1,777 results match your criteria Microscopic Polyangiitis


Clinical characteristics of patients with granulomatosis with polyangiitis and microscopic polyangiitis in ENT practice: a comparative analysis.

Acta Otorhinolaryngol Ital 2018 Dec;38(6):517-527

Department and Clinic of Otolaryngology, Head and Neck Surgery, Wrocław Medical University Hospital, Borowska, Poland.

ENT manifestations are commonly observed in patients with small vessel vasculitis (SVV). The main aim of this study was to analyse and present the clinicopathological characteristics of individuals with SVV emphasising otorhinolaryngological symptoms. This study evaluated 64 patients, 41 with granulomatosis with polyangiitis (GPA) and 23 with microscopic polyangiitis (MPA). Read More

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http://dx.doi.org/10.14639/0392-100X-1776DOI Listing
December 2018

Molecular targeted therapies for microscopic polyangiitis and granulomatosis with polyangiitis.

Korean J Intern Med 2019 Jan 9. Epub 2019 Jan 9.

Department of Rheumatology, Ome Municipal General Hospital, Tokyo, Japan.

Clinical trials and observational studies have established cyclophosphamide (CY) or rituximab plus glucocorticoid (GC) as standard remission induction therapies in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). However, because these regimens are associated with serious adverse drug reactions, the development of drugs with novel mechanisms of actions are needed. Progress in basic and clinical research has identified novel candidate targeting molecules, including B-cell activating factor (BAF), C5a receptor, and interleukin-6. Read More

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http://kjim.org/journal/view.php?doi=10.3904/kjim.2018.366
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http://dx.doi.org/10.3904/kjim.2018.366DOI Listing
January 2019
4 Reads

[Comparison of disease activities and extent measurements for anti-neutrophil cytoplasmic autoantibody-associated vasculitis].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1022-1026

Department of Rheumatology, Fouth Medical Center of PLA General Hospital, Beijing 100048, China.

Objective: To investigate the significance of a set of seven disease activities and extension measurements and their correlations between one and another for anti-neutrophil cytoplasmic autoantibody associated vasculitis (AAV).

Methods: A total of 121 patients from Peking University International Hospital and Fouth Medical Center of PLA General Hospital with confirmed diagnoses of AAV clinically were enrolled in the study, including 15 cases of eosinophilic granulomatous with polyangiitis (EGPA), 59 cases of granulomatous with polyangiitis (GPA) and 47 cases of microscopic polyangiitis (MPA). A hundred and twenty-one AAV patients were divided into death group and survival group according to their survival conditions. Read More

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December 2018

Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Korea: A Narrative Review.

Yonsei Med J 2019 Jan;60(1):10-21

Division of Rheumatology, Department of Internal Medicine, and Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea.

Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a group of systemic necrotising vasculitides, which often involve small vessels, and which lead to few or no immune deposits in affected organs. According to clinical manifestations and pathological features, AAV is classified into three variants: microscopic polyangiitis, granulomatosis with polyangiitis (GPA), and eosinophilic GPA. The American College of Rheumatology 1990 criteria contributed to the classification of AAV, although currently the algorithm suggested by the European Medicines Agency in 2007 and the Chapel Hill Consensus Conference Nomenclature of Vasculitides proposed in 2012 have encouraged physicians to classify AAV patients properly. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3349/ymj.2019.60
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http://dx.doi.org/10.3349/ymj.2019.60.1.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298898PMC
January 2019
4 Reads

No overlap between IgG4-related disease and microscopic polyangiitis and granulomatosis with polyangiitis despite elevated serum IgG4 at diagnosis: a retrospective monocentric study.

Clin Rheumatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.

Objectives: We investigated whether elevated serum IgG4 at the time of diagnosis of microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) may be associated with concurrent IgG4-related disease (IgG4-RD) in immunosuppressive drug-naïve patients.

Methods: We retrospectively reviewed the medical records of 46 MPA and GPA patients with results on serum IgG4 and histology at diagnosis. Elevated serum IgG4 was defined as IgG4 > 135 mg/dL. Read More

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http://dx.doi.org/10.1007/s10067-018-4402-xDOI Listing
December 2018

Pathogenesis and therapeutic interventions for ANCA-associated vasculitis.

Nat Rev Rheumatol 2018 Dec 12. Epub 2018 Dec 12.

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) affects systemic small vessels and is accompanied by the presence of ANCAs in the serum. This disease entity includes microscopic polyangiitis, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis and drug-induced AAV. Similar to other autoimmune diseases, AAV develops in patients with a predisposing genetic background who have been exposed to causative environmental factors. Read More

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http://dx.doi.org/10.1038/s41584-018-0145-yDOI Listing
December 2018

Antineutrophil cytoplasmic antibody-associated vasculitis, update on molecular pathogenesis, diagnosis, and treatment.

Int J Nephrol Renovasc Dis 2018 22;11:313-319. Epub 2018 Nov 22.

Department of Medicine, Division of Nephrology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA,

Circulating antineutrophil cytoplasmic antibodies (ANCAs) are the central pathogenic mechanism for a group of systemic and renal syndromes called the ANCA-associated vasculitis (AAV). The nomenclature has changed from eponymous labeling to granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, and microscopic polyangiitis. These syndromes predominantly affect the pulmonary and renal systems. Read More

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http://dx.doi.org/10.2147/IJNRD.S162071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255047PMC
November 2018
2 Reads

European consensus-based recommendations for the diagnosis and treatment of rare paediatric vasculitides - the SHARE initiative.

Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.

Department of Paediatric Rheumatology, Alder Hey Children's Hospital, Liverpool, UK.

Objectives: The European initiative Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) aimed to optimize care for children with rheumatic diseases. Systemic vasculitides are very rare in children. Consequently, despite recent advances, paediatric-specific information is sparse. Read More

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/key322DOI Listing
December 2018
9 Reads

Update on the epidemiology, risk factors, and outcomes of systemic vasculitides.

Best Pract Res Clin Rheumatol 2018 04 2;32(2):271-294. Epub 2018 Nov 2.

Department of Rheumatology, Hospital of Bruneck, Bruneck, Italy; Department of Rheumatology and Immunology, Medical University Graz, Graz, Austria.

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and giant cell arteritis (GCA) are the most common primary systemic vasculitides of the adult population, while polymyalgia rheumatica (PMR) is a clinical syndrome often associated with GCA. Incidence and prevalence rates of AAV have been increasing in the last decades, whereas those of GCA and PMR have remained stable. The mutual interplay between environmental and genetic risk factors leading to the development of these diseases has been further analyzed in the last years. Read More

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http://dx.doi.org/10.1016/j.berh.2018.09.001DOI Listing
April 2018
1 Read

Investigations in systemic vasculitis - The role of imaging.

Best Pract Res Clin Rheumatol 2018 02 25;32(1):63-82. Epub 2018 Sep 25.

University Hospital Gasthuisberg, Herestraat 49, B3000, Leuven, Belgium. Electronic address:

Imaging plays an increasing role for confirming a suspected diagnosis of giant cell arteritis (GCA) or Takayasu arteritis (TAK). Ultrasound, magnetic resonance imaging (MRI), and computed tomography demonstrate a homogeneous, most commonly concentric, arterial wall thickening. 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) displays increased FDG uptake of inflamed artery walls delineating increased metabolism. Read More

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http://dx.doi.org/10.1016/j.berh.2018.08.009DOI Listing
February 2018
1 Read

Rupture of Multiple Hepatic Artery Microaneurysms in Microscopic Polyangiitis.

J Rheumatol 2018 Dec;45(12):1705

Department of Rheumatology and Clinical Immunology, Kobe University Hospital, Kobe, Japan.

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http://dx.doi.org/10.3899/jrheum.180276DOI Listing
December 2018
1 Read

Aging in Primary Systemic Vasculitis: Implications for Diagnosis, Clinical Manifestations, and Management.

Drugs Aging 2019 01;36(1):53-63

Rheumatology Department, Policlinico S. Matteo, Fondazione IRCCS, University of Pavia, Pavia, Italy.

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) usually affect adults and older populations. The well recognized clinical (i.e. Read More

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http://dx.doi.org/10.1007/s40266-018-0617-4DOI Listing
January 2019
1 Read

Incidence and risk factors of new-onset hypertrophic pachymeningitis in patients with anti-neutrophil antibody-associated vasculitis: using logistic regression and classification tree analysis.

Clin Rheumatol 2018 Nov 27. Epub 2018 Nov 27.

Department of Nephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minatoku, 105-8470, Japan.

Objectives: Hypertrophic pachymeningitis (HP) is a rare complication in patients with anti-neutrophil antibody-associated vasculitis (AAV); its clinical features, incidence, and risk factors remain unknown. We aimed to clarify the prevalence, clinical features, and factors associated with new-onset HP in patients with AAV.

Method: A retrospective cohort study involving 93 patients with AAV was conducted. Read More

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http://dx.doi.org/10.1007/s10067-018-4372-zDOI Listing
November 2018
1 Read

Microscopic polyangiitis secondary to Mycobacterium abscessus in a patient with bronchiectasis: a case report.

BMC Pulm Med 2018 Nov 19;18(1):170. Epub 2018 Nov 19.

Centre for Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland.

Background: Non-Tuberculous Mycobacterial-pulmonary disease (NTM-PD) is increasing in incidence and prevalence. Mycobacterium abscessus (M.abscessus) is a rapid growing multi-resistant NTM associated with severe NTM-PD requiring prolonged antibiotic therapy. Read More

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http://dx.doi.org/10.1186/s12890-018-0732-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245610PMC
November 2018
8 Reads

Pulmonary vasculitis.

J Thorac Dis 2018 Sep;10(9):5560-5575

Interdisciplinary Research Group in Pneumology, Institute of Sanitary Research of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.

Systemic vasculitides frequently affect the pulmonary vasculature. As the signs and symptoms of pulmonary vasculitis are variable and nonspecific, diagnosis and treatment represent a real challenge. Vasculitides should be given consideration, as these diseases present severe manifestations of rapidly progressing pulmonary disease. Read More

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http://dx.doi.org/10.21037/jtd.2018.08.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196209PMC
September 2018
4 Reads

Prognostic Factors for Survival and Relapse in ANCA-Associated Vasculitis with Renal Involvement: A Clinical Long-Term Follow-Up Study.

Int J Nephrol 2018 16;2018:6369814. Epub 2018 Oct 16.

Abdomen Center, Nephrology, Helsinki University Hospital, Helsinki, Finland.

Aim: We describe the clinical pattern of ANCA-associated vasculitis (AAV) and assess long-term prognostic factors of patients and renal survival and relapse.

Methods: Data from 85 patients with renal biopsy-proven AAV at a single center with up to 20-year [median 16.2 years (95% CI 14. Read More

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https://www.hindawi.com/journals/ijn/2018/6369814/
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http://dx.doi.org/10.1155/2018/6369814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206576PMC
October 2018
20 Reads

Alveolar Hemorrhage in Vasculitis (Primary and Secondary).

Semin Respir Crit Care Med 2018 Aug 7;39(4):482-493. Epub 2018 Nov 7.

Department of Respiratory Medicine, Hospices Civils de Lyon, National Reference Center for Rare Pulmonary Diseases, Lyon, France.

Defined by the accumulation of red blood cells into the alveolar space, diffuse alveolar hemorrhage (DAH) is a severe and potentially fatal medical condition requiring careful attention. In contrast to simple extravasation of erythrocytes facilitated by impaired hemostasis or hemodynamic causes, DAH in vasculitis is due to capillaritis, that is, inflammation of capillaries. Dyspnea, hemoptysis, chest infiltrates, and abrupt fall of blood hemoglobin level represent the cardinal features of DAH; yet, hemoptysis is lacking in one-third of cases. Read More

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http://dx.doi.org/10.1055/s-0038-1668533DOI Listing
August 2018
13 Reads

Antineutrophil Cytoplasmic Antibody-Associated Lung Fibrosis.

Semin Respir Crit Care Med 2018 Aug 7;39(4):465-470. Epub 2018 Nov 7.

Assistance Publique Hôpitaux de Paris, Bichat Hospital, Rare Pulmonary Diseases Reference Center, Paris, France.

Pulmonary fibrosis is observed in a substantial number of patients with ANCA-associated vasculitis (AAV), 15% in a recent German series, and may be more frequent in Asian populations. ANCA are usually of anti-MPO specificity and microscopic polyangiitis is the most frequent vasculitis. Pulmonary fibrosis may increase the risk of death in patients with AAV. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1669914
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http://dx.doi.org/10.1055/s-0038-1669914DOI Listing
August 2018
5 Reads

Microscopic Polyangiitis: New Insights into Pathogenesis, Clinical Features and Therapy.

Authors:
Alexandre Karras

Semin Respir Crit Care Med 2018 Aug 7;39(4):459-464. Epub 2018 Nov 7.

Department of Nephrology, Hôpital Européen Georges Pompidou, Assistance Publique- Hôpitaux de Paris, Paris France.

Microscopic polyangiitis (MPA) is one of the main clinical presentations of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Although the disease is defined by clinical and pathological criteria, the anti-myeloperoxidase (MPO) specificity of ANCAs is observed in almost 80% of MPA patients. The direct pathogenic role of anti-MPO antibodies has been proven in animal models, in which the disease was transmitted by transfer of anti-MPO antibodies or anti-MPO-specific splenocytes. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1673387
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http://dx.doi.org/10.1055/s-0038-1673387DOI Listing
August 2018
6 Reads

Diffuse Alveolar Hemorrhage and Pulmonary Vasculitides: Histopathologic Findings.

Semin Respir Crit Care Med 2018 Aug 7;39(4):425-433. Epub 2018 Nov 7.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.

Vasculitides are a heterogeneous group of disorders in which inflammation of blood vessel walls is present at least some time during the course of the disease. Vasculitides can affect any caliber or type of vessel in many anatomic sites; however, the disease can alter more than just vasculature. Given the diversity of vasculitides, in 2012, a revised classification system was proposed to categorize vasculitides by the type of vessel involved including size, function, and structural attributes. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1669412
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http://dx.doi.org/10.1055/s-0038-1669412DOI Listing
August 2018
10 Reads

Pathogenesis of ANCA-Associated Pulmonary Vasculitis.

Semin Respir Crit Care Med 2018 Aug 7;39(4):413-424. Epub 2018 Nov 7.

University of North Carolina Kidney Center, Chapel Hill, North Carolina.

Antineutrophil cytoplasmic antibodies (ANCAs) are autoantibodies specific for antigens located in the cytoplasmic granules of neutrophils and lysosomes of monocytes. ANCAs are associated with a spectrum of necrotizing vasculitis that includes granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis. Pulmonary vasculitis and related extravascular inflammation and fibrosis are frequent components of ANCA vasculitis. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1673386
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http://dx.doi.org/10.1055/s-0038-1673386DOI Listing
August 2018
9 Reads

Immune-Mediated Systemic Vasculitis as the Proposed Cause of Sudden-Onset Sensorineural Hearing Loss following Lassa Virus Exposure in Cynomolgus Macaques.

MBio 2018 Oct 30;9(5). Epub 2018 Oct 30.

Office of the Chief Scientists, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA

Lassa virus (LASV) causes a severe, often fatal hemorrhagic disease in regions in Africa where the disease is endemic, and approximately 30% of patients develop sudden-onset sensorineural hearing loss after recovering from acute disease. The causal mechanism of hearing loss in LASV-infected patients remains elusive. Here, we report findings after closely examining the chronic disease experienced by surviving macaques assigned to LASV exposure control groups in two different studies. Read More

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http://dx.doi.org/10.1128/mBio.01896-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212830PMC
October 2018
2 Reads

Azathioprine Hypersensitivity Syndrome in a Cohort of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Patients.

J Allergy Clin Immunol Pract 2018 Oct 24. Epub 2018 Oct 24.

Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

Background: Azathioprine hypersensitivity syndrome is a rare complication of azathioprine therapy. Its symptoms resemble infection or relapse of inflammatory disease, hindering correct diagnosis. Current literature is limited to sporadic case reports and reviews. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132198183067
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http://dx.doi.org/10.1016/j.jaip.2018.10.018DOI Listing
October 2018
14 Reads

[Vasculitides and eosinophilic pulmonary diseases].

Z Rheumatol 2018 Dec;77(10):907-922

Abt. für Rheumatologie, Immunologie und Rehabilitation, Kantonsspital St. Gallen, St. Gallen, Schweiz.

Eosinophilic granulocytes form peripheral effector cells controlled by Th2 lymphocytes, which cause local cell, tissue, and functional disorders of infiltrated organs via the release of cytotoxic basic proteins and oxygen radicals. Diseases associated with eosinophilia include systemic and organ-related forms. The lungs are involved in eosinophilic granulomatosis with polyangiitis (EGPA, formerly known as Churg-Strauss syndrome), acute and chronic eosinophilic pneumonia, as well as in an organ manifestation in hypereosinophilic syndrome and certain parasitic diseases. Read More

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http://link.springer.com/10.1007/s00393-018-0561-z
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http://dx.doi.org/10.1007/s00393-018-0561-zDOI Listing
December 2018
11 Reads

Successful treatment outcomes in pregnant patients with ANCA-associated vasculitides: A systematic review of literature.

Int J Rheum Dis 2018 Sep;21(9):1734-1740

Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Aim: Antineutrophil cytoplasmic antibody-associated vasculitides (AAV) are a group of small vessel vasculitis with systemic presentations and considerable morbidity and mortality. Pregnancy in these patients poses a significant therapeutic challenge. There is limited published literature regarding pregnancy in AAV. Read More

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http://dx.doi.org/10.1111/1756-185X.13342DOI Listing
September 2018
1 Read
1.771 Impact Factor

Remission of Microscopic Polyangiitis Using Traditional Chinese Medicine: A Case Report.

Explore (NY) 2018 11 2;14(6):430-434. Epub 2018 Aug 2.

Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China. Electronic address:

Microscopic polyangiitis (MPA) is a systemic disease described as necrotizing vasculitis that affects capillaries, venules and arterioles. Hormone-based immunosuppression therapy is the common treatment, but with severe side effects. Hence, non-hormone or low-hormone therapies may be another option. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15508307183013
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http://dx.doi.org/10.1016/j.explore.2018.05.003DOI Listing
November 2018
9 Reads

Is granulomatosis with polyangiitis in Asia different from the West?

Int J Rheum Dis 2018 Oct 18. Epub 2018 Oct 18.

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

The incidence and clinical features of antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) have been shown to vary according to geographical areas, with granulomatosis with polyangiitis (GPA) being more common in northern Europe and microscopic polyangiitis (MPA) being more common in Asian countries. The annual incidence of GPA among Asians varies between 0.37/million to 2. Read More

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http://doi.wiley.com/10.1111/1756-185X.13398
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http://dx.doi.org/10.1111/1756-185X.13398DOI Listing
October 2018
8 Reads
1.771 Impact Factor

antineutrophil cytoplasmic antibody-associated vasculitis in pregnancy: a systematic review on maternal, pregnancy and fetal outcomes.

Clin Kidney J 2018 Oct 15;11(5):659-666. Epub 2018 Mar 15.

Division of Nephrology, Department of Medicine, Queen's University, Kingston, ON, Canada.

Background: antineutrophil cytoplasmic antibody-associated vasculitis typically arises in post-reproductive years, but can occur during pregnancy. Concerns of treatment-related teratogenicity persist, while efficacy and safety of new therapies including intravenous immunoglobulin (IVIG) and rituximab are uncertain. There remains a paucity of maternal, fetal and pregnancy outcome data in these women, and therefore a lack of guidance on safe treatment for clinicians. Read More

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https://academic.oup.com/ckj/article/11/5/659/4938690
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http://dx.doi.org/10.1093/ckj/sfy011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165750PMC
October 2018
3 Reads

Microscopic polyangiitis after streptococcal pharyngitis in a young woman.

Postgrad Med J 2018 Oct 3. Epub 2018 Oct 3.

Department of Internal Medicine, University Hospital of Heraklion, Heraklion, Greece.

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http://dx.doi.org/10.1136/postgradmedj-2018-135674DOI Listing
October 2018
2 Reads

Renal Involvement in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Rheum Dis Clin North Am 2018 11 7;44(4):525-543. Epub 2018 Sep 7.

Division of Nephrology, Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, 101 Merrimac Street, Boston, MA 02114, USA. Electronic address:

Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is the most common cause of rapidly progressive glomerulonephritis. ANCAs play an important role in the pathogenesis and diagnosis of AAV. The classic renal lesion in AAV is a pauci-immune necrotizing and crescentic glomerulonephritis. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.001DOI Listing
November 2018
9 Reads

Increased ischemic stroke, acute coronary artery disease and mortality in patients with granulomatosis with polyangiitis and microscopic polyangiitis.

J Autoimmun 2019 Jan 17;96:134-141. Epub 2018 Sep 17.

Université de Toulouse Paul Sabatier, Toulouse, France; Service de Médecine Interne, CHU Toulouse Purpan, Toulouse, France.

Objective: The aim of our study was to assess major cardiovascular event incidence, predictors, and mortality in ANCA-associated vasculitis (AAV).

Methods: We conducted a retrospective cohort study of all GPA or MPA, according to Chapel Hill Consensus Conference classification criteria, diagnosed between 1981 and 2015. Major cardiovascular event was defined as acute coronary artery disease, or ischemic stroke, or peripheral vascular disease requiring a revascularization procedure. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.09.004DOI Listing
January 2019
2 Reads

Clinical role of albumin to globulin ratio in microscopic polyangiitis: a retrospective monocentric study.

Clin Rheumatol 2018 Sep 15. Epub 2018 Sep 15.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

We investigated whether albumin to globulin ratio (AGR) at diagnosis may be associated with all-cause mortality in immunosuppressive drug-naïve patients with microscopic polyangiitis (MPA). We retrospectively reviewed the medical records of 88 MPA patients, who were first classified and in whom medications was first initiated in our tertiary Hospital. We collected clinical and laboratory data as well as the rate of all-cause mortality. Read More

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http://link.springer.com/10.1007/s10067-018-4292-y
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http://dx.doi.org/10.1007/s10067-018-4292-yDOI Listing
September 2018
4 Reads

Impact of MPO-ANCA mediated oxidative imbalance on renal vasculitis.

Am J Physiol Renal Physiol 2018 09 12. Epub 2018 Sep 12.

Internal Medicine, Multi-Organic Diseases, Montpellier University Hospital, France.

Glomerulonephritis is a severe complication of microscopic polyangiitis (MPA), a small-vessel vasculitis associated with anti-myeloperoxidase antibodies (MPO-ANCA). We previously showed the pathogenic effects of MPO-ANCA that activate MPO to trigger an oxidative burst mainly through HOCl production, contributing to endothelial injury and lung fibrosis. The aim of this study was to investigate the relationship between MPO-induced oxidative stress, anti-oxidant defenses and renal histological lesions in MPA patients. Read More

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http://dx.doi.org/10.1152/ajprenal.00111.2018DOI Listing
September 2018
2 Reads

Targeted immunotherapy strategies in ANCA-associated vasculitis.

Authors:
Xavier Puéchal

Joint Bone Spine 2018 Sep 7. Epub 2018 Sep 7.

Centre de référence des maladies systémiques auto-immunes rares, département de médecine interne, hôpital Cochin, Assistance publique-Hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France; Université Paris Descartes, 12, rue de l'École-de-Médecine, 75006 Paris, France; Institut Cochin, Inserm U1016, CNRS UMR 8104, Paris, France. Electronic address:

Targeted immunotherapy is substantially improving the management of ANCA-associated vasculitides (AAV), which include granulomatosis with polyangiitis (GPA, Wegener's granulomatosis), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss syndrome). This article reviews the current role for targeted immunotherapy in AAV, its validated indications, and avenues for further development. Rituximab is a validated induction treatment for GPA and severe MPA. Read More

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http://dx.doi.org/10.1016/j.jbspin.2018.09.002DOI Listing
September 2018
8 Reads

Case Report: Patient with Hepatitis C, p-ANCA, and Cryoglobulin Antibodies Presenting with Necrotizing Crescentic p-ANCA Glomerulonephritis.

Case Rep Nephrol Dial 2018 May-Aug;8(2):161-170. Epub 2018 Aug 10.

UCLA David Geffen School of Medicine, Westwood, California, USA.

Hepatitis C (HCV) infection has a prevalence of 3 million infected individuals in the United States, according to recent Center for Disease Control reports, and can have various renal manifestations. Cryoglobulins, antibodies that precipitate at colder temperatures in vitro, are a relatively common cause of renal disease in HCV infection. The cryoglobulin proteins can form occlusive aggregates in small glomerular capillary lumina or deposit in other areas of the glomerulus, resulting in hypocomplementemia, proteinuria, hematuria, and renal injury. Read More

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https://www.karger.com/Article/FullText/491629
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http://dx.doi.org/10.1159/000491629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120379PMC
August 2018
7 Reads

Microscopic polyangiitis after alemtuzumab treatment in relapsing-remitting MS.

Neurol Neuroimmunol Neuroinflamm 2018 Sep 10;5(5):e488. Epub 2018 Aug 10.

Department of Neurology (E.M.S., D.H.L., and R.A.L.), Department of Dermatology (S.S.), and Department of Internal Medicine-Rheumatology and Immunology (B.M.), Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117188PMC
September 2018
2 Reads

Pulmonary disorders that are potentially associated with anti- neutrophilic cytoplasmic antibodies: A brief review.

Authors:
Mark R Wick

Semin Diagn Pathol 2018 Sep 24;35(5):304-314. Epub 2018 Aug 24.

Division of Surgical Pathology and Cytopathology, University of Virginia Medical Center, Charlottesville, VA, United States. Electronic address:

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis frequently manifests with involvement of the lungs and kidneys, and it also may affect other anatomic sites. This article presents the patterns of pulmonary injury in which ANCA-associated vasculitis is included in the differential diagnosis, with a discussion of antineutrophil cytoplasmic antibody testing methods. The histologic features of non-vasculitic, potentially-ANCA-associated pulmonary lesions are reviewed briefly as well. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.08.005DOI Listing
September 2018
2 Reads

Vasculitis research: Current trends and future perspectives.

Int J Rheum Dis 2018 Aug 30. Epub 2018 Aug 30.

Department of Internal Medicine, Clinical Immunology and Rheumatology Services, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

We discuss recent and prospective research in small and large vessel vasculitis. Large cohorts of Takayasu arteritis (TA) have been recently published from across the world, clarifying our understanding of this uncommon disease. Novel open-ended approaches like large-scale genotyping, proteomics and metabolomics have helped gain novel insights into TA, giant cell arteritis (GCA) and anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). Read More

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http://dx.doi.org/10.1111/1756-185X.13370DOI Listing
August 2018
1 Read
1.771 Impact Factor

Primary Vasculitis in Childhood: GPA and MPA in Childhood.

Front Pediatr 2018 16;6:226. Epub 2018 Aug 16.

The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Childhood onset anti-neutrophilic cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a rare group of primary systemic vasculitides affecting medium and small blood vessels. AAV includes granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA), and renal limited ANCA vasculitis. These disorders are associated with severe clinical manifestations, frequent relapses and a high cumulative morbidity, and often present with multisystem involvement. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00226/
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http://dx.doi.org/10.3389/fped.2018.00226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107029PMC
August 2018
13 Reads

Alkylating histone deacetylase inhibitors may have therapeutic value in experimental myeloperoxidase-ANCA vasculitis.

Kidney Int 2018 Nov 26;94(5):926-936. Epub 2018 Aug 26.

Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Trinity College Dublin, St. James' Hospital Campus, Dublin, Ireland; Irish Centre for Vascular Biology, Trinity College Dublin, Dublin, Ireland. Electronic address:

Current therapies for treating antineutrophil cytoplasm autoantibody (ANCA)-associated vasculitis include cyclophosphamide and corticosteroids. Unfortunately, these agents are associated with severe adverse effects, despite inducing remission in most patients. Histone deacetylase inhibitors are effective in rodent models of inflammation and act synergistically with many pharmacological agents, including alkylating agents like cyclophosphamide. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183041
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http://dx.doi.org/10.1016/j.kint.2018.05.028DOI Listing
November 2018
16 Reads

[Vasculitides and eosinophilic pulmonary diseases].

Internist (Berl) 2018 09;59(9):898-910

Abt. für Rheumatologie, Immunologie und Rehabilitation, Kantonsspital St. Gallen, St. Gallen, Schweiz.

Eosinophilic granulocytes form peripheral effector cells controlled by Th2 lymphocytes, which cause local cell, tissue, and functional disorders of infiltrated organs via the release of cytotoxic basic proteins and oxygen radicals. Diseases associated with eosinophilia include systemic and organ-related forms. The lungs are involved in eosinophilic granulomatosis with polyangiitis (EGPA, formerly known as Churg-Strauss syndrome), acute and chronic eosinophilic pneumonia, as well as in an organ manifestation in hypereosinophilic syndrome and certain parasitic diseases. Read More

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http://link.springer.com/10.1007/s00108-018-0479-1
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http://dx.doi.org/10.1007/s00108-018-0479-1DOI Listing
September 2018
16 Reads

Mycobacterium Kansasii Infection and Microscopic Polyangiitis: An Unexpected Association.

Cureus 2018 Jun 18;10(6):e2831. Epub 2018 Jun 18.

Medicine, University of Arizona College of Medicine/mihs, Phoenix, USA.

 () is a nontuberculous mycobacterium, which mainly infects the lungs in immunocompromised patients. We present here the case of a 27-year-old immunocompetent patient who developed pulmonary-renal syndrome, manifested with lung cavitation, miliary nodules, and necrotizing glomerulonephritis accompanied by elevated titers of myeloperoxidase antibody. Cultures from bronchoalveolar lavage were positive for , and the patient was treated with an anti-mycobacterial regimen. Read More

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http://dx.doi.org/10.7759/cureus.2831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101464PMC
June 2018
15 Reads

Neutropenia related to an azathioprine metabolic disorder induced by an inosine triphosphate pyrophosphohydrolase (ITPA) gene mutation in a patient with PR3-ANCA-positive microscopic polyangiitis
.

Clin Nephrol 2018 Nov;90(5):363-369

A 68-year-old Japanese man was monitored for chronic kidney disease (CKD), with unknown primary disease starting in 2014. His serum creatinine (sCr) was stable at ~ 2.5 mg/dL for ~ 2 years. Read More

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http://dx.doi.org/10.5414/CN109383DOI Listing
November 2018
13 Reads

Incidence, prevalence, mortality and chronic renal damage of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a 20-year population-based cohort.

Nephrol Dial Transplant 2018 Aug 8. Epub 2018 Aug 8.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

Background: True population-based clinical and outcomes data are lacking for anti-neutrophil cytoplasmic autoantibody (ANCA)-associated glomerulonephritis (AAGN). Therefore we aimed to estimate the incidence, prevalence and mortality of AAGN, as well as the relationship between the grade of chronic renal damage at presentation and renal and non-renal outcomes.

Methods: Patients with AAGN were identified among a population-based incident cohort of 57 Olmsted County residents diagnosed with ANCA-associated vasculitis (AAV) in 1996-2015. Read More

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http://dx.doi.org/10.1093/ndt/gfy250DOI Listing
August 2018
3 Reads

C-Reactive Protein to Serum Albumin Ratio Is an Independent Predictor of All-Cause Mortality in Patients with ANCA-Associated Vasculitis.

Yonsei Med J 2018 Sep;59(7):865-871

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Purpose: We investigated whether C-reactive protein (CRP) to serum albumin ratio (CAR) could be an independent predictor of all-cause mortality in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

Materials And Methods: We retrospectively reviewed the medical records of 170 patients with AAV. We collected clinical and laboratory data. Read More

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http://dx.doi.org/10.3349/ymj.2018.59.7.865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082976PMC
September 2018
5 Reads

Characteristics, outcome and treatments with cranial pachymeningitis: A multicenter French retrospective study of 60 patients.

Medicine (Baltimore) 2018 07;97(30):e11413

AP-HP, Hôpital Saint Antoine, Service de Médecine Interne et Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris.

The aim of this study was to determine the characteristics, treatment, and outcome according to each etiology of pachymeningitis.We conducted a retrospective multicenter French nationwide study between 2000 and 2016 to describe the characteristics, outcome, and treatment of pachymeningitis.We included 60 patients (median age 55. Read More

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http://dx.doi.org/10.1097/MD.0000000000011413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078725PMC
July 2018
7 Reads

Microscopic polyangiitis and interstitial lung disease.

Med Clin (Barc) 2018 Jul 9. Epub 2018 Jul 9.

Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, España.

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http://dx.doi.org/10.1016/j.medcli.2018.05.027DOI Listing
July 2018
3 Reads

2017 Clinical practice guidelines of the Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis for the management of ANCA-associated vasculitis.

Mod Rheumatol 2018 Sep 10:1-11. Epub 2018 Sep 10.

p Division of Nephrology and Rheumatology, First Department of Internal Medicine , Kyorin University School of Medicine , Tokyo , Japan.

Objective: The Japan Research Committee for Intractable Vasculitis has fully revised the clinical practice guidelines (CPG) for the management of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) to improve and standardize the medical treatment of the disease in Japan.

Methods: The previous CPG was published in a classical review style in Japanese in 2011 and 2014. We adopted the Grading of Recommendations Assessment, Development and Evaluation system for this revision, and various stakeholders, including patients, participated in it. Read More

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http://dx.doi.org/10.1080/14397595.2018.1500437DOI Listing
September 2018
11 Reads

Systematic review and meta-analysis for 2017 clinical practice guidelines of the Japan research committee of the ministry of health, labour, and welfare for intractable vasculitis for the management of ANCA-associated vasculitis.

Mod Rheumatol 2019 Jan 25;29(1):119-129. Epub 2018 Sep 25.

k Department of Nephrology and Rheumatology, First Department of Internal Medicine , Kyorin University School of Medicine , Tokyo , Japan.

Objectives: To provide evidence for the revision of clinical practice guideline (CPG) for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by the Japan Research Committee for Intractable Vasculitis.

Methods: PubMed, CENTRAL, and the Japan Medical Abstracts Society were searched for articles published between January 1994 and January 2015 to conduct systematic review (SR), and the quality of evidence was assessed with GRADE approach.

Results: Nine randomized controlled trials (RCTs) and two non-RCTs were adopted for remission induction therapy, three RCTs and two non-RCTs for plasma exchange, and five RCTs and one non-RCT for remission maintenance therapy. Read More

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http://dx.doi.org/10.1080/14397595.2018.1500111DOI Listing
January 2019
8 Reads