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    Metaboreflex-mediated hemodynamic abnormalities in individuals with coronary artery disease without overt signs or symptoms of heart failure.
    Am J Physiol Heart Circ Physiol 2017 Nov 10:ajpheart.00436.2017. Epub 2017 Nov 10.
    University of Cagliari
    This study was devised to investigate the effect of coronary artery disease (CAD) without overt signs of heart failure on the cardiovascular responses to muscle metaboreflex activation. We hypothesized that any CAD-induced pre-clinical systolic and/or diastolic dysfunction could impair hemodynamic response to the metaboreflex test. Twelve males diagnosed with CAD without any sign or symptoms of heart failure and 11 age-matched healthy controls (CTL) participated in the study. Read More


    Workplace health promotion programs for older workers in Italy.
    Med Lav 2017 Oct 27;108(5):6229. Epub 2017 Oct 27.
    Università Cattolica del Sacro Cuore, Roma.
    Background: Italy is the European country with the highest number of citizens over the age of sixty. In recent years, the unsustainability of the social security system has forced the Italian government to raise the retirement age and reduce the chances of early exit, thus sharply increasing the age of the workforce. Consequently, a significant proportion of older workers are currently obliged to do jobs that were designed for young people. Read More

    Environmental Pollution by Benzene and PM10 and Clinical Manifestations of Systemic Sclerosis: A Correlation Study.
    Int J Environ Res Public Health 2017 Oct 26;14(11). Epub 2017 Oct 26.
    Institute of Public Health-Hygiene Section, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.
    Atmospheric air pollution has been associated with a range of adverse health effects. The environment plays a causative role in the development of Systemic Sclerosis (SSc). The aim of the present study is to explore the association between particulate (PM10) and benzene (B) exposure in Italian patients with systemic sclerosis and their clinical characteristics of the disease. Read More

    Dental pulp regeneration via cell homing.
    Int Endod J 2017 Oct 19. Epub 2017 Oct 19.
    Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
    The typical treatment for irreversibly inflamed/necrotic pulp tissue is root canal treatment. As an alternative approach, regenerative endodontics aims to regenerate dental pulp-like tissues using two possible strategies: cell transplantation and cell homing. The former requires exogenously transplanted stem cells, complex procedures and high costs; the latter employs the host's endogenous cells to achieve tissue repair/regeneration, which is more clinically translatable. Read More

    Eruptive milia during isotretinoin therapy.
    Pediatr Dermatol 2017 Nov 21;34(6):728-729. Epub 2017 Sep 21.
    Department of Dermatology, Children's National Health System, Washington, DC, USA.
    Isotretinoin (13-cis-retinoic acid) is a synthetic vitamin A derivative that is effective in the treatment of recalcitrant, nodulocystic acne. To our knowledge, there are no reports in the medical literature of milia as a side effect of isotretinoin. We report a case of eruptive facial milia in the setting of isotretinoin treatment for acne. Read More

    Thoracic Irrigation Prevents Retained Hemothorax: A Prospective Propensity Scored Analysis.
    J Trauma Acute Care Surg 2017 Sep 20. Epub 2017 Sep 20.
    Medical College of Wisconsin, Department of Surgery, Division of Trauma and Critical Care, 9200 W. Wisconsin Ave. Milwaukee, WI 53226 United States Medical College of Wisconsin, Department of Surgery, Division of Trauma and Critical Care, 9200 W. Wisconsin Ave. Milwaukee, WI 53226 United States Medical College of Wisconsin, Department of Surgery, Division of Trauma and Critical Care, 9200 W. Wisconsin Ave. Milwaukee, WI 53226 United States University of New Mexico, Department of Surgery, Division of General Surgery, MSC10 5610 1 University of New Mexico, Albuquerque, NM 87131 United States.
    Background: Thoracic trauma resulting in hemothorax (HTx) is typically managed with thoracostomy tube (TT) placement; however, up to 20% of patients develop retained HTx which may necessitate further intervention for definitive management. While optimal management of retained HTx has been extensively researched, little is known about prevention of this complication. We hypothesized thoracic irrigation at the time of TT placement would significantly decrease the rate of retained HTx necessitating secondary intervention. Read More

    A prospective randomized controlled trial to identify the optimal postoperative pain management in shoulder arthroplasty: liposomal bupivacaine versus continuous interscalene catheter.
    J Shoulder Elbow Surg 2017 Oct 24;26(10):1810-1817. Epub 2017 Aug 24.
    Department of Orthopaedic Surgery, Beaumont Health, Taylor, MI, USA.
    Background: Shoulder arthroplasty is the fastest growing joint replacement surgery in the United States, and optimal postoperative pain management is critical to optimize outcomes for these surgeries. Liposomal bupivacaine (LB) has gained popularity for its potential to provide extended postoperative pain relief with possibly fewer side effects. The goal of this study was to assess the impact of LB compared with continuous interscalene nerve block (CISB) in terms of postoperative pain control, outpatient pain scores, and patient-reported and functional outcomes after shoulder arthroplasty surgery. Read More

    [Risk perception and biological parameters related to obesity in a sample population of the city of Rome, Italy: nurses' contribution to supporting health-related decisions].
    Ig Sanita Pubbl 2017 May-Jun;73(3):215-234
    Istituto di Sanità Pubblica, Sezione di Igiene, Università Cattolica del Sacro Cuore, Roma, Italia.
    Introduction: Obesity is a major public health problem because it is a risk factor for various chronic diseases and its incidence is constantly increasing due to changes in diet and lifestyle. In Italy, studies show that 32% of the population aged between 18 and 69 years is overweight and 10% is obese. The aim of this study was to measure the anthropometric characteristics of a sample population of the city of Rome (Italy) and correlate these with dietary habits and socio-demographic characteristics of participants in order to evaluate their specific health and educational needs. Read More

    A "Sacra Rappresentazione" of Saint Apollonia's Martyrdom.
    J Hist Dent 2017 Summer/Fall;65(2):63-72
    Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
    The literary sources of Saint Apollonia's martyrdom and the evolution of Medieval and Renaissance religious drama are presented along with the compendium of a "Sacra Rappresentazione" from Italian Renaissance regarding Saint Apollonia's Martyrdom. Read More

    Immune-checkpoint inhibitors associated with interstitial lung disease in cancer patients.
    Eur Respir J 2017 08 10;50(2). Epub 2017 Aug 10.
    Service de Pneumologie, Hôpital Larrey, Centre Hospitalier Universitaire, Université Paul Sabatier, Toulouse, France
    Immunotherapy is becoming a standard of care for many cancers. Immune-checkpoint inhibitors (ICI) can generate immune-related adverse events. Interstitial lung disease (ILD) has been identified as a rare but potentially severe event. Read More

    Park availability and major depression in individuals with chronic conditions: Is there an association in urban India?
    Health Place 2017 Sep 25;47:54-62. Epub 2017 Jul 25.
    Centre for Control of Chronic Conditions, Gurgaon, India; Centre for Chronic Disease Control, Gurgaon, India; Public Health Foundation of India, Gurgaon, India; London School of Hygiene&Tropical Medicine, UK. Electronic address:
    Green space exposure has been positively correlated with better mental-health indicators in several high income countries, but has not been examined in low- and middle-income countries undergoing rapid urbanization. Building on a study of mental health in adults with a pre-existing chronic condition, we examined the association between park availability and major depression among 1208 adults surveyed in Delhi, India. Major depression was measured using the Mini International Neuropsychiatric Interview. Read More

    Association between full service and fast food restaurant density, dietary intake and overweight/obesity among adults in Delhi, India.
    BMC Public Health 2017 Jul 19;18(1):36. Epub 2017 Jul 19.
    Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
    Background: The food environment has been implicated as an underlying contributor to the global obesity epidemic. However, few studies have evaluated the relationship between the food environment, dietary intake, and overweight/obesity in low- and middle-income countries (LMICs). The aim of this study was to assess the association of full service and fast food restaurant density with dietary intake and overweight/obesity in Delhi, India. Read More

    Peritoneal Equilibration Test Reference Values Using a 3.86% Glucose Solution During the First Year of Peritoneal Dialysis: Results of a Multicenter Study of a Large Patient Population.
    Perit Dial Int 2017 Nov-Dec;37(6):633-638. Epub 2017 Jul 11.
    Nephrology and Dialysis Department, Civile Hospital, Vimercate, Italy.
    Background: The original peritoneal equilibration test (PET) was used to classify peritoneal dialysis (PD) patients using a 2.27% glucose solution. It has since been suggested that a 3. Read More

    [Charges and convictions of psychiatrists for the violent behavior of the patient: psychiatric-forensic remarks].
    Riv Psichiatr 2017 May-Jun;52(3):101-108
    Clinica Psichiatrica, Università di Sassari.
    Purpose of the present study is to point-out a number of psychiatric-forensic remarks about the management of violent behavior against the person (VBP) amongst psychiatric patients. The study is the authors' personal contribution based on clinical and forensic experience as experts in the management of psychiatric patients with VBP. Twelve psychiatric-forensic remarks have been highlighted in the present study: 1) VBP is a multifactorial event; 2) the risk of VBP against the person may change rapidly over time in quantity and quality; 3) there are no methods for reliable prediction of VBP in a single clinical-case; 4) there are no medications with an indication of "heal" the VBP; 5) there are no therapeutic measures that neutralize always, quickly and without recurrences VBP; 6) there exist clinical hypotheses to assess VBP; 7) there exist principles of victimology to assess VBP; 8) there are emotional reactions that can affect the evaluation and clinical and forensic management of VBP; 9) the responsibility of the psychiatrist has to be evaluated at the moment of the events; 10) the responsibility of the psychiatrist must be contextualized in the single clinical-case; 11) there is the need to clarify the individual professional responsibility of psychiatrists who treated a patient; 12) there is the need to clarify the criteria for the definition of the guarantee role. Read More

    Eruptive Milia Within a Tattoo: A Case Report and Review of the Literature.
    J Drugs Dermatol 2017 Jun;16(6):621-624

    Of the many tattoo reactions the most common are allergic, granulomatous, lichenoid, photosensitive, pseudolymphomatous, and infectious. Eruptive milia are a rare complication with only three prior reports in the English literature. A 19-year-old African American female presented with tiny, white papules confined within the margins of a tattoo. Read More


    Detectable cerebrospinal fluid JCV DNA in late-presenting HIV-positive patients: beyond progressive multifocal leukoencephalopathy?
    J Neurovirol 2017 Oct 5;23(5):763-767. Epub 2017 Jul 5.
    Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Amedeo di Savoia Hospital, C.so Svizzera 164, 10149, Turin, Italy.
    In the absence of effective prophylaxis and treatment, therapeutic options in HIV-positive patients with progressive multifocal leukoencephalopathy (PML) are limited to antiretroviral therapy: nevertheless, outcome is poor. We conducted a retrospective study (2009-2015) describing the outcome of 25 HIV-positive patients with detectable cerebrospinal fluid JC virus DNA: 14 had a probable PML while the others had evidence of other inflammatory central nervous system (CNS) affecting disorders. In the former group, 6-month mortality was 45. Read More

    Advances in new psychoactive substances identification: the U.R.I.To.N. Consortium.
    J Enzyme Inhib Med Chem 2017 Dec;32(1):841-849
    b Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Polo Scientifico , Università degli Studi di Firenze , Sesto Fiorentino, Florence , Italy.
    Identification of new psychoactive substances (NPS) in biological and non-biological samples represents a hard challenge for forensic toxicologists. Their great chemical variety and the speed with which new NPS are synthesised and spread make stringent the need of advanced tools for their detection based on multidisciplinary approaches. For this reason, in August 2016, the "Unit of Research and Innovation in Forensic Toxicology and Neuroscience of Addiction" (U. Read More

    Total hip prosthesis complication, periprosthetic infection with external fistulizing due to Enterobacter cloacae complex multiple drugs resistance: A clinical case report.
    Int J Surg Case Rep 2017 17;36:90-93. Epub 2017 May 17.
    Department of Orthopaedic, University of Sassari, Sardinia, Italy.
    Introduction: The Enterobacter cloacae is a microorganism found in the intestinal flora of the majority of animals, including humans. Primary infections caused by E. cloacae are rare in immunocompetent patients, but are very common in hospital settings in newborns and immunocompromised patients, and can be aggravated by the insurgence of antibiotic resistance. Read More

    APLASIA CUTIS CONGENITA TYPE I - A CASE SERIES.
    Georgian Med News 2017 Mar(264):7-11
    Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany; Onkoderma - Policlinic of Dermatology and Dermatologic Surgery, Sofia, Bulgaria; Nirvana Skin Clinic, Vadodara, Gujarat, India; Medical Institute of MVR, Department of Dermatology and Venereology, Sofia, Bulgaria; Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.
    Aplasia Cutis Congenita is a rare disorder with circumscribed, partial or widespread absence of skin and subcutaneous soft tissue; in about 20% it also causes skull defects. The disease is heterogeneous in its clinical presentation with nine major subtypes. Type I represents nonsyndromic Aplasia Cutis Congenita. Read More

    Targeting RET in Patients With RET-Rearranged Lung Cancers: Results From the Global, Multicenter RET Registry.
    J Clin Oncol 2017 May 13;35(13):1403-1410. Epub 2017 Mar 13.
    Oliver Gautschi, Kristin Zeidler, and Joachim Diebold, Lucerne Cantonal Hospital, Luzern; Patrizia Froesch, Ente Ospedaliero Cantonale, Bellinzona; Martin Früh, Kantonsspital St Gallen, St Gallen; Sacha I. Rothschild, University Hospital Basel, Basel, Switzerland; Julie Milia and Julien Mazières, Hôpital Larrey; Thomas Filleron, Institut Universitaire du Cancer, Claudius Regaud, Toulouse; Benjamin Besse and Jordi Remon-Masip, Institute Gustave Roussy, Villejuif; Gérard Zalcman, University Hospital Bichat, Paris; Isabelle Monnet, Centre Hospitalier Intercommunal de Creteil, Creteil; Florian Cabillic, Université de Rennes 1, Rennes, France; Juergen Wolf and Sebastian Michels, Center for Integrated Oncology, Cologne; Georg Pall, Fachkliniken Wangen, Wangen Im Allgäu; Arne Warth, Heidelberg University Hospital; Thomas Muley, Thoraxklinik at University of Heidelberg and Translational Lung Research Center, Heidelberg, Germany; David P. Carbone and Dwight Owen, Ohio State University Comprehensive Cancer Center, Columbus; Vamsidhar Velcheti, Cleveland Clinic, Pepper Pike, OH; Ross Camidge and Vignhesh Narayanan, University of Colorado, Denver; Robert C. Doebele, University of Colorado, Aurora, CO; Pasi A. Janne and Mark M. Awad, Dana-Farber Cancer Institute, Boston, MA; Daniel D. Karp, The University of Texas MD Anderson Cancer Center, Houston, TX; Heather A. Wakelee and Joel W. Neal, Stanford University, Stanford; Sai-Hong Ignatius Ou, University of California, Irvine, Orange; David R. Gandara and Jonathan W. Riess, University of California, Davis Cancer Center, Sacramento, CA; Alexander Drilon, Memorial Sloan Kettering Cancer Center, New York, NY; Nir Peled, Davidoff Cancer Center, Petach Tiqwa, Israël; Chul-Cho Byoung, Yonseï Cancer Center, Seoul, Republic of Korea; Michael Van Den Heuvel, Netherlands Cancer Institute, Amsterdam, the Netherlands; Tony S.K. Mok, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China; James C.H. Yang and Jin-Yuan Shih, National Taiwan University Hospital, Taipei, Republic of China; Sanjay Popat, Royal Marsden Hospital, London, United Kingdom; and Rafael Rosell and Niki Karachaliou, Catalan Institute of Oncology, Barcelona, Spain.
    Purpose In addition to prospective trials for non-small-cell lung cancers (NSCLCs) that are driven by less common genomic alterations, registries provide complementary information on patient response to targeted therapies. Here, we present the results of an international registry of patients with RET-rearranged NSCLCs, providing the largest data set, to our knowledge, on outcomes of RET-directed therapy thus far. Methods A global, multicenter network of thoracic oncologists identified patients with pathologically confirmed NSCLC that harbored a RET rearrangement. Read More

    Dermoscopy-pathology relationship in seborrheic keratosis.
    J Dermatol 2017 May;44(5):518-524
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
    Making a definitive diagnosis of seborrheic keratosis (SK) can be challenging for the naked eye due to its wide variation in clinical features. Fortunately, however, most cases of SK exhibit the typical dermoscopic findings of fissures and ridges, hairpin vessels with white halo, comedo-like openings, and milia-like cysts, all of which are helpful to distinguish SK from melanoma, melanocytic nevus, squamous cell carcinoma, basal cell carcinoma (BCC) and other skin tumors. Histopathologically, these dermoscopic characteristics correspond to papillomatous surface of the epidermis, enlarged capillaries of the dermal papillae, pseudohorn cysts in the epidermis opened to the surface of the lesion and intraepidermal cysts, respectively. Read More

    Hospital efficiency: how to spend less maintaining quality?
    Ann Ist Super Sanita 2017 Jan-Mar;53(1):46-53
    President, Istituto Superiore di Sanità, Rome, Italy.
    Introduction: The recent global economic crisis is pushing governments worldwide to obtain a more explicit and urgent rationing of resources. The purpose of this study is to provide, through Data Envelopment Analysis (DEA), a methodological framework useful for investigating technical efficiency of hospital care.

    Methods: To validate such framework, we compared 50 Italian public hospital trusts (AOs) to identify relative efficient using inputs and outputs from national databases. Read More

    Dermoscopic Clues for Diagnosing Melanomas That Resemble Seborrheic Keratosis.
    JAMA Dermatol 2017 Jun;153(6):544-551
    Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
    Importance: Melanomas that clinically mimic seborrheic keratosis (SK) can delay diagnosis and adequate treatment. However, little is known about the value of dermoscopy in recognizing these difficult-to-diagnose melanomas.

    Objective: To describe the dermoscopic features of SK-like melanomas to understand their clinical morphology. Read More

    Onset of Coagulation Function Recovery Is Delayed in Severely Injured Trauma Patients with Venous Thromboembolism.
    J Am Coll Surg 2017 Jul 16;225(1):42-51. Epub 2017 Mar 16.
    Division of Trauma, Critical Care and Acute Care Surgery, Department of Surgery, Oregon Health & Science University, Portland, OR.
    Background: Altered coagulation function after trauma can contribute to development of venous thromboembolism (VTE). Severe trauma impairs coagulation function, but the trajectory for recovery is not known. We hypothesized that enhanced, early recovery of coagulation function increases VTE risk in severely injured trauma patients. Read More

    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Assessment of intradialysis calcium mass balance by a single pool variable-volume calcium kinetic model.
    Hemodial Int 2017 Feb 5. Epub 2017 Feb 5.
    Depatments of Nephrology and Dialysis, A. Manzoni Hospital, Lecco, Italy.
    Introduction: A reliable method of intradialysis calcium mass balance quantification is far from been established. We herein investigated the use of a single-pool variable-volume Calcium kinetic model to assess calcium mass balance in chronic and stable dialysis patients.

    Methods: Thirty-four patients on thrice-weekly HD were studied during 240 dialysis sessions. Read More

    Circadian preferences in young adults: Psychometric properties and factor structure of the Portuguese version of the Preferences Scale (PS-6).
    Chronobiol Int 2017 31;34(3):403-410. Epub 2017 Jan 31.
    e Faculty of Medicine, University of Coimbra , Coimbra , Portugal.
    Morningness is a trait-like variable which has been extensively studied within chronobiology. Despite the number of existing measures to assess morningness, there is a need for brief instruments that are psychometrically sound to be used in applied settings. Accordingly, the modified version of the Preferences Scale (PS-6) comprises six items and was reported to have adequate reliability and satisfactory validity indicators. Read More

    The connecting link! Lip prints and fingerprints.
    J Forensic Dent Sci 2016 Sep-Dec;8(3):177
    Department of Orthodontics, Jamia Milia Islamia University, Jamia Nagar, New Delhi, India.
    Background: Lip prints and fingerprints are considered to be unique to each individual. The study of fingerprints and lip prints is very popular in personal identification of the deceased and in criminal investigations.

    Aims: This study was done to find the predominant lip and fingerprint patterns in males and females in the North Indian population and also to find any correlation between lip print and fingerprint patterns within a gender. Read More

    Cilia Control Vascular Mural Cell Recruitment in Vertebrates.
    Cell Rep 2017 Jan;18(4):1033-1047
    Vesalius Research Center, VIB-KUL, Leuven 3000, Belgium; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, Turin 10126, Italy. Electronic address:
    Vascular mural cells (vMCs) are essential components of the vertebrate vascular system, controlling blood vessel maturation and homeostasis. Discrete molecular mechanisms have been associated with vMC development and differentiation. The function of hemodynamic forces in controlling vMC recruitment is unclear. Read More

    Milia may originate from the outermost layers of the hair bulge of the outer root sheath: A case report.
    Oncol Lett 2016 Dec 2;12(6):5190-5192. Epub 2016 Nov 2.
    Department of Pathology, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan.
    It has been hypothesized that milia originate from the hair bulge of the outer root sheath. To elucidate the histogenesis of milia, an immunohistochemical study was performed using anti-keratin and anti-filaggrin antibodies to determine the levels of keratin and filaggrin expression. Keratin expression was evaluated using anti-keratin antibodies against K1, K7, K8, K10, K14, K15, K16, K17, K18, K19 and K20. Read More

    3-MeO-PCP intoxication in two young men: First in vivo detection in Italy.
    Forensic Sci Int 2017 May 26;274:7-12. Epub 2016 Dec 26.
    Forensic Toxicology Division, Department of Health Science, University of Florence, Italy. Electronic address:
    3-MeO-PCP or 3-methoxyphencyclidine is a derivative of phencyclidine. It acts as a dissociative anesthetic and it has allegedly hallucinogenic and sedative effects. There are almost no documented intoxication cases and references about its pharmacology and toxicity in literature. Read More

    The peritoneal sieving of sodium: a simple and powerful test to rule out the onset of encapsulating peritoneal sclerosis in patients undergoing peritoneal dialysis.
    J Nephrol 2016 Dec 24. Epub 2016 Dec 24.
    Department of Nephrology and Dialysis, A. Manzoni Hospital, Via dell'Eremo 9/11, 23900, Lecco, Italy.
    Background And Aims: Encapsulating peritoneal sclerosis (EPS) is an uncommon but severe complication of peritoneal dialysis (PD). A reliable screening tool to identify patients at risk of developing or not EPS is currently not available. We aimed to evaluate whether the reduction in dialysate sodium concentration (sodium sieving) at 60 min (ΔDNa60), during a peritoneal equilibration test with 3. Read More

    Multiple Milia as an Isolated Skin Manifestation of Dominant Dystrophic Epidermolysis Bullosa: Evidence of Phenotypic Variability.
    Pediatr Dermatol 2017 03 23;34(2):e106-e108. Epub 2016 Dec 23.
    Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
    We report a Japanese pedigree with dominant dystrophic epidermolysis bullosa (DDEB) harboring the p.G2251E mutation of COL7A1. The proband of this pedigree presented with multiple milia as an isolated skin manifestation without a history of blistering and subsequently developed generalized intractable blisters, suggesting that multiple milia could be a primary manifestation of DDEB. Read More

    The RAS-related GTPase RHOB confers resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer via an AKT-dependent mechanism.
    EMBO Mol Med 2017 Feb;9(2):238-250
    Inserm, Centre de Recherche en Cancérologie de Toulouse, CRCT UMR-1037, Toulouse, France
    Although lung cancer patients harboring EGFR mutations benefit from treatment with EGFR-tyrosine kinase inhibitors (EGFR-TKI), most of them rapidly relapse. RHOB GTPase is a critical player in both lung carcinogenesis and the EGFR signaling pathway; therefore, we hypothesized that it could play a role in the response to EGFR-TKI In a series of samples from EGFR-mutated patients, we found that low RHOB expression correlated with a good response to EGFR-TKI treatment while a poor response correlated with high RHOB expression (15.3 versus 5. Read More

    High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: a nationwide longitudinal study, 2004-2013.
    Sci Rep 2016 Dec 19;6:38844. Epub 2016 Dec 19.
    Centre of Epidemiology and Biostatistics, Polytechnic University of Marche, Ancona, Italy.
    This longitudinal population-based study analyses the frequency of diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis in Italian children under 15 years of age, during 2004-2013. DKA was defined as absent (pH ≥ 7.30), mild/moderate (7. Read More

    Hemodynamic response to muscle reflex is abnormal in patients with heart failure with preserved ejection fraction.
    J Appl Physiol (1985) 2017 Feb 15;122(2):376-385. Epub 2016 Dec 15.
    Department of Medical Sciences, Sports Physiology Lab., University of Cagliari, Cagliari, Italy; and
    The aim of the present investigation was to assess the role of cardiac diastole on the hemodynamic response to metaboreflex activation. We wanted to determine whether patients with diastolic function impairment showed a different hemodynamic response compared with normal subjects during this reflex. Hemodynamics during activation of the metaboreflex obtained by postexercise muscle ischemia (PEMI) was assessed in 10 patients with diagnosed heart failure with preserved ejection fraction (HFpEF) and in 12 age-matched healthy controls (CTL). Read More

    Haemodiafiltration at Higher Volumes and Patient Survival.
    Contrib Nephrol 2017 12;189:1-8. Epub 2016 Dec 12.
    Patient morbidity and mortality rates are still very high in standard low-flux haemodialysis (lf-HD). On-line haemodiafiltration (OL-HDF) is considered the most efficient dialysis technique, as clearances of small solutes, like urea, may be even higher than in lf-HD and clearances of middle solutes, like β2-microglobulin, are much higher than in lf-HD. OL-HDF has been suggested to reduce mortality compared to HD, possibly due to more effective removal of larger uraemic retention solutes and/or better fluid removal. Read More

    Knowledge, attitudes and behaviors of the Italian population towards Neisseria meningitidis, Streptococcus pneumoniae and HPV diseases and vaccinations: A cross-sectional multicentre study.
    Public Health 2016 Dec 14;141:136-142. Epub 2016 Oct 14.
    Istituto di Sanità Pubblica - Sezione di Igiene, Università Cattolica del Sacro Cuore, Roma, Italy.
    Objectives: This study addressed knowledge of Streptococcus pneumoniae, Neisseria meningitidis and human papillomavirus (HPV), and attitudes and behaviours towards vaccines against them.

    Study Design: This is a cross-sectional, multicentre study.

    Methods: Data were collected through a questionnaire administered to 530 adults who accessed four Departments of Prevention of the Italian National Health Service in 2013. Read More

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