32,385 results match your criteria Migraine Variants

Gait control of migraine patients with increasing light and sound levels.

Gait Posture 2021 Apr 5. Epub 2021 Apr 5.

University of Sao Paulo, Department of Health Sciences, Address: Av. Bandeirantes, 3900 - Vila Monte Alegre, Ribeirão Preto, BR 14049-900, Brazil. Electronic address:

Background: Under a typical light and sound environment context, individuals with migraine showed balance control deficits on a series of functional activities, which helps to explain why migraineurs report more falls. it isn't established, the effects of intensity light and sound in migraineurs during functional tasks.

Research Question: Based on the hypersensitivity to light and sound in migraineurs, not only during the attack but also in the interictal period, does the exposure to bright light and loud sound impact motor control in this population?

Methods: This cross-sectional study consisted of 51 women with migraine and 22 healthy women. Read More

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Migraine prevalence in visual snow with prior illicit drug use (Hallucinogen Persisting Perception Disorder) versus without.

Eur J Neurol 2021 May 12. Epub 2021 May 12.

Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.

Background/objective: To investigate migraine prevalence in persons with Hallucinogen Persisting Perception Disorder (HPPD) presenting as visual snow syndrome (VSS).

Methods: Persons with visual snow as persisting symptom after illicit drug use (HPPD) were recruited via a Dutch consulting clinic for recreational drug use. A structured interview on (visual) perceptual symptomatology, details of drugs use, medical and headache history was taken. Read More

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Diagnosis and Management of Headache: A Review.

JAMA 2021 May;325(18):1874-1885

Department of Neurology, Weill Cornell Medical College, New York, New York.

Importance: Approximately 90% of people in the US experience headache during their lifetime. Migraine is the second leading cause of years lived with disability worldwide.

Observations: Primary headache disorders are defined as headaches that are unrelated to an underlying medical condition and are categorized into 4 groups: migraine, tension-type headache, trigeminal autonomic cephalalgias, and other primary headache disorders. Read More

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Retinal Migraine: Evaluation and Management.

Curr Neurol Neurosci Rep 2021 May 11;21(7):35. Epub 2021 May 11.

Division of Neurology, University of Toronto, Toronto, Canada.

Purpose Of Review: This review aims to summarize the last 15 years of literature and case reports detailing retinal migraine-an uncommon and somewhat poorly understood migraine variant.

Recent Findings: In the last 15 years, only 12 cases of retinal migraine have been outlined. Similar to other migraine statistics, retinal migraine appears to affect women more so than men and presents with unilateral headache which tends to be ipsilateral to the side of vision loss. Read More

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Autism medical comorbidities.

World J Clin Pediatr 2021 May 9;10(3):15-28. Epub 2021 May 9.

Department of Pediatrics, University Medical Center, King Abdulla Medical City, Arabian Gulf University, Manama P.O. Box 26671, Bahrain, Bahrain.

Medical comorbidities are more common in children with autism spectrum disorders (ASD) than in the general population. Some genetic disorders are more common in children with ASD such as Fragile X syndrome, Down syndrome, Duchenne muscular dystrophy, neurofibromatosis type I, and tuberous sclerosis complex. Children with autism are also more prone to a variety of neurological disorders, including epilepsy, macrocephaly, hydrocephalus, cerebral palsy, migraine/headaches, and congenital abnormalities of the nervous system. Read More

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Effects of the Menstrual Cycle on Neurological Disorders.

Curr Neurol Neurosci Rep 2021 May 10;21(7):34. Epub 2021 May 10.

Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Purpose Of Review: The menstrual cycle involves recurrent fluctuations in hormone levels and temperature via neuroendocrine feedback loops. This paper reviews the impact of the menstrual cycle on several common neurological conditions, including migraine, seizures, multiple sclerosis, stroke, and Parkinson's disease.

Recent Findings: The ovarian steroid hormones, estrogen and progesterone, have protean effects on central nervous system functioning that can impact the likelihood, severity, and presentation of many neurological diseases. Read More

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Prevalence of Occipital Neuralgia at a Community Hospital-based Headache Clinic.

Neurol Clin Pract 2021 Feb;11(1):6-12

Department of Neurology (PGM), Brigham and Women's Hospital, Boston; Department of Neurology (PGM), Harvard Vanguard Medical Associates, Braintree; Division of Neurology (PGM), Cambridge Health Alliance; Harvard Medical School (PGM), Boston, MA; Department of Neurology (UN), West Virginia University, School of Medicine, Morgantown, WV; St. George's University (SK), School of Medicine, Grenada, WI; Hackensack Meridian School of Medicine at Seton Hall University (RK), Nutley; and Neuroscience Institute at Hackensack University Medical Center (RK), Hackensack, NJ.

Background: Occipital neuralgia (ON) is a paroxysmal disorder involving lancinating pain that originates in the neck or skull base with superior radiation toward the apex. ON more commonly occurs in patients with other coexisting headache disorders. There are limited data regarding the prevalence of ON. Read More

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February 2021

Migraine and stress-an exploratory cross-country study of external stress factors.

BMC Res Notes 2021 May 8;14(1):174. Epub 2021 May 8.

Institute of Social Studies, Erasmus University Rotterdam, Kortenaerkade 12, 2518 AX, The Hague, The Netherlands.

Objective: The data collected by the Global Burden of Disease 2016 project indicate that migraine ranks second in high-income countries with very competitive and flexible labour markets, and first in low- and middle-income countries suffering from civic unrest and conflict. This raises the question whether external stress factors may be correlated with migraine years lived with disability per 100,000 inhabitants (YLD). The objective of this exploratory study is to test the hypothesis that external stress factors are correlated with the prevalence and severity of migraine at the country level. Read More

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Vestibular disorders in children: A retrospective analysis of vestibular function test findings.

Int J Pediatr Otorhinolaryngol 2021 Apr 29;146:110751. Epub 2021 Apr 29.

Acibadem Maslak Hospital ENT Department, Istanbul, Turkey.

Objective: This study was designed to describe the most common vestibular disorders in children and their associated findings on vestibular function testing.

Method: Data from 203 children with a mean age of 11.16 ± 3. Read More

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Temporomandibular-disorder-related pain as a predictor of severe headaches.

Community Dent Oral Epidemiol 2021 May 7. Epub 2021 May 7.

Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.

Objective: The current study aimed to investigate the association of temporomandibular disorders (TMD)-related pain with the presence of migraine or tension-type headaches (TTH) over a follow-up period of 11 years.

Methods: Data sets from Finnish national health surveys, the Health 2000 Survey (baseline), and the Health 2011 Survey (follow-up) were utilized. Study participants are undergoing clinical TMD examination at baseline and answering questions related to the presence of migraine and TTH at follow-up were included in the study (n = 530). Read More

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[Headache in old age].

Andreas Straube

MMW Fortschr Med 2021 05;163(9):58-63

Neurologische Klinik \/ Kopfschmerzzentrum, Klinikum Großhadern d. LMU München, Marchioninistr. 15, 81377, München, Germany.

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Pathophysiological Bases of Comorbidity in Migraine.

Front Hum Neurosci 2021 20;15:640574. Epub 2021 Apr 20.

Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy.

Despite that it is commonly accepted that migraine is a disorder of the nervous system with a prominent genetic basis, it is comorbid with a plethora of medical conditions. Several studies have found bidirectional comorbidity between migraine and different disorders including neurological, psychiatric, cardio- and cerebrovascular, gastrointestinal, metaboloendocrine, and immunological conditions. Each of these has its own genetic load and shares some common characteristics with migraine. Read More

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Burden of disease and lifestyle habits in adolescents and young adults prone to frequent episodic migraine: A secondary comparative analysis.

J Child Health Care 2021 May 6:13674935211008712. Epub 2021 May 6.

Department of Pediatric Neurology and Developmental Medicine and LMU Center for Children with Medical Complexity, Dr von Hauner Children's Hospital, LMU Hospital, 54187Ludwig-Maximilians-Universität, Germany.

The objective of this study was to assess the burden of disease and prevalence of lifestyle factors for adolescents and young adults with frequent episodic migraine. We conducted a secondary comparative analysis of data collected during two previous studies. Inclusion criteria for this analysis were age 15-35 years, 15 to 44 migraine episodes within 12 weeks, and completeness of Migraine Disability Assessment and lifestyle questionnaire data. Read More

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Phenotype of Cluster Headache: Clinical Variability, Persisting Pain Between Attacks, and Comorbidities-An Observational Cohort Study in 825 Patients.

Pain Ther 2021 May 4. Epub 2021 May 4.

Kiel Migraine and Headache Centre, Kiel, Germany.

Introduction: Cluster headaches can occur with considerable clinical variability. The inter- and intra-individual variability could contribute to the fact that the clinical headache phenotype is not captured by too strict diagnostic criteria, and that the diagnosis and the effective therapy are thereby delayed. The aim of the study was to analyze the severity and extent of the clinical symptoms of episodic and chronic cluster headaches with regard to their variability and to compare them with the requirements of the International Classification of Headache Disorders 3rd edition (ICHD-3) diagnostic criteria. Read More

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A Single Supratherapeutic Dose of Atogepant Does Not Affect Cardiac Repolarization in Healthy Adults: Results From a Randomized, Single-Dose, Phase 1 Crossover Trial.

Clin Pharmacol Drug Dev 2021 May 4. Epub 2021 May 4.

AbbVie, Madison, New Jersey, USA.

Atogepant is a selective, oral calcitonin gene-related peptide receptor antagonist in development for preventive treatment of migraine. This randomized, double-blind, phase 1 crossover study evaluated the cardiac repolarization effect of a single supratherapeutic (300 mg) atogepant dose vs placebo in healthy adults. Moxifloxacin 400 mg was the open-label active control. Read More

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Decline in attentional inhibition among migraine patients: an event-related potential study using the Stroop task.

J Headache Pain 2021 May 3;22(1):34. Epub 2021 May 3.

Department of Neurology, the First Medical Center, Chinese PLA General Hospital, 100853, Beijing, China.

Background: As a disorder of brain dysfunction, migraine has been associated with cognitive decline. However, no consistent results with respect to the attention function in migraineurs have been found, and the relationship between attentional inhibition and migraine is also unclear. In this study, the attentional inhibition function was evaluated using event-related potentials (ERPs) while migraine patients and healthy controls were performing the color-word Stroop task. Read More

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Galcanezumab for the prevention of high frequency episodic and chronic migraine in real life in Italy: a multicenter prospective cohort study (the GARLIT study).

J Headache Pain 2021 May 3;22(1):35. Epub 2021 May 3.

Headache and Pain Unit, IRCCS San Raffaele Pisana, Rome, Italy.

Background: The clinical benefit of galcanezumab, demonstrated in randomized clinical trials (RCTs), remains to be quantified in real life. This study aimed at evaluating the effectiveness, safety and tolerability of galcanezumab in the prevention of high-frequency episodic migraine (HFEM) and chronic migraine (CM) in a real-life setting.

Methods: This multicenter prospective observational cohort study was conducted between November 2019 and January 2021 at 13 Italian headache centers. Read More

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The first prevalence study of primary headaches in adults in a post-conflict area of Serbia.

Cephalalgia 2021 May 2:3331024211006043. Epub 2021 May 2.

University of Belgrade, Faculty of Medicine, Institute of Epidemiology, Belgrade, Serbia.

Aim: The aim of the present study was to establish annual prevalence of primary headaches, migraine, and tension-type headache among adults in a post-conflict area of Serbia.

Methods: The data for this cross-sectional study was obtained via face-to-face interviews using questionnaires specifically designed for this purpose, in line with the available guidelines. The study sample included adults aged 18-65 years whose native language is Serbian with residence in six predominantly Serbian communities in Kosovo and Metohija. Read More

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Plasma calcitonin gene-related peptide (CGRP) in migraine and endometriosis during the menstrual cycle.

Ann Clin Transl Neurol 2021 May 2. Epub 2021 May 2.

Department of Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany.

Objective: Migraine, endometriosis, and the comorbidity of both are frequent pain disorders of special relevance for women. The neuropeptide calcitonin gene-related peptide (CGRP) is critically involved in migraine, and circumstantial evidence suggests a role in endometriosis. We assessed CGRP levels at different times of menstrual cycle in four groups: healthy women, women with migraine or endometriosis and with the comorbidity of both. Read More

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Perceived stress in the time of COVID-19: the association with brooding and COVID-related rumination in adults with and without migraine.

BMC Psychol 2021 Apr 30;9(1):68. Epub 2021 Apr 30.

SE-NAP2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary.

Background: The main goal of this research was to explore whether migraineurs had a higher level of perceived stress than healthy controls during the times of the coronavirus and related restrictive measures, and to examine the relationship between different subtypes of rumination and perceived stress in these groups. We measured two facets of depressive rumination, brooding and reflection, along with rumination about the current COVID-19 situation to see whether these different subtypes of rumination explained perceived stress among migraineurs and healthy controls.

Methods: Healthy adults (n = 64) and migraine patients (n = 73) filled out self-report questionnaires online. Read More

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[Betahistine in vestibular disorders: current concepts and perspectives].

Vestn Otorinolaringol 2021 ;86(2):73-81

Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency, Krasnoyarsk, Russia.

The goal of this paper is to review the pharmacological profile of betahistine and evidence for using it in the treatment of common vestibular disorders. Betahistine is a weak agonist for histamine H1 receptors and strong antagonist for histamine H3 receptors. It demonstrates the maximum benefit in different types of peripheral vertigo, especially in Meniere's disease. Read More

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Visual Aura in Migraine: An Analysis of 165 Patients in a Tertiary Care Hospital in North India.

J Neurosci Rural Pract 2021 Apr 3;12(2):273-280. Epub 2021 Mar 3.

Christian Medical College and Hospital, Ludhiana, Punjab, India.

 Migraine auras are transient neurological symptoms, usually lasting for approximately 5 to 30 minutes before the onset of migraine pain. Out of various types of auras, visual aura is the commonest and has variable manifestations, forming approximately 90% of auras. These visual auras may be of particular interest to the ophthalmologist as well as to the neurologist. Read More

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Neuro-Ophthalmology for Internists.

Med Clin North Am 2021 May;105(3):511-529

Department of Ophthalmology, University of Pennsylvania, 51 N 39th St, Philadelphia, PA 19104, USA.

Neuro-ophthalmology is the study of the neurologic underpinnings of vision and includes a fascinating variety of disorders that span the broad spectrum of ophthalmic and neurologic disease. This subspecialty relies heavily on accurate neuroanatomic localization and examination. This article discusses neuro-ophthalmic complaints that frequently present to the internist, including acute vision loss, double vision, and unequal pupils. Read More

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Social Distancing in Chronic Migraine during the COVID-19 Outbreak: Results from a Multicenter Observational Study.

Nutrients 2021 Apr 19;13(4). Epub 2021 Apr 19.

Department of Biomedicine, Neuroscience and Advanced Diagnostic (BIND), University of Palermo, 90127 Palermo, Italy.

Background: The restrictions taken to control the rapid spread of COVID-19 resulted in a sudden, unprecedented change in people's lifestyle, leading to negative consequences on general health. This study aimed to estimate the impact of such changes on migraine severity during 2020 March-May lockdown.

Methods: Patients affected by migraine with or without aura, diagnosed by expert physicians, completed a detailed interview comprehensive of: assessment of migraine characteristics; measure of physical activity (PA) levels; measure of the intake frequency of main Italian foods; the Insomnia Severity Index (ISI) questionnaire investigating sleep disorders. Read More

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Migraine and Mood in Children.

Parisa Gazerani

Behav Sci (Basel) 2021 Apr 14;11(4). Epub 2021 Apr 14.

Department of Life Sciences and Health, Faculty of Health Sciences, Oslo Metropolitan University, 0130 Oslo, Norway.

Migraine is one of the most prevalent headache disorders in children and negatively influences their quality of life. Physical, social, and school functioning are negatively affected. Mood changes are common in migraineurs and may happen before, during, or after a migraine headache. Read More

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Temporomandibular Disorders Slow Down the Regeneration Process of Masticatory Muscles: Transcriptomic Analysis.

Medicina (Kaunas) 2021 Apr 7;57(4). Epub 2021 Apr 7.

IRCCS Centro Neurolesi "Bonino-Pulejo", 98124 Messina, Italy.

Musculoskeletal injuries represent a pathological condition due to limited joint motility and morphological and functional alterations of the muscles. Temporomandibular disorders (TMDs) are pathological conditions due to alterations in the musculoskeletal system. TMDs mainly cause temporomandibular joint and masticatory muscle dysfunctions following trauma, along with various pathologies and inflammatory processes. Read More

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Hypoechogenicity of the midbrain raphe detected by transcranial sonography: an imaging biomarker for depression in migraine patients.

Ther Adv Neurol Disord 2021 12;14:17562864211007708. Epub 2021 Apr 12.

Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Centre of Vascular Ultrasonography, Beijing Institute of Brain Disorders, 45 Changchun Road, Xicheng District, Beijing, 100053, China.

Background: The high comorbidity of migraine and depression is suggestive of shared risk factors or common mechanisms between the two diseases. In individuals with a depressive disorder, there is a high prevalence of altered midbrain raphe (MBR) echogenicity, detectable transcranial sonography (TCS), that is suggested to be linked with a dysfunction of the serotoninergic system. In patients with migraine, this alteration has seldom been explored in earlier studies, and conclusions are often lacking. Read More

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Exploring the Hereditary Nature of Migraine.

Neuropsychiatr Dis Treat 2021 22;17:1183-1194. Epub 2021 Apr 22.

Queensland University of Technology (QUT), Centre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland, 4059, Australia.

Migraine is a common neurological disorder which affects 15-20% of the population; it has a high socioeconomic impact through treatment and loss of productivity. Current forms of diagnosis are primarily clinical and can be difficult owing to comorbidity and symptom overlap with other neurological disorders. As such, there is a need for better diagnostic tools in the form of genetic testing. Read More

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