32,620 results match your criteria Migraine Headache


Onset of efficacy and duration of response of galcanezumab for the prevention of episodic migraine: a post-hoc analysis.

J Neurol Neurosurg Psychiatry 2019 Apr 19. Epub 2019 Apr 19.

Eli Lilly and Company, Indianapolis, Indiana, USA.

Background And Objective: As new migraine prevention treatments are developed, the onset of a preventive effect, how long it is maintained and whether patients initially non-responsive develop clinically meaningful responses with continued treatment can be assessed.

Methods: Analyses were conducted post-hoc of a double-blind, placebo-controlled, phase II-a study in patients with episodic migraine receiving galcanezumab 150 mg or placebo biweekly for 12 weeks ( 13:885, 2014). The number of migraine headache days per week, and onset of efficacy measured as the first week galacanezumab separated from placebo were determined. Read More

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http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2018-320242
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http://dx.doi.org/10.1136/jnnp-2018-320242DOI Listing
April 2019
1 Read

Decompression Hemicraniectomy for Refractory Intracranial Hypertension in Reversible Cerebral Vasoconstriction Syndrome.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):355-359

Division of Neurocritical Care, Cerebrovascular Center, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Reversible cerebral vasoconstriction syndrome (RCVS) is a disorder of dysregulation of cerebrovascular tone resulting in transient segmental vasoconstriction which resolves in 1-3 months. Cerebral edema is an underrecognized complication in RCVS. It is likely multifactorial. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_334_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454955PMC

Changes in MIDAS, Perceived Stress, Frontalis Muscle Activity and Non-Steroidal Anti-Inflammatory Drugs Usage in Patients with Migraine Headache without Aura following Ayurveda and Yoga Compared to Controls: An Open Labeled Non-Randomized Study.

Ann Neurosci 2018 Dec 11;25(4):250-260. Epub 2018 Sep 11.

Division of Yoga and Life Sciences, Swami Vivekananda Yoga Anusandhana Samsthana (S-VYASA) A Deemed to be University, Bengaluru, India.

Background: There has been a significant increase in the use of complementary and integrative medicine to provide long-term healing solutions in migraine headache patients. Knowing the limitations of conventional medical approach, the present study evaluated the influence of two Indian traditional systems of medicine on migraine-related disability, autonomic variables, perceived stress, and muscle activity in patients with migraine headache without aura.

Methods: Thirty subjects recruited to the Ayurveda and Yoga (AY) group underwent traditional (Bio-purification) using therapeutic Purgation followed by yoga therapy, while 30 subjects of control (CT) group continued on symptomatic treatment (non-steroidal anti-inflammatory drugs [NSAID's]) for 90 days. Read More

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http://dx.doi.org/10.1159/000492269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470355PMC
December 2018
1 Read

The diagnostic accuracy of headache measurement instruments: A systematic review and meta-analysis focusing on headaches associated with musculoskeletal symptoms.

Cephalalgia 2019 Apr 18:333102419840777. Epub 2019 Apr 18.

6 University Medical Center Utrecht, Utrecht University, Department of Oral-Maxillofacial Surgery and Special Dental Care, Utrecht, the Netherlands.

Aim: To systematically review the available literature on the diagnostic accuracy of questionnaires and measurement instruments for headaches associated with musculoskeletal symptoms.

Design: Articles were eligible for inclusion when the diagnostic accuracy (sensitivity/specificity) was established for measurement instruments for headaches associated with musculoskeletal symptoms in an adult population. The databases searched were PubMed (1966-2018), Cochrane (1898-2018) and Cinahl (1988-2018). Read More

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http://dx.doi.org/10.1177/0333102419840777DOI Listing

Relaxation training for management of paediatric headache: A rapid review.

Paediatr Child Health 2019 May 7;24(2):103-114. Epub 2019 Feb 7.

Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta.

The objective of this review was to assess the evidence on relaxation training for management of paediatric headaches. Our methodology was a rapid review of English-language peer reviewed published literature focused on studies evaluating relaxation training as a primary or adjunct management option for headache in a paediatric population (0 to 18 years of age). Seven studies involving 571 children were included in the review. Read More

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https://academic.oup.com/pch/article/24/2/103/5308619
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http://dx.doi.org/10.1093/pch/pxy157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462122PMC
May 2019
1 Read

Migraine-like Headache after Transseptal Puncture for Catheter Ablation: A Case Report and Review of the Literature.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center, Japan.

Catheter ablation for atrial fibrillation creates an iatrogenic atrial septal defect by transseptal puncture, which may produce a transient right-to-left shunt. We encountered a 44-year-old man who presented with de novo migraine-like headache after cryoballoon ablation for atrial fibrillation. On reviewing the literature, we found additional cases in which migraine-like headache occurred within one week after the procedure and spontaneously within three months. Read More

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http://dx.doi.org/10.2169/internalmedicine.2519-18DOI Listing
April 2019
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Erenumab in chronic migraine: Patient-reported outcomes in a randomized double-blind study.

Neurology 2019 Apr 17. Epub 2019 Apr 17.

From the Department of Neurology (R.B.L.), Albert Einstein College of Medicine, Bronx, New York; Geisel School of Medicine at Dartmouth (S.J.T.), Hanover, NH; Department of Neurology (U.R.), Charité Universitätsmedizin Berlin, Germany; Jefferson Headache Center (S.S.), Thomas Jefferson University, Philadelphia, PA; Sutter Health (W.F.S.), Walnut Creek, CA; and Amgen Inc. (J.N., D.K.L., P.D., S.C., D.D.M., R.L.), Thousand Oaks, CA.

Objective: To determine the effect of erenumab, a human monoclonal antibody targeting the calcitonin gene-related peptide receptor, on health-related quality of life (HRQoL), headache impact, and disability in patients with chronic migraine (CM).

Methods: In this double-blind, placebo-controlled study, 667 adults with CM were randomized (3:2:2) to placebo or erenumab (70 or 140 mg monthly). Exploratory endpoints included migraine-specific HRQoL (Migraine-Specific Quality-of-Life Questionnaire [MSQ]), headache impact (Headache Impact Test-6 [HIT-6]), migraine-related disability (Migraine Disability Assessment [MIDAS] test), and pain interference (Patient-Reported Outcomes Measurement Information System [PROMIS] Pain Interference Scale short form 6b). Read More

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http://dx.doi.org/10.1212/WNL.0000000000007452DOI Listing

Erenumab in chronic migraine with medication overuse: Subgroup analysis of a randomized trial.

Neurology 2019 Apr 17. Epub 2019 Apr 17.

From the Geisel School of Medicine at Dartmouth (S.J.T.), Hanover, NH; Department of Neurology (H.-C.D.), University of Duisburg-Essen, Germany; Department of Neurology (M.A.), Danish Headache Center, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Neurology (J.L.B.), Vanderbilt University School of Medicine; Nashville Neuroscience Group (J.L.B.), TN; Neurology and Neurotherapeutics and Ophthalmology (D.I.F.), University of Texas Southwestern Medical Center, Dallas; Department of Neurology (U.R.), Charité Universitätsmedizin Berlin, Germany; and Amgen Inc (S.C., J.N., D.K.L., R.A.L., D.D.M.), Thousand Oaks, CA.

Objective: To determine the effect of erenumab, a human anti-calcitonin gene-related peptide receptor monoclonal antibody, in patients with chronic migraine and medication overuse.

Methods: In this double-blind, placebo-controlled study, 667 adults with chronic migraine were randomized (3:2:2) to placebo or erenumab (70 or 140 mg), stratified by region and medication overuse status. Data from patients with baseline medication overuse at baseline were used to assess changes in monthly migraine days, acute migraine-specific medication treatment days, and proportion of patients achieving ≥50% reduction from baseline in monthly migraine days. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007497DOI Listing
April 2019
1 Read

Therapeutic novelties in migraine: new drugs, new hope?

J Headache Pain 2019 Apr 17;20(1):37. Epub 2019 Apr 17.

Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Background: In the past decade, migraine research has identified novel drug targets. In this review, we discuss recent data on emerging anti-migraine therapies.

Main Body: The development of ditans, gepants and anti-calcitonin gene-related peptide monoclonal antibodies for the treatment of migraine is one of the greatest advances in the migraine field. Read More

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https://thejournalofheadacheandpain.biomedcentral.com/articl
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http://dx.doi.org/10.1186/s10194-019-0974-3DOI Listing
April 2019
1 Read

CADASIL with Atypical Clinical Symptoms, Magnetic Resonance Imaging, and Novel Mutations: Two Case Reports and a Review of the Literature.

J Mol Neurosci 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurology, Celal Bayar University, 45000, Manisa, Turkey.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary microangiopathy with adult onset caused by a missense mutation in the NOTCH3 gene in chromosome 19p13. It presents with autosomal dominant arteriopathy, subcortical infarctions, and leukoencephalopathy. Its common clinical presentations are seen as recurrent strokes, migraine or migraine-like headaches, progressive dementia, pseudobulbar paralysis, and psychiatric conditions. Read More

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http://dx.doi.org/10.1007/s12031-019-01313-zDOI Listing

Effect of adjunctive intermittent theta-burst repetitive transcranial magnetic stimulation as a prophylactic treatment in migraine patients: A double-blind sham-controlled study.

Indian J Psychiatry 2019 Mar-Apr;61(2):139-145

Department of Psychiatry, Centre for Cognitive Neurosciences, Central Institute of Psychiatry, Ranchi, Jharkhand, India.

Background: The left dorsolateral prefrontal cortex (DLPFC) seems to exert a bilateral control of chronic pain states such as migraine. Repetitive transcranial magnetic stimulation (rTMS) is known to modulate brain excitability, neurotransmitters, and endogenous opioids involved in pathophysiology of migraine.

Aim: This study was designed to assess the efficacy of adjunctive intermittent theta-burst stimulation (iTBS) to the left DLPFC, as a prophylactic treatment in migraine. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_472_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425789PMC
April 2019
1 Read

Migraine in patients with fibromyalgia and outcomes of greater occipital nerve blockage.

Clin Neurol Neurosurg 2019 Apr 9;181:54-57. Epub 2019 Apr 9.

Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Ankara, Turkey.

Objectives: The aim of this study is to evaluate the efficacy of greater occipital nerve (GON) blockage in patients with migraine and fibromyalgia (FM) comorbidity.

Patients And Method: 20 patients who were diagnosed as FM according to 2010 American College of Rheumatology (ACR) diagnostic criteria and migraine according to International Classification of Headache Disorers II criteria and did not recieve any medication or GON block for both disorders were included for the study. GON blocks were repeated every week in the first month and repeated montly for the following 2 months. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467193009
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http://dx.doi.org/10.1016/j.clineuro.2019.04.004DOI Listing
April 2019
2 Reads

The Efficacy and Safety of Prochlorperazine in Patients With Acute Migraine: A Systematic Review and Meta-Analysis.

Headache 2019 Apr 16. Epub 2019 Apr 16.

Department of Emergency Medicine, Orthopedic Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Objective: The aim of this review was to evaluate the efficacy and safety of prochlorperazine (PCP) in patients with acute migraine headache in the emergency department (ED).

Methods: Electronic databases (Medline, Scopus, Web of Science, and Cochrane) were searched for randomized clinical trials that investigated the effect of PCP on headache relief. The outcomes were the number of patients without headache or with reduced headache severity, the number of adverse events, and the need for rescue analgesia. Read More

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http://dx.doi.org/10.1111/head.13527DOI Listing
April 2019
2 Reads

[Effect of fresh Gastrodia elata on gut microbiota in mice].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(5):1004-1009

National Resource Center for Chinese Materia Medical,China Academy of Chinese Medical Sciences Beijing 100700,China.

Gastrodia elata B1.,a traditional Chinese medicine,was frequently applied as a cure for headache or migraine. Its effects include suppressing hyperactive liver,calming endogenous wind,dredging collateralsand relieving spasm. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.2019.0018
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http://dx.doi.org/10.19540/j.cnki.cjcmm.2019.0018DOI Listing
March 2019
1 Read

Pathophysiological Mechanisms in Migraine and the Identification of New Therapeutic Targets.

CNS Drugs 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical and Experimental Research, Glostrup Research Institute, Copenhagen University Hospital, Rigshospitalet-Glostrup, Nordstjernevej 42, 2600, Glostrup, Denmark.

Migraine is a strongly disabling disease characterized by a unilateral throbbing headache lasting for up to 72 h for each individual attack. There have been many theories on the pathophysiology of migraine throughout the years. Currently, the neurovascular theory dominates, suggesting clear involvement of the trigeminovascular system. Read More

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http://link.springer.com/10.1007/s40263-019-00630-6
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http://dx.doi.org/10.1007/s40263-019-00630-6DOI Listing
April 2019
1 Read

PACAP-38 and PACAP(6-38) Degranulate Rat Meningeal Mast Cells the Orphan MrgB-Receptor.

Front Cell Neurosci 2019 28;13:114. Epub 2019 Mar 28.

Glostrup Research Institute, Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Copenhagen, Denmark.

Infusion of pituitary adenylate cyclase activating peptide-38 (PACAP-38) provokes migraine attacks in migraineurs and headache in non-migraineurs. Adverse events like long-lasting flushing and heat sensation can be terminated with oral antihistamine treatment, indicating the involvement of mast cell activation after PACAP-infusion. Degranulation of rat peritoneal mast cells was provoked by several isoforms of PACAP previously unknown receptor pharmacology. Read More

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http://dx.doi.org/10.3389/fncel.2019.00114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447718PMC
March 2019
4 Reads

CGRP and the Trigeminal System in Migraine.

Headache 2019 Apr 14. Epub 2019 Apr 14.

Eli Lilly and Company, Indianapolis, IN, USA.

Objective: The goal of this narrative review is to provide an overview of migraine pathophysiology, with an emphasis on the role of calcitonin gene-related peptide (CGRP) within the context of the trigeminovascular system.

Background: Migraine is a prevalent and disabling neurological disease that is characterized in part by intense, throbbing, and unilateral headaches. Despite recent advances in understanding its pathophysiology, migraine still represents an unmet medical need, as it is often underrecognized and undertreated. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/head.13529
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http://dx.doi.org/10.1111/head.13529DOI Listing
April 2019
2 Reads

Acute withdrawal and botulinum toxin A in chronic migraine with medication overuse: a double-blind randomized controlled trial.

Brain 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands.

Botulinum toxin A (BTA) is widely used as treatment of chronic migraine. Efficacy in studies, however, was only modest and likely influenced by unblinding due to BTA-induced removal of forehead wrinkles. Moreover, most study participants were overusing acute headache medications and might have benefitted from withdrawal. Read More

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https://academic.oup.com/brain/advance-article/doi/10.1093/b
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http://dx.doi.org/10.1093/brain/awz052DOI Listing
April 2019
4 Reads

Efficacy and safety of erenumab (AMG334) in episodic migraine patients with prior preventive treatment failure: A subgroup analysis of a randomized, double-blind, placebo-controlled study.

Cephalalgia 2019 Apr 13:333102419835459. Epub 2019 Apr 13.

7 Amgen Inc., Thousand Oaks, CA, USA.

Background: Erenumab was effective and well tolerated in a pivotal clinical trial of episodic migraine that included subjects both naïve to, and those who had failed, previous preventives. Here we evaluated the efficacy and safety of erenumab (70 mg or 140 mg) versus placebo in the subgroup of patients who had previously failed preventive treatment(s): ≥1 or ≥2 prior failed migraine preventive categories, and in patients who had never failed.

Methods: Prespecified subgroup analyses evaluated change from baseline to months 4-6 (the primary endpoint of the blinded study phase) in monthly migraine days, achievement of ≥50% and ≥75% reduction in monthly migraine days, and change from baseline in acute migraine-specific medication days. Read More

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http://dx.doi.org/10.1177/0333102419835459DOI Listing
April 2019
1 Read

Cyclic vomiting syndrome and benign paroxysmal torticollis are associated with a high risk of developing primary headache: A longitudinal study.

Cephalalgia 2019 Apr 13:333102419844542. Epub 2019 Apr 13.

1 Headache Center, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Background And Aim: Episodic syndromes that may be associated with migraine are a group of disorders affecting patients with migraine or with an increased risk of presenting it, and likely represent an early life expression of migraine. Cyclic vomiting syndrome and benign paroxysmal torticollis are well characterized and represent a frequent cause of request for specialist consultations. The aim of this study is to longitudinally assess the rate of headache in patients presenting with cyclic vomiting syndrome and benign paroxysmal torticollis during infancy, and to define the main clinical features of the disorder. Read More

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http://dx.doi.org/10.1177/0333102419844542DOI Listing
April 2019
2 Reads

Headaches and sleep problems in US adolescents: Findings from the National Comorbidity Survey - Adolescent Supplement (NCS-A).

Cephalalgia 2019 Apr 13:333102419835466. Epub 2019 Apr 13.

1 Genetic Epidemiology Branch, National Institute of Mental Health, Bethesda, MD, USA.

Background: There is limited research on the association of sleep problems with International Classification of Headache Disorders (ICHD-II)-defined headache subtypes in youth, particularly from community-based samples. This cross-sectional study examines the associations of sleep patterns, symptoms and disorders with specific headache subtypes among adolescents from the general population of the United States.

Methods: The sample includes 10,123 adolescents in the National Comorbidity Survey - Adolescent Supplement, a face-to-face survey of adolescents aged 13-18 years in the continental USA. Read More

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http://dx.doi.org/10.1177/0333102419835466DOI Listing
April 2019
2 Reads

The Association of Manual Muscle Tests and Treatment Outcomes With Headache and Cranial Dysfunctions: A Retrospective Case Series Report.

Altern Ther Health Med 2018 Nov;24(6):8-21

Background: This study examine whether there is an interrelationship between cranio-sacral dysfunctions and the muscle inhibitions found in the muscles attaching to the skull in patients with headaches.

Primary Study Objective: To present a retrospective case series report assessing the prevalence of positive manual muscle tests (MMTs) in the assessment and management of adults with headache and cervico-cranial dysfunctions and to present patient outcomes pre- and posttreatment.

Methods/design: Fifty-two patient files with headache (HA) (48 females, 4 males) were retrospectively examined. Read More

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November 2018

Migraine is not the most common comorbidity in hidradenitis suppurativa patients.

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Department of dermatology, allergology and venereology, Helsinki University Central Hospital, Helsinki, Finland.

Migraine is the most common primary headache syndrome worldwide, affecting approximately 12% of the Caucasian population [1]. Migraine has been associated with various cardiovascular [2] and psychiatric co-morbidities [3], more recently inflammatory disorders such as psoriasis [4] and inflammatory bowel disease [5]. As hidradenitis suppurativa (HS) shares common comorbidity risks, we sought to investigate the possible link between migraine and HS. Read More

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http://dx.doi.org/10.1111/jdv.15625DOI Listing
April 2019
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Signs and symptoms of the postictal period in epilepsy: A systematic review and meta-analysis.

Epilepsy Behav 2019 Apr 9;94:243-251. Epub 2019 Apr 9.

Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, 1195 1403-29 Street, NW Calgary, AB T2N 2T9, Canada; Icahn School of Medicine at Mount Sinai, Department of Neurology, One Gustave L. Levy Place, Box 1137, New York, NY 10029, USA; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, 3D10 - 3280 Hospital Drive NW, Calgary, AB T2N 4Z6, Canada; Hotchkiss Brain Institute, University of Calgary, Room 1A10 - 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada. Electronic address:

Objective: The postictal period has many physical, behavioral, and cognitive manifestations associated with it. These signs and symptoms are common, can be quite debilitating, and can have a continued impact long after the seizure has ended. The purpose of this systematic review was to quantify the occurrence of postictal signs and symptoms, along with their frequency and duration in persons with epilepsy. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.03.014DOI Listing
April 2019
3 Reads
2.257 Impact Factor

The effects of cerebral curvature on cortical spreading depression.

J Theor Biol 2019 Apr 9;472:11-26. Epub 2019 Apr 9.

Department of Mechanical Engineering, University of Canterbury, New Zealand.

Neuronal activity evokes a localised increase in cerebral blood flow through neurovascular coupling (NVC), a communication system between a group of cells known as a neurovascular unit (NVU). Dysfunctional NVC can lead to pathologies such as cortical spreading depression (CSD), characterised by a slowly propagating wave of neuronal depolarisation and high extracellular potassium (K) levels. CSD is associated with several neurological disorders such as migraine, stroke, and traumatic brain injury. Read More

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http://dx.doi.org/10.1016/j.jtbi.2019.04.006DOI Listing
April 2019
4 Reads

Treatment patterns and predictors of costs among patients with migraine: evidence from the United States Medical Expenditure Panel Survey.

J Med Econ 2019 Apr 12. Epub 2019 Apr 12.

a Eli Lilly and Company , Indianapolis , IN , USA.

Aim: Within a treated migraine population, to evaluate if the subgroup meeting criteria for high disease-specific total costs is significantly different than the subgroup with medium and/or low-costs, and to identify the associated risk factors.

Methods: Data from the Household Component of Medical Expenditure Panel Survey (MEPS-HC, 2008-2012), a nationally representative survey of noninstitutionalized civilians in USA, were analyzed. Key inclusion criteria were migraine diagnosis (ICD-9 code: 346. Read More

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http://dx.doi.org/10.1080/13696998.2019.1607358DOI Listing

Safety and Tolerability of Fremanezumab for the Prevention of Migraine: A Pooled Analysis of Phases 2b and 3 Clinical Trials.

Headache 2019 Apr 12. Epub 2019 Apr 12.

Teva Pharmaceuticals, Frazer, PA, USA.

Objective: Presentation of pooled analysis of safety data for fremanezumab in patients with chronic (CM) or episodic migraine (EM) from 4 placebo-controlled phase 2b and phase 3 studies.

Background: There is a need for an effective, safe, and well-tolerated preventive therapy that specifically targets the pathophysiology of migraine to reduce the frequency and severity of migraine attacks in patients with CM or EM who experience 4 or more migraine days per month. Fremanezumab is a fully humanized monoclonal antibody that targets calcitonin gene-related peptide, a neuropeptide involved in the pathophysiology of migraine. Read More

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http://dx.doi.org/10.1111/head.13534DOI Listing
April 2019
1 Read

Somatic comorbidity in Polish patients with epilepsy.

Pol Arch Intern Med 2019 Apr 12. Epub 2019 Apr 12.

INTRODUCTION A range of somatic and psychiatric disorders occurs frequently in patients with epilepsy (PWE), which adds to the burden of epilepsy. OBJECTIVES To estimate the prevalence and risk factors of somatic comorbidities and  analyze the extent of somatic co-medication in adult PWE. PATIENTS AND METHODS This study involved PWE treated in university epilepsy clinic. Read More

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http://dx.doi.org/10.20452/pamw.14794DOI Listing
April 2019
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Age- and sex-specific first health care use for migraine in 2016 in children and adolescents from prospectively collected health insurance data in Germany.

Cephalalgia 2019 Apr 11:333102419844543. Epub 2019 Apr 11.

2 Department of Neurology, Ludwig-Maximilians-University Munich, Munich, Germany.

Background: Migraine in children and adolescents is associated with significant disability and a high risk of persistence into adulthood.

Objective: Data on migraine incidence in children and adolescents are few and relatively coarse. To tailor interventions starting shortly after disease onset, detailed information on age- and sex-specific incidence of migraine in children and adolescents is needed. Read More

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http://dx.doi.org/10.1177/0333102419844543DOI Listing
April 2019
1 Read

Potential Protective Mechanisms of Ketone Bodies in Migraine Prevention.

Nutrients 2019 Apr 10;11(4). Epub 2019 Apr 10.

Division of Paediatric Neurology, University Children's Hospital Basel (UKBB), University of Basel, 4056 Basel, Switzerland.

An increasing amount of evidence suggests that migraines are a response to a cerebral energy deficiency or oxidative stress levels that exceed antioxidant capacity. The ketogenic diet (KD), a diet mimicking fasting that leads to the elevation of ketone bodies (KBs), is a therapeutic intervention targeting cerebral metabolism that has recently shown great promise in the prevention of migraines. KBs are an alternative fuel source for the brain, and are thus likely able to circumvent some of the abnormalities in glucose metabolism and transport found in migraines. Read More

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http://dx.doi.org/10.3390/nu11040811DOI Listing

Visual input drives increased occipital responsiveness and harmonized oscillations in multiple cortical areas in migraineurs.

Neuroimage Clin 2019 Apr 3;23:101815. Epub 2019 Apr 3.

Department of Systems Neuroscience, University Medical Center Eppendorf, Hamburg, Germany. Electronic address:

Migraineurs are hypersensitive for most sensory domains like visual, auditory or somatosensory processing even outside of attacks. This behavioral peculiarity is mirrored by findings of cortical hyper-responsivity already in the interictal state. Using repetitive visual stimulation to elicit steady state visually evoked potentials (SSVEP) in 30 interictal episodic migraineurs and 30 controls we show hyper-responsivity of the visual cortex in the migraineurs. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458451PMC

Anatomical study of the supraorbital and supratrochlear nerves: a new classification and application to understanding some migraine headaches.

Clin Anat 2019 Apr 11. Epub 2019 Apr 11.

Seattle Science Foundation, Seattle, WA, USA.

Introduction: The frontal nerve is the largest branch of the ophthalmic nerve. This nerve gives rise to two terminal branches, the supraorbital (SON) and supratrochlear nerves (STN). To our knowledge, there are no reports describing the detailed proximal course of these nerves while inside the orbit. Read More

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http://dx.doi.org/10.1002/ca.23384DOI Listing

Comment on "Chronic Migraine - Evolution of the Concept and Clinical Implications".

Headache 2019 Apr;59(4):623

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/head.13518
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http://dx.doi.org/10.1111/head.13518DOI Listing
April 2019
2 Reads

Choose Wisely: Adapt the Classification Characteristic for Migraine Trigger Points.

Authors:
Hossein Ansari

Headache 2019 Apr;59(4):621-622

Department of Neuroscience, University of California, San Diego, San Diego, CA, USA.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/head.13521
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http://dx.doi.org/10.1111/head.13521DOI Listing
April 2019
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The American Headache Society's Position Statement on Integrating New Migraine Treatments into Clinical Practice - Comments.

Headache 2019 Apr;59(4):629

The David Geffen School of Medicine at UCLA in Los Angeles, CA, USA.

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http://dx.doi.org/10.1111/head.13496DOI Listing

Misused and Misleading: "100% Response Rate" to Galcanezumab in Patients With Episodic Migraine.

Headache 2019 Apr;59(4):626

Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, University of Copenhagen, Glostrup, Denmark.

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http://dx.doi.org/10.1111/head.13515DOI Listing

The Impact of Spinal Manipulation on Migraine Pain and Disability: A Systematic Review and Meta-Analysis.

Headache 2019 Apr 14;59(4):532-542. Epub 2019 Mar 14.

Division of Preventive Medicine, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.

Background: Several small studies have suggested that spinal manipulation may be an effective treatment for reducing migraine pain and disability. We performed a systematic review and meta-analysis of published randomized clinical trials (RCTs) to evaluate the evidence regarding spinal manipulation as an alternative or integrative therapy in reducing migraine pain and disability.

Methods: PubMed and the Cochrane Library databases were searched for clinical trials that evaluated spinal manipulation and migraine-related outcomes through April 2017. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/head.13501
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http://dx.doi.org/10.1111/head.13501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461372PMC
April 2019
4 Reads

Toward a Philosophy of Migraine.

Authors:
Robert P Cowan

Headache 2019 Apr;59(4):481-483

Department of Neurology and Neuroscience, Stanford University School of Medicine, Palo Alto, CA, USA.

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http://dx.doi.org/10.1111/head.13517DOI Listing

Dopamine-beta-hydroxylase 19-bp insertion/deletion polymorphism affects medication overuse in patients with chronic migraine.

Neurol Sci 2019 Apr 10. Epub 2019 Apr 10.

Biobanca InterIstituzionale Multidisciplinare, IRCCS San Raffaele Pisana, Rome, Italy.

Dopamine-beta-hydroxylase (DBH) enzyme activity is modulated at the genetic level by the presence of several polymorphisms. Among these, the 19-bp insertion/deletion (I/D) polymorphism (rs72393728/rs141116007) was investigated in several genetic association studies for its correlation with the susceptibility to develop episodic migraine, but conflicting results were achieved. In the present study we analyzed this genetic variant in a carefully characterized population of migraineurs encompassing both episodic and chronic migraine (with and without medication overuse) with the aim to perform a replication study and verify any possible correlation with migraine endophenotypes. Read More

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http://dx.doi.org/10.1007/s10072-019-03865-9DOI Listing

A Neuroscience Perspective of Physical Treatment of Headache and Neck Pain.

Front Neurol 2019 26;10:276. Epub 2019 Mar 26.

Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerpen, Belgium.

The most prevalent primary headaches tension-type headache and migraine are frequently associated with neck pain. A wide variety of treatment options is available for people with headache and neck pain. Some of these interventions are recommended in guidelines on headache: self-management strategies, pharmacological and non-pharmacological interventions. Read More

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http://dx.doi.org/10.3389/fneur.2019.00276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443880PMC

TRP Channels and Migraine: Recent Developments and New Therapeutic Opportunities.

Pharmaceuticals (Basel) 2019 Apr 9;12(2). Epub 2019 Apr 9.

School of Behavioral and Brain Sciences, Center for Advanced Pain Studies, The University of Texas at Dallas, Richardson, TX 75080, USA.

Migraine is the second-most disabling disease worldwide, and the second most common neurological disorder. Attacks can last many hours or days, and consist of multiple symptoms including headache, nausea, vomiting, hypersensitivity to stimuli such as light and sound, and in some cases, an aura is present. Mechanisms contributing to migraine are still poorly understood. Read More

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https://www.mdpi.com/1424-8247/12/2/54
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http://dx.doi.org/10.3390/ph12020054DOI Listing
April 2019
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An Integrative Cognitive Behavioral Therapy Program for Adults With Migraine: A Feasibility Study.

Headache 2019 Apr 10. Epub 2019 Apr 10.

Department of Psychology, University of Mainz, Mainz, Germany.

Objective: To present a novel cognitive behavioral therapy program that was developed exclusively for adults with migraine, and to assess the feasibility of this program.

Background: Unlike previous efforts, we combined different approaches of behavioral therapy into one program: relaxation therapy, cognitive behavioral therapy, trigger management.

Methods: The treatment program consists of 7 sessions (including psychoeducation, lifestyle counseling, coping with fear of attacks, trigger management, and stress management). Read More

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http://dx.doi.org/10.1111/head.13532DOI Listing

Short Term Oral Methylergonovine Maleate Prophylaxis for Status Migrainosus. Case Series and Review of Literature.

Front Neurol 2019 20;10:201. Epub 2019 Mar 20.

Headache Center, Johns Hopkins Medicine, Baltimore, MD, United States.

Intravenous dihydroergotamine (DHE) is frequently used during inpatient hospitalizations or outpatient infusion therapies for 3-5 days in order to break the continuous cycle of status migrainosus. We tried a short term 7 days prophylaxis of oral methylergonovine after discharge in order to prevent status migrainosus relapse and extend the therapeutic benefit from IV DHE. Patients were diagnosed with status migrainosus in clinic setting based on the ICHD-III criteria. Read More

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http://dx.doi.org/10.3389/fneur.2019.00201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440365PMC

Migraine in the Young Brain: Adolescents vs. Young Adults.

Front Hum Neurosci 2019 22;13:87. Epub 2019 Mar 22.

Department of Anesthesiology, Perioperative and Pain Medicine, Center for Pain and the Brain, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.

Migraine is a disease that peaks in late adolescence and early adulthood. The aim of this study was to evaluate age-related brain changes in resting state functional connectivity (rs-FC) in migraineurs vs. age-sex matched healthy controls at two developmental stages: adolescence vs. Read More

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http://dx.doi.org/10.3389/fnhum.2019.00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438928PMC

ALPK1 missense pathogenic variant in five families leads to ROSAH syndrome, an ocular multisystem autosomal dominant disorder.

Genet Med 2019 Apr 10. Epub 2019 Apr 10.

Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA.

Purpose: To identify the molecular cause in five unrelated families with a distinct autosomal dominant ocular systemic disorder we called ROSAH syndrome due to clinical features of retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache.

Methods: Independent discovery exome and genome sequencing in families 1, 2, and 3, and confirmation in families 4 and 5. Expression of wild-type messenger RNA and protein in human and mouse tissues and cell lines. Read More

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http://www.nature.com/articles/s41436-019-0476-3
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http://dx.doi.org/10.1038/s41436-019-0476-3DOI Listing
April 2019
4 Reads
7.329 Impact Factor

The role of obesity and vitamin D deficiency in primary headaches in childhood.

Acta Neurol Belg 2019 Apr 8. Epub 2019 Apr 8.

Division of Neonatology, Abant İzzet Baysal University, 14030, Bolu, Turkey.

This study evaluates the role of obesity, overweight and vitamin D deficiency in primary headaches in childhood. This retrospective observational study included pediatric patients aged 5-17 years admitted to the pediatric neurology clinic with headaches between January 2015 and August 2018 and diagnosed with primary headache based on ICHD III-beta criteria. The control group consisted of healthy children without headache admitted to the pediatric outpatient clinic for check-ups before engaging in athletic or school activities. Read More

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http://dx.doi.org/10.1007/s13760-019-01134-2DOI Listing

Vestibular migraine treatment and prevention.

Authors:
A Lapira

HNO 2019 Apr 8. Epub 2019 Apr 8.

St James & Capua Hospitals, George Borg Olivier St, SLM 1807, Sliema, Malta.

Vestibular migraine probably represents the second most common cause of vertigo after benign positional vertigo, by far exceeding Ménière disease. There are still relatively few published reports on vestibular migraine management, despite its enormous importance in daily practice. In 2003 the first clinical definition of vestibular migraine was proposed. Read More

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http://link.springer.com/10.1007/s00106-019-0661-3
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http://dx.doi.org/10.1007/s00106-019-0661-3DOI Listing
April 2019
6 Reads

Manual therapy for chronic migraine: a pragmatic randomised controlled trial study protocol.

Chiropr Man Therap 2019 27;27:11. Epub 2019 Mar 27.

1Bournemouth University, Royal London House, Christchurch Road, Bournemouth, BH1 3LT UK.

Introduction: Chronic migraine is a largely refractory condition affecting between 1 and 2.2% of the overall population worldwide, with females more affected than males. There are also high health and socioeconomic costs associated both for the individual and society. Read More

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http://dx.doi.org/10.1186/s12998-019-0232-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436233PMC