Search Our Scientific Publications & Authors

J Headache Pain 2022 Jun 25;23(1):71. Epub 2022 Jun 25.

Department of Neurology, the First Medical Center, Chinese PLA General Hospital, Fuxing Road 28, Haidian District, 100853, Beijing, People's Republic of China.

Background: Gut microbial dysbiosis and gut-brain axis dysfunction have been implicated in the pathophysiology of migraine. However, it is unclear whether migraine-related cephalic allodynia could induce the alteration of gut microbial composition.

Methods: A classic migraine rat model was established by repeated dural infusions of inflammatory soup (IS). Read More

Curr Pain Headache Rep 2022 Jun 25. Epub 2022 Jun 25.

Lewis Headache Center, Department of Neurology, Barrow Neurological Institute | St Joseph Health Center, 350 W. Thomas Rd, AZ, 85013, Phoenix, USA.

Purpose Of Review: The authors present data on cardiovascular safety for the new acute and preventive migraine treatments including ditans, gepants, and calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) alongside older medications like triptans and ergotamines.

Recent Findings: The authors conclude that there are no cardiovascular safety concerns for lasmiditan, and that it could be used in those with cardiovascular disease. In fact, the literature even suggests that triptans are safer in cardiovascular disease than their contraindications may suggest. Read More

Indian Pediatr 2022 Jun 11. Epub 2022 Jun 11.

Department of Pediatric Neurology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu.

Objective: To study the association between serum magnesium level and migraine in children.

Methods: This cross-sectional study enrolled children aged 5-18 years diagnosed with migraine, and age-and sex-matched controls without a headache disorder. International Classification of Headache Disorders 3 (ICHD-3) was used for the diagnosis of migraine. Read More

J Pak Med Assoc 2022 Jun;72(6):1153-1157

Department of Neurosurgery, Combined Military Hospital, Muzaffarabad, Pakistan.

Objective: To determine the effect of aerobic exercises and progressive muscle relaxation in migraine patients.

Methods: The quasi-experimental study was conducted at the Sheikh Khalifa Bin Zayed Al Nayhan Hospital / Combined Military Hospital, Muzaffarabad, Azad Jammu and Kashmir, from February to July 2017, and comprised migraine patients of either gender aged 20-50 years. They were divided into experimental and control group. Read More

Aging Clin Exp Res 2022 Jun 24. Epub 2022 Jun 24.

Dipartimento di Biomedicina Neuroscienze e Diagnostica avanzata, UNIPA BiND: Università degli Studi di Palermo, Palermo, Italy.

BMJ Open 2022 Jun 24;12(6):e061287. Epub 2022 Jun 24.

School of Second Clinical Medicine/The Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, Yunnan, China

Introduction: Migraine is a common neurological disorder with a higher prevalence occurring in women. Migraine without aura (MwoA) is the most common type of migraine. In recent years, the safety and effectiveness of acupuncture for migraines have been internationally recognised. Read More

Am J Ophthalmol 2022 Jun 21. Epub 2022 Jun 21.

Mayo Clinic Department of Ophthalmology, 200 First Street SW, Rochester, MN 55905. Electronic address:

Purpose: To report outcomes of patients presenting to the emergency department (ED) with new-onset visual flashes and/or floaters following implementation of a formalized triage protocol allowing eligible patients to be discharged for prompt outpatient ophthalmic examination.

Design: Retrospective consecutive case series.

Methods: Patient characteristics, protocol eligibility, and clinical outcomes were recorded for adult patients triaged within a formal "flashes and floaters" protocol at a single academic emergency department. Read More

Headache 2022 Jun 24. Epub 2022 Jun 24.

Tel-Aviv University Sackler School of Medicine, Tel-Aviv, Israel.

Objective: To evaluate the efficacy and safety of concurrent non-invasive stimulation of occipital and trigeminal nerves in acute treatment of migraine with or without aura.

Background: Non-invasive neuromodulation devices stimulating a single peripheral nerve or anatomic distribution are routinely used by patients with migraine refractory to the first-line drugs or those who opt out of pharmaceutical treatment. Concurrent occipital and trigeminal stimulation was described in an invasive setting, and its safety cost outweighed its efficacy gain. Read More

Expert Opin Drug Saf 2022 Jun 24:1-9. Epub 2022 Jun 24.

Headache Center, Dokkyo Medical University, Mibu, Japan.

Background: Some migraine treatments are contraindicated for patients with cardiovascular disease (CVD) or risk factors (CVRFs). We report safety and efficacy of lasmiditan, a new oral acute migraine treatment with no cardiovascular contraindication, in Japanese patients with CVRFs.

Research Design And Methods: MONONOFU was a multicenter, randomized, double-blind, placebo-controlled, phase 2 study of Japanese patients with migraine (met International Headache Society criteria, Migraine Disability Assessment score ≥11, disabling migraine for ≥1 year). Read More

Neurol Genet 2022 Aug 20;8(4):e200001. Epub 2022 May 20.

Department of Neurology and Rehabilitation Medicine (J.S., A.J.E., E.J.H.), University of Cincinnati; and Department of Human Genetics (A.S.), Cincinnati Children's Hospital Medical Center, OH.

Objective: To describe a family with primary familial brain calcifications (PFBCs) and leukoencephalopathy associated with a novel variant in .

Methods: We present 3 generations of a family with PFBC associated with a previously unreported variant in .

Results: A 24-year-old woman with migraine, bipolar disorder, and functional neurologic disorder was found to have bilateral calcifications of the basal ganglia and frontally predominant periventricular white matter disease. Read More

Br J Cardiol 2022 8;29(1). Epub 2022 Mar 8.

Independent Nurse, Founder of Learn With Nurses, and Trustee, PoTS UK Smart Health Solutions, 2-6 Boundary Road, London, SE1 8HP.

J Pers Med 2022 May 24;12(6). Epub 2022 May 24.

Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan.

Pain assessment is essential for preclinical and clinical studies on pain. The mouse grimace scale (MGS), consisting of five grimace action units, is a reliable measurement of spontaneous pain in mice. However, MGS scoring is labor-intensive and time-consuming. Read More

J Clin Med 2022 Jun 12;11(12). Epub 2022 Jun 12.

Neurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Via Amendola 2, 42122 Reggio Emilia, RE, Italy.

Transient global amnesia (TGA) is a clinical syndrome characterized by the sudden onset of a temporary memory disorder with a profound anterograde amnesia and a variable impairment of the past memory. Since the first description, dating back over 60 years, several cases have beenreported in the literature. Nevertheless, TGA remains one of the most mysterious diseases in clinical neurology. Read More

J Ethnopharmacol 2022 Jun 20:115470. Epub 2022 Jun 20.

Jiangxi University of Chinese Medicine, No. 818 Yunwan Road, Nanchang, 330002, PR China.

Ethnopharmacological Relevance: San Pian decoction (SPD), a traditional Chinese medicine preparation composed of eight herbs, has been reported to alleviate migraine. However, its active ingredients and the potential mechanism of action remains unclear. The purpose of this study was to comprehensively analyze SPD for the treatment of chronic migraine based on pharmacological direction and to identify the active ingredients and pharmacological mechanism of SPD in the treatment of migraine. Read More

Neurol Int 2022 May 31;14(2):488-496. Epub 2022 May 31.

Neurology Department, NYU Langone Health, New York, NY 10017, USA.

(1) Background: Reversible cerebral vasoconstriction syndrome (RCVS) encompasses a clinical and radiological diagnosis characterized by recurrent thunderclap headache, with or without focal deficits due to multifocal arterial vasoconstriction and dilation. RCVS can be correlated to pregnancy and exposure to certain drugs. Currently, the data on prevalence of RCVS in the postpartum period is lacking. Read More

Expert Opin Drug Saf 2022 Jun 23. Epub 2022 Jun 23.

Eli Lilly Japan K.K., 5-1-28 Isogamidori, Chuo-Ku, Kobe, Hyogo, Japan.

Background: MONONOFU, a multicenter, randomized, double-blind, placebo-controlled phase 2 study of Japanese patients with migraine, was pivotal for lasmiditan approval in Japan. However, treatment-emergent adverse events (TEAEs) were more common than in global studies. A detailed safety profile would assist patient management. Read More

Brain 2022 Jun 23. Epub 2022 Jun 23.

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Migraine is a highly common and debilitating disorder that often affects individuals in their most productive years of life. Previous studies have identified both genetic variants and brain morphometry differences associated with migraine risk. However, the relationship between migraine and brain morphometry has not been examined on a genetic level, and the causal nature of the association between brain structure and migraine risk has not been determined. Read More

Ann Med Surg (Lond) 2022 Jun 27;78:103862. Epub 2022 May 27.

Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.

Background: Mindfulness-based stress reduction/cognitive therapy has attained popularity as an adjunctive treatment for a plethora of medical and psychiatric conditions, however, its impact on chronic headaches is inconclusive. This review aims to assess the impact of MBSR/MBCT in alleviating the symptoms of chronic headaches.

Data Sources And Data Selection: PubMed and Cochrane CENTRAL were searched from inception till 1st May 2021. Read More

Heliyon 2022 Jun 7;8(6):e09688. Epub 2022 Jun 7.

Institute of Psychology, Faculty of Education and Psychology, ELTE Eötvös Loránd University, Budapest, Hungary.

Background: Previous findings suggest a female preponderance in nonproductive thoughts -rumination and worry-, but studies on gender differences in the strength of the relationship between nonproductive thoughts, somatic symptoms and subjective well-being are scarce. Our aim was to test whether gender and age would moderate these associations.

Methods: 1572 adolescents were involved in this representative cross-sectional study (770 boys; mean age = 15. Read More

Neurobiol Pain 2022 Aug-Dec;12:100096. Epub 2022 Jun 13.

Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, United States.

Low-dose interleukin-2 (LD-IL-2) treatment has been shown to effectively reverse chronic migraine-related behaviors and the sensitization of trigeminal ganglion (TG) neurons through expansion and activation of peripheral regulatory T cells (Tregs) in mice. In this study, we investigated the molecular mechanisms underlying the effects of LD-IL-2 and Treg cells. LD-IL-2 treatment increases the production of cytokines interleukin-10 (IL-10) and transforming growth factor beta-1 (TGFβ1) in T cells, especially Treg cells, suggesting that they may mediate the therapeutic effect of LD-IL-2. Read More

J Child Neurol 2022 Jun 22:8830738221092882. Epub 2022 Jun 22.

Pediatric Department, Cairo University, Cairo, Egypt.

There is still a need for more studies to evaluate the role of vitamin D in pediatric migraine prophylaxis. We aimed to evaluate the effects and safety of vitamin D supplementation to topiramate on pediatric migraine. A double-blinded prospective clinical trial was conducted on 5- to 14-year-old children with migraine. Read More

BMC Neurol 2022 Jun 22;22(1):230. Epub 2022 Jun 22.

Department of Psychology, Khomainishahr Branch, Islamic Azad University, Khomainishahr, Isfahan, Iran.

Introduction: Psychological interventions are shown to be effective in migraine, but not utilized routinely yet. We aimed to evaluate the efficacy of transdiagnostic cognitive behavioral therapy (TCBT) on people with migraine (PwM).

Method: This study was conducted on 40 PwM aged 20-50 years. Read More

J Headache Pain 2022 Jun 23;23(1):70. Epub 2022 Jun 23.

Medical Affairs, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima, 771-0192, Japan.

Background: Migraine is a chronic disease characterized by episodic headache attacks. No recent studies have, however been conducted on the epidemiology of migraine or the treatment landscape in Japan. This study was conducted as a fact-finding survey using medical claims data and an online survey on migraine and headaches, conducted among members of health insurance associations with the objective of gaining an understanding of migraine prevalence and the treatment status in Japan. Read More

Sci Rep 2022 Jun 22;12(1):10512. Epub 2022 Jun 22.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

To assess association between migraines and development of ocular motor cranial nerve palsy (CNP) and finding risk factors using the National Sample Cohort database from the Korea National Health Insurance Service. Data was analyzed from 4,234,341 medical screening examinees aged 20-90 years in 2009. Cox proportional hazard regression analysis was used to the adjusted hazard ratios (HR) for ocular motor CNP according to presence of migraine. Read More

Ear Hear 2022 Jun 22. Epub 2022 Jun 22.

Amsterdam UMC location Vrije Universiteit Amsterdam, Otolaryngology-Head and Neck Surgery, Section Ear and Hearing, Amsterdam, The Netherlands.

Objectives: Tinnitus is highly prevalent, but only a few risk factors for developing tinnitus are known and little is known about factors associated with the degree of annoyance of new-onset tinnitus. Longitudinal analysis can reveal risk factors associated with the development of tinnitus and might lead to targeted prevention. The aim of this study is twofold. Read More

BMC Neurol 2022 Jun 21;22(1):227. Epub 2022 Jun 21.

Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Hezar Jarib Street, Isfahan, 73461-81746, Iran.

Objectives: Ischemic stroke is the most common presentation of cervical artery dissection (CAD). Information regarding CAD-induced stroke is scarce, especially in the Middle East. Here we investigated the incidence of CAD-induced stroke, its characteristics, and the clinical course in central Iran. Read More

Eur J Clin Pharmacol 2022 Jun 22. Epub 2022 Jun 22.

College of Pharmacy, Kyungsung University, 309, Suyeong-ro, Nam-gu, Busan, 48434, Republic of Korea.

Objective: Calcitonin gene-related peptide (CGRP) receptor antagonists have been suggested as novel treatments for acute migraine. This study aimed to use meta-analysis to compare the safety and tolerability of five existing oral CGRP receptor antagonists (BI44370TA, MK-3207, rimegepant, telcagepant, and ubrogepant) with that of a placebo or triptans against acute migraine.

Methods: Five prominent databases were searched to identify randomized controlled trials on this topic. Read More

Clin Drug Investig 2022 Jun 21. Epub 2022 Jun 21.

Clinical Trial Center/NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug, West China Hospital of Sichuan University, No.5 Telecom Road, Wuhou District, Chengdu, 610041, China.

Background And Objective: Erenumab is the first-in-class, selective, and competitive human monoclonal antibody antagonist of the calcitonin gene-related peptide (CGRP) receptor that has been shown to be effective and well-tolerated in the preventive therapy of episodic and chronic migraine. The pharmacokinetics of erenumab may be affected by differences in race and ethnicity, which can lead to suboptimal outcomes. The present study was conducted to assess the single-dose pharmacokinetics and safety of erenumab in healthy Chinese subjects. Read More

Acad Emerg Med 2022 Jun 21. Epub 2022 Jun 21.

University of Washington, Anesthesiology & Pain Medicine, & Seattle Children's Research Institute, Center for Child Health, Behavior & Development, Seattle, WA, USA.

There are disparities in pain management for children presenting to the emergency department (ED) according to their racial and ethnic backgrounds. It is not known if there are differences in the treatment of pain associated with pediatric migraines by race, ethnicity, and language for care (REaL). We analyzed treatment patterns and outcomes in our ED for acute migraine in pediatric patients by REaL. Read More

Acta Neurol Scand 2022 Jun 21. Epub 2022 Jun 21.

Grupo de Investigación en Neurociencia, Efectividad Clínica y Salud Pública, Universidad Científica del Sur, Lima, Peru.

Introduction: Greater occipital nerve block (GONB) is a minimally invasive procedure frequently used in patients with chronic migraine (CM); however, the quality of the evidence supporting its use is still unknown. Therefore, we aimed to conduct a systematic review, meta-analysis and quality assessment of GONB local anaesthetics combined or not with corticosteroids to prevent CM.

Methods: We searched Medline, Scopus and Web of Science up to October 2020. Read More