158,692 results match your criteria Military Medicine[Journal]


Posttraumatic Headache.

Authors:
Brigid Dwyer

Semin Neurol 2018 Dec 6;38(6):619-626. Epub 2018 Dec 6.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.

Posttraumatic headaches are among the most challenging complaints after mild traumatic brain injury (mTBI). They are a debilitating problem experienced by patients after TBI of all severities. Up to 90% of mild TBI patients experience headache, particularly if female and with a premorbid history of primary headache. Read More

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December 2018
3 Reads

High Circulating Alarin Levels Are Associated with Presence of Metabolic Syndrome.

Cell Physiol Biochem 2018 Dec 6;51(5):2041-2051. Epub 2018 Dec 6.

Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University and Chongqing Clinical Research Center for Geriatrics, Chongqing,

Background/aims: Alarin has been reported to be related with increased food intake and body weight. The relationship of circulating Alarin with insulin resistance or metabolic syndrome (MetS), however, is unknown. This study aimed to investigate the physiological role of Alarin and its association with MetS in humans. Read More

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December 2018
1 Read

Case report: Disseminated pulmonary mucormycosis involving spleen in diabetic patient with aggressive surgical approach.

Int J Surg Case Rep 2018 Nov 29;54:42-46. Epub 2018 Nov 29.

Department of General Surgery, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Introduction: Mucormycosis is a life threatening fungal infection that occurs in immunocompromised patients.

Presentation Of Case: A 36-year-old Saudi male with known case of Insulin-Dependent Diabetes Mellitus (IDDM), who was presented with productive cough and diarrhea. Computed tomography (CT) revealed a disseminated fungal invasion of the lungs and spleen with invading the fundus of the stomach. Read More

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November 2018

The prevalence and prognostic value of myelin oligodendrocyte glycoprotein antibody in adult optic neuritis.

J Neurol Sci 2018 Nov 28;396:225-231. Epub 2018 Nov 28.

Department of Ophthalmology, Military General Hospital of Beijing PLA, Beijing, China. Electronic address:

Background And Objective: Adult demyelinating optic neuritis (ON) with positive myelin-oligodendrocyte glycoprotein antibody (MOG-Ab) has distinct clinical features. This study aimed to investigate the point prevalence, relationship with steroid dependency and prognosis value of MOG-Ab in adult ON.

Methods: Clinical data analysis was undertaken in adults with ON admitted between December 2014 and January 2016. Read More

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November 2018
1 Read

Wuzhi capsule (Schisandra Sphenanthera extract) attenuates liver steatosis and inflammation during non-alcoholic fatty liver disease development.

Biomed Pharmacother 2018 Dec 3;110:285-293. Epub 2018 Dec 3.

Department of Organ Transplantation, ChangZheng Hospital, Second Military Medical University, Shanghai, 200003, China. Electronic address:

Objective: Wuzhi (WZ) capsule contains an ethanol extract of Schisandra sphenanthera. The efficacy of WZ in treating non-alcoholic fatty liver disease (NAFLD) has not yet been elucidated. The present study assessed the effects of WZ on NAFLD. Read More

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December 2018
2 Reads
2.023 Impact Factor

Proteomic analysis of olfactory bulb suggests CACNA1E as a promoter of CREB signaling in microbiota-induced depression.

J Proteomics 2018 Dec 3. Epub 2018 Dec 3.

Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China; Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China. Electronic address:

Major depressive disorders impact approximately 17% of the population worldwide, whose high morbidity and considerable adversity have resulted in enormous social and economic burden. In addition, clinically depressed patients often show reduced volume of olfactory bulb (OB) and decreased olfactory sensitivity. Although mounting evidence conveyed that the gut microbiota may implicate the pathophysiology of major depressive disorder (MDD) via the microbe-gut-brain axis, knowledge about its distinctive molecular mechanism is rudimentary. Read More

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December 2018
2 Reads

Liver transplantation in patients with liver failure related to exertional heatstroke.

J Hepatol 2018 Dec 3. Epub 2018 Dec 3.

AP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, Liver Intensive Care Unit, Villejuif, F-94800, France; INSERM, Unité 1193, Université Paris-Saclay, Villejuif, F-94800, France; DHU Hepatinov, Villejuif, F-94800, France.

Severe acute liver injury (sALI) is a grave complication of exertional heatstroke (EH). Liver transplantation (LT) may be a therapeutic option, but the criteria for, and timing of transplantation have not been clearly established. The aim of this study was to define the profile of patients who require transplantation in this context. Read More

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December 2018
3 Reads

Socioeconomic disparities in a population of patients undergoing total thyroidectomy for benign disease.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California.

Background: This study examines the effect of insurance status (as a measure of socioeconomic status) on patient with benign thyroid disease.

Methods: A retrospective review was performed among 60 patients undergoing total thyroidectomy for benign thyroid disease. Univariate and multivariable analyses examined the relationship between insurance status and thyroid volume (sum of the left and right lobe volumes). Read More

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December 2018

Effects of acute exposures of 2,4,6-trinitrotoluene and inorganic lead on the fecal microbiome of the green anole (Anolis carolinensis).

PLoS One 2018 6;13(12):e0208281. Epub 2018 Dec 6.

The Environmental Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, Mississippi, United States of America.

Microbiome studies focused on ecologically relevant vertebrate models like reptiles have been limited. Because of their relatively small home range, fast maturation, and high fecundity, lizards are an excellent reptilian terrestrial indicator species. For this study we used the green anole, Anolis carolinensis, to assess the impact of military relevant contaminants on fecal microbiome composition. Read More

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December 2018
1 Read

Does perceived ostracism contribute to mental health concerns among veterans who have been deployed?

PLoS One 2018 6;13(12):e0208438. Epub 2018 Dec 6.

Department of Psychology, Illinois State University, Normal, Illinois, United States of America.

Posttraumatic stress-negative psychological experiences as a result of traumatic stressors-can hinder military veterans' reintegration into society and cause various mental health problems. Veterans need quality social relationships to facilitate reintegration and to cope with posttraumatic stress and related mental health problems; discrimination or other forms of interpersonal rejection can exacerbate these veterans' problems. Ostracism (i. Read More

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December 2018

An evaluation roadmap for critical quality attributes from tier 1 in analytical similarity assessment.

PLoS One 2018 6;13(12):e0208354. Epub 2018 Dec 6.

Department of Health Statistics, Fourth Military Medical University, Xi'an, Shannxi, China.

Analytical similarity assessment of critical quality attributes (CQAs) serves as a foundation for the development of biosimilar products and facilitates an abbreviated subsequent clinical evaluation. In this study, we establish a statistical evaluation roadmap with statistical approaches for some selected CQAs from Tier 1, because they are most relevant to clinical outcomes and require the most rigorous statistical methods. In the roadmap, we incorporate 3 methods-ranking and tier assignment of quality attributes, the equivalence test, and the Mann-Whitney test for equivalence-that are important to determine analytical similarity between the reference and biosimilar products. Read More

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December 2018
1 Read

Evaluation of the effectiveness of laser photoselective vaporization of the prostate in the treatment of patients with benign prostatic hyperplasia.

Folia Med Cracov 2018 ;58(3):23-33

Urology Department Military Institute of Medicine, Szaserów 128, Warszawa, Poland.

Introduction: The prolongation of the life of men results in the growing number of people suffering from benign prostatic hyperplasia (BPH). In 2010, BPH concerned more than 200 million men in the whole world, which at that time made up 6% of the population of men at large. Currently, the population of men in the world amounts about three billion six hundred million. Read More

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January 2018
2 Reads

Laparoscopic sleeve gastrectomy and gastroesophageal reflux.

Rom J Intern Med 2018 Dec;56(4):227-232

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

The prevalence of obesity is rising, becoming a medical problem worldwide. Also GERD incidence is higher in obese patients compared with normal weight, with an increased risk of 2.5 of developing symptoms and erosive esophagitis. Read More

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December 2018

microRNA-129-5p is regulated by choline availability and controls EGF receptor synthesis and neurogenesis in the cerebral cortex.

FASEB J 2018 Dec 6:fj201801094RR. Epub 2018 Dec 6.

Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.

Choline availability modulates neurogenesis and cerebral cortex development through the regulation of neural progenitor cell (NPC) proliferative and differentiation capacity. In this study, we demonstrated that cortical NPC self-renewal is controlled by choline via the expression of a microRNA (miR-129-5p), whose role in the developing brain has not been examined, and which, in turn, inhibits synthesis of the epidermal growth factor receptor (EGFR) protein. Specifically, we found that low choline (LC) availability led to the upregulation of miR-129-5p expression in cortical NPCs in vitro and in vivo, causing the downregulation of EGFR and thereby disrupting NPC self-renewal and cortical neurogenesis. Read More

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December 2018

APOE-ε4 Genotype is Associated with Elevated Post-Concussion Symptoms in Military Veterans with a Remote History of Mild Traumatic Brain Injury.

Arch Clin Neuropsychol 2018 Dec 6. Epub 2018 Dec 6.

VA San Diego Healthcare System (VASDHS); San Diego, CA, USA.

Objective: We evaluated the influence of the APOE-ε4 allele on post-concussive symptoms in military Veterans with a remote history of mild traumatic brain injury (mTBI).

Method: Participants (N = 77) were administered neuropsychiatric measures, on average, approximately 5 years following their most recent mTBI and provided a DNA sample for APOE genotyping. Veterans were divided into two groups based on their ε4 status (n = 14 ε4+, n = 63 ε4-). Read More

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December 2018
2 Reads

Short communication: switching immunosuppression from cyclosporine to tacrolimus in kidney transplant recipients based on CYP3A5 genotyping.

Ther Drug Monit 2018 Dec 4. Epub 2018 Dec 4.

Department of Pharmacy, Shanghai Changhai Hospital, Second Military Medical University, Shanghai (200433), China.

Background: Kidney transplant recipients on long-term cyclosporine (CsA) therapy may develop multiple adverse drug events, and immunosuppression conversion from CsA to tacrolimus (Tac) is an option. Genetic variations, especially cytochrome P450 (CYP) 3A5*3 affects Tac dosing. However, little information is available to guide the conversion with regards to patients' pharmacogenomics. Read More

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December 2018
1 Read

Ketamine-induced anaphylactic shock during elective parotidectomy: A case report.

Eur J Anaesthesiol 2019 Jan;36(1):70-71

From the Department of Anaesthesiology and Intensive Care (QM, JB, PEG), Department of Pulmonology (NP), Department of Otorhinolaryngology, Military Hospital Sainte Anne, Toulon (LV) and French Military Health Service Academy Unit, Ecole du Val-de-Grâce, Paris, France (JB).

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January 2019

War against respiratory syncytial virus. An 8-year experience at a tertiary hospital.

Authors:
Adel S Al Harbi

Saudi Med J 2018 Dec;39(12):1200-1206

Department of Pediatric Pulmonary Medicine, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To assess the respiratory syncytial virus (RSV) infection incidence rate through the analysis of data collected before and after implementation of a new palivizumab dosing regimen customized for a high-risk Saudi population. Methods: This was a retrospective cohort study performed at Prince Sultan Military Medical City, Riyadh, Saudi Arabia between November 2009 and April 2017 on 1704 high risk Saudi young children and comparing 3 palivizumab regimens: a 4-week interval dosing regimen starting in either November or mid-September and a 3-week interval dosing regimen starting in mid-September. Results: Despite a decrease in the incidence rate of RSV infection with the three-week interval regimen (3. Read More

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December 2018

Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Xijing Hospital, Air Force Military Medical University (Fourth Military Medical University); Xi'an-China.

Objective: To investigate the expression profile of circular RNAs (circRNAs) and proposed circRNA-microRNA (miRNA) regulatory network in atrial fibrillation (AF).

Methods: Atrial tissues from patients with persistent AF with rheumatic heart disease and non-AF myocardium with normal hearts were collected for circRNA differential expression analyses by high-throughput sequencing. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to predict the potential functions of the differentially expressed genes and AF-related pathways. Read More

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December 2018

Potential of Exosomes for the Treatment of Stroke.

Cell Transplant 2018 Dec 6:963689718816990. Epub 2018 Dec 6.

1 Department of Anatomy, Histology and Embryology, Discipline of Neuroscience, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Stroke is the result of blockage or rupture of blood vessels in the brain and is the leading cause of death and disability in the world. Currently only a very limited number of therapeutic approaches are available for treatment of stroke patients, and the vast majority of neuroprotective agents that tested positively in pre-clinical studies failed in clinical trials. In recent years, the clinical value of the use of exosomes for stroke treatment has received widespread attention due their unique characteristics such as low immunogenicity, low toxicity and biodegradability, ability to cross the blood-brain barrier (BBB), and their important role in communication between cells. Read More

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December 2018
1 Read

Improvements in Lipid Suppression for 1H NMR-based Metabolomics: Applications to Solution-state and HR-MAS NMR-natural and in vivo samples.

Magn Reson Chem 2018 Dec 5. Epub 2018 Dec 5.

Environmental NMR Centre, Dept. of Physical and Environmental Sciences, University of Toronto, Scarborough, 1265 Military Trail, Toronto, ON, Canada, M1C 1A4.

Proton NMR spectra of intact biological samples often show strong contributions from lipids which overlap with signals of interest from small metabolites. Pioneering work by Diserens et al. demonstrated that the relative differences in diffusivity and relaxation of lipids verses small metabolites could be exploited to suppress lipid signals, in HR-MAS NMR spectroscopy. Read More

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December 2018
1 Read

Hsa-miRNA-29a protects against high glucose-induced damage in human umbilical vein endothelial cells.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Sustained exposure to high glucose (HG) results in dysfunction of vascular endothelial cells. Hence, diabetic patients often suffer from secondary vascular damages, such as vascular sclerosis and thrombogenesis, which may eventually cause cardiovascular problems. Thus, elucidating how HG results in vascular endothelial cell damage and finding an approach for prevention are important to prevent and treat vascular damages in diabetic patients. Read More

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December 2018

Chinese society of cardiology expert consensus statement on the diagnosis and treatment of adult fulminant myocarditis.

Sci China Life Sci 2018 Dec 3. Epub 2018 Dec 3.

Department of Cardiology, Changzheng Hospital, The Second Military Medical University, Shanghai, 200003, China.

Fulminant myocarditis is primarily caused by infection with any number of a variety of viruses. It arises quickly, progresses rapidly, and may lead to severe heart failure or circulatory failure presenting as rapid-onset hypotension and cardiogenic shock, with mortality rates as high as 50%-70%. Most importantly, there are no treatment options, guidelines or an expert consensus statement. Read More

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December 2018
2 Reads

Development of a reverse genetics system for a feline panleukopenia virus.

Virus Genes 2018 Dec 5. Epub 2018 Dec 5.

Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Science, 666 Liuying Xi Road, Changchun, 130122, China.

Feline panleukopenia virus (FPV) infects cats and can be fatal to kittens. There is evidence that canine parvovirus originated from FPV, which makes FPV important in studies of the family Parvoviridae. In the present study, the entire genome of FPV strain HH-1/86 was converted into a full-length infectious clone (pFPV). Read More

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December 2018
1 Read

Neuroprotective Autophagic Flux Induced by Hyperbaric Oxygen Preconditioning is Mediated by Cystatin C.

Neurosci Bull 2018 Dec 5. Epub 2018 Dec 5.

Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.

We have previously reported that Cystatin C (CysC) is a pivotal mediator in the neuroprotection induced by hyperbaric oxygen (HBO) preconditioning; however, the underlying mechanism and how CysC changes after stroke are not clear. In the present study, we demonstrated that CysC expression was elevated as early as 3 h after reperfusion, and this was further enhanced by HBO preconditioning. Concurrently, LC3-II and Beclin-1, two positive-markers for autophagy induction, exhibited increases similar to CysC, while knockdown of CysC blocked these elevations. Read More

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December 2018
2 Reads

Forced-Air Warming and Resistive Heating Devices. Updated Perspectives on Safety and Surgical Site Infections.

Front Surg 2018 21;5:64. Epub 2018 Nov 21.

Department of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.

Perioperative hypothermia is one of the most common phenomena seen among surgical patients, leading to numerous adverse outcomes such as intraoperative blood loss, cardiac events, coagulopathy, increased hospital stay and associated costs. Forced air warming (FAW) and resistive heating (RH) are the two most commonly used and widely studied devices to prevent perioperative hypothermia. The effect of FAW on operating room laminar flow and surgical site infection is unclear and we initiated an extensive literature search in order to get a scientific insight of this aspect. Read More

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November 2018

Portal Hypertension.

Can J Gastroenterol Hepatol 2018 4;2018:1289156. Epub 2018 Nov 4.

Medicina Interna 1, ARNAS-Civico, Di Cristina-Benfratelli, Palermo, Italy.

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November 2018

Polymorphisms Contribute to Hepatocellular Carcinoma Susceptibility in Chinese Population with Liver Cirrhosis: A Case-Control Study.

J Cancer 2018 20;9(22):4294-4300. Epub 2018 Oct 20.

Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

Single nucleotide variations in the liver fatty acid binding protein () gene lead to changes in cellular signaling pathways and lipid metabolism. polymorphisms were associated with some liver diseases, like steatotic hepatocellular carcinoma. However, the association between rs1545224 and rs2241883 polymorphisms and hepatitis B virus-related liver cirrhosis (LC) and hepatocellular carcinoma (HCC) has not been reported. Read More

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October 2018
1 Read

A Nomogram Predicting Extrahepatic Metastases for Patients with Adjuvant Transarterial Chemoembolization after Hepatectomy.

J Cancer 2018 20;9(22):4223-4233. Epub 2018 Oct 20.

Department of Laboratory Medicine, Third Affiliated Hospital of Second Military Medical University, Shanghai, China.

Prognosis remains poor for hepatocellular carcinoma (HCC) patients with extrahepatic metastases (EHMs). This study aimed to develop a nomogram to predict EHMs in HCC patients who underwent adjuvant transarterial chemoembolization (TACE) following hepatectomy. Data of 578 HCC patients who underwent TACE after hepatectomy at the Eastern Hepatobiliary Surgery Hospital was retrospectively reviewed. Read More

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October 2018
1 Read

Lung transplantation.

Breathe (Sheff) 2018 Dec;14(4):276-277

Associação de Transplantados Pulmonares de Portugal, Lisbon, Portugal.

I was born in 1959 in Lisbon. My early years were marked by a typical family life, and we travelled a lot because of my father's work. I completed my schooling until the 12th grade and then started to work. Read More

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December 2018
1 Read

Zishenwan Decreases Kidney Damage in Recurrent Urinary Tract Infection through the Inhibition of Toll-Like Receptor 4 Signal.

Evid Based Complement Alternat Med 2018 5;2018:5968657. Epub 2018 Nov 5.

Suzhou Academy of Wumen Chinese Medicine, Suzhou 215000, China.

Objectives: To investigate the mechanism of the protective effect of Zishenwan on pyelonephritis rats.

Methods: In the rat model of pyelonephritis, protective effects of Zishenwan, the content of secretory immunoglobulin A (SIg A), and interleukins were detected by ELISA. The expressions of TLR4-NFB pathway were detected by Western blot in renal and urinary tract mucosa. Read More

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November 2018
1 Read

Development and Application of an UHPLC-MS/MS Method for Comparative Pharmacokinetic Study of Eight Major Bioactive Components from Yin Chen Hao Tang in Normal and Acute Liver Injured Rats.

Evid Based Complement Alternat Med 2018 1;2018:3239785. Epub 2018 Nov 1.

School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai 200433, China.

Yin Chen Hao Tang (YCHT) is one of the most famous hepatoprotective herbal formulas in China, but its pharmacokinetic investigation in model rats has been rarely conducted. In this study, the hepatic injury model was caused by intraperitoneal injections of carbon tetrachloride (CCl), and YCHT was orally administered to the model and normal rats. An ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was established to analyze the plasma pharmacokinetics of eight major bioactive ingredients from YCHT in both the normal and liver injured rats. Read More

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November 2018

Posttraumatic Stress Disorder Symptom Network Analysis in U.S. Military Veterans: Examining the Impact of Combat Exposure.

Front Psychiatry 2018 20;9:608. Epub 2018 Nov 20.

Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, United States.

Recent work inspired by graph theory has begun to conceptualize mental disorders as networks of interacting symptoms. Posttraumatic stress disorder (PTSD) symptom networks have been investigated in clinical samples meeting full diagnostic criteria, including military veterans, natural disaster survivors, civilian survivors of war, and child sexual abuse survivors. Despite reliable associations across reported networks, more work is needed to compare central symptoms across trauma types. Read More

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November 2018
2 Reads

Urinary schistosomiasis: report of case diagnosed in bladder biopsy.

BMC Clin Pathol 2018 28;18:13. Epub 2018 Nov 28.

Department of Pathology, Military General Hospital Mohammed V, Mohammed V- Souissi University, Hay Riad, 10000 Rabat, Morocco.

Background: Urinary schistosomiasis is a common parasitic disease in endemic countries.

Case Presentation: We report the case of a patient who was on a working trip to Mauritania. This parasitosis, suspected in the presence of hematuria and the notion of stay in an endemic zone, was confirmed by the presence of Schistosoma heamatobium eggs during the histological examination of the bladder biopsy performed after cystoscopy, highlighting a bilharzial granuloma and of course, the diagnosis was confirmed by the presence of eggs during the direct examination of the freshly collected urine. Read More

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November 2018

CREPT/RPRD1B associates with Aurora B to regulate Cyclin B1 expression for accelerating the G2/M transition in gastric cancer.

Cell Death Dis 2018 Dec 5;9(12):1172. Epub 2018 Dec 5.

State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, 100084, China.

Gastric cancer, like most of other cancers, has an uncontrolled cell cycle regulated by cyclins and cyclin-dependent kinases (CDKs). In this study, we reported that gastric cancer cells showed an accelerated G2/M transition promoted by CREPT/RPRD1B and Aurora kinase B (Aurora B). We found that CREPT/RPRD1B and Aurora B were coordinately expressed during the cell cycle in gastric cancer cells. Read More

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December 2018
3 Reads
5.014 Impact Factor

A systematic review and network meta-analysis of the comparative efficacy of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in hypertension.

J Hum Hypertens 2018 Dec 5. Epub 2018 Dec 5.

3rd Department of Internal Medicine, Hypertension-24h Ambulatory Blood Pressure Monitoring Center, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are drugs commonly used for the treatment of hypertension. However, studies on their comparative efficacy have not been extensively investigated. The current systematic review and network meta-analysis studied the comparative efficacy of the two antihypertensive treatment categories in reducing blood pressure, mortality, and morbidity in essential hypertension patients. Read More

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December 2018

Patient safety after implementation of a coproduced family centered communication programme: multicenter before and after intervention study.

BMJ 2018 Dec 5;363:k4764. Epub 2018 Dec 5.

Harvard Medical School, Boston, MA, USA.

Objective: To determine whether medical errors, family experience, and communication processes improved after implementation of an intervention to standardize the structure of healthcare provider-family communication on family centered rounds.

Design: Prospective, multicenter before and after intervention study.

Setting: Pediatric inpatient units in seven North American hospitals, 17 December 2014 to 3 January 2017. Read More

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December 2018

Assessment of chiropractic care on strength, balance, and endurance in active-duty U.S. military personnel with low back pain: a protocol for a randomized controlled trial.

Trials 2018 Dec 5;19(1):671. Epub 2018 Dec 5.

The Spine Institute for Quality, 102 2nd Street, Davenport, IA, 52801,, USA.

Background: Low back pain (LBP) is a common cause of disability among U.S. military personnel. Read More

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December 2018

Cognitive function in adolescence and the risk for premature diabetes and cardiovascular mortality in adulthood.

Cardiovasc Diabetol 2018 Dec 5;17(1):154. Epub 2018 Dec 5.

The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Epidemiological studies have demonstrated a relationship between cognitive function in youth and the future risk of death. Less is known regarding the relationship with diabetes related death. This study assessed the relationship between cognitive function in late adolescence and the risk for diabetes, cardiovascular- (CVD) and all-cause mortality in adulthood. Read More

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December 2018
2 Reads

Risk factor for steatorrhea in pediatric chronic pancreatitis patients.

BMC Gastroenterol 2018 Dec 5;18(1):182. Epub 2018 Dec 5.

Department of Gastroenterology, Gongli Hospital, The Second Military Medical University, Shanghai, China.

Background: Pediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best knowledge, there is no pediatric study to document the natural history of steatorrhea in CP. Read More

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December 2018

Ultrasonic assessment of liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis.

BMC Gastroenterol 2018 Dec 5;18(1):181. Epub 2018 Dec 5.

Department of Ultrasound Diagnosis, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi Province, China.

Background: This study investigated the relationship between liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis. We used an acoustic radiation force impulse (ARFI) technique to measure stiffness, and a radio frequency (RF) vascular quantitative ultrasound technique to measure changes in common carotid artery elasticity and vascular function.

Methods: Two-hundred seventeen patients with chronic viral hepatitis caused by either hepatitis B virus (HBV) or hepatitis C virus (HCV) were enrolled. Read More

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December 2018

Forced oscillation technique in veterans with preserved spirometry and chronic respiratory symptoms.

Respir Physiol Neurobiol 2018 Nov 30. Epub 2018 Nov 30.

Airborne Hazards Center of Excellence, War Related Illness and Injury Study Center, Veterans Affairs New Jersey Health Care System, East Orange, NJ, USA; New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, NJ, USA. Electronic address:

Purpose: To evaluate the utility of the forced oscillation technique (FOT) among military veterans with preserved spirometry and chronic unexplained respiratory symptoms.

Methods: 178 veterans referred for evaluation of unexplained respiratory symptoms completed pulmonary function testing and FOT. Preserved spirometry was defined as FEV/FVC, FEV and FVC ≥ 5 percentile. Read More

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November 2018

Thyrotropin receptor antibody: A novel risk indicator for pregnancy loss.

Clin Biochem 2018 Nov 30. Epub 2018 Nov 30.

Department of Transfusion Medicine, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China. Electronic address:

Background: Thyroid autoantibody has been associated with adverse pregnancy outcomes. However, thyroid-receptor antibody (TRAb) has not been considered as a potential risk assessment indicator for adverse pregnancy outcomes. Therefore, we assessed the role of TRAb in evaluation of the risk of adverse pregnancy outcomes. Read More

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November 2018

Dissociative effects of dorsomedial striatum D1 and D2 receptor antagonism in the regulation of anxiety and learned approach-avoidance conflict decision-making.

Neuropharmacology 2018 Nov 30. Epub 2018 Nov 30.

Department of Psychology, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON, M1C 1A4, Canada. Electronic address:

The dorsal striatum is traditionally known for its role in sensorimotor integration. However, the dorsomedial striatum (DMS) has also been implicated in cost-benefit conflict processing, a role more readily attributed to the ventral striatum (VS), as a site of limbic-motor integration. We recently showed that dopaminergic D1 (D1R) and D2 receptors (D2R) in the VS exert dissociable control over cue-elicited approach-avoidance decision-making, in the presence of conflicting motivational stimuli. Read More

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November 2018

Overlooked Implications of Disturbed Sleep in Traumatic Brain Injury.

JAMA Neurol 2018 Dec 3. Epub 2018 Dec 3.

San Antonio Military Health System, Department of Sleep Medicine, JBSA Lackland, Texas.

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December 2018