19,524 results match your criteria Milk-Alkali Syndrome


Antacid-induced acute hypercalcemia: An increasingly common and potentially dangerous occurrence.

SAGE Open Med Case Rep 2020 19;8:2050313X20921335. Epub 2020 May 19.

Department of Endocrinology, Richmond University Medical Center, Staten Island, NY, USA.

Hypercalcemia is frequently encountered in both hospital wards and the primary care setting; 90% of cases can be attributed to primary hyperparathyroidism and malignancy. However, a minority are caused by medications, of which calcium supplements have been an increasingly common etiology. We are presenting a case of hypercalcemia resulted after acute oral intake of a moderate amount of antacids (calcium tablets) and normalized after supplement withdrawal. Read More

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http://dx.doi.org/10.1177/2050313X20921335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238301PMC

Hypercalcemia, hyperuricemia, and kidney dysfunction in a 35-month-old boy: Questions.

Pediatr Nephrol 2020 Jun 2. Epub 2020 Jun 2.

Department of Nephrology and Immunology, Children's Hospital of Soochow University, 303 Jingde Road, Suzhou, Jiangsu Province, The People's Republic of China.

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http://dx.doi.org/10.1007/s00467-020-04601-8DOI Listing

Hypercalcemia, hyperuricemia, and kidney dysfunction in a 35-month-old boy: Answers.

Pediatr Nephrol 2020 Jun 2. Epub 2020 Jun 2.

Department of Nephrology and Immunology, Children's Hospital of Soochow University, 303 Jingde Road, Suzhou, Jiangsu Province, The People's Republic of China.

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http://dx.doi.org/10.1007/s00467-020-04603-6DOI Listing

Teriparatide (rPTH1-34) enhances bone allograft integration in a clinically relevant pig model of segmental mandibulectomy.

J Tissue Eng Regen Med 2020 Jun 1. Epub 2020 Jun 1.

Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Massive craniofacial bone loss poses a clinical challenge to maxillofacial surgeons. Structural bone allografts are readily available at tissue banks, but are rarely used due to a high failure rate. Previous studies showed that intermittent administration of recombinant parathyroid hormone (rPTH) enhanced integration of allografts in a murine model of calvarial bone defect. Read More

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http://dx.doi.org/10.1002/term.3075DOI Listing

Sarcoidosis in the United States Military Health System.

Sarcoidosis Vasc Diffuse Lung Dis 2018 28;35(3):261-267. Epub 2018 Apr 28.

Walter Reed National Military Medical Center, Bethesda, MD, Department of Pulmonology.

Sarcoidosis is an inflammatory disorder of unclear etiology with historical significance in the U.S. Department of Defense (DoD). Read More

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http://dx.doi.org/10.36141/svdld.v35i3.6949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170159PMC

Repository corticotropin injection (H.P. Acthar gel) for the treatment of sarcoidosis-induced hypercalciuria and vitamin D dysregulation: a pilot, open label study.

Sarcoidosis Vasc Diffuse Lung Dis 2018 28;35(3):192-197. Epub 2018 Apr 28.

Department of Epidemiology and Biostatistics, School of Public Health, State University of New York at Albany, Rensselaer, NY 12144.

Vitamin D dysregulation may occur in sarcoidosis patients and result in hypercalciuria, hypercalcemia, nephrolithiasis, and renal impairment. We performed an open label pilot study of highly purified (H.P. Read More

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http://dx.doi.org/10.36141/svdld.v35i3.6917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170160PMC

Vitamin D status in sarcoidosis: a cross-sectional study.

Sarcoidosis Vasc Diffuse Lung Dis 2018 28;35(2):154-159. Epub 2018 Apr 28.

Health Services Research and Implementation Science, Kaiser Permanente Southern California.

Hypercalcemia, a common feature in sarcoidosis, is due to the excessive production of active Vitamin D metabolite, 1,25(OH)D. Levels of 25(OH) Vitamin D however may not be appropriate. To assess Vitamin D status and its clinical associations in sarcoidosis patients compared to a general respiratory diseases out-patient clinic population, serving as controls. Read More

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http://dx.doi.org/10.36141/svdld.v35i2.6199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170088PMC

Clinical characteristics of sarcoidosis patients in the United States versus China.

Sarcoidosis Vasc Diffuse Lung Dis 2017 9;34(3):209-216. Epub 2020 Mar 9.

Department of Internal Medicine, University of Cincinnati Medical Center, 1001 Holmes, Eden Ave, Cincinnati, OH 45267, USA.

To characterize and compare the disease manifestations between patients with sarcoidosis in China versus the United States using the World Association of Sarcoidosis and Other Granulomatous disease (WASOG) instrument. Clinical data and disease manifestations were reviewed from sarcoidosis patients from the Shanghai Pulmonary Hospital (China) and University of Cincinnati Medical Center (US). 481 Chinese patients and 522 US patients with sarcoidosis were studied. Read More

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http://dx.doi.org/10.36141/svdld.v34i3.5727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170095PMC

Sarcoidosis and adrenal angiomyolipoma - A rare tumor and a rarer coincidence.

Sarcoidosis Vasc Diffuse Lung Dis 2017 28;34(1):81-84. Epub 2017 Apr 28.

Department of Urology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.

Angiomyolipoma is a benign mesenchymal tumor occurring in about 0.3 % of the general population. Angiomyolipoma of the adrenal gland is a rare entity, and only 5 cases have been reported so far in English literature. Read More

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http://dx.doi.org/10.36141/svdld.v34i1.4506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170107PMC

Risk factors for hypercalcemia in patients with tuberculosis.

Int J Mycobacteriol 2020 Jan-Mar;9(1):7-11

Department of Internal Medicine, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Tuberculosis (TB) is prevalent worldwide and causes significant morbidity and mortality. TB is known to cause hypercalcemia. We aimed to assess the prevalence and risk factors for developing hypercalcemia among patients with TB. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_211_19DOI Listing

A comparative analysis of the efficacy and safety of paricalcitol versus other vitamin D receptor activators in patients undergoing hemodialysis: A systematic review and meta-analysis of 15 randomized controlled trials.

PLoS One 2020 29;15(5):e0233705. Epub 2020 May 29.

Hemodialysis Room, The Fourth Central Hospital of Baoding City, Baoding, Hebei, China.

Paricalcitol, a new vitamin D receptor activator (VDRA), is reported to be more effective than other VDRAs in reducing calcium and phosphorus levels in patients undergoing hemodialysis. However, the efficacy and safety of paricalcitol remain controversial. This analysis compares paricalcitol with other VDRAs in patients undergoing hemodialysis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233705PLOS

A case report of successful identification of ectopic parathyroid adenomas with a sequence of selective parathyroid venous sampling and 4D-computed tomography in a patient with recurrent hyperparathyroidism.

Int J Surg Case Rep 2020 May 7;71:183-186. Epub 2020 May 7.

Endocrinology and Metabolism Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Thailand. Electronic address:

Introduction: Recurrent hyperparathyroidism is difficult to manage due to the difficulty in finding the missing adenoma. Herein we present a case of recurrent hyperparathyroidism from ectopic adenomas which basic investigations failed to locate but were finally localized by a 4DCT following selective venous sampling (SVS) of parathyroid hormone (PTH).

Presentation Of Case: A young female presented with recurrent hyperparathyroidism. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256430PMC

Prognostic value of pretreatment neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in multiple myeloma patients treated with thalidomide-based regimen.

Ann Hematol 2020 May 26. Epub 2020 May 26.

Chair and Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-081, Lublin, Poland.

Neutrophils to lymphocytes ratio (NLR) and platelets to lymphocytes ratio (PLR) are considered as laboratory markers of inflammation. They can be potentially useful in predicting the course of multiple neoplasms including selected hematological cancers. The aim of the study was to assess the value of NLR and PLR in predicting the effects of therapy and prognosis in multiple myeloma patients treated with thalidomide-based regimen. Read More

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http://dx.doi.org/10.1007/s00277-020-04092-5DOI Listing

Pediatric Case of Successful Point-of-Care Ultrasound-Guided Nasogastric Tube Placement.

J Emerg Med 2020 May 23. Epub 2020 May 23.

Division of Pediatric Emergency Medicine, Department of Pediatric Emergency and Critical Care Medicine, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.

Background: Nasogastric tube (NGT) placement is commonly performed in pediatric emergency care and is classically confirmed by any one of several methods, among which auscultation or aspiration and radiography comprise the currently recognized as the reference standard. Point-of-care ultrasound (POCUS) is used to confirm NGT insertion, especially in adults or prehospital patients, but reports of its use in the pediatric emergency department (ED) are still scarce. We report a case of successful POCUS-guided NGT placement in a pediatric ED. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.04.029DOI Listing

A 39 year-old woman with milk-alkali syndrome complicated by posterior reversible encephalopathy syndrome.

Bone Rep 2020 Jun 4;12:100278. Epub 2020 May 4.

Grand Strand Medical Center, 809 82nd Pkwy, Myrtle Beach, SC 29572, United States.

Milk-alkali syndrome (MAS) is characterized by the triad of hypercalcemia, metabolic alkalosis, and acute kidney injury. Once thought to be a rare condition, there has been a resurgence of cases due to the consumption of calcium-containing supplements for osteoporosis prevention and dyspepsia in the general population. We describe the case of a female who presented with acute encephalopathy, hypercalcemia, and new-onset seizure. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235952PMC

A rare case of parathyroid crisis with respiratory failure successfully treated using extracorporeal membrane oxygenation.

Respir Med Case Rep 2020 11;30:101088. Epub 2020 May 11.

Department of Respiratory Medicine, Hyogo Prefectural Amagasaki General Medical Center, 2-17-77 Higashinaniwa-cho, Amagasaki, Hyogo, 660-8550, Japan.

Parathyroid crisis, which might occur during the natural history of primary hyperparathyroidism, presents fatal hypercalcemia. Although hyperparathyroidism is known to cause metastatic pulmonary calcification, parathyroid crisis with respiratory failure is rarely reported. Here, we present a case of parathyroid crisis with respiratory failure due to parathyroid adenoma. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236054PMC

Association of gender with serum potassium, sodium and calcium disorders after hypertensive intracerebral hemorrhage.

World Neurosurg 2020 May 23. Epub 2020 May 23.

Department of Neurosurgery, Heze Municipal Hospital, Heze 274031, China. Electronic address:

Objective: To determine the association of gender with serum potassium, sodium and calcium disorders in patients with hypertensive intracerebral hemorrhage, and meanwhile investigate other risk factors.

Methods: 516 patients with hypertensive intracerebral hemorrhage were retrospectively enrolled. The clinical characteristics were collected. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.137DOI Listing

Long-term results of a randomized study comparing parathyroidectomy with cinacalcet for treating tertiary hyperparathyroidism.

Clin Transplant 2020 May 21:e13988. Epub 2020 May 21.

Nephrology Department, Hospital Universitari de Bellvitge, University of Barcelona, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

Tertiary hyperparathyroidism is a common cause of hypercalcemia after kidney transplantation (KT) and has been associated with renal dysfunction, bone mineral density loss, and increased risk of fracture and cardiovascular events. In a previous 12-month clinical trial, we demonstrated that subtotal parathyroidectomy was more effective than cinacalcet for controlling hypercalcemia. In the current study, we retrospectively evaluate whether this effect is maintained after 5 years of follow-up. Read More

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http://dx.doi.org/10.1111/ctr.13988DOI Listing

A Systematic Review and Meta-Analysis about the Effect of Bisphosphonates on the Risk of Skeletal-Related Event in Men with Prostate Cancer.

Anticancer Agents Med Chem 2020 May 21. Epub 2020 May 21.

Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province. China.

Background: Although the adjuvant therapy of bisphosphonates in prostate cancer is effective in improving bone mineral density, it's still uncertain whether bisphosphonates could decrease the risk of Skeletal-Related Event (SRE) in patients with prostate cancer. We reviewed and analyzed the effect of different types of bisphosphonates on the risk of SRE, defifined as pathological fracture, spinal cord compression, radiation therapy to bone, surgery to bone, hypercalcemia, bone pain, or death as a result of prostate cancer.

Methods: A systemic literature search was conducted in PubMed and related bibliographies. Read More

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http://dx.doi.org/10.2174/1871520620666200521114815DOI Listing

Over-the-Counter Drug Causing Acute Pancreatitis.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620922724

Geisinger Health System, Danville, PA, USA.

Acute pancreatitis is caused by alcohol, gall stone disease, drugs, trauma, infections, and metabolic causes such as hypercalcemia and hyperlipidemia. Hypercalcemia-induced acute pancreatitis has been well documented but only rarely occurs due to over-the-counter calcium carbonate. In this article, we present a case of over-the-counter calcium carbonate-induced acute pancreatitis. Read More

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http://dx.doi.org/10.1177/2324709620922724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243389PMC

Different Potent Glucocorticoids, Different Routes of Exposure but The Same Result: Iatrogenic Cushing's syndrome and Adrenal Insufficiency.

Authors:
Ayla Güven

J Clin Res Pediatr Endocrinol 2020 May 20. Epub 2020 May 20.

Health Science University Medical Faculty, Zeynep Kamil Women and Children Hospital, Pediatric Endocrinology Clinic.

Objectives: Potent glucocorticoids (GC) cause iatrogenic Cushing Syndrome (ICS) due to suppression of hypothalamo-hypophyseal-adrenal (HPA) axis and later even adrenal insufficiency (AI). The aim of this study is to review the clinical and laboratory findings of patients with ICS and to demonstrate other serious side effects.

Methods: The possibility of AI was investigated by low-dose ACTH test. Read More

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http://dx.doi.org/10.4274/jcrpe.galenos.2020.2019.0220DOI Listing

Genetic testing for hereditary hyperparathyroidism and familial hypocalciuric hypercalcaemia in a large UK cohort.

Clin Endocrinol (Oxf) 2020 May 19. Epub 2020 May 19.

Department of Endocrinology, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK.

Primary hyperparathyroidism (PHPTH) is a common endocrine disorder and an estimated 10% of cases are hereditary, related to syndromes including; multiple endocrine neoplasia (MEN) type 1, MEN type 4, MEN2A and hereditary hyperparathyroidism - jaw tumour syndrome. Establishing the underlying genetic cause for PHPTH allows for personalised and cost-effective management. Familial hypocalcuric hypercalcemia (FHH) is a benign disorder of hypercalcaemia associated with an inappropriately low urinary calcium excretion which is quantified by the calcium creatinine clearance ratio (CCCR). Read More

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http://dx.doi.org/10.1111/cen.14254DOI Listing

Biclonal myeloma in renal failure.

Cent Eur J Immunol 2020 ;45(1):122-124

University Hospital Alexandrovska, Sofia, Bulgaria.

Multiple myeloma is a clonal proliferation of the plasma cell line that accounts for approximately 10% of all hematological malignancies. It is characterized by abnormal growth of plasma cells producing monoclonal immunoglobulin or light chain (paraprotein), with subsequent development of osteolytic bone lesions, anemia, hypercalcemia, and renal failure. In 3-6% of myeloma patients, more than one monoclonal protein (usually two) is discovered, with different heavy or light chain or both. Read More

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http://dx.doi.org/10.5114/ceji.2020.94714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226549PMC
January 2020

Acute Kidney Failure: When Multiple Myeloma Doesn´t Give Additional Clues.

Cureus 2020 Apr 14;12(4):e7664. Epub 2020 Apr 14.

Internal Medicine, Hospital Senhora Da Oliveira, Guimarães, PRT.

Multiple myeloma (MM) is characterized by a proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein. This disease commonly presents with hypercalcemia, kidney failure, anemia, and bone lesions. Acute kidney failure (AKF) as an initial presentation of MM has rarely been reported. Read More

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http://dx.doi.org/10.7759/cureus.7664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224584PMC

Milk-alkali syndrome: a 'quick ease' or a 'long-lasting problem'.

Endocrinol Diabetes Metab Case Rep 2020 May 13;2020. Epub 2020 May 13.

Department of Endocrinology, Nepean Blue Mountains Local Health District, Kingswood, New South Wales, Australia.

Summary: We report the case of a 65-year-old female who presented with symptomatic hypercalcaemia (corrected calcium of 4.57 mmol/L) with confusion, myalgias and abdominal discomfort. She had a concomitant metabolic alkalosis (pH 7. Read More

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http://dx.doi.org/10.1530/EDM-20-0028DOI Listing

First ever case report of co-occurrence of hobnail variant of papillary thyroid carcinoma and intrathyroid parathyroid adenoma in the same thyroid lobe.

Int J Surg Case Rep 2020 May 5;70:40-52. Epub 2020 May 5.

Department of General Surgery, Hamad General Hospital, Doha, Qatar.

Introduction: The hobnail variant of papillary thyroid cancer (PTC) is rare. Intrathyroid parathyroid adenoma (ITPA) is also rare. Co-ocurrence of PTC and ITPA in the same thyroid lobe is extremely rare. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218145PMC

Hypercalcemia and Disseminated Osteolytic Lesions With Normal Blood Counts and Absence of Circulating Blasts: A Rare Presentation of Childhood B-Lymphoblastic Leukemia.

J Pediatr Hematol Oncol 2020 May 12. Epub 2020 May 12.

Division of Pediatric Hematology Oncology.

Hypercalcemia and disseminated osteolytic bone lesions are a rare presentation of pediatric acute lymphoblastic leukemia (ALL). The authors report a 3-year-old boy who presented with hypercalcemia and diffuse osteolytic lesions involving axial and appendicular bones. He had normal complete blood count and the absence of blasts in peripheral smear; however, bone marrow aspirate and trephine were consistent with B-cell ALL. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001822DOI Listing

Coronavirus Disease-19 (COVID-19) associated with severe acute pancreatitis: Case report on three family members.

Pancreatology 2020 May 5. Epub 2020 May 5.

Pancreatitis Centre East, Gastrounit, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark.

Background/objectives: Abdominal pain is one of the known symptoms associated with coronavirus disease 2019. Little is known about the development of acute pancreatitis as a complication of severe acute respiratory syndrome coronavirus 2 infection. This case report describes the presentation of acute pancreatitis in two of three family members with severe COVID-19 infection. Read More

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http://dx.doi.org/10.1016/j.pan.2020.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199002PMC

Familial Hypocalciuric Hypercalcemia Type 1 and Autosomal-Dominant Hypocalcemia Type 1: Prevalence in a Large Healthcare Population.

Am J Hum Genet 2020 Apr 29. Epub 2020 Apr 29.

Regeneron Genetics Center, Tarrytown, NY 10591, USA.

The calcium-sensing receptor (CaSR) regulates serum calcium concentrations. CASR loss- or gain-of-function mutations cause familial hypocalciuric hypercalcemia type 1 (FHH1) or autosomal-dominant hypocalcemia type 1 (ADH1), respectively, but the population prevalence of FHH1 or ADH1 is unknown. Rare CASR variants were identified in whole-exome sequences from 51,289 de-identified individuals in the DiscovEHR cohort derived from a single US healthcare system. Read More

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http://dx.doi.org/10.1016/j.ajhg.2020.04.006DOI Listing

Premature epiphyseal growth plate arrest after isotretinoin therapy for high-risk neuroblastoma: A case series and review of the literature.

Pediatr Blood Cancer 2020 May 9:e28236. Epub 2020 May 9.

Children's Hospital Los Angeles, University of Southern California, Los Angeles, California.

Background: Vitamin A-derived retinoids have been reported to cause skeletal abnormalities ranging from hypercalcemia to premature epiphyseal closure. Isotretinoin is a retinoid used as standard therapy for high-risk neuroblastoma and has been reported to cause premature epiphyseal growth plate arrest.

Procedure: We identified patients from the Children's Hospital Los Angeles (CHLA) database with high-risk neuroblastoma diagnosed from 1991 to 2018 who experienced premature epiphyseal growth plate arrest and compared their characteristics to other patients with high-risk neuroblastoma. Read More

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http://dx.doi.org/10.1002/pbc.28236DOI Listing

The effect of successful parathyroid surgery on left ventricle function in patients with primary hyperparathyroidism evaluated with strain echocardiography.

Echocardiography 2020 May 7;37(5):670-677. Epub 2020 May 7.

General Surgery Clinic, Ataturk Training and Research Hospital, Katip Celebi University, Izmir, Turkey.

Background: Hyperparathyroidism (PHP) is the most common cause of hypercalcemia in outpatients. It is characterized by many cardiac complications including chronic cardiac arrhythmia, hypertrophy, and diastolic insufficiency. However, there are insufficient data about the cardiac systolic function in PHP. Read More

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http://dx.doi.org/10.1111/echo.14660DOI Listing

ADRENAL INCIDENTALOMA, BREAST CANCER AND UNRECOGNIZED MULTIPLE ENDOCRINE NEOPLASIA TYPE 1.

Authors:
S H Kim J H Park

Acta Endocrinol (Buchar) 2019 Oct-Dec;15(4):513-517

Jeonbuk National University Medical School - Department of Internal Medicine, Jeonju, Republic of Korea.

Background: The incidence of adrenal incidentaloma has been increasing proportional to the use of radiologic examination. Multiple endocrine neoplasia1 (MEN1) syndrome may present with various tumors. The present study reports a case of adrenal incidentaloma with unrecognised MEN1 syndrome associated with breast cancer. Read More

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http://dx.doi.org/10.4183/aeb.2019.513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200108PMC

Monoclonal Gammopathy of Undetermined Significance: Indications for Prediagnostic Testing, Subsequent Diagnoses, and Follow-up Practice at Mayo Clinic.

Mayo Clin Proc 2020 May;95(5):944-954

Division of Hematology, Mayo Clinic, Rochester, MN; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN. Electronic address:

Objectives: To determine the indications for prediagnostic testing, subsequent diagnoses found, and follow-up practices in patients who were incidentally diagnosed with monoclonal gammopathy of undetermined significance (MGUS).

Patients And Methods: From our prospective MGUS database, we identified 329 patients residing in southeastern Minnesota who were diagnosed from January 1, 2011, through December 31, 2014, and followed up at Mayo Clinic.

Results: Most test orders came from nonhematologists (n=310, 94. Read More

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http://dx.doi.org/10.1016/j.mayocp.2019.12.033DOI Listing
May 2020
6.262 Impact Factor

Risk Factors for Posttransplant Erythrocytosis: Parathyroid Hormone Paradox?

Exp Clin Transplant 2020 Apr 29. Epub 2020 Apr 29.

From the Department of Nephrology, Gazi University, Ankara, Turkey.

Objectives: Posttransplant erythrocytosis affects 8% to 26% of kidney transplant recipients. In this study, our aim was to define associations among hypercalcemia, persistent hyperparathyroidism, and posttransplant erythrocytosis. We also investigated the effects of biologic sex, age, and dialysis modality before transplant on posttransplant erythrocytosis development. Read More

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http://dx.doi.org/10.6002/ect.2019.0287DOI Listing
April 2020
0.798 Impact Factor

The use of cinacalcet after pediatric renal transplantation: an international CERTAIN Registry analysis.

Pediatr Nephrol 2020 May 4. Epub 2020 May 4.

Reference Center for Rare Renal Disorders, Reference Center for Rare Disorders of Calcium and Phosphate Metabolism, Department of Pediatric Nephrology, Rheumatology and Dermatology, Femme Mère Enfant Hospital, Bron Cedex, France.

Background: Secondary hyperparathyroidism (SHPT) may persist after renal transplantation (RTx), inducing hypophosphatemia and hypercalcemia that precludes the use of vitamin D analogs. The calcimimetic cinacalcet improved plasma calcium and parathyroid hormone (PTH) levels in randomized controlled trials in adults after RTx, but pediatric data are scarce.

Methods: In this retrospective study, we analyzed 20 pediatric patients from the Cooperative European Paediatric Renal TransplAnt Initiative (CERTAIN) Registry who received cinacalcet after RTx. Read More

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http://dx.doi.org/10.1007/s00467-020-04558-8DOI Listing

Noncalcemic Vitamin D Hydroxyderivatives Inhibit Human Oral Squamous Cell Carcinoma and Down-regulate Hedgehog and WNT/β-Catenin Pathways.

Anticancer Res 2020 May;40(5):2467-2474

Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, U.S.A.

Background/aim: The hormonally-active form of vitamin D, 1,25(OH)D, demonstrated activity against oral squamous cell carcinoma (OSCC). Cytochrome P450scc (CYP11A1)-derived vitamin D hydroxyderivatives, such as 20(OH)D and 1,20(OH)D, have overlapping beneficial effects with 1,25(OH)D without causing hypercalcemia. This study sought to determine (i) whether 20(OH)D and 1,20(OH)D exhibit antitumor effects against OSCC comparable to those of 1,25(OH)D and (ii) whether these effects may stem from down-regulation of sonic hedgehog (SHH) or WNT/β-catenin signaling pathways. Read More

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http://dx.doi.org/10.21873/anticanres.14216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241289PMC

Diagnosis and long-term management of post-traumatic seizures in a white-crowned pionus ().

J Am Vet Med Assoc 2020 May;256(10):1145-1152

Case Description: A 13-year-old female white-crowned pionus () was examined because of seizures 22 months after it was treated for a traumatic brain injury (TBI) characterized by vision loss, hemiparesis, nystagmus, circling, and head tilt.

Clinical Findings: Bloodwork performed during the initial seizure workup revealed hypercalcemia and hypercholesterolemia, which were attributed to vitellogenesis given the bird's previous egg-laying history and recent onset of reproductive behavior. Magnetic resonance imaging of the brain revealed diffuse right pallium atrophy with multifocal hydrocephalus ex vacuo, which were believed to be the result of the previous TBI. Read More

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http://dx.doi.org/10.2460/javma.256.10.1145DOI Listing

Screening for primary hyperparathyroidism in a tertiary stone clinic, a useful endeavor.

Int Urol Nephrol 2020 May 1. Epub 2020 May 1.

Department of Urology, University of Alabama-Birmingham, Faculty Office Tower 1107, 510 20th Street South, Birmingham, AL, 35249, USA.

Introduction And Objectives: Primary hyperparathyroidism (1HPT) is associated with the risk of developing kidney stones. Our objective was to determine the prevalence of 1HPT amongst SF evaluated at a tertiary stone clinic and determine if it is cost-effective to screen for this condition.

Methods: We retrospectively reviewed 742 adult SF seen by a single urologic surgeon from 2012 to 2017 all of who were screened for 1HPT with an intact serum PTH (iPTH) and calcium. Read More

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http://dx.doi.org/10.1007/s11255-020-02476-0DOI Listing

Vitamin D as a Potential Therapy for Multiple Sclerosis: Where Are We?

Int J Mol Sci 2020 Apr 28;21(9). Epub 2020 Apr 28.

Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY 11548, USA.

Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system and is caused by an aberrant immune response to myelin sheath. Disease-modifying medications, which mainly aim to suppress such aberrant immune response, have significantly improved MS treatment. However, the disease severity continues to worsen. Read More

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http://dx.doi.org/10.3390/ijms21093102DOI Listing

Long-term delivery of alendronate through an injectable tetra-PEG hydrogel to promote osteoporosis therapy.

Biomater Sci 2020 Jun 30;8(11):3138-3146. Epub 2020 Apr 30.

The 8th Medical Center of Chinese PLA General Hospital, Beijing, China.

Pharmacotherapy for hypercalcemia, which is mainly caused by osteoporosis, is an effective method to regulate the in vivo calcium equilibrium. From this perspective, the development of a minimally invasive gelling system for the prolonged local delivery of bisphosphonates has practical significance in the clinical therapy of bone osteoporosis. Here, a biocompatible and injectable hydrogel based on a uniform tetra-PEG network carrying a PEG-modified alendronate (ALN) prodrug for the localized elution and long-term sustained release of anti-osteoporotic small molecule drugs is reported. Read More

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http://dx.doi.org/10.1039/d0bm00376jDOI Listing

Hypercalcemia as an Early Finding of Opportunistic Fungal Pneumonia in Renal Transplantation: A Case Series Report.

Transplant Proc 2020 May 25;52(4):1178-1182. Epub 2020 Apr 25.

Department of Nephrology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Background: Pneumonia caused by opportunistic fungi is a serious complication in immunocompromised patients. Hypercalcemia has been described in renal transplantation associated with Pneumocystis jirovecii (PJP) or Histoplasma capsulatum (HCP) pneumonia.

Methods: We describe 5 patients who underwent kidney transplant between 2014 and 2019 and developed hypercalcemia before the diagnosis of pulmonary fungal infection: 4 patients with PJP and 1 with HCP. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.03.031DOI Listing

Primary hyperparathyroidism.

Best Pract Res Clin Rheumatol 2020 Apr 23:101514. Epub 2020 Apr 23.

Serviço de Endocrinologia e Metabologia do Hospital de Clínicas da Universidade Federal do Paraná (SEMPR), Curitiba, Brazil; Lab Pro, Bone Histomorphometry, Fundação Pro Renal, Curitiba, Brazil. Electronic address:

Primary hyperparathyroidism (PHPT) is a condition that affects calcium metabolism due to parathyroid hormone (PTH) hypersecretion leading to hypercalcemia. Manifestations have changed over time, from a symptomatic disease with bone pain, fractures, nephrolithiasis, and muscle weakness, to a condition that is mainly asymptomatic (80-90%). Typical symptoms and signs occur in the bones and kidneys and atypical manifestations are cardiovascular, neuropsychiatric and cognitive, neuromuscular, rheumatological, and gastrointestinal. Read More

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http://dx.doi.org/10.1016/j.berh.2020.101514DOI Listing

Acute Pancreatitis with Hypercalcemia as Initial Manifestation of Multiple Myeloma.

Korean J Gastroenterol 2020 Apr;75(4):220-224

Devision of Gastroenterology, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.

A case of acute pancreatitis associated with hypercalcemia resulting from a newly diagnosed multiple myeloma is reported. There have been several prior reports of hypercalcemia-induced pancreatitis in patients with multiple myeloma, but very few showed the following two aspects: pancreatitis as the first manifestation of hematologic malignancy and recovery after serum calcium levels fell into normal range. When clinicians encounter a patient with hypercalcemic status and acute pancreatitis without any known etiology of pancreatitis, multiple myeloma as a root cause of pancreatitis should be considered. Read More

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http://dx.doi.org/10.4166/kjg.2020.75.4.220DOI Listing

Mid-Term and Long-Term Impact of Permanent Hypoparathyroidism After Total Thyroidectomy.

World J Surg 2020 Apr 22. Epub 2020 Apr 22.

Service of Endocrine and Advanced Laparoscopic Surgery/Department of Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Vasco de Quiroga 15, Seccion XVI, Tlalpan, 14000, Mexico City, Mexico.

Background: Permanent hypoparathyroidism (PH) is the most frequent long-term complication after total thyroidectomy. PH is related to many short-term and long-term complications, including clinical manifestations of hypocalcemia, hypercalcemia due to overtreatment, hyperphosphatemia, gastrointestinal, neuropsychiatric symptoms, decrease in renal function and infectious complications. The aim of this study was to identify the most frequent effects of PH and its associated risk factors. Read More

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http://dx.doi.org/10.1007/s00268-020-05531-0DOI Listing

A Dimorphic Diagnosis of a Pleomorphic Disease: An Unusual Cause of Hypercalcemia.

Am J Med 2020 Apr 19. Epub 2020 Apr 19.

Division of Infectious Diseases; Mayo Clinic, Rochester, Minn.

Background: Histoplasmosis is a rare cause of 1, 25-dihydroxy vitamin-D-mediated hypercalcemia. In this study, we report 2 cases of hypercalcemia secondary to histoplasmosis seen at Mayo Clinic, Rochester and a review of cases reported in the literature.

Methods: We conducted a PubMed search using the keywords "hypercalcemia" and "histoplasmosis. Read More

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http://dx.doi.org/10.1016/j.amjmed.2020.03.035DOI Listing

Early stage IgD multiple myeloma in a 50-year-old man.

Proc (Bayl Univ Med Cent) 2020 Apr 23;33(2):263-265. Epub 2019 Dec 23.

Department of Oncology, Charles A. Sammons Cancer Center, Baylor University Medical CenterDallasTexas.

We present the case of a 50-year-old Hispanic man who presented to the emergency department with an acute right femur fracture after 3 months of intermittent discomfort in the right leg. He was eventually diagnosed with immunoglobulin D (IgD) multiple myeloma, a rare class of myeloma that is often of advanced stage at diagnosis. Fortunately, our patient was stage I at diagnosis and did not have hypercalcemia, anemia, or renal insufficiency, as is common with myeloma. Read More

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http://dx.doi.org/10.1080/08998280.2019.1698878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155962PMC

Management of Urgent Medical Conditions at the End of Life.

Med Clin North Am 2020 May 14;104(3):525-538. Epub 2020 Feb 14.

Division of Palliative Medicine, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: https://twitter.com/ctsinclair.

Medical emergencies at the end of life require recognition of patients at risk, so that a comprehensive assessment and plan of care can be put in place. Frequently, the interventions depend on the patient's underlying prognosis, location of care, and goals of care. The mere presence of a medical emergency often rapidly changes an estimated prognosis. Read More

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http://dx.doi.org/10.1016/j.mcna.2019.12.006DOI Listing