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    Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.
    Neuron 2018 Mar;97(6):1268-1283.e6
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:
    To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Read More

    Idiopathic multiple eruptive milia: Report of a case in a nigerian woman.
    Niger J Clin Pract 2018 Mar;21(3):395-396
    Dermatology Unit, Department of Medicine, Barau Dikko Teaching Hospital, Kaduna, Nigeria.
    Milia are multiple, small, benign keratin-filled superficial epidermoid cysts which are classified as primary when they occur spontaneously or secondary when they result from skin trauma or disease. Multiple eruptive milia (MEM) refer to a condition characterized by a sudden eruption of a large number of milia. MEM may be familial, occur as part of a genodermatosis, or occur spontaneously when they are termed idiopathic. Read More

    [Porphyria cutanea tarda as extrahepatic manifestation of chronic hepatitis C: a case report].
    Rev Gastroenterol Peru 2017 Oct-Dec;37(4):394-398
    Facultad de Medicina, Universidad Peruana Cayetano Heredia. Lima, Perú.
    The present case is a 56 year old male who present hyperpigmented and hypopigmented scars in both hands, associated with the presence of milia cysts. It was studied the metabolism of porphyrins and skin biopsy of the lesions which were compatible with porphyria cutanea tarda. In the initial laboratory, elevated transaminases values were found and subsequently identified chronic infection of hepatitis C virus. Read More

    Laboratory findings in Zika infection: The experience of a reference centre in North-West Italy.
    J Clin Virol 2018 Apr 31;101:18-22. Epub 2018 Jan 31.
    Laboratory of Microbiology and Virology, Amedeo di Savoia Hospital, Turin, Italy.
    Background: Zika virus (ZIKV) remains a public health concern due to its association with fetal malformation and neurologic disease.

    Objective: To report a reference centre experience on ZIKA virus (ZIKV) infection in travelers from epidemic countries from January 1 to September, 30, 2016 in Italy North-West (a geographic area covering 4.424 million inhabitants, corresponding to almost 73% of Italy North-West area). Read More

    [Trazodone prolonged release in bipolar disorder II-obsessive-compulsive disorder comorbidity: a case report].
    Riv Psichiatr 2017 Nov-Dec;52(6):255-257
    Clinica Psichiatrica Universitaria di Sassari-Dipartimento di Medicina Clinica e Sperimentale-AOU Sassari.
    Approximately 21% of patients with bipolar disorder (BD) also have an additional diagnosis of obsessive-compulsive disorder (OCD). This condition is associated with a more severe prognosis and complicates the treatment of BD. In our case report we provide documentary evidence of our experience with trazodone prolonged release in the treatment of depressive phase in a patient with BD II-OCD comorbidity. Read More

    Hemodynamic Responses during Enduro-Motorcycling Performance.
    Front Physiol 2017 14;8:1062. Epub 2017 Dec 14.
    Department of Medical Science and Public Health, Sports Physiology Laboratory, University of Cagliari, Cagliari, Italy.
    Much of the information available in the literature on physiological responses during Enduro motorcycling is related to heart rate (HR) and blood lactate (BLa). The aim of this work was to investigate the hemodynamic changes that occur during a 10-min session of Enduro motorcycling. Fifteen skilled riders were enrolled on the study and all participants underwent an Enduro-motorcycling session on a standard track. Read More

    Heterozygous Deletion Impacting SMARCAD1 in the Original Kindred with Absent Dermatoglyphs and Associated Features (Baird, 1964).
    J Pediatr 2018 Mar 18;194:248-252.e2. Epub 2017 Dec 18.
    Section of Dermatology, Department of Pediatrics, The Children's Hospital of Philadelphia and University of Pennsylvania Perlman School of Medicine, Philadelphia, PA. Electronic address:
    In 1964, Baird described a family with adermatoglyphia, facial milia, and skin fragility. Using whole exome sequencing, genotyping, and Sanger sequencing, we identified a 116-kb heterozygous deletion involving exons 1-9 of SMARCAD1 in descendants of this kindred. This contrasts with point mutations within exon 9 in all other reported families. Read More

    Pretibial dystrophic epidermolysis bullosa.
    An Bras Dermatol 2017 ;92(5 Suppl 1):126-128
    Department of Dermatopathology of the Department of Anatomic Pathology, Santa Casa de Misericórdia de São Paulo - São Paulo (SP), Brazil.
    Epidermolysis bullosa is a group of mechano-bullous genetic disorders caused by mutations in the genes encoding structural proteins of the skin. Dystrophic epidermolysis bullosa is caused by mutations in the COL7A1 gene encoding collagen VII, the main constituent of anchoring fibrils. In this group, there are autosomal dominant and recessive inheritances. Read More

    Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patient.
    An Bras Dermatol 2017 ;92(5 Suppl 1):34-36
    Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China.
    Bullous pemphigoid is a blistering autoimmune disease characterized by two hemidesmosomal proteins (anti-BP180 and 230). Pemphigus, by contrast, is characterized by two autoantibodies (anti-desmoglein 1 and 3). Coexistence of autoantibodies of bullous pemphigoid and pemphigus in a patient is rare. Read More

    Effectiveness of nutritional interventions addressed to elderly persons: umbrella systematic review with meta-analysis.
    Eur J Public Health 2018 Apr;28(2):275-283
    Department of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
    Background: The number of Europeans aged over 65 will double between 2010 and 2060, reaching 30% of the European population. Nutrition is emerging as a key element of healthy life since both obesity and malnutrition are established risk factors for morbidity and disability. The aim of this umbrella review (UR) is to summarize the findings of all current systematic reviews (SRs) and meta-analyzes (MAs) on the effectiveness of nutritional intervention designed to promote healthy aging in older individuals. Read More

    Raspberry ketone protects against isoproterenol-induced myocardial infarction in rats.
    Life Sci 2018 Feb 7;194:205-212. Epub 2017 Dec 7.
    Department of Pharmacology, School of Pharmaceutical Education & Research (SPER), Jamia Hamdard, New Delhi 110062, India. Electronic address:
    Aim: The cardioprotective role of raspberry ketone (RK) against isoproterenol (ISO)-induced myocardial infarction (MI) in rats was assessed.

    Materials And Methods: Rats were randomly divided into Group I - Vehicle control; Group II - Toxic control ISO (85mg/kg, s.c. Read More

    Successful treatment of facial milia in an infant with orofaciodigital syndrome type 1.
    Pediatr Dermatol 2018 Jan 3;35(1):e88-e89. Epub 2017 Dec 3.
    Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC.
    We report the successful treatment of multiple facial milia with manual extraction and tretinoin in a child with orofaciodigital syndrome type 1. Treatment with topical medications may be insufficient in individuals with orofaciodigital syndrome type 1, and pitted scarring is often a sequala. This case demonstrates that manual extraction is well tolerated and effective in the treatment of multiple milia. Read More

    Interventions targeting loneliness and social isolation among the older people: An update systematic review.
    Exp Gerontol 2018 Feb 2;102:133-144. Epub 2017 Dec 2.
    Section of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
    This systematic review aims to summarize and update the current knowledge on the effectiveness of the existing interventions for alleviating loneliness and social isolation among older persons. A search of PubMed, ISI Web of science, SCOPUS, The Cochrane Library, and CINAHL databases was performed. The terminology combined all possible alternatives of the following keywords: social isolation, loneliness, old people, intervention and effectiveness. Read More

    The role of adhesive materials and oral biofilm in the failure of adhesive resin restorations.
    Am J Dent 2017 Oct;30(5):285-292
    Department of Biomedical Science, University of Sassari, Sassari, Italy.
    Purpose: To critically discuss adhesive materials and oral cariogenic biofilm in terms of their potential relevance to the failures of adhesive restorations in the oral environment.

    Methods: The literature regarding adhesive restoration failures was reviewed with particular emphasis on the chemistry of adhesive resins, weakness in dentin bonding, water fluids, cariogenic oral biofilm and the relations that influence failures. Particular attention was paid to evidence derived from clinical studies. Read More

    Metaboreflex-mediated hemodynamic abnormalities in individuals with coronary artery disease without overt signs or symptoms of heart failure.
    Am J Physiol Heart Circ Physiol 2018 Mar 10;314(3):H452-H463. Epub 2017 Nov 10.
    Department of Medical Sciences and Public Health, University of Cagliari , Cagliari , Italy.
    This study was devised to investigate the effect of coronary artery disease (CAD) without overt signs of heart failure on the cardiovascular responses to muscle metaboreflex activation. We hypothesized that any CAD-induced preclinical systolic and/or diastolic dysfunction could impair hemodynamic response to the metaboreflex test. Twelve men diagnosed with CAD without any sign or symptoms of heart failure and 11 age-matched healthy control (CTL) subjects participated in the study. Read More


    Workplace health promotion programs for older workers in Italy.
    Med Lav 2017 Oct 27;108(5):6229. Epub 2017 Oct 27.
    Università Cattolica del Sacro Cuore, Roma.
    Background: Italy is the European country with the highest number of citizens over the age of sixty. In recent years, the unsustainability of the social security system has forced the Italian government to raise the retirement age and reduce the chances of early exit, thus sharply increasing the age of the workforce. Consequently, a significant proportion of older workers are currently obliged to do jobs that were designed for young people. Read More

    Environmental Pollution by Benzene and PM and Clinical Manifestations of Systemic Sclerosis: A Correlation Study.
    Int J Environ Res Public Health 2017 Oct 26;14(11). Epub 2017 Oct 26.
    Institute of Public Health-Hygiene Section, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.
    Atmospheric air pollution has been associated with a range of adverse health effects. The environment plays a causative role in the development of Systemic Sclerosis (SSc). The aim of the present study is to explore the association between particulate (PM) and benzene (B) exposure in Italian patients with systemic sclerosis and their clinical characteristics of the disease. Read More

    Dental pulp regeneration via cell homing.
    Int Endod J 2018 Apr 7;51(4):405-419. Epub 2017 Nov 7.
    Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
    The typical treatment for irreversibly inflamed/necrotic pulp tissue is root canal treatment. As an alternative approach, regenerative endodontics aims to regenerate dental pulp-like tissues using two possible strategies: cell transplantation and cell homing. The former requires exogenously transplanted stem cells, complex procedures and high costs; the latter employs the host's endogenous cells to achieve tissue repair/regeneration, which is more clinically translatable. Read More

    Eruptive milia during isotretinoin therapy.
    Pediatr Dermatol 2017 Nov 21;34(6):728-729. Epub 2017 Sep 21.
    Department of Dermatology, Children's National Health System, Washington, DC, USA.
    Isotretinoin (13-cis-retinoic acid) is a synthetic vitamin A derivative that is effective in the treatment of recalcitrant, nodulocystic acne. To our knowledge, there are no reports in the medical literature of milia as a side effect of isotretinoin. We report a case of eruptive facial milia in the setting of isotretinoin treatment for acne. Read More

    Thoracic irrigation prevents retained hemothorax: A prospective propensity scored analysis.
    J Trauma Acute Care Surg 2017 Dec;83(6):1136-1141
    From the Division of Trauma and Critical Care, Department of Surgery (N.W.K., T.W.C., D.M.), Medical College of Wisconsin, Milwaukee, WI; and Division of General Surgery, Department of Surgery (J.S.P.), University of New Mexico, Albuquerque, NM.
    Background: Thoracic trauma resulting in hemothorax (HTx) is typically managed with thoracostomy tube (TT) placement; however, up to 20% of patients develop retained HTx which may necessitate further intervention for definitive management. Although optimal management of retained HTx has been extensively researched, little is known about prevention of this complication. We hypothesized that thoracic irrigation at the time of TT placement would significantly decrease the rate of retained HTx necessitating secondary intervention. Read More

    A prospective randomized controlled trial to identify the optimal postoperative pain management in shoulder arthroplasty: liposomal bupivacaine versus continuous interscalene catheter.
    J Shoulder Elbow Surg 2017 Oct 24;26(10):1810-1817. Epub 2017 Aug 24.
    Department of Orthopaedic Surgery, Beaumont Health, Taylor, MI, USA.
    Background: Shoulder arthroplasty is the fastest growing joint replacement surgery in the United States, and optimal postoperative pain management is critical to optimize outcomes for these surgeries. Liposomal bupivacaine (LB) has gained popularity for its potential to provide extended postoperative pain relief with possibly fewer side effects. The goal of this study was to assess the impact of LB compared with continuous interscalene nerve block (CISB) in terms of postoperative pain control, outpatient pain scores, and patient-reported and functional outcomes after shoulder arthroplasty surgery. Read More

    [Risk perception and biological parameters related to obesity in a sample population of the city of Rome, Italy: nurses' contribution to supporting health-related decisions].
    Ig Sanita Pubbl 2017 May-Jun;73(3):215-234
    Istituto di Sanità Pubblica, Sezione di Igiene, Università Cattolica del Sacro Cuore, Roma, Italia.
    Introduction: Obesity is a major public health problem because it is a risk factor for various chronic diseases and its incidence is constantly increasing due to changes in diet and lifestyle. In Italy, studies show that 32% of the population aged between 18 and 69 years is overweight and 10% is obese. The aim of this study was to measure the anthropometric characteristics of a sample population of the city of Rome (Italy) and correlate these with dietary habits and socio-demographic characteristics of participants in order to evaluate their specific health and educational needs. Read More

    A "Sacra Rappresentazione" of Saint Apollonia's Martyrdom.
    J Hist Dent 2017 Summer/Fall;65(2):63-72
    Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
    The literary sources of Saint Apollonia's martyrdom and the evolution of Medieval and Renaissance religious drama are presented along with the compendium of a "Sacra Rappresentazione" from Italian Renaissance regarding Saint Apollonia's Martyrdom. Read More

    Immune-checkpoint inhibitors associated with interstitial lung disease in cancer patients.
    Eur Respir J 2017 08 10;50(2). Epub 2017 Aug 10.
    Service de Pneumologie, Hôpital Larrey, Centre Hospitalier Universitaire, Université Paul Sabatier, Toulouse, France
    Immunotherapy is becoming a standard of care for many cancers. Immune-checkpoint inhibitors (ICI) can generate immune-related adverse events. Interstitial lung disease (ILD) has been identified as a rare but potentially severe event. Read More

    Park availability and major depression in individuals with chronic conditions: Is there an association in urban India?
    Health Place 2017 Sep 25;47:54-62. Epub 2017 Jul 25.
    Centre for Control of Chronic Conditions, Gurgaon, India; Centre for Chronic Disease Control, Gurgaon, India; Public Health Foundation of India, Gurgaon, India; London School of Hygiene&Tropical Medicine, UK. Electronic address:
    Green space exposure has been positively correlated with better mental-health indicators in several high income countries, but has not been examined in low- and middle-income countries undergoing rapid urbanization. Building on a study of mental health in adults with a pre-existing chronic condition, we examined the association between park availability and major depression among 1208 adults surveyed in Delhi, India. Major depression was measured using the Mini International Neuropsychiatric Interview. Read More

    Association between full service and fast food restaurant density, dietary intake and overweight/obesity among adults in Delhi, India.
    BMC Public Health 2017 07 19;18(1):36. Epub 2017 Jul 19.
    Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
    Background: The food environment has been implicated as an underlying contributor to the global obesity epidemic. However, few studies have evaluated the relationship between the food environment, dietary intake, and overweight/obesity in low- and middle-income countries (LMICs). The aim of this study was to assess the association of full service and fast food restaurant density with dietary intake and overweight/obesity in Delhi, India. Read More

    Peritoneal Equilibration Test Reference Values Using a 3.86% Glucose Solution During the First Year of Peritoneal Dialysis: Results of a Multicenter Study of a Large Patient Population.
    Perit Dial Int 2017 Nov-Dec;37(6):633-638. Epub 2017 Jul 11.
    Nephrology and Dialysis Department, Civile Hospital, Vimercate, Italy.
    Background: The original peritoneal equilibration test (PET) was used to classify peritoneal dialysis (PD) patients using a 2.27% glucose solution. It has since been suggested that a 3. Read More

    [Charges and convictions of psychiatrists for the violent behavior of the patient: psychiatric-forensic remarks].
    Riv Psichiatr 2017 May-Jun;52(3):101-108
    Clinica Psichiatrica, Università di Sassari.
    Purpose of the present study is to point-out a number of psychiatric-forensic remarks about the management of violent behavior against the person (VBP) amongst psychiatric patients. The study is the authors' personal contribution based on clinical and forensic experience as experts in the management of psychiatric patients with VBP. Twelve psychiatric-forensic remarks have been highlighted in the present study: 1) VBP is a multifactorial event; 2) the risk of VBP against the person may change rapidly over time in quantity and quality; 3) there are no methods for reliable prediction of VBP in a single clinical-case; 4) there are no medications with an indication of "heal" the VBP; 5) there are no therapeutic measures that neutralize always, quickly and without recurrences VBP; 6) there exist clinical hypotheses to assess VBP; 7) there exist principles of victimology to assess VBP; 8) there are emotional reactions that can affect the evaluation and clinical and forensic management of VBP; 9) the responsibility of the psychiatrist has to be evaluated at the moment of the events; 10) the responsibility of the psychiatrist must be contextualized in the single clinical-case; 11) there is the need to clarify the individual professional responsibility of psychiatrists who treated a patient; 12) there is the need to clarify the criteria for the definition of the guarantee role. Read More

    Eruptive Milia Within a Tattoo: A Case Report and Review of the Literature.
    J Drugs Dermatol 2017 Jun;16(6):621-624

    Of the many tattoo reactions the most common are allergic, granulomatous, lichenoid, photosensitive, pseudolymphomatous, and infectious. Eruptive milia are a rare complication with only three prior reports in the English literature. A 19-year-old African American female presented with tiny, white papules confined within the margins of a tattoo. Read More


    Detectable cerebrospinal fluid JCV DNA in late-presenting HIV-positive patients: beyond progressive multifocal leukoencephalopathy?
    J Neurovirol 2017 Oct 5;23(5):763-767. Epub 2017 Jul 5.
    Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Amedeo di Savoia Hospital, C.so Svizzera 164, 10149, Turin, Italy.
    In the absence of effective prophylaxis and treatment, therapeutic options in HIV-positive patients with progressive multifocal leukoencephalopathy (PML) are limited to antiretroviral therapy: nevertheless, outcome is poor. We conducted a retrospective study (2009-2015) describing the outcome of 25 HIV-positive patients with detectable cerebrospinal fluid JC virus DNA: 14 had a probable PML while the others had evidence of other inflammatory central nervous system (CNS) affecting disorders. In the former group, 6-month mortality was 45. Read More

    Advances in new psychoactive substances identification: the U.R.I.To.N. Consortium.
    J Enzyme Inhib Med Chem 2017 Dec;32(1):841-849
    b Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Polo Scientifico , Università degli Studi di Firenze , Sesto Fiorentino, Florence , Italy.
    Identification of new psychoactive substances (NPS) in biological and non-biological samples represents a hard challenge for forensic toxicologists. Their great chemical variety and the speed with which new NPS are synthesised and spread make stringent the need of advanced tools for their detection based on multidisciplinary approaches. For this reason, in August 2016, the "Unit of Research and Innovation in Forensic Toxicology and Neuroscience of Addiction" (U. Read More

    Total hip prosthesis complication, periprosthetic infection with external fistulizing due to Enterobacter cloacae complex multiple drugs resistance: A clinical case report.
    Int J Surg Case Rep 2017 17;36:90-93. Epub 2017 May 17.
    Department of Orthopaedic, University of Sassari, Sardinia, Italy.
    Introduction: The Enterobacter cloacae is a microorganism found in the intestinal flora of the majority of animals, including humans. Primary infections caused by E. cloacae are rare in immunocompetent patients, but are very common in hospital settings in newborns and immunocompromised patients, and can be aggravated by the insurgence of antibiotic resistance. Read More

    APLASIA CUTIS CONGENITA TYPE I - A CASE SERIES.
    Georgian Med News 2017 Mar(264):7-11
    Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany; Onkoderma - Policlinic of Dermatology and Dermatologic Surgery, Sofia, Bulgaria; Nirvana Skin Clinic, Vadodara, Gujarat, India; Medical Institute of MVR, Department of Dermatology and Venereology, Sofia, Bulgaria; Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.
    Aplasia Cutis Congenita is a rare disorder with circumscribed, partial or widespread absence of skin and subcutaneous soft tissue; in about 20% it also causes skull defects. The disease is heterogeneous in its clinical presentation with nine major subtypes. Type I represents nonsyndromic Aplasia Cutis Congenita. Read More

    Targeting RET in Patients With RET-Rearranged Lung Cancers: Results From the Global, Multicenter RET Registry.
    J Clin Oncol 2017 May 13;35(13):1403-1410. Epub 2017 Mar 13.
    Oliver Gautschi, Kristin Zeidler, and Joachim Diebold, Lucerne Cantonal Hospital, Luzern; Patrizia Froesch, Ente Ospedaliero Cantonale, Bellinzona; Martin Früh, Kantonsspital St Gallen, St Gallen; Sacha I. Rothschild, University Hospital Basel, Basel, Switzerland; Julie Milia and Julien Mazières, Hôpital Larrey; Thomas Filleron, Institut Universitaire du Cancer, Claudius Regaud, Toulouse; Benjamin Besse and Jordi Remon-Masip, Institute Gustave Roussy, Villejuif; Gérard Zalcman, University Hospital Bichat, Paris; Isabelle Monnet, Centre Hospitalier Intercommunal de Creteil, Creteil; Florian Cabillic, Université de Rennes 1, Rennes, France; Juergen Wolf and Sebastian Michels, Center for Integrated Oncology, Cologne; Georg Pall, Fachkliniken Wangen, Wangen Im Allgäu; Arne Warth, Heidelberg University Hospital; Thomas Muley, Thoraxklinik at University of Heidelberg and Translational Lung Research Center, Heidelberg, Germany; David P. Carbone and Dwight Owen, Ohio State University Comprehensive Cancer Center, Columbus; Vamsidhar Velcheti, Cleveland Clinic, Pepper Pike, OH; Ross Camidge and Vignhesh Narayanan, University of Colorado, Denver; Robert C. Doebele, University of Colorado, Aurora, CO; Pasi A. Janne and Mark M. Awad, Dana-Farber Cancer Institute, Boston, MA; Daniel D. Karp, The University of Texas MD Anderson Cancer Center, Houston, TX; Heather A. Wakelee and Joel W. Neal, Stanford University, Stanford; Sai-Hong Ignatius Ou, University of California, Irvine, Orange; David R. Gandara and Jonathan W. Riess, University of California, Davis Cancer Center, Sacramento, CA; Alexander Drilon, Memorial Sloan Kettering Cancer Center, New York, NY; Nir Peled, Davidoff Cancer Center, Petach Tiqwa, Israël; Chul-Cho Byoung, Yonseï Cancer Center, Seoul, Republic of Korea; Michael Van Den Heuvel, Netherlands Cancer Institute, Amsterdam, the Netherlands; Tony S.K. Mok, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China; James C.H. Yang and Jin-Yuan Shih, National Taiwan University Hospital, Taipei, Republic of China; Sanjay Popat, Royal Marsden Hospital, London, United Kingdom; and Rafael Rosell and Niki Karachaliou, Catalan Institute of Oncology, Barcelona, Spain.
    Purpose In addition to prospective trials for non-small-cell lung cancers (NSCLCs) that are driven by less common genomic alterations, registries provide complementary information on patient response to targeted therapies. Here, we present the results of an international registry of patients with RET-rearranged NSCLCs, providing the largest data set, to our knowledge, on outcomes of RET-directed therapy thus far. Methods A global, multicenter network of thoracic oncologists identified patients with pathologically confirmed NSCLC that harbored a RET rearrangement. Read More

    Dermoscopy-pathology relationship in seborrheic keratosis.
    J Dermatol 2017 May;44(5):518-524
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
    Making a definitive diagnosis of seborrheic keratosis (SK) can be challenging for the naked eye due to its wide variation in clinical features. Fortunately, however, most cases of SK exhibit the typical dermoscopic findings of fissures and ridges, hairpin vessels with white halo, comedo-like openings, and milia-like cysts, all of which are helpful to distinguish SK from melanoma, melanocytic nevus, squamous cell carcinoma, basal cell carcinoma (BCC) and other skin tumors. Histopathologically, these dermoscopic characteristics correspond to papillomatous surface of the epidermis, enlarged capillaries of the dermal papillae, pseudohorn cysts in the epidermis opened to the surface of the lesion and intraepidermal cysts, respectively. Read More

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