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    Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages.
    Histochem Cell Biol 2017 Jan 27. Epub 2017 Jan 27.
    Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
    A major function of the skin is the regulation of body temperature by sweat secretions. Sweat glands secrete water and salt, especially NaCl. Excreted water evaporates, cooling the skin surface, and Na(+) ions are reabsorbed by the epithelial sodium channels (ENaC). Read More

    Foxc1 Ablated Mice Are Anhidrotic and Recapitulate Features of Human Miliaria Sweat Retention Disorder.
    J Invest Dermatol 2017 Jan 1;137(1):38-45. Epub 2016 Sep 1.
    Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
    Sweat glands are critical for thermoregulation. The single tubular structure of sweat glands has a lower secretory portion and an upper reabsorptive duct leading to the secretory pore in the skin. Genes that determine sweat gland structure and function are largely unidentified. Read More

    Inflammatory and glandular skin disease in pregnancy.
    Clin Dermatol 2016 May-Jun;34(3):335-43. Epub 2016 Feb 11.
    Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island; Department of Dermatology, Rhode Island Hospital, Providence, Rhode Island.
    A switch from cell-mediated to humoral immunity (helper T 1 [Th1] to helper T 2 [Th2] shift) during gestation plays a key role in placental immune tolerance. As a result, skin diseases that are Th2 mediated often worsen, whereas skin diseases that are Th1 mediated often improve during gestation. Also, due to fluctuations in glandular activity, skin diseases involving sebaceous and eccrine glands may flare, whereas those involving apocrine glands may improve during pregnancy. Read More

    Benign skin disease with pustules in the newborn.
    An Bras Dermatol 2016 Apr;91(2):124-34
    Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
    The neonatal period comprises the first four weeks of life. It is a period of adaptation where the skin often presents several changes: transient lesions, resulting from a physiological response, others as a consequence of transient diseases and some as markers of severe disorders. The presence of pustules in the skin of the newborn is always a reason for the family and for the assisting doctor to be worried, since the newborn is especially vulnerable to bacterial, viral or fungal infection. Read More

    Fox-Fordyce disease of the vulva.
    Indian J Sex Transm Dis 2016 Jan-Jun;37(1):65-7
    Department of Dermatology, Venereology and Leprosy, Saveetha Medical College and Hospital, Kancheepuram, Tamil Nadu, India.
    Fox-Fordyce disease is a rare, chronic skin disorder which affects the apocrine areas. This disease is due to the obstruction of the apocrine sweat duct. Extragenital regions are commonly affected than the genital region. Read More

    The effects of the El Niño Southern Oscillation on skin and skin-related diseases: a message from the International Society of Dermatology Climate Change Task Force.
    Int J Dermatol 2015 Dec 15;54(12):1343-51. Epub 2015 Oct 15.
    Division of Clinical Dermatology, Mayo Clinic, Rochester, MN, USA.
    The El Niño Southern Oscillation (ENSO) is a complex climate phenomenon occurring in the Pacific Ocean at intervals of 2-7 years. The term refers to fluctuations in ocean temperatures in the tropical eastern Pacific Ocean (El Niño [the warm phase of ENSO] and La Niña [the cool phase of ENSO]) and in atmospheric pressure across the Pacific basin (Southern Oscillation). This weather pattern is attributed with causing climate change in certain parts of the world and is associated with disease outbreaks. Read More

    Eruptive milia and comedones during treatment with dovitinib.
    Dermatol Online J 2015 Sep 17;21(9). Epub 2015 Sep 17.
    San Antonio Military Medical Center, Fort Sam Houston.
    Dovitinib (TKI258) is a multi-targeted receptor tyrosine kinase inhibitor currently under clinical trials for a wide variety of cancers. Well-known side effects include nausea, vomiting, diarrhea, and fatigue. To date, there have only been only two reported cases with skin manifestations as a side effect. Read More

    Hypohidrosis in Individuals with Exertional Heat Injury: A Prospective Open Cohort Study.
    Dermatology 2016 25;232(1):50-6. Epub 2015 Sep 25.
    National Skin Centre, Singapore, Singapore.
    Background: Hypohidrosis is a risk factor for developing heat-related illnesses.

    Objective: To determine the prevalence of hypohidrosis in heat injury.

    Methods: Soldiers from the Singapore Armed Forces who developed heat injury between January 1, 2012 and December 31, 2013 were invited to participate in the study. Read More

    Milia En Plaque as a Distinct Follicular Hamartoma With Cystic Trichoepitheliomatous Features.
    Am J Dermatopathol 2016 Mar;38(3):212-7
    Department of Dermatology, Tohoku University Graduate School of Medicine, Miyagi, Japan.
    Milia en plaque (MEP) is an uncommon disorder characterized by an erythematous plaque containing numerous milia. The pathogenesis of MEP is not clear. The authors report a man with an erythematous plaque on the right retroauricular area, containing numerous white-yellow cysts varying in size. Read More

    The evaluation and management of heat injuries in an intensive care unit.
    Indian J Crit Care Med 2015 Aug;19(8):479-83
    Department of General Medicine, Intensive Care Unit, RKDF Medical College Hospital and Research Centre, Bhopal, Madhya Pradesh, India.
    In this summer season (May-June 2014) most of the days temperature was more than 40°C. Our hospital is surrounded by huge slums area. The population which is low in socioeconomic status used to work in such high temperature for more than 8 h daily. Read More

    Dermal and Ophthalmic Findings in Pseudohypoaldosteronism.
    J Clin Res Pediatr Endocrinol 2015 Jun;7(2):155-8
    Erciyes University Faculty of Medicine, Department of Neonatology, Kayseri, Turkey Phone:+90 352 207 66 66 E-mail:
    Pseudohypoaldosteronism (PHA) is defined as a state of resistance to aldosterone, a hormone crucial for electrolyte equilibrium. The genetically transmitted type of PHA is primary hypoaldosteronism. Secondary hypoaldosteronism develops as a result of hydronephrosis or hydroureter. Read More

    The Infectious and Noninfectious Dermatological Consequences of Flooding: A Field Manual for the Responding Provider.
    Am J Clin Dermatol 2015 Oct;16(5):399-424
    Dermatology Division, Children's National Medical Center, Washington, DC, USA.
    Meteorological data show that disastrous floods are increasingly frequent and more severe in recent years, perhaps due to climatic changes such as global warming. During and after a flood disaster, traumatic injuries, communicable diseases, chemical exposures, malnutrition, decreased access to care, and even mental health disorders dramatically increase, and many of these have dermatological manifestations. Numerous case reports document typical and atypical cutaneous infections, percutaneous trauma, immersion injuries, noninfectious contact exposures, exposure to wildlife, and exacerbation of underlying skin diseases after such disasters as the 2004 Asian tsunami, Hurricane Katrina in 2005, and the 2010 Pakistan floods. Read More

    [UROLOGICAL ASPECTS OF THE FOX - FORDYCE DISEASE].
    Urologiia 2015 Jan-Feb(1):108-10
    The article presents the description of the clinical observation of the patient 28 years old with multiple granulomatous eruptions on the skin of the scrotum, accompanied by itching and pain when walking. Surgical treatment consisted of excising the skin of the scrotum and substitution dermatoplasty was performed. Fox - Fordyce disease was confirmed by histological examination of tissue removed: advanced cystic sebaceous gland duct with calcifications in its lumen was revealed. Read More

    Neonatal pustular dermatosis: an overview.
    Indian J Dermatol 2015 Mar-Apr;60(2):211
    Department of Skin and VD, PGIMS, Rohtak, Haryana, India.
    Neonatal pustular eruption is a group of disorders characterized by various forms of pustulosis seen in first 4 weeks of life. Its presentation is often similar with some subtle differences, which can be further established by few simple laboratory aids, to arrive at a definite diagnosis. Given their ubiquitous presentation, it is sometimes difficult to differentiate among self-limiting, noninfectious, pustular dermatosis such as erythema toxicum neonatorum, transient neonatal pustular melanosis, miliaria pustulosa, etc. Read More

    Multiple Cutaneous Creamy Papules and Nodules: A Case of Miliarial Gout.
    J Cutan Med Surg 2015 May-Jun;19(3):317-9. Epub 2015 Mar 13.
    Department of Dermatology and Skin Science and Division of Rheumatology, Department of Medicine, University of British Columbia, and Division of Dermatology, Department of Medicine, St. Paul's Hospital, Providence Health Care, Vancouver, BC.
    Background: Tophaceous gout is the nonarticular deposition of monosodium urate resulting from a disorder in purine metabolism that causes an elevation of serum uric acid. Cutaneous variants of tophaceous gout include papular, nodular, ulcerative, and pustular forms.

    Objective: We present a case of a 67-year-old man who presented with multiple cutaneous creamy white papules and nodules. Read More

    Histopathological and immunohistochemical features of nodular podoconiosis.
    J Cutan Pathol 2015 Mar 5;42(3):173-81. Epub 2015 Feb 5.
    Federal Ministry of Health Ethiopia, Addis Abeba, Ethiopia.
    Background: Podoconiosis is a familial geochemical dermatosis which is common in Ethiopia but relatively unknown in Europe/United States. It is related to exposure of bare feet to volcanic soil and presents with extensive bilateral lymphedema of legs and feet. Histopathological and immunohistochemical features of it have not been described yet. Read More

    Linear milia en plaque on the forearm.
    Skinmed 2014 Jul-Aug;12(4):250-1
    A 64-year-old man presented with asymptomatic eruption on his right forearm and the dorsum of the hand present for 2 weeks. There was no history of trauma, prolonged sun exposure, or application of or contact with any substance prior to the development of lesions. He was a known hypertensive and diabetic and was taking treatment for these conditions. Read More

    Rare benign tumours of the nipple.
    J Eur Acad Dermatol Venereol 2015 Jan 14;29(1):7-13. Epub 2014 Aug 14.
    Department of Plastic and Reconstructive Surgery, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.
    Background: Benign lesions of the breast in total are much more frequent than malignant ones. However, there are no epidemiologic data on the prevalence of benign or malignant tumours of the nipple, and the bibliography on benign nipple tumours in general is limited.

    Aims: To present some rare cases of benign nipple tumours and review the literature. Read More

    Dermatologic conditions in teenage adolescents in Nigeria.
    Adolesc Health Med Ther 2014 27;5:79-87. Epub 2014 May 27.
    Department of Pediatrics, University of Calabar, Calabar, Cross River State, Nigeria.
    Background: Skin disorders are common in adolescents, and the impact on quality of life can be enormous, particularly when viewed against the backdrop of the visibility of skin diseases and the psychologically vulnerable period of adolescence. However, few studies have documented the magnitude of skin disorders in this subset of individuals. We therefore estimated the point prevalence and pattern of dermatologic conditions in adolescents attending various secondary schools in Calabar, Southern Nigeria. Read More

    Milia en plaque of the nose: report of a case and successful treatment with topical tretinoin.
    Pediatrics 2014 May 7;133(5):e1373-6. Epub 2014 Apr 7.
    Department of Dermatology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts; Skin Care Physicians, Chestnut Hill, Massachusetts.
    Milia are benign, superficial keratinaceous cysts that present as fine, small white papules. Milia en plaque is a rare, challenging-to-treat variant most often seen in the posterior auricular region. A total of 9 cases of milia en plaque have been reported in the pediatric literature to date. Read More

    Ocular and skin manifestations in systemic pseudohypoaldosteronism.
    BMJ Case Rep 2014 Mar 20;2014. Epub 2014 Mar 20.
    Department of Paediatrics, AHMADI Hospital, Ahmadi, Kuwait.
    Pseudohypoaldosteronism type-1 is a rare disorder characterised by end-organ resistance to aldosterone resulting in salt-losing crisis with hyponatraemic dehydration, hyperkalaemia and metabolic acidosis. We report two siblings with pseudohypoaldosteronism type-1 who presented early in neonatal period with hyponatraemia, severe hyperkalaemia and metabolic acidosis. Both babies had miliaria like skin rash which flared up during episodes of hyperkalaemia and hyponatraemia. Read More

    A cross-sectional prospective study of cutaneous lesions in newborn.
    ISRN Dermatol 2014 20;2014:360590. Epub 2014 Jan 20.
    Department of Dermatology, Shri B. M. Patil Medical College, BLDE University, Bijapur, Karnataka 586103, India.
    Background. Cutaneous alterations are common in neonates. The majority of lesions are physiological, transient, or self-limited and require no therapy. Read More

    Fox Fordyce disease as a secondary effect of laser hair removal.
    J Cosmet Laser Ther 2014 Jun 18;16(3):141-3. Epub 2013 Nov 18.
    Department of Dermatology, Clinic University of Navarra , Pamplona , Spain.
    Fox Fordyce disease (FFD) has been recently described as an adverse effect of laser hair removal. It is an apocrine gland disorder characterized by pruritus and a folliculocentric papular eruption in apocrine sweat gland areas. Different etiologies have been proposed to be the cause of this entity. Read More

    Multiple eruptive milia.
    Cutis 2013 Apr;91(4):191-2
    Philadelphia VA Medical Center, Pennsylvania, USA.
    Multiple eruptive milia (MEM) is a rare skin condition characterized by sudden onset of multiple milia occurring mainly on the head, neck, and trunk. Milia are small, benign, 1- to 4-mm, white keratinous cysts. The lesions generally are asymptomatic and may arise spontaneously or secondary to a number of processes. Read More

    The oldest new finding in atopic dermatitis: subclinical miliaria as an origin.
    JAMA Dermatol 2013 Apr;149(4):436-8
    Department of Dermatology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19107, USA.
    Importance: In 1947, Sulzberger and colleagues published a micrograph of a blocked acrosyringium in a patient with atopic dermatitis (AD), believing that it had a large role in the disease process. Lacking appropriate probes, they could not confirm the finding.

    Objective: To confirm the observations by Sulzberger et al on the blockage of sweat ducts in AD in pathologic specimens. Read More

    Spectrum of pediatric dermatoses in tertiary care center in Nepal.
    Nepal Med Coll J 2012 Jun;14(2):146-8
    Department of Dermatology, KIST Medical College, Lalitpur, Nepal.
    Children with dermatological problems constitute a major group presenting to the Outpatient Department. This study was done to see the pattern of skin disorder among the pediatric age group in a tertiary care center in Nepal. To determine the pattern of skin disorders among children visiting the Department of Dermatology and Pediatrics in a tertiary care center in Nepal. Read More

    Skin conditions: common skin rashes in infants.
    FP Essent 2013 Apr;407:31-41
    San Joaquin General Hospital, French Camp, CA 95231, USA.
    Infants exhibit many skin rashes. Erythema toxicum neonatorum presents as erythematous macules, papules, and pustules on the face, trunk, and extremities; it typically resolves spontaneously within 1 week. Neonatal acne presents as comedones or erythematous papules on the face, scalp, chest, and back. Read More

    Fox-Fordyce-like disease following laser hair removal appearing on all treated areas.
    Lasers Med Sci 2013 Jul 15;28(4):1205-7. Epub 2013 Jan 15.
    Dermatology Department, Hôtel-Dieu de France Hospital, Beirut, Lebanon.
    Fox-Fordyce disease is an uncommon inflammatory disease of the apocrine sweat glands. Two recent reports indicated laser hair removal as a novel cause of axillary Fox-Fordyce disease. We report the first case of Fox-Fordyce disease developing in women after completing treatment with a depilatory hair laser appearing in the axillae, umbilicus, and pubis. Read More

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