717 results match your criteria Middle Ear Tympanic Membrane Infections


BIGDATA: A Protocol to Create and Extend a 25-Year Clinical Trial and Observational Data Asset to Address Key Knowledge Gaps in Otitis Media and Hearing Loss in Australian Aboriginal and Non-Aboriginal Children.

Front Pediatr 2022 14;10:804373. Epub 2022 Apr 14.

Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.

Introduction: Otitis media (OM) is a common childhood illness, often resolving without intervention and acute and long-term complications are rare. However, Australian Aboriginal and Torres Strait Islander infants and children experience a high burden of OM and are at high risk of complications (tympanic membrane perforation and chronic infections). Bacterial OM is commonly associated with , non-typeable , and . Read More

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Comp Med 2022 04 28;72(2):104-112. Epub 2022 Mar 28.

Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.

Otitis externa (OE) is a condition that involves inflammation of the external ear canal. OE is a commonly reported condition in humans and some veterinary species (for example, dogs, cats), but has not been reported in the literature in macaques. Here, we present a case series of acute and chronic OE likely precipitated by abrasion of the ear canal with a tympanic membrane electrode in 7 adult male rhesus macaques (). Read More

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Minimally invasive trans-tympanic eustachian tube occlusion animal model.

Int J Pediatr Otorhinolaryngol 2022 May 23;156:111070. Epub 2022 Feb 23.

Department of Otolaryngology, Head and Neck Surgery, Stanford University, Stanford, USA. Electronic address:

Objective: Eustachian tube dysfunction is believed to be involved in the pathogenesis of many middle ear diseases including chronic suppurative otitis media. We aimed to describe a simple and reliable animal model of Eustachian Tube obstruction to further research into middle ear disorders.

Study Design: Prospective cohort study in animals. Read More

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Clinical Practice Guideline: Tympanostomy Tubes in Children (Update).

Otolaryngol Head Neck Surg 2022 02;166(1_suppl):S1-S55

American Academy of Otolaryngology-Head and Neck Surgery Foundation, Alexandria, Virginia, USA.

Objective: Insertion of tympanostomy tubes is the most common ambulatory surgery performed on children in the United States. Tympanostomy tubes are most often inserted because of persistent middle ear fluid, frequent ear infections, or ear infections that persist after antibiotic therapy. All these conditions are encompassed by the term (middle ear inflammation). Read More

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February 2022

Delivery of remote otology care: a UK pilot feasibility study.

BMJ Open Qual 2022 02;11(1)

ENT Department, Royal National Throat Nose and Ear Hospital, London, UK

Introduction: The COVID-19 pandemic has catalysed the need to implement the National Health Service Long-Term Plan to deliver more care in the community and to reduce face-to-face hospital appointments by up to 33%. This study aimed to assess the feasibility of a remote otology service from triage through to delivery.

Methods: New adult otology referrals at a tertiary ear, nose and throat (ENT) hospital aged between 18 and 70 with hearing loss or tinnitus were included. Read More

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February 2022

Ear microbiota and middle ear disease: a longitudinal pilot study of Aboriginal children in a remote south Australian setting.

BMC Microbiol 2022 01 13;22(1):24. Epub 2022 Jan 13.

Microbiome and Host Health, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

Background: Otitis media (OM) is a major disease burden in Australian Aboriginal children, contributing to serious long-term health outcomes. We report a pilot analysis of OM in children attending an outreach ear and hearing clinic in a remote south Australian community over a two-year period. Our study focuses on longitudinal relationships between ear canal microbiota characteristics with nasopharyngeal microbiota, and clinical and treatment variables. Read More

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January 2022

Permeation of polyethylene glycols across the tympanic membrane.

Giant (Oxf) 2021 Jun 8;6. Epub 2021 Apr 8.

Laboratory for Biomaterials and Drug Delivery, The Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.

Localized and non-invasive delivery of therapeutics across barriers in the body is challenging. Examples include the flux of drugs across the tympanic membrane (TM) for the treatment of middle ear infections, and across the round window to treat inner ear disease. With the emergence of macromolecular therapies, the question arises as to whether such delivery can be achieved with macromolecules. Read More

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Innate Immunity in the Middle Ear Mucosa.

Front Cell Infect Microbiol 2021 29;11:764772. Epub 2021 Oct 29.

Menzies Health Institute Queensland, School of Medicine, Griffith University, Gold Coast, QLD, Australia.

Otitis media (OM) encompasses a spectrum of clinical presentations ranging from the readily identifiable Acute OM (AOM), which is characterised by otalgia and fever, to chronic otitis media with effusion (COME) where impaired hearing due to middle ear effusion may be the only clinical symptom. Chronic suppurative OM (CSOM) presents as a more severe form of OM, involving perforation of the tympanic membrane. The pathogenesis of OM in these varied clinical presentations is unclear but activation of the innate inflammatory responses to viral and/or bacterial infection of the upper respiratory tract performs an integral role. Read More

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November 2021

Severe acute otitis media and mastoiditis caused by group A beta-hemolytic streptococcus.

Laryngoscope Investig Otolaryngol 2021 Oct 16;6(5):1158-1166. Epub 2021 Sep 16.

Department of Otorhinolaryngology-Head and Neck Surgery, Head and Neck Center Helsinki University Hospital and University of Helsinki Helsinki Finland.

Objective: To describe the characteristics, diagnostics, treatment, and outcome of severe acute otitis media (AOM) and acute mastoiditis (AM) caused by group A beta-hemolytic streptococcus (GAS).

Study Design: A retrospective cohort study.

Methods: The yearly incidence of inpatient care-needing GAS AOM/AM patients in our hospital catchment area between 2002 and 2018 was investigated. Read More

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October 2021

Endoscopic sinus surgery improves Eustachian tube function in patients with chronic rhinosinusitis: a multicenter prospective study.

Rhinology 2021 Dec;59(6):560-566

Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China 2 Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, Guangdong, China.

Background: Patients with chronic rhinosinusitis (CRS) often have Eustachian tube dysfunction (ETD) symptoms. This study aimed to prospectively investigate the effect of endoscopic sinus surgery (ESS) on improvement of Eustachian tube function in CRS patients with ETD from a Chinese population and determine factors associated with improvement.

Methods: A prospective study was performed in CRS patients with ETD who underwent ESS from 3 tertiary medical centers in south China. Read More

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December 2021

A change in clinical practice for aural foreign bodies - what we learnt from the coronavirus disease 2019 pandemic.

J Laryngol Otol 2021 Sep 5;135(9):825-828. Epub 2021 Aug 5.

ENT Department, Milton Keynes University Hospital, Milton Keynes, UK.

Objective: This case series, conducted during the coronavirus disease 2019 pandemic, investigates the impact of leaving aural foreign bodies in situ for a prolonged period of time, including the risk of complications and success rates of subsequent removal attempts.

Method: A retrospective study of aural foreign body referrals over a six-month period was carried out.

Results: Thirty-four patients with 35 foreign bodies were identified (6 organic and 29 inorganic). Read More

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September 2021

Optical absorbance of the tympanic membrane in rat and human samples.

PLoS One 2021 22;16(7):e0254902. Epub 2021 Jul 22.

Department of Otorhinolaryngology, Hannover Medical School, Hannover, Germany.

Chronic infections are often connected to biofilm formation. In presence of implants, this can lead to loss of the implant. Systemic or local application of drugs is relatively ineffective in case of biofilm formation. Read More

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November 2021

Tuberculous otitis media in Vietnam: Clinical features and diagnostic difficulties.

Eur Ann Otorhinolaryngol Head Neck Dis 2021 Dec 7;138(6):467-469. Epub 2021 Jul 7.

Department of Otorhinolaryngology, School of Medicine and Pharmacy, Vietnam National University, 144 Xuan Thuy Street, Hanoi City, Viet Nam.

Objectives: The purpose of this article is to draw the attention of otorhinolaryngologists to tuberculous otitis media in the light of two cases illustrating the diagnostic difficulties of this rare form of extrapulmonary tuberculosis, which often presents as subacute otomastoiditis or apparently benign chronic otitis media. It is characterized by symptoms such as atonic tympanic membrane perforation with granulation tissue, absence of any history of otitis media, facial paralysis or severe otosclerosis, and failure to respond to the usual treatments.

Case Reports: The first case was a 24-year-old man referred for right chronic otitis media present for 18 months despite topical treatment and tympanoplasty. Read More

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December 2021

Correlation Between Video-Otoendoscopy and Tympanograms of Patients with Acute Middle Ear Infections.

Indian J Otolaryngol Head Neck Surg 2021 Jun 30:1-8. Epub 2021 Jun 30.

Department of ENT and HNS, SRN Hospital, Prayagraj, Uttar Pradesh India.

The tympanic membrane (TM) undergoes a number of pathological changes in middle ear disease which can be detected by a video-otoendoscope. Middle ear disease is also accompanied by changes in middle ear pressure which can be assessed by tympanometry. The objectives of this study were to find the correlation between video-otoendoscopy and tympanometry in acute middle ear infections and to deduce which of the two is more efficient and reliable for early diagnosis. Read More

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TOTAL EAR CANAL ABLATION AND LATERAL BULLA OSTEOTOMY (TECA-LBO) IN ATLANTIC HARBOR SEALS () FOR SUCCESSFUL SURGICAL MANAGEMENT OF OTITIS MEDIA.

J Zoo Wildl Med 2021 Jun;52(2):827-837

National Marine Life Center, MA 02532, USA.

Chronic, severe otitis media was diagnosed in four Atlantic harbor seals (), three of which were stranded animals undergoing rehabilitation. All seals presented with unilateral purulent aural discharge that would intermittently recur despite prolonged topical and systemic antimicrobial therapy. Aerobic culture from aural discharge isolated multidrug-resistant organisms in all seals, including , , , and/or . Read More

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Handheld Briefcase Optical Coherence Tomography with Real-Time Machine Learning Classifier for Middle Ear Infections.

Biosensors (Basel) 2021 May 3;11(5). Epub 2021 May 3.

Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

A middle ear infection is a prevalent inflammatory disease most common in the pediatric population, and its financial burden remains substantial. Current diagnostic methods are highly subjective, relying on visual cues gathered by an otoscope. To address this shortcoming, optical coherence tomography (OCT) has been integrated into a handheld imaging probe. Read More

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Comparison of Tympanic Membrane Perforation With and Without Calcification of Anterior Mallear Ligament Under Transcanal Endoscopic Type I Tympanoplasty.

Ear Nose Throat J 2021 Jul 16;100(6):411-416. Epub 2021 May 16.

Department of Otorhinolaryngology-Head and Neck Surgery, 89657The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.

Objectives: Chronic suppurative otitis media (CSOM) induced tympanic membrane perforation (TMP) can be accompanied by anterior mallear ligament (AML) calcification. So far, comparative evaluations of TMP with and without AML calcification have rarely been reported. The aim of the current study is to compare the hearing outcomes of TMP with and without calcification of AML under transcanal endoscopic type I tympanoplasty. Read More

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Prevalence and characteristics of children with otitis media with effusion in Vietnam.

Vaccine 2021 05 13;39(19):2613-2619. Epub 2021 Apr 13.

Department of Otolaryngology, Nagasaki University Hospital, Nagasaki, Japan.

Purpose: Otitis media with effusion (OME) commonly occurs and persists in young children. It can cause hearing impairment and damage to the tympanic membrane without treatment. We aimed to determine the prevalence and association of Streptococcus pneumoniae in the nasopharynx of healthy children before the introduction of a pneumococcal conjugate vaccine. Read More

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Chronic otorrhoea, otalgia and hearing loss not responding to antibiotics and tympanoplasty surgery.

BMJ Case Rep 2021 Apr 2;14(4). Epub 2021 Apr 2.

Department of Otolaryngology, Kantonsspital Aarau AG, Aarau, Switzerland.

Chronic otorrhoea from a tympanic membrane perforation is common. We present the case of a patient who had already received seemingly adequate treatment for his condition in the past. Yet, he presented to our outpatient clinic with worsening otalgia and otorrhoea, progressive hearing loss and a new tympanic membrane perforation. Read More

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Comparison of graft uptake by underlay and overlay technique in myringoplasty.

J Ayub Med Coll Abbottabad 2020 Oct-Dec;32(Suppl 1)(4):S640-S643

PIMS Islamabad, Pakistan.

Background: About 80% of tympanic membrane tears consequential of middle ear infections or trauma restore spontaneously. Myringoplasty is the procedure to fix the perforation which fails to heal. It is of two types; overlay and underlay techniques. Read More

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[Transcanal endoscopic middle ear surgery in children with chronic suppurative otitis media].

Vestn Otorinolaringol 2021 ;86(1):25-29

N.I. Pirogov Russian National Research Medical University, Moscow, Russia.

Otomicroscopic surgery remains the gold standard in the surgical treatment of patients with CHS. Endoscopic ear surgery is gaining more and more importance as an adjunct to microsurgery. Recently, thanks to the resolution of the endoscopic technique, endoscopic surgery can be used as an independent method. Read More

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Evaluation of Vibrant Soundbridge™ positioning and results with laser doppler vibrometry and the finite element model.

Exp Ther Med 2021 Mar 25;21(3):262. Epub 2021 Jan 25.

Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.

The etiology of hearing loss originates from genetic factors and includes several other events including infections, working or living environment, as well as several endocrine and metabolic disorders. The Vibrant Soundbridge (VSB) is an implantable hearing aid whose floating mass transducer (FMT) is attached to the long process of the incus. The device is used for pure sensorineural hearing loss with an intact middle ear. Read More

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Topical versus systemic antibiotics for chronic suppurative otitis media.

Cochrane Database Syst Rev 2021 02 9;2:CD013053. Epub 2021 Feb 9.

Telethon Kids Institute, The University of Western Australia, Perth, Australia.

Background: Chronic suppurative otitis media (CSOM), sometimes referred to as chronic otitis media (COM), is a chronic inflammation and often polymicrobial infection (involving more than one micro-organism) of the middle ear and mastoid cavity, characterised by ear discharge (otorrhoea) through a perforated tympanic membrane. The predominant symptoms of CSOM are ear discharge and hearing loss. Antibiotics are the most common treatment for CSOM, which act to kill or inhibit the growth of micro-organisms that may be responsible for the infection. Read More

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February 2021

Mastoid effusion on temporal bone MRI in patients with Bell's palsy and Ramsay Hunt syndrome.

Sci Rep 2021 02 4;11(1):3127. Epub 2021 Feb 4.

Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University Medical Center, Research Institute of Medical Science, Konkuk University School of Medicine, 120-1 Neungdong-ro, Gwangjin-gu, Seoul, 05030, Republic of Korea.

This study aimed to investigate the incidence of mastoid effusion on temporal bone magnetic resonance imaging (MRI) in patients with Bell's palsy (BP) and Ramsay Hunt syndrome (RHS), and evaluate the usefulness of mastoid effusion in early differential diagnosis between BP and RHS. The incidence of mastoid effusion on 3.0 T-temporal bone MRI, which was conducted within 10 days after the onset of acute facial nerve palsy, was compared between 131 patients with BP and 33 patients with RHS. Read More

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February 2021

Evaluation and comparison of tympanoplasty efficacy with tympanic membrane perforation after chronic suppurative otitis media in dry ear with different microorganisms.

Am J Otolaryngol 2021 May-Jun;42(3):102900. Epub 2021 Jan 9.

Department of Otorhinolaryngology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:

Objective: To investigate the distribution of pathogenic bacteria in patients with tympanic membrane perforation after chronic suppurative otitis media (CSOM) in dry ear and its influence on the success rate of tympanoplasty and postoperative infection.

Methods: 740 patients with tympanic membrane perforation after CSOM underwent endoscopic tympanoplasty were selected. The mucosal surface secretion of middle-ear was collected for bacterial culture and drug sensitivity test. Read More

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October 2021

In vivo dynamic characterization of the human tympanic membrane using pneumatic optical coherence tomography.

J Biophotonics 2021 04 18;14(4):e202000215. Epub 2020 Aug 18.

Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

Decreased mobility of the human eardrum, the tympanic membrane (TM), is an essential indicator of a prevalent middle ear infection. The current diagnostic method to assess TM mobility is via pneumatic otoscopy, which provides subjective and qualitative information of subtle motion. In this study, a handheld spectral-domain pneumatic optical coherence tomography system was developed to simultaneously measure the displacement of the TM, air pressure inputs applied to a sealed ear canal, and to perform digital pneumatic otoscopy. Read More

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Otitis media in coronavirus disease 2019: a case series.

J Laryngol Otol 2021 Jan 7;135(1):10-13. Epub 2021 Jan 7.

Department of Otolaryngology, Masih Daneshvari Hospital, Tehran, Iran.

Background: Manifestations of the coronavirus disease 2019 in ENT include sore throat, rhinorrhoea, anosmia and dysgeusia. Whether coronavirus disease 2019 causes otitis media is not known.

Objective: To assess the presence of otitis media in a series of patients with confirmed coronavirus disease 2019 and ENT symptoms. Read More

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January 2021

Molecular Screening Strategy to Identify a Non-invasive Delivery Mechanism for the Treatment of Middle Ear Disorders.

Front Med (Lausanne) 2020 18;7:503819. Epub 2020 Dec 18.

Department of Surgery/Otolaryngology, UCSD School of Medicine, San Diego, CA, United States.

Middle ear ailments include a broad range of pathological conditions. Otitis media is the leading middle ear disease of childhood, which incurs significant health care resources in developed countries and, in developing countries, causes significant mortality and morbidity. Recurrent and chronic infections of the middle ear lead to the prolonged presence of inflammatory factors and cellular infiltrates resulting in temporary hearing loss. Read More

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December 2020

Image-guided surgical navigation for bone-conduction hearing device implant placement.

Int J Pediatr Otorhinolaryngol 2020 Dec 29;139:110392. Epub 2020 Sep 29.

Baylor College of Medicine, Department of Otolaryngology - Head and Neck Surgery, One Baylor Plaza Suite NA-102, Houston, TX, 77030, USA; Texas Children's Hospital, Division of Pediatric Otolaryngology, 6701 Fannin St, Suite 640, Houston, TX, 77030, USA. Electronic address:

Introduction: For pediatric patients, bone-conduction hearing devices (BCHD) have demonstrated excellent outcomes. Unique to this population, BCHD implant surgeries can be technically challenging in children due to thinner, developing bone and syndromes with atypical anatomy. Image-guided surgical navigation (IGSN) clarifies underlying skull structure, potentially improving outcomes. Read More

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December 2020

Effectiveness of myringoplasty in patients with eosinophilic otitis media.

Auris Nasus Larynx 2021 Jun 29;48(3):368-376. Epub 2020 Sep 29.

Jichi Ika University Saitama Medical Center, Department of Otolaryngology, 1-847 Amanuma, Saitama 330-8503, Japan.

Objective: To determine whether myringoplasty can be an effective tool to control eosinophilic otitis media and improve hearing.

Methods: Severity scores for patients with eosinophilic otitis media with or without myringoplasty were retrospectively analyzed. Surgical outcomes were assessed and compared to those of patients with control: chronic otitis media with tympanic membrane perforation. Read More

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