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    18113 results match your criteria Milk-Alkali Syndrome

    1 OF 363

    A case of hypercalcemia with double pathology.
    J Community Hosp Intern Med Perspect 2017 Jul 13;7(3):178-181. Epub 2017 Jul 13.
    Hurley Medical Center, Michigan State University, Flint, MI, USA.
    Hypercalcemia has many causes including primary hyperparathyroidism, malignancy, and other rare etiologies. In most of the cases, hypercalcemia is secondary to one etiology. In this case, we are reporting hypercalcemia with two causes. Read More

    How much is too much? Two contrasting cases of excessive vitamin D supplementation.
    Clin Chim Acta 2017 Aug 8. Epub 2017 Aug 8.
    Department of Pathology, UC San Diego Health, San Diego, CA, United States. Electronic address:
    Background: In this report, we describe 2 contrasting cases of hypervitaminosis D.

    Case Presentation: Patient 1 was a 75-y old man who developed symptomatic hypercalcemia (peak serum calcium concentration of 15.3mg/dl; reference range: 8. Read More

    Multiple Osteolytic Lesions Causing Hypercalcemia: A Rare Presentation of Acute Lymphoblastic Leukemia.
    Case Rep Med 2017 17;2017:2347810. Epub 2017 Jul 17.
    Civil Hospital Karachi, Dow University of Health Sciences, Karachi, Pakistan.
    Acute lymphoblastic leukemia is characterized by unchecked proliferation of malignant lymphoblasts which replaces the normal bone marrow culminating in anemia due to red blood cells inadequacy as well as in easy bruising/bleeding secondary to insufficient platelets production. Even the white blood cells which are produced excessively are immature and abnormal. ALL is the most common hematological malignancy in children. Read More

    Effects of calcium on the incidence of recurrent colorectal adenomas: A systematic review with meta-analysis and trial sequential analysis of randomized controlled trials.
    Medicine (Baltimore) 2017 Aug;96(32):e7661
    aSchool of Pharmacy/School of Postgraduate Studies, International Medical University, Kuala Lumpur bDepartment of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia cMalaysian Research Institute on Ageing, Universiti Putra Malaysia, Serdang, Malaysia dClinical School, Department of Surgery, International Medical University, Seremban, Negeri Sembilan, Malaysia eCenter of Health Outcomes Research and Therapeutic Safety (Cohorts), School of Pharmaceutical Sciences, University of Phayao, Thailand fSchool of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia gCenter of Pharmaceutical Outcomes Research, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok hUnit of Excellence on Herbal Medicine, School of Pharmaceutical Sciences, University of Phayao iDivision of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand jSchool of Pharmacy, University of Wisconsin, Madison, USA kAsian Centre for Evidence Synthesis in Population, Implementation and Clinical Outcomes (PICO), Health and Well-being Cluster, Global Asia in the 21st Century (GA21) Platform, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia.
    Background: Protective effects of calcium supplementation against colorectal adenomas have been documented in systematic reviews; however, the results have not been conclusive. Our objective was to update and systematically evaluate the evidence for calcium supplementation taking into consideration the risks of systematic and random error and to GRADE the evidence.

    Methods: The study comprised a systematic review with meta-analysis and trial sequential analysis (TSA) of randomized controlled trials (RCTs). Read More

    Serum Hepcidin Levels in Multiple Myeloma.
    Clin Lab 2017 Jul;63(7):1273-1277
    Background: Multiple myeloma (MM) is a malignant disease with a 10% frequency among all haematology neoplasms. It is characterized by clone proliferation of plasmatic cells in bone marrow, monoclonal gammopathy, and anemia, hypercalcemia, and kidney failure and bone lesions. IL-6 is an inflammatory cytokine, potential growth factor for myeloma cells, as elevated serum levels are connected with poor disease prognosis. Read More

    A curious case of growth failure and hypercalcemia: Answers.
    Pediatr Nephrol 2017 Aug 7. Epub 2017 Aug 7.
    Division of Nephrology, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
    Background: Sarcoidosis is a multisystem granulomatous disease of unknown etiology that rarely presents in childhood. Here, we report a case of pediatric sarcoidosis, presenting with renal failure and hypercalcemia.

    Case Diagnosis/treatment: A previously well 14-year-old Caucasian boy was admitted to the Hospital for Sick Children, Canada, for hypertension and renal failure following work-up by his family physician for initial concerns of growth failure. Read More

    A curious case of growth failure and hypercalcemia: Questions.
    Pediatr Nephrol 2017 Aug 7. Epub 2017 Aug 7.
    Division of Nephrology, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
    Background: Sarcoidosis is a multisystem granulomatous disease of unknown etiology that rarely presents in childhood. Here, we report a case of pediatric sarcoidosis presenting with renal failure and hypercalcemia.

    Case Diagnosis/treatment: A previously well 14-year-old Caucasian boy was admitted to the Hospital for Sick Children, Canada, for hypertension and renal failure following work-up by his family physician for initial concerns of growth failure. Read More

    An acute phase reaction with intravenous bisphosphonate use in a patient with recently diagnosed Graves' disease.
    Clin Case Rep 2017 Aug 19;5(8):1226-1229. Epub 2017 Jun 19.
    Macarthur Diabetes and Endocrine CentreCampbelltown HospitalCampbelltownNew South WalesAustralia.
    Given the immune background, we hypothesize that active Grave's hyperthyroidism is a risk factor for an acute phase reaction associated with the use of bisphosphonates. We recommend that in patients with Graves' thyrotoxicosis and hypercalcemia, consider the risk of an acute phase reaction if planning to give bisphosphonate therapy. Read More

    Systemic Sarcoidosis with Thyroid Involvement.
    Intern Med 2017 Aug 1. Epub 2017 Aug 1.
    Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University, Japan.
    A 66-year-old woman, who was diagnosed with iritis, visited our hospital due to general malaise. A blood analysis revealed hypercalcemia. Computed tomography revealed mediastinal and hilar lymph node hyperplasia. Read More

    The effect of primary hyperparathyroidism on pancreatic exocrine function.
    J Endocrinol Invest 2017 Aug 2. Epub 2017 Aug 2.
    Department of Endocrinology and Metabolism, Uludag University Medical School, Bursa, Turkey.
    Background: Elastase-1 is a proteolytic enzyme secreted by pancreatic acinar cells, and measurements of the concentration this enzyme are used to evaluate pancreatic exocrine function. We aimed to determine whether pancreatic exocrine function declines due to chronic hypercalcemia by measuring fecal elastase levels.

    Methods: 75 patients with primary hyperparathyroidism (18 men and 47 women) and 30 healthy subjects (11 men and 19 women) participated in this study. Read More

    The future: advances in therapeutic approach and management strategies for MEN1.
    Endocr Relat Cancer 2017 Aug 2. Epub 2017 Aug 2.
    G Valk, Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, Netherlands.
    Multiple endocrine neoplasia type 1 is a rare autosomal inherited disorder associated with a high risk for patients to simultaneously develop tumours of the parathyroid glands, duodeno-pancreatic neuroendocrine tumors and tumors of the anterior pituitary gland. Early identification of MEN1 in patients enables presymptomatic screening of manifestations which makes timely interventions possible with the intention to prevent morbidity and mortality. Causes of death nowadays have shifted towards local or metastatic progression of malignant neuro endocrine tumors. Read More

    Similar survival outcomes in patients with biclonal versus monoclonal myeloma: a multi-institutional matched case-control study.
    Ann Hematol 2017 Aug 1. Epub 2017 Aug 1.
    Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
    Multiple myeloma is a plasma cell malignancy characterized by clonal proliferation of plasma cells in the bone marrow and associated organ damage. Usually, patients with myeloma present with a single monoclonal protein in serum and/or urine constituted by one heavy chain and one light chain. In less than 5% of the patients, more than one monoclonal protein can be identified. Read More

    Association of calcium sensing receptor polymorphisms at rs1801725 with circulating calcium in breast cancer patients.
    BMC Cancer 2017 Aug 2;17(1):511. Epub 2017 Aug 2.
    Department of Biochemistry and Cancer Biology, School of Graduate Studies and Research, Meharry Medical College, Nashville, TN, 37208, USA.
    Background: Breast cancer (BC) patients with late-stage and/or rapidly growing tumors are prone to develop high serum calcium levels which have been shown to be associated with larger and aggressive breast tumors in post and premenopausal women respectively. Given the pivotal role of the calcium sensing receptor (CaSR) in calcium homeostasis, we evaluated whether polymorphisms of the CASR gene at rs1801725 and rs1801726 SNPs in exon 7, are associated with circulating calcium levels in African American and Caucasian control subjects and BC cases.

    Methods: In this retrospective case-control study, we assessed the mean circulating calcium levels, the distribution of two inactivating CaSR SNPs at rs1801725 and rs1801726 in 199 cases and 384 age-matched controls, and used multivariable regression analysis to determine whether these SNPs are associated with circulating calcium in control subjects and BC cases. Read More

    Gastric Pneumatosis from Isolated Gastric Calciphylaxis.
    ACG Case Rep J 2017 19;4:e91. Epub 2017 Jul 19.
    Department of Gastroenterology, University of Cincinnati Medical Center, Cincinnati, OH.
    A 58-year-old man with end-stage renal disease presented with hypotension and emesis, pale conjunctivae, and a distended abdomen. Labs revealed hypercalcemia and leukocytosis. Abdominal imaging showed gastric pneumatosis. Read More

    Sequential, Autologous Hematopoietic Stem Cell Transplant Followed by Renal Transplant in Multiple Myeloma.
    Indian J Nephrol 2017 Jul-Aug;27(4):324-326
    Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India.
    A 30-year-old female was symptomatic with headache, fatigue, and weakness since October 2011 and was told to have anemia. In January 2012, she was admitted outside with pulmonary edema. Investigations revealed advanced azotemia, anemia, and hypercalcemia. Read More

    Hypercalcemia in Lung Cancer due to Simultaneously Elevated PTHrP and Ectopic Calcitriol Production: First Case Report.
    Case Rep Oncol Med 2017 2;2017:2583217. Epub 2017 Jul 2.
    Nephrology Division, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA.
    Calcitriol-mediated hypercalcemia has been reported in malignant lymphomas and granulomatous diseases but not in lung carcinoma. We describe a patient with squamous cell lung carcinoma with hypercalcemia and elevated calcitriol levels. A 60-year-old Caucasian male patient with stage IIIB squamous cell lung cancer developed hypercalcemia at 14. Read More

    Milk-Alkali syndrome induced by H1N1 influenza vaccine.
    Saudi J Kidney Dis Transpl 2017 Jul-Aug;28(4):912-915
    Department of Internal Medicine, Division of Nephrology, King Fahd Hospital of the University, Al-Khobar, Saudi Arabia.
    Milk-Alkali syndrome (MAS) consists of a triad of hypercalcemia, metabolic alkalosis, and acute renal failure. We hereby report a 75-year-old Indian gentleman who presented to our emergency department with a history of generalized weakness and easy fatigability. Investigations were consistent with MAS secondary to calcium carbonate and calcitriol treatment to prevent osteoporosis, aggravated by H1N1 influenza vaccine. Read More

    [Disseminated osteolytic lesions in a 28-year-old refugee].
    Internist (Berl) 2017 Jul 26. Epub 2017 Jul 26.
    Klinik und Poliklinik für Innere Medizin III, Universitätsklinikum Gießen und Marburg, Standort Gießen, 35392, Gießen, Deutschland.
    A 28-year-old Syrian refugee presented with right-sided knee pain and progressive deterioration of the general condition over the past months. Laboratory diagnostics revealed severe hypercalcemia due to primary hyperparathyroidism, and computed tomography (CT) scanning demonstrated disseminated osteolytic lesions throughout the skeleton. Histologically, these lesions were characterized by multinuclear giant cells (defining these lesions as so-called brown tumors). Read More

    A case of hypercalcaemia in an immunocompetent patient with Mycobacterium avium intracellulare.
    JRSM Open 2017 Jul 6;8(7):2054270417716614. Epub 2017 Jul 6.
    Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.
    Mycobacterium avium intracellulare infection or colonization should be considered in the differential diagnosis of hypercalcemia, especially in immunocompromised individuals, in the appropriate clinical context. Read More

    Cytological Features of the Large Cell Variant of Small Cell Ovarian Carcinoma in Young Patients with Hypercalcemia: Histological Findings and Review of the Literature.
    Acta Cytol 2017 Jul 27. Epub 2017 Jul 27.
    Department of Pathology, Metaxas Memorial Cancer Hospital, Piraeus, Greece.
    Objective: To present the cytological features of a very rare and lethal ovarian neoplasm occurring in the young.

    Study Design: We reviewed the cytological findings as they presented in touch imprints obtained from an ovarian mass sent to our department for frozen section investigation.

    Results: Smears were highly cellular. Read More

    Use of a Technetium99m-Sestamibi Scan to Detect Ipsilateral Double Adenoma in a Patient with Primary Hyperparathyroidism: A Case Report.
    Perm J 2017 ;21
    Associate Director of Trauma Services at Memorial Regional Hospital in Hollywood, FL.
    Introduction: Patients with primary hyperparathyroidism generally have a single parathyroid adenoma that causes excessive excretion of parathyroid hormone. For about 2% to 15% of these patients, a double adenoma is present that involves one lesion on each side of the neck.

    Case Presentation: We describe a case of double parathyroid adenoma causing asymptomatic hypercalcemia. Read More

    Primary hyperparathyroidism associated to thrombocytopenia: an issue to consider?
    Clin Cases Miner Bone Metab 2017 Jan-Apr;14(1):97-100. Epub 2017 May 30.
    Department of General Internal Medicine, Ghent University Hospital, Ghent, Belgium.
    Primary hyperparathyroidism (PHPT) is probably the most common endocrine disorder of the parathyroid glands, causing hypercalcemia. It is diagnosed often in persons with elevated serum calcium levels. However, hematological manifestations, such as thrombocytopenia are less known. Read More

    A case report: hypercalcemia due to vitamin supplementation in a patient with neurofibromatosis.
    Clin Cases Miner Bone Metab 2017 Jan-Apr;14(1):87-88. Epub 2017 May 30.
    College of Osteopathic Medicine, Touro University California, Vallejo, USA.
    A 54-year-old female with history of neurofibromatosis who presented with severe hypercalcemia and renal failure secondary to over supplementation of calcium and vitamin D. Read More

    Cytokines in Endocrine Dysfunction of Plasma Cell Disorders.
    Mediators Inflamm 2017 27;2017:7586174. Epub 2017 Jun 27.
    INSERM U954, Nutrition Génétique et Exposition aux Risques Environnementaux, Medical Faculty, University of Lorraine and Regional University Hospital Center of Nancy, Vandœuvre-lès-Nancy, France.
    Monoclonal gammopathies (MG) are classically associated with lytic bone lesions, hypercalcemia, anemia, and renal insufficiency. However, in some cases, symptoms of endocrine dysfunction are more prominent than these classical signs and misdiagnosis can thus be possible. This concerns especially the situation where the presence of M-protein is limited and the serum protein electrophoresis (sPEP) appears normal. Read More

    Parathyroidectomy for tertiary hyperparathyroidism: A systematic review.
    Am J Otolaryngol 2017 Jun 21. Epub 2017 Jun 21.
    Chicago ENT: Advanced Center for Specialty Care, 3000 North Halsted Street Suite 400, Chicago, IL 60657, USA; Rush University Medical Center, Department of Otorhinolaryngology, 1653 West Congress Parkway, Chicago, IL 60612, USA. Electronic address:
    Objective: Analyze the efficacy and indications for parathyroidectomy as an intervention for tertiary hyperparathyroidism.

    Data Sources: PubMed, MEDLINE, and Cochrane Library databases.

    Review Methods: A systematic literature search was performed using the. Read More

    Can adverse effects of excessive vitamin D supplementation occur without developing hypervitaminosis D?
    J Steroid Biochem Mol Biol 2017 Jul 19. Epub 2017 Jul 19.
    Department of Applied Oral Sciences, Forsyth Institute, Cambridge, MA, USA; Department of Preventive & Community Dentistry, School of Dentistry, University of Rwanda College of Medicine & Health Sciences, Kigali, Rwanda; Department of Oral Health Policy & Epidemiology, Harvard School of Dental Medicine, Boston, MA, USA; Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, USA. Electronic address:
    Vitamin D is a fat-soluble hormone that has endocrine, paracrine and autocrine functions. Consumption of vitamin D-supplemented food & drugs have increased significantly in the last couple of decades due to campaign and awareness programs. Despite such wide use of artificial vitamin D supplements, serum level of 25 hydroxyvitamin D does not always reflect the amount of uptake. Read More

    Case report: rare skeletal manifestations in a child with primary hyperparathyroidism.
    BMC Endocr Disord 2017 Jul 21;17(1):45. Epub 2017 Jul 21.
    Orthopaedic Unit, National Hospital Sri Lanka, Colombo, Sri Lanka.
    Background: Primary hyperparathyroidism (PHPT) is uncommon among children with an incidence of 1:300,000. This diagnosis is often missed in children in contrast to adults where it is detected at a pre symptomatic stage due to routine blood investigations. Etiology of PHPT can be due to adenoma, hyperplasia or rarely carcinoma. Read More

    The biochemical and histological analysis of subcutaneous calcitonin and intramedullary methylprednisolone on bone repair after bone marrow ablation: an experimental comparative study in rats.
    J Exp Orthop 2017 Dec 20;4(1):25. Epub 2017 Jul 20.
    Faculty of Medicine, Department of Orthopaedics and Traumatology, Baskent University, Ankara, Turkey.
    Background: Although, glucocorticoid (GC) and calcitonin-induced changes in bone repair have been studied previously, the exact effects of these on fracture healing remain controversial. Hence, the purpose of this experimental study is to determine biochemical and histological effects of locally administrated GC and systemically administrated calcitonin on the kinetics of healing response after bone marrow ablation in rats.

    Methods: After having undergone marrow ablation, a steroid-treated group of rats (n = 24) received a single dose of intramedullary methylprednisolone (2 mg/kg), a calcitonin-treated group (n = 24) received intermittently administrated subcutaneous salmon calcitonin (16 IU/kg), and a control group (n = 24) received intramedullary saline (25 μl). Read More

    Glucocorticoid sparing effect of zoledronic acid in sarcoid hypercalcemia.
    Arch Osteoporos 2017 Dec 19;12(1):68. Epub 2017 Jul 19.
    Division of Endocrinology and Diabetes, Medanta-The Medicity, Sector 38, Gurgaon, Haryana, 122001, India.
    Introduction: Glucocorticoids are regarded as first-line therapy in the management of hypercalcemia associated with sarcoidosis. However, prolonged glucocorticoid therapy leads to metabolic abnormalities, Cushingoid habitus, and impairment of bone health. This study demonstrates the efficacy and glucocorticoid-sparing effect of zoledronic acid in sarcoid hypercalcemia. Read More

    Two rare manifestations of primary hyperparathyroidism: paralysis and peptic ulcer bleeding.
    Endocrinol Diabetes Metab Case Rep 2017 10;2017. Epub 2017 Jul 10.
    Isfahan University of Medical Sciences Isfahan Endocrine and Metabolism Research Center Ringgold Standard Institution, IsfahanIran.
    Primary hyperparathyroidism revealed by thoracic spine brown tumor and peptic ulcer bleeding is rare. We presented a case of 33-year-old male patient who was admitted with paraplegia. Thoracic spine magnetic resonance imaging (MRI) showed extradural lesion at T4 level. Read More

    Diffuse Increased Sodium Fluoride Gastric Activity in a Patient With Hypercalcemia.
    Clin Nucl Med 2017 Sep;42(9):711-713
    From the Department of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
    Increased extraosseous uptake of sodium fluoride can be visualized because of many different etiologies. A 62-year-old man with a history of osteoporosis had an F-sodium fluoride PET/CT scan for accessing chest pain caused by an accident. The images showed multiple fractures. Read More

    Iron-based phosphate binders: a paradigm shift in the treatment of hyperphosphatemic anemic CKD patients?
    J Nephrol 2017 Jul 17. Epub 2017 Jul 17.
    Department of Nephrology and Dialysis, Alessandro Manzoni Hospital, ASST Lecco, Via dell'Eremo 9/11, 23900, Lecco, Italy.
    The partial correction of anemia and the normalization of phosphate and blood pressure are the mainstay of treatment of patients with chronic kidney disease (CKD). Available anti-hypertensive drugs, erythropoiesis stimulating agents (ESAs) and iron supplements have resolved quite satisfactorily the goal of controlling hypertension and partially correcting anemia. Unfortunately, the treatment of hyperphosphatemia is still far from resolved. Read More

    Repetitive short-span application of extracellular calcium is osteopromotive to osteoprogenitor cells.
    J Tissue Eng Regen Med 2017 Jul 17. Epub 2017 Jul 17.
    Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH.
    Extracellular calcium ([Ca(2+) ]E ) concentration has been suggested to stimulate osteoblastic activity; thus, calcium can be used to enhance fracture healing. However, systemic administration of calcium at high dose levels may cause physiological problems such as hypercalcemia. Short span application of single or repetitive [Ca(2+) ]E stimulus may be suggested as a novel regimen to reduce such side effects. Read More

    Assessing the risk of hypercalcemic crisis in patients with primary hyperparathyroidism.
    J Surg Res 2017 Jul 12. Epub 2017 Jul 12.
    Department of Surgery, University of Wisconsin, Madison, Wisconsin. Electronic address:
    Background: Hypercalcemic crisis (HC) is a potentially life-threatening manifestation of primary hyperparathyroidism (PHPT). This study aimed to identify patients with PHPT at greatest risk for developing HC.

    Methods: This retrospective cohort study included patients with a preoperative calcium of at least 12 mg/dL undergoing initial parathyroidectomy for PHPT from 11/2000 to 03/2016. Read More

    Abnormal Calcium Levels During Trauma Resuscitation Are Associated With Increased Mortality, Increased Blood Product Use, and Greater Hospital Resource Consumption: A Pilot Investigation.
    Anesth Analg 2017 Jul 10. Epub 2017 Jul 10.
    From the *Department Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; †Mountain Track Apps, Philadelphia, Pennsylvania; ‡Division of Traumatology, Surgical Critical Care and Emergency Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; §Department of Surgery, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania; and ‖Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
    Background: Admission hypocalcemia predicts both massive transfusion and mortality in severely injured patients. However, the effect of calcium derangements during resuscitation remains unexplored. We hypothesize that any hypocalcemia or hypercalcemia (either primary or from overcorrection) in the first 24 hours after severe injury is associated with increased mortality. Read More

    Atypical skeletal manifestations of rickets in a familial hypocalciuric hypercalcemia patient.
    Bone Res 2017 27;5:17001. Epub 2017 Jun 27.
    Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
    Familial hypocalciuric hypercalcemia (FHH) is caused by inactivating mutations in the calcium-sensing receptor (CaSR) gene. The loss of function of CaSR presents with rickets as the predominant skeletal abnormality in mice, but is rarely reported in humans. Here we report a case of a 16-year-old boy with FHH who presented with skeletal manifestations of rickets. Read More

    Osteolytic bone lesions, severe hypercalcemia without circulating blasts: unusual presentation of childhood acute lymphoblastic leukemia.
    Pan Afr Med J 2017 28;26:244. Epub 2017 Apr 28.
    Department of Hematology, Farhat Hached Hospital, Sousse Tunisia.
    Hypercalcemia and severe osteolytic lesions are rare complications of acute lymphoblastic leukemia (ALL) in childhood. We report a case of a 3 years old boy who presented with prolonged fever, nausea, vomiting and increasing lower limbs pain. Skeletal X-rays and CT scan showed severe osteolytic lesions of the skull and extremities. Read More

    Profile of Abaloparatide and Its Potential in the Treatment of Postmenopausal Osteoporosis.
    Cureus 2017 May 31;9(5):e1300. Epub 2017 May 31.
    NICHD, National Institute of Health.
    Abaloparatide (previously known as BA058) is a synthetic 34-amino acid peptide and novel selective activator of parathyroid hormone receptor 1 (PTHR1) currently under development as a new anabolic agent in the management of osteoporosis. This paper reviews the profile and potential of abaloparatide in the treatment of postmenopausal osteoporosis. This paper is based on clinical trials and a PubMed search. Read More

    Intrahepatic cholangiocarcinoma producing granulocyte colony-stimulating factor and parathyroid hormone-related protein.
    Nihon Shokakibyo Gakkai Zasshi 2017 ;114(7):1285-1292
    Department of Gastroenterology, Teikyo University Mizonoguchi Hospital.
    A 78-year-old man was referred to our hospital with suspected liver abscess. Fever and inflammatory reaction resolved after percutaneous drainage and administration of antibiotics. However, leukocyte count was remarkably increased, and hypercalcemia was noted. Read More

    Failure to Diagnose Hyperparathyroidism in 10,432 Patients With Hypercalcemia: Opportunities for System-level Intervention to Increase Surgical Referrals and Cure.
    Ann Surg 2017 Jul 3. Epub 2017 Jul 3.
    *Department of Surgery, University of Alabama at Birmingham, Birmingham, AL †Institute for Cancer Outcomes & Survivorship, University of Alabama at Birmingham, Birmingham, AL ‡Kirklin Institute for Research in Surgical Outcomes, University of Alabama at Birmingham, Birmingham, AL.
    Objective: To determine whether a significant number of patients with hyperparathyroidism remain undiagnosed and untreated.

    Background: Failure to diagnose primary hyperparathyroidism and refer patients to surgeons leads to impaired quality of life and increased costs. We hypothesized that many patients with hyperparathyroidism would be untreated due to not considering the diagnosis, inadequate evaluation of hypercalcemia, and under-referral to surgeons. Read More

    Slight hypercalcemia is not associated with positive responses in the Comet Assay in male rat liver.
    Mutat Res 2017 Aug 25;820:26-30. Epub 2017 May 25.
    DSM Nutritional Products AG, Wurmisweg 576, 4303 Kaiseraugst, Switzerland.
    Maintenance of physiological levels of intracellular and extracellular calcium is essential for life. Increased intracellular calcium levels are involved in cell death (apoptosis and necrosis) and are associated with positive responses in the Comet assay in vitro. In addition, high calcium and vitamin D intakes were reported to induce apoptosis in adipose tissue in obese mice and to increase DNA-migration in the Comet assay. Read More

    Hypercalcemia remains an adverse prognostic factor for newly diagnosed multiple myeloma patients in the era of novel anti-myeloma therapies.
    Eur J Haematol 2017 Jul 4. Epub 2017 Jul 4.
    Greek Myeloma Study Group, Greece.
    Objectives: To evaluate the prognostic impact of hypercalcemia in newly diagnosed patients with symptomatic multiple myeloma (MM), especially after the incorporation of new agents.

    Methods: we analyzed the outcomes of newly diagnosed patients with symptomatic myeloma included in the database of the Greek Myeloma Study Group for the prognostic effect of the presence of hypercalcemia (defined as corrected serum calcium ≥11 mg/dl) at diagnosis.

    Results: Among 2129 consecutive patients with symptomatic MM, 19. Read More

    A Novel Hypokalemic-Alkalotic Salt-Losing Tubulopathy in Patients with CLDN10 Mutations.
    J Am Soc Nephrol 2017 Jul 3. Epub 2017 Jul 3.
    Nephrology, and
    Mice lacking distal tubular expression of CLDN10, the gene encoding the tight junction protein Claudin-10, show enhanced paracellular magnesium and calcium permeability and reduced sodium permeability in the thick ascending limb (TAL), leading to a urine concentrating defect. However, the function of renal Claudin-10 in humans remains undetermined. We identified and characterized CLDN10 mutations in two patients with a hypokalemic-alkalotic salt-losing nephropathy. Read More

    Gastric and pulmonary sarcoidosis complicated by hypercalcemia and acute renal failure: Case report and literature review.
    Lung India 2017 Jul-Aug;34(4):380-382
    Department of Pulmonary Medicine, Gastroenterology and Radiology, Fortis Hospital, Bengaluru, Karnataka, India.
    Gastric sarcoidosis is a very rare manifestation of sarcoidosis. Only few case reports have been described in the literature. We present a case of coexisting gastric and pulmonary sarcoidosis in a 56-year-old female, who presented with gastrointestinal symptoms. Read More

    Prevalence of hypercalcemia of malignancy among pediatric cancer patients in the UK Clinical Practice Research Datalink database.
    Clin Epidemiol 2017 15;9:339-343. Epub 2017 Jun 15.
    Center for Observational Research, Amgen Inc., Thousand Oaks and South San Francisco, CA, USA.
    Background: The reported proportion of cancer patients who experience hypercalcemia of malignancy (HCM) is low, particularly in the pediatric population, ranging between <1% and 5%. HCM can be observed with any type of tumor in children and occurs most commonly with leukemia. While HCM is a potentially fatal condition, the prevalence of HCM is not well understood in pediatric cancer patients. Read More

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