34,658 results match your criteria Migraine Headache


Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta-Analysis.

Headache 2020 Jul 2. Epub 2020 Jul 2.

Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, Larissa, Greece.

Background: Migraine, especially migraine with aura (MA), has been linked to increased risk for ischemic cerebrovascular disease. The possible role of elevated serum homocysteine (Hcy, a cause of thrombophilia) in migraine has been demonstrated by several studies.

Objective: The present study aims to review and meta-analyze data from studies investigating the difference of serum Hcy and Hcy lowering vitamins between migraine patients and healthy controls (HC), as well as between patients with MA and migraine without aura (MO). Read More

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http://dx.doi.org/10.1111/head.13892DOI Listing

Impact of quarantine due to COVID infection on migraine: a survey in Genova, Italy.

Neurol Sci 2020 Jul 1. Epub 2020 Jul 1.

Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy.

Quarantine is a well-known risk factor for psychological and psychiatric disturbances. We evaluated burden of migraine during lockdown due to COVID 19 pandemia. Forty-nine subjects followed in our headache clinic for migraine were evaluated for migraine burden by means of global assessment of migraine severity (GAMS) and visual analogue scale (VAS) by phone interview. Read More

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http://dx.doi.org/10.1007/s10072-020-04543-xDOI Listing

Localization of TRPA1 channels and characterization of TRPA1 mediated responses in dural and pial arteries in vivo after intracarotid infusion of NaS.

Cephalalgia 2020 Jul 1:333102420937724. Epub 2020 Jul 1.

Department of Neurology, Danish Headache Center, Rigshospitalet, Glostrup, Denmark.

Background: The Transient Receptor Potential Ankyrin 1 (TRPA1) channel might play a role in migraine. However, different mechanisms for this have been suggested. The purpose of our study was to investigate the localization and significance of TRPA1 channels in rat pial and dural arteries. Read More

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http://dx.doi.org/10.1177/0333102420937724DOI Listing

TRPM8 channels: A review of distribution and clinical role.

Eur J Pharmacol 2020 Jun 28:173312. Epub 2020 Jun 28.

Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Jiangsu Province, Nanjing, 211198, PR China; Department of Surgery, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu Province, 210017, PR China; Department of Surgery, Nanjing Shuiximen Hospital, Jiangsu Province, 210017, PR China. Electronic address:

Ion channels are important therapeutic targets due to their plethoric involvement in physiological and pathological consequences. The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a nonselective cation channel that controls Ca homeostasis. It has been proposed to be the predominant thermoreceptor for cellular and behavioral responses to cold stimuli in the TRP channel subfamilies and exploited so far to reach the clinical-stage of drug development. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173312DOI Listing

Markedly Increased Prevalence of Migraine Headaches in Adolescents with Bipolar Disorder.

Bipolar Disord 2020 Jul 1. Epub 2020 Jul 1.

Centre for Youth Bipolar Disorder, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Objective: There is substantial evidence of increased prevalence of migraines, and negative psychiatric correlates of migraines, in adults withbipolar disorder (BD). Given the paucity of data on this topic in youth, we investigated the prevalence and correlates of migraine in a large sample of adolescents with BD.

Method: The study included 165 adolescents with BD-I, -II or -not otherwise specified (NOS), diagnosed via the KSADS-PL semi-structured interview, and 89 healthy controls (HCs). Read More

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http://dx.doi.org/10.1111/bdi.12972DOI Listing

Co-occurrences of substance use and other potentially addictive behaviors: Epidemiological results from the Psychological and Genetic Factors of the Addictive Behaviors (PGA) Study.

J Behav Addict 2020 Jun 26. Epub 2020 Jun 26.

1Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary.

Background And Aims: Changes in the nomenclature of addictions suggest a significant shift in the conceptualization of addictions, where non-substance related behaviors can also be classified as addictions. A large amount of data provides empirical evidence that there are overlaps of different types of addictive behaviors in etiology, phenomenology, and in the underlying psychological and biological mechanisms. Our aim was to investigate the co-occurrences of a wide range of substance use and behavioral addictions. Read More

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http://dx.doi.org/10.1556/2006.2020.00033DOI Listing

The Epidemiology of Migraine Headache in Arab Countries: A Systematic Review.

ScientificWorldJournal 2020 16;2020:4790254. Epub 2020 Jun 16.

Ministry of Health, Riyadh, Saudi Arabia.

Background: Recurring migraine disorders are a common medical problem, standing among the top causes of disability and sufferings. This study aimed to evaluate epidemiological evidence to report updated estimates on prevalence, risk factors, and associated comorbidities of migraine headache in the Arab countries. . Read More

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http://dx.doi.org/10.1155/2020/4790254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315321PMC

Mechanism of Action of OnabotulinumtoxinA in Chronic Migraine: A Narrative Review.

Headache 2020 Jun 30. Epub 2020 Jun 30.

Allergan, Inc., Irvine, CA, USA.

Objective: To review the literature on the mechanism of action of onabotulinumtoxinA in chronic migraine.

Background: OnabotulinumtoxinA is a chronic migraine preventive treatment that significantly reduces headache frequency. The traditional mechanism described for onabotulinumtoxinA - reducing muscle contractions - is insufficient to explain its efficacy in migraine, which is primarily a sensory neurological disease. Read More

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http://dx.doi.org/10.1111/head.13849DOI Listing

Cinnarizine as alternative recommendation for migraine prophylaxis: a narrative review.

Expert Rev Neurother 2020 Jun 29. Epub 2020 Jun 29.

Headache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences , Tehran, Iran.

Introduction: Despite the available prophylactic and acute drugs for migraine management, this disabling disorder remains undertreated especially among pediatrics. In this review, the authors aim at assessing the preventive role cinnarizine plays in treating migraine based on previously published studies.

Areas Covered: Randomized clinical trials, randomized controlled trials, non-randomized open-label trials and retrospective studies concerning cinnarizine in migraine prevention in children and adults were reviewed. Read More

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http://dx.doi.org/10.1080/14737175.2020.1787834DOI Listing

Two-hour infusion of vasoactive intestinal polypeptide induces delayed headache and extracranial vasodilation in healthy volunteers.

Cephalalgia 2020 Jun 27:333102420937655. Epub 2020 Jun 27.

Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Background: In recent years, vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptides (PACAPs) have gained special interest in headache science. VIP and PACAPs (two isoforms, PACAP27 and PACAP38) are related in structure and function, as are their receptors, but they show differences in vasodilating- and headache-inducing properties. Intravenous infusion of PACAP27 or PACAP38, but not VIP, induces a long-lasting dilation of cranial arteries and delayed headache. Read More

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http://dx.doi.org/10.1177/0333102420937655DOI Listing

Failure of preventive treatments in migraine: an observational retrospective study in a tertiary headache center.

BMC Neurol 2020 Jun 27;20(1):256. Epub 2020 Jun 27.

Applied Neurophysiology and Pain Unit, Basic Medical Sciences, Neuroscience and Sensory System Department-SMBNOS, Bari Aldo Moro University, Policlinico General Hospital, Giovanni XXIII Building, Via Amendola 207, A 70124, Bari, Italy.

Background: Although the criteria for acute migraine treatment and prevention have been well described, there are still unmet needs, general underuse and low benefits of preventive drugs. The aim of the present study was to retrospectively observe the short-term effect of preventive treatment in a cohort of migraine patients attending a tertiary headache center, using data from electronic medical records.

Methods: This was an observational retrospective cohort study based on data collected in a tertiary headache center. Read More

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http://dx.doi.org/10.1186/s12883-020-01839-5DOI Listing

Cranial Autonomic Symptoms of Migraine in Japan: Prospective Study of 373 Migraine Patients at a Tertiary Headache Center.

Headache 2020 Jun 27. Epub 2020 Jun 27.

Headache Center, Department of Neurology, Tominaga Hospital, Osaka, Japan.

Objective: To clarify the detailed clinical characteristics of cranial autonomic symptoms (CAS) of Japanese patients with migraine and to get insight into the pathophysiological implications.

Background: Recent studies reported that CAS in migraine is causing diagnostic confusion with cluster headache or sinus headache; however, most reports have concerned Caucasians, and Asian data are scarce. The regional differences in the clinical characteristics of primary headaches between Caucasians and Asians have also been revealed recently. Read More

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http://dx.doi.org/10.1111/head.13888DOI Listing

Evaluation of retinal vessel density and choriocapillaris flow in migraine patients with and without aura.

Graefes Arch Clin Exp Ophthalmol 2020 Jun 26. Epub 2020 Jun 26.

Department of Ophthalmology, Ankara University School of Medicine, Ankara, Turkey.

Purpose: Migraine is thought to be a neurovascular disorder and increases the likelyhood to develop ischemic complications. Studies have shown that vascular disorders such as ischemic optic neuropathy, retinal artery and vein obstructions are more common in patients with migraine. This study aimed to evaluate the differences between retinal and optic disc microvasculature between migraine patients with and without aura and healthy controls using optical coherence tomography angiography (OCTA) imaging. Read More

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http://dx.doi.org/10.1007/s00417-020-04805-6DOI Listing

Serum levels of allopregnanolone, progesterone and testosterone in menstrually-related and postmenopausal migraine: A cross-sectional study.

Cephalalgia 2020 Jun 26:333102420937742. Epub 2020 Jun 26.

Unit of Medical Toxicology, Headache Centre and Drug Abuse; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Background: Reduced blood or cerebrospinal fluid levels of allopregnanolone are involved in menstrual cycle-linked CNS disorders, such as catamenial epilepsy. This condition, like menstrually-related migraine, is characterized by severe, treatment-resistant attacks. We explored whether there were differences in allopregnanolone, progesterone and testosterone serum levels between women with menstrually-related migraine (MM, n = 30) or postmenopausal migraine without aura who had suffered from menstrually-related migraine during their fertile age (PM, n = 30) and non-headache control women in fertile age (FAC, n = 30) or post-menopause (PC, n = 30). Read More

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http://dx.doi.org/10.1177/0333102420937742DOI Listing

Efficacy of adding midazolam to paracetamol in pain control of patients with a primary headache: A randomized, clinical trial study.

Turk J Emerg Med 2020 Apr-Jun;20(2):63-68. Epub 2020 May 27.

Emergency Medicine Department, Tabriz University of Medical Sciences, Tabriz, Iran.

Objectives: This study aimed to determine the effect of adding intravenous midazolam to paracetamol in the treatment of patients with primary headache referring to the emergency department.

Methods: In a randomized clinical trial, 120 patients (18-65 years old) with primary headache referring to the emergency department were enrolled. Patients were divided into two groups (case: paracetamol + midazolam and control: paracetamol + placebo), and the treatment was administered based on the treatment group. Read More

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http://dx.doi.org/10.4103/2452-2473.285011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305668PMC

Significant incidental brain magnetic resonance imaging findings in migraine headache patients: Retrospective cross-sectional study.

Clin Neurol Neurosurg 2020 Jun 18;196:106019. Epub 2020 Jun 18.

Neuroscience Clinic and First Scan Radiology Department, First Clinic, Jeddah, Saudi Arabia; Division of Neurosurgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address:

Background: Migraine is one of the most common complaints encountered in neurology clinics. Accurate diagnoses of migraine are usually informed by the patient's history, and neuroimaging is only performed in cases of atypical or severe, medically intractable headache to rule out underlying pathologies. Our study aimed to identify the spectrum of brain magnetic resonance imaging (MRI) findings characteristic of chronic headache. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.106019DOI Listing

Analysis of Epigenetic Age Predictors in Pain-Related Conditions.

Front Public Health 2020 9;8:172. Epub 2020 Jun 9.

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

Chronic pain prevalence is high worldwide and increases at older ages. Signs of premature aging have been associated with chronic pain, but few studies have investigated aging biomarkers in pain-related conditions. A set of DNA methylation (DNAm)-based estimates of age, called "epigenetic clocks," has been proposed as biological measures of age-related adverse processes, morbidity, and mortality. Read More

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http://dx.doi.org/10.3389/fpubh.2020.00172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296181PMC

A Case of Recurrent Painful Ophthalmoplegic Neuropathy.

Front Neurol 2020 4;11:440. Epub 2020 Jun 4.

Department of Neurology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Ophthalmoplegic migraine (OM) is characterized by recurrent episodes of headache with unilateral ophthalmoplegia due to paresis of cranial nerve III, IV, or VI. The recent revision to the International Headache Classification has reclassified it as recurrent painful ophthalmoplegic neuropathy (RPON). However, it is of note that the presentation of oculomotor nerve tumors may mimic RPON. Read More

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http://dx.doi.org/10.3389/fneur.2020.00440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287175PMC

The Mammalian Diving Response: Inroads to Its Neural Control.

Front Neurosci 2020 5;14:524. Epub 2020 Jun 5.

Department of Pharmacological and Physiological Science, School of Medicine, Saint Louis University, St. Louis, MO, United States.

The mammalian diving response (DR) is a remarkable behavior that was first formally studied by Laurence Irving and Per Scholander in the late 1930s. The DR is called such because it is most prominent in marine mammals such as seals, whales, and dolphins, but nevertheless is found in all mammals studied. It consists generally of breathing cessation (apnea), a dramatic slowing of heart rate (bradycardia), and an increase in peripheral vasoconstriction. Read More

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http://dx.doi.org/10.3389/fnins.2020.00524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290049PMC

Migraine start, course and features over the cycle of combined hormonal contraceptive users with menstrual migraine - temporal relation to bleeding and hormone withdrawal: a prospective diary-based study.

J Headache Pain 2020 Jun 24;21(1):81. Epub 2020 Jun 24.

Centre for Reproductive Medicine, St Bartholomew's Hospital, London, UK.

Background: Many studies have described the features of menstrually-related migraines (MRM) in the natural cycle and the efficacy of prevention. MRM in combined hormonal contraceptive (CHC) users has scarcely been researched. Estrogen and progestin withdrawal in CHC users are both more abrupt and from higher hormone levels compared with the natural cycle. Read More

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http://dx.doi.org/10.1186/s10194-020-01150-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315546PMC

The Efficacy of Botulinum Toxin in Pediatric Chronic Migraine: A Literature Review.

J Child Neurol 2020 Jun 24:883073820931256. Epub 2020 Jun 24.

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Aims: To conduct a review of the literature on the use of botulinum toxin for the treatment of pediatric chronic migraine.

Methods: A review of the literature was performed using EMBASE, PubMed, and Cochrane/Ovid. Using our inclusion and exclusion criteria, we targeted any study, published before April 2020, evaluating the efficacy of botulinum toxin in migraineurs younger than 18 years. Read More

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http://dx.doi.org/10.1177/0883073820931256DOI Listing

Evaluation of LY573144 (lasmiditan) in a preclinical model of medication overuse headache.

Cephalalgia 2020 Jun 24:333102420920006. Epub 2020 Jun 24.

Mayo Clinic, Scottsdale, AZ, USA.

Background: Medication overuse is a significant issue that complicates the treatment of headache disorders. The most effective medications for the acute treatment of migraine all have the capacity to induce medication overuse headache (MOH). Novel acute migraine-specific treatments are being developed. Read More

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http://dx.doi.org/10.1177/0333102420920006DOI Listing

Nose-to-brain delivery of sumatriptan-loaded nanostructured lipid carriers: preparation, optimization, characterization and pharmacokinetic evaluation.

J Pharm Pharmacol 2020 Jun 24. Epub 2020 Jun 24.

Pharmaceutical Sciences Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Objectives: Migraine is a neurological disorder with unilateral pulsatile headache which can affect the functions of sufferers. Migraineurs experience some undesirable symptoms such as pain, nausea, vomiting and in some cases auras which make the oral delivery non-selective. The lipid nanoparticles are considered as good carriers for nose-to-brain drug delivery. Read More

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http://dx.doi.org/10.1111/jphp.13316DOI Listing

Mechanistic Investigations Support Liver Safety of Ubrogepant.

Toxicol Sci 2020 Jun 24. Epub 2020 Jun 24.

NIHR-Wellcome Trust King's Clinical Research Facility, SLaM Biomedical Research Centre, King's College London, London, UK.

Small-molecule calcitonin gene-related peptide (CGRP) receptor antagonists have demonstrated therapeutic potential for the treatment of migraine. However, previously investigated CGRP receptor antagonists, telcagepant and MK-3207, were discontinued during clinical development because of concerns about drug-induced liver injury. A subsequent effort to identify novel CGRP receptor antagonists less likely to cause hepatotoxicity led to the development of ubrogepant. Read More

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http://dx.doi.org/10.1093/toxsci/kfaa093DOI Listing

Recent Advances in the Management of Migraine in Older Patients.

Drugs Aging 2020 Jul;37(7):463-468

Center for Neurologic Restoration, Headache Section, Cleveland Clinic Foundation, Neurological Institute, 9500 Euclid Ave, Desk C21, Cleveland, OH, 44195, USA.

Although the prevalence of migraine tends to decrease in the fifth to sixth decades of life, there are still a significant number of patients > 65 years of age who experience migraine or have new-onset migraine. Because these older patients are often excluded from clinical trials, there are fewer evidence-based treatment guidelines for them. Migraine treatment in the older population requires careful consideration of changes in medication metabolism and increased medical comorbidities. Read More

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http://dx.doi.org/10.1007/s40266-020-00776-9DOI Listing

Epileptic seizures.

Discoveries (Craiova) 2020 Jun 12;8(2):e110. Epub 2020 Jun 12.

CMH Lahore Medical College & Institute of Dentistry, Lahore, Pakistan.

Epilepsy is a condition marked by abnormal neuronal discharges or hyperexcitability of neurons with synchronicity and is recognized as a major public health concern. The pathology is categorized into three subgroups: acquired, idiopathic, and epilepsy of genetic or developmental origin. There are approximately 1000 associated genes and the role of γ-aminobutyric acid (GABA) mediated inhibition, as well as glutamate mediated excitation, forms the basis of pathology. Read More

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http://dx.doi.org/10.15190/d.2020.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305811PMC

Effect of age on pharmacokinetics, efficacy, and safety of galcanezumab treatment in adult patients with migraine: results from six phase 2 and phase 3 randomized clinical trials.

J Headache Pain 2020 Jun 23;21(1):79. Epub 2020 Jun 23.

Eli Lilly Italia, Sesto Fiorentino, Italy.

Background: Migraine clinical profile may change with age, making it necessary to verify that migraine treatments are equally safe and effective in older patients. These analyses evaluated the effects of patient age on the pharmacokinetics (PK), efficacy, and safety of galcanezumab for prevention of migraine.

Methods: Analyses included efficacy data from three double-blind phase 3 clinical trials: two 6-month studies in episodic migraine (EVOLVE-1, EVOLVE-2: N = 1773) and one 3-month study in chronic migraine (REGAIN:N = 1113). Read More

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http://dx.doi.org/10.1186/s10194-020-01148-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310276PMC

The Relationship between Education and Pain among Adults Aged 30-49 in the United States.

J Pain 2020 Jun 20. Epub 2020 Jun 20.

University at Buffalo, State University of New York.

Pain is a major health problem among US adults. Surprisingly little, however, is known about educational disparities in pain, especially among the nonelderly. In this study, we analyze disparities in pain across levels of educational attainment. Read More

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http://dx.doi.org/10.1016/j.jpain.2020.03.005DOI Listing

Evaluation of the Pharmacokinetic Interaction of Ubrogepant Coadministered With Sumatriptan and of the Safety of Ubrogepant With Triptans.

Headache 2020 Jun 23. Epub 2020 Jun 23.

Allergan plc, Madison, NJ, USA.

Objective: To evaluate the potential for pharmacokinetic interaction and the safety and tolerability when ubrogepant and sumatriptan are coadministered in a Phase 1 study in healthy participants, and to inform the safety and tolerability of ubrogepant alone and in combination with triptans in Phase 3 trials in participants with migraine.

Background: Calcitonin gene-related peptide is a potent vasodilatory neurotransmitter believed to play a key role in the pathophysiology of migraine. Ubrogepant (UBRELVY™) is a potent and selective antagonist of the human calcitonin gene-related peptide receptor approved for the acute treatment of migraine. Read More

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http://dx.doi.org/10.1111/head.13862DOI Listing

Network-guided search for genetic heterogeneity between gene pairs.

Bioinformatics 2020 Jun 23. Epub 2020 Jun 23.

Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.

Motivation: Correlating genetic loci with a disease phenotype is a common approach to improve our understanding of the genetics underlying complex diseases. Standard analyses mostly ignore two aspects, namely genetic heterogeneity and interactions between loci. Genetic heterogeneity, the phenomenon that different genetic markers lead to the same phenotype, promises to increase statistical power by aggregating low-signal variants. Read More

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http://dx.doi.org/10.1093/bioinformatics/btaa581DOI Listing

Neurochemical metabolite alterations of the occipital lobe in migraine without aura by proton magnetic resonance spectroscopy.

Neuroradiol J 2020 Jun 23:1971400920932793. Epub 2020 Jun 23.

Medical Physics Research Centre, Mashhad University of Medical Sciences, Iran.

Background: Migraine without aura is the most common type of migraine headache, accounting for about 80% of all migraines. The aim of the present investigation was to determine the neurochemical metabolite alterations in the occipital lobe of patients suffering from migraine without aura using proton magnetic resonance spectroscopy (H-MRS).

Methods: Fifteen patients suffering from migraine without aura with an occipital plaque and 16 healthy controls were included in this study. Read More

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http://dx.doi.org/10.1177/1971400920932793DOI Listing

Identifying patients with chronic pain who respond to acupuncture: results from an individual patient data meta-analysis.

Acupunct Med 2020 Jun 22:964528420920303. Epub 2020 Jun 22.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: In a recent individual patient data meta-analysis, acupuncture was found to be superior to sham and non-sham controls in patients with chronic pain. It has been suggested that a subgroup of patients has an exceptional response to acupuncture. We hypothesized the presence of exceptional acupuncture responders would lead to a different distribution of pain scores in acupuncture versus control groups, with the former being skewed to the right. Read More

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http://dx.doi.org/10.1177/0964528420920303DOI Listing

Alterations in Functional Connectivity During Different Phases of the Triggered Migraine Attack.

Headache 2020 Jun 22. Epub 2020 Jun 22.

Headache Group, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Objective: To understand the changes in functional connectivity between brain areas of potential importance in migraine during different phases of the attack.

Background: Migraine is a symptomatically heterogeneous disorder. Understanding the possible changes in brain function and, therefore, neurobiology during different phases of the migraine attack is important in developing disease biomarkers and advancing therapeutics. Read More

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http://dx.doi.org/10.1111/head.13865DOI Listing

Short-term Treatment of Migraine in Children and Adolescents.

JAMA Pediatr 2020 Jun 22. Epub 2020 Jun 22.

Pediatric Headache Center, Dell Medical School, Department of Neurology, University of Texas at Austin, Austin.

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http://dx.doi.org/10.1001/jamapediatrics.2020.1422DOI Listing

Vulvar pain: The revealing scenario of leading comorbidities in 1183 cases.

Eur J Obstet Gynecol Reprod Biol 2020 May 30;252:50-55. Epub 2020 May 30.

ASP 7, Ragusa Hospital, Italy.

Objectives: This study set out to investigate the epidemiological characteristics and comorbidities of chronic vulvar pain. Secondary goals were to identify the preferred approaches for managing vulvodynia in Italy.

Study Design: A cross-sectional study (the VuNet -Vulvodynia Network project) was performed in consecutive female patients with chronic vulvar pain attending 21 Italian medical centers (public hospitals, university clinics and private outpatient services) in the period December 2016 to November 2018. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.052DOI Listing

Testing rimegepant for migraine-time to revise the trial design?

Lancet 2020 06;395(10241):1901

Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Italy; Regional Epilepsy Centre, Great Metropolitan Hospital, Reggio Calabria 89100, Italy.

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http://dx.doi.org/10.1016/S0140-6736(20)30241-5DOI Listing

Testing rimegepant for migraine-time to revise the trial design? - Authors' reply.

Lancet 2020 06;395(10241):1901-1902

Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.

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http://dx.doi.org/10.1016/S0140-6736(20)30231-2DOI Listing

Maximizing placebo response in neurological clinical practice.

Int Rev Neurobiol 2020 9;153:71-101. Epub 2020 Jun 9.

Department of Neurology, Pitié-Salpêtrière Hospital, Sorbonne University, Assistance Publique Hôpitaux de Paris, Brain and Spine Institute, ICM, Inserm U 1127, CNRS UMR 7225, Paris, France. Electronic address:

The placebo effect is a widely recognized phenomenon in clinical research, with a negative perception that it could hide the "true" drug effect. In clinical care its positive potential to increase known drug effects has been neglected for too long. The placebo and nocebo responses have been described in many neurologic disorders such as Parkinson's, Huntington's and Alzheimer's diseases, restless leg syndrome, tics, essential tremor, dystonia, functional movement disorders, neuropathic pain, headaches, migraine, amyotrophic lateral sclerosis, myasthenia gravis, chronic inflammatory demyelinating polyneuropathy, multiple sclerosis and epilepsy. Read More

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http://dx.doi.org/10.1016/bs.irn.2020.04.003DOI Listing

Altered resting-state functional connectivity between subregions in the thalamus and cortex in migraine without aura.

Eur J Neurol 2020 Jun 19. Epub 2020 Jun 19.

East China Normal University, Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, School of Physics and Electronic Science, Shanghai, China.

Background: Migraine is a complex and disabling neurological disorder, and the exact neurological mechanisms remain unclear. Thalamus is considered the hub of the central processing and integration of nociceptive information, as well as the modulation of these processes.

Method: Forty-eight migraineurs without aura (MWoAs) during the interictal phase and 48 age- and sex-matched healthy controls (HCs) underwent resting-state fMRI scans. Read More

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http://dx.doi.org/10.1111/ene.14411DOI Listing

The Use of Botulinum Toxin in the Management of Headache Disorders.

Handb Exp Pharmacol 2020 Jun 20. Epub 2020 Jun 20.

Jefferson Headache Center, Thomas Jefferson University, Philadelphia, PA, USA.

Tremendous progress has been made in the past decades for the treatment of headache disorders. Chronic migraine is the most disabling type of headache and requires the use of acute and preventive medications, many of which are associated with adverse events that limit patient adherence. Botulinum toxin (BoNT) serotype A, a neurotoxin derived from certain strains of Clostridium, disrupts neuropeptide secretion and receptor translocation related to trigeminal nociception, thereby preventing pain sensitization through peripheral and possibly central mechanisms. Read More

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http://dx.doi.org/10.1007/164_2020_365DOI Listing

Headache in children with Sturge-Weber syndrome - Prevalence, associations and impact.

Eur J Paediatr Neurol 2020 May 28. Epub 2020 May 28.

Neurosciences Unit, Great Ormond Street Hospital NHS Foundation Trust, UK; Neurosciences Unit, UCL Institute of Child Health, UK.

Background: Sturge-Weber syndrome (SWS) is a congenital neurovascular disorder characterised by capillary-venous malformations involving the skin, brain and eye. Patients experience headache, however little is known about its characteristics or associations. We aimed to estimate prevalence, associations and the impact of headache in children with SWS. Read More

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http://dx.doi.org/10.1016/j.ejpn.2020.05.001DOI Listing
May 2020
1.934 Impact Factor

Neuronavigation based 10 sessions of repetitive transcranial magnetic stimulation therapy in chronic migraine: an exploratory study.

Neurol Sci 2020 Jun 15. Epub 2020 Jun 15.

Department of Physiology, Pain Research and TMS Lab, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Chronic migraine is a disease of altered cortical excitability. Repetitive transcranial magnetic stimulation provides a novel non-invasive method to target the nociceptive circuits in the cortex. Motor cortex is one such potential target. Read More

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http://dx.doi.org/10.1007/s10072-020-04505-3DOI Listing

Comorbidity is associated with disease activity in MS: Findings from the CombiRx trial.

Neurology 2020 Jun 17. Epub 2020 Jun 17.

Departments of Internal Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, CAN.

Objective: To determine whether comorbidity is associated with clinical (relapses, disability worsening) and MRI outcomes in multiple sclerosis (MS), we conducted a secondary analysis of the CombiRx clinical trial.

Methods: CombiRx compared interferon-beta-1a, glatiramer acetate and the combination of these agents. For participants eligible for evaluation of 6-month confirmed disability worsening, we used medical history, concomitant medications and adverse events to ascertain comorbidity status. Read More

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http://dx.doi.org/10.1212/WNL.0000000000010024DOI Listing

Impacts of migraine on the prevalence and clinical presentation of depression: A population-based study.

J Affect Disord 2020 Jul 29;272:215-222. Epub 2020 Apr 29.

Department of Neurology, Severance Hospital, Yonsei University, College of Medicine, Seoul, Korea. Electronic address:

Background: A close association has been reported between depression and migraine. However, information concerning the impacts of migraine on the clinical presentation and prevalence of depression in a population-based study is currently limited.

Methods: Data from the Korean Headache-Sleep Study, a nationwide survey about headache and sleep for adults aged 19-69 years were used. Read More

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http://dx.doi.org/10.1016/j.jad.2020.03.102DOI Listing

The locus of action of CGRPergic monoclonal antibodies against migraine: peripheral over central mechanisms.

CNS Neurol Disord Drug Targets 2020 Jun 18. Epub 2020 Jun 18.

Departamento de Farmacobiología, Cinvestav-Coapa, Czda. de los Tenorios 235, Col. Granjas-Coapa, Deleg. Tlalpan, 14330 Ciudad de México. Mexico.

Migraine is a complex neurovascular disorder characterized by attacks of moderate to severe unilateral headache, accompanied by photophobia or other neurological signs. Although an arsenal of antimigraine agents is currently available in the market, not all patients respond to them. As calcitonin gene-related peptide (CGRP) plays a key role in the pathophysiology of migraine, CGRP receptor antagonists (gepants) have been developed. Read More

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http://dx.doi.org/10.2174/1871527319666200618144637DOI Listing

Association between Toxoplasma gondii infection and headache: a systematic review and meta-analysis.

Infect Disord Drug Targets 2020 Jun 17. Epub 2020 Jun 17.

Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari. Iran.

Background: The impact of infectious agents, such as Toxoplasma gondii (T. gondii), on human behavior and mental disorders has recently attracted the attention of researchers. T. Read More

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http://dx.doi.org/10.2174/1871526520666200617135851DOI Listing

Endometriosis and migraine headache risk: a meta-analysis.

Women Health 2020 Jun 18:1-7. Epub 2020 Jun 18.

Autism Spectrum disorders Research Center, Hamadan University of Medical Sciences , Hamadan, Iran.

There is high prevalence of both migraine and endometriosis; however, the association between both is controversial. This systematic review evaluated the association between endometriosis and the risk of migraine headache. A search was done of the following international electronic bibliographic databases including: PubMed, Web of Science, and Scopus to May 2020. Read More

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http://dx.doi.org/10.1080/03630242.2020.1779905DOI Listing

Migraine presenting as isolated facial pain: A prospective clinical analysis of 58 cases.

Cephalalgia 2020 Jun 17:333102420933277. Epub 2020 Jun 17.

Orofacial Pain Service, Department of Oral Surgery, King's College Hospital NHS Foundation Trust, London, UK.

Background: Sparse evidence has detailed the clinical phenotype of migraine presenting as isolated facial pain. This was a prospective audit, part of our multidisciplinary facial pain service evaluation, aiming to phenotype patients with migraine presenting as isolated facial pain who attended our service between 2013 and 2018.

Results: Fifty-eight patients were diagnosed with migraine with isolated facial pain (F = 46, 79. Read More

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http://dx.doi.org/10.1177/0333102420933277DOI Listing

Sex Differences of Migraine: Results of a Nationwide Home-based Study in Turkey.

Noro Psikiyatr Ars 2020 Jun 26;57(2):126-130. Epub 2019 Sep 26.

Department of Neurology, Uludağ University, Uludağ School of Medicine, Bursa, Turkey.

Introduction: The prevalence of migraine was found to be more than three-fold higher in women as compared with men, and in addition to differences in prevalence rates, the characteristics and associated features might also differ between the sexes. The aim of this study was to compare sex-specific features of migraine and demographic parameters in a nationwide population-based study in Turkey.

Methods: Among 5323 subjects, a total of 871 patients who were diagnosed as having definite migraine according to the diagnostic criteria of the International Classification of Headache Disorders-III (ICHD-III) were included in our study. Read More

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http://dx.doi.org/10.29399/npa.23240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285639PMC