35,871 results match your criteria Migraine Variants


CGRP Antibodies as Prophylaxis in Migraine.

Authors:
Lars Edvinsson

Cell 2018 Dec;175(7):1719

Department of Medicine, University Hospital, Lund, Sweden. Electronic address:

Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (CLR + RAMP1) offer considerable improvements over existing drugs in migraine prophylaxis and are the first designed to act on the trigeminal pain system. Erenumab is approved by the FDA and EMA and has reached the market since May 2018. Two antibodies, fremanezumab and galcanezumab, directed towards the CGRP ligand, were approved by the FDA in September 2018. Read More

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December 2018

[Analysis of nystagmus and medical history of 121 patients positive with positional test].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1491-1494

Department of Otolaryngology, Kuang Tien General Hospital, Taichung, Taiwan.

To observe the characteristics of positional nystagmus and clinical profile of patients with positive positional test, and to explore its possible pathogenesis. One hundred and twenty-one patients with positive positional test in the vestibular function examination were enrolled in the Peking University International Hospital from January to June in 2017. According to the 2017 BPPV guidelines, patients with test positive positional nystagmus were divided into two groups: definite BPPV and the controversial syndrome. Read More

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October 2018

Illness Perception and Job Satisfaction in Patients Suffering from Migraine Headaches: Trait Anxiety and Depressive Symptoms as Potential Mediators.

Headache 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, S. Andrea Hospital, Sapienza University, Rome, Italy.

Background And Objectives: Migraine headache is the seventh leading cause of disability worldwide causing adverse outcomes in many aspects of an individual's life. Many psychological aspects affect chronic migraine (CM): illness perception, anxiety, depressive symptoms, and job satisfaction. This observational study aimed to examine the association among illness perception, anxiety, depressive symptoms, and job satisfaction, connected to migraine and its features. Read More

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December 2018

Advances in the understanding of headache in idiopathic intracranial hypertension.

Curr Opin Neurol 2018 Dec 12. Epub 2018 Dec 12.

Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston.

Purpose Of Review: To review the most relevant developments in the understanding of headache in idiopathic intracranial hypertension (IIH).

Recent Findings: The phenotype of the typical IIH headache is diverging from the historical thinking of a raised intracranial pressure headache, with the majority being classified as having migraine. A larger proportion of those with IIH have a past medical history of migraine, compared with the general population, highlighting the importance of re-examining those who have a change or escalation in their headache. Read More

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December 2018
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Prophylactic treatment of migraine with and without aura with acetyl-DL-leucine: a case series.

J Neurol 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurology, Ludwig Maximilians University, Munich, Campus Grosshadern, Marchioninistr. 15, 81377, Munich, Germany.

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December 2018

Fragranced consumer products: effects on autistic adults in the United States, Australia, and United Kingdom.

Authors:
Anne Steinemann

Air Qual Atmos Health 2018 25;11(10):1137-1142. Epub 2018 Sep 25.

1Department of Infrastructure Engineering, Melbourne School of Engineering, The University of Melbourne, Parkville, Victoria 3010 Australia.

Fragranced consumer products, such as cleaning supplies, air fresheners, and personal care products, can have adverse effects on both air quality and health. This study investigates the effects of fragranced products on autistic individuals ages 18-65 in the United States, Australia, and United Kingdom. Nationally representative population surveys ( = 1137; 1098; 1100) found that, across the three countries, 4. Read More

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September 2018
1 Read

A Novel NOTCH3 Gene Mutation in a Polish CADASIL Family.

J Stroke Cerebrovasc Dis 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurology, Pomeranian Medical University, Szczecin, Poland. Electronic address:

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a genetically determined disease of the cerebral vessels, characterized by recurrent ischemic strokes, dementia, and degeneration of the cerebral white matter. The condition is caused by a mutation in the NOTCH3 gene, whose product plays a great role in the development and physiology of the cardiovascular system. Magnetic resonance imaging reveals multiple hyperintensive lesions of the white matter in the T2-weighted images also in asymptomatic carriers of CADASIL and can be detected even 10-15 years prior to clinical signs. Read More

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December 2018

Evaluation of Electroencephalogram Using Exact Low-Resolution Electromagnetic Tomography During Photic Driving Response in Patients with Migraine.

Neuropsychobiology 2018 Dec 13:1-6. Epub 2018 Dec 13.

Department of Neurology, Dokkyo Medical University, Mibu,

Background: Photophobia is a common feature of migraine, which may involve abnormal cortical information processing. In electroencephalograms (EEG), photic driving is known as a reaction to visual stimulation. Both photophobia and photic driving response are present during light stimulation. Read More

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December 2018

Cost-effectiveness of noninvasive vagus nerve stimulation for acute treatment of episodic migraine and role in treatment sequence strategies.

Am J Manag Care 2018 Dec;24(24 Suppl):S527-S533

electroCore, Inc, Basking Ridge, NJ. Email:

Migraine affects 15% of the population in the United States and is associated with comorbidities, with an estimated economic burden of $78 billion annually. GammaCore is used adjunctively with current standard of care and abortive medications and has shown to be superior in acute treatment of episodic migraine compared to sham. However, the economic impact has not been characterized for this indication. Read More

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December 2018
2.264 Impact Factor

Review of evidence on noninvasive vagus nerve stimulation for treatment of migraine: efficacy, safety, and implications.

Am J Manag Care 2018 Dec;24(24 Suppl):S507-S516

electroCore, Inc, Basking Ridge, NJ. Email:

GammaCore was cleared by the FDA for the acute treatment of episodic migraine and episodic cluster headache and has 5 Conformité Européenne marks. Data indicate that gammaCore treatment is both safe and effective as an acute treatment for migraine. Current reimbursement policies need to be updated based on the growing body of evidence to reflect the established status of gammaCore that is no longer experimental. Read More

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December 2018
2.264 Impact Factor

A Stereotyped Syndrome with Retro-Ocular Pain, Photophobia, and Visual Disturbance Masquerading as Optic Neuritis: Case Series.

Neuroophthalmology 2018 Dec 15;42(6):339-342. Epub 2018 Aug 15.

Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK.

We describe here a case series of six patients referred to the Neuro-ophthalmology service in Sheffield, UK with possible acute unilateral optic neuritis. Each patient had a triad of unilateral photophobia, ipsilateral retro-ocular pain, and ipsilateral loss of vision. All patients had normal ocular examinations and investigation findings with no objective structural or functional abnormalities identified. Read More

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December 2018

The role of the otolaryngologist in the evaluation and management of headaches.

Am J Otolaryngol 2019 Jan - Feb;40(1):115-120. Epub 2018 Jul 7.

Department of Otolaryngology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, United States.

Background: Headaches are commonly evaluated in otolaryngology and often represent a diagnostic dilemma. This review addresses rhinogenic headache as well as trigeminal neuralgia and migraine, both of which can masquerade as sinus headache and whose management increasingly involves otolaryngology intervention. Discussion considers diagnostic criteria and novel therapies and derives an algorithm for clinical decision-making. Read More

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The pathological spectrum behind migraine aura status: a case series.

Neurol Sci 2018 Dec 6. Epub 2018 Dec 6.

Department of Neuroscience, University of Padova, Via Giustiniani 5, 35128, Padova, Italy.

Background: The recently released International Classification of Headache Disorders-3rd edition (1) includes migraine aura status (MAS) among the complications of migraine (A1.4.5). Read More

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December 2018

Red ear syndrome: Perspectives for the otolaryngologist.

Ear Nose Throat J 2018 Dec;97(12):E11-E14

Department of Otolaryngology, Lenox Hill Hospital/Northwell Health, 110-11 72nd Ave., Suite 1B, Forest Hills, NY 11375, USA.

Red ear syndrome (RES) is an unusual, often unrecognized condition that has rarely been reported in the otolaryngology literature despite the presence of symptoms and associated disorders of relevance to the otolaryngologist. When present, RES may have diagnostic value when uncertainties arise in cases of sinus headache and referred otalgia. Despite the appearance of a distinctive red ear, as well as symptoms and associated disorders relating to otolaryngology, discussion of RES is generally limited to neurology-based publications. Read More

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December 2018
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Preinjury and Postinjury Factors That Predict Sports-Related Concussion and Clinical Recovery Time.

Clin J Sport Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychology, University of Missouri-Kansas City, Kansas City, Missouri.

Objectives: To evaluate the relationship between preinjury risk factors (RFs) and subsequent occurrence of concussion and examine whether preinjury RFs or postinjury assessments predict clinical recovery in collegiate athletes.

Methods: Risk factors (sex, sport, and self-report history of concussion, migraine, attention-deficit disorder, learning disability, depression, and anxiety) and Sport Concussion Assessment Tool (SCAT), depression/anxiety screenings, and neuropsychological testing were obtained before the season. For athletes who sustained concussion, RFs, postinjury SCAT, neuropsychological assessment, and clinical recovery were assessed. Read More

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December 2018

Basics on the use of acid-sensing ion channels' inhibitors as therapeutics.

Neural Regen Res 2019 Mar;14(3):395-398

North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, USA.

Since the discovery of acid-sensing ion channels in 1997, their importance in the health of neurons and other non-neuronal cells has gained significant importance. Acid-sensing ion channels play important roles in mediating pain sensation during diseases such as stroke, inflammation, arthritis, cancer, and recently migraine. More interestingly, acid-sensing ion channels may explain the sex differences in pain between males and females. Read More

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March 2019
2 Reads

Non-pharmacological Approaches for Headaches in Young Age: An Updated Review.

Front Neurol 2018 27;9:1009. Epub 2018 Nov 27.

Neurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Neurology, Milan, Italy.

Headache disorders are common in children and adolescents. Most of the studies on non-pharmacological treatments have however been carried out on adults. In this review we provide information on recent studies examining non-pharmacological approaches for managing headache in children and adolescents. Read More

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November 2018

Crystal structure of the human NK tachykinin receptor.

Proc Natl Acad Sci U S A 2018 Dec 11. Epub 2018 Dec 11.

Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390;

The NK tachykinin G-protein-coupled receptor (GPCR) binds substance P, the first neuropeptide to be discovered in mammals. Through activation of NKR, substance P modulates a wide variety of physiological and disease processes including nociception, inflammation, and depression. Human NKR (hNKR) modulators have shown promise in clinical trials for migraine, depression, and emesis. Read More

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December 2018
1 Read

Cerebral Venous Thrombosis: An Uncommon Cause of Papilledema on Bedside Ocular Ultrasound.

J Emerg Med 2018 Dec 8. Epub 2018 Dec 8.

Department of Emergency Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, Florida.

Background: Cerebral venous thrombosis (CVT) is a rare, difficult-to-diagnose form of venous thromboembolic disease and is considered a type of stroke. Its presentation is highly variable and may be easily confused for more common and less debilitating or life-threatening diagnoses such as migraine, seizure, or idiopathic intracranial hypertension.

Case Report: A 25-year-old woman presented with a complaint of bifrontal throbbing headache and blurry vision. Read More

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December 2018

Influence of patient positioning on reported clinical outcomes after greater occipital nerve block for treatment of headache: Results from prospective single-centre, non-randomised, proof-of-concept study.

Clin Neurol Neurosurg 2018 Dec 3;176:73-77. Epub 2018 Dec 3.

Science & Innovation Manager, R&D Department, Cumbria Partnership NHS Foundation Trust, Carlisle, CA1 3SX, UK. Electronic address:

Objective: Greater occipital nerve (GON) block is a treatment option applied for a variety of primary headache disorders. Although a patient's body position is known to have an impact on the effect of local anaesthetics, this has not before been investigated for patients undergoing GON block. Therefore, the clinical effectiveness of either a sitting or supine position was assessed. Read More

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December 2018
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The American Headache Society Position Statement On Integrating New Migraine Treatments Into Clinical Practice.

Authors:

Headache 2018 Dec 10. Epub 2018 Dec 10.

Objective: To provide healthcare professionals with updated guidance in the use of novel preventive and acute treatments for migraine in adults.

Background: The principles of preventive and acute pharmacotherapy for patients with migraine have been outlined previously, but the emergence of new technologies and treatments, as well as new formulations of previously established treatments, has created a need for an updated guidance on the preventive and acute treatment of migraine.

Methods: This statement is based on a review of existing guidelines and principles for preventive and acute treatment of migraine, as well as the results of recent clinical trials of drugs and devices for these indications. Read More

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December 2018
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An Intraperitoneal Treatment with Calcitonin Gene-Related Peptide (CGRP) Regulates Appetite, Energy Intake/Expenditure, and Metabolism.

J Mol Neurosci 2018 Dec 10. Epub 2018 Dec 10.

CURE/Digestive Diseases Research Center, Department of Medicine at the David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide expressed both centrally and peripherally. CGRP has been shown to be involved in arteriolar dilation, cardiovascular regulation, pain transmission, migraine, and gastrointestinal physiology. Our current research is aimed at analyzing CGRP's impact on appetite/satiety, body metabolism, and energy homeostasis. Read More

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December 2018
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'Lost My Way' - Transient Topographic Amnesia: A Bizarre Manifestation of Migraine.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):341-343

Department of Radiodiagnosis, Government Medical College, Thiruvananthapuram, Kerala, India.

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December 2018

A novel large animal model of recurrent migraine established by repeated administration of inflammatory soup into the dura mater of the rhesus monkey.

Neural Regen Res 2019 Jan;14(1):100-106

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Several animal models of migraine have been established, and those based on trigeminovascular system activation are widely accepted. However, most of these models have been established on lower animals, such as rodents, and involve only a single administration of a noxious stimulus. In this study, an inflammatory soup (10 μL), consisting of prostaglandin E2 (0. Read More

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January 2019

Progression in migraine: role of mast cells and pro-inflammatory and anti-inflammatory cytokines.

Eur J Pharmacol 2018 Dec 6. Epub 2018 Dec 6.

UOS Clinica dei Pazienti del Territorio, Policlinico Gemelli, Rome, Italy. Electronic address:

Migraine is a common painful neurovascular disorder usually associated with several symptoms, such as photophobia, phonophobia, nausea, vomiting and inflammation, and involves immune cells. Mast cells (MCs) are immune cells derived from hematopoietic pluripotent stem cells which migrate and mature close to epithelial, blood vessels, and nerves. In almost all vascularized tissues there are MCs that produce, contain and release biologically active products including cytokines, arachidonic acid compounds, and proteases. Read More

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December 2018
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[Validity and applicability of the mnemonic POUNDing rule in patients with migraine. A descriptive study].

Semergen 2018 Dec 7. Epub 2018 Dec 7.

Centro de Salud Universitario La Paz, Servicio Extremeño de Salud, Badajoz, España. Electronic address:

Introduction: In assessing the patient with headache, clinicians are often faced with 2 important questions: Is this headache a migraine? Does this patient require neuroimaging? The aim of this study was to assess the validity and applicability of the mnemonic POUNDing rule in patients diagnosed with migraine.

Patients And Methods: A descriptive, validation study of the POUNDing rule in patients with a diagnosis of migraines and with a brain imaging test (computed tomography or magnetic resonance imaging), in an urban health centre and a neurology clinic of the University Hospital of Badajoz.

Results: A total of 116 patients were included (mean age 45. Read More

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December 2018
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New Insights into the Regulation of CGRP-Family Receptors.

Trends Pharmacol Sci 2018 Dec 4. Epub 2018 Dec 4.

School of Biological Sciences, University of Auckland, Auckland, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand. Electronic address:

The calcitonin gene-related peptide (CGRP) receptor system has emerged as an important drug target for migraine. This is highlighted by the recent regulatory approval of the first drug targeting the CGRP signalling pathway, the CGRP receptor antibody erenumab. The cellular compartments in which receptors are found affects drug access and whether they can exert their effects. Read More

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December 2018

Individual Differences in Sensory Sensitivity: A Synthesising Framework and Evidence from Normal Variation and Developmental Conditions.

Authors:
Jamie Ward

Cogn Neurosci 2018 Dec 10. Epub 2018 Dec 10.

a School of Psychology , University of Sussex , Brighton , UK.

For some people, simple sensory stimuli (e.g. noises, patterns) may reliably evoke intense and aversive reactions. Read More

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December 2018

Pharmacotherapy for acute migraines in children and adolescents.

Expert Opin Pharmacother 2018 Dec 7:1-9. Epub 2018 Dec 7.

a Headache and Pain Unit, Department of Neurological , Motor and Sensorial Sciences; IRCCS San Raffaele Pisana , Rome , Italy.

Introduction: Migraine is increasingly recognized as an extremely burdensome and disabling disorder in both children and adolescents. A proper treatment plan is needed to improve the quality of life of both children and families as well as to minimize the risk of disease progression. Areas covered: This review focuses on the current pharmacotherapy for acute migraine in pediatric populations, taking into account specific considerations for those drugs tested in randomized, placebo-controlled trials (RCTs). Read More

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December 2018

Cortical abnormalities in episodic migraine: A multi-center 3T MRI study.

Cephalalgia 2018 Dec 10:333102418795163. Epub 2018 Dec 10.

1 Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland.

Background: Several previous studies have investigated cortical abnormalities, specifically cortical thickness, in patients with migraine, with variable results. The relatively small sample sizes of most previous studies may partially explain these inconsistencies.

Objective: To investigate differences of cortical thickness between control subjects and migraineurs in a large cohort. Read More

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December 2018
1 Read

Headache in Pregnancy, the Puerperium, and menopause.

Semin Neurol 2018 Dec 6;38(6):627-633. Epub 2018 Dec 6.

Department of Neurology, University at Buffalo School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York.

Headache is a neurologic disorder that displays gender dichotomy. It is well established that there is a strong link between migraine headache and sex hormones, specifically estrogen, which influences the severity of migraines during the menstrual cycle, pregnancy, and menopause. Furthermore, the epidemiology of headaches during pregnancy and the postpartum period is very distinct from that in males or nonpregnant females, in part due to the hemodynamic and hematologic changes that occur during pregnancy. Read More

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December 2018
3 Reads

Posttraumatic Headache.

Authors:
Brigid Dwyer

Semin Neurol 2018 Dec 6;38(6):619-626. Epub 2018 Dec 6.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.

Posttraumatic headaches are among the most challenging complaints after mild traumatic brain injury (mTBI). They are a debilitating problem experienced by patients after TBI of all severities. Up to 90% of mild TBI patients experience headache, particularly if female and with a premorbid history of primary headache. Read More

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December 2018
5 Reads

Migraine and Tension-Type Headache.

Semin Neurol 2018 Dec 6;38(6):608-618. Epub 2018 Dec 6.

Department of Neurology, Boston Medical Center, Boston, Massachusetts.

Migraine and tension-type headache (TTH) are common primary disorders that carry significant morbidity and socioeconomic effect. In this article, we will review the epidemiology, presentation, and diagnosis of these disorders. First-line acute treatment for migraine consists of analgesics, triptans, and antiemetics, while nonsteroidal anti-inflammatory drugs are the mainstay treatment for TTH. Read More

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December 2018
3 Reads

Astrocyte elevated gene-1 induces autophagy in diabetic cardiomyopathy through upregulation of KLF4.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China.

Background: Astrocyte elevated gene-1 (AEG-1), also known as metadherin, 3D3, and lysine-rich carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) coisolated, has emerged as an important oncogene that is overexpressed in a variety of cancers. Previous studies revealed that AEG-1 is also involved in multiple physiological and pathological processes, such as development, inflammation, neurodegeneration, migraine, and Huntington's disease. However, the function of AEG-1 in diabetic cardiomyopathy (DCM) has not been reported yet. Read More

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December 2018
1 Read

Clinical observation of the effect of prophylaxis on allodynia in patients with migraine.

J Pain Res 2018 2;11:2721-2728. Epub 2018 Nov 2.

Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China,

Objective: The clinical characteristics of migraine with and without allodynia were compared to evaluate the risk factors of cutaneous allodynia in migraine. The effects of prophylactic therapy on allodynia in patients with migraine were assessed based on the change in pain threshold after therapy.

Patients And Methods: A total of 71 patients with migraine admitted to the Department of Neurology of Shandong Provincial Hospital were recruited in this study. Read More

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November 2018
2 Reads

Economic analysis of acupuncture for migraine prophylaxis.

Neuropsychiatr Dis Treat 2018 12;14:3053-3061. Epub 2018 Nov 12.

Czech-Chinese Centre for Traditional Chinese Medicine, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic,

Background: Acupuncture has become a viable option for migraine prophylaxis in Europe; however, despite its wide use, more data on the short- and long-term cost-effectiveness are needed when considering the perspectives of a paying third-party, the patient, and of society in general. The aim was to evaluate the cost and effectiveness of adjuvant acupuncture to pharmacologic treatment vs pharmacologic treatment alone in migraine patients after a 3-month acupuncture course and a 6-month follow-up from all perspectives.

Methods: The study involved an open-label randomized clinical trial of patients receiving acupuncture (n=42), and a waiting list control group (n=44). Read More

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November 2018

Patient satisfaction, health care resource utilization, and acute headache medication use with galcanezumab: results from a 12-month open-label study in patients with migraine.

Patient Prefer Adherence 2018 13;12:2413-2424. Epub 2018 Nov 13.

Department of Neurology - Headache and Facial Pain Clinic, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), 1090 Brussels, Belgium.

Background: Effects of galcanezumab, a monoclonal antibody against calcitonin gene-related peptide, on patient satisfaction, health care resource utilization (HCRU), and acute medication use were evaluated in a long-term, open-label study in patients with migraine.

Methods: Patients with episodic (78.9%) or chronic migraine (21. Read More

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November 2018
1 Read

Postoperative Visual Loss: A Report of One Patient With Unilateral Blindness After Orthognathic Surgery.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Oral and Maxillofacial Department, Roger Salengro Hospital, CHU Lille.

Introduction: Blindness after orthognathic surgery may be the result of the surgical procedure itself or the consequence of factors induced by general anesthesia. However, the exact mechanism between is not known. The purpose of this article is to present a case of a postoperative visual loss after orthognathic surgery under general anesthesia concluding with a brief literature review about this topic. Read More

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November 2018
1 Read

Clinical significance of sensory hypersensitivities in migraine patients: does allodynia have a priority on it?

Neurol Sci 2018 Dec 1. Epub 2018 Dec 1.

Department of Neurology, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu, 41944, Republic of Korea.

Objectives: This study investigated to identify the clinical significance of allodynia compared with other sensory hypersensitivities (SH) in migraine patients.

Methods: New patients with migraine were recruited from a headache clinic, and we collected data regarding their clinical characteristics and identified SH including photophobia, phonophobia, osmophobia, and allodynia. The patients completed the 12-item Allodynia Symptom Checklist, Migraine Disability Assessment Scale (MIDAS), Headache Impact Test-6 (HIT-6), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), Insomnia Severity Index (ISI), Fatigue Severity Scale (FSS), and Migraine-Specific Quality of Life Questionnaire Version 2. Read More

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December 2018
1 Read

Headache in the course of multiple sclerosis: a prospective study.

J Neural Transm (Vienna) 2018 Nov 30. Epub 2018 Nov 30.

Neuroimmunological Section, Department of Neurology, University of Rostock, Rostock, Germany.

Multiple sclerosis (MS) is the most common immune-mediated inflammatory disease of the central nervous system (CNS). Early diagnosis and treatment is important to prevent progression of disability in the course of the chronic disease. Therefore, correct and fast identification of early symptoms is vital. Read More

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November 2018
1 Read

Quantitative analysis of the retinal nerve fiber layer, ganglion cell layer and optic disc parameters by the swept source optical coherence tomography in patients with migraine and patients with tension-type headache.

Acta Neurol Belg 2018 Nov 30. Epub 2018 Nov 30.

Department of Neurology, Keçiören Training and Research Hospital, Ankara, Turkey.

The aim of the study was to measure the thicknesses of the inner retinal segments and optic nerve head (ONH) parameters in migraineurs and patients with tension-type headache (TTH) in headache-free period using swept source optical coherence tomography (SS-OCT) and to compare the outcomes with each other and those of healthy subjects. The study population consisted of 23 migraineurs, 22 TTH patients, and 25 controls with a best-corrected visual acuity of 20/20 and without a history of systemic or ocular disease. Macular ganglion cell inner plexiform layer (mGCIPL), macular ganglion cell complex (mGCC), circumpapillary retinal nerve fiber layer (cpRNFL), and ONH parameters were evaluated using SS-OCT, and the areas under the receiver-operating characteristic (ROC) curves were calculated to determine the ability of these parameters to distinguish between the patient and normal eyes. Read More

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November 2018
1 Read

[Approach to patients with vertigo].

Medicina (B Aires) 2018 ;78(6):410-416

Servicio de Otorrinolaringología, Hospital Británico de Buenos Aires, Argentina.

Vertigo is defined as an abnormal sensation of body motion or of its surrounding objects. It is a common chief complaint in emergency departments comprising 2 to 3% of these consultations worldwide. Vertigo is classified as peripheral or central, according to its origin, and can also be occasionally mixed, the most common cause of peripheral involvement being benign paroxysmal positional vertigo. Read More

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January 2018
6 Reads

Propranolol prevents cerebral blood flow changes and pain-related behaviors in migraine model mice.

Biochem Biophys Res Commun 2018 Nov 29. Epub 2018 Nov 29.

Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan. Electronic address:

Propranolol, a β-adrenergic receptor blocker, is one of the most commonly used prophylactic drugs for migraines. Cortical spreading depression (CSD) is the propagation wave of neuronal excitation along with cerebral blood flow (CBF) changes over the cerebral cortex and has been implicated in the pathological process of migraine auras and its pain response. However, the effect of propranolol on CSD-related CBF changes and behavioral responses remains poorly understood. Read More

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November 2018

CGRP/CGRP Receptor Antibodies: Potential Adverse Effects Due to Blockade of Neovascularization?

Trends Pharmacol Sci 2018 Nov 28. Epub 2018 Nov 28.

Department of Pharmacology, Kitasato University School of Medicine and Department of Molecular Pharmacology, Kitasato University Graduate School of Medical Sciences, Sagamihara, Kanagawa 252-0374, Japan.

Migraine is a severe neurological disorder in which calcitonin gene-related peptide (CGRP) is a key molecule in pathophysiology. Neuronal system-derived CGRP enhances neovascularization in several important pathological conditions and sends a cue to the vascular system. In 2018, the FDA approved erenumab and fremanezumab, antibodies against CGRP receptor and CGRP, as the first new class of drugs for migraine. Read More

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November 2018

Botulinum toxin in women's health: An update.

Maturitas 2019 Jan 22;119:21-24. Epub 2018 Oct 22.

The Royal Women's Hospital, 20 Flemington Road Parkville, Victoria 3052 Australia; The University of Melbourne, Department of Obstetrics and Gynaecology, 7thFloor Royal Women's Hospital, 20 Flemington Road Parkville, Victoria 3052 Australia. Electronic address:

Botulinum toxin, from the bacteria Clostridium botulinum, acts by block the pre-synaptic release of acetylcholine at the neuromuscular junction, resulting in temporary muscle paralysis. There are several clinically available formulations, the most extensively studied being of onabotulinumtoxinA. This article outlines three of the common clinical applications of onabotulinumtoxinA relevant to women's health: the management of symptoms of overactive bladder, chronic migraine and facial lines. Read More

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January 2019
2 Reads

Acute-Onset Ataxia and Transient Cerebellar Diffusion Restriction Associated with a PRRT2 Mutation.

J Stroke Cerebrovasc Dis 2018 Nov 28. Epub 2018 Nov 28.

Neurology Department, Bicêtre Hospital, Assistance Publique des Hôpitaux de Paris, (AP-HP), Paris, France.

PRRT2 gene mutations cause paroxysmal kinesigenic dyskinesia (PKD), infantile convulsions, hemiplegic migraine, and episodic ataxia. A 21-year-old woman reported an episode of dizziness and ataxic gait occurring after swimming. Brain MRI showed a hyperintense cerebellar lesion on diffusion-weighted imaging (DWI) with decreased apparent diffusion coefficient. Read More

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November 2018
1 Read

Amplification of glyceryl trinitrate-induced headache features by noxious craniofacial stimuli in pain-free healthy humans.

Pain Manag 2018 Dec 3. Epub 2018 Dec 3.

Unit of Clinical Biostatistics and Bioinformatics, Aalborg University Hospital North, Aalborg, Denmark.

Aim: Glyceryl trinitrate (GTN) provokes an immediate migraine-like headache, followed by a delayed migraine attack in migraineurs. In healthy volunteers, only an immediate, less severe and shorter headache occurs. The presence of an already sensitized nervous system in migraineurs may underlie the more intense and prolonged GTN-evoked headaches. Read More

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December 2018
2 Reads

Migraine and Markers of Carotid Atherosclerosis in Middle-Aged Women: A Cross-Sectional Study.

Headache 2018 Dec 5. Epub 2018 Dec 5.

Division of Neurology, Hospital Universitário Oswaldo Cruz of the Universidade de Pernambuco, Recife, Brazil.

Objective: This study evaluated the association between migraine and the markers of carotid artery disease.

Background: Migraine increases the risk of cardiovascular events, but its relationship with vascular dysfunction is unclear.

Methods: In this cross-sectional study, middle-aged women with no known cardiovascular diseases underwent clinical, neurological, and laboratory evaluations; pulse wave velocity (PWV) assessment; and carotid artery ultrasonography. Read More

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December 2018
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Use of traditional medicine for primary headache disorders in Kuwait.

J Headache Pain 2018 Dec 4;19(1):118. Epub 2018 Dec 4.

Division of Neurology, Amiri Hospital, P.O. Box 1661, Qurtoba, 73767, Kuwait City, Kuwait.

Background: Traditional Medicine (TM) is widely accepted to be used for the treatment headache disorders in Kuwait however, researches remain poorly documented. We aimed to study the frequency of TM use and its impact in the primary headache patients.

Methods: This is a cross sectional self-reported efficacy study, which was conducted in Headache clinic in Kuwait throughout 6 months. Read More

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December 2018

HaNDL Syndrome: Case Report and Literature Review.

J Child Neurol 2018 Dec 5:883073818811546. Epub 2018 Dec 5.

1 Department of Pediatric Neurology, Massachusetts General Hospital, Boston, MA, USA.

Headache and Neurologic Deficits with cerebrospinal fluid Lymphocytosis (HaNDL) syndrome is a rare stroke mimicker characterized by moderate to severe headache temporally associated with transient neurologic deficits, typically hemiparesis, hemisensory disturbance, and/or aphasia. Cerebrospinal fluid studies reveal a lymphocytosis and elevated protein. Episodes recur over a period no longer than 3 months. Read More

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December 2018
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