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    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Assessment of intradialysis calcium mass balance by single pool variable-volume calcium kinetic model.
    Hemodial Int 2017 Feb 5. Epub 2017 Feb 5.
    Depatments of Nephrology and Dialysis, A. Manzoni Hospital, Lecco, Italy.
    Introduction: A reliable method of intradialysis calcium mass balance quantification is far from been established. We herein investigated the use of a single-pool variable-volume Calcium kinetic model to assess calcium mass balance in chronic and stable dialysis patients.

    Methods: Thirty-four patients on thrice-weekly HD were studied during 240 dialysis sessions. Read More

    Circadian preferences in young adults: Psychometric properties and factor structure of the Portuguese version of the Preferences Scale (PS-6).
    Chronobiol Int 2017 Jan 31:1-8. Epub 2017 Jan 31.
    e Faculty of Medicine, University of Coimbra , Coimbra , Portugal.
    Morningness is a trait-like variable which has been extensively studied within chronobiology. Despite the number of existing measures to assess morningness, there is a need for brief instruments that are psychometrically sound to be used in applied settings. Accordingly, the modified version of the Preferences Scale (PS-6) comprises six items and was reported to have adequate reliability and satisfactory validity indicators. Read More

    The connecting link! Lip prints and fingerprints.
    J Forensic Dent Sci 2016 Sep-Dec;8(3):177
    Department of Orthodontics, Jamia Milia Islamia University, Jamia Nagar, New Delhi, India.
    Background: Lip prints and fingerprints are considered to be unique to each individual. The study of fingerprints and lip prints is very popular in personal identification of the deceased and in criminal investigations.

    Aims: This study was done to find the predominant lip and fingerprint patterns in males and females in the North Indian population and also to find any correlation between lip print and fingerprint patterns within a gender. Read More

    Cilia Control Vascular Mural Cell Recruitment in Vertebrates.
    Cell Rep 2017 Jan;18(4):1033-1047
    Vesalius Research Center, VIB-KUL, Leuven 3000, Belgium; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, Turin 10126, Italy. Electronic address:
    Vascular mural cells (vMCs) are essential components of the vertebrate vascular system, controlling blood vessel maturation and homeostasis. Discrete molecular mechanisms have been associated with vMC development and differentiation. The function of hemodynamic forces in controlling vMC recruitment is unclear. Read More

    Milia may originate from the outermost layers of the hair bulge of the outer root sheath: A case report.
    Oncol Lett 2016 Dec 2;12(6):5190-5192. Epub 2016 Nov 2.
    Department of Pathology, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan.
    It has been hypothesized that milia originate from the hair bulge of the outer root sheath. To elucidate the histogenesis of milia, an immunohistochemical study was performed using anti-keratin and anti-filaggrin antibodies to determine the levels of keratin and filaggrin expression. Keratin expression was evaluated using anti-keratin antibodies against K1, K7, K8, K10, K14, K15, K16, K17, K18, K19 and K20. Read More

    3-MeO-PCP intoxication in two young men: First in vivo detection in Italy.
    Forensic Sci Int 2016 Dec 26. Epub 2016 Dec 26.
    Forensic Toxicology Division, Department of Health Science, University of Florence, Italy. Electronic address:
    3-MeO-PCP or 3-methoxyphencyclidine is a derivative of phencyclidine. It acts as a dissociative anesthetic and it has allegedly hallucinogenic and sedative effects. There are almost no documented intoxication cases and references about its pharmacology and toxicity in literature. Read More

    The peritoneal sieving of sodium: a simple and powerful test to rule out the onset of encapsulating peritoneal sclerosis in patients undergoing peritoneal dialysis.
    J Nephrol 2016 Dec 24. Epub 2016 Dec 24.
    Department of Nephrology and Dialysis, A. Manzoni Hospital, Via dell'Eremo 9/11, 23900, Lecco, Italy.
    Background And Aims: Encapsulating peritoneal sclerosis (EPS) is an uncommon but severe complication of peritoneal dialysis (PD). A reliable screening tool to identify patients at risk of developing or not EPS is currently not available. We aimed to evaluate whether the reduction in dialysate sodium concentration (sodium sieving) at 60 min (ΔDNa60), during a peritoneal equilibration test with 3. Read More

    Multiple Milia as an Isolated Skin Manifestation of Dominant Dystrophic Epidermolysis Bullosa: Evidence of Phenotypic Variability.
    Pediatr Dermatol 2016 Dec 23. Epub 2016 Dec 23.
    Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
    We report a Japanese pedigree with dominant dystrophic epidermolysis bullosa (DDEB) harboring the p.G2251E mutation of COL7A1. The proband of this pedigree presented with multiple milia as an isolated skin manifestation without a history of blistering and subsequently developed generalized intractable blisters, suggesting that multiple milia could be a primary manifestation of DDEB. Read More

    The RAS-related GTPase RHOB confers resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer via an AKT-dependent mechanism.
    EMBO Mol Med 2017 Feb;9(2):238-250
    Inserm, Centre de Recherche en Cancérologie de Toulouse, CRCT UMR-1037, Toulouse, France
    Although lung cancer patients harboring EGFR mutations benefit from treatment with EGFR-tyrosine kinase inhibitors (EGFR-TKI), most of them rapidly relapse. RHOB GTPase is a critical player in both lung carcinogenesis and the EGFR signaling pathway; therefore, we hypothesized that it could play a role in the response to EGFR-TKI In a series of samples from EGFR-mutated patients, we found that low RHOB expression correlated with a good response to EGFR-TKI treatment while a poor response correlated with high RHOB expression (15.3 versus 5. Read More

    High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: a nationwide longitudinal study, 2004-2013.
    Sci Rep 2016 Dec 19;6:38844. Epub 2016 Dec 19.
    Centre of Epidemiology and Biostatistics, Polytechnic University of Marche, Ancona, Italy.
    This longitudinal population-based study analyses the frequency of diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis in Italian children under 15 years of age, during 2004-2013. DKA was defined as absent (pH ≥ 7.30), mild/moderate (7. Read More

    Hemodynamic response to muscle reflex is abnormal in patients with heart failure with preserved ejection fraction.
    J Appl Physiol (1985) 2017 Feb 15;122(2):376-385. Epub 2016 Dec 15.
    Department of Medical Sciences, Sports Physiology Lab., University of Cagliari, Cagliari, Italy; and
    The aim of the present investigation was to assess the role of cardiac diastole on the hemodynamic response to metaboreflex activation. We wanted to determine whether patients with diastolic function impairment showed a different hemodynamic response compared with normal subjects during this reflex. Hemodynamics during activation of the metaboreflex obtained by postexercise muscle ischemia (PEMI) was assessed in 10 patients with diagnosed heart failure with preserved ejection fraction (HFpEF) and in 12 age-matched healthy controls (CTL). Read More

    Haemodiafiltration at Higher Volumes and Patient Survival.
    Contrib Nephrol 2017 12;189:1-8. Epub 2016 Dec 12.
    Patient morbidity and mortality rates are still very high in standard low-flux haemodialysis (lf-HD). On-line haemodiafiltration (OL-HDF) is considered the most efficient dialysis technique, as clearances of small solutes, like urea, may be even higher than in lf-HD and clearances of middle solutes, like β2-microglobulin, are much higher than in lf-HD. OL-HDF has been suggested to reduce mortality compared to HD, possibly due to more effective removal of larger uraemic retention solutes and/or better fluid removal. Read More

    Knowledge, attitudes and behaviors of the Italian population towards Neisseria meningitidis, Streptococcus pneumoniae and HPV diseases and vaccinations: A cross-sectional multicentre study.
    Public Health 2016 Dec 14;141:136-142. Epub 2016 Oct 14.
    Istituto di Sanità Pubblica - Sezione di Igiene, Università Cattolica del Sacro Cuore, Roma, Italy.
    Objectives: This study addressed knowledge of Streptococcus pneumoniae, Neisseria meningitidis and human papillomavirus (HPV), and attitudes and behaviours towards vaccines against them.

    Study Design: This is a cross-sectional, multicentre study.

    Methods: Data were collected through a questionnaire administered to 530 adults who accessed four Departments of Prevention of the Italian National Health Service in 2013. Read More

    Blood flow controls bone vascular function and osteogenesis.
    Nat Commun 2016 Dec 6;7:13601. Epub 2016 Dec 6.
    Faculty of Medicine, Department of Tissue Morphogenesis, Max-Planck-Institute for Molecular Biomedicine and University of Münster, D-48149 Münster, Germany.
    While blood vessels play important roles in bone homeostasis and repair, fundamental aspects of vascular function in the skeletal system remain poorly understood. Here we show that the long bone vasculature generates a peculiar flow pattern, which is important for proper angiogenesis. Intravital imaging reveals that vessel growth in murine long bone involves the extension and anastomotic fusion of endothelial buds. Read More

    A Clinicopathological and Dermoscopic Correlation of Seborrheic Keratosis.
    Indian J Dermatol 2016 Nov-Dec;61(6):622-627
    Department of Dermatology Venereology and Leprosy, Father Muller Medical College Hospital, Mangalore, Karnataka, India.
    Background: Seborrheic keratosis (SK) is the most common benign epidermal tumor of the skin. Even though SK has been well characterized clinically, dermoscopically, and histopathologically, data regarding clinical dermoscopic and histopathological correlation of different types of SK are inadequate.

    Aim: We carried out this study to establish any correlation between the clinical, dermoscopic, and histopathological appearance of SK and its variants. Read More

    Thoracostomy tube function not trajectory dictates reintervention.
    J Surg Res 2016 Dec 12;206(2):380-385. Epub 2016 Aug 12.
    Division of Trauma and Critical Care, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
    Background: Hemothorax and/or pneumothorax can be managed successfully managed with tube thoracostomy (TT) in the majority of cases. Improperly placed tubes are common with rates near 30%. This study aimed to determine whether TT trajectory affects the rate of secondary intervention. Read More

    Prevalence and characterization of neonatal skin disorders in the first 72h of life.
    J Pediatr (Rio J) 2016 Nov 19. Epub 2016 Nov 19.
    Universidade Federal do Rio Grande do Sul (UFRGS), Programa de Pós-graduação em Saúde da Criança e Adolescente, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Hospital de Clínicas de Porto Alegre (HCPA), Departamento de Dermatologia, Porto Alegre, RS, Brazil.
    Objective: To determine the prevalence of neonatal dermatological findings and analyze whether there is an association between these findings and neonatal and pregnancy characteristics and seasonality.

    Methods: Newborns from three maternity hospitals in a Brazilian capital city were randomly selected to undergo dermatological assessment by dermatologists.

    Results: 2938 neonates aged up to three days of life were randomly selected, of whom 309 were excluded due to Intensive Care Unit admission. Read More

    Milia-like calcinosis cutis in a girl with Down syndrome.
    An Bras Dermatol 2016 Sep-Oct;91(5):655-657
    Sakarya University Training and Research Hospital - Sakarya, Turkey.
    Milia-like idiopathic calcinosis cutis (MICC) is a very rare dermatological disorder characterized by multiple whitish to skin colored, milia-like papules, mostly found on the hands. MICC can disappear spontaneously by adulthood; therefore, its early recognition is crucial to avoiding unnecessary interventions. Herein, we present a case of MICC in a 6-year-old girl with Down syndrome. Read More

    Mean Blood Pressure Assessment during Post-Exercise: Result from Two Different Methods of Calculation.
    J Sports Sci Med 2016 Sep 5;15(3):424-433. Epub 2016 Aug 5.
    Department of Medical Sciences, Sports Physiology Lab., University of Cagliari , Italy.
    At rest the proportion between systolic and diastolic periods of the cardiac cycle is about 1/3 and 2/3 respectively. Therefore, mean blood pressure (MBP) is usually calculated with a standard formula (SF) as follows: MBP = diastolic blood pressure (DBP) + 1/3 [systolic blood pressure (SBP) - DBP]. However, during exercise this proportion is lost because of tachycardia, which shortens diastole more than systole. Read More

    [The use of drugs in chronic renal insufficiency: primum non nocere! (First do not harm!). The paradigmatic cases of azathioprine, metformin and denosumab].
    G Ital Nefrol 2016 Sep-Oct;33(5)
    Renal function reduction rises difficulties in dealing with many drugs. These problems are mainly due to the need of decreasing progressively the doses of the drugs that are cleared by the kidneys, in parallel with the progressive reduction in renal function. The degree of renal impairment should be better measured as the estimated glomerular filtration rate, avoiding to simply rely on plasma creatinine. Read More

    Clinical significance of computed tomography contrast extravasation in blunt trauma patients with a pelvic fracture.
    J Trauma Acute Care Surg 2017 Jan;82(1):138-140
    From the Division of Trauma/Critical Care, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
    Introduction: Blunt pelvic fractures can be associated with major pelvic bleeding. The significance of contrast extravasation (CE) on computed tomography (CT) is debated. We sought to update our experience with CE on CT scan for the years 2009-2014 to determine the accuracy of CE in predicting the need for angioembolization. Read More

    [Eruptive epidermoid cysts during topical imiquimod treatment].
    Ann Dermatol Venereol 2016 Oct 17. Epub 2016 Oct 17.
    Cabinet de dermatologie, 34, avenue d'Allemagne, 80000 Amiens, France.
    Background: Imiquimod is a local immune-response modifier that works by stimulating innate and acquired immunity. It is frequently used to treat superficial basal cell carcinoma, the most common form of skin cancer. Marked local inflammatory reaction is common during treatment. Read More

    Problems and complications of full-face carbon dioxide laser resurfacing for pathological lesions of the skin.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jan 23;123(1):e10-e15. Epub 2016 Aug 23.
    Division of Oral and Maxillofacial Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
    Objective: Facial resurfacing with a CO2 laser has been used for treatment of pathologic lesions and for cosmetic purposes. Postoperative complications and problems after laser resurfacing include infections, acneiform lesions, and pigment changes. This retrospective study describes the most common problems and complications in 105 patients and assesses postoperative pain in 38 patients. Read More

    Acne Fulminans: Case Series and Review of the Literature.
    Pediatr Dermatol 2016 Nov 4;33(6):e388-e392. Epub 2016 Oct 4.
    Department of Dermatology, Necker Enfants-Malades Hospital, Paris, France.
    Acne fulminans (AF) is a rare manifestation and the most severe form of the entire clinical spectrum of acne. The disease is destructive and is characterized by the sudden onset of painful and ulcerative pustules and systemic symptoms including high fever, hepatomegaly, polyarthralgia, leukocytosis, plaquetose, and increased inflammatory markers and transaminases. Osteolytic lesions in multiple skeletal sites could also be associated. Read More

    Localized axillary milia en plaque: a rare cutaneous case presentation of systemic amyloidosis.
    Clin Exp Dermatol 2016 Oct;41(7):764-7
    Department of Dermatology, Royal North Shore Hospital, St Leonards, NSW, Australia.
    Systemic AL amyloidosis is known to be associated with plasma cell dyscrasias, including multiple myeloma. The cutaneous manifestations of systemic AL amyloidosis are varied, but typically include waxy plaques or subcutaneous nodules. We report a woman who presented with bilateral eruptions of hyperpigmented plaques in her axillae, which were diagnosed as milia en plaque. Read More

    Multiple familial trichoepithelioma: confirmation via dermoscopy.
    Dermatol Pract Concept 2016 Jul 31;6(3):51-4. Epub 2016 Jul 31.
    Department of Dermatology, Complejo Asistencial Hospital Sótero del Río, Santiago, Chile.
    Trichoepitheliomas are uncommon benign adnexal neoplasms that originate from the hair follicles. Multiple familial trichoepithelioma constitute an autosomal dominant disease characterized by the appearance of multiple flesh-colored, symmetrical papules, tumors and/or nodules in the central face and occasionally on the scalp. Although clinical diagnosis is usually straightforward in light of the family history and naked-eye examination, dermoscopy may aid in its confirmation. Read More

    The Italian dementia with Lewy bodies study group (DLB-SINdem): toward a standardization of clinical procedures and multicenter cohort studies design.
    Neurol Sci 2017 Jan 13;38(1):83-91. Epub 2016 Sep 13.
    Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Piazza Spedali Civili 1, 25100, Brescia, Italy.
    Dementia with Lewy bodies (DLB) causes elevated outlays for the National Health Systems due to high institutionalization rate and patients' reduced quality of life and high mortality. Furthermore, DLB is often misdiagnosed as Alzheimer's disease. These data motivate harmonized multicenter longitudinal cohort studies to improve clinical management and therapy monitoring. Read More

    Penicillamine-associated cutis laxa and milia en plaque - case report and review of cutaneous changes associated with penicillamine.
    Dermatol Online J 2016 May 15;22(5). Epub 2016 May 15.
    University of California, San Diego School of Medicine.
    Penicillamine-induced skin changes are rare and include: hypersensitivity reactions, autoimmune reactions, and cutaneous elastoses. We report a case of a 73-year-old man with cystinuria taking penicillamine for over 50 years who presented with penicillamine-induced cutis laxa and milia en plaque. A brief review of penicillamine induced skin changes, specifically cutis laxa and milia en plaque, is presented. Read More

    Milia-like idiopathic calcinosis cutis in a child with Down syndrome.
    Dermatol Online J 2016 May 15;22(5). Epub 2016 May 15.
    Dermatology, Katihar Medical college , Katihar.
    Idiopathic calcinosis cutis refers to progressive deposition of crystals of calcium phosphate in the skin and other areas of the body, in the absence of any inciting factor. Idiopathic calcinosis cutis may sometimes take the form of small, milia-like lesions. Most commonly, such milia like lesions are seen in the setting of Down syndrome. Read More

    Predictors of healthy ageing: public health policy targets.
    BMC Health Serv Res 2016 Sep 5;16 Suppl 5:289. Epub 2016 Sep 5.
    Institute of Public Health, Università Cattolica del Sacro Cuore di Roma, Rome, Italy.
    Background: The public health policy agenda oriented towards healthy ageing becomes the highest priority for the European countries. The article discusses the healthy ageing concept and its possible determinants with an aim to identify behavioral patterns related to healthy ageing in selected European countries.

    Methods: The healthy ageing is assessed based on a composite indicator of self-assessed health, functional capabilities and life meaningfulness. Read More

    Workplace health promotion for older workers: a systematic literature review.
    BMC Health Serv Res 2016 Sep 5;16 Suppl 5:329. Epub 2016 Sep 5.
    Department of Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
    Background: Aging of the workforce is a growing problem. As workers age, their physical, physiological and psychosocial capabilities change. Keeping older workers healthy and productive is a key goal of European labor policy and health promotion is a key to achieve this result. Read More

    Cardio-metabolic responses during horse riding at three different speeds.
    Eur J Appl Physiol 2016 Oct 2;116(10):1985-92. Epub 2016 Aug 2.
    Department of Medical Sciences, Sports Physiology Laboratory, University of Cagliari (Italy), Via Porcell 4, 09124, Cagliari, Italy.
    Purpose: The purpose of the present investigation was to study the metabolic demand and cardiovascular response during a typical horse riding session.

    Methods: To this aim, 19 (9 male, 10 female) riders, regularly participating in competitions, were enrolled. They underwent a preliminary, incremental exercise test on a cycle-ergometer to assess their anaerobic threshold (AT) and VO2max. Read More

    A dual-stage approach to contaminated, high-risk ventral hernia repairs.
    J Surg Res 2016 Jul 6;204(1):200-4. Epub 2016 May 6.
    Division of Trauma and Critical Care, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
    Background: The Modified Hernia Grading System (MHGS) was developed to risk stratify complex ventral hernia repairs (VHRs). MHGS grade 3 patients have mesh infections, dirty or contaminated fields, and/or violation of the alimentary tract. Reported surgical site infection (SSI) rates are over 40% after single-stage VHR in contaminated fields. Read More

    Case Report: Whole exome sequencing reveals a novel frameshift deletion mutation p.G2254fs in COL7A1 associated with autosomal recessive dystrophic epidermolysis bullosa.
    F1000Res 2016 17;5:900. Epub 2016 May 17.
    GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics and Integrative Biology, Delhi, India; Academy of Scientific and Innovative Research, CSIR-IGIB South Campus, Delhi, India.
    Dystrophic epidermolysis bullosa simplex (DEB) is a phenotypically diverse inherited skin fragility disorder. It is majorly manifested by appearance of epidermal bullae upon friction caused either by physical or environmental trauma. The phenotypic manifestations also include appearance of milia, scarring all over the body and nail dystrophy. Read More

    Bioaugmentation-Assisted Phytostabilisation of Abandoned Mine Sites in South West Sardinia.
    Bull Environ Contam Toxicol 2016 Jul 6. Epub 2016 Jul 6.
    Institute of Environmental Geology and Geoengineering, National Research Council, Cagliari, Italy.
    Bioaugmentation-assisted phytoremediation implies the administration of selected plant growth promoting bacteria, which significantly improve plant growth and sequestration of heavy metals. In this work, 184 bacterial strains associated with roots of Pistacia lentiscus were isolated from plants spontaneously growing in the abandoned Sardinian mining areas (SW Sardinia, Italy) and phylogenetically characterised. Twenty-one bacterial isolates were assayed for properties relevant for plant growth promotion and metal tolerance. Read More

    Congenital Milia En Plaque.
    Pediatr Dermatol 2016 Jul 10;33(4):e258-9. Epub 2016 Jun 10.
    Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
    Milia en plaque is a rare, benign, localized, entity typically seen in adults after the third decade of life. Although there have been a few cases described in children, we describe the first case in a newborn. Read More

    [Molecular epidemiology of the lung cancer].
    Rev Mal Respir 2016 Oct 3;33(8):675-681. Epub 2016 Jun 3.
    Service de pneumologie, hôpital Larrey, CHU de Toulouse, université Paul-Sabatier, 31000 Toulouse, France. Electronic address:
    Lung cancers are common malignancies, which have a very poor prognosis. These are the leading cause of cancer deaths in France and worldwide. Behind this unfavourable prognosis hides many disparities according to age, sex, social level and exposure to risk factors. Read More

    TBK1 is associated with ALS and ALS-FTD in Sardinian patients.
    Neurobiol Aging 2016 Jul 9;43:180.e1-5. Epub 2016 Apr 9.
    "Rita Levi Montalcini" Department of Neuroscience, Amyotrophic Lateral Sclerosis Center, University of Turin, Turin, Italy; Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy; Neuroscience Institute of Torino (NIT), Turin, Italy; Institute of Cognitive Sciences and Technologies, Consiglio Nazionale delle Ricerche, Rome, Italy. Electronic address:
    Recently, mutations in the TANK-binding kinase 1 (TBK1) gene were identified as a cause for amyotrophic lateral sclerosis (ALS) with or without comorbid frontotemporal dementia. We have assessed the frequency and clinical characteristics of TBK1 mutations in a cohort of ALS patients of Sardinian ancestry. Whole-exome sequencing was performed on Hiseq2000 platform (Illumina). Read More

    Characteristics and Clinical Outcomes of Sarcomatoid Carcinoma of the Lung.
    Clin Lung Cancer 2016 Sep 17;17(5):391-397. Epub 2016 Mar 17.
    Pulmonary Medicine Unit, Hôpital Larrey, Centre Hospitalier Universitaire Toulouse, Université de Toulouse III, Toulouse, France. Electronic address:
    Background: Sarcomatoid carcinoma is a rare subtype of non-small-cell lung cancer, which has aggressive behavior. We present information on the clinicopathologic characteristics and clinical outcomes of these tumors.

    Patients And Methods: From January 2000 to December 2012, the clinicopathologic data from 93 patients treated at 2 French cancer centers were retrospectively analyzed. Read More

    Computed tomography based forensic gender determination by measuring the size and volume of the maxillary sinuses.
    J Forensic Dent Sci 2016 Jan-Apr;8(1):40-6
    Department of Oral Medicine and Radiology, Institute of Dental Studies and Technologies, Kadrabad, Modinagar, Uttar Pradesh, India.
    Purpose: Identification of human body or remains after death is a forensic procedure, which is difficult to perform and is mandatory by law and in compliance with social norms. Sexing the recovered human remains is an integral part of the identification process. Maxillary sinus can be used for gender determination as it remains intact even when the skull and other bones may be badly damaged in casualties where the body is incinerated. Read More

    Does angiotensin-converting enzyme-1 (ACE-1) gene polymorphism lead to chronic kidney disease among hypertensive patients?
    Ren Fail 2016 Jun 6;38(5):765-9. Epub 2016 Apr 6.
    b Max Super Specialty Hospital , Vaishali , Ghaziabad , Uttar Pradesh , India ;
    Background: Hypertension is one of the important contributing factors linked with both causation and development of kidney disease. It is a multifactorial, polygenic, and complex disorder due to interaction of several risk genes with environmental factors. The present study was aimed to explore genetic polymorphism in ACE-1 gene as a risk factor for CKD among hypertensive patients. Read More

    Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest.
    N Engl J Med 2016 May 4;374(18):1711-22. Epub 2016 Apr 4.
    From the Department of Medicine (P.J.K., T.R., G.N.) and Division of Cardiology (P.J.K.), University of Washington, the King County Emergency Medical Services, Public Health (P.J.K., T.R.), the Department of Biostatistics, University of Washington Clinical Trial Center (S.P.B., G.N., B.L.), and University of Washington-Harborview Center for Prehospital Emergency Care (G.N.), Seattle, and Clark County Emergency Medical Services, Vancouver (L.W.) - all in Washington; the Department of Emergency Medicine, Oregon Health and Science University, Portland (M.D.); Rescu, Li Ka Shing Knowledge Institute, St. Michael's Hospital (L.J.M., P.D.), and the Divisions of Emergency Medicine (L.J.M.) and Cardiology (P.D.), Department of Medicine, University of Toronto, Toronto, the Department of Emergency Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa (C.V., I.G.S.), and the Department of Emergency Medicine, Providence Health Care Research Institute, University of British Columbia Faculty of Medicine (J.C.), and Providence Health Care Research Institute and British Columbia Emergency Health Services (R.S.), Vancouver - all in Canada; University of Pittsburgh, Pittsburgh (C.W.C., A.M.B.); National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda (D.E., P.D.-N.), and Johns Hopkins University, Baltimore (M.L.W.) - both in Maryland; the Department of Emergency Medicine, Virginia Commonwealth University, Richmond (J.P.O.); the Departments of Emergency Medicine and Internal Medicine, University of Texas Southwestern Medical Center (A.H.I.), and Dallas Fire-Rescue Department (N.S.) - both in Dallas; the Departments of Emergency Medicine (T.P.A.) and Pediatrics (M.R.C.), Medical College of Wisconsin, Milwaukee; the Department of Emergency Medicine, University of California San Diego (J.V.D., G.M.V.), and San Diego Fire-Rescue Department (J.V.D.) - both in San Diego; and University of Alabama at Birmingham, Birmingham (P.C.G., R.G.).
    Background: Antiarrhythmic drugs are used commonly in out-of-hospital cardiac arrest for shock-refractory ventricular fibrillation or pulseless ventricular tachycardia, but without proven survival benefit.

    Methods: In this randomized, double-blind trial, we compared parenteral amiodarone, lidocaine, and saline placebo, along with standard care, in adults who had nontraumatic out-of-hospital cardiac arrest, shock-refractory ventricular fibrillation or pulseless ventricular tachycardia after at least one shock, and vascular access. Paramedics enrolled patients at 10 North American sites. Read More

    When Acne is Not Acne.
    Dermatol Clin 2016 Apr;34(2):225-8
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, 5 East 98 Street, 5th Floor, New York, NY 10029, USA.
    Acne vulgaris (AV) is considered a straightforward diagnosis made clinically without specific diagnostic testing. However, certain disorders may simulate AV, such as multiple small epidermal cysts or deep milia, multiple osteoma cutis, multiple small adnexal neoplasms, and follicular and/or infections characterized by multiple small papules and/or pustules such as gram-positive folliculitis, gram-negative folliculitis, Malassezia folliculitis, keratosis pilaris, and flat warts. This can lead to an erroneous diagnosis and improper management. Read More

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