315,922 results match your criteria Mild Cognitive Impairment


Therapeutic Hypothermia in Brazil: A MultiProfessional National Survey.

Am J Perinatol 2018 Dec 15. Epub 2018 Dec 15.

Department of Pediatrics, Neonatal Division, McGill University Health Center, Montreal, Quebec, Canada.

Objective:  To determine the rate of therapeutic hypothermia (TH) use, current practices, and long-term follow-up.

Study Design:  Prospective cross-sectional national survey with 19 questions related to the assessment of hypoxic-ischemic encephalopathy (HIE) and TH practices. An online questionnaire was made available to health care professionals working in neonatal care in Brazil. Read More

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December 2018
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Double mild stimulation and egg collection in the same cycle for management of poor ovarian responders.

J Gynecol Obstet Hum Reprod 2018 Dec 12. Epub 2018 Dec 12.

Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Electronic address:

Purpose: To evaluate the effect of double stimulations during the follicular and luteal phases in women with poor ovarian response (POR) in in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles.

Basic Procedures: This prospective clinical study was performed in Royan Institute from October 2014 to January 2016. 121 patients were diagnosed as POR on the basis of Bologna criteria were included. Read More

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December 2018

Comparison of fatigue, pain and depression in patients with advanced kidney disease and cancer - symptom burden and clusters.

J Pain Symptom Manage 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA.

Context: While symptom clusters have been studied in the context of cancer, few data exist in chronic and end stage kidney disease (CKD/ESKD) patients.

Objectives: To (1) characterize and compare symptom cluster phenotypes in patients with advanced CKD, ESKD and cancer, and (2) explore predictors of symptom clusters.

Methods: We conducted secondary data analysis of three prospective studies in which pain, depression, and fatigue were assessed in patients with stage 4-5 CKD, ESKD and gastrointestinal (GI) cancer. Read More

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December 2018

Differential executive functioning in young adulthood as a function of experienced child abuse.

Int J Psychophysiol 2018 Dec 12. Epub 2018 Dec 12.

University of North Dakota, United States of America.

Introduction: Previous research has shown cognitive dysfunction in adults with a history of child abuse. The purpose of the present study was to measure differences that exist in executive functioning skills between individuals who have been abused as children versus those without the history of childhood abuse.

Methods: The present study recruited 43 students from the University of North Dakota (33 women) between ages 18 and 23 years of age. Read More

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December 2018

Management of invasive squamous cell carcinomas of the conjunctiva Treatment of invasive conjunctival carcinoma.

Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Pasteur 2 Teaching Hospital, Nice, France.

Purpose: Ocular Surface Squamous Neoplasia includes a spectrum of diseases from dysplasia to invasive squamous cell carcinoma of the conjunctiva. Whether the degree of invasion influences outcomes is debated. We evaluated the outcomes and management of conjunctival carcinomas defined as ≤0. Read More

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December 2018

Receptor tyrosine kinase MET as potential target of multi-kinase inhibitor and radiosensitizer sorafenib in HNSCC.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Laboratory of Radiobiology and Experimental Radiation Oncology, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg, Hamburg-Eppendorf, Germany.

Background: The multi-kinase inhibitor sorafenib displays antitumoral effects in head and neck squamous cell carcinoma (HNSCC); however, the targeted kinases are unknown. Here we aimed to identify those kinases to determine the mechanism of sorafenib-mediated effects and establish candidate biomarkers for patient stratification.

Methods: The effects of sorafenib and MET inhibitors crizotinib and SU11274 were analyzed using a slide-based antibody array, Western blotting, proliferation, and survival assays. Read More

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December 2018

Remission of hyperglycemia in spontaneously diabetic NOD mice upon transplant of microencapsulated human umbilical cord Wharton jelly-derived mesenchymal stem cells (hUCMS).

Xenotransplantation 2018 Dec 15:e12476. Epub 2018 Dec 15.

Section of Cardiovascular, Endocrine and Metabolic Clinical Physiology, and Laboratory for Endocrine Cell Transplants and Biohybrid Organs, Department of Medicine, University of Perugia, Perugia, Italy.

Background: Our previous in vitro demonstration of the immunoregulatory effects of microencapsulated hUCMS on human peripheral blood mononuclear cells (PBMCs) extracted from patients with recent onset, type 1 diabetes mellitus (DM), prompted us to test our product for xenograft (TX) in non obese diabetic (NOD) mice with spontaneous DM.

Methods: We transplanted microencapsulated hUCMS into the peritoneal cavity of NOD mice with either severe or mild DM. Blood glucose (BG) levels were monitored following TX, in either basal or upon glucose stimulation. Read More

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December 2018

Vagus nerve stimulation reduces ventricular arrhythmias and increases ventricular electrical stability.

Pacing Clin Electrophysiol 2018 Dec 15. Epub 2018 Dec 15.

Xinjiang Key Laboratory of Medical Animal Model Research, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Background: Transcutaneous stimulation of the auricular branch of the vagus nerve (AB-VNS) is a potentially non-invasive, inexpensive and safe approach for vagus nerve stimulation that suppresses the induction and duration of atrial fibrillation and reduces sympathetic nerve outflow in healthyhumans. Researchers have not determined whether AB-VNS affects ventricular arrhythmias.

Objective: To evaluate the antiarrhythmic effects of noninvasive AB-VNS on ventricular arrhythmias induced by myocardial infarction (MI). Read More

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December 2018

Selective mono-allylation of 1,3-diketones and their use in the synthesis of 3-allyl chromones and benzannulated 6,5-bicyclic ketals.

Chem Asian J 2018 Dec 14. Epub 2018 Dec 14.

University of Otago, Department of Chemistry, P.O. Box 56, 9054, Dunedin, NEW ZEALAND.

The selective mono-allylation of 1,3-diketone containing compounds is described. The reaction proceeds under mild reaction conditions and in moderate to high yield (66-99%). Using this procedure to access the key mono-allylated intermediate, the hitherto difficult to access, 3-allyl chromones were synthesized in excellent yield (87-98%). Read More

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December 2018

MIP-1α induces inflammatory responses by upregulating chemokine receptor 1/chemokine receptor 5 and activating c-Jun N-terminal kinase and mitogen-activated protein kinase signaling pathways in acute pancreatitis.

J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.

Intensive Care Unit, Shengjing Hospital, Medical University, Shenyang, Liaoning, China.

Objective: We aimed to investigate the association of macrophage inflammatory protein (MIP)-1α (CCL3) expression with the severity of acute pancreatitis (AP).

Methods: The patients with AP were selected and divided into mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP) groups according to the severity of AP. The pancreatic acinar cell line Ar42 j was treated with cerulein to induce in vitro cell AP model. Read More

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December 2018

Catecholamine Response to Exercise in Patients with Non-Obstructive Hypertrophic Cardiomyopathy.

J Physiol 2018 Dec 15. Epub 2018 Dec 15.

Division of Cardiology, Massachusetts General Hospital, 55 Fruit Street, Yawkey Suite 5B, Boston, MA, USA.

Key Points Summary: Intense physical activity, a potent stimulus for sympathetic nervous system activation, is thought to increase the risk of malignant ventricular arrhythmias among patients with hypertrophic cardiomyopathy (HCM). As a result, the majority of patients with HCM deliberately reduce their habitual physical activity after diagnosis and this lifestyle change puts them at risk for sequelae of a sedentary lifestyle; weight gain, hypertension, hyperlipidemia, insulin resistance, coronary artery disease and increased morbidity and mortality. We show that plasma catecholamine levels remain stably low at exercise intensities below the ventilatory threshold, a parameter that can be defined during cardiopulmonary exercise testing, but rise rapidly at higher intensities of exercise. Read More

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December 2018
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What Is Behind Cerebellar Vertigo and Dizziness?

Cerebellum 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurology, Ludwig-Maximilians University, Marchioninistrasse 15, 81377, Munich, Germany.

The differential diagnosis of vertigo or dizziness as a result of cerebellar disorders can be difficult as many patients with a cerebellar pathology do not present with the full spectrum of cerebellar signs. The main goal of this study was to describe the typical clinical features of these patients with vertigo or dizziness of a cerebellar origin. We reviewed the medical records of 5400 patients with vertigo and dizziness from our tertiary outpatient clinic for vertigo and balance disorders. Read More

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December 2018

A population-based study of cystic white matter injury on ultrasound in very preterm infants born over two decades in Nova Scotia, Canada.

J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology, Dalhousie University and the IWK Health Centre, Halifax, NS, Canada.

Objective: To identify the temporal trends, risk factors and outcomes of cystic white matter injury (WMI) detected by ultrasound in a population-based cohort of very preterm infants (VPI) with a minimal risk of selection bias.

Study Design: All live-born VPIs between 22 and < 31 weeks gestational age born in Nova Scotia, Canada from 1993 to 2013.

Results: Cystic WMI was identified in 87 (7%) out of 1184 eligible infants. Read More

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December 2018

Gender-specific discrepancy in subjective global assessment for mortality in hemodialysis patients.

Sci Rep 2018 Dec 14;8(1):17846. Epub 2018 Dec 14.

Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.

Although subjective global assessment (SGA) is a widely used representative tool for nutritional investigations even among dialysis patients, no studies have examined gender-specific differences in the ability of SGA to predict mortality in hemodialysis (HD) patients. A total of 2,798 dialysis patients were enrolled from clinical research center for end-stage renal disease (CRC for ESRD) between 2009 and 2015. The cohort was divided into two groups based on nutritional status as evaluated by SGA: 'good nutrition' and 'mild to severe malnutrition'. Read More

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December 2018
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Nanopore-based detection and characterization of yam viruses.

Sci Rep 2018 Dec 14;8(1):17879. Epub 2018 Dec 14.

CIRAD, BGPI, Montpellier, France.

We here assessed the capability of the MinION sequencing approach to detect and characterize viruses infecting a water yam plant. This sequencing platform consistently revealed the presence of several plant virus species, including Dioscorea bacilliform virus, Yam mild mosaic virus and Yam chlorotic necrosis virus. A potentially novel ampelovirus was also detected by a complimentary Illumina sequencing approach. Read More

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December 2018

Impaired Sensitivity to Thyroid Hormones Is Associated With Diabetes and Metabolic Syndrome.

Diabetes Care 2018 Dec 14. Epub 2018 Dec 14.

Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Universidad de Zaragoza, Zaragoza, Spain.

Objective: Diabetes prevalence and incidence increase among individuals with hypothyroidism but also among those with hyperthyroxinemia, which seems contradictory. Both high free thyroxine (fT4) and high thyroid-stimulating hormone (TSH) are present in the resistance to thyroid hormone syndrome. A mild acquired resistance to thyroid hormone might occur in the general population and be associated with diabetes. Read More

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December 2018
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Cortical thickness atrophy in the transentorhinal cortex in mild cognitive impairment.

Neuroimage Clin 2018 Dec 5. Epub 2018 Dec 5.

Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD 21218, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA.

This study examines the atrophy rates of subjects with mild cognitive impairment (MCI) compared to controls in four regions within the medial temporal lobe: the transentorhinal cortex (TEC), entorhinal cortex (ERC), hippocampus, and amygdala. These regions were manually segmented and then corrected for undesirable longitudinal variability via Large Deformation Diffeomorphic Metric Mapping (LDDMM) based longitudinal diffeomorphometry. Diffeomorphometry techniques were used to compare thickness measurements in the TEC with the ERC. Read More

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December 2018

The influence of mental health on Patient-Reported Outcomes Measurement Information System (PROMIS) and traditional outcome instruments in patients with symptomatic glenohumeral arthritis.

J Shoulder Elbow Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Orthopaedic Surgery, Washington University in St Louis, St Louis, MO, USA.

Background: The Patient-Reported Outcomes Measurement Information System (PROMIS) assessment includes computerized adaptive tests (CATs) that assess function, pain, depression, and anxiety. The influence of mental health on patients' self-reported pain and function has not been explored using PROMIS in patients with symptomatic glenohumeral osteoarthritis.

Methods: This cross-sectional study included 284 shoulders in 276 patients presenting with isolated glenohumeral osteoarthritis. Read More

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December 2018

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Lancet Respir Med 2018 Dec 11. Epub 2018 Dec 11.

Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK. Electronic address:

Background: Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types of asthma contribute to moderate-to-severe asthma, and provide novel mechanistic insights using expression analyses in patients with asthma.

Methods: In this genome-wide association study, we used a two-stage case-control design. Read More

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December 2018

Early onset children's interstitial lung diseases: Discrete entities or manifestations of pulmonary dysmaturity?

Paediatr Respir Rev 2018 Oct 9. Epub 2018 Oct 9.

Department of Histopathology, Royal Brompton & Harefield NHS Foundation Trust and National Heart and Lung Institute, Imperial College, London, UK.

Interstitial lung diseases in children (chILD) are rare and diverse. The current classifications include a group of early onset chILD specific to infancy, namely neuro-endocrine cell hyperplasia of infancy (NEHI), pulmonary interstitial glycogenosis (PIG) and the alveolar capillary-congenital acinar dysplasia (ACD-CAD) spectrum, as well as alveolar growth disorders. NEHI and PIG cells are seen in the normal developing foetal lung. Read More

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October 2018

Diagnostic sensitivity of electrophysiology and ultrasonography in ulnar neuropathies of different severity.

Clin Neurophysiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurology and Clinical Neurophysiology, Auckland District Health Board, Auckland Hospital, Auckland, New Zealand.

Objective: To assess the diagnostic performance of electrophysiology and nerve ultrasound in ulnar neuropathies of varying clinical severity in 135 consecutive patients.

Methods: Clinical severity of ulnar neuropathy was graded on a 4 point scale from very mild (symptoms only) to severe (marked atrophy of intrinsic hand muscles). Sensitivity and localization ability of electrophysiology and nerve ultrasound were assessed for each point of the scale. Read More

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December 2018

Left ventricular hypertrophy is a possible biomarker for early mortality after type B aortic dissection.

J Vasc Surg 2018 Dec 11. Epub 2018 Dec 11.

Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle, Wash. Electronic address:

Objective: Data regarding the cardiac abnormalities associated with Stanford type B aortic dissection (TBAD) and whether these abnormalities are related to outcomes are limited. We describe the prevalence of cardiac abnormalities in patients with TBAD as detected by echocardiography.

Methods: This retrospective review included patients with TBAD presenting between 1990 and 2016. Read More

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December 2018

Update on Insomnia after Mild Traumatic Brain Injury.

Brain Sci 2018 Dec 13;8(12). Epub 2018 Dec 13.

JFK Johnson Rehabilitation Institute, Edison, NJ 08820, USA.

Sleep disturbance after traumatic brain injury (TBI) has received growing interest in recent years, garnering many publications. Insomnia is highly prevalent within the mild traumatic brain injury (mTBI) population and is a subtle, frequently persistent complaint that often goes undiagnosed. For individuals with mTBI, problems with sleep can compromise the recovery process and impede social reintegration. Read More

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December 2018

Fabrication of Stacked Graphene Oxide Nanosheet Membranes Using Triethanolamine as a Crosslinker and Mild Reducing Agent for Water Treatment.

Membranes (Basel) 2018 Dec 13;8(4). Epub 2018 Dec 13.

Center for Membrane and Film Technology, Graduate School of Science, Technology and Innovation, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan.

Two-dimensional (2D) nanosheets show promise for the development of water treatment membranes with extraordinary separation properties and the advantages of atomic thickness with micrometer-sized lateral dimensions. Stacked graphene oxide (GO)-based membranes can demonstrate unique molecular sieving properties with fast water permeation. However, improvements to the structural stability of the membranes in water to avoid problems such as swelling, disruption of the ordered GO layer and decreased rejection are crucial issues. Read More

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December 2018

Driving Cessation and Cognitive Dysfunction in Patients with Mild Cognitive Impairment.

J Clin Med 2018 Dec 13;7(12). Epub 2018 Dec 13.

Department of Neurology, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam-si 13620, Korea.

Although driving by adults with cognitive impairment is an important public health concern, little is known about the indicators of driving cessation in patients with mild cognitive impairment (MCI). We aimed to investigate the prevalence of driving cessation in patients with MCI and the predictive value of cognitive performances for driving cessation. Patients with MCI were recruited in the Seoul National University Bundang Hospital; they met following inclusion criteria. Read More

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December 2018

Amelioration of clinical symptoms of patients with refractory rheumatoid arthritis following treatment with autologous bone marrow-derived mesenchymal stem cells: A successful clinical trial in Iran.

Biomed Pharmacother 2019 Jan 26;109:1834-1840. Epub 2018 Nov 26.

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune arthropathy characterized by synovial hyperplasia leading to functional impairment. Although the exact cause of RA is unknown, there is evidence suggesting the role of T cell subtypes in the pathogenesis of RA. Conventional therapy in some RA patients is associated with mild or severe side effects, and resistance of some patients has been reported to these types of therapy. Read More

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January 2019

Protective effect of Convolvulus pluricaulis against neuroinflammation associated depressive behavior induced by chronic unpredictable mild stress in rat.

Biomed Pharmacother 2019 Jan 20;109:1698-1708. Epub 2018 Nov 20.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, 400 056, India.

Depression is a heterogeneous disorder and has been regarded as an inflammatory disease. The aerial parts of the Convolvulus pluricaulis are used in Indian traditional medicines for the management of nervous disorders. However, the influence of methanolic extract of aerial parts of Convolvulus pluricaulis (CPE) on a chronic animal model of depression has not been investigated yet, and associated biochemical changes are still unclear. Read More

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January 2019

Problem behaviours and Major Depressive Disorder in adults with intellectual disability and autism.

Psychiatry Res 2018 Dec 15;270:769-774. Epub 2018 Oct 15.

CREA (Research and Clinical Centre), San Sebastiano Foundation, Florence Italy. Electronic address:

The high prevalence of Problem Behaviours (PB) in persons with intellectual disability (ID) and Autism Spectrum Disorder (ASD) has been associated by some researchers to a proportionate frequency of Major Depressive Disorder (MDD), which have a different presentation in persons with ID and ASD than in the general population, mostly as behavioural changes. Nevertheless, evidence on this behavioural equivalency is still scarce. The present study aims at evaluating the rate of MDD in persons with ID and ASD presenting PB. Read More

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December 2018
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Increased incidence rate of hypothyroidism after iodine fortification in Denmark. A 20 year prospective population-based study.

J Clin Endocrinol Metab 2018 Dec 14. Epub 2018 Dec 14.

Department of Endocrinology, Aalborg University Hospital, Denmark.

Objective: To monitor the impact of a cautious iodine fortification (IF) on the incidence of overt hypothyroidism in two sub-populations with different levels of preexisting iodine deficiency (ID).

Design: A 20 years (1997-2016) prospective population-based study identified all new cases of diagnosed overt biochemical hypothyroidism in two open cohorts: a Western cohort with moderate ID (n=309,434, January 1st, 1997) and an Eastern cohort with mild ID (n=224,535, January 1st, 1997). A diagnostic algorithm was applied to all thyroid function tests performed within the study areas and possible new cases were verified individually. Read More

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December 2018

Transport of platinum-based pharmaceuticals in water-saturated sand and natural soil: Carboplatin and cisplatin species.

Chemosphere 2018 Dec 4;219:390-399. Epub 2018 Dec 4.

Department of Earth and Planetary Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel.

This study reports the transport characteristics of the pharmaceutical compounds carboplatin and cisplatin, and their respective derivatives, in saturated sand and soil columns. Pharmaceuticals are recognized as emerging pollutants of soil and water resources, but studies of the transport characteristics of organometallic pharmaceuticals in soil-water environments are rare. A recent study of oxaliplatin transport in natural soil raises the question of whether or not its behavior is representative of all Pt-based pharmaceuticals behavior in soil-water systems. Read More

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December 2018

Associations between cognitive impairment and quality of life in euthymic bipolar patients.

Psychiatry Res 2018 Nov 26;271:510-515. Epub 2018 Nov 26.

Department of Psychiatry, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

During the euthymic state in bipolar disorder, cognitive functions often remain affected. Specifically, subjective and objective cognitive impairment might distinctly affect patients' quality of life (QoL); however, this question had not been examined previously in Japanese patients. Therefore, the current study investigated the associations between cognitive complaints, QoL, and objective cognitive functions. Read More

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November 2018
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Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress.

Int Immunopharmacol 2018 Dec 10;67:138-144. Epub 2018 Dec 10.

Institute of Clinical Pharmacy and Pharmacology, Jining First People's Hospital, Jining Medical University, Jining, China. Electronic address:

Increasing evidence suggests that inflammation is related to the pathophysiology of depression. Curcumin (CUR), which is a natural component extracted from the rhizome of Curcuma longa, seems to be efficacious in depression treatment. Hence, the present study aims to explore whether the anti-depressive effect of curcumin is connected to its anti-inflammatory features. Read More

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December 2018

Usefulness of noncontrast MRI in differentiation between gallbladder carcinoma and benign conditions manifesting as focal mild wall thickening.

Clin Imaging 2018 Dec 4;54:63-70. Epub 2018 Dec 4.

Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Magnetic resonance imaging (MRI) is a reliable imaging tool for evaluating gallbladder carcinoma, but it is costly and time-consuming.

Purpose: To compare noncontrast MRI with multidetector row CT (MDCT) and gadoxetic acid-enhanced whole MRI in distinguishing gallbladder carcinoma from benign disease.

Materials And Methods: 101 patients (36 with gallbladder carcinoma and 65 with benign disease) with mild focal gallbladder wall thickening were included. Read More

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December 2018

Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant.

Biomaterials 2018 Dec 10;193:1-11. Epub 2018 Dec 10.

Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China. Electronic address:

Mild heat stimulation can promote the restoration of bone defects but unfortunately, the delivery of exo-hyperthermy into human body is not efficient enough. In this study, mild heat-induced osteogenesis with high efficacy is demonstrated on an osteoimplant composed of black phosphorus nanosheets and poly(lactic-co-glycolic acid) (BPs@PLGA) with the participation of near-infrared (NIR) light irradiation. BPs@PLGA with only 0. Read More

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December 2018
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Supernormal Flicker ERGs in Eyes With Central Retinal Vein Occlusion: Clinical Characteristics, Prognosis, and Effects of Anti-VEGF Agent.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5854-5861

Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Purpose: To determine the clinical characteristics, prognosis, and effect of anti-vascular endothelial growth factor (VEGF) agents on eyes with a central retinal vein occlusion (CRVO) with and without supernormal flicker ERG amplitudes.

Methods: Forty-eight eyes of 48 patients with a CRVO were studied. Flicker ERGs were recorded from fully dilated eyes with the RETeval system. Read More

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December 2018
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SEQUENTIAL CHANGES IN HYDROXYCHLOROQUINE RETINOPATHY UP TO 20 YEARS AFTER STOPPING THE DRUG: Implications for Mild Versus Severe Toxicity.

Retina 2018 Dec 13. Epub 2018 Dec 13.

Byers Eye Institute at Stanford, Palo Alto, California.

Purpose: To characterize the stability or progression of different stages of hydroxychloroquine (HCQ) retinopathy up to 20 years after stopping the drug.

Methods: We reviewed findings from 13 patients with initial HCQ retinopathy classified as early (patchy photoreceptor damage), moderate (ring of photoreceptor thinning or scotoma), or severe (retinal pigment epithelial [RPE] damage). Patients had been off HCQ for as many as 14 years at initial examination and were subsequently followed for 5 years to 8 years with repeated fundus autofluorescence and spectral domain optical coherence tomography. Read More

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December 2018

Clinical Evaluations of a Novel Thread Lifting Regimen Using Barbed Polyglyconate Suture for Facial Rejuvenation: Analysis Using a 3-Dimensional Imaging System.

Dermatol Surg 2018 Dec 13. Epub 2018 Dec 13.

Oaro Dermatology Clinic, Seoul, Republic of Korea.

Background: Thread lifting with absorbable sutures has recently gained prominence for rejuvenating ptotic and sagging soft tissues in aging face. A barbed, delayed absorbable polyglyconate monofilament shows significantly high tensile loads with superior flexibility and elasticity.

Objective: To evaluate the safety and efficacy of novel thread lifting regimen with barbed polyglyconate suture for counteracting the descent and laxity of the aging face. Read More

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December 2018
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Hypogonadotropic hypogonadism and pituitary hypoplasia as recurrent features in Ulnar-Mammary syndrome.

Endocr Connect 2018 Dec;7(12):1432-1441

IRCCS Istituto Auxologico Italiano, Service of Medical Genetics, Milan, Italy.

Ulnar-mammary syndrome (UMS) is characterized by ulnar defects, and nipple or apocrine gland hypoplasia, caused by TBX3 haploinsufficiency. Signs of hypogonadism were repeatedly reported, but the mechanisms remain elusive. We aim to assess the origin of hypogonadism in two families with UMS. Read More

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December 2018

Irradiation-Induced Cobaloxime-Catalyzed C-H Monofluoroalkylation of Styrenes at Room Temperature.

Org Lett 2018 Dec 14. Epub 2018 Dec 14.

Anhui Province Key Laboratory of Advance Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering , Hefei University of Technology , Hefei 230009 , P. R. China.

A cobaloxime-catalyzed photochemical synthesis of allyl monofluorides from styrenes is described herein. This method is characterized by mild reaction conditions, low-cost catalyst, and broad substrate scope. Furthermore, this convenient method will provide a facile synthesis toward novel monofluoroalkylated natural product and pharmaceutical derivatives. Read More

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December 2018

Enoldiazosulfones for Highly Enantioselective [3 + 3]-Cycloaddition with Nitrones Catalyzed by Copper(I) with Chiral BOX Ligands.

Org Lett 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemistry , University of Texas at San Antonio , San Antonio , Texas 78249 , United States.

Enoldiazosulfones undergo [3 + 3]-cycloaddition with nitrones when catalyzed by copper(I) catalysts, but not with dirhodium(II) catalysts. Under mild reaction conditions with chiral bisoxazoline ligands, copper(I) catalysts produce 1,2-oxazine-sulfone derivatives in high yields and enantioselectivities. Dirhodium(II) catalysts form stable donor-acceptor cyclopropenes that undergo uncatalyzed [3 + 2]-cycloaddition reactions with nitrones. Read More

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December 2018

Extended π-Conjugated Structures via Dehydrative C-C Coupling.

J Am Chem Soc 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemistry , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

We describe a methodology for the synthesis of extended aromatic structures through dehydrative C-C coupling from readily accessible diols. Treatment of the diols with a Brønsted acid ( para-toluenesulfonic acid) induces the nucleophilic addition of an arene or heteroarene, yielding fully aromatic products in high to quantitative yields with thiophenes, furan, indole, and N, N-dimethylaniline as coupling partners. The C-C coupling reactions proceed under mild, open flask conditions and offer high atom economy, while providing an attractive alternative approach to metal-catalyzed cross-coupling. Read More

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December 2018

Diastereoselective Photooxidation and Reduction of Chiral Iridium(III) Complexes.

Inorg Chem 2018 Dec 14. Epub 2018 Dec 14.

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry , Sun Yat-sen University , Guangzhou 510275 , China.

A diastereoselective photooxidation of α-amino acid (AA) complexes into imino acid complexes using a chiral iridium(III) complex as a photosensitizer and stereo-controller under visible light irradiation and oxygen was developed. It was found that the oxidative rate of Δ-[Ir(pq)( L-AA)] (pq is 2-phenylquinoline) diastereomer is significantly higher than that of the corresponding Δ-[Ir(pq)( D-AA)] diastereomer, providing a new protocol for kinetic resolution of AAs via a nonenzymatic pathway. Moreover, the thermodynamic controlled strategy offered a complemental method for the diastereoselective hydrogenation of imine bonds using NaBH as a reductant under the chiral Ir(III) complex as a stereo-controller. Read More

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December 2018

[Follow-up research on hearing progression of GJB2 mutation associated hearing loss in children].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1798-1803

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otolaryngology, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing, 100730, China.

To analyze the auditory follow-up alteration of GJB2 associated hearing loss children. Forty three children aged 0-5 years with homozygous or heterozygous mutations of gene attach to the Children' s Hearing Diagnostic Center of our hospital were enrolled in this study. Distortion product otoacoustic emissions and acoustic immittance, auditory brainstem response, auditory steady state response, acoustic impedance, pediatric behavior audiometry and other audiological tests were performed. Read More

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December 2018
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[The application of preoperative pulmonary function and FeNO test in patients with chronic rhinosinusitis].

Authors:
Y Liu A H Yan

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1788-1791

Department of Otorhinolaryngology, the First Hospital of China Medical University, Shenyang, 110001, China.

To explore the application of lung function and exhaled nitric oxide in the evaluation of patients with chronic rhinosinusitis(CRS) with or without polyps who denied bronchial asthma history and planned to undergo endoscopic sinus surgery. Two hundred and thirty-two patients with CRS during April 2016 to April 2018 in our hospital were recruited in this study. All patients accepted lung function and exhaled nitric oxide test before surgery to evaluate whether accompanied with asthma, improvements after standardized drug therapy in patients with asthma. Read More

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December 2018

[Cochlear implant for elder patients over 75 years old].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1477-1479

Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100032, China.

To evaluate the operation safety, hearing as well as speech results of cochlear implantation that were applied in patients over 75 years old. A series of patients who were diagnosed as severe to profound sensorineural hearing loss and received cochlear implantation were admitted. The clinical data and rehabilitation effects of the patients who were over 75 years old were summarized. Read More

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October 2018

[Effects of sleep body posture on subjective sleepiness in patients with OSAHS].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1418-1421

Department of Otorhinolaryngology,the Affiliated Huaian No.1 People's Hospital of Nanjing Medical University,Huaian, 223300, China.

To observe the effects of sleep body posture on subjective sleepiness in patients with OSAHS. We assessed the sleeping body position, the sleep structure, position specific AHI and the Epworth Sleepiness Scale (ESS) in a total of 90 patients with OSAHS. The patients were grouped according to AHI: mild OSAHS (5≤AHI<15), moderate (15≤AHI<30) and severe (AHI≥30). Read More

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September 2018

[Analysis of infants with moderate to severe laryngomalacia].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1406-1409

Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Xiamen University, Xiamen, 361003, China.

To investigate the clinical features and the treatment of moderate-severe laryngeallacia, and the application of CO₂laser supraglotation in laryngeallacia.Collecting the clinical data of 18 infants with moderate-to-severe laryngeallacia diagnosed in our hospital,10 cases were moderate. Eight cases were severe children; according to the classification of laryngeallacia, most of them were mixed type, including 2 cases of type Ⅱ, 3 cases of type Ⅲ, 5 cases of typeⅠ + type Ⅱ, 7 cases of typeⅡ+ type Ⅲ, and 1 case of typeⅠ+ typeⅡ + type Ⅲ. Read More

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September 2018

Dry eye symptoms and associated risk factors among adults aged 50 or more years in Central Mexico.

Salud Publica Mex 2018 Sep-Oct;60(5):520-527

Departamento de Epidemiología Ocular y Salud Visual, Instituto de Oftalmología Conde de Valenciana. Mexico City, Mexico.

Objective: To determine the prevalence of dry eye symptoms (DES) and associated risk factors among adults in Tlaxcala, Mexico.

Materials And Methods: A cross-sectional population-based study that included 1 508 individuals aged ≥50 years who answered the Dry Eye Questionnaire (DEQ5), with a score ranging between 0 and 22; the following categories were defined: no DES (<6); mild-moderate DES (6 to 11) and severe DES (≥12).

Results: The prevalence of DES was 41. Read More

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Acupuncture for Treatment of Persistent Disturbed Sleep: A Randomized Clinical Trial in Veterans With Mild Traumatic Brain Injury and Posttraumatic Stress Disorder.

J Clin Psychiatry 2018 Dec 11;80(1). Epub 2018 Dec 11.

Department of Neurology, Emory Sleep Center, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.

Objective: To evaluate real, as compared with sham, acupuncture in improving persistent sleep disturbance in veterans with mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD).

Methods: This sham-controlled randomized clinical trial at a US Department of Veterans Affairs Medical Center (2010-2015) included 60 veterans aged 24-55 years (mean of 40 years) with history of mTBI of at least 3 months and refractory sleep disturbance. Most of these participants (66. Read More

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December 2018

Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors.

J Clin Psychiatry 2018 Nov 27;80(1). Epub 2018 Nov 27.

Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada.

Objective: Late-life depression has been associated with increased risk of mild cognitive impairment (MCI) and dementia. Predictors of increased risk are incompletely understood. Identification of potentially modifiable risk factors could facilitate prevention of MCI and dementia. Read More

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November 2018