30,855 results match your criteria Migraine Variants


Peripheral and central nervous system correlates in fibromyalgia.

Eur J Pain 2020 Jun 1. Epub 2020 Jun 1.

Applied Neurophysiology and Pain Unit, Department of Basic Medical Sciences Neurosciences and Sensory Organs, University of Bari "Aldo Moro", Bari, Italy.

Background: Fibromyalgia (FM) is a syndrome characterized by altered pain processing at central and peripheral level, whose pathophysiologic mechanisms remain obscure. We aimed at exploring the structural changes of peripheral nociceptor measured by skin biopsy, the functional changes of central nociceptive pathway assessed by laser evoked potentials (LEP), and their correlation with clinical features and comorbidities.

Methods: Eight-one patients diagnosed with FM underwent skin biopsies with quantification of intraepidermal nerve fiber density (IENFD) at the thigh and distal leg, and LEP recording by stimulating hand, thigh and foot. Read More

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http://dx.doi.org/10.1002/ejp.1607DOI Listing

Comparing the Effectiveness of Neurofeedback and Transcranial Direct Current Stimulation on Sleep Quality of Patients With Migraine.

Basic Clin Neurosci 2019 Nov-Dec;10(6):579-588. Epub 2019 Nov 1.

Department of Physiology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Introduction: Migraine is considered one of the most common primary headache disorders. Migraine attacks may occur due to a lack of sleep. Furthermore, sleep is regarded as one of the smoothing factors of migraine pain. Read More

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http://dx.doi.org/10.32598/BCN.10.6.651.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253802PMC
November 2019

Clinical Features and Burden Scores in Japanese Pediatric Migraines With Brainstem Aura, Hemiplegic Migraine, and Retinal Migraine.

J Child Neurol 2020 Jun 1:883073820927840. Epub 2020 Jun 1.

Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo, Japan.

Background: Migraines are a broad spectrum of disorders classified by the type of aura with some requiring attentive treatment. Vasoconstrictors, including triptans, should be avoided in the acute phase of migraines with brainstem aura, in hemiplegic migraine, and in retinal migraine. This study investigated the characteristics and burden of these migraines. Read More

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http://dx.doi.org/10.1177/0883073820927840DOI Listing

Fear, Avoidance, and Disability in Headache Disorders.

Curr Pain Headache Rep 2020 May 29;24(7):33. Epub 2020 May 29.

Department of Psychology, University of Mississippi, 207 Peabody, Oxford, MS, 38677, USA.

Purpose Of Review: The purpose of this review is to summarize the role of avoidance behavior in headache-related disability and overview relevant clinical implications.

Recent Findings: Avoidance occupies a central role in contemporary psychological perspectives on headache disorders and other chronic pain conditions. Several cognitive constructs of relevance to headache are influenced and maintained by avoidance behavior. Read More

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http://dx.doi.org/10.1007/s11916-020-00865-9DOI Listing

Functional NHE1 expression is critical to blood brain barrier integrity and sumatriptan blood to brain uptake.

PLoS One 2020 29;15(5):e0227463. Epub 2020 May 29.

Department of Pharmacology, University of Arizona, Tucson, Arizona, United States of America.

Disruption of blood-brain barrier integrity and dramatic failure of brain ion homeostasis including fluctuations of pH occurs during cortical spreading depression (CSD) events associated with several neurological disorders, including migraine with aura, traumatic brain injury and stroke. NHE1 is the primary regulator of pH in the central nervous system. The goal of the current study was to investigate the role of sodium-hydrogen exchanger type 1 (NHE1) in blood brain barrier (BBB) integrity during CSD events and the contributions of this antiporter on xenobiotic uptake. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227463PLOS

Functional gastrointestinal disorders in children: What is new?

J Paediatr Child Health 2020 May 29. Epub 2020 May 29.

Department of Gastroenterology, Joondalup Health Campus, Perth, Western Australia, Australia.

Abdominal pain-predominant functional gastrointestinal disorders encompass a group of chronic conditions featuring abdominal pain where no serious gastrointestinal or intra-abdominal pathology is present. The Rome IV classification system defines and categorises this group based on symptomatology as: functional dyspepsia, irritable bowel syndrome, functional abdominal pain - not otherwise specified and abdominal migraine. These conditions can impact the functioning of the child and family significantly and are challenging to manage. Read More

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http://dx.doi.org/10.1111/jpc.14857DOI Listing

Comprehensive Exonic Sequencing of Known Ataxia Genes in Episodic Ataxia.

Biomedicines 2020 May 25;8(5). Epub 2020 May 25.

Genomics Research Centre, Institute of Health and Biomedical Innovation (IHBI), School of Biomedical Sciences, Q Block, Queensland University of Technology (QUT), 60 Musk Ave, Kelvin Grove Campus, Brisbane, Queensland 4059, Australia.

Episodic Ataxias (EAs) are a small group (EA1-EA8) of complex neurological conditions that manifest as incidents of poor balance and coordination. Diagnostic testing cannot always find causative variants for the phenotype, however, and this along with the recently proposed EA type 9 (EA9), suggest that more EA genes are yet to be discovered. We previously identified disease-causing mutations in the gene in 48% ( = 15) of 31 patients with a suspected clinical diagnosis of EA2, and referred to our laboratory for gene testing, leaving 52% of these cases ( = 16) with no molecular diagnosis. Read More

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http://dx.doi.org/10.3390/biomedicines8050134DOI Listing

Monoclonal antibodies as a preventive therapy for migraine: A meta-analysis.

Clin Neurol Neurosurg 2020 May 11;195:105900. Epub 2020 May 11.

Dr Mohamad Amine Zbeib Polyclinic, Doha, Qatar.

Calcitonin gene-related peptide (CGRP) antagonists have recently grabbed the attention of clinicians for migraine prophylaxis. The present meta-analysis aimed to assess the efficacy and safety of CGRP monoclonal antibodies (mAbs) in patients with chronic and episodic migraine using a systematic therapeutic regimen. More specifically, double-blind placebo-controlled randomized clinical trials (RCTs) which assessed the therapeutic potential of monthly subcutaneous injections were included. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.105900DOI Listing

The current state of acute treatment for migraine in adults in the United States.

Postgrad Med 2020 May 27:1-9. Epub 2020 May 27.

University of Cincinnati, College of Medicine, Department of Internal Medicine , Cincinnati, OH, USA.

Migraine is a common and disabling disorder with substantial personal, social, and economic burden that affects 37 million people in the United States. Risk factors for migraine include age, sex, and genetics. The goal of acute treatment of migraine attacks is to stop the pain and associated symptoms of the migraine attack and return the patient to normal function. Read More

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http://dx.doi.org/10.1080/00325481.2020.1767402DOI Listing

Rare CACNA1A mutations leading to congenital ataxia.

Pflugers Arch 2020 May 26. Epub 2020 May 26.

Neuropediatric Department, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, 08950, Barcelona, Spain.

Human mutations in the CACNA1A gene that encodes the pore-forming α subunit of the voltage-gated Ca2.1 (P/Q-type) Ca channel cause multiple neurological disorders including sporadic and familial hemiplegic migraine, as well as cerebellar pathologies such as episodic ataxia, progressive ataxia, and early-onset cerebellar syndrome consistent with the definition of congenital ataxia (CA), with presentation before the age of 2 years. Such a pathological role is in accordance with the physiological relevance of Ca2. Read More

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http://dx.doi.org/10.1007/s00424-020-02396-zDOI Listing

Paracetamol versus Ibuprofen for the Acute Treatment of Migraine Headache in Children: A Blinded Randomized Controlled Trial.

Indian J Pediatr 2020 May 26. Epub 2020 May 26.

Neurology Clinic, Department of Pediatrics, Maulana Azad Medical College (University of Delhi) and associated Lok Nayak Hospital, 2, BSZ Marg, Delhi, 110002, India.

Objective: To compare the efficacy of oral paracetamol and oral ibuprofen for the management of acute headache in children with migraine without aura.

Methods: This randomized-controlled trial was done at the Pediatric department of a public hospital in India between 20 May, 2017 and 22 March, 2018, and enrolled children (aged 6-12 y) with Migraine without aura as per International Classification for Headache Disorders, 3rd edition (ICHD-3) criteria. The 50 patients (21 females, mean age 9. Read More

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http://dx.doi.org/10.1007/s12098-020-03315-xDOI Listing

The integration of multisensory motion stimuli is impaired in vestibular migraine patients.

J Neurol 2020 May 24. Epub 2020 May 24.

Department of Computer, Electric and Biomedical Engineering, University of Pavia, Via Ferrata, 5, 27100, Pavia, Italy.

Background: Vestibular migraine (VM) is a relatively recently acknowledged vestibular syndrome with a very relevant prevalence of about 10% among patients complaining of vertigo. The diagnostic criteria for VM have been recently published by the Bárány Society, and they are now included in the latest version of the International Classification of Headache Disorders, yet there is no instrumental test that supports the diagnosis of VM.

Objective: In the hypothesis that the integration of different vestibular stimuli is functionally impaired in VM, we tested whether the combination of abrupt vestibular stimuli and full-field, moving visual stimuli would challenge vestibular migraine patients more than controls and other non-vestibular migraineurs. Read More

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http://dx.doi.org/10.1007/s00415-020-09905-1DOI Listing

Persistent post-traumatic headache: a migrainous loop or not? The clinical evidence.

J Headache Pain 2020 May 24;21(1):55. Epub 2020 May 24.

Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Background: Headache is a common complication of traumatic brain injury. The International Headache Society defines post-traumatic headache as a secondary headache attributed to trauma or injury to the head that develops within seven days following trauma. Acute post-traumatic headache resolves after 3 months, but persistent post-traumatic headache usually lasts much longer and accounts for 4% of all secondary headache disorders. Read More

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http://dx.doi.org/10.1186/s10194-020-01122-5DOI Listing

Acrophobia and visual height intolerance: advances in epidemiology and mechanisms.

J Neurol 2020 May 22. Epub 2020 May 22.

German Center for Vertigo and Balance Disorders and Institute for Clinical Neurosciences, Ludwig Maximilians Universität, Marchioninistr. 15, 81377, Munich, Germany.

Historical descriptions of fear at heights date back to Chinese and Roman antiquity. Current definitions distinguish between three different states of responses to height exposure: a physiological height imbalance that results from an impaired visual control of balance, a more or less distressing visual height intolerance, and acrophobia at the severest end of the spectrum. Epidemiological studies revealed a lifetime prevalence of visual height intolerance including acrophobia in 28% of adults (32% in women; 25% in men) and 34% among prepubertal children aged 8-10 years without gender preponderance. Read More

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http://dx.doi.org/10.1007/s00415-020-09805-4DOI Listing

Evaluation and Treatment of Primary Headaches in Adolescents.

Prim Care 2020 Jun 20;47(2):241-256. Epub 2020 Feb 20.

Department of Emergency Medicine, WVU Medicine, West Virginia University, 1 Medical Center Drive, Morgantown, WV, 26505, USA.

Headache is a common episodic and chronic pain syndrome in adolescents. Evaluation of headaches in primary care requires a comprehensive assessment including lifestyle behaviors and physical examination, as well as an understanding of when to pursue appropriate testing. Primary headache disorders seen in adolescents include migraine and tension-type headache. Read More

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http://dx.doi.org/10.1016/j.pop.2020.02.004DOI Listing

Migraine, Human Genetics and a Passion for Science.

Authors:
Dale R Nyholt

Twin Res Hum Genet 2020 May 19:1-2. Epub 2020 May 19.

School of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.

This note reflects on my collaborations with Nick Martin and the GenEpi group over the past 20 years. Over the past two decades, our work together has focused on gene mapping and understanding the genetic architecture of a wide range of traits with particular foci on migraine and common baldness. Our migraine research has included latent class and twin analyses cumulating in genome-wide association analyses which had identified 44 (34 new) risk variants for migraine. Read More

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http://dx.doi.org/10.1017/thg.2020.22DOI Listing

Neck-specific strengthening exercise compared with sham ultrasound when added to home-stretching exercise in patients with migraine: study protocol of a two-armed, parallel-groups randomized controlled trial.

Chiropr Man Therap 2020 May 19;28(1):22. Epub 2020 May 19.

Department of Health Sciences - Ribeirão Preto Medical School, University of São Paulo, 3900, Bandeirantes Avenue - Monte Alegre, Ribeirão Preto, SP, 14049-900, Brazil.

Background: Migraine is a highly disabling condition and pharmacological treatment is the gold standard. However, several patients have also positive responses to the application of different manual techniques and therapeutic exercises in terms of reducing the intensity and frequency of migraine attacks. Nevertheless, the effects of a neck-specific exercise program have not yet been evaluated in these patients. Read More

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http://dx.doi.org/10.1186/s12998-020-00313-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236100PMC

Contextual sensory integration training via head mounted display for individuals with vestibular disorders: a feasibility study.

Disabil Rehabil Assist Technol 2020 May 18:1-11. Epub 2020 May 18.

Vestibular Rehabilitation, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA.

Virtual reality (VR) interventions can simulate real-world sensory environments. The purpose of this study was to test the feasibility of a novel VR application (app) developed for a Head Mounted Display (HMD) to target dizziness, imbalance and sensory integration in a functional context for patients with vestibular disorders. Here we describe the design of the app as well as self-reported and functional outcomes in vestibular patients before and after participating in vestibular rehabilitation using the app. Read More

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http://dx.doi.org/10.1080/17483107.2020.1765419DOI Listing

Effect of probiotic supplementation on migraine prophylaxis: a systematic review and meta-analysis of randomized controlled trials.

Nutr Neurosci 2020 May 18:1-8. Epub 2020 May 18.

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

The prevalence of migraine is higher in patients with gastrointestinal disorders. Possible underlying mechanisms could be increased intestinal permeability and systemic inflammation. Probiotics may reduce gut permeability as well as inflammation, and therefore may improve the clinical features of migraine. Read More

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http://dx.doi.org/10.1080/1028415X.2020.1764292DOI Listing

The Combination Of Rtms And Pharmacotherapy On In Vitro Models: A Mini Review.

CNS Neurol Disord Drug Targets 2020 May 17. Epub 2020 May 17.

Laboratory of Clinical Neurophysiology, AHEPA University Hospital, Aristotle University of Thessaloniki, 54006, Thessaloniki. Greece.

Background: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique which is being actively explored as a potential therapeutic modality in various neuropsychiatric disorders, such as depression, neuropathic pain, epilepsy, multiple sclerosis and neurodegenerative disorders, including Parkinson's and Alzheimer's disease. The Food and Drug Administration (FDA) approved rTMS for the treatment of major depression, migraine associated headaches and obsessive compulsive disorder (OCD). The fact that a significant proportion of patients suffering from these disorders fail to respond to current pharmacological interventions, indicates the need for alternative therapies like rTMS. Read More

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http://dx.doi.org/10.2174/1871527319666200518100716DOI Listing

Associations between migraine, celiac disease, non-celiac gluten sensitivity and activity of diamine oxidase.

Med Hypotheses 2020 Apr 11;142:109738. Epub 2020 Apr 11.

Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Eivenių g. 2, Kaunas, Lithuania.

Background And Pilot Study: Recent reports reveal a close relationship between migraine and gastrointestinal disorders (GI), such as celiac disease (CD) and non-celiac gluten sensitivity (NCGS). CD is a genetic autoimmune disorder, which affects the mucosa of the small intestine. Gluten, found in various grains, not only plays a major role in the pathophysiology of CD and NCGS, but also aggravates migraine attacks. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109738DOI Listing

A Novel Heterozygous Variant in Exon 19 of NOTCH3 in a Saudi Family with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy.

J Stroke Cerebrovasc Dis 2020 May 12:104832. Epub 2020 May 12.

Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL; OMIM #125310) is the most common cause of monogenic familial cerebral small vessel disease. It typically manifests at middle adulthood with highly variable clinical features including migraine with aura, recurrent transient ischemic attacks or ischemic strokes, mood disorders, and progressive cognitive decline. It is caused by mutations in the NOTCH3 gene, which maps to the short arm of chromosome 19 and encode for epidermal growth factor-like repeats. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2020.104832DOI Listing

Critical Review of Transcutaneous Vagus Nerve Stimulation: Challenges for Translation to Clinical Practice.

Front Neurosci 2020 28;14:284. Epub 2020 Apr 28.

Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, VIC, Australia.

Several studies have illustrated that transcutaneous vagus nerve stimulation (tVNS) can elicit therapeutic effects that are similar to those produced by its invasive counterpart, vagus nerve stimulation (VNS). VNS is an FDA-approved therapy for the treatment of both depression and epilepsy, but it is limited to the management of more severe, intervention-resistant cases as a second or third-line treatment option due to perioperative risks involved with device implantation. In contrast, tVNS is a non-invasive technique that involves the application of electrical currents through surface electrodes at select locations, most commonly targeting the auricular branch of the vagus nerve (ABVN) and the cervical branch of the vagus nerve in the neck. Read More

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http://dx.doi.org/10.3389/fnins.2020.00284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199464PMC

ATTACHMENT STYLE IN CHILDREN WITH CHRONIC DISEASES: A COMPREHENSIVE REVIEW.

Rev Paul Pediatr 2020 8;38:e2018308. Epub 2020 May 8.

Universidade Federal de Pernambuco, Recife, PE, Brazil.

Objective: To investigate how attachment style has been studied in children with chronic disease in the scientific literature, and what repercussions this attachment has on this population.

Data Sources: An integrative review of the literature was carried out from a survey in the LILACS, MEDLINE and SciELO databases, including original national and international publications in Portuguese, Spanish and English from 2007 to 2018, using the descriptors "apego" and "criança" in the Health Sciences Descriptors (DeCS), and "attachment" and "children" for the Medical Subject Headings (MeSH). Sixteen (16 articles) were obtained for the sample analysis. Read More

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http://dx.doi.org/10.1590/1984-0462/2020/38/2018308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212585PMC

The enigma of headaches associated with electromagnetic hyperfrequencies: Hypotheses supporting non-psychogenic algogenic processes.

Authors:
D H Toffa A D Sow

Electromagn Biol Med 2020 May 13:1-10. Epub 2020 May 13.

Division of Neurology, CHUN Fann, Université Cheikh Anta Diop, Dakar, Senegal.

Although an electrohypersensitivity (EHS) is reported in numerous studies, some authors associate hyperfrequencies (HF)-related pains with a nocebo effect while others suggest a biological effect. Therefore, we aimed to suggest hypotheses about the complex mechanisms of headaches related to HF-exposure. We crossed basic features of headaches with relevant studies (from the year 2000 up to 2018) emphasizing on the HF effects that may lead to pain genesis: neuroglial dysmetabolism, neuroinflammation, changes in cerebral blood perfusion, blood-brain barrier dysfunction and electrophysiological evidences of hyperexcitability. Read More

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http://dx.doi.org/10.1080/15368378.2020.1762638DOI Listing

Cluster headache in Asian populations: Similarities, disparities, and a narrative review of the mechanisms of the chronic subtype.

Cephalalgia 2020 May 12:333102420923646. Epub 2020 May 12.

Department of Neurology, Neuroscience Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Objective: Headache disorders like migraine show geographic and ethnic differences between Asian and European/North American countries. In cluster headache, these differences are rarely mentioned and discussed. This article aimed to review the characteristics of cluster headache in Asian countries and compare the clinical features to those in European and North American populations. Read More

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http://dx.doi.org/10.1177/0333102420923646DOI Listing

Lost productivity associated with headache and depression: a quality improvement project identifying a patient population at risk.

J Headache Pain 2020 May 11;21(1):50. Epub 2020 May 11.

Walter Reed National Military Medical Center, Neurology Department, 8901 Rockville Pike, Bethesda, MD, 20889, USA.

Objective: This quality improvement project was implemented in order to highlight the association between headache, mTBI and depression on lost productivity and resource utilization.

Background: Mood disorders, environment and traumatic brain injury are common in patients with headache, and have been shown to influence clinical course, treatment response and outcome. Although widely recognized, the association of these factors on clinical outcomes, resource utilization and productivity is not well understood. Read More

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http://dx.doi.org/10.1186/s10194-020-01107-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216618PMC

Long-Term Effect of Acupuncture on the Medical Expenditure and Risk of Depression and Anxiety in Migraine Patients: A Retrospective Cohort Study.

Front Neurol 2020 24;11:321. Epub 2020 Apr 24.

Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.

Migraine, a common neurological disorder, increases the risk of psychiatric disorders. Currently, the efficacy of conventional therapies is considered unsatisfactory. Acupuncture has been gaining popularity in treatment of neuropsychiatric disease. Read More

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http://dx.doi.org/10.3389/fneur.2020.00321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193015PMC

Sex differences in acute ischemic stroke patients: clinical presentation, causes and outcomes.

Eur J Neurol 2020 May 8. Epub 2020 May 8.

From the Stroke Center, Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital, Lausanne, Switzerland.

Background: To investigate sex differences in causes, clinical presentation, outcome and stroke recurrences in a large cohort of consecutive acute ischemic stroke (AIS) patients.

Methods: Patients from the Acute STroke Registry and Analysis of Lausanne were included from 03/2003-04/2016. Multivariate analysis of clinical, pathophysiological and biological variables was conducted. Read More

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http://dx.doi.org/10.1111/ene.14299DOI Listing

Efficacy of adjunctive infliximab vs. placebo in the treatment of anhedonia in bipolar I/II depression.

Brain Behav Immun 2020 May 4. Epub 2020 May 4.

Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada; Brain and Cognition Discovery Foundation, Toronto, ON, Canada. Electronic address:

We investigated the efficacy of tumour necrosis factor (TNF)-α antagonist infliximab on a measure of anhedonia amongst individuals with bipolar I/II depression (ClinicalTrials.gov identifier NCT02363738). Adults (ages 18-65) with bipolar I/II disorder currently experiencing a major depressive episode with a higher probability of inflammatory activity (i. Read More

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http://dx.doi.org/10.1016/j.bbi.2020.04.063DOI Listing
May 2020
5.889 Impact Factor

Non-invasive assessment of endothelial function in patients with spontaneous coronary artery dissection: A case-control study.

Int J Cardiol 2020 May 4. Epub 2020 May 4.

Hospital Clínico San Carlos, IdISSC and Universidad Complutense, Madrid, Spain.

Background: The physiopathology underlying spontaneous coronary artery dissection remains largely unknown. Endothelial dysfunction is an early feature of many vascular disorders. We sought to determine the endothelial function assessed by reactive hyperemia peripheral arterial tonometry (RH-PAT) in patients with SCAD and compare it to that of non-SCAD patients with similar cardiovascular risk profile. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.04.049DOI Listing

Polygenic risk scores indicates genetic overlap between peripheral pain syndromes and chronic postsurgical pain.

Neurogenetics 2020 May 6. Epub 2020 May 6.

Department of Anaesthesiology and Pain Management, Maastricht University Medical Center+, 6200, MD, Maastricht, The Netherlands.

Chronic postsurgical pain (CPSP) is a debilitating chronic pain condition that has a substantial effect on quality of life. CPSP shows considerable clinical overlap with different chronic peripheral pain syndromes, suggesting a shared aetiology. This study aims to assess the genetic overlap between different chronic pain syndromes and CPSP, providing relevant biological context for potential chronic pain markers of CPSP. Read More

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http://dx.doi.org/10.1007/s10048-020-00614-5DOI Listing

Disrupted functional connectivity between sub-regions in the sensorimotor areas and cortex in migraine without aura.

J Headache Pain 2020 May 6;21(1):47. Epub 2020 May 6.

Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Electronic Science, East China Normal University, 3663 North Zhong-Shan Road, 200062, Shanghai, People's Republic of China.

Background: Migraine is a severe and disabling brain disorder, and the exact neurological mechanisms remain unclear. Migraineurs have altered pain perception, and headache attacks disrupt their sensory information processing and sensorimotor integration. The altered functional connectivity of sub-regions of sensorimotor brain areas with other brain cortex associated with migraine needs further investigation. Read More

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http://dx.doi.org/10.1186/s10194-020-01118-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203097PMC

Evaluation of anxiety, depression and marital relationships in patients with migraine.

Ideggyogy Sz 2020 Mar;73(3-4):129-134

Psychiatry Department of Istanbul Yeni Yüzyıl University School of Medicine, Istanbul 34245, Turkey.

Background And Purpose: The aim of this study was to evaluate the frequency and characteristics of attacks in patients with migraine, to determine the effects of anxiety or depressive symptoms, and to evaluate the marital relationships of patients with migraine.

Methods: Thirty patients who were admitted to the neurology outpatient clinic of our hospital between July 2018 and October 2018 and were diagnosed with migraine according to the 2013 International Headache Society (IHS) diagnostic criteria were included in this cross-sectional study. Age, sex, headache frequency and severity, depressive traits, marital satisfaction and anxiety status were examined. Read More

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http://dx.doi.org/10.18071/isz.73.0129DOI Listing

Expanding Clinical Indications of Mechanically Isolated Stromal Vascular Fraction: A Systematic Review.

Aesthet Surg J 2020 May 2. Epub 2020 May 2.

Background: Mechanically isolated stromal vascular fraction (tSVF, tissue SVF) is a potent regenerative solution, increasingly used as a therapeutic modality for a variety of pathologies. With recent evidence conclusively favoring mechanical isolation over enzymatic alternatives, the therapeutic share and indications of tSVF are expected to grow even further.

Objectives: To provide a systematic review of all studies reporting on the use of tSVF. Read More

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http://dx.doi.org/10.1093/asj/sjaa111DOI Listing

Bilateral stellate ganglion block for migraine: A case report.

Medicine (Baltimore) 2020 May;99(18):e20023

Department of Anesthesiology and Pain Medicine, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.

Rationale: Migraine is a recurrent, disabling neurovascular headache disorder. The patient's quality of life can be severely impaired by migraine attacks. Stellate ganglion block (SGB) can be used to relieve pain in the head, neck, and upper extremities. Read More

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http://dx.doi.org/10.1097/MD.0000000000020023DOI Listing

Cold extremities in migraine: a marker for vascular dysfunction in women.

Eur J Neurol 2020 Apr 30. Epub 2020 Apr 30.

Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Background And Purpose: Migraine is recognized as a vascular risk factor, especially in women. Presumably, migraine, stroke and cardiovascular events share pathophysiological mechanisms. Self-reported cold extremities were investigated as a marker for vascular dysfunction in migraine. Read More

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http://dx.doi.org/10.1111/ene.14289DOI Listing

Evidence of new-onset depression among persons with migraine after discontinuing antidepressants.

Psychiatry Res 2020 Jun 10;288:112990. Epub 2020 Apr 10.

Department of Psychiatry, University of Utah, Salt Lake City, Utah, United States.

Antidepressants have been hypothesized to cause tardive dysphoria-the delayed development of negative emotional symptoms. We assessed the risk of tardive dysphoria in a cohort of persons with migraine taking anti-migraine antidepressants with no known diagnosis of any mood or anxiety disorder. We included all outpatient encounters in a university hospital system for migraine from January 2008 through October 2018, excluding subjects with prior psychiatric diagnoses. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.112990DOI Listing

Endogenous Melatonin Levels and Therapeutic Use of Exogenous Melatonin in Migraine: Systematic Review and Meta-Analysis.

Headache 2020 Apr 30. Epub 2020 Apr 30.

Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, Larissa, Greece.

Background: Sleep disorders and circadian dysregulation appear to be associated with primary headache disorders.

Objective: The aim of this study was to review the existing evidence for the deployment of melatonin in migraine prophylaxis. Initially, case-control studies investigating nocturnal melatonin and 6-sulphatoxymelatonin (aMT6s, melatonin metabolite discarded by the urine) levels in patients with migraine and healthy controls (HC) would be reviewed and meta-analyzed. Read More

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http://dx.doi.org/10.1111/head.13828DOI Listing

Migraine screen questionnaire: further psychometric evidence from categorical data methods.

Health Qual Life Outcomes 2020 Apr 28;18(1):113. Epub 2020 Apr 28.

The University Sleep Disorders Center, College of Medicine, King Saud University, Box 225503, Riyadh, 11324, Saudi Arabia.

Background: Psychometric investigations of tools used in the screening of migraine including the migraine screen questionnaire (MS-Q), using an adequate statistical approach is needed. We assessed the psychometric properties of the migraine screen questionnaire (MS-Q) using categorical data methods.

Material And Methods: A total of 343 students at Mizan-Tepi University, Ethiopia, age range = 18-35 years were selected by a simple random sampling method to participate in a cross-sectional study. Read More

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http://dx.doi.org/10.1186/s12955-020-01361-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189686PMC

Vancouver Declaration II on Global Headache Patient Advocacy 2019.

Cephalalgia 2020 Apr 28:333102420921162. Epub 2020 Apr 28.

Lund University Hospital, Lund, Sweden.

In 2017, the International Headache Society convened a Global Patient Advocacy Summit (GPAS-1) to begin a collaborative effort involving patients, patient advocates, patient advocacy organizations, healthcare professionals, scientists, professional pain, neurology, and headache societies, pharmaceutical manufacturers, and regulatory agencies to advance issues of importance to patients affected by headache worldwide. In September 2019, the second Global Patient Advocacy Summit (GPAS-2) was convened to revisit issues from the inaugural meeting, assess the progress of the International Headache Society Global Patient Advocacy Coalition (IHS-GPAC) in meeting the goals set forth therein, and discuss strategies for achieving established goals and supporting future development. Short- and long-term mandates from the first Summit were realized, including publishing the Vancouver Declaration on Global Headache Patient Advocacy 2018, determining the governing and operational structures of the IHS-GPAC, and helping to facilitate the first World Federation of Neurology World Brain Day dedicated to migraine. Read More

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http://dx.doi.org/10.1177/0333102420921162DOI Listing

The Role of Polysomnography in Identifying Sleep Disorders in Children with Migraine.

J Med Life 2020 Jan-Mar;13(1):64-67

Clinical Neurosciences Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Migraine pathophysiology and sleep share common neural pathways, and there are clinical as well as paraclinical observations, which lead to the hypothesis of an association between migraine and sleep disorders. The objective of this study consisted of the evaluation of a possible correlation between migraine and sleep disorders in children, as reflected by sleep architecture and electroencephalographic patterns. Eighteen patients aged five to seventeen were recruited for the migraine group, and sixteen age-matched patients with no criteria for migraine or any underlying organic disorder, diagnosed with emotional disorders, were enrolled in the control group. Read More

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http://dx.doi.org/10.25122/jml-2020-0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175440PMC

Clinical presentation of Y189C mutation of the NOTCH3 gene in the Polish family with CADASIL.

Folia Neuropathol 2020 ;58(1):83-92

Chair and Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland.

Introduction: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary, progressive ischemic disease of small vessels of the brain characterized by migraine with aura (MA), recurrent subcortical ischemic episodes, cognitive decline and psychiatric disorders. CADASIL is caused by mutations in the NOTCH3 gene. We identified the NOTCH3 Y189C mutation as a genetic cause of CADASIL in a Polish family and provided its first clinical manifestation. Read More

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http://dx.doi.org/10.5114/fn.2020.94009DOI Listing
January 2020

The Value of Headache-Specific Recommendations During COVID-19.

Headache 2020 05;60(5):820-823

Comprehensive Headache Program, Department of Neurology, Wake Forest Baptist Health, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1111/head.13821DOI Listing

Two distinct phenotypes, hemiplegic migraine and episodic Ataxia type 2, caused by a novel common CACNA1A variant.

BMC Neurol 2020 Apr 26;20(1):155. Epub 2020 Apr 26.

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialities, Specialities "G. D'Alessandro," University of Palermo, Palermo, Italy.

Background: To investigate the genetic and environmental factors responsible for phenotype variability in a family carrying a novel CACNA1A missense mutation. Mutations in the CACNA1A gene were identified as responsible for at least three autosomal dominant disorders: FHM1 (Familial Hemiplegic Migraine), EA2 (Episodic Ataxia type 2), and SCA6 (Spinocerebellar Ataxia type 6). Overlapping clinical features within individuals of some families sharing the same CACNA1A mutation are not infrequent. Read More

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http://dx.doi.org/10.1186/s12883-020-01704-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183684PMC

Psychiatric Comorbidities in Patients with Migraine in a Tertiary Hospital.

J Nepal Health Res Counc 2020 Apr 20;18(1):82-87. Epub 2020 Apr 20.

Department of Psychiatry, Manipal College of Medical Sciences, Pokhara, Nepal.

Background: Psychiatric disorders are common in the migraine patients and affect the quality of the life of the individual. The objective of the study was to study the different psychiatric comorbidities and its relationship in migraine patients.

Methods: This was hospital based cross-sectional study. Read More

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http://dx.doi.org/10.33314/jnhrc.v18i1.2202DOI Listing

Effects on migraine, neck pain, and head and neck posture, of temporomandibular disorder treatment: Study of a retrospective cohort.

Authors:
Jeong-Hyun Kang

Arch Oral Biol 2020 Jun 18;114:104718. Epub 2020 Apr 18.

Clinic of Oral Medicine and Orofacial Pain, Institute of Oral Health Science, Ajou University School of Medicine, 164, Worldcup-ro, Yeongtong-gu, Suwon, Gyeonggi-do, 16499, Republic of Korea. Electronic address:

Objectives: The present study purposed to observe the response of comorbidities of temporomandibular disorders (TMD) including migraine and cervical dysfunction after painful TMD treatment.

Design: A total of 187 patients were included: 45 had no symptoms related to the painful TMD and migraine (Control), 52 had the painful TMD only (pTMD), 47 had the painful TMD that occurred earlier than the migraine (TMD1ST), and 43 had the migraine that occurred earlier than the painful TMD (MIG1ST). All patients were diagnosed based on the Research Diagnostic Criteria for Temporomandibular Disorders and International Classification of Headache Disorders, 3rd edition. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104718DOI Listing

Utriculo-ocular pathway dysfunction is more frequent in vestibular migraine than probable vestibular migraine.

J Neurol 2020 Apr 24. Epub 2020 Apr 24.

Department of Otolaryngology and Head and Neck Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Abnormal vestibular function has been reported in patients with vestibular migraine (VM). However, it is unclear whether the proportion of patients with vestibular dysfunction differs between the diagnoses of VM and probable VM (PVM).

Methods: We reviewed the medical records of 1736 patients who underwent cervical vestibular-evoked myogenic potential testing to air-conducted sound (ACS cVEMP), ocular VEMP testing to bone-conducted vibration (BCV oVEMP), and caloric testing. Read More

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http://dx.doi.org/10.1007/s00415-020-09851-yDOI Listing

Transcranial Direct Current Stimulation and Migraine-The Beginning of a Long Journey.

J Clin Med 2020 Apr 22;9(4). Epub 2020 Apr 22.

EA 4391, Excitabilité Nerveuse et Thérapeutique, Université Paris-Est-Créteil, 94010 Créteil, France.

Migraine, a benign yet disturbing condition, is one of the frequent neurological disorders, affecting up to 15-20% of the worldwide population [... Read More

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http://dx.doi.org/10.3390/jcm9041194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230683PMC