4,237,036 results match your criteria Middle Ear Tympanic Membrane Infections


Predictive factors associated with driving under the influence among Brazilian drug-using drivers.

Accid Anal Prev 2018 Dec 12;123:256-262. Epub 2018 Dec 12.

Center for Drug and Alcohol Research, Hospital de Clínicas de Porto Alegre, Rua Professor Álvaro Alvim, 400, 90420-020, Porto Alegre, RS, Brazil.

The incidence of driving under the influence of psychoactive substances (DUI) and its recidivism can be curtailed by the proper identification of specific and predictive characteristics among drug users. In this sense, interpersonal violence (IV), psychiatric comorbidity and impulsivity seem to play an important role in DUI engagement according to previous studies. There are, however, limited data originated from low and middle income countries. Read More

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December 2018

Protective effect of low-intensity transcranial ultrasound stimulation after differing delay following an acute ischemic stroke.

Brain Res Bull 2018 Dec 12. Epub 2018 Dec 12.

Scientific Clinical Specialist, Siemens Ltd., Beijing, China.

Background: Ischemic stroke is a clinically common disease requiring early treatment in the acute period of stroke onset. Such early treatment reduces the level of brain injury, promotes functional recovery, and improves long-term prognosis. Previous studies have demonstrated that, in the event of an acute ischemic stroke, low-intensity transcranial ultrasound stimulation (LITUS) can provide neuroprotection. Read More

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December 2018

Middle- and long-term outcomes of hybrid technique of complicated Stanford type-B aortic dissection.

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiovascular Surgery, the second Hospital of Jilin University, Changchun, Jilin, China, 130041. Electronic address:

Background: To evaluate the middle- and long- clinical outcomes of aortic implantation of stent-grafts under direct vision (hybrid surgical treatment).

Methods: From March 2009 to December 2014, 285 patients presented with type-B aortic dissection. Of these, 35 complicated patients underwent hybrid surgical treatment. Read More

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December 2018

Treadmill exercise ameliorates focal cerebral ischemia/reperfusion-induced neurological deficit by promoting dendritic modification and synaptic plasticity via upregulating caveolin-1/VEGF signaling pathways.

Exp Neurol 2018 Dec 12. Epub 2018 Dec 12.

Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou 325027, Zhejiang, China. Electronic address:

Dendritic and synaptic plasticity in the penumbra are important processes and are considered to be therapeutic targets of ischemic stroke. Treadmill exercise is known to be a beneficial treatment following stroke. However, its effects and potential mechanism in promoting dendritic and synaptic plasticity remain unknown. Read More

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December 2018

MicroRNA-212 promotes the recovery function and vascular regeneration of endothelial progenitor cells in mice with ischemic stroke through inactivation of the notch signaling pathway via downregulating MMP9 expression.

J Cell Physiol 2018 Dec 15. Epub 2018 Dec 15.

Department of Neurology, Cangzhou Central Hospital, Cangzhou, China.

Ischemic stroke is a refractory disease caused by cerebral ischemic injury, which results in brain dysfunction. This study intends to investigate the effects of microRNA-212 (miR-212) on the recovery function and vascular regeneration of endothelial progenitor cells (EPCs) by inactivation of the Notch signaling pathway by binding to matrix metallopeptidase 9 (MMP9) in mice with ischemic stroke. According to the results of database retrieval systems and data analysis, MMP9 was predicted as a gene related to ischemic stroke and miR-212 is a potential regulating mRNA of MMP9. Read More

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December 2018

Depressive symptoms and cerebral microvascular disease in adults with Type 1 diabetes mellitus.

Diabet Med 2018 Dec 15. Epub 2018 Dec 15.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

Aim: To assess the prevalence of and risk factors for depressive symptoms, comparing a sample of middle-aged adults with and without juvenile-onset Type 1 diabetes mellitus, and to determine if depressive symptoms were associated with white matter hyperintensity volume among those with Type 1 diabetes.

Methods: Depressive symptoms and white matter hyperintensities were compared between adults (age range 30-65 years) with juvenile-onset Type 1 diabetes (n=130) and adults without Type 1 diabetes (n=133). The association of Type 1 diabetes with depression was computed before and after adjustment for white matter hyperintensities. Read More

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December 2018

Cell-Based Model of the Generation and Maintenance of the Shape and Structure of the Multilayered Shoot Apical Meristem of Arabidopsis thaliana.

Bull Math Biol 2018 Dec 14. Epub 2018 Dec 14.

Department of Mathematics, University of California, Riverside, USA.

One of the central problems in animal and plant developmental biology is deciphering how chemical and mechanical signals interact within a tissue to produce organs of defined size, shape, and function. Cell walls in plants impose a unique constraint on cell expansion since cells are under turgor pressure and do not move relative to one another. Cell wall extensibility and constantly changing distribution of stress on the wall are mechanical properties that vary between individual cells and contribute to rates of expansion and orientation of cell division. Read More

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December 2018

Identification of the gene encoding the TATA box-binding protein-associated factor 1 (TAF1) and its putative role in the heat shock response in the protozoan parasite Entamoeba histolytica.

Parasitol Res 2018 Dec 15. Epub 2018 Dec 15.

Departamento de Biología Celular, Cinvestav-IPN, Av. IPN 2508, Col. San Pedro Zacatenco, 07360, Ciudad de México, Mexico.

Transcription factor IID (TFIID) is a cornerstone in the transcription initiation in eukaryotes. It is composed of TBP and approximately 14 different subunits named TBP-associated factors (TAFs). TFIID has a key role in transcription of many genes involved in cell proliferation, cell growth, cell cycle, cell cycle checkpoint, and various other processes as well. Read More

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December 2018
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Effect of a combined programme of dietary restriction and physical activity on the physical function and body composition of obese middle-aged and older adults with knee OA (DRPA): protocol for a feasibility study.

BMJ Open 2018 Dec 14;8(12):e021051. Epub 2018 Dec 14.

School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.

Introduction: Knee osteoarthritis (OA) is the most common chronic illness among older adults. Up to the submission date of this protocol, there are no published UK studies reporting the efficacy of a combined intervention programme of physical activity and dietary restriction on the musculoskeletal function of obese older adults with knee OA in spite of the clinical recommendation for exercise and diet for people with knee OA. The aim of this study is to assess the feasibility and acceptability of a combined dietary restriction and physical activity intervention programme and collect preliminary data. Read More

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December 2018

Stent-screw-assisted internal fixation: the SAIF technique to augment severe osteoporotic and neoplastic vertebral body fractures.

J Neurointerv Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Neuroradiology, Papa Giovanni XXIII Hospital, Bergamo, Italy.

Objectives: To describe a new technique to obtain minimally invasive but efficient vertebral body (VB) reconstruction, augmentation, and stabilization in severe osteoporotic and neoplastic fractures, combining two pre-existing procedures. The implant of vertebral body stents (VBS) is followed by insertion of percutaneous, fenestrated, cement-augmented pedicular screws that act as anchors to the posterior elements for the cement/stent complex. The screws reduce the risk of stent mobilization in a non-intact VB cortical shell and bridge middle column and pedicular fractures. Read More

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December 2018

Safety and efficacy of cangrelor in acute stenting for the treatment of cerebrovascular pathology: preliminary experience in a single-center pilot study.

J Neurointerv Surg 2018 Dec 14. Epub 2018 Dec 14.

Lyerly Neurosurgery, Baptist Neurological Institute, Baptist Health, Jacksonville, Florida, USA.

Background: Treatment of acute cerebrovascular pathology, such as acute ischemic stroke or intracranial aneurysms, presents a challenge if an extracranial or intracranial stent is required; immediate platelet inhibition is vital. To date, there is no standardized approach for antiplatelet inhibition in an acute setting.

Objective: To report our preliminary experience and lessons learnt using cangrelor in acute neurointervention. Read More

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December 2018

Electroacupuncture Regulates Hippocampal Synaptic Plasticity via Inhibiting Janus-Activated Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling in Cerebral Ischemic Rats.

J Stroke Cerebrovasc Dis 2018 Dec 11. Epub 2018 Dec 11.

College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, PR China; Rehabilitation Medical Technology Joint National Local Engineering Research Center, Fuzhou, Fujian, PR China.

Objective: To determine the mechanism(s) involved in electroacupuncture (EA)-mediated improvements in synaptic plasticity in a rat model of middle cerebral artery occlusion and reperfusion (MCAO/R)-induced cognitive deficits.

Methods: Focal cerebral ischemic stroke was induced by (MCAO/R) surgery. Rats were randomly split into 4 groups: control group (sham operation control), MCAO group, Baihui (GV 20) and Shenting (GV 24) acupoint EA group (verum acupuncture, MCAO + VA), and nonacupoint EA group (control acupuncture, MCAO + CA). Read More

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December 2018

Funding and services needed to achieve universal health coverage: applications of global, regional, and national estimates of utilisation of outpatient visits and inpatient admissions from 1990 to 2016, and unit costs from 1995 to 2016.

Lancet Public Health 2018 Dec 11. Epub 2018 Dec 11.

Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA. Electronic address:

Background: To inform plans to achieve universal health coverage (UHC), we estimated utilisation and unit cost of outpatient visits and inpatient admissions, did a decomposition analysis of utilisation, and estimated additional services and funds needed to meet a UHC standard for utilisation.

Methods: We collated 1175 country-years of outpatient data on utilisation from 130 countries and 2068 country-years of inpatient data from 128 countries. We did meta-regression analyses of annual visits and admissions per capita by sex, age, location, and year with DisMod-MR, a Bayesian meta-regression tool. Read More

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December 2018

Prevalence of Known Risk Factors for Type 2 Diabetes Mellitus in Multiethnic Urban Youth in Edmonton: Findings From the WHY ACT NOW Project.

Can J Diabetes 2018 Oct 9. Epub 2018 Oct 9.

Indigenous and Global Health Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Objectives: The Canadian Diabetes Risk Assessment Questionnaire (CANRISK) is a validated, evidence-based, self-administered tool to assess the risk for type 2 diabetes mellitus in multiethnic Canadian adults. Identifying individuals at high risk for type 2 diabetes allows early intervention that improves modifiable risk factors. This study examined the risk factors for type 2 diabetes in multiethnic urban youth in Edmonton, Alberta. Read More

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October 2018

Transcriptomic analyses uncover emerging roles of mucins, lysosome/secretory addressing and detoxification pathways in insect midguts.

Curr Opin Insect Sci 2018 Oct 5;29:34-40. Epub 2018 Jun 5.

Laboratório de Química e Função de Proteínas e Peptídeos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Brazil.

The study of insect midgut features has been made possible by the recent availability of transcriptome datasets. These data uncovered the preferential expression of mucus-forming mucins at midgut regions that require protection (e.g. Read More

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October 2018

Academic monitoring and support of undergraduate nursing education programme: A middle-range theory.

Curationis 2018 Dec 3;41(1):e1-e11. Epub 2018 Dec 3.

School of Nursing and Public Health, University of KwaZulu-Natal.

Background:  Globally, there is consensus on the need for student support to address high student attrition and low throughputs, especially in nursing and midwifery programmes.

Objectives:  This study analysed the implementation of academic monitoring and support (AMS) in an undergraduate nursing programme to generate a context-informed academic monitoring and support middle-range theory.

Method:  An ethnographic design and grounded theory approach were adopted in this study. Read More

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December 2018
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The More Educated, the Healthier: Evidence from Rural China.

Int J Environ Res Public Health 2018 Dec 13;15(12). Epub 2018 Dec 13.

Center for Chinese Agricultural Policy, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China.

Education, as an important aspect of human capital, not only affects the economic returns of an individual, but also affects non-economic returns. This paper uses data from the China Family Panel Studies (CFPS) in 2014 and explores the impact of education on the health status of rural residents by using the family fixed-effect model. We find that education can improve the self-reported health status and reduce the possibility of depression of rural residents. Read More

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December 2018
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Enhancing GaN LED Efficiency through Nano-Gratings and Standing Wave Analysis.

Nanomaterials (Basel) 2018 Dec 13;8(12). Epub 2018 Dec 13.

Electrical Engineering Department, California Polytechnic State University, San Luis Obispo, CA 93407, USA.

Based on our recent work, this paper reviews our theoretical study on gallium nitride (GaN) light-emitting-diode (LED). The focus of the paper is to improve LED light extraction efficiency through various nano-grating designs. The gratings can be designed at different locations, such as at the top, the middle, and the bottom, on the LED. Read More

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December 2018

A Simple Graphene NH₃ Gas Sensor via Laser Direct Writing.

Sensors (Basel) 2018 Dec 13;18(12). Epub 2018 Dec 13.

Department of Mechanical and Electrical Engineering, Xiamen University, Xiamen 361005, China.

Ammonia gas sensors are very essential in many industries and everyday life. However, their complicated fabrication process, severe environmental fabrication requirements and desorption of residual ammonia molecules result in high cost and hinder their market acceptance. Here, laser direct writing is used to fabricate three parallel porous 3D graphene lines on a polyimide (PI) tape to simply construct an ammonia gas sensor. Read More

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December 2018

Puerarin attenuates neurological deficits via Bcl-2/Bax/cleaved caspase-3 and Sirt3/SOD2 apoptotic pathways in subarachnoid hemorrhage mice.

Biomed Pharmacother 2019 Jan 5;109:726-733. Epub 2018 Nov 5.

Department of Neurosurgery, Huashan Hospital Affiliated to Fudan University, 12 Wulongmuqi Middle Road, Shanghai, 200040, PR China. Electronic address:

Background: Subarachnoid hemorrhage (SAH) results in many brain dysfunctions and the neuroprotective function of puerarin after brain damage has been demonstrated in several studies. But whether puerarin can reduce brain nerve damage after SAH is not clear.In this study, we hypothesized that puerarin had the neuroprotective effect after SAH, and this protection could be mediated by bothBcl-2/Bax/Cleaved caspase-3 and SIRT3/SOD2 apoptotic signaling pathways. Read More

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January 2019

Neuroprotection of quercetin on central neurons against chronic high glucose through enhancement of Nrf2/ARE/glyoxalase-1 pathway mediated by phosphorylation regulation.

Biomed Pharmacother 2019 Jan 27;109:2145-2154. Epub 2018 Nov 27.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China.

Although dietary flavonoid quercetin alleviates diabetes-associated cognitive decline in rodents, the mechanisms are not clearly clarified. This study was designed to investigate whether quercetin showed neuroprotection on central neurons against chronic high glucose through the enhancement of Nrf2/ARE/glyoxalase 1 (Glo-1) pathway. SH-SY5Y cells were divided into 8 groups: normal glucose, high glucose (HG), osmotic pressure control, solvent control, HG plus low, middle, high concentrations of quercetin, or Nrf2 activator (sulforaphane). Read More

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January 2019

Apigetrin treatment attenuates LPS-induced acute otitis media though suppressing inflammation and oxidative stress.

Biomed Pharmacother 2019 Jan 26;109:1978-1987. Epub 2018 Nov 26.

Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.

The natural course of otitis media in children is acute and self-limiting. Nevertheless, about 10-20% children could experience recurrent or persistent otitis media. Thus, finding effective candidate to prevent acute otitis media is urgently required. Read More

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January 2019

Neferine inhibits growth and migration of gastrointestinal stromal tumor cell line GIST-T1 by up-regulation of miR-449a.

Biomed Pharmacother 2019 Jan 26;109:1951-1959. Epub 2018 Nov 26.

Department of Gastroenterology, Linyi Central Hospital, Linyi, 276400, China. Electronic address:

Background: Gastrointestinal stromal tumor (GIST) threatens the health of middle-aged and older people with high recurrence rate and low survival rate. In this study, Neferin (Nef) was hoped to control growth and migration of GIST cell line GIST-T1.

Methods: Cell viability, proliferation, apoptosis, and migration were determined by cell counting kit-8 (CCK-8) assay, bromodeoxyuridine (BrdU) assay, Annexin V-FITC/PI double staining method, and Transwell assay, respectively. Read More

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January 2019

TCF7L2 activated HOXA-AS2 decreased the glucocorticoid sensitivity in acute lymphoblastic leukemia through regulating HOXA3/EGFR/Ras/Raf/MEK/ERK pathway.

Biomed Pharmacother 2019 Jan 16;109:1640-1649. Epub 2018 Nov 16.

Department of Pediatric Internal Medicine, Cangzhou Central Hospital, Xihuan Middle Street, Yunhe District, Cangzhou city, Hebei Province 061000, China.

Acute lymphoblastic leukemia (ALL) is characterized by abnormal lymphoblasts accumulation in the bone marrow and blood. Despite great efforts have been made in exploring novel therapeutic method, the prognosis of children with ALL is still unsatisfied. Glucocorticoid (GC) resistance is a great obstacle for the clinical treatment of ALL. Read More

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January 2019

Comparative Analysis of the Exposure and Surgical Freedom of the Endoscopic Extended Minipterional Craniotomy and the Transorbital Endoscopic Approach to the Anterior and Middle Cranial Fossae.

Oper Neurosurg (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurosurgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: Numerous minimally invasive approaches to the skull base have been successively developed. Knowledge of the surgical nuances of a specific approach may facilitate approach selection. This study sought to compare the nuances of an extended version of the minipterional craniotomy (EMPT) with those of the transorbital endoscopic approach (TOEA) to the anterior and middle cranial fossae (ACF and MCF, respectively). Read More

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December 2018

Increased incidence rate of hypothyroidism after iodine fortification in Denmark. A 20 year prospective population-based study.

J Clin Endocrinol Metab 2018 Dec 14. Epub 2018 Dec 14.

Department of Endocrinology, Aalborg University Hospital, Denmark.

Objective: To monitor the impact of a cautious iodine fortification (IF) on the incidence of overt hypothyroidism in two sub-populations with different levels of preexisting iodine deficiency (ID).

Design: A 20 years (1997-2016) prospective population-based study identified all new cases of diagnosed overt biochemical hypothyroidism in two open cohorts: a Western cohort with moderate ID (n=309,434, January 1st, 1997) and an Eastern cohort with mild ID (n=224,535, January 1st, 1997). A diagnostic algorithm was applied to all thyroid function tests performed within the study areas and possible new cases were verified individually. Read More

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December 2018

Moving Beyond Role-Play: Evaluating the Use of Virtual Reality to Teach Emotion Regulation for the Prevention of Adolescent Risk Behavior Within a Randomized Pilot Trial.

J Pediatr Psychol 2018 Dec 14. Epub 2018 Dec 14.

Bradley/Hasbro Children's Research Center/Rhode Island Hospital and the Warren Alpert Medical School of Brown University.

Objective: The purpose of the current pilot study was to evaluate the acceptability and preliminary impact of using immersive virtual reality environments (IVREs) paired with a brief emotion regulation and risk reduction intervention (ER + IVRE) relative to this same intervention content paired with role-plays (ER + RP).

Methods: Eighty-five adolescents attending middle school (grades 6th-8th; ages 12-15 years) in an urban northeast city were recruited and randomized to ER + IVRE (n = 44) or ER + RP (n = 41) and had complete data. Data examining acceptability, feasibility, sexual knowledge and attitudes, and ER were collected at baseline and 3 months after intervention completion. Read More

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December 2018

Prevalence and correlates of anemia among adolescents in Nepal: Findings from a nationally representative cross-sectional survey.

PLoS One 2018 14;13(12):e0208878. Epub 2018 Dec 14.

Department of Paediatrics, the University of Melbourne, Melbourne, Australia.

Anemia is regarded as major public health problem among adolescents in Low and Middle-Income Countries (LMICs) but there is limited primary data in many countries, including Nepal. This study investigated the prevalence and correlates of anemia in a nationally representative sample of adolescents within the 2014 National Adolescent Nutrition Survey in Nepal. A total of 3780 adolescents aged 10 to 19 years were selected from a cross-sectional survey through multi-stage cluster sampling. Read More

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December 2018

Prolonging food shelf-life by dual actives release from multi-layered polymer particles.

Colloids Surf B Biointerfaces 2018 Dec 4;175:281-290. Epub 2018 Dec 4.

Department of Materials Science and Engineering, Indian Institute of Technology, Delhi, 110016, India. Electronic address:

Biodegradable polymer based 'controlled release packaging' technology has ability to release packaging actives in controlled manner to prolong the food shelf-life. Currently available systems are not sufficiently capable of releasing multiple actives in sustainable fashion. Hence, the purpose of this study was to develop dual actives (antioxidant and antibacterial) loaded multilayered microparticles in one step and to release them at rates suitable for long-term inhibition of bacterial growth as well as lipid oxidation in food. Read More

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December 2018
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Ultrasound simulation model incorporating incident and reflected wave propagations along a common carotid artery.

Comput Biol Med 2018 Nov 13;104:267-277. Epub 2018 Nov 13.

Department of Electronic Engineering, Information School, Yunnan University, Kunming, Yunnan, 650091, China.

An ultrasound simulation model incorporating incident and reflected wave propagations is proposed to provide a realistic data source for validation of transit time (TT)-based local pulse wave velocity (PWV) estimation algorithms. First, the incident wave (IW) and reflected wave (RW) at a certain position over a common carotid artery (CCA) are estimated. Then, the propagating pulse waves (PWs) along the CCA are modelled with the synthesizations of the estimated IWs and RWs, whose occurrences are delayed in opposite sequences according to a preset PWV. Read More

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November 2018

Permafrost landslides promote soil CO emission and hinder C accumulation.

Sci Total Environ 2018 Dec 4;657:351-364. Epub 2018 Dec 4.

GFZ German Research Centre for Geosciences, Section Geomicrobiology, Telegrafenberg C-425, 14473 Potsdam, Germany; Institute of Earth and Environmental Sciences, University of Potsdam, 14476 Potsdam, Germany.

Landslides are common in high-latitude forest ecosystems that have developed on permafrost. The most vulnerable areas in the permafrost territories of Siberia occur on the south-facing slopes of northern rivers, where they are observed on about 20% of the total area of river slopes. Landslide disturbances will likely increase with climate change especially due to increasing summer-autumn precipitation. Read More

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December 2018

Role of the androgen receptor gene CAG repeat polymorphism on the sequence of pubertal events and adiposity in girls with high dehydroepiandrosterone sulfate.

J Pediatr Adolesc Gynecol 2018 Dec 11. Epub 2018 Dec 11.

Institute of Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile. Electronic address:

Study Objective: The Androgen Receptor (AR) harbors a variable repeat of a variable number of glutamine residues [(CAG)n] which seems to affect inversely AR transcriptional activity. We assessed whether (CAG)n affect the sequence of the androgen-sensitive pubertal events and body composition in prepubertal girls.

Design: and participants: Nested case-control study within the Growth and Obesity Cohort Study of 1196 low-middle income children (≈50% girls) from Santiago, Chile. Read More

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December 2018
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Asymptomatic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: Extent and implications for infection control: A systematic review.

Travel Med Infect Dis 2018 Dec 11. Epub 2018 Dec 11.

Aix Marseille Univ, Institut de Recherche pour le Développement (IRD), Assistance Publique-Hôpitaux de Marseille (AP-HM), Service de Santé des Armées (SSA), Microbes Vecteurs Infections Tropicales et Méditerranéennes (VITROME), Institut Hospitalo-Universitaire-Méditerranée Infection (IHU-Méditerranée Infection), Marseille, France.

Background: The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) emerged in 2012 and attracted an international attention as the virus caused multiple healthcare associated outbreaks. There are reports of the role of asymptomatic individuals play in the transmission of MERS-CoV, however, the exact role is now known.

Method: The MEDLINE/PubMed and Scopus databases were searched for relevant papers published till August 2018 describing asymptomatic MERS-CoV infection. Read More

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December 2018

Polyamine analogue QMA attenuated ischemic injury in MCAO rats via ERK and Akt activated Nrf2/HO-1 signaling pathway.

Eur J Pharmacol 2018 Dec 11. Epub 2018 Dec 11.

Key Laboratory of Natural Medicine and Immune Engineering, Henan University, Kaifeng 475001, People's Republic of China. Electronic address:

Previous research showed N-(quinolin-2-ylmethy) butane-1, 4-diamine (QMA), a polyamine analogue, was efficacious in the prevention of oxidative injury in models of cerebral ischemia. The present study manifested that pretreatment with QMA attenuated ischemic damage accompanying up regulation of Nuclear factor erythroid 2‑related factor (Nrf2), Heme oxygenase‑1 (HO‑1), p-ERK and p-Akt in cerebral cortex tissues of middle cerebral artery occlusion (MCAO) rats and oxygen-glucose deprivation (OGD)-treated PC12 cells. Further more, treatment with LY294002 (specific PI3K inhibitor), PD98059 (specific ERK inhibitor), brusatol (specific Nrf2 inhibitor) and SnPP (specific HO-1 inhibitor) deprived almost all the effects of QMA in MCAO rats and OGD-treated PC12 cells. Read More

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December 2018

Vernal Keratoconjunctivitis.

Surv Ophthalmol 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Vernal keratoconjunctivitis, a chronic, bilateral, seasonal allergic inflammatory disease of the eye, is an important cause of visual debilitation and impairment of quality of life in children and young adults in certain parts of the world such as the Mediterranean areas, Central and West Africa, the Middle East, Japan, the Indian subcontinent, and South America. It usually has a self-limiting course; however, in a few cases the disease is recurrent and leads to long-term visual disabling complications like keratoconus and limbal stem cell deficiency. The main pathogenic mechanism is IgE mediated; however, there may be non-IgE and certain non-specific hypersensitivity mechanisms. Read More

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December 2018

Atypical Prenatal Ultrasound Presentation and Neuropathological Findings in a Neonate With Alpha Thalassemia Major: A Case Report.

Pediatr Dev Pathol 2018 Dec 14:1093526618817655. Epub 2018 Dec 14.

1 Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Canada.

Alpha thalassemia major is a hemoglobinopathy caused by the inactivation or deletion of all 4 α-globin alleles. We describe a case of α-thalassemia major with atypical ultrasound and neuropathological findings. The mother had her first prenatal visit at 27 4/7 gestational weeks. Read More

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December 2018

The human visual system estimates angle features in an internal reference frame: A computational and psychophysical study.

J Vis 2018 Dec;18(13):10

Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics, Ministry of Education, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.

Angle perception is an important middle-level visual process, combining line features to generate an integrated shape percept. Previous studies have proposed two theories of angle perception-a combination of lines and a holistic feature following Weber's law. However, both theories failed to explain the dual-peak fluctuations of the just-noticeable difference (JND) across angle sizes. Read More

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December 2018

Supportive interventions to improve retention on ART in people with HIV in low- and middle-income countries: A systematic review.

PLoS One 2018 14;13(12):e0208814. Epub 2018 Dec 14.

Institute for Global Health Sciences, University of California, San Francisco, San Francisco, California, United States of America.

Objectives: To determine whether supportive interventions can increase retention in care for patients on antiretroviral therapy (ART) in low- and middle-income countries (LMIC).

Design: Systematic review and meta-analysis.

Methods: We used Cochrane Collaboration methods. Read More

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December 2018
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Activation of Supraspinatus and Infraspinatus Partitions and Periscapular Musculature during Rehabilitative Elastic Resistance Exercises.

Am J Phys Med Rehabil 2018 Dec 13. Epub 2018 Dec 13.

Department of Kinesiology, University of Waterloo, Waterloo, Canada.

Objective: The purpose of this study was to quantify the activation of partitions within supraspinatus and infraspinatus and some periscapular muscles during four resistance exercises with elastic bands.

Design: 27 right handed healthy volunteers (22.5 ± 2. Read More

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December 2018

The same with age: Evidence for age-related similarities in interpersonal accuracy.

J Exp Psychol Gen 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology.

Interpersonal accuracy refers to the ability to make accurate perceptions about others' social and emotional qualities. Despite this broad definition, the measurement of interpersonal accuracy remains narrow, as most studies focus on the accurate perception of others' emotional states. Moreover, previous research has relied primarily upon traditional tasks consisting of posed, prototypic expressions and behaviors as stimuli. Read More

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December 2018

[Clinical treatment of congenital middle ear cholesteatoma in children].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1097-1101

Children's National Medical Center, Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing,100045, China.

To summarize the clinical characteristics and clinical treatment of congenital cholesteatoma (CC) of the middle ear in children, provide early diagnosis methods and explore standardized diagnosis and treatment plan.A retrospective chart review of 94 patients with a diagnosis of middle ear cholesteatoma, in Beijing Children's Hospital, between 2009 and 2015 was carried on. 14 patients with CC were identified using the criteria proposed by Levenson, and were divided into two groups according to the course of disease. Read More

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[Analysis of features of ocular tilt reaction for patients with vestibular neuritis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1091-1094

Department of Ophthalmology, Guangxi Zhuang Autonomous Region People's Hospital.

To analyze the clinical characteristics of ocular tilt reaction in vestibular neuritis patients and discuss its value to the diagnosis of vestibular neuritis.Thirty-five patients with vestibular neuritis confirmed between January 2016 and March 2018 underwent bedside vestibular function physical examination including nystagmus, head impulse test(HIT),head shaking nystagmus(HSN), ocular tilt reaction(OTR), Romberg sign, Fukuda stepping. All patients underwent head CT scan and brain MRI scan + DWI to exclude bleeding and infarction. Read More

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[Application of technique of HRCT and multipliate plane reconstruction in analysis of image features of superior semicircular canal dehiscence].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1082-1085;1090

Department of Radiology, Southern Medical University Nanfang Hospital.

Application of technique of high resolution CT (HRCT) and multipliate plane reconstruction, analyzed the image features of suspicious superior semicircular canal dehiscence (SSCD) to improve the understanding of the SSCD.From January 2016 to April 2017, a total of 230 adult patients who checked temporal bone HRCT were collected in this retrospective study, of which 160 cases (320 ears) of the non-SSCD, 73 cases were male (146 ears), 87 cases were female (174 ears), aged 18 to 70 years old; 70 cases (113 ears) were suspicious diagnosed with SSCD, 33 cases were male (55 ears), 37 cases were female (58 ears), and 18 to 71 years old. The thin section CT scan of the temporal bone translocation was performed on all subjects, then the CT post processing workstation was used for multipliate plane reconstruction (MPR), and the main rows of coronal and oblique sagittal image reconstruction was performed. Read More

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[The application of cartilage in middle ear surgery].

Authors:
Y X Zhao L S Yu

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1912-1916

The aim of this study is to review the application, techniques and procedures of cartilage in the middle ear surgery. Cartilage offers the advantage of higher mechanical stability in tympanoplasty, which is the most common procedure in the middle ear surgery, thus apply to much complicated situation especially for tubal dysfunction and adhesive processes. There are many variations on the shape, size, thickness and technical matters of the cartilage grafts. Read More

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December 2018

[An endoscopic-assisted technique for the enlarged middle cranial fossa approach to the petroclival region: an anatomic study].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1882-1885

Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China.

Through the observation and measurement of the adjacent anatomical structures exposed by the pure microscope and endoscopic-assisted technique for the enlarged middle cranial fossa approach to the petroclival region, quantitative compare the advantages of endoscopic-assisted technique and the pure microscope exposure. The enlarged middle cranial fossa approach was performed on 10 cases (20 sides) fresh adult cadaveric head specimens in which the vessels were injected with colored silicone. At the end of every enlarged middle cranial fossa approachs, endoscope assisted technique was applied. Read More

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December 2018

Patients' narratives of their patient participation in the myocardial infarction pathway.

J Adv Nurs 2018 Dec 14. Epub 2018 Dec 14.

Clinic of medicine and rehabilitation, Møre og Romsdal Hospital Trust, Ålesund, Norway.

Aim: To explore how patients in areas without local percutaneous coronary intervention facilities experience patient participation in different phases of the myocardial infarction pathway.

Background: Acute treatment of myocardial infarction often involves percutaneous coronary intervention. In Norway, this treatment is centralized at certain hospitals; thus, patients often require long-distance transportation and experience frequent hospital transfers. Read More

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December 2018

Repeatability and reliability of quantitative fundus autofluorescence imaging in patients with early and intermediate age-related macular degeneration.

Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology and Optometry, Vienna Trial Center (VTC), Medical University of Vienna, Vienna, Austria.

Purpose: Quantification of fundus autofluorescence has only recently become available. We report our findings on the evaluation of the repeatability and reliability of quantitative fundus autofluorescence (qAF) measurements in patients with early and intermediate age-related macular degeneration (AMD), using the first approved and commercially available instrument.

Methods: A total of 43 eyes of 22 patients (aged between 52 and 84 years) diagnosed with early and intermediate AMD were included. Read More

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December 2018

Longitudinal change in the cerebroplacental ratio and the risk of stillbirth.

Ultrasound Obstet Gynecol 2018 Dec 13. Epub 2018 Dec 13.

Fetal Medicine Unit, St George's Hospital, St George's University of London, UK Cranmer Terrace, London, SW17 0RE.

Objectives: To investigate whether the longitudinal Doppler changes in small-for-gestational age (SGA) fetuses improves the prediction of those at risk of intrauterine fetal death (IUFD).

Methods: A longitudinal study using two cohorts of singleton pregnancies (SGA and appropriate for gestational age [AGA]). The inclusion criteria for the SGA cohort were singleton pregnancies at 20 weeks' gestation or beyond and diagnosed with SGA. Read More

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December 2018

Pressure pain sensitivity is associated with dental fear in adults in middle age: Findings from the Northern Finland 1966 birth cohort study.

Community Dent Oral Epidemiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Community Dentistry, University of Turku, Turku, Finland.

Introduction: Dental fear is a prevalent problem leading to severe deterioration of oral health and health-related quality of life. Despite the knowledge that dental fear is closely linked to painful experience, the association between pain sensitivity and dental fear remains unclear. This study was designed to evaluate this association with validated measures of dental fear and pressure pain sensitivity in a cohort population. Read More

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December 2018
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Valence matters: An electrophysiological study on how emotions influence cognitive performance in children.

Dev Psychobiol 2018 Dec 13. Epub 2018 Dec 13.

Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.

Emotional stimuli have been found to influence cognitive performance in children, but it is not clear whether this effect varies with the cognitive demands of the task. In this study, we examined how emotional expressions influenced cognitive performance and event-related potentials (ERPs) in early and middle childhood under varying cognitive control demands. Two groups of children (4. Read More

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December 2018
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