49,784 results match your criteria Mild Cognitive Impairment


The Montreal Cognitive Assessment After Omission of Hearing-Dependent Subtests: Psychometrics and Clinical Recommendations.

J Am Geriatr Soc 2019 Apr 24. Epub 2019 Apr 24.

Department of Psychology, Concordia University, Montréal, Quebec, Canada.

Objectives: Hearing loss (HL) is the third most common chronic health condition in older adults, yet it is often undiagnosed and/or untreated. Given the association between HL and cognitive impairment, it is expected that many people undergoing cognitive screening may have HL. The Montreal Cognitive Assessment (MoCA) is a brief screening test that assesses a wide range of cognitive functions sensitive to Alzheimer's disease (AD) and mild cognitive impairment (MCI). Read More

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http://dx.doi.org/10.1111/jgs.15940DOI Listing

Transcranial Doppler ultrasound in vascular cognitive impairment-no dementia.

PLoS One 2019 24;14(4):e0216162. Epub 2019 Apr 24.

Department of Medical and Surgical Sciences and Advanced Technology, Section of Neurosciences, University of Catania, Catania, Italy.

Background: Although cerebral white matter lesions (WMLs) are considered as a risk factor for vascular dementia, data on their impact on cerebral hemodynamics are scarce. We test and compare transcranial Doppler (TCD) features in WML patients with or without associated cognitive impairment.

Methods: A sample of non-demented elderly patients with WMLs was consecutively recruited. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216162PLOS

Depressive Symptoms in Asymptomatic Stage B Heart Failure with Type II Diabetic Mellitus.

Clin Cardiol 2019 Apr 24. Epub 2019 Apr 24.

Medicine, University of California, La Jolla, CA.

Background: The presence of concomitant Type II diabetic mellitus (T2DM) and depressive symptoms adversely affects individuals with symptomatic heart failure (HF). Hypothesis In presymptomatic Stage B HF, this study hypothesized the presence of greater inflammation and depressive symptoms in T2DM as compared to non-T2DM Stage B patients.

Methods: This cross-sectional study examined clinical parameters, inflammatory biomarkers, and depressive symptoms in 349 T2DM and non-T2DM men with asymptomatic stage B HF (mean age 66. Read More

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http://dx.doi.org/10.1002/clc.23187DOI Listing

[Review on the relationship between selective attention and neural oscillations].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2019 Apr;36(2):320-324

School of Precision Instrument and Opto-electronics Engineering, TianJin University, TianJin 300072, P.R.China;Academy of Medical Engineering and Translational Medicine. TianJin University, TianJin 300072, P.R.China.

Selective attention promotes the perception of brain to outside world and coordinates the allocation of limited brain resources. It is a cognitive process which relies on the neural activities of attention-related brain network. As one of the important forms of brain activities, neural oscillations are closely related to selective attention. Read More

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http://dx.doi.org/10.7507/1001-5515.201808052DOI Listing

Targeting Cancer Via Resveratrol-Loaded Nanoparticles Administration: Focusing on In Vivo Evidence.

AAPS J 2019 Apr 23;21(4):57. Epub 2019 Apr 23.

Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.

Resveratrol (RSV) is a polyphenol endowed with potential therapeutic effects in chronic diseases, particularly in cancer, the second leading cause of death worldwide in the twenty-first century. The advent of nanotechnology application in the field of drug delivery allows to overcome the constrains associated with the conventional anticancer treatments, in particular chemotherapy, reducing its adverse side effects, off target risks and surpassing cancer multidrug chemoresistance. Moreover, the use of nanotechnology-based carriers in the delivery of plant-derived anticancer agents, such as RSV, has already demonstrated to surpass the poor water solubility, instability and reduced bioavailability associated with phytochemicals, improving their therapeutic activity, thus prompting pharmaceutical developments. Read More

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http://dx.doi.org/10.1208/s12248-019-0325-yDOI Listing

Enhanced interleukin-8 production in mononuclear cells in severe pediatric obstructive sleep apnea.

Allergy Asthma Clin Immunol 2019 16;15:23. Epub 2019 Apr 16.

2Department of Anesthesia, McGill University Health Center, 1001 Decarie Boulevard, Montreal, QC H4A 3J1 Canada.

Background: Obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease, metabolic disorders, and cognitive dysfunction. Current thinking links chronic intermittent hypoxia (CIH) with oxidative stress and systemic inflammation. However, the sequence of events leading to the morbidities associated with OSA is poorly understood in children. Read More

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https://aacijournal.biomedcentral.com/articles/10.1186/s1322
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http://dx.doi.org/10.1186/s13223-019-0338-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469051PMC
April 2019
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Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.

Redox Biol 2019 Apr 10;24:101192. Epub 2019 Apr 10.

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary; Department of Public Health, Semmelweis University, Budapest, Hungary; Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address:

Adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling (NVC) has an essential role in maintenance of healthy cognitive function. In aging increased oxidative stress and cerebromicrovascular endothelial dysfunction impair NVC, contributing to cognitive decline. There is increasing evidence showing that a decrease in NAD availability with age plays a critical role in a range of age-related cellular impairments but its role in impaired NVC responses remains unexplored. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101192DOI Listing

Estimation of cumulative number of post-treatment Lyme disease cases in the US, 2016 and 2020.

BMC Public Health 2019 Apr 24;19(1):352. Epub 2019 Apr 24.

, Greenwich, CT, USA.

Background: Lyme disease (LD) is an infectious multi-system illness caused by the bacterial genus Borrelia and spread by bites of infected ticks. Although most patients are successfully treated by timely antibiotic therapy, it is broadly accepted that a sizeable number of patients experience treatment failure and continue to suffer long-term, debilitating symptoms, including pain, fatigue, cognitive dysfunction and other symptoms. This is known as post-treatment LD (PTLD), for which diagnosis is not standardized and treatment remains controversial. Read More

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https://bmcpublichealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12889-019-6681-9DOI Listing
April 2019
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Female versus male migraine: an event-related potential study of visual neurocognitive processing.

J Headache Pain 2019 Apr 23;20(1):38. Epub 2019 Apr 23.

Department of Senile Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, Shandong, People's Republic of China.

Background: Several studies have suggested cognitive deficits in migraineurs, and sex differences have also been observed in migraine, such as a higher prevalence in females. Nevertheless, little is known about gender-related differences in cognitive processing. In this study, we aimed to investigate the effect of gender on neurocognitive processing in migraineurs. Read More

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http://dx.doi.org/10.1186/s10194-019-0995-yDOI Listing

The incremental value of neuropsychological assessment: a critical review.

Authors:
Jacobus Donders

Clin Neuropsychol 2019 Apr 23:1-32. Epub 2019 Apr 23.

a Department of Psychology , Mary Free Bed Rehabilitation Hospital , Grand Rapids , MI , USA.

Objective: The purpose of this critical review was to evaluate the current state of research regarding the incremental value of neuropsychological assessment in clinical practice, above and beyond what can be accounted for on the basis of demographic, medical, and other diagnostic variables. The focus was on neurological and other medical conditions across the lifespan where there is known risk for presence or future development of cognitive impairment.

Method: Eligible investigations were group studies that had been published after 01/01/2000 in English in peer-reviewed journals and that had used standardized neuropsychological measures and reported on objective outcome criterion variables. Read More

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http://dx.doi.org/10.1080/13854046.2019.1575471DOI Listing

Dexmedetomidine improves cognition after carotid endarterectomy by inhibiting cerebral inflammation and enhancing brain-derived neurotrophic factor expression.

J Int Med Res 2019 Apr 24:300060519843738. Epub 2019 Apr 24.

1 Department of Anesthesiology, Northern Jiangsu People's Hospital, Yangzhou City, Jiangsu Province, China.

Objectives: Carotid endarterectomy (CEA) is efficient in preventing stroke for patients with significant carotid stenosis, but results in mild cognitive dysfunction. Dexmedetomidine is neuroprotective in stroke models. We hypothesized that dexmedetomidine may improve cognition after CEA. Read More

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http://dx.doi.org/10.1177/0300060519843738DOI Listing

Comparative study of two Chinese versions of Montreal Cognitive Assessment for Screening of Mild Cognitive Impairment.

Appl Neuropsychol Adult 2019 Apr 23:1-6. Epub 2019 Apr 23.

c Department of Gerontology , Shanghai Jiaotong University Affiliated Sixth People's Hospital , Shanghai , China.

Our aim was to compare the utility and accuracy of the Chinese Version of Montreal Cognitive Assessment Basic (MoCA-BC) and the Montreal Cognitive Assessment-Beijing Version (MoCA-BJ) in the identification of mild cognitive impairment (MCI) under different education levels. A sample of individuals with MCI (n = 295), Alzheimer's disease (AD; n = 254), and normal controls (NC; n = 259) at 2 Memory Clinics and communities was administered the MoCA-BC, MoCA-BJ, Mini-Mental State Examination (MMSE), and other neuropsychological tests. The discriminant validity of the MoCA-BC and MoCA-BJ as diagnostic instruments was ascertained. Read More

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http://dx.doi.org/10.1080/23279095.2019.1602530DOI Listing

Neuroimaging Studies on Disorders of Consciousness: A Meta-Analytic Evaluation.

J Clin Med 2019 Apr 16;8(4). Epub 2019 Apr 16.

NeuroMi, Milan Center for Neuroscience, 20126 Milano, Italy.

Neuroimaging tools could open a window on residual neurofunctional activity in the absence of detectable behavioural responses in patients with disorders of consciousness (DOC). Nevertheless, the literature on this topic is characterised by a large heterogeneity of paradigms and methodological approaches that can undermine the reproducibility of the results. To explicitly test whether task-related functional magnetic resonance imaging (fMRI) can be used to systematically detect neurofunctional differences between different classes of DOC, and whether these differences are related with a specific category of cognitive tasks (either active or passive), we meta-analyzed 22 neuroimaging studies published between 2005 and 2017 using the Activation Likelihood Estimate method. Read More

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http://dx.doi.org/10.3390/jcm8040516DOI Listing

Protects d-Galactose/AlCl Mediated Alzheimer's Disease-Like Rats via PP2A/GSK-3β Signaling Pathway in Their Hippocampus.

Int J Mol Sci 2019 Apr 16;20(8). Epub 2019 Apr 16.

Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder more prevalent among the elderly population. AD is characterised clinically by a progressive decline in cognitive functions and pathologically by the presence of neurofibrillary tangles (NFTs), deposition of beta-amyloid (Aβ) plaque and synaptic dysfunction in the brain. (CA) is a valuable herb being used widely in African, Ayurvedic, and Chinese traditional medicine to reverse cognitive impairment and to enhance cognitive functions. Read More

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http://dx.doi.org/10.3390/ijms20081871DOI Listing

Associations of Lipophilic Micronutrients with Physical and Cognitive Fitness in Persons with Mild Cognitive Impairment.

Nutrients 2019 Apr 22;11(4). Epub 2019 Apr 22.

Ageing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, 50931 Cologne, Germany.

Age-associated cognitive impairment in general and dementia in particular are a global concern. Preventive lifestyle strategies are highly used but there is a lack of information on the reciprocal relationships between nutrition biomarkers and measures of both cognitive and physical performance. To fill this gap of knowledge, the relationship between plasma levels of the robust nutrition- and antioxidant defense-related biomarkers carotenoid and tocopherols and both indicators of cognitive and physical performance was investigated in a group of persons with mild cognitive impairment participating in the NeuroExercise Study at the German Sport University in Cologne, Germany. Read More

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http://dx.doi.org/10.3390/nu11040902DOI Listing

Ameliorative Effects of on Cognitive Impairment Via Enhancing Cholinergic Functions and Brain-Derived Neurotrophic Factor Expression in -Amyloid-Induced Mice.

J Med Food 2019 Apr 23. Epub 2019 Apr 23.

1 Department of Biochemistry and Molecular Biology, Center for Chronic Metabolic Disease Research, Brain Korea 21 Project for Medical Sciences, Severance Medical Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Alzheimer's disease accounts for the majority of dementia and shows hallmarks such as sequential cognitive dysfunction and abnormal behavior. (DM) has traditionally been used to treat a variety of diseases in East Asia. The aim of this study was to assess the therapeutic effects of DM on brain neuron damage and on cognitive deficit in neuronal cell induced by A in mice. Read More

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http://dx.doi.org/10.1089/jmf.2018.4375DOI Listing

Assessment of cognitive profile as a prodromal marker of the evolution of REM sleep Behavior Disorder.

Sleep 2019 Apr 23. Epub 2019 Apr 23.

Unit of Sleep Medicine and Epilepsy, IRCCS Mondino Foundation, Pavia, Italy.

Study Objectives: To search for a specific neuropsychological profile in idiopathic REM sleep Behavior Disorder (iRBD), able to predict the onset of neurodegenerative disorders.

Methods: In a longitudinal follow-up study of 63 consecutive iRBD patients (follow-up duration 6.7± 3. Read More

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http://dx.doi.org/10.1093/sleep/zsz103DOI Listing

The effectiveness of diverse technology-based instructions in assisting people with Alzheimer's disease with medication management.

Disabil Rehabil Assist Technol 2019 Apr 23:1-9. Epub 2019 Apr 23.

c Department of Rehabilitation , Heisei College of Health Sciences , Gifu , Japan.

Purpose: In patients with mild cognitive impairment and Alzheimer's disease (AD), faculties associated with instrumental activities of daily living (IADL) decline owing to reduced cognitive function. One type of IADL is medication behaviour. Medication management is critical for patients with AD. Read More

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http://dx.doi.org/10.1080/17483107.2019.1594405DOI Listing
April 2019
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Intrinsic connectivity identifies the sensory-motor network as a main cross-network between remitted late-life depression- and amnestic mild cognitive impairment-targeted networks.

Brain Imaging Behav 2019 Apr 23. Epub 2019 Apr 23.

Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.

Remitted late-life depression (rLLD) and amnestic mild cognitive impairment (aMCI) are both associated with a high risk of developing Alzheimer's disease (AD). Neurodegeneration is considered to spread within pre-existing networks. To investigate whether, in the healthy brain, there was a pre-existing cross-network between the intrinsic networks that are vulnerable to rLLD and aMCI. Read More

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http://dx.doi.org/10.1007/s11682-019-00098-4DOI Listing

Differential insular cortex sub-regional atrophy in neurodegenerative diseases: a systematic review and meta-analysis.

Brain Imaging Behav 2019 Apr 23. Epub 2019 Apr 23.

Department of Anatomy and Neurosciences, Section Clinical Neuroanatomy and Biobanking, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, De Boelelaan 1108, 1081 HZ, Amsterdam, Netherlands.

The insular cortex is proposed to function as a central brain hub characterized by wide-spread connections and diverse functional roles. As a result, its centrality in the brain confers high metabolic demands predisposing it to dysfunction in disease. However, the functional profile and vulnerability to degeneration varies across the insular sub-regions. Read More

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http://dx.doi.org/10.1007/s11682-019-00099-3DOI Listing

Olfactory anosognosia is a predictor of cognitive decline and dementia conversion in Parkinson's disease.

J Neurol 2019 Apr 22. Epub 2019 Apr 22.

Department of Neurology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.

Objective: Parkinson's disease (PD) patients are often unaware of olfactory deficits despite having hyposmia from the early stages. We aimed to evaluate whether olfactory anosognosia is a predictor of cognitive decline in PD.

Methods: In this retrospective cohort study, we recruited 77 PD patients who underwent both olfactory and neuropsychological tests and were followed-up for over 5 years. Read More

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http://dx.doi.org/10.1007/s00415-019-09297-xDOI Listing
April 2019
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General and domain-specific cognitive reserve, mild cognitive impairment, and dementia risk in older women.

Alzheimers Dement (N Y) 2019 10;5:118-128. Epub 2019 Apr 10.

Department of Neurology, University of Southern California, Los Angeles, CA, USA.

Introduction: In a geographically diverse sample of women, we asked whether cognitive reserve (CR) is best viewed as a general or cognitive domain-specific construct and whether some cognitive reserve domains but not others exert protective effects on risk of developing mild cognitive impairment (MCI) or dementia.

Methods: Estimates of general and domain-specific CR were derived via variance decomposition in 972 cognitively intact women from the Women's Health Initiative Study of Cognitive Aging and Women's Health Memory Study Magnetic Resonance Imaging. Women were then followed up for 13 years. Read More

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http://dx.doi.org/10.1016/j.trci.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461572PMC

The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study.

Alzheimers Dement (Amst) 2019 Dec 12;11:310-326. Epub 2019 Apr 12.

Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.

Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies.

Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. Read More

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http://dx.doi.org/10.1016/j.dadm.2019.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465616PMC
December 2019

Aberrant Interhemispheric Functional Organization in Children with Dyskinetic Cerebral Palsy.

Biomed Res Int 2019 18;2019:4362539. Epub 2019 Mar 18.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu 610054, China.

Background: Hemispheric asymmetry is one fundamental principle of neuronal organization. Interhemispheric connectivity and lateralization of intrinsic networks in the resting-state brain demonstrate the interhemispheric functional organization and can be affected by disease processes. This study aims to investigate the interhemispheric organization in children with dyskinetic cerebral palsy (DCP) based on resting-state functional MRI (fMRI). Read More

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http://dx.doi.org/10.1155/2019/4362539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442313PMC

Cerebrospinal Fluid Biomarkers for the Diagnosis of Prodromal Alzheimer's Disease in Amnestic Mild Cognitive Impairment.

Dement Geriatr Cogn Dis Extra 2019 Jan-Apr;9(1):100-113. Epub 2019 Mar 12.

Department of Biomedical Science, Chosun University, Gwangju, Republic of Korea.

Background/aims: Disease-modifying therapy for Alzheimer's disease (AD) has led to a need for biomarkers to identify prodromal AD and very early stage of AD dementia. We aimed to identify the cutoff values of cerebrospinal fluid (CSF) biomarkers for detecting prodromal AD.

Methods: We assessed 56 patients with amnestic mild cognitive impairment (aMCI) who underwent lumbar puncture. Read More

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http://dx.doi.org/10.1159/000496920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465729PMC
March 2019
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Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice.

Mediators Inflamm 2019 18;2019:8301725. Epub 2019 Mar 18.

Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, China.

Postoperative cognitive dysfunction (POCD) is defined as new cognitive impairment (memory impairment and impaired performance) after surgery, especially in aged patients. Sleep disturbance is a common phenomenon before surgery that has been increasingly thought to affect patient recovery. However, little is known about the functional impact of preoperative sleep disturbance on POCD. Read More

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http://dx.doi.org/10.1155/2019/8301725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442479PMC

Altered Functional Brain Connectivity in Mild Cognitive Impairment during a Cognitively Complex Car Following Task.

Geriatrics (Basel) 2018 Apr 19;3(2). Epub 2018 Apr 19.

Neuroscience Research Program, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON M5B 1T8, Canada.

Mild cognitive impairment (MCI) can affect multiple cognitive abilities, leading to difficulty in performing complex, cognitively demanding daily tasks, such as driving. This study combined driving simulation and functional magnetic resonance imaging (fMRI) to investigate brain function in individuals with MCI while they performed a car-following task. The behavioral driving performance of 24 patients with MCI and 20 healthy age-matched controls was compared during a simulated car-following task. Read More

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http://dx.doi.org/10.3390/geriatrics3020020DOI Listing

Cerebral Ischemia and Cognitive Dysfunction in Patients on Dialysis.

Clin J Am Soc Nephrol 2019 Apr 22. Epub 2019 Apr 22.

Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; and.

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http://dx.doi.org/10.2215/CJN.00400119DOI Listing

Preventing adolescent stress-induced cognitive and microbiome changes by diet.

Proc Natl Acad Sci U S A 2019 Apr 22. Epub 2019 Apr 22.

Department of Health Sciences, Universitá di Firenze, 50121 Florence, Italy;

Psychological stress during adolescence may cause enduring cognitive deficits and anxiety in both humans and animals, accompanied by rearrangement of numerous brain structures and functions. A healthy diet is essential for proper brain development and maintenance of optimal cognitive functions during adulthood. Furthermore, nutritional components profoundly affect the intestinal community of microbes that may affect gut-brain communication. Read More

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http://dx.doi.org/10.1073/pnas.1820832116DOI Listing

Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer's Disease.

Alzheimers Res Ther 2019 Apr 22;11(1):34. Epub 2019 Apr 22.

Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.

The cerebrospinal fluid (CSF) biochemical markers (biomarkers) Amyloidβ 42 (Aβ), total Tau (T-tau) and Tau phosphorylated at threonine 181 (P-tau) have proven diagnostic accuracy for mild cognitive impairment and dementia due to Alzheimer's Disease (AD). In an effort to improve the accuracy of an AD diagnosis, it is important to be able to distinguish between AD and other types of dementia (non-AD). The concentration ratio of Aβ to Aβ (Aβ Ratio) has been suggested to be superior to the concentration of Aβ alone when identifying patients with AD. Read More

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http://dx.doi.org/10.1186/s13195-019-0485-0DOI Listing

Exploring the Roles of Central and Peripheral Nervous System Function in Gait Stability: Preliminary Insights from Cancer Survivors.

Gait Posture 2019 Apr 6;71:62-68. Epub 2019 Apr 6.

Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, USA; School of Health & Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA.

Background: Impairments in central and/or peripheral nervous systems are known to be associated with altered gait; however, the interplay between cognitive function, peripheral sensation, and orbital gait stability remains largely unclear. Elucidating these relationships is expected to provide a clearer understanding of potential fall risk factors across various populations and targets for novel interventions. Many patients diagnosed with cancer are treated with chemotherapy agents known to be neurotoxic to the central and/or peripheral nervous systems that can contribute to movement deficiencies, making this population a novel model to investigate these relationships. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09666362183163
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http://dx.doi.org/10.1016/j.gaitpost.2019.04.002DOI Listing
April 2019
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Analysis of covariance (ANCOVA) in randomized trials: More precision and valid confidence intervals, without model assumptions.

Biometrics 2019 Apr 22. Epub 2019 Apr 22.

Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Maryland 21205, Baltimore, USA.

"Covariate adjustment" in the randomized trial context refers to an estimator of the average treatment effect that adjusts for chance imbalances between study arms in baseline variables (called "covariates"). The baseline variables could include, e.g. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/biom.13062
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http://dx.doi.org/10.1111/biom.13062DOI Listing
April 2019
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A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia.

Brain 2019 Apr 22. Epub 2019 Apr 22.

Avid Radiopharmaceuticals, Philadelphia, PA, USA.

The advent of tau-targeted PET tracers such as flortaucipir (18F) (flortaucipir, also known as 18F-AV-1451 or 18F-T807) have made it possible to investigate the sequence of development of tau in relationship to age, amyloid-β, and to the development of cognitive impairment due to Alzheimer's disease. Here we report a multicentre longitudinal evaluation of the relationships between baseline tau, tau change and cognitive change, using flortaucipir PET imaging. A total of 202 participants 50 years old or older, including 57 cognitively normal subjects, 97 clinically defined mild cognitive impairment and 48 possible or probable Alzheimer's disease dementia patients, received flortaucipir PET scans of 20 min in duration beginning 80 min after intravenous administration of 370 MBq flortaucipir (18F). Read More

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http://dx.doi.org/10.1093/brain/awz090DOI Listing

Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer Disease.

JAMA Neurol 2019 Apr 22. Epub 2019 Apr 22.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

Importance: Plasma neurofilament light (NfL) has been suggested as a noninvasive biomarker to monitor neurodegeneration in Alzheimer disease (AD), but studies are lacking.

Objective: To examine whether longitudinal plasma NfL levels are associated with other hallmarks of AD.

Design, Setting, And Participants: This North American cohort study used data from 1583 individuals in the multicenter Alzheimer's Disease Neuroimaging Initiative study from September 7, 2005, through June 16, 2016. Read More

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http://dx.doi.org/10.1001/jamaneurol.2019.0765DOI Listing
April 2019
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PPAR-δ Activation Ameliorates Diabetes-Induced Cognitive Dysfunction by Modulating Integrin-linked Kinase and AMPA Receptor Function.

J Am Coll Nutr 2019 Apr 22:1-10. Epub 2019 Apr 22.

a Department of Drug Discovery and Development, Harrison School of Pharmacy , Auburn University , Auburn , Alabama , USA.

An estimated 9% of the American population experiences type II diabetes mellitus (T2DM) due to diet or genetic predisposition. Recent reports indicate that patients with T2DM are at increased risk for cognitive dysfunctions, as observed in conditions like Alzheimer's disease (AD). In addition, AD is the leading cause of dementia, highlighting the urgency of developing novel therapeutic targets for T2DM-induced cognitive deficits. Read More

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http://dx.doi.org/10.1080/07315724.2019.1598307DOI Listing

The Occurrence of Postoperative Cognitive Dysfunction (POCD) - Systematic Review.

Psychiatr Pol 2019 Feb 28;53(1):145-160. Epub 2019 Feb 28.

Gdański Uniwersytet Medyczny, Zakład Pielęgniarstwa Anestezjologicznego i Intensywnej Opieki.

Aim: The aim of this systematic review was to summarize the present literature on cognitive dysfunctions in adults after surgical procedures.

Methods: MEDLINE: PubMed, OVID, Web of Science, EBSCO databases have been searched using relevant key words. The literature on cognitive dysfunctions after surgical procedures has been reviewed and the risk factors of POCD occurrence have been analyzed. Read More

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http://dx.doi.org/10.12740/PP/90648DOI Listing
February 2019

Daily Sodium Monitoring and Fluid Intake Protocol: Preventing Recurrent Hospitalization in Adipsic Diabetes Insipidus.

J Endocr Soc 2019 May 18;3(5):882-886. Epub 2019 Mar 18.

Division of Endocrinology, Diabetes and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Management of diabetes insipidus (DI) is usually facilitated by an intact thirst mechanism prompting water ingestion in times of rising osmolality. Maintenance of eunatremia can be quite difficult in patients with DI and adipsia because of the absence of this homeostatic mechanism. Few published protocols for management of these complex cases exist. Read More

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http://dx.doi.org/10.1210/js.2018-00406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467390PMC

Targeting the Blood-Brain Barrier to Prevent Sepsis-Associated Cognitive Impairment.

J Cent Nerv Syst Dis 2019 9;11:1179573519840652. Epub 2019 Apr 9.

Graduate Programs in Neuroscience, Department of Neuroscience, School of Medicine, Health Sciences Center, West Virginia University, Morgantown, WV, USA.

Sepsis is a systemic inflammatory disease resulting from an infection. This disorder affects 750 000 people annually in the United States and has a 62% rehospitalization rate. Septic symptoms range from typical flu-like symptoms (eg, headache, fever) to a multifactorial syndrome known as sepsis-associated encephalopathy (SAE). Read More

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http://dx.doi.org/10.1177/1179573519840652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456845PMC

Microglia in the Neurovascular Unit: Blood-Brain Barrier-microglia Interactions After Central Nervous System Disorders.

Neuroscience 2019 May 6;405:55-67. Epub 2018 Jul 6.

Faculty of Biology, Medicine and Health, AV Hill Building, The University of Manchester, United Kingdom. Electronic address:

Over the past few decades, microglial cells have been regarded as the main executor of inflammation after acute and chronic central nervous system (CNS) disorders, responding rapidly to exogenous stimuli during acute trauma or infections, or signals released by cells undergoing cell death during conditions such as stroke, Alzheimer's disease (AD) and Parkinson's disease (PD). Barriers of the nervous system, and in particular the blood-brain barrier (BBB), play a key role in the normal physiological and cognitive functions of the brain. Being at the interface between the central and peripheral compartment, the BBB is regarded as a sensor of homeostasis, and any disruption within the brain or the systemic compartment triggers BBB dysfunction and neuroinflammation, both contributing to the pathogenesis of cerebrovascular disease. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2018.06.046DOI Listing

Prospective memory assessment in acute mild traumatic brain injury.

Clin Neuropsychol 2019 Apr 22:1-20. Epub 2019 Apr 22.

a Department of Psychology , Université du Québec à Montréal , Montreal , Canada.

Objective: Prospective memory (PM) is the ability to remember to perform an intention at the appropriate time in the future. It is of primary importance for daily living, and its disruption may impact functional autonomy. To date, few studies have examined PM during the acute phase of mild traumatic brain injury (mTBI), despite the high prevalence of this neurological condition and its potential impact on cognition. Read More

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https://www.tandfonline.com/doi/full/10.1080/13854046.2019.1
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http://dx.doi.org/10.1080/13854046.2019.1598500DOI Listing
April 2019
1 Read

A meta-analysis on verbal working memory in children and adolescents with ADHD.

Clin Neuropsychol 2019 Apr 22:1-26. Epub 2019 Apr 22.

b Department of Psychology , University of Otago , Dunedin , New Zealand.

Objective: Previous meta-analyses have demonstrated verbal working memory (WM) dysfunction in children and adolescents with attention deficit/hyperactivity disorder (ADHD); however, the findings are inconsistent. The main objective of this meta-analysis was to investigate the performance of children and adolescents with ADHD in the Digit Span Backwards (DSB) subtest from the Wechsler Intelligence Scale for Children or Wechsler Adult Intelligence Scale. We also sought to provide an updated meta-analysis on WM in children and adolescents with ADHD. Read More

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http://dx.doi.org/10.1080/13854046.2019.1604998DOI Listing

Tired and lack focus? Insomnia increases distractibility.

J Health Psychol 2019 Apr 22:1359105319842927. Epub 2019 Apr 22.

1 CIRUS, Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, NSW, Australia.

Chronic insomnia is associated with subjective daytime cognitive dysfunction, but objective corroborative data are often lacking. In this study, we use Perceptual Load Theory to objectively assess distractibility in participants with insomnia ( N = 23) compared with age- and sex-matched controls ( N = 23). Following overnight supervised sleep observation, all participants completed a selective attention task which varied in the level of perceptual load and distractor congruency. Read More

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http://dx.doi.org/10.1177/1359105319842927DOI Listing

Associations between sleep duration and cognitive impairment in mild cognitive impairment.

J Sleep Res 2019 Apr 21:e12864. Epub 2019 Apr 21.

Clinic of Social and Family Medicine, School of Medicine, University of Crete, Heraklion, Crete, Greece.

The prevalence of mild cognitive impairment (MCI) increases among elderly people and is associated with a high risk of dementia. Identifying factors that may contribute to the progress of MCI to dementia is critical. The objective of this study was to examine the association of objective sleep with cognitive performance in MCI patients. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jsr.12864
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http://dx.doi.org/10.1111/jsr.12864DOI Listing
April 2019
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Structural correlates of attention dysfunction in Lewy body dementia and Alzheimer's disease: an ex-Gaussian analysis.

J Neurol 2019 Apr 21. Epub 2019 Apr 21.

Institute of Neuroscience, Newcastle University, Biomedical Research Building 3rd Floor, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.

Background: Lewy body dementia (LBD) and Alzheimer's disease (AD) are common forms of degenerative dementia. While they are characterized by different clinical profiles, attentional deficits are a common feature. The objective of this study was to investigate how attentional problems in LBD and AD differentially affect different aspects of reaction time performance and to identify possible structural neural correlates. Read More

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http://dx.doi.org/10.1007/s00415-019-09323-yDOI Listing

Frontal dynamic activity as a predictor of cognitive dysfunction after pontine ischemia.

Authors:
Shigeru Obayashi

NeuroRehabilitation 2019 ;44(2):251-261

Department of Rehabilitation Medicine, Dokkyo Medical University Saitama Medical Center, Japan.

BACKGROUNDThere is a tendency to pay little attention to cognitive dysfunction after a subcortical stroke, resulting in this condition being overlooked. Damage to the brainstem may affect cognition, probably originating from the fronto-cerebellar circuit, but details remain obscure.OBJECTIVETo investigate the effect of damage to pons on frontal function via the fronto-cerebellar circuit. Read More

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http://dx.doi.org/10.3233/NRE-182566DOI Listing
January 2019

Total Cerebral Small Vessel Disease Burden Is Related to Worse Performance on the Mini-Mental State Examination and Incident Dementia: A Prospective 5-Year Follow-Up.

J Alzheimers Dis 2019 Apr 15. Epub 2019 Apr 15.

State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.

Individual cerebral small vessel disease (CSVD) may cause cognitive decline. However, the association between total burden of CSVD and cognitive deterioration in the general population remains unclear. We aimed to determine whether total CSVD score is associated with cognitive performance change and incident dementia in the general population. Read More

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http://dx.doi.org/10.3233/JAD-181135DOI Listing

Pre-administration of luteoline attenuates neonatal sevoflurane-induced neurotoxicity in mice.

Acta Histochem 2019 Apr 18. Epub 2019 Apr 18.

Department of Anesthesiology, The Second Hospital of Dalian Medical University, Dalian, 116027, People's Republic of China. Electronic address:

Sevoflurane is a widely used inhaled anesthetic, which triggers neuroapoptosis and oxidative damage in the developing central nervous system and cognitive dysfunction later in life. However, no effective therapeutic strategy for sevoflurane-induced deleterious effects is well developed. The purpose of the present study was to explore whether luteoline could attenuate neonatal sevoflurane exposure-triggered neurotoxicity. Read More

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http://dx.doi.org/10.1016/j.acthis.2019.04.004DOI Listing

Sleep quality mediates the relationship between frailty and cognitive dysfunction in non-demented middle aged to older adults.

Int Psychogeriatr 2019 Apr 22:1-10. Epub 2019 Apr 22.

Department of Neurology,University of Miami Miller School of Medicine, Miami, FL,USA.

ABSTRACTObjectives:Frailty is associated with cognitive decline in older adults. However, the mechanisms explaining this relationship are poorly understood. We hypothesized that sleep quality may mediate the relationship between frailty and cognition. Read More

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http://dx.doi.org/10.1017/S1041610219000292DOI Listing

The effect of subjective perception of cognition on emotional functioning in adults with long-term neurological and neuropsychiatric disorders.

Disabil Rehabil 2019 Apr 21:1-7. Epub 2019 Apr 21.

a Department of Psychology , California State University , Northridge , CA , USA.

Purpose: To examine effects of subjective perception and objective status of cognition on emotional functioning in a sample of adults with long-term neurological and neuropsychiatric disorders.

Method: N = 65. Subjective measures were derived from the self-ratings on the Problem Checklist (PCL) from the HI-FI; the objective status was represented by combined externally standardised scores on neuropsychological tests across three cognitive domains: verbal memory, executive functioning, and psychomotor speed. Read More

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http://dx.doi.org/10.1080/09638288.2019.1585490DOI Listing

[Effect of apolipoprotein E genotype on magnetic resonance spectrum in amnestic mild cognitive impairment and Alzheimer's disease patients].

Zhonghua Yi Xue Za Zhi 2019 Apr;99(15):1156-1161

Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.

To explore the relationship between apolipoprotein E (ApoE) gene polymorphism and hydrogen proton magnetic resonance spectroscopy ((1)H-MRS) in patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment(aMCI). The cognitive function of 35 AD patients (AD group), 35 aMCI patients (aMCI group) and 36 normal controls (NC group) were evaluated by neuropsychological scales, including Mini-mental State Examination (MMSE) and Cambridge Cognitive Examination-Chinese version (CAMCOG-C). The genotypes of ApoE were analyzed by high-resolution melting assay. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.15.008DOI Listing