68,455 results match your criteria Mild Cognitive Impairment

Vitamin D Receptor Gene Polymorphisms and Risk of Alzheimer Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.

Adv Nutr 2021 Jun 24. Epub 2021 Jun 24.

Department of Geratology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

The results from epidemiologic studies suggest that vitamin D receptor (VDR) gene polymorphisms are potentially associated with Alzheimer disease (AD) and mild cognitive impairment (MCI), but this association has yet to be confirmed. Here, we conducted a meta-analysis based on a larger sample size to clarify the contribution of VDR gene polymorphisms to MCI and AD susceptibility. The PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure databases were searched to obtain studies published before 30 October, 2020. Read More

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Mild Cognitive Impairment Classification using Combined Structural and Diffusion Imaging Biomarkers.

Phys Med Biol 2021 Jun 24. Epub 2021 Jun 24.

Electrical Engineering, Universidad Autónoma Metropolitana Iztapalapa, Iztapalapa, 09340, MEXICO.

Alzheimer's disease is a multifactorial neurodegenerative disorder preceded by a prodromal stage called mild cognitive impairment (MCI). Early diagnosis of MCI is crucial for delaying the progression and optimizing the treatment. In this study we propose a random forest (RF) classifier to distinguish between MCI and healthy control subjects (HC), identifying the most relevant features computed from structural T1-weighted and diffusion-weighted magnetic resonance images (sMRI and DWI), combined with neuro-psychological scores. Read More

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Cognitive dysfunction in central disorders of hypersomnolence: A systematic review.

Sleep Med Rev 2021 Jun 3;59:101510. Epub 2021 Jun 3.

IRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna, Italy; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy. Electronic address:

Central disorders of hypersomnolence (CDH) are characterized by excessive daytime sleepiness not related to comorbid sleep or medical disturbances. We systematically examined scientific literature on cognitive functions in patients suffering from CDH. Forty-eight studies proved eligible and were analyzed separately for Narcolepsy Type 1 (NT1), Narcolepsy Type 2 (NT2), Idiopathic hypersomnia (IH) and Kleine-Levin syndrome (KLS). Read More

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Does cognitive dysfunction correlate with dizziness severity in patients with vestibular migraine?

Am J Otolaryngol 2021 Jun 19;42(6):103124. Epub 2021 Jun 19.

Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA. Electronic address:

Objective: To characterize the relationship between dizziness severity and cognitive dysfunction in vestibular migraine (VM) patients.

Methods: Dizziness Handicap Inventory (DHI) and Cognitive Failures Questionnaire (CFQ) scores were compared pre- and post-treatment in a cohort of definite VM patients who underwent evaluation in a multidisciplinary clinic from 2016 to 2020.

Results: 44 patients were included. Read More

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Cognitive Performance in Older-Age Bipolar Disorder: investigating psychiatric characteristics, cardiovascular burden, and psychotropic medication.

Acta Psychiatr Scand 2021 Jun 24. Epub 2021 Jun 24.

Amsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health Research Institute, de Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Objective: This study aimed to explore a large range of candidate determinants of cognitive performance in older-age bipolar disorder (OABD).

Methods: A cross-sectional study was performed in 172 BD patients aged ≥50 years. Demographics, psychiatric characteristics, and psychotropic medication use were collected using self-report questionnaires and structured interviews. Read More

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[Vascular, molecular and cellular mechanisms of development of cognitive impairments after occlusion of carotid arteries].

S M Guliaev

Angiol Sosud Khir 2021 ;27(2):11-16

Laboratory of Experimental Pharmacology, Institute of General and Experimental Biology of the Siberian Branch of the Russian Academy of Sciences, Ulan-Ude, Russia.

Aim: The study was aimed at determining the role of vascular endothelial dysfunction in induction of molecular and cellular mechanisms of the development of cognitive impairments after occlusion of common carotid arteries.

Material And Methods: The experiments were carried out on Wistar rats. The animals were divided into 2 groups: group 1 - control, sham-operated animals; group 2 - rats with cerebral ischaemia-reperfusion. Read More

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January 2021

Semantic interference mechanisms on long-term visual memory and their eye-movement signatures in mild cognitive impairment.

Neuropsychology 2021 Jun 24. Epub 2021 Jun 24.

Human Cognitive Neuroscience, Psychology, University of Edinburgh.

Objective: Long-term visual memory representations, measured by recognition performance, degrade as a function of semantic interference, and their strength is related to eye-movement responses. Even though clinical research has examined interference mechanisms in pathological cognitive aging and explored the diagnostic potential of eye-movements in this context, little is known about their interaction in long-term visual memory.

Method: An eye-tracking study compared a Mild Cognitive Impaired group with healthy adults. Read More

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Extreme Glycemic Fluctuations Debilitate NRG1, ErbB Receptors and Olig1 Function: Association with Regeneration, Cognition and Mood Alterations During Diabetes.

Mol Neurobiol 2021 Jun 24. Epub 2021 Jun 24.

Institute of Science, Nirma University, Sarkhej-Gandhinagar Highway, Ahmedabad, 382 481, Gujarat, India.

Neuronal regeneration is crucial for maintaining intact neural interactions for perpetuation of cognitive and emotional functioning. The NRG1-ErbB receptor signaling is a key pathway for regeneration in adult brain and also associated with learning and mood stabilization by modulating synaptic transmission. Extreme glycemic stress is known to affect NRG1-ErbB-mediated regeneration in brain; yet, it remains unclear how the ErbB receptor subtypes are differentially affected due to such metabolic variations. Read More

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The relationship between cognitive functioning and psychopathology in patients with psychiatric disorders: a transdiagnostic network analysis.

Psychol Med 2021 Jun 24:1-10. Epub 2021 Jun 24.

Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.

Background: Patients with psychiatric disorders often experience cognitive dysfunction, but the precise relationship between cognitive deficits and psychopathology remains unclear. We investigated the relationships between domains of cognitive functioning and psychopathology in a transdiagnostic sample using a data-driven approach.

Methods: Cross-sectional network analyses were conducted to investigate the relationships between domains of psychopathology and cognitive functioning and detect clusters in the network. Read More

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Use of the Dementia Assessment Sheet for Community-based Integrated Care System 21 items among Chinese community-dwelling older adults.

Geriatr Gerontol Int 2021 Jun 24. Epub 2021 Jun 24.

Department of Social Medicine, School of Public Health, Zhejiang University, Hangzhou, China.

Aim: The objective of this study was to verify the reliability and validity of the Dementia Assessment Sheet for Community-based Integrated Care System 21 items (DASC-21) among Chinese community-dwelling older adults, and to explore the related factors for dementia screening.

Methods: The study adopted a cross-sectional design, and a total of 1152 participants aged ≥60 years were recruited from 26 locations in China. All data were collected using questionnaires through face-to-face interviews. Read More

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Associations Between Anticholinergic Medication Exposure and Adverse Health Outcomes in Older People with Frailty: A Systematic Review and Meta-analysis.

Drugs Real World Outcomes 2021 Jun 23. Epub 2021 Jun 23.

Academic Unit for Ageing and Stroke Research, University of Leeds, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.

Introduction: There are robust associations between use of anticholinergic medicines and adverse effects in older people. However, the nature of these associations for older people living with frailty is yet to be established.

Objectives: The aims were to identify and investigate associations between anticholinergics and adverse outcomes in older people living with frailty and to investigate whether exposure is associated with greater risks according to frailty status. Read More

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Changes in 24 h Rhythmicity of Spontaneous Locomotor Activity in the Triple Transgenic Mouse for Alzheimer's Disease (3xTg-AD) in a Jet Lag Protocol: Correlations with Retinal Sensitivity.

J Circadian Rhythms 2021 May 27;19. Epub 2021 May 27.

Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, México.

The progression of amyloid plaques and neurofibrillary tangles in different brain areas is associated with the effects of Alzheimer's disease (AD). In addition to cognitive impairment, circadian alterations in locomotor activity have also been detected, but they have not been characterized in a jet lag protocol. Therefore, the present study aimed to compare 3xTg-AD and non-transgenic mice in changes of 24 h cycles of spontaneous locomotor activity in a jet lag protocol, in an environment without a running wheel, at 3 different states of neuronal damage: early, intermediate and advanced (3, 8 and 13 months, respectively). Read More

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NANS-CDG: Delineation of the Genetic, Biochemical, and Clinical Spectrum.

Front Neurol 2021 7;12:668640. Epub 2021 Jun 7.

Department of Pediatric Metabolic Diseases, Emma Children's Hospital, Amsterdam University Medical Center, Amsterdam, Netherlands.

NANS-CDG is a recently described congenital disorder of glycosylation caused by biallelic genetic variants in , encoding an essential enzyme in sialic acid synthesis. Sialic acid at the end of glycoconjugates plays a key role in biological processes such as brain and skeletal development. Here, we present an observational cohort study to delineate the genetic, biochemical, and clinical phenotype and assess possible correlations. Read More

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Decline in Emotional Face Recognition Among Elderly People May Reflect Mild Cognitive Impairment.

Front Psychol 2021 7;12:664367. Epub 2021 Jun 7.

Department of Psychology, Faculty of Letters, Chuo University, Tokyo, Japan.

Background: As with cognitive function, the ability to recognize emotions changes with age. In the literature regarding the relationship between recognition of emotion and cognitive function during aging, the effects of predictors such as aging, emotional state, and cognitive domains on emotion recognition are unclear. This study was performed to clarify the cognitive functions underlying recognition of emotional facial expressions, and to evaluate the effects of depressive mood on recognition of emotion in elderly subjects, as well as to reproduce the effects of aging on the recognition of emotional facial expressions. Read More

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Dysfunction of the Glymphatic System as a Potential Mechanism of Perioperative Neurocognitive Disorders.

Front Aging Neurosci 2021 7;13:659457. Epub 2021 Jun 7.

Department of Anaesthesiology, China-Japan Union Hospital of Jilin University, Changchun, China.

Perioperative neurocognitive disorder (PND) frequently occurs in the elderly as a severe postoperative complication and is characterized by a decline in cognitive function that impairs memory, attention, and other cognitive domains. Currently, the exact pathogenic mechanism of PND is multifaceted and remains unclear. The glymphatic system is a newly discovered glial-dependent perivascular network that subserves a pseudo-lymphatic function in the brain. Read More

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Characterization of Brain Iron Deposition Pattern and Its Association With Genetic Risk Factor in Alzheimer's Disease Using Susceptibility-Weighted Imaging.

Front Hum Neurosci 2021 7;15:654381. Epub 2021 Jun 7.

Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

The presence of iron is an important factor for normal brain functions, whereas excessive deposition of iron may impair normal cognitive function in the brain and lead to Alzheimer's disease (AD). MRI has been widely applied to characterize brain structural and functional changes caused by AD. However, the effectiveness of using susceptibility-weighted imaging (SWI) for the analysis of brain iron deposition is still unclear, especially within the context of early AD diagnosis. Read More

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Aberrant maturation and connectivity of prefrontal cortex in schizophrenia-contribution of NMDA receptor development and hypofunction.

Mol Psychiatry 2021 Jun 23. Epub 2021 Jun 23.

Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, 19129, USA.

The neurobiology of schizophrenia involves multiple facets of pathophysiology, ranging from its genetic basis over changes in neurochemistry and neurophysiology, to the systemic level of neural circuits. Although the precise mechanisms associated with the neuropathophysiology remain elusive, one essential aspect is the aberrant maturation and connectivity of the prefrontal cortex that leads to complex symptoms in various stages of the disease. Here, we focus on how early developmental dysfunction, especially N-methyl-D-aspartate receptor (NMDAR) development and hypofunction, may lead to the dysfunction of both local circuitry within the prefrontal cortex and its long-range connectivity. Read More

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Olfactory neuropathology in Alzheimer's disease: a sign of ongoing neurodegeneration.

BMB Rep 2021 Jun 24. Epub 2021 Jun 24.

Department of Brain & Cognitive Sciences, Graduate School, Daegu Gyeungbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea; Convergence Research Advanced Centre for Olfaction, DGIST, Daegu 42988, Korea.

Olfactory neuropathology is a cause of olfactory loss in Alzheimer's disease (AD). Olfactory dysfunction is also associated with memory and cognitive dysfunction and is an incidental finding of AD dementia. Here we review neuropathological research on the olfactory system in AD, considering both structural and functional evidence. Read More

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Multifunctional Redox Modulators Protect Auditory, Visual and Cognitive Function.

Antioxid Redox Signal 2021 Jun 24. Epub 2021 Jun 24.

University of Nebraska Medical Center College of Pharmacy, 15519, Omaha, Nebraska, United States;

Significance: Oxidative stress contributes to vision, hearing and neurodegenerative disorders. Currently, no treatments prevent these disorders; therefore, there is an urgent need for redox modulator that can prevent these disorders. Recent Advances: Oxidative stress is associated with the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS), metal dyshomeostasis, and mitochondrial dysfunction. Read More

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Intrusion Errors and Progression of Cognitive Deficits in Older Adults with Mild Cognitive Impairment and PreMCI States.

Dement Geriatr Cogn Disord 2021 Jun 23:1-8. Epub 2021 Jun 23.

Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.

Introduction: Among persons with amnestic mild cognitive impairment (aMCI), intrusion errors on subscales that measure proactive semantic interference (PSI) may be among the earliest behavioral markers of elevated Alzheimer's disease brain pathology. While there has been considerable cross-sectional work in the area, it is presently unknown whether semantic intrusion errors are predictive of progression of cognitive impairment in aMCI or PreMCI (not cognitively normal but not meeting full criteria for MCI).

Methods: This study examined the extent to which the percentage of semantic intrusion errors (PIE) based on total responses on a novel cognitive stress test, the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L), could predict clinical/cognitive outcomes over an average 26-month period in older adults initially diagnosed with aMCI, PreMCI, and normal cognition. Read More

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[Functional pain syndromes - beyond nociception].

Rev Med Suisse 2021 Jun;17(744):1194-1199

Faculté de médecine, Université de Berne, 3010 Berne.

Functional pain disorders are frequent and represent a significant burden in primary care consultations. Scientific advances in neuroscience allow us to understand these syndromes from the perspective of perceptual, vegetative, affective and cognitive dysfunction. Simple tools can be useful in the history and clinical examination, looking specifically for positive signs in favor of a functional pain disorder. Read More

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MiR-132 down-regulates high glucose-induced β-dystroglycan degradation through Matrix Metalloproteinases-9 up-regulation in primary neurons.

J Cell Mol Med 2021 Jun 23. Epub 2021 Jun 23.

Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Cognitive dysfunction is one of the complications of diabetes. Unfortunately, there is no effective methods to block its progression currently. One of the pathophysiological mechanisms is synaptic protein damage and neuronal signal disruption because of glucose metabolism disorder. Read More

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Early manifestation of gait alterations in the Tg2576 mouse model of Alzheimer's disease.

Geroscience 2021 Jun 23. Epub 2021 Jun 23.

Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, 975 N. E. 10th Street - BRC 1303, Oklahoma City, OK, 73104, USA.

There is strong clinical evidence that multifaceted gait abnormalities may be manifested at early stages of Alzheimer's disease (AD), are related to cognitive decline, and can be used as an early biomarker to identify patients at risk of progressing to full-blown dementia. Despite their importance, gait abnormalities have not been investigated in mouse models of AD, which replicate important aspects of the human disease. The Tg2576 is frequently used in AD research to test therapeutic interventions targeting cellular mechanisms contributing to the genesis of AD. Read More

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Blood-brain barrier leakage at baseline and cognitive decline in cerebral small vessel disease: a 2-year follow-up study.

Geroscience 2021 Jun 23. Epub 2021 Jun 23.

Department of Neurology, Maastricht University Medical Center+, Oxfordlaan 10, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands.

Blood-brain barrier (BBB) dysfunction is one of the pathophysiological mechanisms in cerebral small vessel disease (SVD). Previously, it was shown that BBB leakage volume is larger in patients with SVD compared with controls. In this study, we investigated the link between BBB leakage and cognitive decline over 2 years in patients with cSVD. Read More

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Dexmedetomidine Ameliorates Postoperative Cognitive Dysfunction in Aged Mice.

Neurochem Res 2021 Jun 23. Epub 2021 Jun 23.

Department of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.

Neuroinflammation and oxidative stress coexist and interact in the progression of postoperative cognitive dysfunction (POCD) and other neurodegenerative disease. Mounting studies reveal that Dexmedetomidine (Dex) possesses anti-inflammatory and antioxidant properties. Nevertheless, whether Dex exerts neuroprotective effect on the cognitive sequelae of oxidative stress and inflammatory process remains unclear. Read More

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Role of comorbid depressive symptoms on the cognitive deficits in obsessive compulsive disorder.

Ind Psychiatry J 2020 Jul-Dec;29(2):302-309. Epub 2021 Mar 15.

Department of Psychiatry, Institute of Psychiatry-A Centre of Excellence, Kolkata, West Bengal, India.

Background: Obsessive compulsive disorder (OCD) is a chronic distressing condition that is marked with impairment in daily functioning including social, family, and occupational areas of life. Depression is the most common comorbidity among patients with OCD. The presence of co-occurring depressive symptoms adds to the burden of the OCD. Read More

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BACE1 controls synaptic function through modulating release of synaptic vesicles.

Mol Psychiatry 2021 Jun 22. Epub 2021 Jun 22.

Department of Neuroscience, UConn Health, Farmington, CT, USA.

BACE1 initiates production of β-amyloid peptides (Aβ), which is associated with cognitive dysfunction in Alzheimer's disease (AD) due to abnormal oligomerization and aggregation. While BACE1 inhibitors show strong reduction in Aβ deposition, they fail to improve cognitive function in patients, largely due to its role in synaptic function. We show that BACE1 is required for optimal release of synaptic vesicles. Read More

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Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility in male, but not female, mice.

Neuropsychopharmacology 2021 Jun 23. Epub 2021 Jun 23.

Department of Biomedical Sciences, Marquette University, Milwaukee, WI, USA.

Imbalance in prefrontal cortical (PFC) pyramidal neuron excitation:inhibition is thought to underlie symptomologies shared across stress-related disorders and neuropsychiatric disease, including dysregulation of emotion and cognitive function. G protein-gated inwardly rectifying K (GIRK/Kir3) channels mediate excitability of medial PFC pyramidal neurons, however, the functional role of these channels in mPFC-dependent regulation of affect, cognition, and cortical dynamics is unknown. We used a viral-cre approach in male and female mice harboring a "floxed" version of the kcnj3 (Girk1) gene, to disrupt GIRK1-containing channel expression in pyramidal neurons within the prelimbic cortex (PrL). Read More

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Characterizing the Clinical Features and Atrophy Patterns of -Related Frontotemporal Dementia With Disease Progression Modeling.

Neurology 2021 Jun 22. Epub 2021 Jun 22.

Department of Neurology, Ludwig-Maximilians Universität München, Munich, Germany.

Background And Objective: Mutations in the gene cause frontotemporal dementia (FTD). Most previous studies investigating the neuroanatomical signature of mutations have grouped all different mutations together and shown an association with focal atrophy of the temporal lobe. However, the variability in atrophy patterns between each particular mutation is less well characterised. Read More

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Lower White Matter Volume and Worse Executive Functioning Reflected in Higher Levels of Plasma GFAP among Older Adults with and Without Cognitive Impairment.

J Int Neuropsychol Soc 2021 Jun 22:1-12. Epub 2021 Jun 22.

Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.

Objective: There are minimal data directly comparing plasma neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) in aging and neurodegenerative disease research. We evaluated associations of plasma NfL and plasma GFAP with brain volume and cognition in two independent cohorts of older adults diagnosed as clinically normal (CN), mild cognitive impairment (MCI), or Alzheimer's dementia.

Methods: We studied 121 total participants (Cohort 1: n = 50, age 71. Read More

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