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    Calcitriol treatment in metabolic bone disease of prematurity with elevated parathyroid hormone: A preliminary study.
    J Clin Transl Endocrinol 2015 Mar 22;2(1):14-20. Epub 2014 Dec 22.
    Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.
    Objective: To describe the association of calcitriol treatment with the change in parathyroid hormone (PTH) and biochemical markers of bone disease in infants with metabolic bone disease of prematurity (MBD) and secondary hyperparathyroidism.

    Study Design: This retrospective chart review examined serum intact PTH, serum calcium (Ca), serum phosphorus (P), serum alkaline phosphatase (APA), urine calcium/creatinine (UCa/Cr), and tubular reabsorption of phosphate (TRP) in 32 infants prior to and following calcitriol treatment for MBD with PTH >100 pg/ml. 25-hydroxyvitamin D concentrations were recorded. Read More

    Association between Extreme Values of Markers of Chronic Kidney Disease: Mineral and Bone Disorder and 5-Year Mortality among Prevalent Hemodialysis Patients.
    Blood Purif 2017 Nov 22;45(1-3):1-7. Epub 2017 Nov 22.
    Department of Nephrology, Tianjin Union Medicine Center, Tianjin, PR China.
    Background/aims: We examined the association between markers of chronic kidney disease - mineral and bone disorder (CKD-MBD) and mortality in hemodialysis (HD) patients.

    Methods: We retrospectively reviewed the association between markers of CKD-MBD and mortality in 1,126 HD patients from 2009 to 2013 with baseline (B), time-average (TA), and time-dependent (TD) Cox regression models.

    Results: Hypercalcemia (10. Read More

    SMARCA4-Deficient Carcinoma of Unknown Primary Presenting with Fatal Paraneoplastic Hypercalcemia in a Heart Transplant Recipient: First Report in a Male Patient.
    Case Rep Pathol 2017 11;2017:9403467. Epub 2017 Oct 11.
    Department of Cardiac Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, University Hospital of Erlangen, 91054 Erlangen, Germany.
    Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), is a rare SMARCA4-driven aggressive malignancy of young age characteristically associated with paraneoplastic hypercalcemia. Comparable neoplasms/presentations have not been reported in males. A 39-year-old male heart transplant recipient (HTX 40 months previously) presented with multiple liver nodules and hypercalcemic crisis. Read More

    Cancer-related hypercalcemia in oral cancer.
    Int J Oral Maxillofac Surg 2017 Nov 16. Epub 2017 Nov 16.
    Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:
    Cancer-related hypercalcemia (CRH) is a critical paraneoplastic disorder in advanced cancer patients. In clinical practice, patients with CRH have a poor prognosis. The medical records of 3198 oral cancer patients with CRH diagnosed at Taichung Veterans General Hospital from 1 January 2003 to 31 December 2015 were reviewed. Read More

    Denosumab Therapy for Refractory Hypercalcemia Secondary to Squamous Cell Carcinoma of Skin in Epidermolysis Bullosa.
    World J Oncol 2015 Apr 12;6(2):345-348. Epub 2015 Apr 12.
    Department of Paediatric Endocrinology, Alder Hey Children's Hospital, Liverpool L12 2AP, UK.
    Hypercalcemia secondary to malignancy is rare in children and the majority is caused by tumor-produced parathyroid hormone-related protein (PTHrP). We report a case of hypercalcemia refractory to bisphosphonate and corticosteroid therapy, but responsive to denosumab. A 17-year-old boy with epidermolysis bullosa (EB) and advanced squamous cell carcinoma (SCC) of the left leg was referred with severe hypercalcemia (serum calcium, 4. Read More

    Hypercalcemia as a Presenting Clinical Manifestation of Adenocarcinoma of the Colon.
    World J Oncol 2012 Aug 26;3(4):191-193. Epub 2012 Aug 26.
    Internist, Valley View Regional Hospital, 2020 Arlington, Suite 2, Ada, OK 74820, USA. Email:
    Hypercalcemia is rarely associated with colon cancer. It is related to overexpression of parathyroid hormone-related protein (PTH-rp) in malignant cells of the primary colon tumor and metastases. A 44 year old lady presented for evaluation of severe hypercalcemia (15. Read More

    Small Cell Lung Cancer (SCLC) Presenting as Acute Pancreatitis: The Role of Hypercalcemia.
    World J Oncol 2012 Feb 19;3(1):42-44. Epub 2012 Feb 19.
    Kettering Medical Center Internal Medicine Residency Program - Graduate Medical Education, Kettering, OH, USA.
    A 53-year-old smoker female presented to our hospital with abdominal pain secondary to acute pancreatitis. Severe hypercalcemia was felt to be the precipitating cause of pancreatitis. Her work up showed SCLC with bone marrow metastases as the only site of extra-thoracic metastases. Read More

    A Case of Ovarian Clear Cell Carcinoma Simultaneously Producing Parathyroid Hormone-related Protein and Granulocyte Colony-Stimulating Factor.
    World J Oncol 2010 Jun 19;1(3):138-141. Epub 2010 May 19.
    Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, Hirosaki, Aomori 036-8562, Japan.
    We describe the first report of an ovarian clear cell carcinoma simultaneously producing parathyroid hormone-related protein (PTHrP) and granulocyte colony-stimulating factor (G-CSF). A 64-year-old woman complained of general fatigue, loss of appetite, nausea, vomiting and constipation. The results of blood and biochemistry tests were white blood cell count of 21,060 /ml and calcium of 18. Read More

    Acute Shoulder Monoarthritis in a Patient With Acute Myelomonocytic Leukemia With Novel Translocation t(5;13).
    World J Oncol 2010 Feb 1;1(1):50-51. Epub 2010 Feb 1.
    Kettering Medical Center, Internal Medicine Residency Program, Department of Medical Education, Dayton, OH, USA.
    We present the case of a patient with acute myelomonocytic leukemia with trisomy 8 and novel translocation t(5;13). In addition to acute leukemia she had debilitating left shoulder arthritis due to granulocytic sarcoma formation in the joint space. Her shoulder pain did not improve during induction chemotherapy but she experienced rapid relief of symptoms with use of local radiation. Read More

    ENDOCRINE MANIFESTATIONS OF PRIMARY HYPEROXALURIA.
    Endocr Pract 2017 Nov 16. Epub 2017 Nov 16.
    From: 1Department of Endocrinology, Diabetes, and Metabolism, University of Illinois, Chicago, IL, USA.
    Objective: Primary hyperoxaluria type 1 (PH1) is a rare metabolic disorder of oxalate overproduction. It is associated with urolithiasis and nephrocalcinosis which progress to ESRD and systemic oxalosis. As oxalate deposits in tissues, non-parathyroid hormone (nonPTH) mediated hypercalcemia, oxalate osteopathy, primary hypothyroidism and primary hypogonadism develop. Read More

    Severe Hypercalcemia Related to Silicone Granulomas, as Discovered by FDG-PET.
    Indian J Nucl Med 2017 Oct-Dec;32(4):343-344
    Department of Radiology, Mayo Clinic, Jacksonville, Florida, USA.
    Silicone injected for cosmetic purposes can provoke an inflammatory granulomatous response. In turn, silicone granulomas can lead to hypercalcemia, which is a rare, though potentially life-threatening condition. Hypercalcemia is a nonspecific laboratory finding with many potential etiologies. Read More

    Familial Hyperparathyroidism - Disorders of Growth and Secretion in Hormone-Secretory Tissue.
    Horm Metab Res 2017 Nov 14;49(11):805-815. Epub 2017 Nov 14.
    Hospital das Clinicas, University of São Paulo School of Medicine Sao Paulo, Sao Paulo, Brazil.
    Six syndromes of familial hyperparathyroidism are compared: 1) Familial hypocalciuric hypercalcemia (FHH) expresses primary hyperparathyroidism (PHPT) beginning at birth with lifelong hypercalcemia. There is nonsuppressed PTH secretion from outwardly normal parathyroid glands. It reflects germline heterozygous mutation in CASR, GNA11, or AP2S1. Read More

    Surgery for Primary Hyperparathyroidism with Normal Non-suppressed Parathyroid Hormone can be Both Challenging and Successful.
    World J Surg 2017 Nov 13. Epub 2017 Nov 13.
    Department of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
    Background: Criteria for diagnosing primary hyperparathyroidism (PHPT) include hypercalcemia in the presence of parathyroid hormone (PTH) levels that are either elevated (classic PHPT) or normal but non-suppressed. However, there is no standard definition of what constitutes normal non-suppressed levels, and data are lacking regarding the potential for surgical cure in these patients.

    Methods: A retrospective review of patients undergoing parathyroidectomy for sporadic PHPT between 2012 and 2014 was performed. Read More

    Sporadic Primary Hyperparathyroidism and Stone Disease: a Comprehensive Metabolic Evaluation Before and After Parathyroidectomy.
    BJU Int 2017 Nov 10. Epub 2017 Nov 10.
    Section of Endourology Division of Urology, Hospital das Clínicas, University of Sao Paulo Medical School, Sao Paulo, Brazil.
    Objectives: to characterize the stone risk and the impact of parathyroidectomy on the metabolic profile of patients with primary hyperparathyroidism (PHPT) and urolithiasis.

    Subjects And Methods: We analyzed the prospectively collected charts of patients treated at our stone clinic from Jan/2001-Jan/2016 searching for patients with PHPT and urolithiasis. Imaging evaluation of the kidneys, bones and parathyroid glands were assessed. Read More

    [Primary hyperparathyroidism - new clinical forms of the disease].
    Vnitr Lek 2017 ;63(9):604-608
    Primary hyperparathyroidism (PHPT) has been increasingly diagnosed incidentally in its asymptomatic form owing to calcium screening tests. This form of PHPT represents 80% in developed countries. Although PHPT patients are asym-ptomatic, target organ (bone and kidney) involvement is frequently observed. Read More

    Atypical manifestation of parathyroid carcinoma with late-onset distant metastases.
    Endocrinol Diabetes Metab Case Rep 2017 28;2017. Epub 2017 Oct 28.
    Department of Pathophysiology, National and Kapodistrian University of Athens, Athens, Greece.
    Parathyroid carcinoma is an extremely rare endocrine malignancy that accounts for less than 1% of cases of primary hyperparathyroidism. We report a 44-year-old woman who presented with fatigue and diffuse bone pain. Laboratory findings revealed highly elevated serum calcium and parathyroid hormone (PTH) levels and a 4. Read More

    Familial Hypocalciuric Hypercalcemia as an Atypical Form of Primary Hyperparathyroidism.
    J Bone Miner Res 2017 Nov 8. Epub 2017 Nov 8.
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda Md 20892.
    Introduction Familial hypocalciuric hypercalcemia (FHH) causes lifelong hypercalcemia with features that overlap with typical primary hyperparathyroidism (PHPT). The incompleteness of this overlap has led to divergent nomenclatures for FHH. I compare two nomenclatures. Read More


    Skeletal effects of failed parathyroidectomy.
    Surgery 2017 Nov 3. Epub 2017 Nov 3.
    Section of Endocrine Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA.
    Background: Parathyroidectomy improves bone mineral density and decreases risk for fracture in patients with primary hyperparathyroidism. The aim of this study was to determine skeletal consequences of failed parathyroidectomy.

    Methods: A retrospective, cohort study of patients with biochemically confirmed primary hyperparathyroidism within a vertically integrated health system was performed (1995-2014). Read More

    Long-Term Use of Cinacalcet in Kidney Transplant Recipients With Hypercalcemic Secondary Hyperparathyroidism: A Single-Center Prospective Study.
    Exp Clin Transplant 2017 Oct 31. Epub 2017 Oct 31.
    From the Department of Nephrology and Renal Transplantation, University Hospital of Patras, Patras, Greece.
    Objectives: Persistent secondary hyperparathyroidism is common after successful kidney transplant, with concomitant hypercalcemia and hypophosphatemia potentially leading to reduced graft survival and increased cardiovascular risk. Cinacalcet, a calcimimetic agent that activates the calcium-sensing receptors in parathyroid glands, is a therapeutic option. In this study, we assessed the long-term treatment effects of cinacalcet for a period of up to 5 years in a cohort of kidney transplant recipients. Read More

    Occult Massive Visceral Fat Necrosis Following Therapeutic Hypothermia for Neonatal Encephalopathy.
    Pediatr Dev Pathol 2017 Jan 1:1093526617737881. Epub 2017 Jan 1.
    1 Department of Pathology, 22209 Women and Infants Hospital, Providence, Rhode Island.
    Therapeutic hypothermia (head or whole-body cooling) improves survival and neurodevelopmental outcome in term newborns with moderate-to-severe encephalopathy. Hypothermia treatment is well tolerated; the most common side effect is thrombocytopenia. In about 1% of infants, focal subcutaneous fat necrosis has been reported. Read More

    Antitumoral effects of the alkynylphosphonate analogue of calcitriol EM1 on glioblastoma multiforme cells.
    J Steroid Biochem Mol Biol 2017 Nov 2. Epub 2017 Nov 2.
    Laboratorio de Biología del Cáncer, Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB), Universidad Nacional del Sur (UNS), CONICET, Departamento de Biología, Bioquímica y Farmacia (UNS), Bahía Blanca, Argentina. Electronic address:
    Glioblastoma multiforme (GBM) is the worst and most common brain tumor, characterized by high proliferation and invasion rates. The current standard treatment is mainly based on chemoradiotherapy and this approach has slightly improved patient survival. Thus, novel strategies aimed at prolonging the survival and ensuring a better quality of life are necessary. Read More

    Comprehensive genomic profiling reveals inactivating SMARCA4 mutations and low tumor mutational burden in small cell carcinoma of the ovary, hypercalcemic-type.
    Gynecol Oncol 2017 Dec 6;147(3):626-633. Epub 2017 Nov 6.
    Foundation Medicine Inc., Cambridge, MA, United States. Electronic address:
    Objective: Small cell carcinoma of the ovary, hypercalcemic-type (SCCOHT) is a rare, extremely aggressive neoplasm that usually occurs in young women and is characterized by deleterious germline or somatic SMARCA4 mutations. We performed comprehensive genomic profiling (CGP) to potentially identify additional clinically and pathophysiologically relevant genomic alterations in SCCOHT.

    Methods: CGP assessment of all classes of coding alterations in up to 406 genes commonly altered in cancer and intronic regions for up to 31 genes commonly rearranged in cancer was performed on 18 SCCOHT cases (16 exhibiting classic morphology and 2 cases exhibiting exclusive a large cell variant morphology). Read More

    Early identification and intervention matters: A comprehensive review of current evidence and recommendations for the monitoring of bone health in patients with cancer.
    Cancer Treat Rev 2017 Dec 18;61:23-34. Epub 2017 Oct 18.
    Center for Comprehensive Gynecology, Augustaanlage 7-11, 68165 Mannheim, Germany. Electronic address:
    Bone metastases are common in patients with advanced solid tumors, and many individuals experience debilitating skeletal-related events (SREs; e.g. pathologic fracture, hypercalcemia, radiotherapy or surgery to bone, and spinal cord compression). Read More

    [Multiple myeloma : What has been confirmed in therapy?]
    Internist (Berl) 2017 Nov 2. Epub 2017 Nov 2.
    Medizinische Klinik V, Universitätsklinikum Heidelberg, INF 410, 69120, Heidelberg, Deutschland.
    Multiple myeloma (MM) is a malignancy of terminally differentiated B cells/plasma cells and is primarily located in the bone marrow. Symptomatic multiple myeloma typically presents with osteolyses, anemia, reduced renal function, and/or hypercalcemia. In the case of such MM-related end organ damage, urgent systemic treatment is indicated. Read More

    Acute pancreatitis as an initial manifestation of parathyroid carcinoma: A case report and literature review.
    Medicine (Baltimore) 2017 Nov;96(44):e8420
    Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Rationale: Parathyroid carcinoma is a rare endocrine malignancy. Acute pancreatitis as an initial manifestation of parathyroid carcinoma has been rarely reported.

    Patient Concerns: A 22-year-old woman was admitted to emergency room with a sudden attack of severe epigastric pain. Read More

    Paratharmone related protein (peptide): A novel prognostic, diagnostic and therapeutic marker in Head & Neck cancer.
    J Stomatol Oral Maxillofac Surg 2017 Nov 3. Epub 2017 Nov 3.
    Department of oral medicine and radiology, Sri Hasanamba dental college and hospital, Vidyanagar, 573202 Hassan, Karnataka, India.
    Parathyroid hormone-related protein (PTHrP) is a promising modality of assessment of different critical features of cancer. It is a protein member of parathyroid hormone family, secreted by certain physiologic cells and by malignant tumors in an increased amount. Recent studies have confirmed that PTHrP massively contributes to malignant behaviour of oral cancers-cell proliferation, migration and invasiveness. Read More

    Genetic Diseases of Vitamin D Metabolizing Enzymes.
    Endocrinol Metab Clin North Am 2017 Dec 5;46(4):1095-1117. Epub 2017 Oct 5.
    Department of General Pediatrics, University Children's Hospital, Waldeyerstr. 22, D-48149 Muenster, Germany.
    Vitamin D metabolism involves 3 highly specific cytochrome P450 (CYP) enzymes (25-hydroxylase, 1α-hydroxylase, and 24-hydroxylase) involved in the activation of vitamin D3 to the hormonal form, 1,25-(OH)2D3, and the inactivation of 1,25-(OH)2D3 to biliary excretory products. Mutations of the activating enzymes CYP2R1 and CYP27B1 cause lack of normal 1,25-(OH)2D3 synthesis and result in rickets whereas mutations of the inactivating enzyme CYP24A1 cause build-up of excess 1,25-(OH)2D3 and result in hypercalcemia, nephrolithiasis, and nephrocalcinosis. This article reviews the literature for 3 clinical conditions. Read More

    Oncologic Metabolic Emergencies.
    Hematol Oncol Clin North Am 2017 Dec;31(6):941-957
    Department of Emergency Medicine, Keck School of Medicine of the University of Southern California, 1200 North State Street, Room 1011, Los Angeles, CA 90033, USA.
    Cancer and its therapies may lead to several metabolic emergencies that emergency providers (EPs) should be well-versed in identifying and managing. With prompt recognition and treatment initiation in the emergency department, lives can be saved and quality of life maintained. Most oncologic metabolic emergencies occur in advanced cancer states, but some follow initiation of treatment or may be the presenting syndrome that leads to the cancer diagnosis. Read More

    Vitamin-D Toxicity And Other Non-Malignant Causes Of Hypercalcemia: A Retrospective Study At A Tertiary Care Hospital In Pakistan.
    J Ayub Med Coll Abbottabad 2017 Jul-Sep;29(3):436-440
    Aga Khan University Hospital Karachi, Pakistan.
    Background: Hypercalcemia is a common clinical problem; primary hyperparathyroidism and malignancy is commonest causes of hypercalcemia. Aetiology of hypercalcemia are changing, causes that were diseases of the past like Vitamin-D toxicity and milk alkali syndrome are observed more often. Vitamin-D deficiency is an important problem and overzealous replacement of Vitamin-D has been observed, suspected to cause toxicity. Read More

    Cytological challenges in the diagnosis of intrathyroidal parathyroid carcinoma: A case report and review of literature.
    Diagn Cytopathol 2017 Oct 27. Epub 2017 Oct 27.
    Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
    Parathyroid carcinoma is an uncommon malignancy and the probability of an intrathyroidal location is low. Fine needle aspirations (FNA) of these presumably "thyroid nodules" can lead to misinterpretation because of the similarities in cytological features of parathyroid and thyroid lesions. Despite limitations, USG guided FNA cytology remains the first line of investigation. Read More

    Low incidence of hypercalcemia following combined calcipotriol hydrate/betamethasone dipropionate ointment treatment in Japanese patients with severe psoriasis vulgaris.
    J Dermatolog Treat 2017 Oct 27:1-16. Epub 2017 Oct 27.
    a Department of Geriatric and Environmental Dermatology , Nagoya City University Graduate School of Medical Sciences , Nagoya , Japan.
    Purpose: Topical active vitamin D3 application alone or in combination with topical steroid application is widely used to treat psoriasis. In Japan, combined calcipotriol hydrate/betamethasone dipropionate ointment has been used for patients with psoriasis vulgaris since September 2014. Current evidence regarding the incidence of hypercalcemia due to the use of this combination product, however, is insufficient. Read More

    Bone Histo-Morphology in Chronic Kidney Disease Mineral Bone Disorder.
    Indian J Hematol Blood Transfus 2017 Dec 28;33(4):603-610. Epub 2016 Nov 28.
    Department of Pathology, Maulana Azad Medical College, 64 Kala Vihar Apt, Mayur Vihar Phase 1 extn, New Delhi, 91 India.
    Chronic Kidney Disease-Mineral Bone Disorder(CKD-MBD) is a systemic disorder of the mineral and bone metabolism seen in patients with Chronic Kidney Disease(CKD). It is manifested by either one or a combination of the following: (a) Abnormalities of calcium, phosphorus, PTH, or vitamin D metabolism. (b) Abnormalities in bone turnover, mineralization, volume, linear growth, or strength. Read More

    [Update on recent progress in vitamin D research. Vitamin D receptor and the nuclear receptor superfamily.]
    Clin Calcium 2017 ;27(11):1533-1541
    Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan.
    The vitamin D receptor(VDR)is a ligand-dependent transcription factor of the nuclear receptor superfamily. VDR belongs to the NR1I subfamily along with other nuclear receptors involved in xenobiotic metabolism, such as pregnane X receptor. The oxysterol receptors liver X receptors α/β and the bile acid receptor farnesoid X receptor belong to the NR1H subfamily, which are closely related to the NR1I subfamily. Read More

    Hypercalcemia in children: three cases report with unusual clinical presentations.
    J Bras Nefrol 2017 Apr-Jun;39(2):213-216
    Universidade Estadual de Campinas.
    Hypercalcemia is a rare condition in childhood; the most common causes are primary hyperparathyroidism, malignancy, prolonged immobilisation, thyrotoxicosis, thiazide diuretic, supplements containing calcium, milk-alkali syndrome, vitamin D intoxication, infections and idiopathic. We present three cases of severe hypercalcemia of unusual causes in children. The first patient had high fever, poor general condition, weight loss and myalgia. Read More

    Does combination of paricalcitol with cinacalcet in secondary hyperparathyroidism in hemodialysis treatment make sense?
    Pol Arch Intern Med 2017 Oct 25. Epub 2017 Oct 25.
    INTRODUCTION    Secondary hyperparathyroidism (SHPT) is a common hormonal disorder associated with  chronic kidney disease (CKD). SHPT treatment should lead to reduction of parathormon concentration by calcimimetics or active vitamin D administration and calcium-phosphate metabolism stabilization. In the event of failure of conservative treatment complete or partial parathyroid resection should be considered. Read More

    Giant mediastinal parathyroid adenoma presenting as bilateral brown tumour of mandible: a rare presentation of primary hyperparathyroidism.
    BMJ Case Rep 2017 Oct 23;2017. Epub 2017 Oct 23.
    Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    Hyperparathyroidism (HPT) is becoming increasingly common endocrinopathy in clinical practice. Nowadays, it is mostly diagnosed in subclinical or early clinical stage. Bony involvement in HPT has seen significant fall in incidence. Read More

    Animal Models of Cancer-Associated Hypercalcemia.
    Vet Sci 2017 Apr 13;4(2). Epub 2017 Apr 13.
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
    Cancer-associated hypercalcemia (CAH) is a frequently-occurring paraneoplastic syndrome that contributes to substantial patient morbidity and occurs in both humans and animals. Patients with CAH are often characterized by markedly elevated serum calcium concentrations that result in a range of clinical symptoms involving the nervous, gastrointestinal and urinary systems. CAH is caused by two principle mechanisms; humorally-mediated and/or through local osteolytic bone metastasis resulting in excessive calcium release from resorbed bone. Read More

    Parathyroid hormone related protein induced hypercalcemia of pregnancy successfully reversed by a dopamine agonist.
    J Clin Endocrinol Metab 2017 Oct 18. Epub 2017 Oct 18.
    Center for Bone Quality: Department of Internal Medicine: division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.
    Context: Parathyroid hormone related protein (PTH-rP) induced hypercalcemia or pseudophyperparathyroidism during pregnancy is a condition that can result in serious foetal and maternal complications. Among others, breast tissue might be the cause of this PTH-rP production, in which case medical treatment is possible, as we describe in this case.

    Setting: A 32-year old woman presented in the15th week of pregnancy with massive enlargement of breasts and abdominal pain due to severe hypercalcemia, hypercalciuria and suppressed PTH. Read More

    Chronic Lymphocytic Leukemia: A Rare Cause of Pathological Fracture of the Femur.
    J Investig Med High Impact Case Rep 2017 Oct-Dec;5(4):2324709617735135. Epub 2017 Oct 3.
    Maimonides Medical Center, Brooklyn, NY, USA.
    The incidence rate of chronic lymphocytic leukemia (CLL) in the United States is approximately 0.005%; men are at slightly higher risk than women. Bony involvement or pathological fracture rarely occurs in CLL, and it may be the initial presentation. Read More

    HTLV-1 viral oncogene HBZ induces osteolytic bone disease in transgenic mice.
    Oncotarget 2017 Sep 27;8(41):69250-69263. Epub 2017 Aug 27.
    Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, USA.
    Adult T-cell leukemia/lymphoma (ATL) is an aggressive T cell malignancy that occurs in HTLV-1 infected patients. Most ATL patients develop osteolytic lesions and hypercalcemia of malignancy, causing severe skeletal related complications and reduced overall survival. The HTLV-1 virus encodes 2 viral oncogenes, Tax and HBZ. Read More

    Abaloparatide Comparator Trial In Vertebral Endpoints (ACTIVE) confirms that abaloparatide is a valuable addition to the armamentarium against osteoporosis.
    Expert Opin Pharmacother 2017 Nov 14:1-3. Epub 2017 Nov 14.
    a Public Health, Epidemiology and Health Economics , University of Liège , Liège , Belgium.
    The recently published Abaloparatide Comparator Trial in Vertebral Endpoints (ACTIVE) assessed the efficacy and safety of abaloparatide (80 µg daily subcutaneous) (ABL) vs placebo during 18 months, in postmenopausal osteoporosis. Teriparatide (20 µg daily subcutaneous) (TPD) was used as an open label active comparator. The results of the study suggest that ABL increases bone mineral density more than TPD and reduces major osteoporotic fractures to a greater extent than TPD with a more rapid onset of action. Read More

    The use of cinacalcet hinders the diagnosis of parathyroid carcinoma in a chronic dialysis patient: a case report.
    BMC Nephrol 2017 Oct 18;18(1):315. Epub 2017 Oct 18.
    Department of Nephrology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo, Kyoto, Japan.
    Background: Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving chronic dialysis therapy. Although cinacalcet can control parathyroid function and bone turnover, preventing ectopic calcification remains challenging. Cinacalcet can also suppress PTH secretion due to parathyroid carcinoma in the same way as it does for parathyroid hyperplasia in the uremic condition. Read More

    Cinacalcet corrects hypercalcemia in mice with an inactivating Gα11 mutation.
    JCI Insight 2017 Oct 19;2(20). Epub 2017 Oct 19.
    Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
    Loss-of-function mutations of GNA11, which encodes G-protein subunit α11 (Gα11), a signaling partner for the calcium-sensing receptor (CaSR), result in familial hypocalciuric hypercalcemia type 2 (FHH2). FHH2 is characterized by hypercalcemia, inappropriately normal or raised parathyroid hormone (PTH) concentrations, and normal or low urinary calcium excretion. A mouse model for FHH2 that would facilitate investigations of the in vivo role of Gα11 and the evaluation of calcimimetic drugs, which are CaSR allosteric activators, is not available. Read More

    Primary renal lymphoma: an unusual finding following radical nephrectomy.
    Clin Nephrol Case Stud 2017 31;5:1-4. Epub 2017 Jan 31.
    Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
    Secondary kidney involvement by disseminated non-Hodgkin's lymphoma (NHL) is quite common and is estimated to approach 30 - 60% in NHL patients. However, primary renal lymphoma is exceedingly rare and estimated to make up less than 1% of all kidney masses. We report a case of primary renal NHL presenting with profound hypercalcemia and renal failure recalcitrant to medical management, ultimately treated with urgent radical nephrectomy. Read More

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