20,051 results match your criteria Milk-Alkali Syndrome


Effect of hyperparathyroidism on coagulation: A global assessment by modified rotation thromboelastogram (ROTEM).

Turk J Med Sci 2021 May 7. Epub 2021 May 7.

Objective: Hyperparathyroidism is an endocrine disorder characterized by hypercalcemia. Because of calcium?s effects on parathyroid glands, bone, intestine and kidney, it has an important place in homeostasis. The results of studies regarding hyperparathyroidism hemostasis are conflicting. Read More

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Tertiary hyperparathyroidism: a review.

Clin Ter 2021 May;172(3):241-246

Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy.

Abstract: Tertiary hyperparathyroidism (HPT III) occurs when an excess of parathyroid hormone (PTH) is secreted by parathyroid glands, usually after longstanding secondary hyperparathyroidism. Some authorities reserve the term for secondary hyperparathyroidism that persists after successful renal transplantation. Long-standing chronic kidney disease (CKD) is associated with several metabolic disturbances that lead to increased secretion of PTH, including hyperphosphatemia, calcit-riol deficiency, and hypocalcaemia. Read More

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Efficacy of a low-dose praziquantel and fenbendazole protocol in the treatment of asymptomatic schistosomiasis in dogs.

J Vet Intern Med 2021 May 6. Epub 2021 May 6.

Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.

Background: Established treatment protocols for schistosomiasis (Heterobilharzia americana) in dogs are expensive. Anecdotal reports suggest that lower doses of praziquantel, combined with fenbendazole, may eliminate asymptomatic infections.

Objectives: Evaluate the efficacy of a low-dose praziquantel and fenbendazole protocol to manage asymptomatic schistosomiasis in dogs and compare fecal saline sedimentation (FSS) and fecal PCR (FPCR) for therapeutic monitoring. Read More

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Evaluation of a Pharmacy-Driven Calcitonin Protocol for Treating Hypercalcemia in Hospitalized Patients: A Multisite Study.

J Pharm Pract 2021 May 6:8971900211013187. Epub 2021 May 6.

Department of Pharmacy, Health First Holmes Regional Medical Center, Melbourne, FL, USA.

Background: The dramatic increase in the acquisition cost of injectable calcitonin led to creating a pharmacy-driven calcitonin protocol to improve the appropriate use of calcitonin and other treatment modalities for hypercalcemia.

Objective: This study aimed to characterize the use of calcitonin before and after implementation of a pharmacy-driven calcitonin protocol.

Methods: This was a multi-center, retrospective study of the use of injectable calcitonin in adult hospitalized patients with hypercalcemia. Read More

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When a maternal heterozygous mutation of the CYP24A1 gene leads to infantile hypercalcemia through a maternal uniparental disomy of chromosome 20.

Mol Cytogenet 2021 May 5;14(1):23. Epub 2021 May 5.

Normandie Univ, UNIROUEN, Inserm U1245 and Rouen University Hospital, Department of Genetics and Reference Center for Developmental Disorders, Normandy Center for Genomic and Personalized Medicine, 76000, Rouen, France.

Background: Infantile hypercalcemia is an autosomal recessive disorder caused either by mutations in the CYP24A1 gene (20q13.2) or in the SLC34A1 gene (5q35.3). Read More

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A peculiar manifestation and clinical course of occult primary hyperparathyroidism: a case report.

Acta Biomed 2021 Apr 30;92(S1):e2021155. Epub 2021 Apr 30.

Department of Medicine and Surgery, General Surgery Unit, Parma University Hospital..

We present the clinical case of a patient who developed acute hypercalcemia diagnosed after presenting acute pancreatitis.Male patient, age 67, arrived at the Emergency Department of the University Hospital of Parma for upper abdominal pain, radiated to the back, and associated with nausea. Laboratory tests showed elevation of lipase, serum calcium levels, PTH levels and serum creatinine. Read More

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Vitamin D Poisoning; Hypercalcemia in a Case with Richter Transformation.

Acta Biomed 2021 Apr 30;92(S1):e2021146. Epub 2021 Apr 30.

Department of Emergency Medicine, Cerrahpasa Faculty of Medicine, Istanbul University Cerrahpasa.

In addition to modern medicine, the search for complementary and alternative medicine has been present for malignancy patients in every period. Confusion, polyuria, polydipsia, anorexia, vomiting, and muscle weakness are symptoms of acute poisoning and are related to hypercalcemia. In our case, a 52-year-old male patient applied to the Emergency Department(ED) with abdominal pain and weakness for two days. Read More

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Plasma Cell Proliferation Is Reduced in Myeloma-Induced Hypercalcemia and in Co-Culture with Normal Healthy BM-MSCs.

Lab Med 2021 May;52(3):273-289

Department of Hematology and Blood Banking, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Objective: In multiple myeloma (MM), stimulation of osteoclasts and bone marrow (BM) lesions lead to hypercalcemia, renal failure, and anemia. Co-culture of the myeloma cells in both hypocalcemia and hypercalcemia concentrations with bone marrow-mesenchymal stem cells were evaluated.

Materials And Methods: Viability and survival of myeloma cells were assessed by microculture tetrazolium test and flow cytometric assays. Read More

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Economic burden of disease progression among multiple myeloma patients who have received transplant and at least one line of therapy in the US.

Blood Cancer J 2021 Feb 16;11(2):35. Epub 2021 Feb 16.

Policy Analysis Inc., Chestnut Hill, MA, USA.

Effects of disease progression on healthcare resource utilization (HRU) and costs among multiple myeloma (MM) patients with ≥1 line of therapy (LOT) who received their first stem cell transplant (SCT) within 1 year of initial MM diagnosis were estimated using a large US claims database. Disease progression was defined as advancement to the next LOT, bone metastasis, hypercalcemia, soft tissue plasmacytoma, skeletal related events, acute kidney disease, or death within 12 months of LOT initiation. Annual HRU and costs in the first three LOTs (L1-L3) were compared for patients with versus without disease progression using inverse probability of treatment weighting to adjust for differences between groups in baseline characteristics. Read More

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February 2021

Squamous Cell Carcinoma of the Lung in McCune-Albright Syndrome.

Cureus 2021 Mar 28;13(3):e14159. Epub 2021 Mar 28.

Internal Medicine, Detroit Medical Center (DMC) Harper Hospital, Detroit, USA.

McCune Albright Syndrome (MAS) is caused by a mutation in the GNAS gene that results in multiple endocrinopathies such as Cushing syndrome, acromegaly, hyperthyroidism, and precocious puberty. Despite the presence of pleiotropy coupled with a GNAS gene mutation, malignancy is a rare occurrence in MAS. There is minimal literature showcasing squamous cell carcinoma (SCC) of the lung in patients with MAS. Read More

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"Primary Hyperparathyroidism (PHPT) in Children: Two Case Reports and Review of the Literature".

Case Rep Endocrinol 2021 13;2021:5539349. Epub 2021 Apr 13.

Department of Pediatric Endocrinology, Regina Margherita Children's Hospital of Turin, Turin, Italy.

Primary hyperparathyroidism (PHPT) is a rare disorder in children and adolescents. Typical biochemical features are hypercalcemia and hypophosphatemia, but the clinical features can be heterogeneous, and in some cases, symptoms are vague and nonspecific, leading to misdiagnosis or late diagnosis. Herein, we report two cases of PHPT in pediatric age with different presenting symptoms, pain in the foot, and progressive alteration of the gait in the first case and recurrent abdominal pain with emotional lability in the second. Read More

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Long-standing hypercalcemia in a 78-years old woman.

Clin Case Rep 2021 Apr 24;9(4):2492-2493. Epub 2021 Feb 24.

Department of Surgery "Hygeia Hospital" Athens Greece.

A 78 years-old woman was found with worsening hypercalcemia, osteopenia and memory loss during the past 2 years. Multiple, repeated imaging studies failed to reveal the etiology of the primary hyperparathyroidism. Bilateral neck exploration revealed a 4. Read More

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Subcutaneous fat necrosis of the newborn - An atypical case with typical complications.

Clin Case Rep 2021 Apr 18;9(4):2069-2073. Epub 2021 Feb 18.

Department of Pediatrics Hospital Garcia de Orta, EPE Lisbon Portugal.

Subcutaneous fat necrosis of the newborn should be considered in newborns with suggestive skin lesions, even in the absence of perinatal distress. SCFN may cause long-standing complications, like hypertriglyceridemia or hypercalcemia. Hypercalcemia can be refractory to therapy and lead to poor weight gain and nephrocalcinosis, which should be closely monitored. Read More

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PTHrP-induced hypercalcemia in paragangliomas: Tumor dedifferentiation as sign of bad prognosis.

Endocrinol Diabetes Nutr 2021 Apr 29. Epub 2021 Apr 29.

Endocrinology and Nutrition Service, Reina Sofia University Hospital, Córdoba, Spain. Electronic address:

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Heterobilharzia americana infection in dogs: A retrospective study of 60 cases (2010-2019).

J Vet Intern Med 2021 May 2. Epub 2021 May 2.

Department of Clinical Sciences, College of Veterinary Medicine, Texas A&M University, College Station, Texas, USA.

Background: The trematode Heterobilharzia americana (HA) causes granulomatous gastrointestinal and hepatic disease in dogs. Before 2008, diagnosis relied on saline fecal sedimentation or histopathology, and earlier reports primarily described dogs with advanced disease or cases diagnosed incidentally at necropsy. The advent of a fecal PCR test has facilitated the diagnosis of HA and provided insights into manifestations and response to treatment. Read More

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Acromegaly and non-parathyroid hormone-dependent hypercalcemia: a case report and literature review.

BMC Endocr Disord 2021 May 1;21(1):90. Epub 2021 May 1.

Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, 610041, Chengdu, China.

Background: Hypercalcemia associated with acromegaly is mostly parathyroid hormone (PTH)-dependent, being caused by parathyroid hyperplasia or adenoma, which are common in individuals with multiple endocrine adenomatosis-1 (MEN-1). The rare occurrence of non-PTH-dependent hypercalcemia associated with acromegaly is attributable to complex factors involving increased intestinal calcium absorption, enhanced bone calcium release, and reduced urinary calcium elimination. Although patients with acromegaly often have mild hyperphosphatemia and hypercalciuria, clinically significant hypercalcemia is extremely rare. Read More

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Predictors of adenoma size and location in primary hyperparathyroidism.

Langenbecks Arch Surg 2021 Apr 30. Epub 2021 Apr 30.

Medical Campus University of Oldenburg, School of Medicine and Health Sciences, University Hospital for Visceral Surgery, Pius-Hospital Oldenburg, Georgstr. 12, 26121, Oldenburg, Germany.

Purpose: In primary hyperparathyroidism (PHPT), intraoperative localization of the parathyroid adenoma can be challenging, especially in cases of negative preoperative imaging. Since a focused unilateral parathyroidectomy has benefits compared to a conventional bilateral neck exploration, the question arises whether adenoma size prediction can facilitate a targeted approach. We investigated whether single parathyroid adenoma size can be estimated using preoperative parathyroid hormone (PTH), calcium, and phosphate in patients with PHPT. Read More

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The role of calcium-sensing receptor signaling in regulating transepithelial calcium transport.

Exp Biol Med (Maywood) 2021 Apr 29:15353702211010415. Epub 2021 Apr 29.

Department of Physiology, University of Alberta, Edmonton T6G 1C9, Canada.

The calcium-sensing receptor (CaSR) plays a critical role in sensing extracellular calcium (Ca) and signaling to maintain Ca homeostasis. In the parathyroid, the CaSR regulates secretion of parathyroid hormone, which functions to increase extracellular Ca levels. The CaSR is also located in other organs imperative to Ca homeostasis including the kidney and intestine, where it modulates Ca reabsorption and absorption, respectively. Read More

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Primary Hyperparathyroidism: A Narrative Review of Diagnosis and Medical Management.

J Clin Med 2021 Apr 9;10(8). Epub 2021 Apr 9.

Division of Endocrinology and Metabolism, McMaster University, Hamilton, ON L8S 4L8, Canada.

Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia in the outpatient setting. Symptomatic presentation includes non-specific signs and symptoms of hypercalcemia, skeletal fragility, nephrolithiasis and nephrocalcinosis. The majority of individuals present at an asymptomatic stage following routine biochemical screening, without any signs or symptoms of calcium or parathyroid hormone (PTH) excess or target organ damage. Read More

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Role of LncRNA score and PVT1 in primary hyperparathyroidism-- a preliminary study.

J Otolaryngol Head Neck Surg 2021 Apr 28;50(1):30. Epub 2021 Apr 28.

Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, No.10 Tieyi Road, Haidian District, Beijing, 100038, China.

Background: Dysregulated lncRNA score and PVT1 expression may be involved in cancer. However, relationships of lncRNAs with hyperparathyroidism and parathyroid cancer (PC) diagnosis remain mysterious.

Methods: Using quantitative real-time polymerase chain reaction (RT-qPCR), expression profile of PVT1 was evaluated in 57 patients with primary hyperparathyroidism, including 11 with parathyroid cancer (PC) and 46 with parathyroid adenoma (PA). Read More

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Nonfunctional parathyroid cancer a case report.

Rozhl Chir 2021 ;100(3):133-137

Introduction: Parathyroid cancer is a rare endocrine malignancy. These tumors are typically functional, causing severe hypercalcemia due to primary hyperparathyroidism. Nonfunctional parathyroid cancer with normal serum calcium and parathyroid hormone levels is extremely rare. Read More

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Causes of hypercalcemia in renal transplant recipients: persistent hyperparathyroidism and others.

Braz J Med Biol Res 2021 26;54(6):e10558. Epub 2021 Apr 26.

Divisão de Nefrologia, Departamento de Clinica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

Hypercalcemia is common in patients after kidney transplantation (KTx) and is associated with persistent hyperparathyroidism in the majority of cases. This retrospective, single-center study evaluated the prevalence of hypercalcemia after KTx. KTx recipients were evaluated for 7 years after receiving kidneys from living or deceased donors. Read More

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Pediatric hyperparathyroidism: review and imaging update.

Pediatr Radiol 2021 Apr 27. Epub 2021 Apr 27.

Department of Radiology, University of Washington School of Medicine, Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA, 98105, USA.

Hyperparathyroidism, due to increased secretion of parathyroid hormones, may be primary, secondary or tertiary. Most pediatric patients with sporadic primary hyperparathyroidism will be symptomatic, presenting with either end-organ damage or nonspecific symptoms. In younger patients with primary hyperparathyroidism, there is a higher prevalence of familial hyperparathyroidism including germline inactivating mutations of the calcium-sensing receptor genes that result in either neonatal severe hyperparathyroidism or familial hypocalciuric hypercalcemia. Read More

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An infant with congenital nephrogenic diabetes insipidus presenting with hypercalcemia and hyperphosphatemia.

Endocrinol Diabetes Metab Case Rep 2021 Apr 1;2021. Epub 2021 Apr 1.

Department of Pediatrics, Keio University School of Medicine, shinjyuku, Tokyo, Japan.

Summary: We report a male infant with congenital nephrogenic diabetes insipidus (NDI) who presented with hypercalcemia and hyperphosphatemia since birth. Serum sodium started to increase at 39 days. Although there was no polyuria, urine osmolality was 71 mOsm/kg, when serum osmolality was 296 mOsm/kg with plasma arginine vasopressin 22. Read More

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Cognitive impairment reversed by cinacalcet administration in primary hyperparathyroidism.

Hormones (Athens) 2021 Apr 21. Epub 2021 Apr 21.

Department of Diabetes and Endocrinology, University Hospital Hairmyres, East Kilbride, UK.

Primary hyperparathyroidism (pHPT) is a common endocrine disorder. Often serum calcium is minimally elevated with few symptoms. In elderly patients with multiple co-morbidities, the decision to "watch and wait" is often most clinically appropriate as operative intervention is associated with high peri-operative risk. Read More

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Restoring Tissue Homeostasis at Metastatic Sites: A Focus on Extracellular Vesicles in Bone Metastasis.

Front Oncol 2021 22;11:644109. Epub 2021 Mar 22.

Department of Health Sciences, Università degli Studi di Milano, Milano, Italy.

Bone is the most common site of cancer metastasis and the spread of cancer cells to the bone is associated with poor prognosis, pain, increased risk of fractures, and hypercalcemia. The bone marrow microenvironment is an attractive place for tumor dissemination, due to the dynamic network of non-malignant cells. In particular, the alteration of the bone homeostasis favors the tumor homing and the consequent osteolytic or osteoblastic lesions. Read More

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Primary hyperparathyroidism in a child with abdominal pain and hematuria.

Clin Pediatr Endocrinol 2021 3;30(2):111-113. Epub 2021 Apr 3.

Department of Pediatrics, Dokkyo Medical University Saitama Medical Center, Saitama, Japan.

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Duplex high resolution melting analysis (dHRMA) to detect two hot spot CYP24A1 pathogenic variants (PVs) associated to idiopathic infantile hypercalcemia (IIH).

Mol Biol Rep 2021 Apr 17. Epub 2021 Apr 17.

UOS Diagnostica Molecolare E Genomica, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Largo Agostino Gemelli, 00168, Rome, Italy.

Pathogenic variants (PVs) in CYP24A1 gene are associated with Idiopathic Infantile Hypercalcemia disease (IIH). The identification of CYP24A1 PVs can be a useful tool for the improvement of target therapeutic strategies. Aim of this study is to set up a rapid and inexpensive High Resolution Melting Analysis (HRMA)-based method for the simultaneous genotyping of two hot spot PVs in CYP24A1 gene, involved in IIH. Read More

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Debulking surgery for functional pleural dissemination of parathyroid carcinoma-case report.

J Cardiothorac Surg 2021 Apr 15;16(1):86. Epub 2021 Apr 15.

Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, 2-2-L5, Yamadaoka, Suita, 565-0871, Osaka, Japan.

Background: A rare cause of primary hyperparathyroidism (PHPT) is a parathyroid carcinoma. Hypercalcemia with an elevated parathyroid hormone (PTH) level seen in recurrent and metastasis disease cases is often refractory to medical therapy, thus surgical resection is recommended when possible. We performed debulking surgery for pleural dissemination of parathyroid cancer for improvement of symptoms in a patient with hypercalcemia. Read More

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Differential diagnosis of vitamin D-related hypercalcemia using serum vitamin D metabolite profiling.

J Bone Miner Res 2021 Apr 15. Epub 2021 Apr 15.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada, K7L3N6.

Genetic causes of vitamin D-related hypercalcemia are known to involve mutation of 25-hydroxyvitamin D-24-hydroxylase CYP24A1 or the sodium phosphate co-transporter SLC34A1; which result in excessive 1,25-(OH) D hormonal action. However, at least 20% of idiopathic hypercalcemia (IH) cases remain unresolved. In this case-control study, we used precision vitamin D metabolite profiling based on LC-MS/MS of an expanded range of vitamin D metabolites - to screen German and French cohorts of hypercalcemia patients, to identify patients with altered vitamin D metabolism where involvement of CYP24A1 or SLC34A1 mutation had been ruled out, and possessed normal 25-OH-D :24,25-(OH) D ratios. Read More

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