1,047 results match your criteria Milia


Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR Trial.

Ann Emerg Med 2018 Nov 14. Epub 2018 Nov 14.

Department of Emergency Medicine, University of Texas Health Science Center at Houston, Houston, TX.

Study Objective: The transfusion of older packed RBCs may be harmful in critically ill patients. We seek to determine the association between packed RBC age and mortality among trauma patients requiring massive packed RBC transfusion.

Methods: We analyzed data from the Pragmatic, Randomized Optimal Platelet and Plasma Ratios trial. Read More

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November 2018
7 Reads

Preputial Grafts: The Forgotten Donor Site.

Ann Plast Surg 2018 Dec;81(6):657-661

From the Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, MA.

Background: The prepuce is an excellent donor site for skin grafts with minimal donor site morbidity. Full-thickness grafts are often required for correction of congenital syndactyly and in burn contractures.

Methods: Preputial skin was used for grafting in 18 children: 5 with burn contractures and 13 with congenital syndactyly. Read More

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December 2018
5 Reads

Epidemiology of intensive care unit-acquired sepsis in Italy: results of the SPIN-UTI network.

Ann Ig 2018 Sep-Oct;30(5 Supple 2):15-21

Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

Background: Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units (ICUs). The main aim of the present study was to describe the epidemiology of ICU-acquired sepsis and related outcomes among patients enrolled in the framework of the Italian Nosocomial Infections Surveillance in ICUs - SPIN-UTI project. Read More

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October 2018
8 Reads

Dermatological aspects of the S2k guidelines on Down syndrome in childhood and adolescence.

J Dtsch Dermatol Ges 2018 Oct;16(10):1289-1295

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology and Diabetology, Saarland University Medical Center, Homburg, Germany.

With an incidence of 1 in 700 births, Down syndrome (DS) is not an uncommon condition. It is associated with various disorders of different organ systems. Serious disorders include cardiac defects and leukemia. Read More

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October 2018
3 Reads

Dermatologische Aspekte aus der S2k-Leitlinie zum Down-Syndrom im Kindes- und Jugendalter.

J Dtsch Dermatol Ges 2018 Oct;16(10):1289-1296

Universität des Saarlandes, Kliniken für Kinder- und Jugendmedizin, Sektion Pädiatrische Endokrinologie und Diabetologie, Homburg.

Das Down-Syndrom (DS) ist mit einer Inzidenz von 1 : 700 aller Geburten nicht selten und mit diversen Erkrankungen unterschiedlicher Organsysteme assoziiert. Zu den schwerwiegenden Erkrankungen zählen Herzfehler und Leukämie. Letztere zeigt sich im Neugeborenenalter und geht nicht immer in eine klassische myeloische Leukämie über (transiente myeloproliferative Erkrankung). Read More

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October 2018
3 Reads

Basan gets a new fingerprint: Mutations in the skin-specific isoform of SMARCAD1 cause ectodermal dysplasia syndromes with adermatoglyphia.

Am J Med Genet A 2018 Nov 5;176(11):2451-2455. Epub 2018 Oct 5.

Division of Dermatology, Children's National Health System, Washington, District of Columbia.

Basan syndrome is an autosomal dominant ectodermal dysplasia (ED) with congenital adermatoglyphia, transient neonatal acral bullae, and congenital facial milia. Autosomal dominant adermatoglyphia (ADG) is characterized as adermatoglyphia with hypohidrosis. Recently mutations in the skin-specific isoform of the gene SMARCAD1 have been found in both syndromes. Read More

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November 2018
3 Reads

Retrospective assessment of specific effects of exposure of workers to PCBs in Slovakia.

Ann Agric Environ Med 2018 Sep 9;25(3):421-427. Epub 2018 Apr 9.

1st Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University, Prague, Czech Republic.

Introduction And Objective: Polychlorinated biphenyls (PCBs) have been used commercially since 1929 as dielectric and insulating non-flammable substances, additives for paints, etc. In Slovakia, 60 chemical production workers highly exposed to PCBs (mainly to Delor 103) were studied with duration of exposure ranging from 3 months to 19 years.

Material And Methods: Clinical examinations of skin, skin histology and laboratory tests concerning lipid metabolism, iron metabolism and levels of copper provided comparisons with a control group of healthy individuals and/or the upper limits of normal values. Read More

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September 2018
1 Read

Elevated Syndecan-1 after Trauma and Risk of Sepsis: A Secondary Analysis of Patients from the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial.

J Am Coll Surg 2018 Dec 21;227(6):587-595. Epub 2018 Sep 21.

Center for Translational Injury Research, University of Texas Health Science Center, Houston, TX; Department of Surgery, McGovern Medical School, University of Texas Health Science Center, Houston, TX.

Background: Endotheliopathy of trauma is characterized by breakdown of the endothelial glycocalyx. Elevated biomarkers of endotheliopathy, such as serum syndecan-1 (Synd-1) ≥ 40 ng/mL, have been associated with increased need for transfusions, complications, and mortality. We hypothesized that severely injured trauma patients who exhibit elevated Synd-1 levels shortly after admission have an increased likelihood of developing sepsis. Read More

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December 2018
1 Read

Proactive drugs in DFSA cases: Toxicological findings in an eight-years study.

Forensic Sci Int 2018 Oct 31;291:207-215. Epub 2018 Aug 31.

Forensic Toxicology Unit, Department of Health Sciences, University of Florence, Largo Brambilla 3, Florence, Italy; U.R.I.To.N-Unit of Research of University of Florence, Florence, Italy.

In case of drug-facilitated sexual assault (DFSA), the evidence is frequently anecdotal, with few investigations based on scientific evidences being carried out and thus most cases are diagnosed as an acute drug or alcohol intoxication. The reason may lay in the lack of specific knowledge by the victim on the possibility to retrospectively study the allegedly events and to the absence of standardized and shared protocols among health, forensic and police subjects. On this basis, in 2015 the Unit of Forensic Toxicology of University of Florence and the Sexual Assaults Centre in Hospital Careggi have fixed a common protocol to be applied in case of DFSA. Read More

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October 2018
15 Reads

[Toxicity of immune checkpoints inhibitors].

Rev Mal Respir 2018 Sep 10. Epub 2018 Sep 10.

Service de pneumologie, hôpital Larrey, centre hospitalier universitaire, université Paul-Sabatier, 31059 Toulouse, France. Electronic address:

Introduction: Anti-tumoral immunotherapy is currently the basis of a profound modification of therapeutic concepts in oncology, in particular since the arrival of immune checkpoint inhibitors (ICI). In addition to their efficacy profile, these immune-targeted agents also generate adverse events. With the increasing use of ICI for a growing number of tumor types, awareness of immunotherapy-related adverse events is essential to ensure prompt diagnosis and effective management of these potentially serious adverse events. Read More

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September 2018
3 Reads

Milia-like idiopathic calcinosis cutis and plaque-type syringoma in a girl with Down syndrome.

J Dermatol 2018 Sep 8. Epub 2018 Sep 8.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

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September 2018
13 Reads

Laser Ablation of the Recipient Area With Platelet-Rich Plasma-Enriched Epidermal Suspension Transplant in Vitiligo Surgery: A Pilot Study.

Dermatol Surg 2018 Aug 27. Epub 2018 Aug 27.

All authors are affiliated with the Department of Dermatology, Aesthetic Surgery, and Intervention Dermatology, Aura Skin Institute, Chandigarh, India.

Background: Noncultured epidermal cell suspension transplantation is a very popular surgical modality for treating vitiligo. However, the procedure can be modified to improve results.

Objective: To study the extent of repigmentation with noncultured trypsinized fragmented epidermal suspension using platelet-rich plasma (PRP) as a suspending agent and pixel erbium yttrium aluminium garnet laser for ablation of recipient area in patients with stable vitiligo. Read More

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August 2018
2 Reads

Health promotion for the aging workforce in Poland.

Int J Occup Med Environ Health 2018 Aug 3. Epub 2018 Aug 3.

National Institute of Health, Roma, Italy.

Objectives: The aging of the workforce is an issue that calls for concrete measures to promote the health of older workers. This study reports on the results of the European "ProHealth65+" research project interventions conducted in Poland in relation to workplace health promotion for older workers (WHPOW) and the institutions involved in these programs.

Material And Methods: A three-stage search of peer-reviewed and grey literature on the WHPOW in Poland. Read More

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[Practical approach to patient therapy affected by Autosomal Dominant Autosomic Polycystic Kidney Disease].

G Ital Nefrol 2018 Jul;35(4)

Divisione di Nefrologia, Dialisi Azienda Ospedaliero Universitaria Policlinico di Modena, Dipartimento Chirurgico, Medico, Odontoiatrico e di Scienze Morfologiche con Interesse Trapiantologico, Oncologico e di Medicina Rigenerativa. Università di Modena e Reggio Emilia, Modena, Italia.

The Autosomal Dominant Polycystic Kidney Disease(ADPKD) is the most frequent renal genetic condition and involves 7 to 10% of subjects undergoing renal replacement therapy. It is estimated that between 24,000 and 34,000 subjects in Italy are affected by this condition. For an illness that has long been neglected due to a lack of treatment options, an attractive treatment possibility is now available: tolvaptan has shown clinical efficacy regarding disease progression in two clinical trials (ADPKD patients with mild renal failure and ADPKD patients with advanced renal failure). Read More

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Thymus essential oil extraction, characterization and incorporation in phospholipid vesicles for the antioxidant/antibacterial treatment of oral cavity diseases.

Colloids Surf B Biointerfaces 2018 Nov 11;171:115-122. Epub 2018 Jul 11.

Dept. of Scienze della Vita e dell'Ambiente, Drug Science Division, University of Cagliari, 09124 Cagliari, Italy.

The aim of the work was to extract, characterize, and formulate Thymus capitatus (Tymbra capitata) essential oil in phospholipid vesicles: liposomes, glycerosomes and Penetration Enhancer-containing Vesicles (PEVs). The steam-distilled essential oil was mainly composed of carvacrol. The oil was mixed with lecithin and water to produce liposomes, or different ratios of water/glycerol or water/propylene glycol (PG) to produce glycerosomes and PG-PEVs, respectively. Read More

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November 2018
11 Reads

Frequency of Brain Metastases and Multikinase Inhibitor Outcomes in Patients With RET-Rearranged Lung Cancers.

J Thorac Oncol 2018 Oct 11;13(10):1595-1601. Epub 2018 Jul 11.

Department of Medicine, Cantonal Hospital Lucerne, Luzern, Switzerland.

Introduction: In ret proto-oncogene (RET)-rearranged lung cancers, data on the frequency of brain metastases and, in particular, the outcomes of multikinase inhibitor therapy in patients with intracranial disease are not well characterized.

Methods: A global, multi-institutional registry (cohort A, n = 114) and a bi-institutional data set (cohort B, n = 71) of RET-rearranged lung cancer patients were analyzed. Patients were eligible if they had stage IV lung cancers harboring a RET rearrangement by local testing. Read More

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October 2018
23 Reads

Expression analysis of apolipoproteins AI & AIV in hepatocellular carcinoma: A protein-based hepatocellular carcinoma-associated study.

Indian J Med Res 2018 04;147(4):361-368

Department of Medicine, Maulana Azad Medical College, University of Delhi, New Delhi, India.

Background & Objectives: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality. The objective of this study was to find out the differential expression of apolipoproteins (ApoAI and ApoAIV) in HCC and cases of liver cirrhosis and chronic hepatitis (controls) without HCC and to compare ApoAI and ApoAIV expression with alpha-foetoprotein (AFP), the conventional marker in HCC.

Methods: Fifty patients with HCC and 50 controls comprising patients with liver cirrhosis (n=25) and chronic hepatitis (n=25) without HCC were included in this study. Read More

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April 2018
1.660 Impact Factor

Sodium removal by peritoneal dialysis: a systematic review and meta-analysis.

J Nephrol 2018 Jul 5. Epub 2018 Jul 5.

Department of Nephrology, University of Campania "Luigi Vanvitelli", Piazza Miraglia, 80037, Naples, Italy.

Achievement of sodium and fluid balance is considered a major determinant of dialysis adequacy in peritoneal dialysis (PD). However, the contribution of different PD modalities to dialytic sodium removal (DSR) remains ill-defined. We performed a systematic review and meta-analysis to compare DSR by manual (continuous ambulatory PD, CAPD) versus automated PD (APD). Read More

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July 2018
9 Reads

Spontaneous Fluctuations Can Guide Drug Design Strategies for Structurally Disordered Proteins.

Biochemistry 2018 Jul 5;57(28):4206-4213. Epub 2018 Jul 5.

Department of Chemical Sciences , Tata Institute of Fundamental Research , Homi Bhabha Road , Colaba, Mumbai 400005 , India.

Structure-based "rational" drug design strategies fail for diseases associated with intrinsically disordered proteins (IDPs). However, structural disorder allows large-amplitude spontaneous intramolecular dynamics in a protein. We demonstrate a method that exploits this dynamics to provide quantitative information about the degree of interaction of an IDP with other molecules. Read More

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July 2018
12 Reads

Case Report of a 21-Year-Old Man With Epidermolysis Bullosa Acquisita.

J Cutan Med Surg 2018 May/Jun;22(3):356-358

2 Division of Dermatology and Department of Laboratory Medicine & Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Epidermolysis bullosa acquisita (EBA) is a rare acquired type of mechanobullous disease affecting the dermal-epidermal junction (DEJ) of trauma prone acral surfaces. It manifests as tense vesicles, bullae, and milia and typically heals as atrophic hypo- or hyperpigmented scars. Classic noninflammatory mechanobullous EBA typically presents at a mean age of 48 years. Read More

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December 2018
1 Read

Isolation and genome analysis of a lytic Pasteurella multocida Bacteriophage PMP-GAD-IND.

Lett Appl Microbiol 2018 Sep 17;67(3):244-253. Epub 2018 Jul 17.

Division of Veterinary Microbiology & Immunology, FVSc & A.H., Shuhama (Aulesteng), SKUAST-K, Shalimar, India.

Currently used alum precipitated and oil adjuvant vaccines against HS caused by Pasteurella multocida B:2, have side effects and short-lived immunity, leading to regular catastrophic outbreaks in bovines in Asian subcontinent. The need for the development of an improved vaccine with longer immunity and the ability to differentiate between vaccinated and infected is essential. Pasteurella phage isolated in present study belongs to family Siphoviridae. Read More

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September 2018
8 Reads
1.660 Impact Factor

Pigmented transverse nasal band: A distinct presentation.

J Cosmet Dermatol 2018 May 28. Epub 2018 May 28.

Skin Disease Centre, Nashik, India.

Pigmented transverse nasal band (PTNB) is an interesting morphological entity mainly of cosmetic concern. It is believed to be related to a defect in the development of the nasal cartilages and bones from childhood to adolescence. Some patients may have genetic predisposition. Read More

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May 2018
20 Reads

Bazex-Dupré-Christol syndrome: review of clinical and molecular aspects.

Int J Dermatol 2018 Sep 28;57(9):1102-1106. Epub 2018 May 28.

Consultant Dermatologist, Salmaniya Medical Complex, Manama, Bahrain.

Bazex-Dupré-Christol syndrome is a rare genodermatosis that manifests with the classical triad of basal cell carcinoma, follicular atrophoderma, and hypotrichosis; yet it may be accompanied by milia, ichthyosis, neurological symptoms, and visceral malignancies. Symptom onset is nonsimultaneous, and hence the diagnosis is often made late and the opportunity of counseling and following up is missed. This article aims toward providing a comprehensive review of the clinical perspective of Bazex-Dupré-Christol syndrome, highlighting the major clinical variants to facilitate reaching a prompt diagnosis. Read More

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September 2018
6 Reads

Porphyria cutanea tarda presenting as milia and blisters.

CMAJ 2018 May;190(20):E623

Faculty of Medicine, University of Ottawa, Ottawa, Ont.

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May 2018
2 Reads

Haemodialysis or haemodiafiltration: that is the question.

Nephrol Dial Transplant 2018 Nov;33(11):1896-1904

Department of Nephrology and Dialysis, Alessandro Manzoni Hospital ASST Lecco, Lecco, Italy.

Despite the technological and pharmacological advancements in the last 30 years, morbidity and mortality of dialysis patients are still astonishingly high. Today, convective treatments, such as high-flux haemodialysis (hf-HD) and haemodiafiltration (HDF), are established techniques; the online production of fresh pure dialysate has provided clinical and economic advantages. Nevertheless, the actual benefits of HDF, even with high-convective-volume treatments, are still debatable. Read More

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November 2018
5 Reads

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 Mar;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Read More

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March 2018
37 Reads
2 Citations
15.050 Impact Factor

Milia: An Uncommon Reaction to Photodynamic Therapy.

Actas Dermosifiliogr 2018 Mar 13. Epub 2018 Mar 13.

Servicio de Dermatología, Hospital de la Sant Creu i Sant Pau, Barcelona, España.

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March 2018
4 Reads

Idiopathic multiple eruptive milia: Report of a case in a nigerian woman.

Authors:
H Yahya

Niger J Clin Pract 2018 Mar;21(3):395-396

Dermatology Unit, Department of Medicine, Barau Dikko Teaching Hospital, Kaduna, Nigeria.

Milia are multiple, small, benign keratin-filled superficial epidermoid cysts which are classified as primary when they occur spontaneously or secondary when they result from skin trauma or disease. Multiple eruptive milia (MEM) refer to a condition characterized by a sudden eruption of a large number of milia. MEM may be familial, occur as part of a genodermatosis, or occur spontaneously when they are termed idiopathic. Read More

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March 2018
4 Reads

Dermoscopic features of Milia-Like calcinosis cutis.

G Ital Dermatol Venereol 2018 Mar 6. Epub 2018 Mar 6.

Dermatology Unit "Daniele Innocenzi", Dept of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Fiorini Hospital, Polo Pontino, Terracina, Italy -

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March 2018
5 Reads

[Porphyria cutanea tarda as extrahepatic manifestation of chronic hepatitis C: a case report].

Rev Gastroenterol Peru 2017 Oct-Dec;37(4):394-398

Facultad de Medicina, Universidad Peruana Cayetano Heredia. Lima, Perú.

The present case is a 56 year old male who present hyperpigmented and hypopigmented scars in both hands, associated with the presence of milia cysts. It was studied the metabolism of porphyrins and skin biopsy of the lesions which were compatible with porphyria cutanea tarda. In the initial laboratory, elevated transaminases values were found and subsequently identified chronic infection of hepatitis C virus. Read More

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September 2018
6 Reads

Laboratory findings in Zika infection: The experience of a reference centre in North-West Italy.

J Clin Virol 2018 04 31;101:18-22. Epub 2018 Jan 31.

Laboratory of Microbiology and Virology, Amedeo di Savoia Hospital, Turin, Italy.

Background: Zika virus (ZIKV) remains a public health concern due to its association with fetal malformation and neurologic disease.

Objective: To report a reference centre experience on ZIKA virus (ZIKV) infection in travelers from epidemic countries from January 1 to September, 30, 2016 in Italy North-West (a geographic area covering 4.424 million inhabitants, corresponding to almost 73% of Italy North-West area). Read More

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April 2018
6 Reads

[Trazodone prolonged release in bipolar disorder II-obsessive-compulsive disorder comorbidity: a case report].

Riv Psichiatr 2017 Nov-Dec;52(6):255-257

Clinica Psichiatrica Universitaria di Sassari-Dipartimento di Medicina Clinica e Sperimentale-AOU Sassari.

Approximately 21% of patients with bipolar disorder (BD) also have an additional diagnosis of obsessive-compulsive disorder (OCD). This condition is associated with a more severe prognosis and complicates the treatment of BD. In our case report we provide documentary evidence of our experience with trazodone prolonged release in the treatment of depressive phase in a patient with BD II-OCD comorbidity. Read More

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August 2018
1 Read

Hemodynamic Responses during Enduro-Motorcycling Performance.

Front Physiol 2017 14;8:1062. Epub 2017 Dec 14.

Department of Medical Science and Public Health, Sports Physiology Laboratory, University of Cagliari, Cagliari, Italy.

Much of the information available in the literature on physiological responses during Enduro motorcycling is related to heart rate (HR) and blood lactate (BLa). The aim of this work was to investigate the hemodynamic changes that occur during a 10-min session of Enduro motorcycling. Fifteen skilled riders were enrolled on the study and all participants underwent an Enduro-motorcycling session on a standard track. Read More

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December 2017
4 Reads

Wood's lamp-induced fluorescence of milia.

J Am Acad Dermatol 2018 05 27;78(5):e99-e100. Epub 2017 Dec 27.

Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea. Electronic address:

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May 2018
12 Reads

Heterozygous Deletion Impacting SMARCAD1 in the Original Kindred with Absent Dermatoglyphs and Associated Features (Baird, 1964).

J Pediatr 2018 Mar 18;194:248-252.e2. Epub 2017 Dec 18.

Section of Dermatology, Department of Pediatrics, The Children's Hospital of Philadelphia and University of Pennsylvania Perlman School of Medicine, Philadelphia, PA. Electronic address:

In 1964, Baird described a family with adermatoglyphia, facial milia, and skin fragility. Using whole exome sequencing, genotyping, and Sanger sequencing, we identified a 116-kb heterozygous deletion involving exons 1-9 of SMARCAD1 in descendants of this kindred. This contrasts with point mutations within exon 9 in all other reported families. Read More

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March 2018
5 Reads

Pretibial dystrophic epidermolysis bullosa.

An Bras Dermatol 2017 ;92(5 Suppl 1):126-128

Department of Dermatopathology of the Department of Anatomic Pathology, Santa Casa de Misericórdia de São Paulo - São Paulo (SP), Brazil.

Epidermolysis bullosa is a group of mechano-bullous genetic disorders caused by mutations in the genes encoding structural proteins of the skin. Dystrophic epidermolysis bullosa is caused by mutations in the COL7A1 gene encoding collagen VII, the main constituent of anchoring fibrils. In this group, there are autosomal dominant and recessive inheritances. Read More

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March 2018
4 Reads

Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patient.

An Bras Dermatol 2017 ;92(5 Suppl 1):34-36

Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China.

Bullous pemphigoid is a blistering autoimmune disease characterized by two hemidesmosomal proteins (anti-BP180 and 230). Pemphigus, by contrast, is characterized by two autoantibodies (anti-desmoglein 1 and 3). Coexistence of autoantibodies of bullous pemphigoid and pemphigus in a patient is rare. Read More

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March 2018
8 Reads

Effectiveness of nutritional interventions addressed to elderly persons: umbrella systematic review with meta-analysis.

Eur J Public Health 2018 04;28(2):275-283

Department of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.

Background: The number of Europeans aged over 65 will double between 2010 and 2060, reaching 30% of the European population. Nutrition is emerging as a key element of healthy life since both obesity and malnutrition are established risk factors for morbidity and disability. The aim of this umbrella review (UR) is to summarize the findings of all current systematic reviews (SRs) and meta-analyzes (MAs) on the effectiveness of nutritional intervention designed to promote healthy aging in older individuals. Read More

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April 2018
8 Reads

Raspberry ketone protects against isoproterenol-induced myocardial infarction in rats.

Life Sci 2018 Feb 7;194:205-212. Epub 2017 Dec 7.

Department of Pharmacology, School of Pharmaceutical Education & Research (SPER), Jamia Hamdard, New Delhi 110062, India. Electronic address:

Aim: The cardioprotective role of raspberry ketone (RK) against isoproterenol (ISO)-induced myocardial infarction (MI) in rats was assessed.

Materials And Methods: Rats were randomly divided into Group I - Vehicle control; Group II - Toxic control ISO (85mg/kg, s.c. Read More

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February 2018
5 Reads

Successful treatment of facial milia in an infant with orofaciodigital syndrome type 1.

Pediatr Dermatol 2018 Jan 3;35(1):e88-e89. Epub 2017 Dec 3.

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC.

We report the successful treatment of multiple facial milia with manual extraction and tretinoin in a child with orofaciodigital syndrome type 1. Treatment with topical medications may be insufficient in individuals with orofaciodigital syndrome type 1, and pitted scarring is often a sequala. This case demonstrates that manual extraction is well tolerated and effective in the treatment of multiple milia. Read More

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January 2018
2 Reads

Interventions targeting loneliness and social isolation among the older people: An update systematic review.

Exp Gerontol 2018 02 2;102:133-144. Epub 2017 Dec 2.

Section of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.

This systematic review aims to summarize and update the current knowledge on the effectiveness of the existing interventions for alleviating loneliness and social isolation among older persons. A search of PubMed, ISI Web of science, SCOPUS, The Cochrane Library, and CINAHL databases was performed. The terminology combined all possible alternatives of the following keywords: social isolation, loneliness, old people, intervention and effectiveness. Read More

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February 2018
25 Reads

The role of adhesive materials and oral biofilm in the failure of adhesive resin restorations.

Am J Dent 2017 Oct;30(5):285-292

Department of Biomedical Science, University of Sassari, Sassari, Italy.

Purpose: To critically discuss adhesive materials and oral cariogenic biofilm in terms of their potential relevance to the failures of adhesive restorations in the oral environment.

Methods: The literature regarding adhesive restoration failures was reviewed with particular emphasis on the chemistry of adhesive resins, weakness in dentin bonding, water fluids, cariogenic oral biofilm and the relations that influence failures. Particular attention was paid to evidence derived from clinical studies. Read More

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October 2017
10 Reads

Transverse nasal crease with milia and comedones: Dermoscopic observation.

J Dermatol 2018 May 23;45(5):e126-e127. Epub 2017 Nov 23.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

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May 2018
2 Reads

Metaboreflex-mediated hemodynamic abnormalities in individuals with coronary artery disease without overt signs or symptoms of heart failure.

Am J Physiol Heart Circ Physiol 2018 03 10;314(3):H452-H463. Epub 2017 Nov 10.

Department of Medical Sciences and Public Health, University of Cagliari , Cagliari , Italy.

This study was devised to investigate the effect of coronary artery disease (CAD) without overt signs of heart failure on the cardiovascular responses to muscle metaboreflex activation. We hypothesized that any CAD-induced preclinical systolic and/or diastolic dysfunction could impair hemodynamic response to the metaboreflex test. Twelve men diagnosed with CAD without any sign or symptoms of heart failure and 11 age-matched healthy control (CTL) subjects participated in the study. Read More

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March 2018
19 Reads

Workplace health promotion programs for older workers in Italy.

Med Lav 2017 10 27;108(5):396-405. Epub 2017 Oct 27.

Università Cattolica del Sacro Cuore, Roma.

Background: Italy is the European country with the highest number of citizens over the age of sixty. In recent years, the unsustainability of the social security system has forced the Italian government to raise the retirement age and reduce the chances of early exit, thus sharply increasing the age of the workforce. Consequently, a significant proportion of older workers are currently obliged to do jobs that were designed for young people. Read More

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October 2017
10 Reads

Environmental Pollution by Benzene and PM and Clinical Manifestations of Systemic Sclerosis: A Correlation Study.

Int J Environ Res Public Health 2017 10 26;14(11). Epub 2017 Oct 26.

Institute of Public Health-Hygiene Section, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.

Atmospheric air pollution has been associated with a range of adverse health effects. The environment plays a causative role in the development of Systemic Sclerosis (SSc). The aim of the present study is to explore the association between particulate (PM) and benzene (B) exposure in Italian patients with systemic sclerosis and their clinical characteristics of the disease. Read More

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October 2017
6 Reads

Dental pulp regeneration via cell homing.

Int Endod J 2018 Apr 7;51(4):405-419. Epub 2017 Nov 7.

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

The typical treatment for irreversibly inflamed/necrotic pulp tissue is root canal treatment. As an alternative approach, regenerative endodontics aims to regenerate dental pulp-like tissues using two possible strategies: cell transplantation and cell homing. The former requires exogenously transplanted stem cells, complex procedures and high costs; the latter employs the host's endogenous cells to achieve tissue repair/regeneration, which is more clinically translatable. Read More

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April 2018
2 Reads