29,371 results match your criteria Migraine Variants


Asthma phenotypes and associated comorbidities in a large cohort of adolescents in Israel.

J Asthma 2019 Apr 24:1-14. Epub 2019 Apr 24.

a Medical Corps, IDF , Israel.

Objectives: Asthma is a multifactorial, heterogeneous, complex and common chronic respiratory disease driven by diverse mechanisms. Although asthma presents various clinical forms with different levels of severity, it is unclear whether asthma severities are a consequence of disease management or varied etiologies. We sought to investigate this question. Read More

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http://dx.doi.org/10.1080/02770903.2019.1604743DOI Listing

CALCA and TRPV1 genes polymorphisms are related to a good outcome in female chronic migraine patients treated with OnabotulinumtoxinA.

J Headache Pain 2019 Apr 23;20(1):39. Epub 2019 Apr 23.

Headache Unit, Neurology Department, Hospital Clínico Universitario de Valladolid, Avda. Ramón y Cajal 3, 47005, Valladolid, Spain.

Background: Some variables have been proposed as predictors of efficacy of OnabotulinumtoxinA in chronic migraine patients, but data available are inconclusive. We aimed to analyse the influence of single nucleotide polymorphisms in the response to OnabotulinumtoxinA.

Methods: We included 156 female patients treated with OnabotulinumtoxinA accordingly to PREEMPT paradigm in three headache units. Read More

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http://dx.doi.org/10.1186/s10194-019-0989-9DOI Listing

Secondary Headaches During Pregnancy: When to Worry.

Curr Neurol Neurosci Rep 2019 Apr 22;19(6):27. Epub 2019 Apr 22.

Women's College Hospital Centre for Headache, Division of Neurology, University of Toronto, 76 Grenville St., Toronto, Ontario, M5S 1B2, Canada.

Purpose Of Review: Headaches in pregnancy are a frequent cause of worry for both patients and healthcare providers. Physiological changes during this period increase the risk of a number of secondary headache disorders, and often also have an impact on primary headache disorders. This article reviews recent research into distinguishing worrisome vs non-worrisome headache presentations during pregnancy. Read More

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http://dx.doi.org/10.1007/s11910-019-0944-9DOI Listing

Therapeutic novelties in migraine: new drugs, new hope?

J Headache Pain 2019 Apr 17;20(1):37. Epub 2019 Apr 17.

Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Background: In the past decade, migraine research has identified novel drug targets. In this review, we discuss recent data on emerging anti-migraine therapies.

Main Body: The development of ditans, gepants and anti-calcitonin gene-related peptide monoclonal antibodies for the treatment of migraine is one of the greatest advances in the migraine field. Read More

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https://thejournalofheadacheandpain.biomedcentral.com/articl
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http://dx.doi.org/10.1186/s10194-019-0974-3DOI Listing
April 2019
2 Reads

Migraine in patients with fibromyalgia and outcomes of greater occipital nerve blockage.

Clin Neurol Neurosurg 2019 Apr 9;181:54-57. Epub 2019 Apr 9.

Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Ankara, Turkey.

Objectives: The aim of this study is to evaluate the efficacy of greater occipital nerve (GON) blockage in patients with migraine and fibromyalgia (FM) comorbidity.

Patients And Method: 20 patients who were diagnosed as FM according to 2010 American College of Rheumatology (ACR) diagnostic criteria and migraine according to International Classification of Headache Disorers II criteria and did not recieve any medication or GON block for both disorders were included for the study. GON blocks were repeated every week in the first month and repeated montly for the following 2 months. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467193009
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http://dx.doi.org/10.1016/j.clineuro.2019.04.004DOI Listing
April 2019
2 Reads

PACAP-38 and PACAP(6-38) Degranulate Rat Meningeal Mast Cells the Orphan MrgB-Receptor.

Front Cell Neurosci 2019 28;13:114. Epub 2019 Mar 28.

Glostrup Research Institute, Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Copenhagen, Denmark.

Infusion of pituitary adenylate cyclase activating peptide-38 (PACAP-38) provokes migraine attacks in migraineurs and headache in non-migraineurs. Adverse events like long-lasting flushing and heat sensation can be terminated with oral antihistamine treatment, indicating the involvement of mast cell activation after PACAP-infusion. Degranulation of rat peritoneal mast cells was provoked by several isoforms of PACAP previously unknown receptor pharmacology. Read More

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http://dx.doi.org/10.3389/fncel.2019.00114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447718PMC
March 2019
4 Reads

Cyclic vomiting syndrome and benign paroxysmal torticollis are associated with a high risk of developing primary headache: A longitudinal study.

Cephalalgia 2019 Apr 13:333102419844542. Epub 2019 Apr 13.

1 Headache Center, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Background And Aim: Episodic syndromes that may be associated with migraine are a group of disorders affecting patients with migraine or with an increased risk of presenting it, and likely represent an early life expression of migraine. Cyclic vomiting syndrome and benign paroxysmal torticollis are well characterized and represent a frequent cause of request for specialist consultations. The aim of this study is to longitudinally assess the rate of headache in patients presenting with cyclic vomiting syndrome and benign paroxysmal torticollis during infancy, and to define the main clinical features of the disorder. Read More

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http://dx.doi.org/10.1177/0333102419844542DOI Listing
April 2019
2 Reads

Headaches and sleep problems in US adolescents: Findings from the National Comorbidity Survey - Adolescent Supplement (NCS-A).

Cephalalgia 2019 Apr 13:333102419835466. Epub 2019 Apr 13.

1 Genetic Epidemiology Branch, National Institute of Mental Health, Bethesda, MD, USA.

Background: There is limited research on the association of sleep problems with International Classification of Headache Disorders (ICHD-II)-defined headache subtypes in youth, particularly from community-based samples. This cross-sectional study examines the associations of sleep patterns, symptoms and disorders with specific headache subtypes among adolescents from the general population of the United States.

Methods: The sample includes 10,123 adolescents in the National Comorbidity Survey - Adolescent Supplement, a face-to-face survey of adolescents aged 13-18 years in the continental USA. Read More

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http://dx.doi.org/10.1177/0333102419835466DOI Listing
April 2019
2 Reads

The Association of Manual Muscle Tests and Treatment Outcomes With Headache and Cranial Dysfunctions: A Retrospective Case Series Report.

Altern Ther Health Med 2018 Nov;24(6):8-21

Background: This study examine whether there is an interrelationship between cranio-sacral dysfunctions and the muscle inhibitions found in the muscles attaching to the skull in patients with headaches.

Primary Study Objective: To present a retrospective case series report assessing the prevalence of positive manual muscle tests (MMTs) in the assessment and management of adults with headache and cervico-cranial dysfunctions and to present patient outcomes pre- and posttreatment.

Methods/design: Fifty-two patient files with headache (HA) (48 females, 4 males) were retrospectively examined. Read More

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November 2018

Migraine is not the most common comorbidity in hidradenitis suppurativa patients.

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Department of dermatology, allergology and venereology, Helsinki University Central Hospital, Helsinki, Finland.

Migraine is the most common primary headache syndrome worldwide, affecting approximately 12% of the Caucasian population [1]. Migraine has been associated with various cardiovascular [2] and psychiatric co-morbidities [3], more recently inflammatory disorders such as psoriasis [4] and inflammatory bowel disease [5]. As hidradenitis suppurativa (HS) shares common comorbidity risks, we sought to investigate the possible link between migraine and HS. Read More

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http://dx.doi.org/10.1111/jdv.15625DOI Listing
April 2019
1 Read

The effects of cerebral curvature on cortical spreading depression.

J Theor Biol 2019 Apr 9;472:11-26. Epub 2019 Apr 9.

Department of Mechanical Engineering, University of Canterbury, New Zealand.

Neuronal activity evokes a localised increase in cerebral blood flow through neurovascular coupling (NVC), a communication system between a group of cells known as a neurovascular unit (NVU). Dysfunctional NVC can lead to pathologies such as cortical spreading depression (CSD), characterised by a slowly propagating wave of neuronal depolarisation and high extracellular potassium (K) levels. CSD is associated with several neurological disorders such as migraine, stroke, and traumatic brain injury. Read More

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http://dx.doi.org/10.1016/j.jtbi.2019.04.006DOI Listing
April 2019
4 Reads

Somatic comorbidity in Polish patients with epilepsy.

Pol Arch Intern Med 2019 Apr 12. Epub 2019 Apr 12.

INTRODUCTION A range of somatic and psychiatric disorders occurs frequently in patients with epilepsy (PWE), which adds to the burden of epilepsy. OBJECTIVES To estimate the prevalence and risk factors of somatic comorbidities and  analyze the extent of somatic co-medication in adult PWE. PATIENTS AND METHODS This study involved PWE treated in university epilepsy clinic. Read More

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http://dx.doi.org/10.20452/pamw.14794DOI Listing
April 2019
1 Read

Vestibular migraine treatment and prevention.

Authors:
A Lapira

HNO 2019 Apr 8. Epub 2019 Apr 8.

St James & Capua Hospitals, George Borg Olivier St, SLM 1807, Sliema, Malta.

Vestibular migraine probably represents the second most common cause of vertigo after benign positional vertigo, by far exceeding Ménière disease. There are still relatively few published reports on vestibular migraine management, despite its enormous importance in daily practice. In 2003 the first clinical definition of vestibular migraine was proposed. Read More

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http://link.springer.com/10.1007/s00106-019-0661-3
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http://dx.doi.org/10.1007/s00106-019-0661-3DOI Listing
April 2019
6 Reads

Bidirectional association between migraine and fibromyalgia: retrospective cohort analyses of two populations.

BMJ Open 2019 Apr 8;9(4):e026581. Epub 2019 Apr 8.

School of Medicine, China Medical University, Taichung, Taiwan.

Objective: Fibromyalgia (FM) and migraine are common pain disorders that tend to coexist. This study determined whether these two conditions exhibited any mutual influences.

Setting: Cohort study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026581DOI Listing

Primary headaches during lifespan.

J Headache Pain 2019 Apr 8;20(1):35. Epub 2019 Apr 8.

Headache Research, Wolfson CARD, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Primary headaches are one of the most prevalent neurological disorders and can occur during a wide range of lifespan. Primary headaches, especially migraine, are cyclic disorders with a complex sequence of symptoms within every headache attack. There is no systematic review of whether these symptoms changes during lifespan. Read More

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http://dx.doi.org/10.1186/s10194-019-0985-0DOI Listing
April 2019
3 Reads

Migraine and episodic Vertigo: a cohort survey study of their relationship.

J Headache Pain 2019 Apr 8;20(1):33. Epub 2019 Apr 8.

Headache Medical Centre, Linz, Ordensklinikum Linz Barmherzige Schwestern, 4020, Linz, Austria.

Background And Aim: Migraine headache and vestibular-type vertigo co-occur in the general population about three times more often than expected by chance. Attacks of episodic vertigo (eV) are currently not recognized as migraine equivalents or variants in the International Classification of Headache Disorders, 3rd edition (ICHD III). No strong data exist about the prevalence of eV during the phases of a migraine attack. Read More

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http://dx.doi.org/10.1186/s10194-019-0991-2DOI Listing

Prevalence of headache attributed to aeroplane travel in headache outpatient populations: An Italian multicentric survey.

Cephalalgia 2019 Apr 8:333102419843676. Epub 2019 Apr 8.

2 Headache Centre, Department of Neurosciences, University of Padua, Padua, Italy.

Background: To assess the prevalence of headache attributed to aeroplane travel (AH) in patients referred to Italian Headache Centres.

Material And Method: 869 consecutive patients visiting six Italian headache centres during a 6 month-period (October 2013 to March 2014) were enrolled in the survey. Among them, 136 (15. Read More

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http://dx.doi.org/10.1177/0333102419843676DOI Listing
April 2019
2 Reads

Did Going North Give Us Migraine? An Evolutionary Approach on Understanding Latitudinal Differences in Migraine Epidemiology.

Headache 2019 Apr 7;59(4):632-634. Epub 2019 Apr 7.

Department of Zoology, University of Cambridge, Cambridge, United Kingdom.

This commentary discusses a recent publication by evolutionary biologists with strong implications for migraine experts. The Authors showed that a gene polymorphism associated with migraine gave our ancestors an evolutionary advantage when colonizing northern, and thus colder, territories. They then highlight that the prevalence of migraine may differ among countries because of climatic adaptation. Read More

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http://dx.doi.org/10.1111/head.13520DOI Listing

[Vomiting as a symptom of epilepsy. Panayitopoulos Syndrome - review of the literature and own experience].

Dev Period Med 2019 ;23(1):28-33

Klinika Pediatrii Alergologii i Gastroenterologii Collegium Medicum w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu, Polska.

Vomiting is a common sign of illness in the pediatric population. Its etiology is diversified, ranging from mild functional disorders to severe life-threatening systemic diseases. Vomiting most often occurs in the course of gastrointestinal tract diseases, however, it may also coexist with numerous other ailments located outside the GI tract. Read More

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January 2019
3 Reads

Acute ataxia in paediatric emergency departments: a multicentre Italian study.

Arch Dis Child 2019 Apr 4. Epub 2019 Apr 4.

Pediatric Emergency Department, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Objectives: To evaluate the causes and management of acute ataxia (AA) in the paediatric emergency setting and to identify clinical features predictive of an underlying clinically urgent neurological pathology (CUNP).

Study Design: This is a retrospective medical chart analysis of children (1-18 years) attending to 11 paediatric emergency departments (EDs) for AA in an 8-year period. A logistic regression model was applied to identify clinical risk factors for CUNP. Read More

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http://adc.bmj.com/lookup/doi/10.1136/archdischild-2018-3154
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http://dx.doi.org/10.1136/archdischild-2018-315487DOI Listing
April 2019
16 Reads

Global assessment of migraine severity measure: preliminary evidence of construct validity.

BMC Neurol 2019 Apr 4;19(1):53. Epub 2019 Apr 4.

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA.

Background: In persons with migraine, severity of migraine is an important determinant of several health outcomes (e.g., patient quality of life and health care resource utilization). Read More

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http://dx.doi.org/10.1186/s12883-019-1284-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448190PMC
April 2019
4 Reads

Special Considerations for the Pediatric Patient.

Adv Otorhinolaryngol 2019 15;82:134-142. Epub 2019 Jan 15.

Children frequently present with complaints of vertigo and/or disequilibrium. The etiology of such diagnoses include inner ear pathology, migraine and its variants, lesions of the central nervous system as well as mental health disorders, among others. The ability to reliably evaluate vestibular end-organ function is central to accurate diagnosis, however, examining children can be challenging. Read More

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http://dx.doi.org/10.1159/000490282DOI Listing
January 2019
5 Reads

Serotonin-estrogen interactions: What can we learn from pregnancy?

Biochimie 2019 Apr 1. Epub 2019 Apr 1.

INRS-Institut Armand-Frappier, 531, boulevard des Prairies, Laval, QC, H7V 1B7, Canada; Center for Interdisciplinary Research on Well-Being, Health, Society and Environment (Cinbiose), Université du Québec à Montréal, C.P.8888, succ. Centre-Ville, Montréal, QC, H3C 3P8, Canada. Electronic address:

We have reviewed the scientific literature related to four diseases in which to serotonin (5-HT) is involved in the etiology, herein named 5-HT-linked diseases, and whose prevalence is influenced by estrogenic status: depression, migraine, irritable bowel syndrome and eating disorders. These diseases all have in common a sex-dimorphic prevalence, with women more frequently affected than men. The co-occurrence between these 5-HT-linked diseases suggests that they have common physiopathological mechanisms. Read More

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http://dx.doi.org/10.1016/j.biochi.2019.03.023DOI Listing

Autonomic neurophysiologic implications of disorders comorbid with bladder pain syndrome vs myofascial pelvic pain.

Neurourol Urodyn 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Aims: The neuropathophysiology of a debilitating chronic urologic pain condition, bladder pain syndrome (BPS), remains unknown. Our recent data suggests withdrawal of cardiovagal modulation in subjects with BPS, in contrast to sympathetic nervous system dysfunction in another chronic pelvic pain syndrome, myofascial pelvic pain (MPP). We evaluated whether comorbid disorders differentially associated with BPS vs MPP shed additional light on these autonomic differences. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/nau.23995
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http://dx.doi.org/10.1002/nau.23995DOI Listing
April 2019
6 Reads

OnabotulinumtoxinA in Migraine and Other Headaches: Review and Update.

Curr Treat Options Neurol 2019 Apr 4;21(4):21. Epub 2019 Apr 4.

Department of Neurology, University of California, Davis, 4160, Y St., No. 3700, Sacramento, CA, 95817, USA.

Purpose Of The Review: The role of onabotulinumtoxinA in headache management was serendipitously found over a decade ago and approved for chronic migraine in 2010 based on pivotal studies. The purpose of this review is to highlight the impact on headache and other health parameters which is critically reviewed, as well as the putative mechanisms of action.

Recent Findings: OnabotulinumtoxinA is effective in migraine, not only headache frequency and pain intensity but also other health parameters including quality of life. Read More

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http://dx.doi.org/10.1007/s11940-019-0561-6DOI Listing
April 2019
1 Read

Increased risk of sleep apnoea among primary headache disorders: a nationwide population-based longitudinal study.

Postgrad Med J 2019 Feb 1;95(1120):72-77. Epub 2019 Apr 1.

Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

Background: Primary headache disorders (PHDs) are associated with sleep problems. It is suggested that headache and sleep disorder share anatomical and physiological characteristics. We hypothesised that patients with PHDs were exposed to a great risk for developing sleep apnoea (SA). Read More

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http://dx.doi.org/10.1136/postgradmedj-2018-136220DOI Listing
February 2019
2 Reads

Painful Temporomandibular Disorder is Associated with Migraine in Adolescents: a case-control study.

J Pain 2019 Mar 29. Epub 2019 Mar 29.

Department of Dental Materials and Prosthodontics, Araraquara School of Dentistry, Univ Estadual Paulista - UNESP, Araraquara, Brazil. Electronic address:

Some types of primary headaches and temporomandibular disorders (TMD) are comorbid in adults and highly prevalent in adolescents. Herein, we investigated the association of painful TMD with specific headache diagnoses (migraine, tension-type headache) and with headache frequency in adolescents. We also explored the association of headache diagnosis with the number of painful sites in the trigeminal area. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.03.010DOI Listing
March 2019
2 Reads

Antiepileptic Drug Treatment Patterns in Women of Childbearing Age With Epilepsy.

JAMA Neurol 2019 Apr 1. Epub 2019 Apr 1.

UCB Pharma, Raleigh, North Carolina.

Importance: Limited population-based data are available on antiepileptic drug (AED) treatment patterns in women of childbearing age with epilepsy; the current population risk is not clear.

Objectives: To examine the AED treatment patterns and identify differences in use of valproate sodium and topiramate by comorbidities among women of childbearing age with epilepsy.

Design, Setting, And Participants: A retrospective cohort study used a nationwide commercial database and supplemental Medicare as well as Medicaid insurance claims data to identify 46 767 women with epilepsy aged 15 to 44 years. Read More

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http://dx.doi.org/10.1001/jamaneurol.2019.0447DOI Listing
April 2019
2 Reads

An Approach to Identifying Headache Patients That Require Neuroimaging.

Front Public Health 2019 15;7:52. Epub 2019 Mar 15.

Department of Neurology, Woman's College Hospital, Toronto, ON, Canada.

Headache is one of the most common clinical scenarios faced by a neurologist or neurologist in training. However, the decision process on when to complete neuroimaging can be difficult in clinical practice. This article focuses on a well-organized and evidence-based approach to identify patients with headache that require neuroimaging and will lend confidence to the clinician faced with these scenarios in clinical practice. Read More

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http://dx.doi.org/10.3389/fpubh.2019.00052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428716PMC
March 2019
1 Read

Real-world insights on the management of migraine patients: an Italian nationwide study.

Curr Med Res Opin 2019 Mar 29. Epub 2019 Mar 29.

f TEVA Italia Srl , Assago , MI , Italy.

Objectives: Understanding migraine management using data from a sample of patients representative of the Italian general adult population.

Methods: Retrospective analysis on IQVIA Italian Longitudinal Patient Database. Two cohorts were created: a) triptans users' cohort included patients with triptans prescriptions between Nov-2015 and Oct-2016. Read More

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http://dx.doi.org/10.1080/03007995.2019.1602032DOI Listing

Headache Triggers as Surprise.

Headache 2019 Apr 28;59(4):495-508. Epub 2019 Mar 28.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Objectives: To examine the hypothesis that surprising experiences of headache triggers are associated with daily headache activity.

Background: Little is known about the specific environmental or behavioral interactions that might trigger a headache attack in a prone individual. We propose that headache trigger exposures can be usefully characterized, not only by their mechanisms of action, but also on the degree of "surprise" they present to the individual. Read More

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http://dx.doi.org/10.1111/head.13507DOI Listing

Genetics of cluster headache.

Cephalalgia 2019 Mar 27:333102418815503. Epub 2019 Mar 27.

1 Xenon Pharmaceuticals Inc, Burnaby, Canada.

Background: Cluster headache is the most severe primary headache disorder. A genetic basis has long been suggested by family and twin studies; however, little is understood about the genetic variants that contribute to cluster headache susceptibility.

Methods: We conducted a literature search of the MEDLINE database using the PubMed search engine to identify all human genetic studies for cluster headache. Read More

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http://dx.doi.org/10.1177/0333102418815503DOI Listing
March 2019
1 Read

Familial hemiplegic migraine in a child with seizure disorder: clinical history is the key to diagnosis.

BMJ Case Rep 2019 Mar 25;12(3). Epub 2019 Mar 25.

Department of Paediatrics, Manipal Melaka Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Headache is a common presenting complaint in the paediatric population, with often migraine being a clinical diagnosis. Hemiplegic migraine is characterised by aura, sudden onset weakness of one side of the body which usually recovers without any residual neurological deficit. We report a child with a history of seizure disorder, well controlled and off medication for 3 years, who presented with a headache, aura and transient hemiplegia. Read More

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http://dx.doi.org/10.1136/bcr-2018-228687DOI Listing
March 2019
1 Read

Cervical Muscular Endurance Performance in Women With and Without Migraine.

J Orthop Sports Phys Ther 2019 Mar 26:1-24. Epub 2019 Mar 26.

Department of Health Science, Ribeirão Preto Medical School - University of São Paulo, Ribeirão Preto-SP, Brazil.

Study Design: Cross-sectional, controlled laboratory study.

Background: Despite previous evidence, the association between migraines and cervical muscular performance is unclear.

Objective: To compare the differences in neck flexor and extensor muscle endurance between women with and without migraine. Read More

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http://dx.doi.org/10.2519/jospt.2019.8816DOI Listing
March 2019
1 Read

Histamine and migraine revisited: mechanisms and possible drug targets.

J Headache Pain 2019 Mar 25;20(1):30. Epub 2019 Mar 25.

Danish Headache Center and Department of Neurology N39, University of Copenhagen, Rigshospitalet Glostrup, DK-2600, Copenhagen, Denmark.

Objective: To review the existing literature on histamine and migraine with a focus on the molecule, its receptors, its use in inducing migraine, and antihistamines in the treatment of migraine.

Background: Histamine has been known to cause a vascular type headache for almost a hundred years. Research has focused on antihistamines as a possible treatment and histamine as a migraine provoking agent but there has been little interest in this field for the last 25 years. Read More

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https://thejournalofheadacheandpain.biomedcentral.com/articl
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http://dx.doi.org/10.1186/s10194-019-0984-1DOI Listing
March 2019
3 Reads

Sleep disorder-related headaches.

Neurol Sci 2019 Mar 25. Epub 2019 Mar 25.

School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy.

Migraine with and without aura, cluster headache, hypnic headache, and paroxysmal hemicranias are each reported as intrinsically related to sleep. Chronic migraine, chronic tension-type headache, and medication overuse headache may cause sleep disturbance. Otherwise, both headache and sleep disorder may be manifestations of a same systemic dysfunction. Read More

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http://dx.doi.org/10.1007/s10072-019-03837-zDOI Listing
March 2019
2 Reads

Migraine associated with gastrointestinal disorders: A pathophysiological explanation.

Med Hypotheses 2019 Apr 19;125:90-93. Epub 2019 Feb 19.

Department of Iranian Traditional Medicine, Faculty of Medicine, Shahed University, Tehran, Iran.

Background: Migraine is a highly prevalent, disabling, and costly disorder worldwide. From a long time ago, headaches have been known to be associated with gastrointestinal (GI) disorders. Headaches originating from gastric complaints were appreciated by Persian Medicine (PM) scholars. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.041DOI Listing

Negative Short-Term Outcome of Detoxification Therapy in Chronic Migraine With Medication Overuse Headache: Role for Early Life Traumatic Experiences and Recent Stressful Events.

Front Neurol 2019 7;10:173. Epub 2019 Mar 7.

Headache Science Centre, IRCCS Mondino Foundation, Pavia, Italy.

Early traumatic experiences and Stressful episodes appear to be associated to the development and perpetuation of chronic pain disorders and to dependence-related behaviors. The present study evaluated whether these factors can be predictors, together with psychiatric conditions, of the outcome of a detoxification treatment in patients suffering from chronic migraine and medication-overuse headache in a 2-month follow-up. Consecutive patients undergoing a detoxification program as therapy for treating chronic migraine and medication overuse headache at the Pavia Headache Center were analyzed. Read More

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http://dx.doi.org/10.3389/fneur.2019.00173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416203PMC
March 2019
3 Reads

A prospective study of headache and neuropeptides in patients with pituitary adenomas.

Cephalalgia 2019 Mar 21:333102419839963. Epub 2019 Mar 21.

1 Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: To evaluate clinical criteria for headache associated with pituitary adenoma (HaPA) in the International Classification of Headache Disorders (ICHD) 3rd edition version criteria and further determine whether elevations of plasma calcitonin gene-related peptide and pituitary adenylate cyclase-activating peptide 1-38 (PACAP1-38) concentration contribute to HaPA.

Methods: Demographic and clinical features of consecutive patients with pituitary adenoma were recorded. Plasma calcitonin gene-related peptide and PACAP1-38 concentrations in pituitary adenoma patients within 72 h pre- and post-operation were measured. Read More

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http://dx.doi.org/10.1177/0333102419839963DOI Listing

The association between migraine and restless legs syndrome: an updated systematic review and meta-analysis.

Sleep Med 2019 Feb 2;57:21-29. Epub 2019 Feb 2.

School of Medicine, Nankai University, Tianjin, 300071, China; Department of Neurology, Chinese PLA General Hospital, Beijing, 100853, China. Electronic address:

Objective: This study aims to gain further insight into the association between migraine and restless legs syndrome (RLS).

Methods: A literature search of PubMed, Embase, and Web of Science was performed for studies investigating the association between any migraine and RLS; a meta-analysis of eligible studies was conducted to determine a pooled effect estimate for the association.

Results: Fifteen studies were included in this meta-analysis. Read More

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http://dx.doi.org/10.1016/j.sleep.2019.01.027DOI Listing
February 2019
2 Reads

Leading symptoms in cerebrovascular diseases: what about headache?

Neurol Sci 2019 Mar 20. Epub 2019 Mar 20.

Department of Neuroscience, Neurology and Stroke Unit, ASST GOM Niguarda Cà Granda Hospital, Piazza Ospedale Maggiore 3, 20162, Milan, Italy.

Headache is a milestone in cerebrovascular disorders; indeed, it may represent the only symptom at onset or predominates over the other neurological features. Unfortunately, headache associated with cerebrovascular diseases lacks clear-cut characteristics as it may resemble a migraine attack, tension-type headache, or cluster headache; pain localization is also misleading along with drug (analgesic) response. However, in this review, we have analyzed and described the most common patterns of headache for different vascular disorders: it is known that headache due to subarachnoid aneurysmal hemorrhage presents peculiar characteristics (thunderclap, acute presentation, and high intensity), whereas in cerebral vasoconstriction syndrome, the short duration and the relapsing-remitting course of the thunderclap headache are key points for the diagnosis; in cervicocerebral artery, dissection pain is most commonly ipsilateral to the dissected vessel and is mainly perceived in the temporal area in case of carotid artery dissection and in the occipital area in case of vertebral artery dissection; in cerebral venous thrombosis, pain is often acute or subacute and severe; unfortunately, it may resemble a typical migraine attack or a tension-type episode; by the contrary, in primary angiitis of the central nervous system, pain is always subacute or chronic with mild-to-moderate intensity; finally, in brain arteriovenous shunts such as malformation or fistula, pain is more frequently a clue for disease complication such as hemorrhage from the malformation or thrombosis of the draining vein. Read More

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http://link.springer.com/10.1007/s10072-019-03793-8
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http://dx.doi.org/10.1007/s10072-019-03793-8DOI Listing
March 2019
4 Reads

Features of Primary Chronic Headache in Children and Adolescents and Validity of Ichd 3 Criteria.

Front Neurol 2019 15;10:92. Epub 2019 Feb 15.

Headache Center, Department of Neuroscience, Bambino Gesù Children Hospital, Rome, Italy.

Chronic headaches are not a rare condition in children and adolescents with negative effects on their quality of life. Our aims were to investigate the clinical features of chronic headache and usefulness of the International Classification of Headache Disorders 3rd edition (ICHD 3) criteria for the diagnosis in a cohort of pediatric patients. We retrospectively reviewed the charts of patients attending the Headache Center of Bambino Gesù Children and Insubria University Hospital during the 2010-2016 time interval. Read More

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http://dx.doi.org/10.3389/fneur.2019.00092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413701PMC
February 2019

Diagnosing allodynia requires the assessment of pain.

Pain 2019 04;160(4):985

Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1097/j.pain.0000000000001476DOI Listing

Occipital Neuralgia and Cervicogenic Headache: Diagnosis and Management.

Curr Neurol Neurosci Rep 2019 Mar 19;19(5):20. Epub 2019 Mar 19.

Women's College Hospital Centre for Headache, Division of Neurology, University of Toronto, Toronto, Canada.

Purpose Of Review: Occipital neuralgia (ON) and cervicogenic headache (CGH) are secondary headache disorders with occipital pain as a key feature. Due to significant phenotypic overlap, differentiating ON and CGH from primary headache disorders such as migraine or tension-type headache, or other secondary headache disorders, can be clinically challenging. This article reviews the anatomy, clinical features, unique diagnostic considerations, and management approaches relating to ON and CGH. Read More

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http://dx.doi.org/10.1007/s11910-019-0937-8DOI Listing
March 2019
2 Reads

Genome-wide association analysis reveals KCTD12 and miR-383-binding genes in the background of rumination.

Transl Psychiatry 2019 Mar 18;9(1):119. Epub 2019 Mar 18.

Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.

Ruminative response style is a passive and repetitive way of responding to stress, associated with several disorders. Although twin and candidate gene studies have proven the genetic underpinnings of rumination, no genome-wide association study (GWAS) has been conducted yet. We performed a GWAS on ruminative response style and its two subtypes, brooding and reflection, among 1758 European adults recruited in the general population of Budapest, Hungary, and Manchester, United Kingdom. Read More

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http://dx.doi.org/10.1038/s41398-019-0454-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423133PMC
March 2019
2 Reads

Comparison of two ultrasound-guided techniques for greater occipital nerve injections in chronic migraine: a double-blind, randomized, controlled trial.

Reg Anesth Pain Med 2019 May 18;44(5):595-603. Epub 2019 Mar 18.

Anesthesia, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada

Background And Objectives: Two ultrasound (US)-guided techniques for greater occipital nerve (GON) block have been described for the management of headache disorders: a "proximal or central" technique targeting the GON at the level of the second cervical vertebra and a "distal or peripheral" technique targeting the GON at the level of the superior nuchal line. In this multicenter, prospective, randomized control trial, we compared accuracy, effectiveness, and safety of these two techniques in patients with chronic migraines (CMs).

Methods: Forty patients with refractory CMs were randomized to receive either a proximal or distal US-guided GON block with bupivacaine and methylprednisolone acetate. Read More

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http://dx.doi.org/10.1136/rapm-2018-100306DOI Listing
May 2019
3 Reads
3.089 Impact Factor

Advance in genetics of migraine.

Curr Opin Neurol 2019 Mar 14. Epub 2019 Mar 14.

Department of Neurology.

Purpose Of Review: Migraine is a primary headache disorder and one of the most common and disabling neurological diseases worldwide. Genome-wide association studies have identified ≈40 genetic loci associated with migraine. How these and other genetic findings are used to expand our knowledge on the pathophysiological mechanism of common migraine and rare migraine variants will be discussed. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000687DOI Listing
March 2019
3 Reads

Migraine during pregnancy and in the puerperium.

Neurol Sci 2019 Mar 18. Epub 2019 Mar 18.

Women's Headache Center, Department of Surgical Sciences, University of Turin, Via Ventimiglia 3, 10126, Turin, Italy.

Pregnancy can be seen as a positive time for women migraineurs because the elevated estrogen and endogenous opioid levels raise the pain threshold and the stable hormone levels, which no longer fluctuate, eliminate a major trigger factor for the attacks. In a great majority of cases, indeed, migraine symptoms spontaneously improve throughout pregnancy. Generally, migraine without aura (MO) improves better than migraine with aura (MA), which can occur ex novo in pregnancy more frequently than MO. Read More

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http://dx.doi.org/10.1007/s10072-019-03792-9DOI Listing
March 2019
1 Read

Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Authors:

Lancet Neurol 2019 May 14;18(5):459-480. Epub 2019 Mar 14.

Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders.

Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. Read More

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http://dx.doi.org/10.1016/S1474-4422(18)30499-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459001PMC
May 2019
2 Reads
21.896 Impact Factor