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J Oral Biol Craniofac Res 2020 Apr-Jun;10(2):171-174. Epub 2020 Apr 17.

Department of Conservative Dentistry and Endodontics, CDER, AIIMS, New Delhi, India.

Oral health is an integral part of general health. There are many oral health issues which are of concern to India, despite having the maximum number of dental schools in the world. Dental caries, oral cancers and periodontal diseases are areas of national oral health concern. Read More

Behav Brain Res 2020 May 29:112716. Epub 2020 May 29.

IRCCS Neuromed, via Atinense 18, 86077, Pozzilli (IS), Italy.

Dopamine (DA) in medial prefrontal cortex is crucial in extinction of aversive or appetitive experiences. Although attention has been mostly focused on the infralimbic area of prefrontal cortex, a role of the prelimbic area has been envisaged pointing to dopamine transmission in the extinction of drug conditioned behavior. Evidence shows that DA exerts its action also via both D1 and D2 receptor subtypes. Read More

Front Physiol 2020 14;11:397. Epub 2020 May 14.

Sports Physiology Laboratory, University of Cagliari, Cagliari, Italy.

The hemodynamic response to muscle metaboreflex has been reported to be significantly altered by metabolic syndrome (MS), with exaggerated systemic vascular resistance (SVR) increments and reduced cardiac output (CO) in comparison to healthy controls (CTLs). Moreover, patients with metabolic disorders, such as type 2 diabetes, have proven to have impaired cerebral blood flow in response to exercise. Thus, we hypothesized that contemporary mental task (MT) and metaboreflex would result in reduced cerebral oxygenation (COX) in these patients. Read More

Antibiotics (Basel) 2020 May 26;9(6). Epub 2020 May 26.

Department of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010 Bern, Switzerland.

Background: Given the increasing request for natural pharmacological molecules, this study assessed the antimicrobial capacity of Pistacia lentiscus L. essential oil (PLL-EO) obtained from the leaves of wild plants growing in North Sardinia (Italy) toward a wide range of periodontal bacteria and including laboratory and clinical isolates sp., together with its anti-inflammatory activity and safety. Read More

J Cutan Pathol 2020 May 27. Epub 2020 May 27.

Dermatopathology Bodensee, Friedrichshafen, Germany.

Lichen planus follicularis tumidus (LPFT) is a rare clinico-pathological variant of lichen planus (LP), clinically presenting with red-to-violaceous plaques studded with comedo-like lesions and keratin-filled milia-like cysts. Histopathologically, LPFT is characterized by cystically dilated follicular infundibula in the dermis, surrounded by a dense lichenoid lymphoid infiltrate with an associated interface reaction. We describe the clinico-pathological features of an additional case of LPFT, focusing on number and distribution of CD123(+) TCF4(+) plasmacytoid dendritic cells (pDCs). Read More

J Pediatr 2020 May 8. Epub 2020 May 8.

Azienda USL Toscana Nord Ovest, UOS Dermatologia di Lucca, Lucca, Italy.

Dermatol Res Pract 2020 5;2020:8410165. Epub 2020 May 5.

Department of Pediatrics, Ramsar Campus, Mazandaran University of Medical Sciences, Sari, Iran.

Cutaneous lesions are common in the neonatal period and mostly physiological, transient, and self-limited; uncommonly, they are pathological and require treatment and cooperation between neonatologists and dermatologists. Particular conditions, like prematurity, can influence the onset, type, and evolution of cutaneous manifestations. Of the several articles in the literature about skin findings in newborns, only a few were performed in Iran. Read More

Environ Technol 2020 Jun 2:1-10. Epub 2020 Jun 2.

Institute of Environmental Geology and Geoengineering, National Research Council of Italy, Cagliari, Italy.

Most of nitrogen emissions can be ascribed to agro-industrial activities. Since digestate produced by fermentation of agro-industrial residues can be difficult to dispose of due to its high ammonium content, advanced technical- and cost-effective technologies must be developed and applied in order to significantly reduce its impact on the environment. In this study, aerobic granules were successfully cultivated in a granular sludge sequencing batch reactor (GSBR) fed with the ammonium-rich (approx. Read More

N Biotechnol 2020 Apr 30;58:1-9. Epub 2020 Apr 30.

National Research Council of Italy, Institute of Environmental Geology and Geoengineering (CNR-IGAG), Area della Ricerca Roma 1, Montelibretti, Rome 00015, Italy. Electronic address:

In this study, the anammox process was applied for the first time to the treatment of ammonium-rich liquid residues produced by the two-stage anaerobic digestion of food waste (2sAD-FW); such residues may represent a significant environmental issue if not properly managed. A granular anammox reactor was fed with a progressively increasing share of partially nitritated 2sAD-FW wastewater. An alternative operating strategy based on partial by-pass of the partial nitritation unit was tested, in order to regulate the influent NO/NH molar ratio without chemical addition. Read More

J Nephrol 2020 Apr 15. Epub 2020 Apr 15.

Nephrology and Dialysis Unit, Hospital of Trento, Trento, Italy.

High-technology medicine saves lives and produces waste; this is the case of dialysis. The increasing amounts of waste products can be biologically dangerous in different ways: some represent a direct infectious or toxic danger for other living creatures (potentially contaminated or hazardous waste), while others are harmful for the planet (plastic and non-recycled waste). With the aim of increasing awareness, proposing joint actions and coordinating industrial and social interactions, the Italian Society of Nephrology is presenting this position statement on ways in which the environmental impact of caring for patients with kidney diseases can be reduced. Read More

Clin Kidney J 2020 Apr 8;13(2):253-260. Epub 2019 Nov 8.

Salus Medical Center, Lecco, Italy.

Background: Guidelines indicate that a low-protein diet (LPD) delays dialysis in severe chronic kidney disease (CKD). We assessed the value of these guidelines by performing a retrospective analysis in our renal clinical practice.

Methods: The analysis was performed from 1 January 2010 to 31 March 2018 in 299 CKD Stage 4 patients followed for 70 months in collaboration with a skilled nutritionist. Read More

Euro Surveill 2020 04;25(13)

The members of the CHIKV-Working Group are listed at the end of the article.

We illustrate the potential for specialist laboratory networks to be used as preparedness and response tool through rapid collection and sharing of data. Here, the Emerging Viral Diseases-Expert Laboratory Network (EVD-LabNet) and a laboratory assessment of chikungunya virus (CHIKV) in returning European travellers related to an ongoing outbreak in Thailand was used for this purpose. EVD-LabNet rapidly collected data on laboratory requests, diagnosed CHIKV imported cases and sequences generated, and shared among its members and with the European Centre for Disease Prevention and Control. Read More

Eur Rev Med Pharmacol Sci 2020 Mar;24(5):2710-2718

Digestive Disease Center, Fondazione Policlinico Universitario "A. Gemelli" - IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Objective: Acute uncomplicated diverticulitis is an important clinical condition usually managed in clinical practice with antibiotic therapies and hospitalization in ward. In this setting, recent papers and guidelines suggest to limit the use of antibiotics in selected cases and encourage an early discharge in low-risk patients. The purpose of this retrospective study is to identify serological inflammatory markers and CT findings of acute uncomplicated diverticulitis (AUD) at the onset of the disease and the correlation with the need for in-patient or out-patient management. Read More

J Trauma Acute Care Surg 2020 Mar 14. Epub 2020 Mar 14.

Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, Fax: 414-955-0072, Office: 414-955-1726. Medical College of Wisconsin. Marquette University, Froedtert Lutheran Memorial Hospital. Medical College of Wisconsin. Medical College of Wisconsin. Medical College of Wisconsin.

Background: Little effort has been made to address long-term quality of life (QOL), chronic pain(CP), post-traumatic stress disorder (PTSD), and functional disability in trauma survivors. This quality initiative was developed to determine feasibility of a coordinated, comprehensive, patient-centered follow-up clinic for those at risk for poor long-term outcomes.

Methods: A convenience sample from 649 hospitalized trauma patients at a Midwestern level 1 trauma center between 2/2018 and 8/2018 was screened for risk of PTSD and CP. Read More

Sci Total Environ 2020 Jun 5;721:137766. Epub 2020 Mar 5.

Integrative Ecology Group, Cavanilles Institute for Biodiversity and Evolutionary Biology, University of Valencia, Catedrático José Beltrán 2, E-46980 Paterna, Valencia, Spain.

The contribution of plankton in the performance of three constructed wetlands (CWs) within the Albufera de València Natural Park has been analyzed, taxonomic group by group, over a two-year operation period in the different sectors of each CW: horizontal subsurface-flow -A-, free-water surface flow -B- and lagoons -C-. Tancat de la Pipa CW (TPCW) only contains B-C sectors, while the others have all three types. Treatment efficiency of each sector type on the taxonomic groups was evaluated by calculating frequency of phytoplankton reduction (or zooplankton production), mass removal (or production) efficiencies and rates, and accumulated removed phytoplankton mass (or produced zooplankton mass). Read More

Br J Pharmacol 2020 Mar 10. Epub 2020 Mar 10.

Rottapharm Biotech, Monza, Italy.

Background And Purpose: Prolonged use of opioids causes analgesic tolerance and adverse effects including constipation and dependence. Compounds targeting imidazoline I receptors are known to potentiate opioid analgesia in rodents. We investigated whether combination with the I receptor ligand CR4056 could improve efficacy and safety of morphine and explored the mechanisms of the CR4056-opioid interaction. Read More

Vaccines (Basel) 2020 Feb 13;8(1). Epub 2020 Feb 13.

Section of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

Flu vaccination is recommended among healthcare workers (HCWs). The low vaccination coverage registered in our hospital among HCWs called for new engaging approaches to improve flu vaccination coverage. The aim of this study was to evaluate the efficacy of different strategies implemented during the last four years (2015-2019). Read More

Dermatol Online J 2019 Dec 15;25(12). Epub 2019 Dec 15.

The Laser Skin & Surgery Center of New York, New York, NY New York University Langone Medical Center, The Ronald O. Perelman Department of Dermatology, New York, NY.

Porphyria cutanea tarda (PCT) is the most common type of porphyria, presenting in middle-aged patients with a photodistributed vesiculobullous eruption, milia, and scars. Porphyria cutanea tarda occurs in relation to inhibition of uroporphyrinogen decarboxylase, a key enzyme in the heme biosynthesis pathway. A number of genetic and acquired factors increase susceptibility to PCT by reducing uroporphyrinogen decarboxylase activity. Read More

J Dermatol 2020 Apr 11;47(4):e128-e129. Epub 2020 Feb 11.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Indian J Dermatol Venereol Leprol 2020 May-Jun;86(3):251-261

Department of Dermatology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Background: Benign melanocytic neoplasms have nests of melanocytic cells and show characteristic dermoscopic features. Clinical and dermoscopic features have not been studied previously in the Indian population.

Aims: To study the clinical, epidemiological and dermoscopic patterns of benign melanocytic neoplasms. Read More

Cureus 2019 Dec 15;11(12):e6386. Epub 2019 Dec 15.

Oncologic Dermatology, Elias Emergency University Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.

Epidermolysis bullosa acquisita (EBA) is an autoimmune subepidermal bullous disorder of the skin and mucous membranes. The disease results from the production of immunoglobulin G (IgG) antibodies against type-VII collagen, a major component of anchoring filaments in the dermal-epithelial junction. The disease has two major forms of presentation: the classical (non-inflammatory) type and the inflammatory type. Read More

J Trauma Acute Care Surg 2020 Mar;88(3):416-424

From the Department of Surgery (R.S.M., J.G., J.C., C.J.T.), University of Minnesota, Minneapolis, Minnesota; Department of Surgery (D.M.), Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Surgery (L.M.N., M.R.H.), University of Michigan, Ann Arbor; Department of Surgery (B.C.), University of Minnesota, Minneapolis, Minnestoa; Institute for Health Informatics (E.L., E.K., C.J.T.), University of Minnesota, Minneapolis, Minnesota; Department of Surgery (D.S.), University of California San Francisco, San Francisco, California; Department of Surgery (C.J.T.), North Memorial Health Hospital, Robbinsdale; and Department of Surgery (M.R.H.), Center for Healthcare Outcomes and Policy, University of Michigan, Ann Arbor, Minnesota.

Introduction: Elderly trauma patients are at high risk for mortality, even when presenting with minor injuries. Previous prognostic models are poorly used because of their reliance on elements unavailable during the index hospitalization. The purpose of this study was to develop a predictive algorithm to accurately estimate in-hospital mortality using easily available metrics. Read More

J Water Health 2019 Dec;17(6):845-862

Department of Agricultural Sciences, University of Sassari, Viale Italia 39, 07100 Sassari, Italy E-mail:

The relationship between naturally fluoridated groundwater and dental fluorosis has received large attention from researchers around the world. Despite recognition that several factors influence this relationship, there is a lack of systematic studies analyzing the heterogeneity of these results. To fill such a gap, this study performs a systematic review and meta-analysis to understand which factors influence this relationship and how. Read More

Biomark Res 2019 4;7:28. Epub 2019 Dec 4.

11Hôpital Larrey, Centre Hospitalier Universitaire de Toulouse, 24 Chemin de Pouvourville, 31059 Toulouse, France.

Background: Immunotherapy is currently under investigation in B3 Thymoma (TB3) and Thymic Carcinoma (TC). PD-L1 expression has been evaluated on a limited number of patients with selected antibodies. We aimed to analyze cohort of TB3 and TC with a panel of antibodies to assess the prevalence of PD-L1 expression, its prognostic value and to set up a reproducible test. Read More

Nanomaterials (Basel) 2019 Dec 9;9(12). Epub 2019 Dec 9.

Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.

Background: Calcium phosphate-based compounds are used to treat dental hypersensitivity (DH). Their long-term clinical behaviour needs further research. This study compared the 24-week effectiveness of Teethmate Desensitizer (TD), a pure tetracalcium phosphate (TTCP) and dicalcium phosphate dihydrate (DCPD) powder/water, to that of Dentin Desensitizer (DD), and Bite & White ExSense (BWE), both of calcium phosphate crystallites. Read More

Nat Sci Sleep 2019 8;11:325-332. Epub 2019 Nov 8.

Department of Building and Real Estate, Hong Kong Polytechnic University, Kowloon, Hong Kong Special Administrative Region.

Aims: This study aimed to assess the psychometric properties of the Sleep Hygiene Index (SHI) instrument in screening poor sleep hygiene practices among Saudi university students. As a secondary goal, the association of sleep hygiene practices with stress and anxiety scores were assessed.

Methods: Two-hundred and four healthy college and university students aged 18 to 25 years participated in this cross-sectional questionnaire-based survey. Read More

J Cosmet Dermatol 2020 Jan 29;19(1):102-104. Epub 2019 Nov 29.

Tennessee Clinical Research Center, Nashville, Tennessee.

Background: Idiopathic calcinosis cutis is an uncommon form of calcinosis cutis. It may present as tumoral calcinosis, subepidermal calcified nodules or scrotal calcinosis. Subepidermal calcified nodules may also present as milia-like lesions commonly seen in children with Down's syndrome in the absence of tissue damage or metabolic disorders, it has been seldom reported in adults. Read More

AIDS 2020 03;34(3):373-380

Unit of Infectious Diseases, Department of Medical Sciences, University of Torino.

Objective: The current study aimed to investigate whether cerebrospinal fluid (CSF) Epstein-Barr virus (EBV) or cytomegalovirus (CMV) DNA was associated with viral, inflammatory and neuronal damage biomarkers in people living with HIV (PLWH).

Design: A cross-sectional diagnostic study on CSF fluid samples in patients undergoing lumbar punctures for clinical reasons, to better understand the role of EBV and CMV in the CNS on HIV RNA replication, blood-brain-barrier (BBB) damage and biomarkers of neuronal damage/inflammation.

Methods: EBV, CMV DNA and HIV RNA were measured on CSF, through real time (RT)-PCR, from PLWHs undergoing lumbar punctures for clinical reasons (excluding oncho-haematological comorbidities). Read More

Eur Rev Med Pharmacol Sci 2019 Nov;23(4 Suppl):21-26

Istituto Prosperius Tiberino, Intensive Rehabilitation Centre, Umbertide, Perugia, Italy.

Objective: The treatment of chronic pain frequently combines pharmacologic and non-pharmacological options, and analgesia after surgery is of major importance. Tapentadol is both µ-opioid receptor agonist (with a 40% agonism on these receptors) and noradrenaline reuptake inhibitor, with similar analgesic efficacy to strong opioids, but fewer adverse effects. For these reasons, tapentadol may represent a valuable first choice option in the treatment of chronic, neuropathic, and mixed pain. Read More

Sci Rep 2019 Nov 21;9(1):17517. Epub 2019 Nov 21.

Department of Biophysics, All India Institute of Medical Sciences (AII MS), New Delhi, India.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

Presse Med 2019 Dec 18;48(12):1589-1590. Epub 2019 Nov 18.

Habib Thameur Hospital, Research Unit "Genodermatoses and cancers" LR12SP03, Dermatology Department, Tunis, Tunisia.

J Trauma Acute Care Surg 2020 Feb;88(2):279-285

From the Departments of Surgery, Critical Care Medicine, and the Clinical and Translational Science Institute (CTSI) (M.D.N.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Ernest E Moore Shock Trauma Center at Denver Health (E.E.M.), Denver, Colorado; Memorial Hospital of South Bend (M.W., S.T.), South Bend, Indiana; Department of Surgery (R.A.C., L.Z.K.), Zuckerberg San Francisco General Hospital, University of California San Francisco (UCSF), San Francisco, California; Division of Trauma, Critical Care & Acute Care Surgery, Department of Surgery (M.S.), Oregon Health & Science University, Portland, Oregon; Wright State University (A.P.E.), Dayton, Ohio; Stony Brook Department of Emergency Medicine (A.J.S.), Stony Brook University, Stony Brook, New York; Department of Surgery, Florida Atlantic University, St. Mary's Medical Center (L.L.), West Palm Beach, Florida; Division of Trauma, Acute Care, and Critical Care Surgery (M.F.), Baylor University Medical Center, Dallas, Texas; Division of Acute Care Surgery, Department of Surgery (S.E.), Carolinas Medical Center, Charlotte, North Carolina; University of Kansas Medical Center (R.D.W.), University of Kansas, Kansas City, Kansas; Department of Surgery (M.D.G.), University of Cincinnati, Cincinnati, Ohio; SSM Health (C.F.), Saint Louis University Hospital, St Louis, Missouri; Division of Trauma and Acute Care Surgery (D.M.), Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Surgery (N.S.), Massachusetts General Hospital, Boston; and Haemonetics Corporation (J.H., H.E.A.), Braintree, Massachusetts.

Background: Trauma-induced coagulopathy is a major driver of mortality following severe injury. Viscoelastic goal-directed resuscitation can reduce mortality after injury. The TEG 5000 system is widely used for viscoelastic testing. Read More

J Nephrol 2020 Feb 16;33(1):59-68. Epub 2019 Nov 16.

Nephrology Units at University of Campania "Luigi Vanvitelli", Naples, Italy.

The major trials in peritoneal dialysis (PD) have demonstrated that increasing peritoneal clearance of small solutes is not associated with any advantage on survival, whereas sodium and fluid overload heralds higher risk of death and technique failure. On the other hand, higher sodium and fluid overload due to loss of residual kidney function (RKF) and higher transport membrane is associated with poor patient and technique survival. Recent experimental studies also show that, independently from fluid overload, sodium accumulation in the peritoneal interstitium exerts direct inflammatory and angiogenetic stimuli, with consequent structural and functional changes of peritoneum, while in patients with Chronic Kidney Disease sodium stored in interstitial skin acts as independent determinant of left ventricular hypertrophy. Read More

Clin Oral Investig 2019 Nov 14. Epub 2019 Nov 14.

Department of Conservative and Operative Dentistry, University Hospital Regensburg, Regensburg, Germany.

Objectives: To assess the clinical effectiveness of four desensitizing materials in patients who are xerostomic due to radiotherapy for head and neck cancer (HNC) in comparison to a healthy group with normal salivation.

Methods And Materials: The study was conducted as a split-mouth randomized clinical trial. Forty HNC patients (group A) and 46 healthy patients (group B) suffering from dentin hypersensitivity (DH) were included. Read More

PLoS One 2019 14;14(11):e0225326. Epub 2019 Nov 14.

Università Cattolica del Sacro Cuore, Section of Hygiene - Institute of Public Health, Roma, Italia.

Flu vaccination, as well as being effective to prevent seasonal influenza, decreases staff illness and absenteeism and reduces costs resulting from loss of productivity. Despite the effectiveness of flu vaccination, the seasonal coverage among healthcare workers is usually low. The aim of this retrospective observational study was to analyze the vaccination coverage rate among all employees (healthcare workers and administrative staff) of a large teaching hospital in Rome during the 2017-2018 influenza season, to perform a cost-consequence analysis of influenza vaccination (by evaluating the absenteeism due to illness in the epidemic period), and to assess the impact of vaccination in terms of both costs and sick days. Read More

J Trauma Nurs 2019 Nov/Dec;26(6):290-296

Medical College of Wisconsin, Milwaukee (Drs Trevino, deRoon-Cassini, Carver, and Milia); Dartmouth-Hitchcock Medical Center/Geisel School of Medicine at Dartmouth, Hanover, New Hampshire (Dr Cooros); and Marquette University, Milwaukee, Wisconsin (Ms Chesney).

The objective of this study was to assess the current practice pattern regarding posthospitalization follow-up of trauma patients among the members of the Eastern Association for the Surgery of Trauma (EAST). An anonymous online multiple-choice survey of EAST members in 2016 was conducted. Ten questions relating to the follow-up care of injured patients were presented to the Active, Senior, and Associate members of EAST. Read More

Mediterr J Hematol Infect Dis 2019 1;11(1):e2019062. Epub 2019 Nov 1.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.

Building-work activities could cause dust contamination and fungal spores' dissemination. A significant relationship was found between building-work activities and the incidence of invasive aspergillosis, in profoundly immunocompromised patients. Renovation-works activities were carried out by four building sites of the hematology ward in a Teaching Hospital without the interruption of clinical activities. Read More

Front Immunol 2019 22;10:2466. Epub 2019 Oct 22.

Department of Dermatology, Center for Blistering Diseases, Tufts University School of Medicine, Boston, MA, United States.

The many clinical aspects of anti-p200 pemphigoid are not well-characterized. We aimed to analyze and correlate known existing data on the epidemiological, clinical, histological, and immunological features of anti-p200 pemphigoid. We performed a review using Medline, Embase, and Web of Science databases (1900-2018). Read More

Intern Emerg Med 2019 Oct 30. Epub 2019 Oct 30.

Experimental and Clinical Medicine Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

A 33-year-old man with type 1 diabetes mellitus was admitted to the Internal Medicine Unit due to subacute onset of exertional dyspnea, with evidence at initial blood exams of severe macrocytic anemia with thrombocytopenia, biohumoral signs of hemolysis and 5 schistocytes per magnified field on the blood smear. A thrombotic microangiopathy (TMA) was suspected and plasma exchange (PEX) was started soon, since the risk of a life threatening condition. On the second day, after the results of A Disintegrin And Metalloproteinase with ThromboSpondin-1 motif, member 13 (ADAMTS-13) and reticulocytes were available, a critical reappraisal of the clinical scenario was done. Read More

Indian J Dermatol Venereol Leprol 2019 Oct 22. Epub 2019 Oct 22.

Department of Dermatology, The First Bethune Hospital of Jilin University, Changchun, China.

Australas J Dermatol 2020 May 24;61(2):163-164. Epub 2019 Oct 24.

Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Sci Rep 2019 Oct 9;9(1):14486. Epub 2019 Oct 9.

Inter-University Accelerator Centre, Aruna Asaf Ali Marg, New Delhi, 110067, India.

The SrTiO thin films were fabricated by pulsed laser deposition. Subsequently ion implantation with 60 keV N ions at two different fluences 1 × 10 and 5 × 10 ions/cm and followed by annealing was carried out. Thin films were then characterized for electronic structure, morphology and transport properties. Read More

J Spec Oper Med 2019 ;19(3):117-121

Theater Special Operations Force (SOF) medical planners have been using Army forward surgical teams (FSTs) to maintain a golden hour for US SOF during Operation Freedom's Sentinel in the form of Golden Hour Offset Surgical Treatment Teams (GHOST-Ts) in Afghanistan. Recently, the Special Operations Resuscitation Team (SORT) was designed to decompress and augment a GHOST-T to help extend a golden hour ring in key strategic locations. This article describes both teams working together in Operation Freedom's Sentinel while deployed in support of SOF in central Afghanistan during the summer fighting season. Read More

Mar Drugs 2019 Sep 16;17(9). Epub 2019 Sep 16.

Toxicology and Pharmacology, KU Leuven, Campus Gasthuisberg, O & N2, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium.

The a-Conotoxins are peptide toxins that are found in the venom of marine cone snails and they are potent antagonists of various subtypes of nicotinic acetylcholine receptors (nAChRs). Because nAChRs have an important role in regulating transmitter release, cell excitability, and neuronal integration, nAChR dysfunctions have been implicated in a variety of severe pathologies. We describe the isolation and characterization of α-conotoxin MilIA, the first conopeptide from the venom of The peptide was characterized by electrophysiological screening against several types of cloned nAChRs that were expressed in oocytes. Read More

Comput Biol Chem 2019 Dec 6;83:107120. Epub 2019 Sep 6.

Department of Computer Science, jamia Milia Islamia, New Delhi, India. Electronic address:

Data generation using high throughput technologies has led to the accumulation of diverse types of molecular data. These data have different types (discrete, real, string, etc.) and occur in various formats and sizes. Read More

Br J Pharmacol 2020 Jan 7;177(1):48-64. Epub 2019 Nov 7.

Dipartimento di Economia, Scienze e Diritto, Università degli Studi della Repubblica di San Marino, San Marino.

Background And Purpose: CR4056 is a first-in-class imidazoline-2 (I ) receptor ligand characterized by potent analgesic activity in different experimental animal models of pain. In a recent phase II clinical trial, CR4056 effectively reduced pain in patients with knee osteoarthritis. In the present study, we investigated the effects of CR4056 on PKCε translocation in vitro and on PKCε activation in vivo in dorsal root ganglia (DRG) neurons. Read More

Am J Dermatopathol 2020 Feb;42(2):103-110

Laboratoire Central d'Anatomie Pathologique, Hôpital L. Pasteur, University of Nice, France.

This is a report of a previously undescribed type of onychomatricoma (OM) with an unusual clinical presentation as a thickened free edge of the nail plate without discernible cavities and distinguished histologically from the ordinary OM by 3 features: (1) the lack of cavitation at the proximal border of the nail plate and the small sizes of the cavities at the free edge of the distal nail plate; (2) a papillated epithelial hyperplasia pattern very different from the digitate pattern of the ordinary OM; and (3) a special pattern of matrical keratinization with pseudohorn cysts that mirror closely those found in onychocytic matricoma (OCM). Furthermore, the sex ratio and sites of the lesion seem different than those of conventional OM with the caveat that the numbers in this series are small. A practical approach to the diagnosis of onychogenic tumor mainly involves consideration of tumors that clinically present as localized longitudinal pachyonychia including melanoma and Bowen disease. Read More