38,947 results match your criteria Migraine Headache Neuro-ophthalmic Perspective


Assessment of the Progression of Vertical Semicircular Canal Dysfunction and Increased Vestibular Endolymphatic Hydrops in Patients With Early-Stage Ménière Disease.

JAMA Otolaryngol Head Neck Surg 2020 Jul 9. Epub 2020 Jul 9.

Department of Otolaryngology, University of Tokushima School of Medicine, Tokushima, Japan.

Importance: Vertical semicircular canals and endolymphatic hydrops play important roles in the pathophysiological mechanisms of Ménière disease. However, their characteristics and associations with disease progression during medical treatment have not been determined.

Objective: To examine the function of both the horizontal and vertical semicircular canals in patients with Ménière disease and to evaluate the change in endolymphatic hydrops volume during medical treatment, including treatment with diuretic therapy, over a 2-year period. Read More

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http://dx.doi.org/10.1001/jamaoto.2020.1496DOI Listing

Estimating the Savings of a Migraine Free Life: Results from the Spanish Atlas.

Eur J Neurol 2020 Jul 9. Epub 2020 Jul 9.

Headache Unit, Neurology Department, Vall d'Hebron University Hospital & Headache Research Group, VHIR, Universitat Autónoma de Barcelona, Member of the Headache Study Group of the Spanish Neurological Society (GECSEN), Barcelona, Spain.

Background: Migraine is a common and costly neurological disorder. The aim of this study was to quantify the costs of chronic (CM) and episodic migraine (EM) in Spain, evaluating the impact of psychiatric comorbidities and disability, and estimate the economic savings of reducing the number of migraine days by 50%.

Methods: This was an observational, cross-sectional analysis of data from migraine patients who participated in the Spanish Migraine Atlas. Read More

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http://dx.doi.org/10.1111/ene.14431DOI Listing

Transient Global Amnesia - Risk Factors and Putative Background.

Neurol India 2020 May-Jun;68(3):624-629

Department of Neurology, Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland.

Objectives: Transient global amnesia (TGA) is a temporary short-term reversible memory loss. Etiology of TGA remains unclear with various hypotheses. We analyzed clinical characteristics, neuroimaging, and electrophysiological findings as well as comorbidities and seasonal variation in TGA patients with regard to possible background of the syndrome. Read More

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http://dx.doi.org/10.4103/0028-3886.288979DOI Listing

Validity of the Patient Health Questionnaire-9 in neurologic populations.

Neurol Clin Pract 2020 Jun 13;10(3):190-198. Epub 2020 Apr 13.

Department of Psychiatry (KGW, SBP) and Department of Community Health Sciences (MS, SBP), Cumming School of Medicine, University of Calgary, Alberta, Canada; and Department of Neurology (NJ), Icahn School of Medicine at Mount Sinai, New York.

Background: Because of symptom overlap, there is uncertainty about the validity of depression rating scales in neurologic populations. The objectives of this study were to evaluate the validity of the Patient Health Questionnaire-9 (PHQ-9) for detecting Diagnostic and Statistical Manual-defined major depressive episodes in people with neurologic conditions.

Methods: Participants were recruited from outpatient clinics for multiple sclerosis, epilepsy, migraine, Parkinson disease, and stroke for this cross-sectional study. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292563PMC

Teaching NeuroImages: Transient Cytotoxic Edema in a Child with a Novel ATP1A2 Mutation.

Neurology 2020 Jul 8. Epub 2020 Jul 8.

Melissa G. Chung, MD Department of Neurology, Nationwide Children's Hospital 700 Children's Drive, Columbus, OH, 43205-2664 Phone: 614-722-4625 Fax: 614-722-4633 Email:

A seven-year-old boy with prior episodes of hemiplegia and family history of hemiplegic migraine presented with fevers, waxing and waning encephalopathy (lethargic and poorly interactive), and left-sided weakness persistent throughout his five-week hospitalization. Diagnostic testing revealed a suspected pathogenic mutation in (c.2285G>C; p. Read More

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http://dx.doi.org/10.1212/WNL.0000000000010103DOI Listing

TRESK and TREK-2 two pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons.

J Biol Chem 2020 Jul 7. Epub 2020 Jul 7.

Semmelweis University.

Two-pore domain potassium channels (K2P) are the major determinants of the background potassium conductance. They play a crucial role in setting the resting membrane potential and regulating cellular excitability.  These channels form homodimers, however, a few examples of heterodimerization have also been reported. Read More

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http://dx.doi.org/10.1074/jbc.RA120.014125DOI Listing

Factors associated with insufficient response to acute treatment of migraine in Japan: analysis of real-world data from the Adelphi Migraine Disease Specific Programme.

BMC Neurol 2020 Jul 8;20(1):274. Epub 2020 Jul 8.

Lilly Hungária Kft, Budapest, Hungary.

Background: Real-world data on sufficient/insufficient response, and predictors of insufficient response, to acute treatments for migraine are limited in Japan. This study aimed to identify factors associated with insufficient response to acute treatment of migraine by exploring significant differences between people with migraine who sufficiently/insufficiently respond to prescribed acute treatment in Japan.

Methods: This was a retrospective analysis of 2014 Adelphi Migraine Disease Specific Programme cross-sectional survey data collected from physicians and their consulting adult patients with migraine in Japan. Read More

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http://dx.doi.org/10.1186/s12883-020-01848-4DOI Listing

Migraine, attention deficit hyperactivity disorder and screen time in children attending a Sri Lankan tertiary care facility: are they associated?

BMC Neurol 2020 Jul 8;20(1):275. Epub 2020 Jul 8.

Department of Community Medicine, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.

Background: Headache and Attention Deficit Hyperactivity Disorder (ADHD) are two relatively common, neuropsychiatric conditions seen in children. Recent studies have shown an association between these two disorders, which are otherwise distinct conditions. This study aims to assess the association between migraine and ADHD, as well as the association between screen-time and these two conditions, among children attending a Sri Lankan tertiary care facility. Read More

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http://dx.doi.org/10.1186/s12883-020-01855-5DOI Listing

Neuropeptide FF receptor 2 inhibits capsaicin-induced CGRP Upregulation in mouse trigeminal ganglion.

J Headache Pain 2020 Jul 8;21(1):87. Epub 2020 Jul 8.

Graduate Institute of Biomedical Sciences, Department of Physiology and Pharmacology, Chang Gung University, 259 Wenhua 1st Road, Guishan Dist, Taoyuan City, 33302, Taiwan.

Background: Stimulation of trigeminovascular pathway is widely used to establish the headache animal model. Headache is a common neurological disorder, in which symptomatic attacks are mediated by calcitonin-gene-related peptide (CGRP). CGRP is synthesized and released from the trigeminal ganglion to transmit pain signals under stimulation. Read More

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http://dx.doi.org/10.1186/s10194-020-01152-zDOI Listing

Peri-Infarct Hot-Zones Have Higher Susceptibility to Optogenetic Functional Activation-Induced Spreading Depolarizations.

Stroke 2020 Jul 9:STROKEAHA120029618. Epub 2020 Jul 9.

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston. (K.S., D.Y.C., M.B., P.F., T.T., S.A.A., T.Q., T.Y., F.O., C.A.).

Background And Purpose: Spreading depolarizations (SDs) are recurrent and ostensibly spontaneous depolarization waves that may contribute to infarct progression after stroke. Somatosensory activation of the metastable peri-infarct tissue triggers peri-infarct SDs at a high rate.

Methods: We directly measured the functional activation threshold to trigger SDs in peri-infarct hot zones using optogenetic stimulation after distal middle cerebral artery occlusion in Thy1-ChR2-YFP mice. Read More

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http://dx.doi.org/10.1161/STROKEAHA.120.029618DOI Listing

Receptor mechanisms mediating the anti-neuroinflammatory effects of endocannabinoid system modulation in a rat model of migraine.

Eur J Neurosci 2020 Jul 8. Epub 2020 Jul 8.

Abant Izzet Baysal University, Medical Faculty, Department of Neurosurgery, Bolu, Turkey.

Calcitonin gene-related peptide (CGRP), substance-P and dural mast cells are main contributors in neurogenic inflammation underlying migraine pathophysiology. Modulation of endocannabinoid system attenuates migraine pain, but its mechanisms of action remains unclear. We investigated receptor mechanisms mediating anti-neuroinflammatory effects of endocannabinoid system modulation in in-vivo migraine model and ex-vivo hemiskull preparations in rats. Read More

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http://dx.doi.org/10.1111/ejn.14897DOI Listing

Foreign accent syndrome and psychosis: a case report.

Authors:
M Asghar P Whitty

Ir J Psychol Med 2020 Jun 3;37(2):118-121. Epub 2017 Jul 3.

Department of Psychiatry Acute Psychiatric Unit, Tallaght Hospital, Dublin, Ireland.

This is a case report on a 57-year-old lady who presented to the Psychiatry Department of Tallaght Hospital after being referred by Neurology Department. She was initially attending Neurology Department for idiopathic Parkinson's disease which was later refuted as there was no objective evidence of response to treatment. She attended the A&E department with altered consciousness and headache, but her computed tomography of the brain was normal, and was diagnosed with migraine. Read More

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http://dx.doi.org/10.1017/ipm.2017.12DOI Listing

Effect of cinnamon on migraine attacks and inflammatory markers: A randomized double-blind placebo-controlled trial.

Phytother Res 2020 Jul 7. Epub 2020 Jul 7.

Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Migraine is the most common type of primary headaches. Increased levels of interleukin-6 (IL-6), calcitonin-gene-related peptide (CGRP) and nitric oxide (NO) lead to inflammation and neurogenic pain. Cinnamon has anti-inflammatory and neuroprotective properties. Read More

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http://dx.doi.org/10.1002/ptr.6721DOI Listing

Intravenous Migraine Treatment in Children and Adolescents.

Curr Pain Headache Rep 2020 Jul 8;24(8):45. Epub 2020 Jul 8.

Division of Neurology, Cincinnati Children's Hospital Medical Center/University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.

Purpose Of Review: Pediatric migraine is a common, chronic, and disabling neurological disorder in children and adolescents. Outpatient management is not always effective, and intravenous migraine management may be necessary for headache treatment in the pediatric emergency department. Most current treatment is based on retrospective evidence and there is a lack of well-designed randomized double-blinded controlled pediatric studies. Read More

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http://dx.doi.org/10.1007/s11916-020-00867-7DOI Listing

Machine learning approach to predict medication overuse in migraine patients.

Comput Struct Biotechnol J 2020 12;18:1487-1496. Epub 2020 Jun 12.

BioBIM (InterInstitutional Multidisciplinary Biobank), IRCCS San Raffaele Pisana, Via di Val Cannuta 247, 00166 Rome, Italy.

Machine learning (ML) is largely used to develop automatic predictors in migraine classification but automatic predictors for medication overuse (MO) in migraine are still in their infancy. Thus, to understand the benefits of ML in MO prediction, we explored an automated predictor to estimate MO risk in migraine. To achieve this objective, a study was designed to analyze the performance of a customized ML-based decision support system that combines support vector machines and Random Optimization (RO-MO). Read More

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http://dx.doi.org/10.1016/j.csbj.2020.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327028PMC

Immortalized Dorsal Root Ganglion Neuron Cell Lines.

Front Cell Neurosci 2020 19;14:184. Epub 2020 Jun 19.

Anatomy & Histology, College of Medicine and Public Health, Flinders Health & Medical Research Institute, Flinders University, Adelaide, SA, Australia.

Pain is one of the most significant causes of suffering and disability world-wide, and arguably the most burdensome global health challenge. The growing number of patients suffering from chronic pain conditions such as fibromyalgia, complex regional pain syndrome, migraine and irritable bowel syndrome, not only reflect the complexity and heterogeneity of pain types, but also our lack of understanding of the underlying mechanisms. Sensory neurons within the dorsal root ganglia (DRG) have emerged as viable targets for effective chronic pain therapy. Read More

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http://dx.doi.org/10.3389/fncel.2020.00184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319018PMC

One-year sustained efficacy of erenumab in episodic migraine: Results of the STRIVE study.

Neurology 2020 Jul 7. Epub 2020 Jul 7.

Amgen Inc., Thousand Oaks, CA, USA.

Objective: To assess efficacy and tolerability of 1-year erenumab treatment in patients with episodic migraine.

Methods: Patients were randomized (=955; 1:1:1) during the 24-week double-blind treatment phase (DBTP) to monthly subcutaneous placebo, erenumab 70 or 140mg. At Week 24, 845 patients were re-randomized (1:1) to erenumab 70 or 140mg during the 28-week dose-blinded active-treatment phase (ATP). Read More

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http://dx.doi.org/10.1212/WNL.0000000000010019DOI Listing

External validation of stroke mimic prediction scales in the emergency department.

BMC Neurol 2020 Jul 7;20(1):269. Epub 2020 Jul 7.

Accident and Emergency Department, Changi General Hospital, Singapore, Singapore.

Background: Acute ischemic stroke is a time-sensitive emergency where accurate diagnosis is required promptly. Due to time pressures, stroke mimics who present with similar signs and symptoms as acute ischemic stroke, pose a diagnostic challenge to the emergency physician. With limited access to investigative tools, clinical prediction, tools based only on clinical features, may be useful to identify stroke mimics. Read More

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http://dx.doi.org/10.1186/s12883-020-01846-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339435PMC

Liver Transplant Due to Flupirtine-Induced Acute Liver Failure.

Exp Clin Transplant 2020 Jul 6. Epub 2020 Jul 6.

From the Department of General, Visceral and Vascular Surgery, Jena University Hospital, Jena, Germany.

Objectives: Acute drug-induced liver failure is a rare indication for liver transplant. There is only one case of flupirtine-induced liver failure requiring transplant in the literature. In February 2018, the European Medicines Agency issued a withdrawal of approval for flupirtine medication in European countries as a result of the risk of acute liver failure. Read More

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http://dx.doi.org/10.6002/ect.2019.0297DOI Listing

The influence of friendship on migraine in young adolescents: A social network analysis.

Cephalalgia 2020 Jul 7:333102420940700. Epub 2020 Jul 7.

Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.

Objective: The current study explored whether the chances of having migraine are influenced by a youth's friendship with a migraineur.

Methods: The study was centered on a community-based non-referral cohort of eighth graders from two middle schools in Taiwan. Among the 642 recruited adolescent students, 610 (95%) (mean age 14. Read More

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http://dx.doi.org/10.1177/0333102420940700DOI Listing

Evaluation of 2-Hour Post-Dose Efficacy of Lasmiditan for the Acute Treatment of Difficult-to-Treat Migraine Attacks.

Headache 2020 Jul 7. Epub 2020 Jul 7.

Eli Lilly and Company, Kobe, Japan.

Objective: To identify factors predicting response (2-hour headache pain freedom or most bothersome symptom freedom) to lasmiditan based on individual patient characteristics, migraine disease characteristics, and migraine attack characteristics. Further, efficacy specifically in difficult-to-treat patient/migraine disease characteristics or attack characteristics (ie, historically considered less responsive to certain acute therapies) subgroups was analyzed.

Background: Knowledge of factors associated with a positive or negative response to acute treatment would be useful to practitioners prescribing acute treatments for migraine. Read More

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http://dx.doi.org/10.1111/head.13897DOI Listing

Primary headache in childhood associated with psychiatric disturbances: an update.

Eur Rev Med Pharmacol Sci 2020 Jun;24(12):6893-6898

Department Clinical and Experimental Medicine, Child and Adolescent Neuropsychiatry, University of Catania, Catania, Italy.

Objective: Primary headache disorders in children are one of the most prominent topics in the pediatric neurology literature. However, there are many unsolved aspects, including the conditions associated with migraine. The present study aims to report on the frequency of behavioral comorbidities in the setting of primary headache in childhood. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21680DOI Listing

A real-world analysis of patient-reported outcomes in patients with migraine by preventive treatment eligibility status in the US and Europe.

J Patient Rep Outcomes 2020 Jul 6;4(1):53. Epub 2020 Jul 6.

Adelphi Real World, Bollington, UK.

Background: Migraine has a severe impact on health-related quality of life (HRQoL) affecting physical, emotional, and social aspects of daily living of an individual. Preventive treatment has been demonstrated to improve HRQoL by reducing the frequency of migraine headache days.

Methods: The study used data from 2017 Adelphi Migraine Disease Specific Program, which is a cross-sectional survey of physicians and their consulting patients with migraine in the United States (US) and five European countries (EU [Germany, France, UK, Italy and Spain]). Read More

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http://dx.doi.org/10.1186/s41687-020-00221-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338330PMC

Cortical Mechanisms of Single-Pulse Transcranial Magnetic Stimulation in Migraine.

Neurotherapeutics 2020 Jul 6. Epub 2020 Jul 6.

Headache Research-Wolfson CARD, Guy's Campus, King's College London, London, UK.

Single-pulse transcranial magnetic stimulation (sTMS) of the occipital cortex is an effective migraine treatment. However, its mechanism of action and cortical effects of sTMS in migraine are yet to be elucidated. Using calcium imaging and GCaMP-expressing mice, sTMS did not depolarise neurons and had no effect on vascular tone. Read More

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http://dx.doi.org/10.1007/s13311-020-00879-6DOI Listing

A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine.

Nat Commun 2020 Jul 6;11(1):3368. Epub 2020 Jul 6.

Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.

Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (N/N = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, r = 0.11, P = 3. Read More

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http://dx.doi.org/10.1038/s41467-020-17002-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338361PMC

Selective amplification of ipRGC signals accounts for interictal photophobia in migraine.

Proc Natl Acad Sci U S A 2020 Jul 6. Epub 2020 Jul 6.

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

Second only to headache, photophobia is the most debilitating symptom reported by people with migraine. While the melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs) are thought to play a role, how cone and melanopsin signals are integrated in this pathway to produce visual discomfort is poorly understood. We studied 60 people: 20 without headache and 20 each with interictal photophobia from migraine with or without visual aura. Read More

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http://dx.doi.org/10.1073/pnas.2007402117DOI Listing

Administrative prevalence and incidence, characteristics and prescription patterns of patients with migraine in Germany: a retrospective claims data analysis.

J Headache Pain 2020 Jul 6;21(1):85. Epub 2020 Jul 6.

Evangelical Hospital Unna, Unna, Germany.

Background: Migraine is a frequent headache disorder with high disease burden. The aims of this study were to determine the administrative prevalence and incidence of migraine in Germany; and to elucidate disease characteristics, prescription patterns and the patient journey through the German healthcare system.

Methods: In this retrospective, observational study, adult patients with migraine (International Classification of Diseases, 10th revision, German modification G43) were identified in the anonymised German Company Sickness Fund database (CSFD) from 2008 through 2016. Read More

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http://dx.doi.org/10.1186/s10194-020-01154-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339552PMC

Acute sleep deprivation enhances susceptibility to the migraine substrate cortical spreading depolarization.

J Headache Pain 2020 Jul 6;21(1):86. Epub 2020 Jul 6.

Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

Background: Migraine is a common headache disorder, with cortical spreading depolarization (CSD) considered as the underlying electrophysiological event. CSD is a slowly propagating wave of neuronal and glial depolarization. Sleep disorders are well known risk factors for migraine chronification, and changes in wake-sleep pattern such as sleep deprivation are common migraine triggers. Read More

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http://dx.doi.org/10.1186/s10194-020-01155-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339460PMC

When a Head Is about to Burst: Attachment Mediates the Relationship Between Childhood Trauma and Migraine.

Int J Environ Res Public Health 2020 Jun 25;17(12). Epub 2020 Jun 25.

Olomouc University Social Health Institute, Palacky University Olomouc, 771 11 Olomouc, Czech Republic.

Background: People exposed to childhood trauma show insecure attachment patterns and are more prone to chronic and pain-related conditions, including migraine. The aim of this study was to explore the mediating role of attachment in the association between childhood trauma and adulthood chronic health conditions, with a focus on migraine.

Methods: Respondents from a representative sample of citizens of the Czech Republic ( = 1800, mean age: 46. Read More

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http://dx.doi.org/10.3390/ijerph17124579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344657PMC

Patent Foramen Ovale in Fetal Life, Infancy and Childhood.

Authors:
Bibhuti B Das

Med Sci (Basel) 2020 Jul 1;8(3). Epub 2020 Jul 1.

Department of Pediatric Cardiology, Baylor College of Medicine, Texas Children's Hospital Specialty Care Austin, Austin, TX 78759, USA.

A patent foramen ovale (PFO) is a common, incidental echocardiographic finding in otherwise healthy and asymptomatic infants and children. However, a variety of clinical conditions have been ascribed to the presence of a PFO in childhood, such as cryptogenic stroke, platypnea-orthodeoxia syndrome, decompression sickness and migraine, although the data on these are controversial and sometimes contradictory. This review discusses embryology and correlation with post-natal anatomy, anatomical variations of the atrial septum, diagnostic modalities in special circumstances of PFO associated clinical syndromes, and the role of PFO in congenital heart disease, pulmonary hypertension, dilated cardiomyopathy and heart failure in children who require an extracorporeal membrane oxygenator or ventricular assist device as life support. Read More

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http://dx.doi.org/10.3390/medsci8030025DOI Listing

A Case of Reversible Cerebral Vasoconstriction Syndrome in a Healthy Adult Male.

Cureus 2020 May 31;12(5):e8374. Epub 2020 May 31.

Emergency Medicine, Queen Elizabeth II Health Science Center, Halifax, CAN.

Reversible cerebral vasoconstriction syndrome (RCVS) represents a potentially under-recognized cause of thunderclap headache in patients presenting to the ED. While a rarely made diagnosis in emergency medicine practice, RCVS may be as common as subarachnoid hemorrhage (SAH). RCVS typically presents as a sudden onset, excruciating headache that may be associated with nausea, vomiting, photophobia, or other features with overlap in the clinical presentation of both SAH and migraine headaches. Read More

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http://dx.doi.org/10.7759/cureus.8374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328700PMC

Evaluation of the diagnostic value of clinical characteristics and situations associated with primary headache in children: International classification of headache Disorders-3 edition.

Clin Neurol Neurosurg 2020 Jun 26;196:106039. Epub 2020 Jun 26.

Department of Pediatrics, Çanakkale Onsekiz Mart University, Faculty of Medicine, Çanakkale, Turkey.

Objective: In the childhood period, diagnosis of primary headache is based on anamnesis essentially. This study investigated the effects of characteristics of headache (type of pain, localization and attack time), family migraine history and total duration from onset of headache to clinical diagnosis on primary headache diagnosis.

Patients And Methods: Headache history was taken from children aged 6-18 years with a suitable form of International Classification of Headache Disorders, 3rd edition. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.106039DOI Listing

Neuroimaging findings in headache with normal neurologic examination: Systematic review and meta-analysis.

J Neurol Sci 2020 Jun 26;416:116997. Epub 2020 Jun 26.

Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.

Objective: To determine if pooled estimates of the prevalence of unexpected findings in patients with headache and normal neurologic examination support current expert opinion-based neuroimaging guidelines.

Methods: We searched PubMed and EMBASE for studies reporting neuroimaging findings in patients with headache and normal neurologic examination up to September 30, 2017. The overall and disease-specific prevalence of unexpected findings were pooled through random-effects meta-analysis. Read More

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http://dx.doi.org/10.1016/j.jns.2020.116997DOI Listing

Surgical approach of ectopic maxillary third molar avulsion: systematic review and meta-analysis.

J Stomatol Oral Maxillofac Surg 2020 Jul 1. Epub 2020 Jul 1.

Oral and Maxillofacial Department, Estaing Hospital, CHU Clermont-Ferrand, F-63003 Clermont-Ferrand, France; Université d'Auvergne, Faculty of Medicine, F- 63001, Clermont-Ferrand, France; Université d'Auvergne, Laboratoire CROC EA 3847, Faculty of Dental Surgery, F-63100, Clermont-Ferrand, France; Univ. Lille, INSERM, CHU Lille, U1008 - Controlled Drug Delivery Systems and Biomaterials, F-59000 Lille, France; Cabinet Maxillo-Facial Privé de Saint-Etienne, Hôpital Privé de la Loire, Ramsay GDS, 39 Boulevard de la Palle, 42100 Saint Etienne, France. Electronic address:

Ectopic maxillary third molars (EMTM) are extracted mainly by the Caldwell-Luc technique but also by nasal endoscopy. There is currently no consensus on the treatment of this eruption and its management is heterogeneous and multidisciplinary. Two literature searches were performed with no time restrictions via Pubmed. Read More

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http://dx.doi.org/10.1016/j.jormas.2020.06.015DOI Listing

[Anxiety in neurological practice].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(5):165-170

Scientific Research Institute of General Pathology and Pathophysiology, Moscow, Russia.

Anxiety and related disorders are the most common type of mental disorders in both the general population and the neurological clinic. A current typology of anxiety disorders includes panic disorder, agoraphobia, simple (specific) phobias, social anxiety disorder, and generalized anxiety disorder. Anxiety disorders often accompany diseases of the nervous system, worsen their course and impede treatment, and the degree of anxiety usually corresponds to the severity of neurological symptoms. Read More

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http://dx.doi.org/10.17116/jnevro2020120051165DOI Listing

An Emerging Role for Prolactin in Female-Selective Pain.

Trends Neurosci 2020 Jun 30. Epub 2020 Jun 30.

Department of Pharmacology, University of Arizona, Tucson, AZ, USA; Mayo Clinic, Scottsdale, AZ, USA. Electronic address:

Women experience many pain conditions more frequently when compared with men, but the biological mechanisms underlying sex differences in pain remain poorly understood. In particular, little is known about possible sex differences in peripheral nociceptors, the fundamental building blocks of pain transmission. Emerging evidence reveals that prolactin (PRL) signaling at its cognate prolactin receptor (PRLR) in primary afferents promotes nociceptor sensitization and pain in a female-selective fashion. Read More

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http://dx.doi.org/10.1016/j.tins.2020.06.003DOI Listing

Cardiovascular and somatic comorbidities and sleep measures using three hypopnea criteria in mild obstructive sleep-disordered breathing: sex, age and body mass index differences in a retrospective sleep clinic cohort.

J Clin Sleep Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Medicine, Baystate Medical Center, University of Massachusetts Medical School -Baystate, Springfield, Massachusetts.

Study Objectives: To describe sex, age and body mass index (BMI) differences in comorbidities and polysomnography (PSG) measures, categorized using three different apnea-hypopnea index (AHI) criterion, in sleep clinic patients with mild obstructive sleep-disordered breathing (SDB).

Methods: A retrospective cohort of 305 (64% female) adult sleep clinic patients who underwent full night in-laboratory polysomnography diagnosed with mild SDB and prescribed positive airway pressure (PAP). Effects of sex, age and BMI on comorbidities and PSG measures including rates of AHI defined by ≥3% desaturations (AHI), with arousals (AHI), by ≥4% desaturations (AHI) and by respiratory disturbance index (RDI) were evaluated. Read More

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http://dx.doi.org/10.5664/jcsm.8644DOI Listing

Erenumab in highly therapy-refractory migraine patients: First German real-world evidence.

J Headache Pain 2020 Jul 3;21(1):84. Epub 2020 Jul 3.

Department of Neurology, West German Headache Center, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.

Background: Calcitonin gene related peptide (CGRP) monoclonal antibodies (mAB) are the first specific migraine prophylactic medication. Erenumab is the only CGRP mAB targeting the CGRP receptor. Clinical data regarding efficacy and tolerability of erenumab in highly therapy-refractory patients are not available, yet, although many patients treated with CGRP mAB under real world conditions can be considered as highly therapy-refractory. Read More

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http://dx.doi.org/10.1186/s10194-020-01151-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333436PMC

Auditory attention alterations in migraine: A behavioral and MEG/EEG study.

Clin Neurophysiol 2020 Jun 18;131(8):1933-1946. Epub 2020 Jun 18.

Lyon Neuroscience Research Center (CRNL), INSERM UMRS 1028, CNRS UMR 5292, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.

Objectives: To evaluate alterations of top-down and/or bottom-up attention in migraine and their cortical underpinnings.

Methods: 19 migraineurs between attacks and 19 matched control participants performed a task evaluating jointly top-down and bottom-up attention, using visually-cued target sounds and unexpected task-irrelevant distracting sounds. Behavioral responses and magneto- and electro-encephalography signals were recorded. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.05.024DOI Listing

Is Noninvasive Vagus Nerve Stimulation a Safe and Effective Alternative to Medication for Acute Migraine Control?

Neurologist 2020 Jul;25(4):97-100

Departments of Neurology.

Background: Noninvasive neuromodulation devices have been used for a variety of headache disorders, including cluster and migraine, since recently being cleared by the Federal Drug Administration. Although these devices have been touted as low-risk options for improved headache control, the data behind actual efficacy endpoints remain unclear.

Objective: To critically assess current evidence regarding the efficacy of the noninvasive vagus nerve stimulator (nVNS) device for acute migraine management. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000274DOI Listing

Cardiovascular and somatic comorbidities and sleep measures using three hypopnea criteria in mild obstructive sleep-disordered breathing: sex, age and body mass index differences in a retrospective sleep clinic cohort.

J Clin Sleep Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Medicine, Baystate Medical Center, University of Massachusetts Medical School -Baystate, Springfield, Massachusetts.

Study Objectives: To describe sex, age and body mass index (BMI) differences in comorbidities and polysomnography (PSG) measures, categorized using three different apnea-hypopnea index (AHI) criterion, in sleep clinic patients with mild obstructive sleep-disordered breathing (SDB).

Methods: A retrospective cohort of 305 (64% female) adult sleep clinic patients who underwent full night in-laboratory polysomnography diagnosed with mild SDB and prescribed positive airway pressure (PAP). Effects of sex, age and BMI on comorbidities and PSG measures including rates of AHI defined by ≥3% desaturations (AHI), with arousals (AHI), by ≥4% desaturations (AHI) and by respiratory disturbance index (RDI) were evaluated. Read More

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Potentially Reversible and Recognizable Acute Encephalopathic Syndromes: Disease Categorization and MRI Appearances.

AJNR Am J Neuroradiol 2020 Jul 2. Epub 2020 Jul 2.

Department of Radiology (A.M.M.), University of Miami School of Medicine, Miami, Florida.

"Encephalopathy" is a vague term that encompasses varying definitions, often with a nonspecific clinical presentation and numerous possible pathophysiologic causes. Hence, MR imaging plays a crucial role in the early diagnosis and treatment by identifying imaging patterns when there is limited clinical history in such patients with acute encephalopathy. The aim of this review was to aid in remembrance of etiologies of potentially reversible acute encephalopathic syndromes on MR imaging. Read More

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http://dx.doi.org/10.3174/ajnr.A6634DOI Listing

P2X7 receptors exert a permissive effect on the activation of presynaptic AMPA receptors in rat trigeminal caudal nucleus glutamatergic nerve terminals.

J Headache Pain 2020 Jul 2;21(1):83. Epub 2020 Jul 2.

Institute of Pharmacology, School of Medicine, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168, Rome, Italy.

Background: Purine receptors play roles in peripheral and central sensitization and are associated with migraine headache. We investigated the possibility that ATP plays a permissive role in the activation of AMPA receptors thus inducing Glu release from nerve terminals isolated from the rat trigeminal caudal nucleus (TCN).

Methods: Nerve endings isolated from the rat TCN were loaded with [H]D-aspartic acid ([H]D-ASP), layered into thermostated superfusion chambers, and perfused continuously with physiological medium, alone or with various test drugs. Read More

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http://dx.doi.org/10.1186/s10194-020-01153-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330953PMC

Ubrogepant does not induce latent sensitization in a preclinical model of medication overuse headache.

Cephalalgia 2020 Jul 2:333102420938652. Epub 2020 Jul 2.

Department of Pharmacology, Arizona Health Sciences Center, University of Arizona, Tucson, AZ, USA.

Background: Ubrogepant, a small-molecule calcitonin gene-related peptide receptor antagonist, was recently approved as an oral medication for the acute treatment of migraine. This study aimed to determine whether ubrogepant shows efficacy in a preclinical model of migraine-like pain and whether repeated oral administration of ubrogepant induces latent sensitization relevant to medication overuse headache in rats.

Methods: A "two-hit" priming model of medication overuse headache was used. Read More

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http://dx.doi.org/10.1177/0333102420938652DOI Listing

Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta-Analysis.

Headache 2020 Jul 2. Epub 2020 Jul 2.

Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, Larissa, Greece.

Background: Migraine, especially migraine with aura (MA), has been linked to increased risk for ischemic cerebrovascular disease. The possible role of elevated serum homocysteine (Hcy, a cause of thrombophilia) in migraine has been demonstrated by several studies.

Objective: The present study aims to review and meta-analyze data from studies investigating the difference of serum Hcy and Hcy lowering vitamins between migraine patients and healthy controls (HC), as well as between patients with MA and migraine without aura (MO). Read More

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http://dx.doi.org/10.1111/head.13892DOI Listing

Impact of quarantine due to COVID infection on migraine: a survey in Genova, Italy.

Neurol Sci 2020 Jul 1. Epub 2020 Jul 1.

Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy.

Quarantine is a well-known risk factor for psychological and psychiatric disturbances. We evaluated burden of migraine during lockdown due to COVID 19 pandemia. Forty-nine subjects followed in our headache clinic for migraine were evaluated for migraine burden by means of global assessment of migraine severity (GAMS) and visual analogue scale (VAS) by phone interview. Read More

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http://dx.doi.org/10.1007/s10072-020-04543-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329264PMC

Localization of TRPA1 channels and characterization of TRPA1 mediated responses in dural and pial arteries in vivo after intracarotid infusion of NaS.

Cephalalgia 2020 Jul 1:333102420937724. Epub 2020 Jul 1.

Department of Neurology, Danish Headache Center, Rigshospitalet, Glostrup, Denmark.

Background: The Transient Receptor Potential Ankyrin 1 (TRPA1) channel might play a role in migraine. However, different mechanisms for this have been suggested. The purpose of our study was to investigate the localization and significance of TRPA1 channels in rat pial and dural arteries. Read More

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http://dx.doi.org/10.1177/0333102420937724DOI Listing

TRPM8 channels: A review of distribution and clinical role.

Eur J Pharmacol 2020 Jun 28:173312. Epub 2020 Jun 28.

Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Jiangsu Province, Nanjing, 211198, PR China; Department of Surgery, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu Province, 210017, PR China; Department of Surgery, Nanjing Shuiximen Hospital, Jiangsu Province, 210017, PR China. Electronic address:

Ion channels are important therapeutic targets due to their plethoric involvement in physiological and pathological consequences. The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a nonselective cation channel that controls Ca homeostasis. It has been proposed to be the predominant thermoreceptor for cellular and behavioral responses to cold stimuli in the TRP channel subfamilies and exploited so far to reach the clinical-stage of drug development. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173312DOI Listing