79,065 results match your criteria Mild Cognitive Impairment


Selective ablation of in astrocytes induces sex-specific effects on cognitive function, D-serine availability, and astrogliosis.

J Neurosci 2022 Jun 27. Epub 2022 Jun 27.

Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology;

Cognitive decline is a debilitating aspect of aging and neurodegenerative diseases such as Alzheimer's disease that is closely associated with mitochondrial dysfunction, increased reactive oxygen species (ROS), neuroinflammation and astrogliosis. This study investigated the effects of decreased mitochondrial antioxidant response specifically in astrocytes on cognitive performance and neuronal function in C57Bl/6J mice using a tamoxifen-inducible astrocyte-specific knockout of manganese superoxide dismutase (aSOD2-KO), a mitochondrial matrix antioxidant that detoxifies superoxide generated during mitochondrial respiration. We reduced astrocyte SOD2 levels in male and female mice at 11-12 months of age and tested in an automated home-cage (PhenoTyper) apparatus for diurnal patterns, spatial learning and memory function at 15 months of age. Read More

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A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer's disease.

Commun Med (Lond) 2022 20;2:70. Epub 2022 Jun 20.

Department of Surgery and Cancer, Imperial College London, London, UK.

Background: Alzheimer's disease, the most common cause of dementia, causes a progressive and irreversible deterioration of cognition that can sometimes be difficult to diagnose, leading to suboptimal patient care.

Methods: We developed a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted MRI scans, with or without cognitive scores. For each patient, a biomarker called "Alzheimer's Predictive Vector" (ApV) was derived using a two-stage least absolute shrinkage and selection operator (LASSO). Read More

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Shati/Nat8l Overexpression Improves Cognitive Decline by Upregulating Neuronal Trophic Factor in Alzheimer's Disease Model Mice.

Neurochem Res 2022 Jun 27. Epub 2022 Jun 27.

Department of Pharmaceutical Therapy and Neuropharmacology, School of Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Alzheimer's disease (AD) is a type of dementia characterized by the deposition of amyloid β, a causative protein of AD, in the brain. Shati/Nat8l, identified as a psychiatric disease related molecule, is a responsive enzyme of N-acetylaspartate (NAA) synthesis. In the hippocampi of AD patients and model mice, the NAA content and Shati/Nat8l expression were reported to be reduced. Read More

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[Cognitive training interventions for dementia and mild cognitive impairment in Parkinson's disease].

Z Gerontol Geriatr 2022 Jun 27. Epub 2022 Jun 27.

Geriatrisches Zentrum und Institut für Geriatrische Forschung, Universitätsklinikum Ulm, Zollernring 26, 89073, Ulm, Deutschland.

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[The influence of age and gender on the characteristics of cognitive impairment in patients with cardiovascular risks].

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(6):85-92

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Objective: Assessment of the features of cognitive impairment in patients with vascular risk factors, depending on age and gender.

Material And Methods: The observational cross-sectional study included data from 1.651 patients aged 45 to 84 years with vascular risk factors from various regions of the Russian Federation. Read More

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January 2022

[Cognitive functions in late-onset psychosis].

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(6):63-70

Mental Health Research Center, Moscow, Russia.

The review discusses cognitive functions in late-onset schizophrenia and very late-onset schizophrenia-like psychosis compared to cognition in normal aging, early-onset schizophrenia, and neurodegenerative diseases. The problem of the dynamics of the state of the cognitive functions in patients with late-onset schizophrenic psychoses is highlighted, and prospects for further research are discussed. Patients with late-onset schizophrenic psychosis are characterized by more pronounced cognitive deficits compared to normal aging, but less severe than cognitive changes observed in early-onset schizophrenia. Read More

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January 2022

Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer's Disease Brain.

ACS Chem Neurosci 2022 Jun 27. Epub 2022 Jun 27.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.

Synaptic dysfunction and loss occur in Alzheimer's disease (AD) brains, which results in cognitive deficits and brain neurodegeneration. Neuropeptides comprise the major group of synaptic neurotransmitters in the nervous system. This study evaluated neuropeptide signatures that are hypothesized to differ in human AD brain compared to age-matched controls, achieved by global neuropeptidomics analysis of human brain cortex synaptosomes. Read More

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Does reduced chewing ability efficiency influence cognitive function? Results of a 10-year national cohort study.

Medicine (Baltimore) 2022 Jun 24;101(25):e29270. Epub 2022 Jun 24.

Department of Preventive and Social Dentistry, Seoul National University School of Dentistry, Seoul, South Korea.

Abstract: A growing body of literature suggests that oral health can influence cognitive function during aging. However, it is currently unclear whether reduced masticatory efficiency influences cognitive impairment in longitudinal studies.This study sought to investigate the effects of reduced chewing ability on the incidence of cognitive impairment using national representative data from 10 years of follow-up in Korea. Read More

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Risk of developing cognitive impairment on patients with chronic obstructive pulmonary disease: A systematic review.

Medicine (Baltimore) 2022 Jun 24;101(25):e29235. Epub 2022 Jun 24.

Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Background: The increasing number of chronic obstructive pulmonary disease (COPD) incidence has led to a great negative impact on older people's lives. This chronic disease was a critical and independent risk factor for cognitive function impairment in the elderly with mild cognitive impairment as a frequent feature. This systematic review aimed to examine the risk of developing cognitive impairment in COPD. Read More

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EEG Resting-State Functional Networks in Amnestic Mild Cognitive Impairment.

Clin EEG Neurosci 2022 Jun 26:15500594221110036. Epub 2022 Jun 26.

Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), 18998University of Palermo, Palermo, Italy.

. Alzheimer's cognitive-behavioral syndrome is the result of impaired connectivity between nerve cells, due to misfolded proteins, which accumulate and disrupt specific brain networks. Electroencephalography, because of its excellent temporal resolution, is an optimal approach for assessing the communication between functionally related brain regions. Read More

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ALZT-OP1: An experimental combination regimen for the treatment of Alzheimer's Disease.

Expert Opin Investig Drugs 2022 Jun 25. Epub 2022 Jun 25.

Unit of Research Methodology and Data Sciences for Population Health, National Institute of Gastroenterology and Research Hospital IRCCS "S. De Bellis" Castellana Grotte, Bari, Italy.

Introduction: For Alzheimer's disease (AD) treatment, US FDA granted accelerated approval for aducanumab due to its amyloid-β (Aβ)-lowering effects, notwithstanding the reported poor correlation between amyloid plaque reduction and clinical change for this drug. The diversification of drug targets appears to be the future of the AD field and from this perspective, drugs modulating microglia dysfunction and combination treatment regimens offer some promise.

Areas Covered: The aim of the present article was to provide a comprehensive review of ALZT-OP1 (cromolyn sodium plus ibuprofen), an experimental combination treatment regimen for AD, discussing their mechanisms of action targeting Aβ and neuroinflammation, examining the role of microglia in AD and offering our own insights on the role of present and alternative approaches directed toward neuroinflammation. Read More

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Does cognitive impairment precede self-reported poor hearing? Results from the English longitudinal study of ageing.

Int J Audiol 2022 Jun 25:1-8. Epub 2022 Jun 25.

Postgraduate Program of Collective Health, Federal University of Santa Catarina, Florianópolis, Brazil.

Objective: To investigate whether cognitive impairment precedes self-reported poor hearing in adults aged 50 and older over a 14-year period.

Design: Biennial longitudinal study.

Study Sample: The data came from the English Longitudinal Study of Ageing carried out in England between 2002 and 2016, with 11,391 individuals aged 50 years and older. Read More

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IL-17A deletion reduces sevoflurane-induced neurocognitive impairment in neonatal mice by inhibiting NF-κB signaling pathway.

Bioengineered 2022 Jun;13(6):14562-14577

Department of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

We investigated the role of IL-17A in sevoflurane-inducedneurocognitive impairment in neonatal mice. Seventy-two wild-type (WT) and 42 IL-17A knockout (KO) neonatal mice were randomly divided into WT ( = 36), IL-17A ( = 6), sevoflurane (Sev, = 36), and IL-17A + sevoflurane (IL-17A + Sev, = 36) groups. The latter two groups were given 3% sevoflurane for 2 h per day on postnatal days (P) 6-8. Read More

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High Fall Risk Associated With Memory Deficit and Brain Lobes Atrophy Among Elderly With Amnestic Mild Cognitive Impairment and Mild Alzheimer's Disease.

Front Neurosci 2022 8;16:896437. Epub 2022 Jun 8.

Department of Neurology, First People's Hospital of Foshan, Foshan, China.

Objectives: This study aimed to primarily examine the association between memory deficit and increased fall risk, second, explore the underlying neuroanatomical linkage of this association in the elderly with aMCI and mild AD.

Methods: In this cross-sectional study, a total of 103 older adults were included (55 cognitively normal, CN; 48 cognitive impairment, CI, elderly with aMCI, and mild AD). Memory was assessed by the Auditory Verbal Learning Test (AVLT). Read More

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Combination of Acupoints for Alzheimer's Disease: An Association Rule Analysis.

Front Neurosci 2022 8;16:872392. Epub 2022 Jun 8.

Division of Neurosurgery, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.

Background: Alzheimer's disease (AD) is an ongoing neurological degeneration characterized by amnesia and a decline in cognitive abilities. Hippocampal neurogenesis is the leading cause of AD. Mild cognitive impairment (MCI), a prodromal state of AD, is mainly due to the degradation of neuropsychiatric manifestations. Read More

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Mesenchymal Stem Cell Therapy: A Potential Treatment Targeting Pathological Manifestations of Traumatic Brain Injury.

Oxid Med Cell Longev 2022 15;2022:4645021. Epub 2022 Jun 15.

Center of Implant Dentistry, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, China.

Traumatic brain injury (TBI) makes up a large proportion of acute brain injuries and is a major cause of disability globally. Its complicated etiology and pathogenesis mainly include primary injury and secondary injury over time, which can cause cognitive deficits, physical disabilities, mood changes, and impaired verbal communication. Recently, mesenchymal stromal cell- (MSC-) based therapy has shown significant therapeutic potential to target TBI-induced pathological processes, such as oxidative stress, neuroinflammation, apoptosis, and mitochondrial dysfunction. Read More

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Potential Benefits of Music Therapy on Stroke Rehabilitation.

Oxid Med Cell Longev 2022 15;2022:9386095. Epub 2022 Jun 15.

Department of Science and Education, Hangzhou Women's Hospital, Hangzhou Maternity and Child Health Care Hospital, Hangzhou, China.

Stroke is associated with a high rate of disability and mortality, and survivors are usually accompanied with dysphagia, aphasia, motor dysfunction, cognitive impairment, depression, and other complications. In the past decades, many studies have been conducted to reveal the pathogenesis and pathological mechanisms of stroke. Furthermore, treatment methods have been developed that contribute to the elevated survival rate of stroke patients. Read More

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Psychological Resilience Among Older Japanese Adults With Mild Cognitive Impairment During the COVID-19 Pandemic.

Front Psychiatry 2022 10;13:898990. Epub 2022 Jun 10.

Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Obu, Japan.

Psychological resilience refers to the ability to cope with adversities, and deficits in resilience might lead to mental illness. The COVID-19 pandemic has had impact on psychological resilience for older adults, but there are as yet no data on its impacts on the mental health of older adults who were living with mild cognitive impairment (MCI). Therefore, the aim of this study was to investigate the impact of the COVID-19 pandemic on psychological resilience in older adults with MCI and to explore associated physical and psychosocial factors. Read More

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Short Chain Fatty Acids Protect the Cognitive Function of Sepsis Associated Encephalopathy Mice via GPR43.

Front Neurol 2022 10;13:909436. Epub 2022 Jun 10.

Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Objective: This study aims to analyze the changes of fecal short chain fatty acids (SCFAs) content and gut microbiota composition in sepsis associated encephalopathy (SAE) mice, further evaluating the effect of SCFAs on cognitive function and the underlying mechanism in SAE mice.

Methods: A total of 55 male adult C57BL/6 mice (2-3 months of age, 20-25 g) were divided into four groups randomly: sham group ( = 10), cecal ligation and puncture group (CLP group, = 15), CLP+SCFAs group ( = 15), and CLP+SCFAs+GLPG0974 group ( = 15). Seven days after surgery, fecal samples were collected for microbiota composition and SCFA analysis from 6 mice in each group randomly. Read More

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Rates of Cognitive Decline in 100 Patients With Alzheimer Disease.

Ochsner J 2022 ;22(2):129-133

Department of Infectious Diseases, Ochsner Clinic Foundation, New Orleans, LA.

In the state of Louisiana, the prevalence of Alzheimer disease (AD) is projected to increase 26.4% by 2025 because of the rapidly increasing geriatric population. While significant research is available on risk factors for developing AD, less data are available regarding AD progression and the rate of change among patients with the disease. Read More

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January 2022

Age-Dependent Association Between Cognitive Reserve Proxy and Longitudinal White Matter Microstructure in Older Adults.

Front Psychol 2022 10;13:859826. Epub 2022 Jun 10.

Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.

Objective: This study examined the association of lifetime experiences, measured by a cognitive reserve (CR) composite score composed of years of education, literacy, and vocabulary measures, to level and rate of change in white matter microstructure, as assessed by diffusion tensor imaging (DTI) measures. We also examined whether the relationship between the proxy CR composite score and white matter microstructure was modified by participant age, -ε4 genetic status, and level of vascular risk.

Methods: A sample of 192 non-demented ( = 166 cognitively normal, = 26 mild cognitive impairment) older adults [mean age = 70. Read More

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Plasma levels of BDNF and EGF are reduced in acute stroke patients.

Heliyon 2022 Jun 10;8(6):e09661. Epub 2022 Jun 10.

Department of Behavioral Sciences, Faculty of Health Sciences, OsloMet-Oslo Metropolitan University, Oslo, Norway.

Stroke affects almost 14 million people worldwide each year. It is the second leading cause of death and a major cause of acquired disability. The degree of initial impairment in cognitive and motor functions greatly affects the recovery, but idiosyncratic factors also contribute. Read More

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Electrochemical Determination of Manganese in Whole Blood with Indium Tin Oxide Electrode.

J Electrochem Soc 2022 May 11;169(5). Epub 2022 May 11.

Department of Biomedical Engineering, University of Illinois Chicago, Illinois 60607, USA.

In this work, we demonstrate accurate and precise measurement of manganese (Mn) concentration in human whole blood with indium tin oxide (ITO) electrode using square wave stripping voltammetry. While an essential trace metal for human health, elevated levels of Mn due to environmental or occupational exposure have been associated with severe neuromotor dysfunction characterized by parkinsonism and cognitive dysfunction making the monitoring of Mn in whole blood necessary. Pediatric populations are particularly susceptible to Mn given their developing brain and potential long-term impacts on neurodevelopment. Read More

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Methodology and preliminary data on feasibility of a neurofeedback protocol to improve visual attention to letters in mild Alzheimer's disease.

Contemp Clin Trials Commun 2022 Aug 13;28:100950. Epub 2022 Jun 13.

Institute on Development & Disability, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.

Background: Brain-computer interface (BCI) systems are controlled by users through neurophysiological input for a variety of applications, including communication, environmental control, and motor rehabilitation. Although individuals with severe speech and physical impairment are the primary users of this technology, BCIs have emerged as a potential tool for broader populations, including delivering cognitive training/interventions with neurofeedback (NFB).

Methods: This paper describes the development and preliminary testing of a protocol for use of a BCI system with NFB as an intervention for people with mild Alzheimer's disease (AD). Read More

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Alteration of Visuospatial System as an Early Marker of Cognitive Decline: A Double-Center Neuroimaging Study.

Front Aging Neurosci 2022 10;14:854368. Epub 2022 Jun 10.

Neurocognitive Research Center, National Institute of Mental Health, Neurology and Neurosurgery, Budapest, Hungary.

Amnestic-type mild cognitive impairment (a-MCI) represents the prodromal phase of Alzheimer's disease associated with a high conversion rate to dementia and serves as a potential golden period for interventions. In our study, we analyzed the role of visuospatial (VS) functions and networks in the recognition of a-MCI. We examined 78 participants (32 patients and 46 controls) in a double-center arrangement using neuropsychology, structural, and resting-state functional MRI. Read More

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Effect of Different Vitamin D Levels on Cognitive Function in Aged Mice After Sevoflurane Anesthesia.

Front Aging Neurosci 2022 10;14:940106. Epub 2022 Jun 10.

Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China.

Although the biological relationship between vitamin D (VD) deficiency and cognitive function has been recognized by many scholars, the theoretical mechanisms involved are still not well-understood. In this study, we demonstrated the role of VD in alleviating the cognitive dysfunction in aged mice caused by sevoflurane anesthesia. Forty female C57BL/6 mice aged 12 months were selected for the experiment. Read More

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Based on Network Pharmacology and Molecular Dynamics Simulations, Baicalein, an Active Ingredient of Yiqi Qingre Ziyin Method, Potentially Protects Patients With Atrophic Rhinitis From Cognitive Impairment.

Front Aging Neurosci 2022 10;14:880794. Epub 2022 Jun 10.

Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Cognition may be improved by the active ingredients of the Yiqi Qingre Ziyin method in patients with atrophic rhinitis (AR). This study aimed to identify potential targets of the Yiqi Qingre Ziyin method for the treatment of patients with cognitive impairment. Nasal mucosal tissue samples from patients with AR were subjected to proteomic assays, and differentially expressed proteins were obtained. Read More

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A Neuropsychological Rehabilitation Framework to Address Cognitive and Neurobehavioral Impairments After Strokes to the Anterior Communicating Artery.

Front Hum Neurosci 2022 10;16:808011. Epub 2022 Jun 10.

Clinical Neuropsychology Unit, Centre for Human Neuroscience and Neuropsychology, Faculty of Psychology, Diego Portales University, Santiago, Chile.

Patients with strokes to the Anterior Communicating Artery (ACoA) pose an important challenge to rehabilitation teams due to a particular mix of cognitive and behavioral impairments (anosognosia, anterograde amnesia, prospective memory problems, and executive dysfunction). These deficits often compromise engagement with rehabilitation, learning and generalization. The goal of this article is to describe the long-term presentation of a patient with an ACoA stroke (Mrs. Read More

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Pathological changes of brain oscillations following ischemic stroke.

J Cereb Blood Flow Metab 2022 Jun 25:271678X221105677. Epub 2022 Jun 25.

Department of Neurological Surgery, UCSF, San Francisco, CA, USA.

Brain oscillations recorded in the extracellular space are among the most important aspects of neurophysiology data reflecting the activity and function of neurons in a population or a network. The signal strength and patterns of brain oscillations can be powerful biomarkers used for disease detection and prediction of the recovery of function. Electrophysiological signals can also serve as an index for many cutting-edge technologies aiming to interface between the nervous system and neuroprosthetic devices and to monitor the efficacy of boosting neural activity. Read More

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Natural Pattern of Cognitive Aging.

J Alzheimers Dis 2022 Jun 20. Epub 2022 Jun 20.

Translational Neuroscience and Aging Program, Centre for Translational Medicine, St. Anne's University Hospital, Brno, Czech Republic.

Background: Considering the world's rapidly increasing life expectancy, with people working and maintaining active lifestyles longer than ever before, addressing the effects of aging on cognition is of utmost importance. A greater understanding of cognitive aging may also be critical in distinguishing natural cognitive aging from pre-clinical stages of Alzheimer's disease and related cognitive disorders.

Objective: To systematically examine the association between aging and cognitive performance in a cognitively and otherwise healthy probability population-based sample using a computer-based method. Read More

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