, St Vincent Charity Medical Center, Cleveland, Ohio, USA.

Injudicious use of over-the-counter calcium supplements has resulted in increased incidences of hypercalcaemia and related complications. We present a case of acute pancreatitis in a chronic hypocalcaemic patient of DiGeorge's syndrome. The patient came into the ED with sepsis syndrome, right upper quadrant and epigastric pain and no obvious source of infection. Read More

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http://dx.doi.org/10.1136/bcr-2018-226761DOI Listing
March 2019
1 Read

Review of paraneoplastic syndromes in children.

Pediatr Radiol 2019 Mar 16. Epub 2019 Mar 16.

Department of Radiology, Boston Children's Hospital, 300 Longwood Ave., Boston, MA, 02215, USA.

Paraneoplastic syndromes are defined as clinical syndromes that are not related to direct tumor invasion or compression but are secondary to tumor secretion of functional peptides/hormones or related to immune cross-reactivity with normal host tissue. Paraneoplastic syndromes have a wide range of presentations and can present before the primary malignancy or tumor recurrence is diagnosed. They can mimic non-neoplastic processes, making detection, diagnosis and treatment difficult. Read More

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http://dx.doi.org/10.1007/s00247-019-04371-yDOI Listing
March 2019
3 Reads

Role of Bisphosphonates in Breast Cancer Therapy.

Curr Treat Options Oncol 2019 Mar 14;20(4):26. Epub 2019 Mar 14.

Division of Medical Oncology, University of Toronto and Princess Margaret Cancer Centre, 700 University Ave, 7-721, Toronto, ON, M5G 2M9, Canada.

Opinion statement Bisphosphonates are utilized routinely in breast cancer. In metastatic disease with bone involvement, bisphosphonates prevent or delay skeletal-related events and can improve pain control. Different agents have shown benefit compared with placebo or no treatment. Read More

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http://dx.doi.org/10.1007/s11864-019-0623-8DOI Listing
March 2019
2 Reads

Patiromer Acetate Induced Hypercalcemia: An Unreported Adverse Effect.

Case Rep Nephrol 2019 4;2019:3507407. Epub 2019 Feb 4.

Northeast Ohio Medical University, Department of Medicine, Rootstown, Ohio, USA.

Hyperkalemia, a potential life threating condition, is a commonly encountered problem in chronic kidney disease (CKD) patients. Patiromer acetate, a nonabsorbable cation exchange polymer, is a gastrointestinal agent for chronic therapy in patients with persistent hyperkalemia. Patiromer is generally well tolerated in patients; common side effects are gastrointestinal, such as diarrhea, constipation, flatulence, and vomiting. Read More

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http://dx.doi.org/10.1155/2019/3507407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378798PMC
February 2019
1 Read

Effect of Parathyroidectomy on cardiovascular risk factors in primary hyperparathyroidism: A randomised clinical trial.

J Clin Endocrinol Metab 2019 Mar 12. Epub 2019 Mar 12.

Department of Clinical Medicine, Aarhus University and Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark.

Context: It remains unclear whether risk of cardiovascular diseases is increased in patients with mild (˂1.45 mmol/l) to moderate (≥1.45-1. Read More

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http://dx.doi.org/10.1210/jc.2018-02456DOI Listing
March 2019
1 Read

Efficacy and safety of abaloparatide for the treatment of post-menopausal osteoporosis.

Expert Opin Pharmacother 2019 Mar 11:1-7. Epub 2019 Mar 11.

a Department of Medicine, Surgery and Neurosciences , University of Siena , Siena , Italy.

Introduction: Osteoporosis is a skeletal disorder characterized by loss of bone mass and strength affecting up to 30-50% of postmenopausal women worldwide. Current therapeutic options include antiresorptives such as aminobisphosphonates or denosumab and osteoanabolic compounds such as teriparatide. Areas covered: In this review, the authors summarize the clinical development, safety and efficacy profile of abaloparatide, a new osteoanabolic agent recently marketed in the US for the treatment of postmenopausal osteoporosis in women who are at high risk for fracture or who fail antiresorptive therapy. Read More

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http://dx.doi.org/10.1080/14656566.2019.1583208DOI Listing

Morbidity and Mortality: A Case Report of Metastatic Bone Disease.

Cureus 2018 Dec 27;10(12):e3781. Epub 2018 Dec 27.

Department of Internal Medicine, The Wright Center for Graduate Medical Education, Scranton, USA.

Metastatic prostate cancer and multiple myeloma (MM) usually present with bone lesions, posing a diagnostic challenge in males presenting in late stages. In this case report, an 86-year-old male who had not seen a physician in over 30 years presented with complaints of hip pain and progressive difficulty in walking for three weeks. Outpatient X-ray of the right hip showed multiple lytic bone lesions, raising suspicion of MM. Read More

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https://www.cureus.com/articles/12364-morbidity-and-mortalit
Publisher Site
http://dx.doi.org/10.7759/cureus.3781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395020PMC
December 2018
3 Reads

Management of Endocrine Emergencies in the ICU.

Authors:
Judith Jacobi

J Pharm Pract 2019 Mar 10:897190019834771. Epub 2019 Mar 10.

1 Pharmacy Department, Indiana University Health Methodist Hospital, Indianapolis, IN, USA.

Endocrine emergencies are frequent in critically ill patients and may be the cause of admission or can be secondary to other critical illness. The ability to anticipate endocrine abnormalities such as adrenal excess or , hypothyroidism, can mitigate their duration and severity. Hyperglycemic crisis may trigger hospital and intensive care unit (ICU) admission and may be life threatening. Read More

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http://dx.doi.org/10.1177/0897190019834771DOI Listing
March 2019
1 Read

Characterization of Cancer-Induced Nociception in a Murine Model of Breast Carcinoma.

Cell Mol Neurobiol 2019 Mar 8. Epub 2019 Mar 8.

Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil.

Severe and poorly treated pain often accompanies breast cancer. Thus, novel mechanisms involved in breast cancer-induced pain should be investigated. Then, it is necessary to characterize animal models that are reliable with the symptoms and progression of the disease as observed in humans. Read More

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http://dx.doi.org/10.1007/s10571-019-00666-8DOI Listing
March 2019
1 Read

New Concepts About Familial Isolated Hyperparathyroidism.

Authors:
Stephen J Marx

J Clin Endocrinol Metab 2019 Mar 8. Epub 2019 Mar 8.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD.

Context: Familial isolated hyperparathyroidism (FIHP) is defined as familial primary hyperparathyroidism (FH) without a characteristic extra-parathyroidal feature of a more complex hyperparathyroid syndrome. During 80 years, new concepts of FIHP have been developed within this definition. FIHP has been difficult to study due to small kindreds and mildly symptomatic cases. Read More

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http://dx.doi.org/10.1210/jc.2018-02789DOI Listing
March 2019
1 Read

ERRATUM FOR "PTHrP-Mediated Hypercalcemia: Causes and Survival in 138 Patients".

Authors:

J Clin Endocrinol Metab 2019 Mar 8. Epub 2019 Mar 8.

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http://dx.doi.org/10.1210/jc.2019-00525DOI Listing
March 2019
1 Read

[Rhabdomyolysis and severe hypercalcemia. Report of one case].

Rev Med Chil 2019 ;147(1):125-129

Departamento de Nefrología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.4067/S0034-98872019000100125DOI Listing
March 2019
1 Read

Resolution of Raynaud's Symptoms after Parathyroidectomy.

Am Surg 2018 Aug;84(8):e323-e324

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August 2018
1 Read

Vitamin D Intoxication In 7-Month-Old Infant With Recommended Daily Intake Of Vitamin D.

J Ayub Med Coll Abbottabad 2018 Oct-Dec;30(Suppl 1)(4):S673-S675

Children Hospital & Institute of Child Health Lahore, Pakistan.

Over the past decade there is increased use of vitamin D supplementation because of its benefits on bone health. It is a fat-soluble vitamin and cannot be excreted from the body. There is need for monitoring 25-hydroxyvitamin D levels in infants and children who receive long-term vitamin D supplementation at or above the upper level intake that is currently recommended. Read More

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March 2019
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Pulmonary function abnormalities are common in patients with multiple myeloma and are independently associated with worse outcome.

Ann Hematol 2019 Mar 5. Epub 2019 Mar 5.

Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 80 Vasilissis Sofias, 11258, Athens, Greece.

Pre-existing pulmonary disease may affect treatment choices, toxicity, and survival of patients with multiple myeloma (MM). However, data on the prognostic value of pulmonary function tests (PFTs) in myeloma patients' outcome, at the time of initial assessment of newly diagnosed patients, are scarce. Here, we prospectively performed PFTs in 121 newly diagnosed MM patients, before initiation of treatment, and we evaluated possible associations of lung function with their outcomes. Read More

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http://dx.doi.org/10.1007/s00277-019-03641-xDOI Listing
March 2019
3 Reads

Importance of Parathyroid Hormone Needle Aspiration Washout in Adenoma Localization in Primary Hyperparathyroidism.

Med Sci Monit 2019 Mar 5;25:1694-1698. Epub 2019 Mar 5.

Department of Nuclear Medicine, Gazi Yaşargil Training and Research Hospital, Yenişehir, Diyarbakır, Turkey.

BACKGROUND Primary hyperparathyroidism is an endocrine disease characterized by excessive secretion of parathyroid hormone and hypercalcemia. Although scintigraphy is commonly used for pre-operative localization, it does not always localize the parathyroid lesion. In such patients, ultrasonography can visualize the suspected lesion and needle washout sample for parathyroid hormone titer can be used to confirm parathyroid tissue. Read More

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http://dx.doi.org/10.12659/MSM.915192DOI Listing
March 2019
2 Reads

Ectopic Parathyroid Adenoma in Piriform Sinus: Case Report and Review of the Literature.

Ear Nose Throat J 2019 Jan 28;98(1):14-17. Epub 2019 Jan 28.

1 Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.

During routine blood work, a 53-year-old female patient was noted to have asymptomatic hypercalcemia and subsequently found to have hyperparathyroidism. Localization studies for a suspected parathyroid adenoma included Tc Sestamibi scintigraphy, Single Photon Emission Computed Tomography (SPECT)/computed tomography (CT) study, and ultrasound of the neck, which were initially read as negative for parathyroid adenoma. A contrast-enhanced CT scan of the neck was performed to locate the suspected parathyroid adenoma and demonstrated a soft tissue lesion within the right piriform sinus. Read More

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http://dx.doi.org/10.1177/0145561318822933DOI Listing
January 2019
2 Reads

Calcium electroporation for recurrent head and neck cancer: A clinical phase I study.

Laryngoscope Investig Otolaryngol 2019 Feb 3;4(1):49-56. Epub 2019 Jan 3.

Department of Otorhinolaryngology, Head & Neck Surgery and Audiology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark.

Background: Calcium electroporation is a novel cancer treatment, which combines temporary cell permeability from electroporation with a high influx of calcium intracellularly resulting in cancer cell necrosis.

Methods: A phase I trial performing calcium electroporation on 6 patients suffering from recurrent head and neck cancer. In general anesthesia, intratumoral calcium injections were followed by electroporation. Read More

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http://dx.doi.org/10.1002/lio2.233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383303PMC
February 2019
1 Read

Hypercalcemia secondary to excessive self-medication with antacids causing acute pancreatitis: a case report.

Croat Med J 2019 Feb;60(1):42-45

Pietro Vassallo, Department of Surgery, Royal United Hospitals Bath NHS Foundation Trust, Combe Park, Bath, BA1 3NG, United Kingdom,

Excessive self-medication with over-the-counter drugs is an issue commonly encountered by health care professionals. It can result in uncommon presentations of life-threatening illnesses. These medications are frequently overlooked by clinicians when taking histories from patients, and their risks are often downplayed. Read More

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February 2019
4 Reads

Visual Diagnosis: An Infant with Rash and Hypercalcemia.

Pediatr Rev 2019 Mar 1;40(3):e11-e13. Epub 2019 Mar 1.

Department of Pediatric Endocrinology, McGovern Medical School at UT Health, Houston, TX.

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http://dx.doi.org/10.1542/pir.2017-0058DOI Listing
March 2019
2 Reads

Gene Mutation in a Dizygous Twin With Transient Neonatal Hyperparathyroidism.

J Endocr Soc 2019 Mar 3;3(3):602-606. Epub 2019 Jan 3.

Department of Pediatrics, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan.

Maternal-fetal transport of calcium (Ca) is important for bone mineralization in fetal development. Insufficient Ca transport causes transient neonatal hyperparathyroidism (TNHP). Transient receptor potential cation channel, subfamily V, member 6 (TRPV6), has been found to play an important role in the active transport of Ca through the placenta. Read More

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http://dx.doi.org/10.1210/js.2018-00374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389352PMC
March 2019
1 Read

Primary Hyperparathyroidism: Redefining Cure.

Am Surg 2019 Feb;85(2):214-218

Primary hyperparathyroidism is the most common cause of hypercalcemia. Follow-up can be resource-intensive and costly. The aim of this study was to determine if there is a subset of patients who can be defined cured earlier than six months. Read More

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February 2019
3 Reads

Gender differences in bone mineral density in patients with sporadic primary hyperparathyroidism.

Endocrinol Diabetes Metab 2018 Oct 4;1(4):e00037. Epub 2018 Sep 4.

Department of Surgical Oncology The University of Texas MD Anderson Cancer Center Houston Texas.

Context: Primary hyperparathyroidism reduces bone mineral density, which increases the risk of fracture.

Objective: To investigate differences in bone mineral density and clinical characteristics after parathyroidectomy between men and women (premenopausal and postmenopausal) with sporadic primary hyperparathyroidism.

Design: This is a retrospective study of adult patients who underwent parathyroidectomy in a tertiary referral center from 1990 to 2013. Read More

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http://dx.doi.org/10.1002/edm2.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354761PMC
October 2018
1 Read

Ileal Tuberculosis Causing Hypercalcemia and Renal Failure.

Indian J Nephrol 2019 Jan-Feb;29(1):53-56

Department of Nephrology, Aster Medcity, Kochi, Kerala, India.

Hypercalcemia rarely causes acute pancreatitis due to secretory block in the pancreas and damage by accumulated proteases. Hypercalcemia, though described in granulomatous disorders, is uncommon in tuberculosis. Acute kidney injury is known to occur with acute pancreatitis, secondary to sepsis and septic shock; however, acute pancreatitis resulting in acute cortical necrosis is very rare. Read More

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http://dx.doi.org/10.4103/ijn.IJN_426_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375019PMC
March 2019
2 Reads

Management of Post-transplant Hyperparathyroidism and Bone Disease.

Drugs 2019 Feb 27. Epub 2019 Feb 27.

Division of Nephrology and Hypertension, Keck School of Medicine of USC, 2020 Zonal Ave, IRD 806, Los Angeles, CA, 90033, USA.

Significant advances in immunosuppressive therapies have been made in renal transplantation, leading to increased allograft and patient survival. Despite improvement in overall patient survival, patients continue to require management of persistent post-transplant hyperparathyroidism. Medications that treat persistent hyperparathyroidism include vitamin D, vitamin D analogues, and calcimimetics. Read More

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http://dx.doi.org/10.1007/s40265-019-01074-4DOI Listing
February 2019

Extensive osteonecrosis of the maxilla caused by bisphosphonates: Report of a rare case.

J Clin Exp Dent 2019 Feb 1;11(2):e203-e207. Epub 2019 Feb 1.

Oral and Maxillofacial Surgeon of the department of Oral and Maxillofacial Surgery, Universitary Hospital Lauro Wanderley, Federal University of Paraiba.

Bisphosphonates are drugs indicated for the treatment of bone metabolic diseases or malignant hypercalcemia. They are generally well-tolerated drugs, however, recent reports have described osteonecrosis of the jaw bones as a potentially serious complication related to the long-term use of these drugs. We report a case of severe osteonecrosis in a 52-years-old white woman that was taking bisphosphonates (zoledronic acid and alendronate) for the management of osteoporosis. Read More

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http://dx.doi.org/10.4317/jced.55151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383896PMC
February 2019
1 Read

Three Therapeutic Strategies: Cinacalcet, Paricalcitol or Both in Secondary Hyperparathyroidism Treatment in Hemodialysed Patients During 1-Year Observational Study-A Comparison.

Front Endocrinol (Lausanne) 2019 5;10:40. Epub 2019 Feb 5.

Fresenius Medical Care Polska S.A, Poznan, Poland.

Secondary hyperparathyroidism (sHPT) is a common hormonal complication of chronic kidney disease. There are several therapeutic options for sHPT management aiming at calcium-phosphorus balance normalization and decrease of parathormone secretion. The aim of this retrospective, observational study was the outcome assessement of three most common therapeutic strategies of secondary hyperparathyroidism treatment with vitamin D receptor activator-paricalcitol, calcimimetic-cinacalcet or both agents administered together during in 12-months period. Read More

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http://dx.doi.org/10.3389/fendo.2019.00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371033PMC
February 2019
3 Reads

Gastrointestinal Neuroendocrine Tumor, Colon Adenocarcinoma, and Hyperparathyroidism: An Unorthodox Synchronism.

Cureus 2018 Dec 14;10(12):e3731. Epub 2018 Dec 14.

Internal Medicine, Jinnah Sindh Medical University, Karachi, PAK.

Synchrony of colorectal adenocarcinoma with neuroendocrine tumor (NET) and hyperparathyroidism with colon adenocarcinoma is a rare entity, reported in a handful of cases. We authors would like to report a rare case of coexistence of poorly differentiated colon adenocarcinoma, NET of appendix and hyperparathyroidism. A 43-year-old Caucasian female was diagnosed with metastatic colon adenocarcinoma involving the caecum and appendiceal orifice. Read More

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http://dx.doi.org/10.7759/cureus.3731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384038PMC
December 2018
1 Read

Characterization of a novel CDC73 gene mutation in a hyperparathyrodism-jaw tumor patient affected by parathyroid carcinoma in the absence of somatic loss of heterozygosity.

Endocr J 2019 Feb 22. Epub 2019 Feb 22.

Department of Surgery and Translational Medicine, University of Florence, Unit of Bone and Mineral Diseases, University Hospital of Florence, Florence 50139, Italy.

Hyperparathyrodism-jaw tumor (HPT-JT) syndrome is an autosomal dominant disorder. Loss of function of the cell division cycle protein 73 homolog (CDC73) gene is responsible for the syndrome. This gene encodes an ubiquitously expressed 531 amino acid protein, parafibromin, that acts as a tumor suppressor. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0387DOI Listing
February 2019
1 Read

[Trends in parathyroid hormone plasma concentration in critically ill patients: prospective observational study].

Wiad Lek 2019;72(1):40-46

Katedra i Klinika Endokrynologii, Diabetologii i Leczenia Izotopami, Uniwersytet Medyczny we Wrocławiu, Wrocław, Polska.

Objective: Introduction: There is no data in the literature regarding trends in parathormone serum concentration assessment in critically ill patients. The aim: To assess the parathyroid hormone plasma concentrations and kinetics in critically ill patients admitted to the intensive care unit due to multiorgan failure.

Patients And Methods: Materials and methods: Thirty multiorgan failure (at least circulatory and respiratory failure) patients were included. Read More

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January 2019

Redundancy Is of No Good; Iatrogenic Hypervitaminosis D: A Rare Case of Persistent Vomiting Due to Hypercalcemia.

Clin Med Insights Case Rep 2019 7;12:1179547619828688. Epub 2019 Feb 7.

Department of Internal Medicine, Jinnah Medical College Hospital, Karachi, Pakistan.

Introduction: Iatrogenic or physician-induced hypervitaminosis D is a rare cause of persistent vomiting. To the best of our knowledge, this is the first case report on iatrogenic hypervitaminosis D presenting with persistent vomiting in Pakistan.

Case Report: We report a rare case of continual vomiting for 15 days in a 48-year-old woman of Pakistani descent. Read More

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http://dx.doi.org/10.1177/1179547619828688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376501PMC
February 2019
1 Read

Vitamin A and Hydrochlorothiazide Causing Severe Hypercalcemia in a Patient With Primary Hyperparathyroidism.

J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709618823805

2 CHI Little Rock Diagnostic Clinic, Little Rock, AR, USA.

Objective: To report a case of severe hypercalcemia, exacerbated by vitamin A supplementation and hydrochlorothiazide, in a patient with primary hyperparathyroidism.

Methods: Clinical and laboratory findings are presented along with response to therapy.

Results: A 68-year-old white female presented to the emergency department complaining of nausea, vomiting, and altered mental status. Read More

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http://dx.doi.org/10.1177/2324709618823805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350155PMC
February 2019
2 Reads

Parathyroid Carcinoma and Persistent Hypercalcemia: A Case Report and Review of Therapeutic Options.

Saudi J Med Med Sci 2018 May-Aug;6(2):115-118. Epub 2018 Apr 16.

Department of Endocrinology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.

Parathyroid carcinomas are very uncommon, accounting for 0.1% to 5% of all causes of primary hyperparathyroidism. Parathyroid-jaw tumor syndrome, with a mutation in that encodes parafibromin, is the most common genetic association. Read More

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http://dx.doi.org/10.4103/sjmms.sjmms_104_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196698PMC
April 2018
1 Read

Clinical Profile and Outcome of Parathyroid Adenoma-Associated Pancreatitis.

Saudi J Med Med Sci 2018 May-Aug;6(2):95-99. Epub 2018 Apr 16.

Department of Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, Telangana, India.

Background: Primary hyperparathyroidism due to parathyroid adenoma presenting with pancreatitis as the initial manifestation is rare. The causal relationship between pancreatitis and primary hyperparathyroidism is debatable.

Objective: To study the clinical and biochemical profile of patients with parathyroid adenoma-associated pancreatitis as well as the outcome following parathyroidectomy. Read More

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http://dx.doi.org/10.4103/sjmms.sjmms_80_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196711PMC
April 2018
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Health-Related Quality of Life and Satisfaction With Health Care: Relation to Clinical Stage in Mexican Patients With Multiple Myeloma.

Cancer Control 2019 Jan-Dec;26(1):1073274819831281

1 Unidad de Investigación Biomédica 02, Unidad Médica de Alta Especialidad (UMAE), Hospital de Especialidades (HE), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.

Multiple myeloma (MM) is characterized by bone pain, pathologic fractures, bone destruction, and secondary hypercalcemia, all these conditions impact on health-related quality of life of patients. The objective was to evaluate the global health state and health-related quality of life in a group of patients with MM who attended a tertiary health-care center of the Instituto Mexicano del Seguro Social in Mexico, through the questionnaires designed by European Organization for Research and Treatment of Cancer (EORTC) quality of life group. Exploratory cross-sectional study in patients with MM treated in a Department of Hematology in a High-Specialty Medical Unit was conducted. Read More

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http://dx.doi.org/10.1177/1073274819831281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385332PMC
February 2019
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Gynecological neoplasms associated with paraneoplastic hypercalcemia.

Authors:
D Lim E Oliva

Semin Diagn Pathol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.

Approximately 5% of gynecological malignancies are associated with paraneoplastic hypercalcemia. Awareness of its association with certain tumor types allows for earlier disease detection and facilitates monitoring of treatment response and disease recurrence. We review the salient clinicopathological features, differential diagnosis and management issues in some of these gynecological tumors, namely: small cell carcinoma, hypercalcemic type; ovarian clear cell carcinoma, dysgerminoma and juvenile granulosa cell tumors. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.01.003DOI Listing
February 2019
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Limited clinical utility of intraoperative frozen section during parathyroidectomy for treatment of primary hyperparathyroidism.

Am J Surg 2019 Feb 5. Epub 2019 Feb 5.

Department of Surgery, University of British Columbia & St Paul's Hospital, C303-1081, Burrard Street, Vancouver, BC, V6Z 1Y6, Canada. Electronic address:

Background: This study's objective was to evaluate the utility of intraoperative frozen section (IFS) performed during parathyroidectomy for treatment of primary hyperparathyroidism (PHP), and to identify patients for whom it is most helpful.

Methods: A retrospective chart review was carried out for all patients who underwent parathyroidectomy for treatment of PHP between January 2013 and June 2018.

Results: 262 patients made up the final study population. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2019.01.032DOI Listing
February 2019
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Evaluation of endothelial function and diastolic function in patients with primary hyperparathyroidism before and after parathyroidectomy.

Cir Cir 2019 ;87(2):196-204

Unidad de Investigación en Endocrinología Experimental. Hospital de Especialidades Centro Médico Nacional Siglo XXI. Ciudad de México, México.

Introduction: Primary hyperparathyroidism (PHPT) is the leading cause of outpatient hypercalcemia associated with increased cardiovascular risk. The flow-mediated vasodilation (FMV) has been proposed as a non-invasive method for assessing endothelial function.

Objective: To compare the endothelial dysfunction measured by FMV and diastolic dysfunction in patients with PHPT before and after parathyroidectomy. Read More

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http://dx.doi.org/10.24875/CIRU.18000520DOI Listing
January 2019
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Efficacy and Safety of 90,000 IU versus 300,000 IU Single Dose Oral Vitamin D in Nutritional Rickets: A Randomized Controlled Trial.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):760-765

Department of Radiology, Chacha Nehru Bal Chikitsalaya, Geeta Colony, New Delhi, India.

Aim: To compare efficacy and safety of 90,000 IU versus 300,000 IU oral single dose vitamin D for treatment of nutritional rickets.

Study Design: Randomized controlled trial.

Setting: Tertiary care hospital. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_84_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330863PMC
February 2019
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Fluconazole as a New Therapeutic Tool to Manage Patients With NPTIIc (SLC34A3) Mutation: A Case Report.

Am J Kidney Dis 2019 Feb 11. Epub 2019 Feb 11.

Centre de Référence des Maladies Rénales Rares, filière ORKID, Service de Néphrologie, Rhumatologie et Dermatologie Pédiatriques; Centre de Référence des Maladies Rares du Calcium et du Phosphate, filière OSCAR; Faculté de Médecine Lyon Est, Université Lyon 1, Lyon; INSERM 1033, Prévention des Maladies Osseuses, Lyon, France. Electronic address:

Mutations in the SLC34A3 gene, encoding the sodium/phosphate cotransporter 2C (NPTIIc), induce decreased renal phosphate reabsorption, hypophosphatemia, decreased fibroblast growth factor 23 and parathyroid hormone, and increased 1,25-dihydroxyvitamin D (1,25[OH]D) levels. The complete phenotype is characterized by hypophosphatemia, hypercalciuria, and nephrolithiasis/nephrocalcinosis, leading to chronic kidney disease and osteoporosis in adults. We report a 15-year-old boy referred for nephrocalcinosis. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.026DOI Listing
February 2019
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