34,729 results match your criteria Migraine Variants

Real-world effectiveness after initiating fremanezumab treatment in US patients with episodic and chronic migraine or difficult-to-treat migraine.

J Headache Pain 2022 May 16;23(1):56. Epub 2022 May 16.

Analysis Group, Boston, MA, USA.

Background: Fremanezumab, a fully humanized monoclonal antibody (mAb; IgG2Δa) that selectively targets calcitonin gene-related peptide (CGRP), is approved for the preventive treatment of migraine in adults. The efficacy and safety of fremanezumab for migraine prevention have been demonstrated in randomized, double-blind, placebo-controlled trials. Real-world effectiveness data are needed to complement clinical trial data. Read More

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Migraine-associated common genetic variants confer greater risk of posterior vs. anterior circulation ischemic stroke☆.

J Stroke Cerebrovasc Dis 2022 May 13;31(8):106546. Epub 2022 May 13.

Department of Neurology, Miller School of Medicine, University of Miami, The Evelyn F. McKnight Brain Institute, FL, USA.

Objective: To examine potential genetic relationships between migraine and the two distinct phenotypes posterior circulation ischemic stroke (PCiS) and anterior circulation ischemic stroke (ACiS), we generated migraine polygenic risk scores (PRSs) and compared these between PCiS and ACiS, and separately vs. non-stroke control subjects.

Methods: Acute ischemic stroke cases were classified as PCiS or ACiS based on lesion location on diffusion-weighted MRI. Read More

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Efficacy of Sumatriptan/Placebo versus Sumatriptan/Propofol Combination in Acute Migraine; a Randomized Clinical Trial.

Arch Acad Emerg Med 2022 14;10(1):e27. Epub 2022 Apr 14.

Emergency Department, Mehriz Fatemeh Zahra Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Introduction: Migraine headaches can cause severe pain for patients and lead them to multiple visits to the emergency department (ED). This study aimed to evaluate the efficacy of propofol + sumatriptan combination in comparison with sumatriptan alone in the management of acute migraine headaches.

Methods: This triple-blind clinical trial involved patients who referred to two emergency departments with acute migraine headaches. Read More

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Does fructose have a protective role on migraine?-experimental evidence in a rat model of metabolic syndrome under omega-3 supplementation.

Ann Transl Med 2022 Apr;10(8):435

PUCRS, Programa de Pós-Graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Porto Alegre, RS, Brasil.

Background: Migraine is a highly disabling disease, for which current therapies are limited to symptom alleviation. There is compelling evidence linking migraine with metabolic disorders, but the causal relationship is not clear. Omega-3 (n-3) fatty acids have anti-inflammatory properties, with clear benefits in metabolic disorders, but its effects on migraine remains to be tested. Read More

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Health-related quality of life and associated factors in Chinese menstrual migraine patients: a cross-sectional study.

BMC Womens Health 2022 May 15;22(1):177. Epub 2022 May 15.

Department of Psychiatry, The North Sichuan Medical College, Nanchong, Sichuan Province, China.

Background: Menstrual migraine is a particular form of migraine with a significant impact on the quality of life for women afflicted. Presently, no study has reported the quality of life in menstrual migraine patients. This work aims to assess the health-related quality of life and identify its associated factors among Chinese menstrual migraine patients. Read More

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The Association between Migraine and Fetal-Type Posterior Cerebral Artery in Patients with Ischemic Stroke.

Cerebrovasc Dis 2022 May 13:1-7. Epub 2022 May 13.

Department of Neurology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, China.

Objective: The aim of the study was to determine if migraine is associated with fetal-type posterior cerebral artery (PCA) in patients with ischemic stroke.

Method: In this cross-sectional study, patients with acute ischemic stroke were enrolled from two hospitals. The history of migraine headache was evaluated during a face-to-face interview. Read More

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Idiopathic combined retinal vessels occlusion in a pregnant woman: a case report.

J Med Case Rep 2022 May 15;16(1):191. Epub 2022 May 15.

Obstetrics and Gynecology Department, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Ocular vascular occlusion is an extremely rare event, especially in the young population. This diagnosis is always associated with active systemic diseases in young adults and needs thrombophilia workup. Nevertheless, we present the case of a pregnant woman suffering from idiopathic combined central retinal vein and cilioretinal artery occlusion. Read More

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Interplay of Oral, Mandibular, and Facial Disorders and Migraine.

Curr Pain Headache Rep 2022 May 14. Epub 2022 May 14.

Brotman Facial Pain Clinic, Department of Neural and Pain Sciences, University of Maryland, School of Dentistry, 650 W. Baltimore St. 8th Floor, Baltimore, MD, 21201, USA.

Purpose Of The Review: Migraine and other primary headache disorders can be localized in the face resembling facial or dental pain, indicating the influence of the trigeminovascular system in the structures innervated by the maxillary (V2) and mandibulary (V3) branches of the trigeminal nerve. Disorders of oral and craniofacial structures may influence primary headache disorders. In the current article, we review the potential links of this interplay. Read More

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The Therapeutic Role of Ketogenic Diet in Neurological Disorders.

Nutrients 2022 May 6;14(9). Epub 2022 May 6.

Chair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8b Street, 20-090 Lublin, Poland.

The ketogenic diet (KD) is a high-fat, low-carbohydrate and adequate-protein diet that has gained popularity in recent years in the context of neurological diseases (NDs). The complexity of the pathogenesis of these diseases means that effective forms of treatment are still lacking. Conventional therapy is often associated with increasing tolerance and/or drug resistance. Read More

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A Randomised, Double-Blind, Placebo-Controlled Crossover Trial of Resveratrol Supplementation for Prophylaxis of Hormonal Migraine.

Nutrients 2022 Apr 22;14(9). Epub 2022 Apr 22.

School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan 2308, Australia.

Resveratrol, a vasoactive phytoestrogen, has beneficial effects on cerebrovascular function. Previous research has shown that hormonal migraineurs have poorer cerebrovascular function than non-migraineur women. We aimed to investigate if resveratrol supplementation for three months could reduce the hormonal migraine burden index (HMBI: the number of days with menstrual migraine per month), reduce migraine-related disability and improve migraine-related quality of life. Read More

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Supplementation with SCFAs Re-Establishes Microbiota Composition and Attenuates Hyperalgesia and Pain in a Mouse Model of NTG-Induced Migraine.

Int J Mol Sci 2022 Apr 27;23(9). Epub 2022 Apr 27.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, 98166 Messina, Italy.

Migraine is a common brain-disorder that affects 15% of the population. Converging evidence shows that migraine is associated with gastrointestinal disorders. However, the mechanisms underlying the interaction between the gut and brain in patients with migraine are not clear. Read More

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Practice guidelines for the treatment of acute migraine and chronic knee osteoarthritis with paracetamol: an expert appraisal on evolution over time between scientific societies.

Curr Med Res Opin 2022 May 13:1-18. Epub 2022 May 13.

CETD and INSERM U987, Hôpital Ambroise Paré, APHP, Boulogne Billancourt, France.

Paracetamol is the commonest analgesic worldwide in primary care. Despite evidence-based recommendations for management of acute and chronic pain with paracetamol, practices seem vary considerably in its modalities of use, with or without restrictions, between renowned scientific societies and over time. Qualitative assessment of similarities, differences, and changes over time in guidelines for paracetamol use in acute and chronic pain. Read More

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[Comparison of tiapride and topiramate in the prophylactic treatment of chronic migraine: a randomised, double-blind, pilot study].

Rev Neurol 2022 May;74(10):325-330

Universidad de Concepción, Concepción, Chile.

Aim: The aim of this study was to evaluate the efficacy and safety of tiapride compared to topiramate as a prophylactic in chronic migraine.

Patients And Methods: The study was conducted under randomised and double blind conditions. A total of 56 patients aged 18-65 years with chronic migraine were assigned to two treatment arms: tiapride, 100 mg twice daily, or topiramate, 25 mg twice daily, for 12 weeks. Read More

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Prevention of medication overuse and medication overuse headache in patients with migraine: a randomized, controlled, parallel, allocation-blinded, multicenter, prospective trial using a mobile software application.

Trials 2022 May 11;23(1):382. Epub 2022 May 11.

Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.

Background: Overall, 55% of the German population suffers from primary episodic headaches according to recent studies. Inadequate management of headache disorders is a significant medical problem. The prevalence of medication overuse headache (MOH) is about 1% with an estimated number of 800,000 people in Germany. Read More

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Psychedelics in the Treatment of Headache and Chronic Pain Disorders.

Curr Top Behav Neurosci 2022 May 12. Epub 2022 May 12.

Headache Center of Excellence, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.

The therapeutic potential of psychedelics in headache and chronic pain disorders is documented over decades of anecdotal and early investigational reports, which have paved the way for the first controlled studies of psilocybin and lysergic acid diethylamide (LSD) in these disorders. The reported lasting clinical effects after limited dosing with psychedelics present a novel means for disease management, but considerable further study will be required to address disease-specific treatments, uncover mechanism(s) of action, and verify safety. In this chapter, these topics are reviewed with particular attention to the neurobiological systems that offer potential sources of psychedelics' unique clinical effects in headache and pain. Read More

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Headache associated with COVID-19: Epidemiology, characteristics, pathophysiology, and management.

Headache 2022 May 11. Epub 2022 May 11.

Division of Neuropsychiatry, Centro de Ciências Médicas, Universidade Federal de Pernambuco (UFPE), Recife, Brazil.

Objective: To review data regarding the epidemiology, pathophysiology, characteristics, and management of COVID-19-associated headache. The persistence of headache after the acute phase of COVID-19 was also reviewed.

Background: Headache is a frequent symptom of COVID-19, and understanding its management is important for health-care professionals involved in treating the disease. Read More

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[Electroacupuncture at Siguan points for migraine of liver hyperactivity: a randomized controlled trial].

Zhongguo Zhen Jiu 2022 May;42(5):498-502

Department of Acupuncture and Moxibustion, Affiliated Longhua Hospital of Shanghai University of TCM, Shanghai 200032, China.

Objective: To compare the clinical effect of electroacupuncture at Siguan points and flunarizine hydrochloride capsule on migraine of liver hyperactivity.

Methods: A total of 110 patients with migraine of liver hyperactivity were randomly divided into an electroacupuncture group (55 cases, 2 cases dropped off) and a western medication group (55 cases, 2 cases dropped off). In the electroacupuncture group, electroacupuncture was applied at Siguan points (Hegu [LI 4] and Taichong [LR 3]), with disperse-dense wave of 2 Hz/100 Hz in frequency and current intensity of 0. Read More

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Migraine chronique et dysfonction érectile.

Sara Arsever

Rev Med Suisse 2022 May;18(781):962

Unité de santé sexuelle et planning familial, Service de médecine de premier recours, Genève.

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The EAN Brain Health Strategy: One Brain, One Life, One Approach.

Eur J Neurol 2022 May 10. Epub 2022 May 10.

Department of Neurology, 4Brain, Institute for Neuroscience, Reference Center for Refractory Epilepsy, Ghent University Hospital, Ghent, Belgium.

Background: Brain health is essential for health, well-being productivity and creativity across the entire life. Its definition goes beyond the absence of disease embracing all cognitive, emotional, behavioural and social functions which are necessary to cope with life situations.

Methods: The EAN Brain Health Strategy responds to the high and increasing burden of neurological disorders. Read More

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Twelve-month safety, tolerability and susceptibility to adverse events of prophylactic migraine therapy with erenumab: a retrospective real-world study.

J Headache Pain 2022 May 11;23(1):55. Epub 2022 May 11.

Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), West German Headache Center, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.

Background: Erenumab is a monoclonal antibody (mAb) against the calcitonin gene related peptide (CGRP) receptor and is commonly used in migraine prophylaxis. Pivotal and open-label studies show a good safety and tolerability. However, little is known about possible predictors, dose dependence and time course of development of adverse events (AEs) during the treatment under real-world conditions. Read More

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Adult Hemimegalencephaly with Migraine as the First Symptom.

Neurol India 2022 Mar-Apr;70(2):788-789

Department of Neurology, Tianjin Huanhu Hospital, 6 Jizhao Road, Jinnan District, Tianjin, 300060, China.

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The nocebo response in pharmacologic treatments of primary headache: a systematic review and meta-analysis.

J Clin Pharmacol 2022 May 9. Epub 2022 May 9.

Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China.

The nature and magnitude of nocebo responses in primary headache disorders are still unknown. To assess the distribution and possible predictors of nocebo responses in primary headache treatments, databases including PubMed, EMBASE, and Cochrane Library were searched from 1988 to 31 December 2020 for parallel-group, double-blind, randomised placebo-controlled trials (RCTs) of pharmacologic treatments of primary headaches. The nocebo responses were calculated using a random effects meta-analysis model. Read More

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Stroke of Other Determined Etiology: Results From the Nationwide Multicenter Stroke Registry.

Stroke 2022 May 9:101161STROKEAHA121037582. Epub 2022 May 9.

Department of Neurology, Keimyung University Dongsan Medical Center, Daegu, Korea (S.I.S., J.-H.H.).

Background: Stroke of other determined etiology (OE) includes patients with an uncommon cause of stroke. We described the general characteristics, management, and outcomes of stroke in OE and its subgroups.

Methods: This study is a retrospective analysis of a prospective, multicenter, nationwide registry, the Clinical Research Center for Stroke-Korea-National Institutes of Health registry. Read More

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Assessing the performances of a chatbot to collect real-life data of patients suffering from primary headache disorders.

Digit Health 2022 Jan-Dec;8:20552076221097783. Epub 2022 May 3.

Wefight, Brain & Spine Institute, Paris, France.

Background: There are many scales for screening the impact of a disease. These scales are generally used to diagnose or assess the type and severity of a disease and are carried out by doctors. The chatbot helps patients suffering from primary headache disorders through personalized text messages. Read More

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Peripheral Nerve Stimulation for Chronic Pain and Migraine: A Review.

Phys Med Rehabil Clin N Am 2022 May;33(2):379-407

Department of Anesthesiology, Division of Pain Medicine, University of California, San Diego, CA, USA; Koman Family Outpatient Pavilion, Center for Pain Medicine, 9400 Campus Point Drive, MC 7328, La Jolla, CA 92037, USA.

Interventional pain procedures offer treatments for chronic pain conditions refractory to conservative measures. Neuromodulation, including peripheral nerve stimulation (PNS), applies electrical stimuli to neural structures to treat pain. Here we review the literature on PNS for various chronic pain conditions including neuropathic pain, postamputation pain, musculoskeletal pain, migraine, and pelvic pain. Read More

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Autonomic, Neurovascular Mechanisms in Migraine.

M J Quinn

Am J Med 2022 May;135(5):e111

Department of Pathology, Shanghai Jiao Tong University, International Peace Hospital for Maternal and Child Health, Shanghai, China. Electronic address:

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Migraine abortive treatment in children and adolescents in Israel.

Sci Rep 2022 May 6;12(1):7418. Epub 2022 May 6.

Department of Pediatric Neurology, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.

Migraine headaches in children may cause attacks that require abortive treatment. This study evaluated the incidence and efficacy of medications used for relieving migraine headache attacks in the pediatric population in Israel. Children 6-18 years of age who were diagnosed in our pediatric neurology clinic as having migraine headaches were enrolled into the study. Read More

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Insights from genomic studies on the role of sex steroids in the aetiology of endometriosis.

Reprod Fertil 2022 Apr 4;3(2):R51-R65. Epub 2022 Apr 4.

Centre for Inflammation Research, The University of Edinburgh, Edinburgh, UK.

Endometriosis is a chronic neuro-inflammatory disorder the defining feature of which is the growth of tissue (lesions) that resembles the endometrium outside the uterus. Estimates of prevalence quote rates of ~10% of women of reproductive age, equating to at least 190 million women world-wide. Genetic, hormonal and immunological factors have all been proposed as contributing to risk factors associated with the development of lesions. Read More

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Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage in Young Patients With a History of Migraine.

Stroke 2022 May 6:101161STROKEAHA121038350. Epub 2022 May 6.

Department of Neurology, Leiden University Medical Center, the Netherlands (H.J.A.v.O., M.J.H.W.).

Background: Young patients with aneurysmal subarachnoid hemorrhage (aSAH) and a history of migraine may have an increased risk of delayed cerebral ischemia. We investigated this potential association in a prospective cohort of aSAH patients under 50 years of age.

Methods: In our prospective cohort study, we included patients with aSAH under 50 years of age from 3 hospitals in the Netherlands. Read More

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Guidelines of the International Headache Society for Clinic-Based Headache Registries, 1 edition.

Cephalalgia 2022 May 6:3331024221099035. Epub 2022 May 6.

Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Clinic-based headache registries collect data for a wide variety of purposes including delineating disease characteristics, longitudinal natural disease courses, headache management approaches, quality of care, treatment safety and effectiveness, factors that predict treatment response, health care resource utilization, clinician adherence to guidelines, and cost-effectiveness. Registry data are valuable for numerous stakeholders, including individuals with headache disorders and their caregivers, healthcare providers, scientists, healthcare systems, regulatory authorities, pharmaceutical companies, employers, and policymakers. This International Headache Society document may serve as guidance for developing clinic-based headache registries. Read More

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