48,501 results match your criteria Mild Cognitive Impairment


Palmitate and Stearate are Increased in the Plasma in a 6-OHDA Model of Parkinson's Disease.

Metabolites 2019 Feb 13;9(2). Epub 2019 Feb 13.

Institute of Pharmaceutical Science, Faculty of Life Sciences and Medicine, King's College London, London SE19NH, UK.

Introduction: Parkinson's disease (PD) is the second most common neurodegenerative disorder, without any widely available curative therapy. Metabolomics is a powerful tool which can be used to identify unexpected pathway-related disease progression and pathophysiological mechanisms. In this study, metabolomics in brain, plasma and liver was investigated in an experimental PD model, to discover small molecules that are associated with dopaminergic cell loss. Read More

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http://dx.doi.org/10.3390/metabo9020031DOI Listing
February 2019

Loss of C/EBPδ Exacerbates Radiation-Induced Cognitive Decline in Aged Mice due to Impaired Oxidative Stress Response.

Int J Mol Sci 2019 Feb 18;20(4). Epub 2019 Feb 18.

Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Aging is characterized by increased inflammation and deterioration of the cellular stress responses such as the oxidant/antioxidant equilibrium, DNA damage repair fidelity, and telomeric attrition. All these factors contribute to the increased radiation sensitivity in the elderly as shown by epidemiological studies of the Japanese atomic bomb survivors. There is a global increase in the aging population, who may be at increased risk of exposure to ionizing radiation (IR) as part of cancer therapy or accidental exposure. Read More

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http://dx.doi.org/10.3390/ijms20040885DOI Listing
February 2019

Insulin Resistance and Oxidative Stress in the Brain: What's New?

Int J Mol Sci 2019 Feb 18;20(4). Epub 2019 Feb 18.

Department of Physiology, Medical University of Bialystok, Mickiewicza 2c Str., 15-222 Bialystok, Poland.

The latest studies have indicated a strong relationship between systemic insulin resistance (IR) and higher incidence of neurodegeneration, dementia, and mild cognitive impairment. Although some of these abnormalities could be explained by chronic hyperglycaemia, hyperinsulinemia, dyslipidaemia, and/or prolonged whole-body inflammation, the key role is attributed to the neuronal redox imbalance and oxidative damage. In this mini review, we provide a schematic overview of intracellular oxidative stress and mitochondrial abnormalities in the IR brain. Read More

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http://dx.doi.org/10.3390/ijms20040874DOI Listing
February 2019

Are subsyndromal manifestations of attention deficit hyperactivity disorder morbid in children? A systematic qualitative review of the literature with meta-analysis.

Psychiatry Res 2019 Feb 3;274:75-90. Epub 2019 Feb 3.

Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address:

We conducted a qualitative review (n = 15 manuscripts) and meta-analysis (n = 9 manuscripts) of the extant literature to evaluate the prevalence and morbidity of subthreshold Attention Deficit Hyperactivity Disorder (ADHD). Our qualitative review showed that a sizable minority (mean: 17.7%) of clinically referred and non-referred children met a priori definitions of subthreshold ADHD. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.003DOI Listing
February 2019

REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation.

Behav Brain Res 2019 Feb 16. Epub 2019 Feb 16.

Department of Anesthesiology, Renmin hospital of Wuhan University, Wuhan, 430060, Hubei Province, China. Electronic address:

Sleep disturbance can result in memory impairment, and both sleep and hippocampal memory formation are maintained by circadian clock genes. Although preoperative sleep deprivation is known to be an independent risk factor for postoperative cognitive dysfunction (POCD) after inhalation anesthesia, the circadian mechanisms involved are currently unclear. To examine this issue, we constructed models of rapid eye movement sleep deprivation (RSD) and POCD after sevoflurane inhalation, to evaluate the circadian mechanisms underlying preoperative sleep deprivation-induced POCD after sevoflurane inhalation. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.01.038DOI Listing
February 2019

Anxiogenic-like behavior and deficient attention/working memory in rats expressing the human DISC1 gene.

Pharmacol Biochem Behav 2019 Feb 16. Epub 2019 Feb 16.

Center for Behavioral Neuroscience, Institute of Experimental Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Electronic address:

In humans, mutations in the Disrupted-in-schizophrenia 1 (DISC1) gene have been related to psychiatric disorders, including symptoms of abnormal cognitive and emotional behaviors. In our previous studies, overexpression of the human DISC1 gene in rats resulted in schizophrenia-like phenotypes showing deficits in motor learning, impaired cognitive function and dysfunctions of the dopamine system. Here we asked, whether the DISC1 overexpression affects locomotor activity in the open field (OF), anxiety in the elevated plus-maze (EPM), depression-related behavior in the forced swim test (FST), and attention-like/short-term working-memory in the spontaneous alternation behavior (SAB) in the T-maze in transgenic DISC1 (tgDISC1) rats and littermate controls (WT). Read More

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http://dx.doi.org/10.1016/j.pbb.2019.02.005DOI Listing
February 2019

Application of neurite orientation dispersion and density imaging to characterize brain microstructural abnormalities in type-2 diabetics with mild cognitive impairment.

J Magn Reson Imaging 2019 Feb 19. Epub 2019 Feb 19.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Diffusion-tensor-imaging (DTI) is sensitive in detecting white matter changes in type-2 diabetes mellitus (T2DM). However, DTI indices can be affected by either neurite density or spatial variation. A novel diffusion MRI technique, termed neurite orientation dispersion and density imaging (NODDI), can provide distinct indices of fiber density and dispersion. Read More

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http://dx.doi.org/10.1002/jmri.26687DOI Listing
February 2019

Misidentification subtype of Alzheimer's disease psychosis predicts a faster cognitive decline.

CPT Pharmacometrics Syst Pharmacol 2019 Feb 19. Epub 2019 Feb 19.

UMR 1137, IAME INSERM, University Paris, Paris, France.

The presence of psychosis is associated with more rapid decline in Alzheimer's disease (AD), but the impact of paranoid (persecutory delusions) and misidentification (misperceptions and/or hallucinations) subtypes of psychosis on the speed of decline in AD is still unclear. Here we analysed data on Alzheimer's Disease Neuroimaging Initiative (ADNI)2 participants with late mild cognitive impairment or AD and we described individual trajectories of Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) scores using a semi-mechanistic, logistic model, with a mixed effects based approach, which accounted for drop-out, and adjusted for baseline Mini Mental State Examination scores. The covariate model included psychosis subtypes, age, gender, education, medications and Apo-e ε4 genotype. Read More

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http://dx.doi.org/10.1002/psp4.12389DOI Listing
February 2019

B Vitamins and Ageing.

Subcell Biochem 2018 ;90:451-470

Institute for Health and Sport, Victoria University, Werribee, VIC, Australia.

Vitamin B contributes to the overall health and wellbeing, including that of energy metabolism, methylation, synthesis and DNA repair and proper immune function. Deficiency in B vitamins has been linked to neurocognitive disorders, mitochondrial dysfunction, immune dysfunction and inflammatory conditions. In ageing populations B vitamin deficiency has been linked to cardiovascular disorders, cognitive dysfunction, osteoporosis and methylation disorders and can increase the risk of developing degenerative diseases, particularly cardiovascular disease, cognitive diseases and osteoporosis. Read More

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http://dx.doi.org/10.1007/978-981-13-2835-0_15DOI Listing
January 2018

Multi-angles of smoking and mild cognitive impairment: is the association mediated by sleep duration?

Neurol Sci 2019 Feb 19. Epub 2019 Feb 19.

College of Nursing, Jilin University, 965 Xinjiang Road, Changchun, 130000, China.

Although the association between cigarette smoking and risk of mild cognitive impairment (MCI) is controversial, most recent studies have shown that this influence is negative. However, it is unknown how multiple factors of smoking affect MCI, and the mechanisms of different smoking factors are not yet clarified. This study will examine the impact of various angles of smoking on MCI and the potential mediating effects of sleep duration on smoking MCI association in the elderly. Read More

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http://dx.doi.org/10.1007/s10072-019-03750-5DOI Listing
February 2019

[Validation of the Montreal Cognitive Assessment (MoCA) as a screening tool for mild cognitive impairment in the population of Buenos Aires, Argentina].

Vertex 2018 Jul;XXIX(140):261-269

Servicio de Neurología del Hospital Italiano de Buenos Aires, Argentina.

Introduction: The Montreal Cognitive Assessment (MoCA) test is a brief tool for neuropsychological assessment.

Objective: to validate the MoCAin the population of Buenos Aires, Argentina, to allow for the use of the test for the detection of Mild Cognitive Impairment (MCI).

Methods: The sample consisted of 269 adults over 60 years old and of schooling of more than 6 years (healthy adults n = 115 and MCIn = 154). Read More

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Dietary Iron Deficiency Impaired Peripheral Immunity but Did Not Alter Brain Microglia in PRRSV-Infected Neonatal Piglets.

Front Immunol 2018 4;9:3150. Epub 2019 Feb 4.

Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.

During the postnatal period the developing brain is vulnerable to insults including nutrient insufficiency and infection that may lead to disrupted development and cognitive dysfunction. Since iron deficiency (ID) often presents with immunodeficiency, the objective of this study was to investigate peripheral viremia and inflammation as well as brain microglial phenotype and function when ID and respiratory infection occur simultaneously in a neonatal piglet model. On postnatal day 2 (PD 2) male and female piglets were assigned to one of four treatments and fed either control or ID milk replacer. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369153PMC
February 2019

Association between Poor Sleep Quality and Subsequent Peptic Ulcer Recurrence in Older Patients with Mild Cognitive Impairment: Examining the Role of Social Engagement.

Sci Rep 2019 Feb 18;9(1):2188. Epub 2019 Feb 18.

Shantou University Medical College, Shantou, China.

This study aims to examine whether perceived poor sleep quality predicts subsequent recurrence of peptic ulcer disease (PUD) in older patients with mild cognitive impairment following Helicobacter pylori eradication and to investigate whether social engagement status alters this association. Of 1,689 older patients with H. pylori-infected PUD recruited from eight Grade-A hospitals in the People's Republic of China between 2011 and 2014, H. Read More

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http://dx.doi.org/10.1038/s41598-019-38715-3DOI Listing
February 2019

[Cerebral metabolism in patients with cognitive disorders: a combined MRS and PET study].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1):51-58

N. Bekhtereva Institute of the Human Brain, Russian Academy of Sciences, St.-Petersburg, Russia.

Aim: Magnetic resonance spectroscopy (MRS) allows studying the content of many metabolites in neural tissue in vivo. There are numerous studies devoted to the MRS data analysis in Alzheimer's disease (AD), but their results are contradictory. Thus, it is rational to compare the data obtained with MRS and positron emission tomography (PET) with fluorodeoxyglucose (FDG), which allows evaluating the brain functional state. Read More

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http://dx.doi.org/10.17116/jnevro201911901151DOI Listing
January 2019

[Clinical manifestations of burnout].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1):14-16

N. Bekhtereva Institute of the Human Brain Russian Academy of Sciences, St.-Petersburg, Russia.

Aim: To study clinical manifestations of burnout.

Material And Methods: The study included 131 patients (38 men and 93 women) aged from 25 to 45 years. The control group consisted of 106 age-matched healthy people. Read More

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http://dx.doi.org/10.17116/jnevro201911901114DOI Listing
January 2019

Beyond episodic memory: Semantic processing as independent predictor of hippocampal/perirhinal volume in aging and mild cognitive impairment due to Alzheimer's disease.

Neuropsychology 2019 Feb 18. Epub 2019 Feb 18.

Department of Neuroscience, University of Sheffield.

Objective: Given that lexical-semantic decline precedes episodic memory deficits in the Alzheimer's disease (AD) timeline, it is expected that performance on a lexical-semantic task would be associated with mediotemporal volumes independently of the association this region has with episodic memory in the early stage of AD.

Method: Fifty patients with mild cognitive impairment due to AD and 50 healthy adults completed tests of lexical-semantic skills (category fluency test), episodic memory for semantically relevant material (prose memory test), episodic memory for non semantically relevant material (Rey-Osterrieth Figure test), lexical-executive abilities (letter fluency test), and a neurostructural MRI. Hippocampal, perirhinal, entorhinal, temporopolar, and orbitofrontal volumes were extracted. Read More

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http://dx.doi.org/10.1037/neu0000534DOI Listing
February 2019

[Study on the relationship between age-related hearing loss and cognitive impairment].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;54(2):110-115

Department of Otorhinolaryngology, Peking University People's Hospital, Beijing 100044, China.

To investigate the correlation between age-related hearing loss and cognitive impairment. 201 elderly patients, who were admitted to the Department of Otorhinolaryngology of Peking University People's Hospital from March 1, 2017 to March 31, 2017, were evaluated with hearing screening and the Montreal Cognitive Assessment Scale. Among them, 101 were female and 100 were male, aged 60-90 years old. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.02.003DOI Listing
February 2019

Impaired behavioural flexibility related to white matter microgliosis in the TgAPP21 rat model of Alzheimer disease.

Brain Behav Immun 2019 Feb 15. Epub 2019 Feb 15.

Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, Western University, London ON, Canada; Department of Clinical Neurological Sciences, University Hospital, Western University, London, ON, Canada. Electronic address:

Executive dysfunction and white matter inflammation continue to be relatively understudied in rodent models of Alzheimer's disease (AD). Behavioural inflexibility is an important component of executive dysfunction that can be further categorized as perseverative or regressive, which respectively specify whether maladaptive persistence occurs early or late during a behavioural change. Previous studies of the TgAPP21 rat model of AD (expressing pathogenic hAPP) suggested a potentially spontaneous increase of regressive behavioral inflexibility. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.02.013DOI Listing
February 2019

[Fetal alcohol spectrum disorder. An underdiagnosed neuro-development disorder of uncertain prognosis].

Medicina (B Aires) 2019 ;79 Suppl 1:62-67

Departament de Psicologia i Psicobiologia Clínica, Universitat de Barcelona, Barcelona, España.

Prenatal exposure to alcohol is the cause of cognitive and behavioural disorders grouped under the term fetal alcohol spectrum disorders (FASD). The long-term evolution of subjects with FASD is often unfavourable, especially in social and academic fields. Executive dysfunction is a hallmark deficit for children with FASD with increased rates of externalizing behaviours, such as aggressiveness and frequently delinquency in adolescence and adulthood. Read More

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January 2019

Ghrelin-mediated improvements in the metabolic phenotype in the R6/2 mouse model of Huntington's disease.

J Neuroendocrinol 2019 Feb 18:e12699. Epub 2019 Feb 18.

Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.

Huntington's disease (HD) is a heritable neurodegenerative disorder, characterized by metabolic disturbances, along with cognitive and psychiatric impairments. Targeting metabolic HD dysfunction through maintenance of body weight and fat mass and restoration of peripheral energy metabolism can improve the progression of neurological symptoms. In this respect, we focused on the therapeutic potential of the orexigenic peptide hormone ghrelin, which plays an important role in promoting a positive energy balance. Read More

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http://dx.doi.org/10.1111/jne.12699DOI Listing
February 2019

Cognitive Fitness to Drive in Huntington's Disease: Assessing the Clinical Utility of DriveSafe DriveAware.

J Huntingtons Dis 2019 ;8(1):87-95

Calvary Health Care Bethlehem, Statewide Progressive Neurological Disease Service, Caulfield South, VIC, Australia.

Background: DriveSafe DriveAware (DSDA) has been validated as an off-road screening tool for predicting on-road driving performance in clinical populations, but its utility in people with Huntington's disease (HD) is unknown.

Objective: Our aim was to evaluate the utility of DSDA in people with HD by demonstrating sensitivity of DSDA scores to HD progression and exploring associations between DSDA performance and cognitive functions that are essential to driving and impaired in people with HD.

Methods: We administered the iPad application version of DSDA to 26 pre-symptomatic and symptomatic participants with HD. Read More

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http://dx.doi.org/10.3233/JHD-180323DOI Listing
January 2019

Contemporary Dance Practice Improves Motor Function and Body Representation in Huntington's Disease: A Pilot Study.

J Huntingtons Dis 2019 ;8(1):97-110

Brain and Spine Institute (ICM), Sorbonne Université, Pitié-Salpêtrière University Hospital, Paris, France.

Background: Physical exercise improves neurological conditions, but adherence is hard to establish. Dance might be a promising alternative; however, since patients with Huntington's disease (HD) suffer from rhythmic movement execution deficits, any metric dance practice must be avoided.

Objective: Here we asked, if contemporary dance, a lyrical dance form, practiced for two hours per week over five months, might improve motor function, neuropsychiatric variables, cognition and brain volume of HD patients. Read More

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http://dx.doi.org/10.3233/JHD-180315DOI Listing
January 2019

Treatment of Alzheimer's Disease: Trazodone, Sleep, Serotonin, Norepinephrine, and Future Directions.

J Alzheimers Dis 2019 ;67(3):923-930

War Related Illness and Injury Study Center, VA Palo Alto Health Care System and Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.

In this issue, an article by La et al. provides evidence that trazodone delayed cognitive decline in 25 participants with Alzheimer's disease (AD), mild cognitive impairment, or normal cognition. For participants considered to have AD pathology, trazodone non-users declined at a rate 2. Read More

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http://dx.doi.org/10.3233/JAD-181106DOI Listing
January 2019

The MemTrax Test Compared to the Montreal Cognitive Assessment Estimation of Mild Cognitive Impairment.

J Alzheimers Dis 2019 ;67(3):1045-1054

War Related Illness and Injury Study Center, VA Palo Alto HCS, Palo Alto, CA, USA.

Cognitive impairment is a leading cause of dysfunction in the elderly. When mild cognitive impairment (MCI) occurs in elderly, it is frequently a prodromal condition to dementia. The Montreal Cognitive Assessment (MoCA) is a commonly used tool to screen for MCI. Read More

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http://dx.doi.org/10.3233/JAD-181003DOI Listing
January 2019

Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling.

J Alzheimers Dis 2019 ;67(3):1089-1106

Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA.

Alzheimer's disease (AD) is characterized by the accumulation of neurotoxic amyloid-β (Aβ) peptides consisting of 39-43 amino acids, proteolytically derived fragments of the amyloid-β protein precursor (AβPP), and the accumulation of the hyperphosphorylated microtubule-associated protein tau. Inhibiting Aβ production may reduce neurodegeneration and cognitive dysfunction associated with AD. We have previously used an AβPP-firefly luciferase enzyme complementation assay to conduct a high throughput screen of a compound library for inhibitors of AβPP dimerization, and identified a compound that reduces Aβ levels. Read More

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http://dx.doi.org/10.3233/JAD-180923DOI Listing
January 2019

Connectivity Between Brain Networks Dynamically Reflects Cognitive Status of Parkinson's Disease: A Longitudinal Study.

J Alzheimers Dis 2019 ;67(3):971-984

Applied Neuroscience Research Group, Central European Institute of Technology, Masaryk University (CEITEC MU), Brno, Czech Republic.

Background: Cognitive impairment in Parkinson's disease (PD) is associated with altered connectivity of the resting state networks (RSNs). Longitudinal studies in well cognitively characterized PD subgroups are missing.

Objectives: To assess changes of the whole-brain connectivity and between-network connectivity (BNC) of large-scale functional networks related to cognition in well characterized PD patients using a longitudinal study design and various analytical methods. Read More

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http://dx.doi.org/10.3233/JAD-180834DOI Listing
January 2019

Midlife Long-Hour Working and Later-life Social Engagement Are Associated with Reduced Risks of Mild Cognitive Impairment among Community-Living Singapore Elderly.

J Alzheimers Dis 2019 ;67(3):1067-1077

The Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, School of Public Health, Guangxi Medical University, Nanning, Guangxi Province, China.

Mild cognitive impairment (MCI), as a transitional stage between normal aging and dementia, causes cognitive decline among one-fifth of elders aged 65 years and older. Health-related lifestyles (HRL) are generally regarded as modifiable influencing factors of cognitive decline. The present study investigated how HRLs at two different life stages (one at midlife and the other at later life) affect MCI occurrence among community-dwelling elders, as part of the Diet and Healthy Aging (DaHA) study in Singapore. Read More

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http://dx.doi.org/10.3233/JAD-180605DOI Listing
January 2019

Cognitive Improvement with Glutathione Supplement in Alzheimer's Disease: A Way Forward.

J Alzheimers Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway.

Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting millions of people worldwide. The actual cause of AD is still unknown. Oxidative stress is believed to be important player in AD. Read More

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http://dx.doi.org/10.3233/JAD-181054DOI Listing
February 2019

FTIR Spectroscopy of Cerebrospinal Fluid Reveals Variations in the Lipid: Protein Ratio at Different Stages of Alzheimer's Disease.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Faculty of Mathematics and Natural Sciences, Centre for Innovation and Transfer of Natural Sciences and Engineering Knowledge, University of Rzeszow, Poland.

Alzheimer's disease (AD) is a disease of advanced civilization and a common form of dementia in people over 65 years of age. We used Fourier transform infrared (FTIR) spectroscopy combined with principal component analysis (PCA) to determine changes in the quantity and quality of the cerebrospinal fluid from AD patients at three different stages of the disease (ADI, ADII, and ADIII), as well as from patients with mild cognitive impairment (MCI). Moreover, based on the FTIR spectra, we calculated the ratio of α-helix and β-sheet secondary protein structures as well as the lipid-protein balance as potential AD markers. Read More

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http://dx.doi.org/10.3233/JAD-181008DOI Listing
February 2019
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Elevation of pS262-Tau and Demethylated PP2A in Retina Occurs Earlier than in Hippocampus During Hyperhomocysteinemia.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Hubei Provincial Key Laboratory of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.

Hyperhomocysteinemia is an independent risk factor of Alzheimer's disease (AD), which is not diagnosed for many years before onset due to lack of peripherally detectable early biomarkers. Visual dysfunction is prevalent in AD patients and correlates with the severity of cognitive defects. Importantly, alterations in eyes can be non-invasively detected. Read More

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http://dx.doi.org/10.3233/JAD-180978DOI Listing
February 2019

The Influence of BDNF Val66Met Polymorphism on Cognition, Cerebrospinal Fluid, and Neuroimaging Markers in Non-Demented Elderly.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Background: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism emerged as a risk factor for Alzheimer's disease (AD). However, little was known about its effects on the process of potential AD.

Objective: To explore the effects of the Val66Met polymorphism on cognition, cerebrospinal fluid (CSF), and neuroimaging markers in non-demented elderly individuals. Read More

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http://dx.doi.org/10.3233/JAD-180971DOI Listing
February 2019

The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

We examined the cross-sectional association between mushroom intake and mild cognitive impairment (MCI) using data from 663 participants aged 60 and above from the Diet and Healthy Aging (DaHA) study in Singapore. Compared with participants who consumed mushrooms less than once per week, participants who consumed mushrooms >2 portions per week had reduced odds of having MCI (odds ratio = 0.43, 95% CI 0. Read More

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http://dx.doi.org/10.3233/JAD-180959DOI Listing
February 2019

Early-Stage Alzheimer's Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI, USA.

Background: Brain insulin resistance is a well-recognized abnormality in Alzheimer's disease (AD) and the likely mediator of impaired glucose utilization that emerges early and progresses with disease severity. Moreover, the rates of mild cognitive impairment (MCI) or AD are significantly greater in people with diabetes mellitus or obesity.

Objective: This study was designed to determine whether systemic and central nervous system (CNS) insulin resistant disease states emerge together and thus may be integrally related. Read More

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http://dx.doi.org/10.3233/JAD-180906DOI Listing
February 2019

Identification of a Simple and Novel Cut-Point Based Cerebrospinal Fluid and MRI Signature for Predicting Alzheimer's Disease Progression that Reinforces the 2018 NIA-AA Research Framework.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.

The 2018 NIA-AA research framework proposes a classification system with Amyloid-β deposition, pathologic Tau, and neurodegeneration (ATN) for diagnosis and staging of Alzheimer's disease (AD). Data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database can be utilized to identify diagnostic signatures for predicting AD progression, and to determine the utility of this NIA-AA research framework. Profiles of 320 peptides from baseline cerebrospinal fluid (CSF) samples of 287 normal, mild cognitive impairment (MCI), and AD subjects followed over a 3-10-year period were measured via multiple reaction monitoring mass spectrometry. Read More

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http://dx.doi.org/10.3233/JAD-180905DOI Listing
February 2019

Smart Home Technology: A New Approach for Performance Measurements of Activities of Daily Living and Prediction of Mild Cognitive Impairment in Older Adults.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Research Center of Institut universitaire de gériatrie de Montréal, Montreal, Canada.

Background: Functional assessment is of paramount importance when mild cognitive impairment is suspected, but common assessment tools such as questionnaires lack sensitivity. An alternative and innovative approach consists in using sensor technology in smart apartments during scenario-based assessments of instrumental activities of daily living (IADL). However, studies that investigate this approach are scarce and the technology used is not always transposable in healthcare settings. Read More

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http://dx.doi.org/10.3233/JAD-180652DOI Listing
February 2019

The role of mitochondrial defects and oxidative stress in Alzheimer's disease.

J Drug Target 2019 Feb 18:1-32. Epub 2019 Feb 18.

b King Fahd Medical Research Center, King Abdulaziz University , Jeddah , 21589 , Saudi Arabia.

Alzheimer's disease (AD) is a complex, progressive, irreversible neurodegenerative disorder. Recent reports suggest that it affects more than 36 million people worldwide and accounts 60-80% of all cases of dementia. It is characterized by aberrations of multiple interactive systems and pathways, which ultimately lead to memory loss and cognitive dysfunction. Read More

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http://dx.doi.org/10.1080/1061186X.2019.1584808DOI Listing
February 2019

AMPKα1 overexpression improves postoperative cognitive dysfunction in aged rats through AMPK-Sirt1 and autophagy signaling.

J Cell Biochem 2019 Feb 18. Epub 2019 Feb 18.

Department of Anesthesiology, Gansu Provincial Hospital, Lanzhou, Gansu, China.

Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients who undergo surgery involving anesthesia. Its underlying mechanisms remain unclear. Autophagy plays an important role in the damage and repair of the nervous system and is associated with the development of POCD. Read More

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http://dx.doi.org/10.1002/jcb.28443DOI Listing
February 2019

Chemotherapy-related cognitive dysfunction and effects on quality of life in gynecologic cancer patients.

Expert Rev Qual Life Cancer Care 2018 26;3(1):19-26. Epub 2018 Feb 26.

Department of Neurology, Department of Neurological Surgery, and Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA.

Introduction: chemotherapy-related cognitive dysfunction (CRCD) is a growing problem due to rising cancer rates and increasing numbers of cancer survivors. upwards of 70% of ovarian cancer patients report cognitive-changes following treatment for their cancer.

Areas Covered: the underlying mechanisms of CRCD are a subject of active research and debate. Read More

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http://dx.doi.org/10.1080/23809000.2018.1443811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377208PMC
February 2018

Two eARCHT3.0 Lines for Optogenetic Silencing of Dopaminergic and Serotonergic Neurons.

Front Neural Circuits 2019 1;13. Epub 2019 Feb 1.

McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, United States.

Dopaminergic and serotonergic neurons modulate and control processes ranging from reward signaling to regulation of motor outputs. Further, dysfunction of these neurons is involved in both degenerative and psychiatric disorders. Elucidating the roles of these neurons has been greatly facilitated by bacterial artificial chromosome (BAC) transgenic mouse lines expressing channelrhodopsin to readily enable cell-type specific activation. Read More

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http://dx.doi.org/10.3389/fncir.2019.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367884PMC
February 2019

Sevoflurane anesthesia impairs metabotropic glutamate receptor-dependent long-term depression and cognitive functions in senile mice.

Geriatr Gerontol Int 2019 Feb 17. Epub 2019 Feb 17.

Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang, China.

Aim: Postoperative cognitive dysfunction is often observed in older patients. Previous reports described the link between postoperative cognitive dysfunction and general anesthetics, such as sevoflurane, but the exact mechanism remains unclear. We therefore sought to characterize the effects of sevoflurane on hippocampal-dependent cognitive functions, as well as hippocampal plasticity, and to delineate the underlying mechanisms. Read More

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http://dx.doi.org/10.1111/ggi.13619DOI Listing
February 2019

Improvement in patient-reported sleep in type 2 diabetes and prediabetes participants receiving a continuous care intervention with nutritional ketosis.

Sleep Med 2019 Jan 3;55:92-99. Epub 2019 Jan 3.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address:

Objective: Sleep disruption is frequently associated with type 2 diabetes (T2D) and hyperglycemia. We recently reported the effectiveness of a continuous care intervention (CCI) emphasizing nutritional ketosis for improving HbA1c, body weight and cardiovascular risk factors in T2D patients. The present study assessed the effect of this CCI approach on sleep quality using a subjective patient-reported sleep questionnaire. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.12.014DOI Listing
January 2019

Structural brain network measures are superior to vascular burden scores in predicting early cognitive impairment in post stroke patients with small vessel disease.

Neuroimage Clin 2019 Feb 5;22:101712. Epub 2019 Feb 5.

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.

Objectives: In this cross-sectional study, we aimed to explore the mechanisms of early cognitive impairment in a post stroke non-dementia cerebral small vessel disease (SVD) cohort by comparing the SVD score with the structural brain network measures.

Method: 127 SVD patients were recruited consecutively from a stroke clinic, comprising 76 individuals with mild cognitive impairment (MCI) and 51 with no cognitive impairment (NCI). Detailed neuropsychological assessments and multimodal MRI were performed. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101712DOI Listing
February 2019

HSF1/HSP pathway in the hippocampus is involved in SIRT1-mediated caloric restriction-induced neuroprotection after surgery in aged mice.

Exp Gerontol 2019 Feb 14. Epub 2019 Feb 14.

Department of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address:

Postoperative cognitive dysfunction is common in the elderly. Endoplasmic reticulum stress (ER-stress) increases neuronal apoptosis after surgery, and chaperone molecules, such as heat shock proteins (HSPs), help reduce unfolded protein reactions, thereby promoting protein homeostasis. Mammal sirtuin1 (SIRT1)-mediated deacetylation of heat shock factor 1 (HSF1) upregulates HSF1 binding to the HSP70 promoter. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.011DOI Listing
February 2019

Deficiency of microglia and TNFα in the mPFC-mediated cognitive inflexibility induced by social stress during adolescence.

Brain Behav Immun 2019 Feb 14. Epub 2019 Feb 14.

CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. Electronic address:

The crucial roles played by the microglia and their release of cytokines in the regulation of brain maturation are increasingly being recognized. Adolescence is a unique period characterized by continued brain maturation, especially in the area of the prefrontal cortex. Our previous studies showed that adolescent social stress (ASS) induced impairment of extradimensional set-shifting (EDS), a core component of cognitive flexibility mediated by the medial prefrontal cortex (mPFC) in adult mice. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.02.010DOI Listing
February 2019

Functional connectivity associated with tau levels in ageing, Alzheimer's, and small vessel disease.

Brain 2019 Feb 15. Epub 2019 Feb 15.

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Feodor-Lynen Straße 17, Munich, Germany.

In Alzheimer's disease, tau pathology spreads hierarchically from the inferior temporal lobe throughout the cortex, ensuing cognitive decline and dementia. Similarly, circumscribed patterns of pathological tau have been observed in normal ageing and small vessel disease, suggesting a spatially ordered distribution of tau pathology across normal ageing and different diseases. In vitro findings suggest that pathological tau may spread 'prion-like' across neuronal connections in an activity-dependent manner. Read More

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http://dx.doi.org/10.1093/brain/awz026DOI Listing
February 2019

VisMET: a passive, efficient, and sensitive assessment of visuospatial memory in healthy aging, mild cognitive impairment, and Alzheimer's disease.

Learn Mem 2019 Mar 15;26(3):93-100. Epub 2019 Feb 15.

Department of Neurology, Emory University, Atlanta, Georgia 30312, USA.

The entorhinal-hippocampal circuit is one of the earliest sites of cortical pathology in Alzheimer's disease (AD). Visuospatial memory paradigms that are mediated by the entorhinal-hippocampal circuit may offer a means to detect memory impairment during the early stages of AD. In this study, we developed a 4-min visuospatial memory paradigm called VisMET (Visuospatial Memory Eye-Tracking Task) that passively assesses memory using eye movements rather than explicit memory judgements. Read More

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http://dx.doi.org/10.1101/lm.048124.118DOI Listing

Potential for Long-Term Benefit of Cognitive Behavioral Therapy as an Adjunct Treatment for Men with Erectile Dysfunction.

J Sex Med 2019 Feb;16(2):300-306

Department of Psychology, Valparaiso University, Valparaiso, IN, USA. Electronic address:

Introduction: Psychosexual counseling may enhance sexual performance outcomes in men with erectile dysfunction (ED) treated with a phosphodiesterase type 5 (PDE5) inhibitor.

Aim: To determine the potential long-term effects of cognitive behavioral therapy (CBT) on Pakistani men with ED who had undergone treatment with a PDE5 inhibitor (PDE5i).

Methods: In a 15-18-month follow-up, we reassessed a subsample of 20 men who had been treated with either PDE5is (monotherapy group) or CBT + PDE5i (combined group) on 2 dimensions: sexual functioning and mental health functioning. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.12.014DOI Listing
February 2019

Latent ERP components of cognitive dysfunctions in ADHD and schizophrenia.

Clin Neurophysiol 2019 Feb 10;130(4):445-453. Epub 2019 Feb 10.

Brain and Trauma Foundation, Grison, and Praxis für Kind, Organisation und Entwicklung, Chur, Switzerland.

Objective: The main goal was to assess common and specific deficits of cognitive control in (Attention Deficit Hyperactivity Disorder) ADHD and schizophrenia (SZ) using event-related potentials (ERPs).

Method: Behavioral and EEG data in cued GO/NOGO task were recorded in 132 healthy controls (HC) and age, gender and education matched 63 ADHD adults, and 68 SZ patients.

Results: N2d wave in NOGO-GO contrast of ERPs did not differ between the groups while the P3d wave discriminated SZ group from two other groups. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.015DOI Listing
February 2019

Extrinsic and default mode networks in psychiatric conditions: Relationship to excitatory-inhibitory transmitter balance and early trauma.

Neurosci Biobehav Rev 2019 Feb 12;99:90-100. Epub 2019 Feb 12.

Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway; Department of Radiology, Haukeland University Hospital, Bergen, Norway.

Over the last three decades there has been an accumulation of Magnetic Resonance Imaging (MRI) studies reporting that aberrant functional networks may underlie cognitive deficits and other symptoms across a range of psychiatric diagnoses. The use of pharmacological MRI and H-Magnetic Resonance Spectroscopy (H-MRS) has allowed researchers to investigate how changes in network dynamics are related to perturbed excitatory and inhibitory neurotransmission in individuals with psychiatric conditions. More recently, changes in functional network dynamics and excitatory/inhibitory (E/I) neurotransmission have been linked to early childhood trauma, a major antecedents for psychiatric illness in adulthood. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2019.02.004DOI Listing
February 2019

Chronic mild hypoxia promotes hippocampal neurogenesis involving Notch1 signaling in epileptic rats.

Brain Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurology, Key Laboratory of Neurology of Hebei Province, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, People's Republic of China. Electronic address:

Cognitive impairment is one of the most common and disabling co-morbidities of epilepsy. It is therefore imperative to find novel treatment approaches to rescue cognitive function among epilepsy patients. Adult neurogenesis is strongly implicated in cognitive function, and mild hypoxia is known to promote the proliferation and differentiation of both embryonic and adult neural stem cells (NSCs). Read More

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http://dx.doi.org/10.1016/j.brainres.2019.02.011DOI Listing
February 2019