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Respir Med Case Rep 2019 23;26:236-239. Epub 2019 Jan 23.

Infectious Diseases Unit, Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia.

Mycotic tuberculous aneurysm is extremely rare. The aorta is the main affected artery however; iliac and less commonly femoral arteries can also be affected. In 75% of the cases a contagious focus leads to infection through erosion of the vessel wall; on the other hand direct seeding of the blood vessel wall via the vasa vasorum may occur in 25%. Read More

PLoS One 2019 15;14(2):e0211972. Epub 2019 Feb 15.

Field Service, National Infection Service, Public Health England, London, United Kingdom.

Recurrence of TB in an individual can occur due to relapse of the same strain or reinfection by a different strain. The contribution of reinfection and relapse to TB incidence, and the factors associated with each are unknown. We aimed to quantify and describe cases attributable to relapse or reinfection, and identify associated risk factors in order to reduce recurrence. Read More

Clin Exp Emerg Med 2019 Feb 12. Epub 2019 Feb 12.

Department of Emergency Medicine, Chungbuk National University Hospital, Cheongju, Korea.

Perihepatic capsulitis is associated with various diseases, such as Fitz-Hugh-Curtis syndrome, systemic lupus erythematosus, perforated cholecystitis, perforated hepatic abscess, and tuberculous peritonitis. Miliary tuberculosis is present in about 2% of all reported cases of tuberculosis and is characterized by the widespread millet-like hematogenous dissemination of Mycobacterium tuberculosis. We describe a 24-year-old virgin patient presenting with right upper quadrant and costovertebral angle pain. Read More

Arch Soc Esp Oftalmol 2019 Feb 1. Epub 2019 Feb 1.

Servicio de Medicina Interna, Hospital Universitario 12 de Octubre, Madrid, España.

A 57-year-old man with miliary tuberculosis reported visual loss in his right eye, a month after starting a four-drug antituberculous treatment regimen. On exploration, an inferior segmental optic disc edema was objectived and it was attributed to ischemic aetiology. Ethambutol was withdrawn and 60mg of oral prednisone daily were given with a tapering dosage. Read More

Int J Tuberc Lung Dis 2019 Jan 24. Epub 2019 Jan 24.

Medecine Unit, Hôpital médico-chirurgical militaire Bouffard, Djibouti City, Djibouti.

SUMMARY

GE Port J Gastroenterol 2018 Dec 13;26(1):64-69. Epub 2018 Mar 13.

Gastroenterology Department of Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.

Tumor necrosis factor alpha (TNFα) antagonist is recognized as an effective treatment to achieve clinical remission and healing mucosal in patients with moderate to severe active Crohn's disease. Considering that it plays a central role in immune-mediated modulation, there are some obvious concerns about its long-term safety. There is evidence that it may increase the risk of opportunistic infections such as tuberculosis, particularly reactivation of previous latent infection. Read More

Respir Med Case Rep 2019 5;26:165-167. Epub 2019 Jan 5.

Landspitali University Hospital, Department of Anaesthesia and Intensive Care, Hringbraut, 101, Reykjavik, Iceland.

Tuberculosis is a rare cause of (ARDS) and mortality rates are high in tuberculosis patients that need treatment with mechanical ventilation. Experience of the use of (ECMO) in such circumstances is scarce. We report the case of an 18 year old man where prolonged therapy (50 days) with (ECMO) allowed extensive lung damage from miliary tuberculosis to heal. Read More

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine. Electronic address:

Background: Miliary nodules have been typically described as a radiological manifestation of disseminated tuberculosis. However, miliary nodules are known to occur in a wide variety of conditions. The primary objective of the study was to identify clinical characteristics and etiologies of miliary nodules within our institution. Read More

Int J Tuberc Lung Dis 2019 Jan 8. Epub 2019 Jan 8.

Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang City, Liaoning Province, China.

OBJECTIVE:

METHODS:

RESULTS:

Int J Tuberc Lung Dis 2018 Dec;22(12):1495-1504

National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Objective: To estimate the number and cost of hospitalizations with a diagnosis of active tuberculosis (TB) disease in the United States.

Methods: We analyzed the 2014 National In-Patient Sample using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9) codes to identify hospitalizations with a principal (TB-PD) or any secondary discharge (TB-SD) TB diagnosis. We used a generalized linear model with log link and gamma distribution to estimate the cost per TB-PD and TB-SD episode adjusted for patient demographics, insurer, clinical elements, and hospital characteristics. Read More

BMJ Case Rep 2018 Dec 4;11(1). Epub 2018 Dec 4.

Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.

Tumour necrosis factor-alpha (TNF-α) is a key proinflammatory cytokine in non-infective uveitis (NIU). Adalimumab, an anti-TNF-α monoclonal antibody, is approved for the treatment of severe NIU by the European Medicines Agency. There is a recognised risk of serious infections, including tuberculosis (TB), during anti-TNF-α therapy in systemic immune-mediated diseases. Read More

Acta Radiol Open 2018 Dec 11;7(12):2058460118817918. Epub 2018 Dec 11.

Department of Radiology, Teikyo University School of Medicine, Tokyo, Japan.

Cerebral tuberculosis (TB) presents most frequently as meningitis in the basilar cistern; however, it can also manifest in various other ways, such as localized encephalitis, abscess, and tuberculoma. Here, focusing on imaging findings, we report an immunocompetent case who demonstrated multiple parenchymal lesions and was diagnosed with cerebral TB after testing positive on QuantiFERON (QTF); her clinical signs/symptoms and laboratory findings responded well to anti-TB medication therapy. The patient was a 60-year-old woman with the chief complaints of headache and consciousness disturbance. Read More

J Neurol Sci 2019 Feb 7;397:11-15. Epub 2018 Dec 7.

Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.

Objective: Computed tomography (CT) of the thorax is the imaging modality of choice to detect or demonstrate lesions suggestive of active pulmonary tuberculosis. We aimed to evaluate the imaging abnormalities detected on CT of the thorax in patients with tuberculous meningitis (TBM).

Methods: In this prospective study, we enrolled consecutive newly-diagnosed patients with TBM. Read More

Arch Dis Child Educ Pract Ed 2018 Nov 15. Epub 2018 Nov 15.

Department of Paediatric Neurology, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.

Differentiated thyroid cancer is a rare disease in children and adolescents and manifests exclusively in the form of papillary thyroid cancer (PTC). We present a rare case of PTC who presented initially with lung symptoms and miliary nodules on chest X-ray. This case emphasises the important differential of miliary mottling of the lungs. Read More

Praxis (Bern 1994) 2018 Nov;107(23):1279-1282

3 Emergency Dpt, St Francis Referral Hospital and Ifakara Health Institute, Ifakara, Tanzania.

Point-of-Care Ultrasound: Teaching and Learning in Ifakara, Tanzania Abstract. Presentation of two practical cases from the point-of-care ultrasound class in Ifakara, Tanzania. The first case shows the sonographic findings of tuberculosis with findings in the lungs, heart, abdominal lymph nodes and spleen. Read More

Clin Microbiol Infect 2018 Oct 27. Epub 2018 Oct 27.

University of Groningen, Groningen Research Institute of Pharmacy, Unit of Pharmaco-Therapy, Epidemiology and -Economics (PTE2), the Netherlands.

Objectives: We evaluated treatment outcomes and predictors for poor treatment outcomes for tuberculosis (TB) among native- and foreign-born patients with drug-susceptible TB (DSTB) in the Netherlands.

Methods: This retrospective cohort study included adult patients with DSTB treated from 2005 to 2015 from a nationwide exhaustive registry. Predictors for unsuccessful treatment outcomes (default and failure) and TB-associated mortality were analysed using multivariate logistic regression. Read More

Int J Dermatol 2019 Feb 1;58(2):e29-e30. Epub 2018 Nov 1.

Department of Dermatology and Sexually Transmitted Diseases, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

J Clin Med 2018 Oct 29;7(11). Epub 2018 Oct 29.

Discipline of Paediatrics and Adolescent Medicine, The Children's Hospital at Westmead, The University of Sydney, Westmead 2145, Australia.

A 5-month-old boy presented with a focal seizure. Disseminated (miliary) tuberculosis (TB) was diagnosed on chest radiograph and TB meningitis was confirmed using Xpert MTB/RIF. The case represents the first instance of cerebrospinal fluid Xpert MTB/RIF testing in children in central Viet Nam. Read More

Pan Afr Med J 2018 13;30:121. Epub 2018 Jun 13.

Katutura State Hospital, UNAM School of Medicine, Windhoek, Namibia.

Tuberculosis is still one of the most common respiratory diseases in Africa and worldwide and miliary tuberculosis is a regular manifestation of it. Idiopathic pulmonary hemosiderosis is a rare disease entity, presenting in children as well as adults. It is characterized by the triad of recurrent episodes of alveolar hemorrhage, presenting as hemoptysis, iron deficiency anemia and bilateral pulmonary infiltrates seen on chest X-ray. Read More

Expert Rev Anti Infect Ther 2018 Nov;16(11):813-831

a Department of Neurology , King George Medical University , Lucknow , India.

Introduction: Drug-resistant tuberculous meningitis has been reported worldwide. Isoniazid mono-resistance is the most frequent cause of drug-resistant tuberculous meningitis, a life-threatening disease. Extensive drug-resistant tuberculous meningitis has also been reported in some isolated case reports. Read More

JMM Case Rep 2018 Aug 20;5(8):e005164. Epub 2018 Aug 20.

Department of Infectious Diseases, Nottingham University Hospitals City Campus, Nottingham NG5 1PB, UK.

Introduction: Guillain Barré Syndrome (GBS) has rarely been associated with tuberculosis and has been previously reported after Bacille Calmette Guérin (BCG) vaccination, but we report an association of GBS with intra-vesical BCG instillations followed by the clinical picture of disseminated BCGosis.

Case Presentation: A 68-year-old man with bladder carcinoma had a transurethral tumour resection followed by repeated BCG instillations. Catheterization for his eighth dose was traumatic, causing frank haematuria. Read More

Rev Mal Respir 2018 11 11;35(9):989-991. Epub 2018 Oct 11.

Service de pneumologie, grand hôpital de Charleroi, 6, rue Marguerite-Depasse, 6060 Gilly, Belgique. Electronic address:

Respir Med Case Rep 2018 2;25:239-241. Epub 2018 Oct 2.

Penn Medicine-Princeton Medical Center Intensive Care Unit Department, 1 Plainsboro Road, Plainsboro, NJ 08536, USA.

Background: Disseminated tuberculosis (TB) or miliary TB is defined as lymphohematogenous dissemination of bacilli, which may then affect virtually any organ system. The multiple organ involvement in disseminated TB can mimic metastatic cancer and can make the diagnosis challenging. False negatives are common therefore repeating microbiologic and histologic samples is essential. Read More

Forensic Sci Med Pathol 2019 Mar 6;15(1):151-154. Epub 2018 Oct 6.

Forensic Unit, Department of Pathology, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, Malaysia.

Melioidosis is an infectious disease caused by Burkholderia pseudomallei, a gram-negative intracellular bacillus. Tuberculosis, also an infectious disease, is caused by Mycobacterium tuberculosis, an acid fast bacillus. In both diseases, patients commonly present with fever and respiratory symptoms due to sepsis which might lead to respiratory failure or sudden death if left untreated. Read More

BMJ Case Rep 2018 Oct 2;2018. Epub 2018 Oct 2.

Internal Medicine, Cooper University Hospital, Camden, New Jersey, USA.

The use of biologic drugs has expanded since its introduction in the late 1990s. With growing medical use and newer biologic drugs in development, opportunistic infections like remain important adverse effects. It carries major public health concerns, yet evidence-based clinical guidelines for more routine interval screening in patients taking immunosuppressants and exposed to tuberculosis (TB) are lacking. Read More

AME Case Rep 2018 17;2:36. Epub 2018 Jul 17.

Catholic Health System, Internal Medicine, University at Buffalo, NY, USA.

Dissemination of tuberculosis is known as miliary tuberculosis. The clinical features of disseminated tuberculosis often leads to misdiagnosis. By the time we have bone marrow involvement by tuberculosis, prognosis is really poor. Read More

Lancet 2018 09 24;392(10153):1096-1097. Epub 2018 Sep 24.

Division of Infection and Immunity, Centre for Clinical Microbiology, University College London, London, UK; National Institute of Health Research Biomedical Research Centre at UCL Hospitals, London, UK. Electronic address:

Anaesthesist 2018 Oct 26;67(10):773-779. Epub 2018 Sep 26.

Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Agaplesion Markus Krankenhaus, Wilhelm-Epstein-Str. 4, 60431, Frankfurt, Deutschland.

This article reports the fulminant course of a pneumogenic sepsis with severe ARDS (acute respiratory failure) in a 36-year-old female Indian patient, who died within 14 h after admission to the intensive care unit due to a multiorgan failure. During treatment the diagnosis of a miliary tuberculosis was suspected but was only confirmed by the autopsy. Due to high hygiene standards, miliary tuberculosis as the cause of septic shock is rare in Europe. Read More

Infez Med 2018 Sep;26(3):270-275

Internal Medicine Master of Medicine, Chiclayo, Lambayeque, Peru; Emergency Department of Regional Hospital of Lambayeque, Chiclayo, Lambayeque, Peru.

Central nervous system (CNS) tuberculosis includes three clinical entities: tuberculous meningitis, intracranial tuberculoma, and spinal tuberculous arachnoiditis. All three categories are encountered frequently in regions of the world where the incidence of TB is high. Meningeal tuberculosis is a medical emergency: it is the most severe, lethal and disabling form of tuberculosis. Read More

Infez Med 2018 Sep;26(3):255-262

Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia;Committee on Tropical Medicine, Zoonoses and Travel Medicine, Asociación Colombiana de Infectología (ACIN), Bogotá, DC, Colombia; Medical School, Faculty of Health Sciences, UniFranz, Cochabamba, Bolivia.

Central nervous system (CNS) tuberculosis includes three clinical entities: tuberculous meningitis, intracranial tuberculoma, and spinal tuberculous arachnoiditis. All three categories are encountered frequently in regions of the world where the incidence of TB is high. Meningeal tuberculosis is a medical emergency: it is the most severe, lethal and disabling form of tuberculosis. Read More

Clin Rheumatol 2019 Feb 23;38(2):535-543. Epub 2018 Sep 23.

Department of Rheumatology, the First Affiliated Hospital of Sun Yat-sen University, No 58, Zhongshan Road 2, Guangzhou, 510080, Guangdong, China.

To investigate the characteristics and associated factors for Mycobacterium tuberculosis (TB) infection in patients with systemic lupus erythematosus (SLE) from Southern China. A retrospective study of 1108 patients admitted to the First Affiliated Hospital of Sun Yat-Sen University from January 2007 to December 2017 was performed. Demographic and clinical characteristics, laboratory data, and radiographic manifestations were recorded. Read More

CEN Case Rep 2019 Feb 22;8(1):48-54. Epub 2018 Sep 22.

Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan.

TAFRO syndrome (thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly) is an atypical manifestation of multicentric Castleman's disease. Although overproduction of interleukin-6, vascular endothelial growth factor, and other cytokines may partially explain the pathophysiology of this rare syndrome, the precise mechanisms underlying the renal dysfunction associated with the condition remain unclear. Here, we describe a case of a 69-year-old male with TAFRO syndrome. Read More

Respir Med Case Rep 2018 11;25:216-219. Epub 2018 Sep 11.

Rheumatology Division, PSMMC, Riyadh, Saudi Arabia, P.O. Box 7897, Riyadh, 11159, Saudi Arabia.

A 26-year-old woman was diagnosed with and treated for systemic lupus erythematosus (SLE) in 2002. She was admitted 11 years later with nephrotic-range proteinuria and lupus nephritis and received two doses of rituximab after failing on steroids and mycophenolate mofetil. Four months later, she presented with fever and joint pain/swelling. Read More

Clin J Gastroenterol 2018 Sep 19. Epub 2018 Sep 19.

Department of gastroenterology, Peking University First Hospital, No. 7th, Xishiku Street, Xicheng District, Beijing, 100034, China.

A young patient had serious hematochezia for nearly 2 months without obvious cause. Abdominal CT images showed rare features such as serious hemorrhage and multiple miliary nodules in the small bowel. The colonoscopy showed multiple lymphoid follicles in the terminal ileum. Read More

Int J Mycobacteriol 2018 Jul-Sep;7(3):288-291

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.

Cutaneous tuberculosis (TB) has several clinical manifestations. The most common forms include cervical scrofuloderma and plaque type of lupus vulgaris (LV), otherwise the rare cases including inguinal scrofuloderma, ulcerative LV, and acute miliary TB. The highlight of this case series was to report various rare clinical manifestations of cutaneous TB. Read More

Pathogens 2018 Sep 5;7(3). Epub 2018 Sep 5.

School of Biomedical and Health Sciences, Universidad Europea de Madrid, 28670 Madrid, Spain.

An immunocompetent 82-year-old female was admitted to our hospital due to fever without clear origin and hyponatremia. In the following days, an acute and bilateral pulmonary infiltrate appeared with a progressive worsening in respiratory function. Chest x-ray and CT (Computed tomography) showed bilateral reticulonodular infiltrates. Read More

BMJ Case Rep 2018 Aug 31;2018. Epub 2018 Aug 31.

Department of Medicine, NewYork Presbyterian Hospital/Weill Cornell Medical Center, New York, NY, USA.

We describe the case of a 61-year-old man from the Dominican Republic admitted with diarrhoea, fevers and weight loss who was found to have lab studies and imaging (including radiolabeled somatostatin positron emission tomography/CT scan) initially consistent with a metastatic neuroendocrine tumour. However, after weeks of workup and multiple inconclusive biopsies, he was diagnosed with disseminated extrapulmonary tuberculosis. Here we examine the data for neuroendocrine tumour and tuberculosis labs and imaging to delineate where these studies overlap. Read More

Int J Paleopathol 2018 Aug 14. Epub 2018 Aug 14.

Department of Anthropology, State University of New York at New Paltz, USA.

In 1973, analysis of the mummified remains of a young boy dated to 700AD and from the Late Nasca period (Peru) identified (i) chronic Pott's disease, leading to loss of lower body mobility, and (ii) acute miliary tuberculosis, affecting most organs and the immediate cause of death (Allison et al., 1973). This report was the first to establish, beyond dispute, the presence of tuberculosis in the Americas before the arrival of Europeans. Read More

Int J Gynaecol Obstet 2018 Dec 29;143(3):387-388. Epub 2018 Aug 29.

Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Oman Med J 2018 Jul;33(4):352-355

Department of Internal Medicine, PGIMER, Chandigarh, India.

Tubercular splenic abscess is extremely rare, but are reported commonly in HIV-positive and immunocompromised patients along with miliary or disseminated tuberculosis. Isolated tubercular splenic abscess in an immunocompetent individual is rarely reported. Here we present a case of a young, immunocompetent male with isolated splenic cold abscesses, who was diagnosed with splenic tuberculosis and managed successfully with percutaneous drainage and anti-tubercular therapy alone. Read More

J Int Med Res 2018 Aug 18;46(8):3474-3479. Epub 2018 Jul 18.

1 Department of General Surgery, Beilun District People's Hospital, Ningbo, Zhejiang, China.

The incidence of tuberculosis is increasing worldwide, especially in developing countries. The prevalence of abdominal tuberculosis has been found to be as high as 12% in people with extrapulmonary tuberculosis. Peritoneal thickening and intestinal adhesions can occur in patients with abdominal tuberculosis. Read More

Med Mal Infect 2018 Dec 13;48(8):533-539. Epub 2018 Jul 13.

Maladies infectieuses et tropicales, hôpital Bichat, AP-HP, 46, rue Henri-Huchard, 75018 Paris, France; Inserm, IAME, UMR 1137, 16, rue Henri-Huchard, 75018 Paris, France; Université Paris-Diderot, IAME, UMR 1137, Sorbonne Paris Cité, 75018 Paris, France.

Background: Miliary tuberculosis (miliary TB) is characterized by a hematogenous spread of Mycobacterium tuberculosis. Cerebral lesions associated with miliary TB have been reported with diverse frequencies.

Methods: We retrospectively analyzed brain imaging in 34 patients presenting with proven miliary TB hospitalized in our teaching hospital between 2008 and 2014. Read More

J Thorac Dis 2018 May;10(5):2881-2889

Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Background: After the introduction of chemotherapy, miliary tuberculosis (TB) has been more prevalent in adults than in children. However, adult patients have a wide age range and may have different characteristics across the age span. Thus, clinical manifestations and treatment outcome may differ according to age groups in adult patients with miliary TB. Read More

Int J Tuberc Lung Dis 2018 Aug;22(8):844-850

Service de Pneumologie et d'Allergologie Pédiatriques, Hôpital Universitaire Necker-Enfants Malades, Paris, France.

Objective: To evaluate inter-reader agreement and diagnostic accuracy of chest radiography (CXR) in the diagnosis of tuberculosis (TB) in children with human immunodeficiency virus (HIV) infection.

Design: HIV-infected children with clinically suspected TB were enrolled in a prospective study conducted in Burkina Faso, Cambodia, Cameroon and Viet Nam from April 2010 to December 2014. Three readers-a local radiologist, a paediatric pulmonologist and a paediatric radiologist-independently reviewed the CXRs. Read More

Saudi J Kidney Dis Transpl 2018 May-Jun;29(3):719-722

Department of Internal Medicine, Keimyung University School of Medicine, Keimyung University Kidney Institution, Daegu, Korea.

A paradoxical reaction during anti-tuberculosis (anti-TB) therapy is commonly reported in patients with human immunodeficiency virus (HIV). However, a similar reaction to anti-TB therapy can also occur in patients without HIV, especially in patients who have undergone solid organ transplantation. A 65-year-old woman who underwent kidney transplantation six months prior presented to our emergency room with progressive paraparesis. Read More

Rev Esp Quimioter 2018 Aug 2;31(4):329-335. Epub 2018 Jul 2.

Andrés González García. Department of Internal Medicine. University Hospital Ramón y Cajal. Carretera Colmenar Km 9,4 28034 Madrid. Spain.

Objective: Although the incidence of human immunodeficiency virus (HIV)-associated tuberculosis (TB) has decreased, changes in other characteristics of the disease are largely unknown. To describe the trends in TB in patients infected with HIV from 1995 to 2013.

Methods: We review all cases of TB in a tertiary hospital in Madrid, Spain. Read More

Int J Tuberc Lung Dis 2018 Jul;22(7):779-787

Radiology Unit.

Background: Hepatic tuberculosis (TB) shows non-specific symptoms, and liver imaging may provide diagnostic clues. Here we describe a series of patients with hepatic TB showing characteristic radiological findings.

Methods: Single-centre retrospective evaluation of patients with hepatic TB diagnosed over a period of 16 years who underwent ultrasound, computed tomography (CT) and/or magnetic resonance imaging (MRI). Read More

Z Gastroenterol 2018 06 11;56(6):569-572. Epub 2018 Jun 11.

Jena University Hospital, Dept. Internal Medicine IV.

Nocardiosis is a rare infection caused by ubiquitous soil-born, acid-resistant, Gram-positive bacteria that can be life-threatening in immunocompromised patients. Originally usually diagnosed in HIV-positive patients, only few cases have been reported in patients on immunosuppressive therapy for inflammatory bowel disease or rheumatologic disorders. We present a case of a 32-year-old man who was treated with infliximab, prednisolone, and azathioprine for severe terminal ileitis. Read More

Med Mal Infect 2018 Oct 7;48(7):457-464. Epub 2018 Jun 7.

Inserm, CIC 1413, service de maladies infectieuses et tropicales, centre hospitalo-universitaire de Nantes, 1, place Alexis-Ricordeau, 44000 Nantes, France.

Objectives: To characterize multidrug-resistant tuberculosis (MDR-TB) patients treated in a low endemic area in France and to determine risk factors for resistance. We also analyzed the efficacy and tolerability of tuberculosis (TB) treatment.

Methods: Between 2002-2013, all MDR-TB patients diagnosed in western France (hospitals belonging to the GERICCO group) were retrospectively included, with a follow-up period running until 2016. Read More

BMC Med 2018 06 7;16(1):85. Epub 2018 Jun 7.

National Infections Service, Public Health England, 61 Colindale Avenue, London, NW9 5EQ, UK.

Background: HIV increases the progression of latent tuberculosis (TB) infection to active disease and contributed to increased TB in the UK until 2004. We describe temporal trends in HIV infection amongst patients with TB and identify factors associated with HIV infection.

Methods: We used national surveillance data of all TB cases reported in England, Wales and Northern Ireland from 2000 to 2014 and determined HIV status through record linkage to national HIV surveillance. Read More