Pain 2021 May 31. Epub 2021 May 31.
Department of Pharmaceutical Sciences and Center for Biomolecular Science, University of Illinois, Chicago, IL 60612 Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Austin, Texas, USA Department of Neurology & Rehabilitation, University of Illinois, Chicago, IL 60612 Department of Bioengineering, University of Illinois, Chicago, IL 60607.
Abstract: Migraine is one of the most common neurological disorders characterized by recurrent attacks of typically throbbing and unilateral headaches, affecting up to 20 % of the population worldwide. Despite the high prevalence and severity of this primary headache disorder, it remains to be a challenge to fully understand and treat migraine headaches. By characterizing and validating a mouse migraine model, this study aimed to investigate the functional contribution of PKC isoforms in migraine. Read More