Search Our Scientific Publications & Authors

Addict Behav 2018 Nov 23;90:362-368. Epub 2018 Nov 23.

Department of Psychology, Rutgers University, Camden 311 North 5th Street, Camden NJ 08102, United States. Electronic address:

Previous research has demonstrated that caffeinated beverage consumption predicts alcohol consumption among early adolescents. This study aimed to investigate this association in two ways: (1) by examining if this association remained significant once other established risk factors for alcohol were adjusted for statistically; and (2) by considering three possible moderators of this association: gender, sensation-seeking, and parental monitoring. Data from the Camden Youth Development Study, a longitudinal, community-based study of middle-school students, were used. Read More

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Nov 7;1104:196-204. Epub 2018 Nov 7.

Department of Chemistry, Semnan University, Semnan 35195-363, Iran.

For the first time, three phase hollow fiber liquid phase microextraction using an influential, and green middle phase comprised a new relatively-hydrophobic deep eutectic solvent (three-phase HF-LPME-DES) was developed for trace analyses of antiarrhythmic drugs in biological and environmental samples. The extraction solvent was easily synthesized by mixing the green and cheap raw materials, namely choline chloride and 1-phenylethanol (ChCl: Ph-ETOH), in the ambient temperature. Good compatibility to pores of hollow-fiber, high ability for extraction of ionizable organic compounds with no need to any carrier agents, and easy availability in the laboratory environment turned this new proposed deep eutectic intermediate to a worthy generation of the supported liquid membrane (SLM). Read More

Midwifery 2018 Nov 19;69:163-171. Epub 2018 Nov 19.

Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA. Electronic address:

Objectives: Suboptimal breastfeeding contributes to morbidity and mortality in children. Studies in high-income countries (HICs) show that exclusive-breastfeeding (EBF) is associated with longer breastfeeding duration. The aim of this study was to determine whether maternal reports of EBF at six months are associated with longer duration of breastfeeding during the first two years of life in a low and middle-income country (LMIC) setting, and to identify determinants of breastfeeding duration. Read More

J Electromyogr Kinesiol 2018 Nov 28;44:64-69. Epub 2018 Nov 28.

Research Center of Health, Physical Fitness & Sports, Nagoya University, Nagoya, Japan; Graduate School of Education and Human Development, Nagoya University, Nagoya, Japan.

We aimed to test the hypothesis that the magnitude of differences in muscle activation of the knee and hip extensor muscles between high-intensity interval exercise (HIE) and moderate-intensity constant exercise (CE) would be greater for the gluteus maximus than for the quadriceps femoris muscle. Participants were 11 male middle- or long-distance runners. The HIE (4 sets, 4-min induration, performed at 80-85%VO and followed by a 3-min period of cycling at < 30%VO) and CE (28-min, performed at or near 60%VO) were completed on different days, with the total exercise duration and work being identical for both protocols. Read More

Int Immunopharmacol 2018 Dec 3;66:354-361. Epub 2018 Dec 3.

Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun 130033, China. Electronic address:

Background: Osteoarthritis is an age-related disorder of bone-joint that causes pain and disability in middle and older people. This study aimed to investigate the potential effects of long non-coding RNA (lncRNA) THRIL on lipopolysaccharide (LPS)-induced osteoarthritis cell injury model (ATDC5 cell inflammatory injury), as well as the possible internal molecular mechanisms.

Methods: Cell viability and apoptosis were assessed using CCK-8 assay and Guava Nexin assay, respectively. Read More

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurological Surgery, University of California, San Francisco, California, USA; Skull Base and Cerebrovascular Laboratory, University of California, San Francisco, California, USA. Electronic address: http://skullbaselab.ucsf.edu.

Introduction: Anterior-inferior cerebellar artery (AICA) aneurysms are rare with no optimal consensus on management strategies. When the treatment requires parent artery occlusion post-operative ischemic or neuropathic, complications can occur.

Objective: To evaluate the feasibility of direct revascularization of premeatal AICA using the middle meningeal artery (MMA) as the donor through an anterior petrosectomy (APA) window. Read More

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Middle East Technical University (METU), BIOMATEN Center of Excellence in Biomaterials and Tissue Engineering, Ankara 06800, Turkey; Middle East Technical University (METU), Graduate Department of Micro and Nanotechnology, Ankara 06800, Turkey; Middle East Technical University (METU), Department of Chemistry, Ankara 06800, Turkey. Electronic address:

Poly(ε-caprolactone) (PCL) is one of the most commonly used polymers in the production of tissue engineered scaffolds for hard tissue treatments. Incorporation of cells into these scaffolds significantly enhances the healing rate of the tissue. In this study, PCL scaffolds were prepared by wet spinning technique and modified by addition of fibrinogen in order to form a fibrin network between the PCL fibers. Read More

Prev Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Community Health Sciences, University of California, Los Angeles, United States of America.

Complex interrelationships between race, sex, obesity and depression have been well-documented. Because of differences in associations between socioeconomic status (SES) and health by race, determining the role of SES may help to further explicate these relationships. The aim of this study was to determine how race and income interact with obesity on depression. Read More

Acta Trop 2018 Dec 3. Epub 2018 Dec 3.

ICMR-National Institute of Malaria Research Field Unit Jablpur, Epidemiology, ICMR-NIRTH Campus, Nagpur Road, 482003, Jabalpur, Madhya Pradesh, India. Electronic address:

The cost burden of malaria at the household level, resulting from complex social, economic, and epidemiological factors, is enormous. This study was carried out to estimate the economic burden of malaria at the household level in low and high malaria transmission areas of central India. We conducted surveys with households in which at least one member had suffered from malaria in the three months preceding the survey. Read More

Exp Neurol 2018 Dec 3. Epub 2018 Dec 3.

Cellular Neurobiology Laboratories, The Salk Institute, La Jolla, CA, USA.

Ischemic stroke is an acute neurodegenerative disease that is extremely devastating to patients, their families and society. Stroke is inadequately treated even with endovascular procedures and reperfusion therapy. Using an extensive translational screening process, we have developed a pleiotropic cytoprotective agent with the potential to positively impact a large population of brain ischemia patients and revolutionize the process used for the development of new drugs to treat complex brain disorders. Read More

Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.

Purpose: To evaluate the influence of the height of the antrostomy on dimensional variations of the elevated space after sinus floor elevation.

Materials And Methods: Twenty-four healthy volunteers planned for sinus floor elevation were included in the study. An antrostomy of either 4 mm (Group A) or 8 mm (Group B) in height was prepared in the lateral wall of the sinus. Read More

PLoS One 2018 6;13(12):e0208525. Epub 2018 Dec 6.

Department of International Health and Collaboration, National Institute of Public Health, Saitama, Japan.

Objective: To examine the possibility of diagnosing the double burden of malnutrition using estimated deviation values in low- and lower-middle-income countries.

Methods: A modified version of the Japanese Diagnostic Tool was used. Data on 194 countries were analyzed, including data from the United Nations International Children's Fund, World Health Organization and World Bank. Read More

PLoS One 2018 6;13(12):e0208763. Epub 2018 Dec 6.

Division of Otolaryngology, Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

Clinicians commonly recommend increased hydration to patients with voice disorders. However, effects on clinical voice outcome measures have been inconsistent. Hydration-induced change within different layers of vocal fold tissue is currently unknown. Read More

PLoS One 2018 6;13(12):e0208435. Epub 2018 Dec 6.

Occupational and environmental medicine, Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Recurrent headache, abdominal and musculoskeletal pain are common in adolescents and it is therefore important to understand their impact on the transitional period from childhood to adulthood. However, studies of the prevalence over time and implications on educational outcomes are still limited, especially regarding multiple pain symptoms. The present study material consists of questionnaire surveys, completed in 2000 and 2008, including two study populations of 9th grade adolescents aged 15 living in West Sweden (n = 20 877). Read More

Folia Med Cracov 2018 ;58(3):83-87

Department of Internal Medicine, General Hospital of Veria, Veria, Greece.

Meckel's diverticulum represents a remnant of the proximal end of the omphalomesenteric duct, which constitutes a connection between the middle intestine and the vitelline vesicle. It is the most common congenital anomaly of the gastrointestinal tract and is found in approximately 0.3-2% of the general population. Read More

Med J Aust 2018 Dec;209(11):490-494

University of Sydney, Sydney, NSW.

Background: The Mamil (middle-aged man in Lycra) appears to be an emergent cycling-focused species.

Objectives: To explore the nature and distribution of the Mamilian species; to determine whether rates of cycling by middle-aged men in Australia have changed since the pre-Mamilian era.

Setting: Secondary analysis of representative population-based datasets. Read More

Brain Inj 2018 Dec 6:1-7. Epub 2018 Dec 6.

a Human Higher Nervous Activity Lab Moscow , Institute of Higher Nervous Activity and Neurophysiology of RAS , Moscow , Russia.

Primary Objective: We aimed to investigate the origin of EEG response of patients in coma and after moderate TBI to emotional stimulation, whether they distinguish emotional content or only react to the physical features of an audio signal.

Research Design: We registered EEG during continuous pleasant and unpleasant non-verbal stimulation and in rest. A total of 69 subjects participated in our study: healthy adults, conscious patients after moderate TBI and patients in coma after severe TBI. Read More

FASEB J 2018 Dec 6:fj201801127R. Epub 2018 Dec 6.

Institute of Molecular Medicine and Cell Research, Medical Faculty, University of Freiburg, Freiburg, Germany.

Tumor-initiating cells (TICs) existing in breast cancer are thought to be involved in initiation, progression, and relapse of tumors. In these processes, the epithelial-to-mesenchymal transition (EMT) and proteases are crucial factors that also dependent on the tumor milieu, including hypoxic nutrient-deprived, as well as normoxic nutrient-rich, environments. Therefore, we investigated EMT and proteases in TICs and their response to different environments by means of a newly generated immortalized TIC (iTIC) line. Read More

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Introduction: Prostate - specific antigen (PSA) is a useful biomarker for detection of prostate cancer (PCa) and for risk classification in addition to TNM classification and Gleason score (GS). We reported the role of PSA in patients with low (< 20 ng / mL) and extremely high (≥ 100 ng / mL) PSA levels. However, it is unclear whether a correlation exists between middle range PSA levels (20 - 100 ng / mL) at diagnosis and prognosis. Read More

Chemistry 2018 Dec 6. Epub 2018 Dec 6.

Zhejiang University, School of Materials Science and Engineering, 38 Zheda Road, 310027, Hangzhou, CHINA.

Developing high-efficiency electromagnetic (EM) wave absorbing materials with light weight, thin thickness and wide absorption bandwidth is highly desirable for ever-developing electronic and telecommunication devices. Herein, hierarchical metal-organic framework (MOF)-derived Co/C@V2O3 hollow spheres were designed and synthesized through a facile hydrothermal, precipitation and pyrolysis method. The composite exhibits both excellent impedance matching and light weight due to the rational combination of hollow V2O3 spheres and porous Co/C. Read More

Transbound Emerg Dis 2018 Dec 6. Epub 2018 Dec 6.

Food and Agriculture Organization (FAO), Regional Office for Europe and Central Asia, Budapest, Hungary.

Data from affected lumpy skin disease (LSD) locations between July 2012 and September 2018 in the Balkans, Caucasus and Middle East were retrieved from FAO's Global Animal Disease Information System (EMPRES-i) from the European Commission's Animal Disease Notification System (ADNS) and completed with data from the official veterinary services of some countries. During this period, a total of 7,593 locations from twenty-two countries were affected. Within this period, over 46,000 cattle were clinically affected by LSD, 3,700 animals died and 17,500 were slaughtered due to culling policies to stop the spread of the disease. Read More

Transbound Emerg Dis 2018 Dec 6. Epub 2018 Dec 6.

UAB, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.

The present study investigated the co-localization of the Middle East respiratory syndrome coronavirus (MERS-CoV) and its receptor dipeptidyl peptidase-4 (DPP4) across respiratory and lymphoid organs of experimentally MERS-CoV infected pigs and llamas by immunohistochemistry (IHC). Also, scanning electron microscopy (SEM) was performed to assess the ciliary integrity of respiratory epithelial cells in both species. In pigs, on day 2 post-inoculation (p. Read More

Saudi Med J 2018 Dec;39(12):1238-1241

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To determine the mean nasal skin thickness in the Middle Eastern population and to assess the effect of skin thickness on patients' satisfaction following rhinoplasty surgeries. Methods: Radiological measurements of skin thickness at the 3 vertical thirds of the nasal dorsum were taken. A total of 154 patients (80 females and 74 males) who were scheduled for computed tomography scan for the paranasal sinuses were included in the study. Read More

Soft Matter 2018 Dec 6. Epub 2018 Dec 6.

Department of Materials and Environmental Chemistry, Stockholm Universtity, Stockholm, Sweden.

Cholesterol is an essential component of all animal cell membranes and plays an important role in maintaining the membrane structure and physical-chemical properties necessary for correct cell functioning. The presence of cholesterol is believed to be responsible for domain formation (lipid rafts) due to different interactions of cholesterol with saturated and unsaturated lipids. In order to get detailed atomistic insight into the behaviour of cholesterol in bilayers composed of lipids with varying degrees of unsaturation, we have carried out a series of molecular dynamics simulations of saturated and polyunsaturated lipid bilayers with different contents of cholesterol, as well as well-tempered metadynamics simulations with a single cholesterol molecule in these bilayers. Read More

Psychol Med 2018 Dec 6:1-9. Epub 2018 Dec 6.

School of Traditional Chinese Medicine, Southern Medical University,Guangzhou,China.

Background: We hypothesize that the tumor necrosis factor-α (TNF-α) may play a role in disturbing the effect of selective serotonin reuptake inhibitor (SSRI) on the striatal connectivity in patients with major depressive disorder (MDD).

Methods: We performed a longitudinal observation by combining resting-state functional magnetic resonance imaging (rs-fMRI) and biochemical analyses to identify the abnormal striatal connectivity in MDD patients, and to evaluate the effect of TNF-α level on these abnormal connectivities during SSRI treatment. Eighty-five rs-fMRI scans were collected from 25 MDD patients and 35 healthy controls, and the scans were repeated for all the patients before and after a 6-week SSRI treatment. Read More

Psych J 2018 Dec 5. Epub 2018 Dec 5.

Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.

Prospective memory (PM) refers to the ability to remember to do something in the future. Implementation intention refers to a self-regulatory strategy in the form of "If …, then …" planning that can improve PM performance. However, the neural basis of the effect of implementation intention on PM remains unclear, as do the phases of PM that are affected by implementation intention. Read More

J Dermatol 2018 Dec 6. Epub 2018 Dec 6.

Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.

Atopic dermatitis is a chronic, relapsing, inflammatory skin disease that usually appears in early childhood and develops into a heterogeneous disease during childhood. The clinical course and treatment for atopic dermatitis can differ according to its phenotype and/or endotype. This study aimed to identify clinical phenotypes of atopic dermatitis in early childhood. Read More

Monogr Soc Res Child Dev 2018 Dec;83(4):35-59

This article investigated two central questions about mother-child attachment relationships during early childhood: (1) the association between maternal sensitivity and child attachment behavior (Study 1) and (2) the link between child attachment behavior and representations (Study 2). In Study 1, maternal sensitivity and child security were assessed in naturalistic contexts among 74 middle-class dyads, when children were about 3.5 and again 5. Read More

Neurotherapeutics 2018 Dec 5. Epub 2018 Dec 5.

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, 33 Queen Square, London, WC1E 6BT, UK.

Laser interstitial thermal therapy (LITT) is an alternative to open surgery for drug-resistant focal mesial temporal lobe epilepsy (MTLE). Studies suggest maximal ablation of the mesial hippocampal head and amygdalohippocampal complex (AHC) improves seizure freedom rates while better neuropsychological outcomes are associated with sparing of the parahippocampal gyrus (PHG). Optimal trajectories avoid sulci and CSF cavities and maximize distance from vasculature. Read More

Musculoskelet Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Orthopaedics, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, India.

Introduction: Open reduction and plate fixation is known to reduce chances of malunion and symptomatic nonunion in displaced middle-third clavicle fractures. However, this treatment modality is also associated with several complications, such as hardware irritation, numbness around the surgical scar, infection, nonunion and implant failure. The minimally invasive plate osteosynthesis (MIPO) technique may reduce these complications. Read More

Anal Bioanal Chem 2018 Dec 6. Epub 2018 Dec 6.

Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.

Capillary electrophoresis (CE) is excellent at separating all the ions in a sample but is rarely used as a result of its detection issue and easy loss of very fast ions by common one-end injection methods. Herein we propose a newly developed method aimed at simultaneous determination of positive and negative ions with a home-made CE device, featuring bi-end injection and contactless conductivity detection at the middle. By simply using 2. Read More

Neuroradiology 2018 Dec 5. Epub 2018 Dec 5.

ITAB-Institute of Advanced Biomedical Technologies, University "G. D'Annunzio" Chieti-Pescara, Chieti, Italy.

Purpose: To investigate modifications of Magnetic Resonance Diffusion Tensor Imaging (DTI) and Diffusion Kurtosis Imaging (DKI) metrics in lateral white matter (WM) bundles of the cervical spinal cord in patients with previous stroke in the vascular territory of the middle cerebral artery (MCA).

Methods: Twenty consecutive patients with a previous ischemic stroke of the MCA territory and a varying degree of upper motor impairment were enrolled. DKI was centered at the C3C4 and C5C6 intervertebral level. Read More

J Youth Adolesc 2018 Dec 5. Epub 2018 Dec 5.

Department of Psychology, University of California, Los Angeles, CA, 90095-1521, USA.

Cross-ethnic friendships are linked to a range of positive outcomes in adolescence, but have been shown to be lower quality and less stable than same-ethnic friendships. The current study examined how classroom diversity and out-of-school contact contribute to these relational differences between cross-and same-ethnic friendships. Multilevel analyses were conducted on a sample of 9,171 classroom-based friends nested within 4,333 ethnically diverse sixth grade students (54% female; 32% Latino, 20% White, 14% East/Southeast Asian, 12% African American, 14% Multiethnic, 8% Other ethnic). Read More

Glob Health Res Policy 2018 22;3:34. Epub 2018 Nov 22.

3New York University Rory Meyers College of Nursing, New York, NY USA.

Background: Migration is a fundamental demographic process that has been observed globally. It is suggested that migration is an issue of global health importance that can have an immediate and lasting impact on an individual's health and well-being. There is now an increasing body of evidence linking migration with cognitive function in older adults. Read More

Data Brief 2018 Dec 3;21:1880-1885. Epub 2018 Nov 3.

Iqra University, Pakistan.

Data were collected from administration officers ranging from middle-management to top management of the five universities of Malaysia. The data was collected through a standardized and structured questionnaire. The variables of the study were religiosity, personality and work behavior of Muslims. Read More

J Hepatocell Carcinoma 2018 8;5:99-108. Epub 2018 Nov 8.

Department of Cellular Pathology, Royal Free Hospital, London NW3 2QG, UK,

Histopathologists retain a critical role in the diagnosis and management of hepatocellular carcinoma (HCC). HCC arises usually but not exclusively in a background of advanced-stage chronic liver disease. The histological diagnosis of HCC poses many challenges particularly when dealing with liver biopsy specimens due to the heterogeneity of HCC and the difficulty to confirm hepatocellular differentiation in some instances. Read More

Respirol Case Rep 2019 Feb 30;7(2):e00393. Epub 2018 Nov 30.

Department of Respiratory Medicine Kyorin University School of Medicine Tokyo Japan.

A 17-year-old woman was referred to our hospital due to cough on exertion and right chest pain over the previous two months, together with bloody sputum over the previous week. Chest X-ray demonstrated a nodule measuring 3 cm in diameter in the right middle lung field. On repeated bronchoscopy, the tumour was recognized as a rapidly growing intra-bronchial protruded tumour at the orifice of the right B8. Read More

Ecol Evol 2018 Nov 25;8(22):11213-11223. Epub 2018 Oct 25.

Department of Biology Middle Tennessee State University Murfreesboro Tennessee.

Human activities have substantially increased atmospheric nitrogen (N) deposition in ecosystems worldwide, often leading to higher plant quality for herbivores and greater herbivory. Predators frequently suppress herbivores and indirectly benefit plants via "trophic cascades", and the strength of these interactions can also depend on N availability. However, the evidence for N deposition effects on cascades primarily comes from studies of high-level N deposition. Read More

Ecol Evol 2018 Nov 25;8(22):10902-10913. Epub 2018 Oct 25.

Pearl River Fisheries Research Institute CAFS Guangzhou China.

Biotic-environment interactions have long been considered an important factor in functional phenotype differentiation in organisms. The differentiation processes determining functional phenotypes can reveal important mechanisms yielding differences in specific functions of animal traits in the ecosystem. In the present study, we examined functional morphological variations in relation to increasing geographic altitude. Read More

Stand Genomic Sci 2018 29;13:35. Epub 2018 Nov 29.

1Center of Food Safety and Applied Nutrition, U. S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708 USA.

is a Gram-negative opportunistic pathogen that causes life- threatening infantile infections, such as meningitis, septicemia, and necrotizing enterocolitis, as well as pneumonia, septicemia, and urinary tract and wound infections in adults. Here, we report 26 draft genome sequences of , which were obtained from dried spices from the USA, the Middle East, China, and the Republic of Korea. The average genome size of the genomes was 4393 kb, with an average of 4055 protein coding genes, and an average genome G + C content of 56. Read More

J Cancer 2018 20;9(22):4287-4293. Epub 2018 Oct 20.

State Key Laboratory of Oncology in South China, Department of Experimental Research, Sun Yat-sen University Cancer Center, No. 651 Dongfeng East Road, Guangzhou 510060, China.

Esophageal squamous cell carcinoma (ESCC) is a malignant epithelial tumor with a high incidence in East Asia and the Middle East. The outcomes for ESCC patients are usually not optimal due to the recurrence and metastasis. This study is aim to examine the expression and the prognostic value of LAG-3 in ESCC. Read More

Int J Telemed Appl 2018 1;2018:9602821. Epub 2018 Nov 1.

Department of Clinical Medicine, Faculty of Health Sciences, The Arctic University of Norway (UiT), N-9037 Tromsø, Norway.

Introduction: The rising incidence of mental illness and its impact on individuals, families, and societies is becoming a major public health concern, especially in resource-constrained countries. Consequently, there is an increasing demand for mental health services in many middle- and low-income countries (LMIC). Challenges such as inequality in access, lack of staff and hospital beds, and underfunding, often present in the LMIC, might in part be addressed by telemental health services. Read More

Front Immunol 2018 16;9:2583. Epub 2018 Nov 16.

Department of Gastroenterology, Bethune First Affiliated Hospital of Jilin University, Changchun, China.

Systemic Epstein-Barr virus-positive T-cell lymphoproliferative childhood disease (EBV+ T-LPD) is extremely rare. Primary acute or chronic active Epstein-Barr virus infection triggers EBV+ T-LPD's onset and the disease involves clonal proliferation of infected T-cells with activated cytotoxic phenotype. The adult-onset EBV+ T-LPD (ASEBV+ T-LPD) is even rarer and needs to be extensively studied. Read More

Front Microbiol 2018 21;9:2821. Epub 2018 Nov 21.

State Key Laboratory of Ocean Engineering, Institute of Oceanography, Shanghai Jiao Tong University, Shanghai, China.

The benthic boundary layer (BBL) is the part of the water column that is situated near to the sediment surface, where active oceanic biogeochemical cycling occurs. Archaea play an important role in mediating this cycling, however, their composition and diversity in the BBL remain largely unknown. We investigated the community composition and abundance of both particle-attached (PA) and free-living (FL) archaea in the BBL on the slopes of the Mariana Trench using Illumina sequencing and quantitative PCR (qPCR), at both the DNA and RNA levels. Read More

Front Physiol 2018 21;9:1657. Epub 2018 Nov 21.

Centre for Heart Lung and Vascular Health, School of Health and Exercise Science, University of British Columbia Okanagan, Kelowna, BC, Canada.

Exercise has been shown to induce cerebrovascular adaptations. However, the underlying temporal dynamics are poorly understood, and regional variation in the vascular response to exercise has been observed in the large cerebral arteries. Here, we sought to measure the cerebrovascular effects of a single 20-min session of moderate-intensity exercise in the one hour period immediately following exercise cessation. Read More

Front Neurosci 2018 15;12:827. Epub 2018 Nov 15.

Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.

Sleep disturbances, such as early wakening, are frequently observed in patients with major depressive disorder (MDD). The suprachiasmatic nuclei (SCN), which controls circadian rhythm, is innervated by the raphe nucleus, a region where Tryptophan hydroxylase-2 (TPH-2) gene is primarily expressed. Although TPH-2 is often implicated in the pathophysiology of depression, few studies have applied a genetic and imaging technique to investigate the mechanism of early wakening symptom in MDD. Read More

Cell Death Dis 2018 Dec 5;9(12):1173. Epub 2018 Dec 5.

Department of General Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 301 Middle Yan' Chang Road, 200072, Shanghai, P. R. China.

Mast cells (MCs) are potent tissue-resident immune cells that are distributed in the intraepithelial space of the intestine and have been implicated in regulating immune homeostasis and coordinating epithelial responses in inflamed mucosa of inflammatory bowel disease (IBD). IL-33 functions as an endogenous danger signal or alarmin in inflamed intestine segments. MCs highly express the IL-33 receptor ST2. Read More

Pediatr Res 2018 Dec 5. Epub 2018 Dec 5.

Keck School of Medicine of University of Southern California, Division of Neonatology, Department of Pediatrics, LAC+USC Medical Center, Los Angeles, CA, USA.

Neonatal hyperbilirubinemia is one of the most frequent diagnoses made in neonates. A high level of unconjugated bilirubin that is unbound to albumin is neurotoxic when the level exceeds age-specific thresholds or at lower levels in neonates with neurotoxic risk factors. Lower range of unbound bilirubin results in apoptosis, while moderate-to-high levels result in neuronal necrosis. Read More