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    241 results match your criteria Microcystic Adnexal Carcinoma

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    Image Gallery: Microcystic adnexal carcinoma (syringomatous carcinoma and sclerosing sweat duct carcinoma) as an extensive sclerotic erythematous plaque with telangiectasia over the face.
    Br J Dermatol 2017 Jun;176(6):e122
    Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

    Update on Malignant Sweat Gland Tumors.
    Surg Pathol Clin 2017 Jun 27;10(2):383-397. Epub 2017 Mar 27.
    Department of Pathology, Western General Hospital, Alexander Donald Building, 1st Floor, Crewe Road, Edinburgh EH4 2XU, UK. Electronic address:
    Malignant sweat gland tumors are rare cutaneous neoplasms, traditionally separated according to their behavior into low- and high-grade malignant. There is significant morphologic overlap, and outright malignant tumors may show relatively bland histologic features. They may, therefore, be mistaken easily for benign neoplasms. Read More

    Adnexal Carcinomas Treated With Mohs Micrographic Surgery: A Comprehensive Review.
    Dermatol Surg 2017 Apr 28. Epub 2017 Apr 28.
    Surgical Dermatology Group, Birmingham, Alabama.
    Background: Adnexal carcinomas (ACs) are rare cutaneous malignancies of sweat gland or pilosebaceous origin. Optimal treatment and metastatic potential of AC are poorly defined. Mohs micrographic surgery (MMS) has been increasingly used to treat AC. Read More

    An Aggressive Microcystic Adnexal Carcinoma Infiltrating the Sternum.
    J Drugs Dermatol 2017 Feb;16(2):180-181
    Microcystic adnexal carcinoma is a rare cutaneous tumor that is often misdiagnosed and has the potential to be aggressive. Mohs surgery is the treatment of choice to prevent recurrences. We present a case of a large recurrent microcystic adnexal carcinoma on the sternum, initially diagnosed as a basal cell carcinoma. Read More

    Retrospective study of rare cutaneous malignant adnexal tumors of the head and neck in a tertiary care cancer hospital: a case series.
    J Med Case Rep 2017 Mar 12;11(1):67. Epub 2017 Mar 12.
    Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Centre, 7-A, Block-R3, Johar Town, Lahore, Pakistan.
    Background: Adnexal tumors of the skin are a large and diverse group of benign and malignant neoplasms, which exhibit morphological differentiation toward one of the different types of adnexal epithelium present in normal skin and they pose a diagnostic challenge. The purpose of this study is to share our experience with these rare but aggressive tumors at a tertiary care cancer hospital in a developing country. A retrospective review of 11 patients diagnosed with rare adnexal tumors and their variants from January 2005 to December 2014, treated either surgically or non-surgically, was performed to describe the clinicopathological characteristics and outcome of the disease. Read More

    Georgian Med News 2016 Dec(261):12-14
    Academic Teaching Hospital Dresden-Friedrichstadt, Department of Dermatology and Allergology; Institute of Pathology "Georg Schmorl"; Dresden, Germany.
    Microcystic adnexal carcinoma is a rare malignant sweat gland tumor. We present the case report of a 63 year old male patient who developed this malignancy on the scalp, which is an uncommon site. The tumor has been removed by delayed MOHS technique with no relapse. Read More

    Angiotropic syringomatous carcinoma.
    J Cutan Pathol 2017 Apr 7;44(4):397-400. Epub 2017 Feb 7.
    Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.
    Syringomatous carcinoma (SC) is a slow-growing malignant skin tumor that usually affects the face or scalp. An 83-year-old female developed SC on the sole, a rare location. Histopathologically, numerous ducts with few keratinizing cysts were seen in the upper dermis, and cords, strands and nests with sclerotic stroma were seen in the deep dermis and subcutis. Read More

    Microcystic adnexal carcinoma (MAC)-like squamous cell carcinoma as a differential diagnosis to Bell´s palsy: review of guidelines for refractory facial nerve palsy.
    J Otolaryngol Head Neck Surg 2017 Jan 5;46(1). Epub 2017 Jan 5.
    Department of Otolaryngology, Friedrich-Alexander University Erlangen-Nürnberg, Waldstrasse 1, Erlangen, 91054, Germany.
    Background: Bell´s palsy is the most common cause of facial paralysis worldwide and the most common disorder of the cranial nerves. It is a diagnosis of exclusion, accounting for 60-75% of all acquired peripheral facial nerve palsies. Our case shows the first case of a microcystic adnexal carcinoma-like squamous cell carcinoma as a cause of facial nerve palsy. Read More

    Evidence-Based Medicine: Cutaneous Facial Malignancies: Nonmelanoma Skin Cancer.
    Plast Reconstr Surg 2017 Jan;139(1):181e-190e
    New York, N.Y. From the Dermatology Service and the Plastic Surgery Service, Memorial Sloan Kettering Cancer Center.
    Learning Objectives: After studying this article, the participant should be able to: 1. Identify clinical features of nonmelanoma skin cancer; 2. Distinguish low-risk versus high-risk basal cell carcinoma and squamous cell carcinoma; 3. Read More

    Incidence and Clinical Features of Rare Cutaneous Malignancies in Olmsted County, Minnesota, 2000 to 2010.
    Dermatol Surg 2017 Jan;43(1):116-124
    *Department of Dermatology, Mayo Clinic, Rochester, Minnesota;†Division of Biomedical Statistics and Informatics, Mayo Clinic Rochester, Minnesota;‡Division of Dermatologic Surgery, Mayo Clinic, Rochester, Minnesota.
    Background: The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data.

    Objective: To determine the incidence of several rare nonmelanoma skin cancers. Read More

    Microcystic Adnexal Carcinoma of the Nasal Tip Treated With Surgical Excision and Rotational Forehead Skin Flap.
    J Craniofac Surg 2016 Nov;27(8):e756-e758
    *Department of Otorhinolaryngology†Department of Pathology‡Department of Plastic Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
    Microcystic adnexal carcinoma (MAC) is a rare malignant cutaneous adenocarcinoma that typically occurs in the head and neck, particularly at the central face. There are only slightly more than 300 patients reported worldwide, and most patients occur in Caucasians. A 72-year-old man was referred to our hospital for definitive treatment of known MAC from previous biopsy. Read More

    Mohs micrographic surgery of rare cutaneous tumours.
    J Eur Acad Dermatol Venereol 2016 Dec 15. Epub 2016 Dec 15.
    Department of Dermatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.
    Background: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumours are poorly defined.

    Objective: To investigate the recurrence rate after MMS for rare cutaneous tumours at a university centre.

    Methods & Materials: Retrospective review of all rare cutaneous tumours treated with MMS at a large university centre between January 2008 and December 2012. Read More

    Histopathologic pitfalls of Mohs micrographic surgery and a review of tumor histology.
    Wien Med Wochenschr 2016 Nov 10. Epub 2016 Nov 10.
    Centro Studi per la Ricerca Multidisciplinare e Rigenerativa, Università Degli Studi "G. Marconi", Rome, Italy.
    Mohs micrographic surgery is a specialized subset of staged surgical excisions with each subsequent stage being driven largely by the histologic findings of the previous stage. Therefore, it is imperative that histologic analysis is performed in an accurate manner. Frozen section and tissue flattening is a crucial step in Mohs surgery. Read More

    Sclerosing Microcystic Adenocarcinoma of the Head and Neck Mucosa: A Neoplasm Closely Resembling Microcystic Adnexal Carcinoma.
    Head Neck Pathol 2016 Dec 27;10(4):501-508. Epub 2016 May 27.
    Department of Pathology, University of Virginia, Charlottesville, VA, USA.
    Microcystic adnexal carcinoma (MAC) occurs predominantly in the centrofacial skin and has been only rarely reported in mucosal surfaces. We here present a 5 case series of tumors closely resembling MAC occurring in the mucosal surfaces of the head and neck, which we have termed sclerosing microcystic adenocarcinomas. These tumors showed a predilection for women (4:1) with an average patient age of 52. Read More

    Primary Cutaneous Mammary Analog Secretory Carcinoma With ETV6-NTRK3 Translocation.
    Am J Dermatopathol 2016 Nov;38(11):842-845
    Departments of *Dermatology, and †Pathology, Northwestern University, Chicago, IL; and ‡Forefront Dermatology, Manitowoc, WI.
    Mammary analog secretory carcinoma (MASC) is a recently described tumor of the salivary glands named for its morphological and molecular similarity to secretory carcinoma of the breast. Many primary carcinomas arising from the adnexal glands also share similar morphology to those arising from the breast. Brandt et al first described primary cutaneous MASC in 2009 and since then only 2 other cases have been reported. Read More

    Microcystic Adnexal Carcinoma of the Nasal Tip Treated With Surgical Excision and Rotational Forehead Skin Flap.
    J Craniofac Surg 2016 Oct 14. Epub 2016 Oct 14.
    *Department of Otorhinolaryngology †Department of Pathology ‡Department of Plastic Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
    Microcystic adnexal carcinoma (MAC) is a rare malignant cutaneous adenocarcinoma that typically occurs in the head and neck, particularly at the central face. There are only slightly more than 300 patients reported worldwide, and most patients occur in Caucasians. A 72-year-old man was referred to our hospital for definitive treatment of known MAC from previous biopsy. Read More

    Microcystic adnexal carcinoma in a non-Caucasian patient: A case report and review of the literature.
    Oncol Lett 2016 Apr 17;11(4):2471-2474. Epub 2016 Feb 17.
    Department of Oral and Maxillofacial Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
    Microcystic adnexal carcinoma (MAC) is extremely rare among Asians, with the majority of cases presenting in Caucasian individuals. The current study describes the case of a 38-year-old Chinese woman who presented with a 10 year history of a mass in the upper lip. A biopsy resulted in a diagnosis of MAC. Read More

    Underutilization of Mohs Micrographic Surgery for Less Common Cutaneous Malignancies in the United States.
    Dermatol Surg 2016 May;42(5):653-62
    *Department of Medicine, Section of Dermatology, West Virginia University, Morgantown, West Virginia; †University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; ‡Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; §Department of Epidemiology, Epidemiology Data Center, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania.
    Background: Consensus guidelines have defined select less common skin cancers appropriate for Mohs micrographic surgery (MMS), as these tumors are characterized by asymmetric growth patterns that challenge conventional surgical extirpation of disease.

    Objective: The authors aimed to define surgical patterns of care and to identify factors affecting treatment selection in the United States.

    Materials And Methods: Retrospective cohort analysis of nonmetastatic nonmelanoma skin cancers deemed appropriate for MMS by American Academy of Dermatology/American College of Mohs Surgery/American Society for Dermatologic Surgery Association/American Society for Mohs Surgery appropriate use criteria from the National Cancer Data Base from 1998 to 2012. Read More

    Morpheaform Basal Cell Carcinomas With Areas of Predominantly Single-Cell Pattern of Infiltration: Diagnostic Utility of p63 and Cytokeratin.
    Am J Dermatopathol 2016 Oct;38(10):744-50
    Departments of *Pathology and †Dermatology, University of Michigan Health System, Ann Arbor MI; ‡Michigan Center for Translational Pathology, University of Michigan Health System, Ann Arbor MI; and §Department of Urology, Vattikutti Urology Institute, Henry Ford Health System, Detroit, MI.
    Background: Morpheaform basal cell carcinoma (BCC) is a variant of BCC characterized by narrow strands and nests of basaloid cells with dense sclerotic stroma. The histologic extent often exceeds the clinical impression, leading to high recurrence rates after standard excision. The authors encountered a case with single-cell invasion distant from the main tumor. Read More

    Epidemiology and Prognosis of Primary Periocular Sweat Gland Carcinomas.
    Ophthal Plast Reconstr Surg 2017 Mar/Apr;33(2):101-105
    *Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa; †Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, and ‡Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, U.S.A.
    Purpose: To characterize the clinical presentation, management, and outcomes of patients with sweat gland carcinoma of the periocular region. To review the pathologic classification scheme, compare the clinical behavior between subtypes, and discuss treatment recommendations for periocular sweat gland carcinomas.

    Methods: Retrospective study from 2 tertiary centers, which are part of the American Society of Ophthalmic Plastic and Reconstructive Surgery Oncology Database. Read More

    Infundibulocystic Structures and Prominent Squamous Metaplasia in Sebaceoma-A Rare Feature. A Clinicopathologic Study of 10 Cases.
    Am J Dermatopathol 2016 Sep;38(9):678-82
    *Labor für Dermatohistologie und Oralpathologie, München, Germany; †Dermatopathologie Friedrichshafen, Friedrichshafen, Germany; ‡Miraca Life Science Laboratory, Irving, TX; §Department of Clinical Pathology, University of Zagreb, Zagreb, Croatia; ¶Department of Pathology, Charles University in Prague, Faculty of Medicine in Pilsen, Pilsen, Czech Republic; ‖Bioptical Laboratory, Pilsen, Czech Republic; and **Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.
    The authors describe 10 cases of sebaceoma that manifested prominent infundibulocystic structures in all cases and, additionally, conspicuous squamous metaplasia in 6 neoplasms. All tumors occurred on the scalp or the face (2 cases lacked clinical information) and presented as a solitary lesion, measuring from 5 to 20 mm. The patients' age ranged from 22 to 89 years. Read More

    Microcystic Adnexal Carcinoma of the scalp in an african-american male.
    Dermatol Online J 2016 Sep 15;22(9). Epub 2016 Sep 15.
    University of Texas Southwestern Medical Center.
    Microcystic adnexal carcinoma (MAC) is a rare adnexal neoplasm that typically presents in Caucasians. We report a rare case of MAC in a 68 year old African American male that presented as a large asymptomatic scalp mass. The clinical and histologic features of MAC are discussed. Read More

    Misdiagnosed microcystic adnexal carcinoma on the lateral forehead and challenges in reconstruction of a large and bone-deep defect.
    J Dtsch Dermatol Ges 2016 Jan;14(1):86-90
    Department of Dermatology, Venereology and Allergology, Academic Teaching Department of Medical University Innsbruck, Central Teaching Hospital Bolzano/Bozen, Italy.
    Background: Microcystic adnexal carcinoma (MAC) is a rare cutaneous malignancy characterized by aggressive local infiltration, including a high propensity for perineural invasion. Histologically it can be easily confused with benign adnexal tumors, which often leads to inappropriate initial treatment. As a consequence delayed surgical excision often requires removal of large cutaneous masses which can be followed by challenges in reconstruction. Read More

    Microcystic Adnexal Carcinoma Detected by Reflectance Confocal Microscopy.
    Dermatol Surg 2016 Jan;42(1):126-7
    Department of Dermatology, Rutgers Robert Wood Johnson Medical School, Somerset, New Jersey Department of Dermatology, Weill Cornell Medical College, New York, New York Department of Dermatology, Rutgers Robert Wood Johnson Medical School, Somerset, New Jersey.

    Desmoplastic trichoepithelioma: A clinicopathological study of three cases and a review of the literature.
    Oncol Lett 2015 Oct 21;10(4):2468-2476. Epub 2015 Jul 21.
    Department of Dermatology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China.
    Desmoplastic trichoepithelioma (DTE) is a rare benign adnexal tumor with the characteristic features of asymptomatic, solitary, annular, indurated and centrally depressed papules or plaques, most commonly occurring in younger individuals on the face. Microscopically and clinically, DTE may be difficult to distinguish from other cutaneous adnexal neoplasms, particularly syringoma, cutaneous metastatic breast cancer, morpheaform basal cell carcinoma and microcystic adnexal carcinoma. The present study reports three cases of DTE. Read More

    Treatment of nasal microcystic adnexal carcinoma with an expanded rotational forehead skin flap: A case report and review of the literature.
    Exp Ther Med 2015 Sep 3;10(3):1202-1206. Epub 2015 Jul 3.
    Department of Plastic Surgery, The 117 Hospital of People's Liberation Army, Hangzhou, Zhejiang 310013, P.R. China.
    Microcystic adnexal carcinoma (MAC) is a rare and locally aggressive adenocarcinoma with low-grade malignancy. The present study describes the first reported case and treatment of a Chinese male with a MAC located on the nasal dorsum and nosewing. A 44-year-old man presented with a nasal deformity caused by local repeated infections following an accidental injury to the nose 20 years previously. Read More

    Distinctive immunostaining of claudin-4 in spiradenomas.
    Ann Diagn Pathol 2016 Feb 28;20:44-7. Epub 2015 Oct 28.
    Department of Pathology, Gülhane Military Medical Academy and School of Medicine, Ankara, Turkey. Electronic address:
    The intercellular bridges are essential structures in maintaining the histologic organization of the epithelium, while providing a very efficient way to exchange molecules between cells and transduction of the cell-to-cell and matrix-to-cell signals. Derangement in those important structures' physical integrity and/or function, which can be assessed by the presence or absence of several intercellular bridge proteins including claudin-4, E-cadherin, and β-catenin, was found to be related to several phenomena in the path to the neoplastic transformation. However, these proteins have not been studied in the wide variety of the skin neoplasms, in detail. Read More

    GATA3 Expression in Normal Skin and in Benign and Malignant Epidermal and Cutaneous Adnexal Neoplasms.
    Am J Dermatopathol 2015 Dec;37(12):885-91
    Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
    Initial investigations reported GATA3 to be a sensitive and relatively specific marker for mammary and urothelial carcinomas. Recently, GATA3 expression has been described in several other epithelial tumors. However, there has been only limited investigation of GATA3 expression in cutaneous epithelial tumors. Read More

    Longtime undetected microcystic adnexal carcinoma of the scalp: considerations and implications.
    Oral Maxillofac Surg 2016 Jun 10;20(2):211-4. Epub 2015 Nov 10.
    Department of Oral and Maxillofacial Surgery, Klinikum Bremen-Mitte, School of Medicine of the University of Göttingen, Bremen, Germany.
    Background: Microcystic adnexal carcinomas (MACs) are slow-growing and often asymptomatic malignant skin tumours that usually develop on the facial skin and may reach considerable size. We present an uncommon case of MAC arising on the hair-bearing scalp and discuss our experiences and considerations.

    Case Report: A 58-year-old female was admitted with a histopathologically secured diagnosis of MAC of the temporal and occipital regions that had expanded to 10 × 12 cm. Read More

    Treatments for microcystic adnexal carcinoma--A review.
    J Dermatolog Treat 2016 11;27(3):278-84. Epub 2015 Nov 11.
    h Associated Pathologists Chartered , Las Vegas , NV , USA.
    Introduction: Microcystic adnexal carcinoma (MAC) is a rare malignant cutaneous neoplasm presenting as a slow-growing, indurated nodule, papule or plaque. Clinically, the lesion can blend into the surrounding skin, obscuring borders and consequently delaying diagnosis histologically. Surgical and histologic techniques that emphasize examination of all margins may optimize management through early diagnosis and prevention of recurrences. Read More

    Microcystic adnexal carcinoma simulating scarring alopecia.
    An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):36-8
    Universidade Federal de Juiz de Fora, Juiz de Fora, MG, BR.
    The microcystic adnexal carcinoma is a rare, locally aggressive malignant adnexal neoplasm associated with significant morbidity. It is often underdiagnosed due to clinical and histopathological resemblance with other cutaneous neoplasms and/or a combination of lack of familiarity associated with inadequate samples. We report a case with clinical hypothesis of scarring alopecia and histopathological diagnosis of microcystic adnexal carcinoma with favorable outcome in a follow-up of eleven years, after surgical treatment. Read More

    Malignant sweat gland tumours: an update.
    Histopathology 2015 Nov 21;67(5):589-606. Epub 2015 Jul 21.
    Dermatopathology Department, St John's Institute of Dermatology, London, UK.
    Cutaneous adnexal tumours can be a diagnostic challenge for the pathologist. This is particularly true in the case of tumours with sweat gland differentiation, due to a large number of rare entities, a multiplicity of names to designate the same neoplasms and consequent lack of consensus regarding their classification and nomenclature. In the traditional view, sweat gland tumours were divided into eccrine and apocrine. Read More

    Comparative analysis of cytokeratin 15, TDAG51, cytokeratin 20 and androgen receptor in sclerosing adnexal neoplasms and variants of basal cell carcinoma.
    J Cutan Pathol 2015 Nov 3;42(11):824-31. Epub 2015 Jul 3.
    Departments of Dermatology and Pathology, University of California, San Francisco, CA, USA.
    Background: Desmoplastic trichoepithelioma (DTE), morpheaform basal cell carcinoma (BCC) and microcystic adnexal carcinoma (MAC) are sclerosing adnexal neoplasms with overlapping histopathologic features. We compared cytokeratin 15, (CK15), T-cell death-associated gene 51 (TDAG51), cytokeratin 20 (CK20) and androgen receptor (AR) in differentiating these tumors and assessed their expression in BCC subtypes.

    Methods: Fifteen DTE, 15 infundibulocystic BCC, 18 micronodular BCC, 18 morpheaform BCC and 6 MAC were assessed for CK15, TDAG51, CK20 and AR expression. Read More

    Anatomoclinical study of 30 cases of sclerosing sweat duct carcinomas (microcystic adnexal carcinoma, syringomatous carcinoma and squamoid eccrine ductal carcinoma).
    J Eur Acad Dermatol Venereol 2015 Oct 15;29(10):1978-94. Epub 2015 Apr 15.
    Laboratoire d'Histopathologie cutanée, Clinique Dermatologique, Hôpital Civil, Strasbourg, France.
    Background: Microcystic adnexal carcinoma (MAC), syringomatous carcinoma (SC) and "Squamoid eccrine ductal carcinoma" (SEDC) are rare sclerosing adnexal tumours.

    Objective: To understand the histogenesis of these tumours and possible clinical implications.

    Methods: We conducted a retrospective study of 30 cases, 18 MAC, 5 SC and 7 SEDC reviewed and classified by a panel of dermatopathology experts, with immunohistochemical analysis of keratins, including K77, a new keratin specific of eccrine ducts, and PHLDA1 expressed in adnexal structures. Read More

    Microcystic adnexal carcinoma of the cheek-a case report with dermatoscopy and dermatopathology.
    Dermatol Pract Concept 2015 Jan 30;5(1):43-6. Epub 2015 Jan 30.
    Dorevitch Pathology, Heidelberg, Australia.
    We present a case report of a microcystic adnexal carcinoma on the cheek of a 67-year-old man. Clinical, dermatoscopic and dermatopathologic images are presented. A search of the literature has not discovered any previously published dermatoscopy images of microcystic adenexal carcinoma. Read More

    The first reported case of metastatic microcystic adnexal carcinoma in an adolescent.
    Dermatol Surg 2015 Feb;41(2):286-8
    Osteopathic College of Medicine, Touro University Nevada, Henderson, Nevada Department of DermatologyUniversity of Nevada School of Medicine, Las Vegas, Nevada Department of DermatopathologyAssociated Pathologists Chartered, Las Vegas, Nevada Torrey Pines Dermatology, La Jolla, California.

    Microcystic adnexal carcinoma: reconstruction of a large centrofacial defect.
    Plast Reconstr Surg Glob Open 2014 Nov 5;2(11):e254. Epub 2014 Dec 5.
    Division of Plastic Surgery, Department of Surgery, University of Texas Medical Branch, Galveston, Tex.
    Summary: We report a rare case of a large facial microcystic adnexal carcinoma in an elderly patient who underwent several rounds of excision. The patient was left with a large facial defect and remaining positive margins. The decision was made to stop further excision and proceed with reconstructive surgery. Read More

    Microcystic adnexal carcinoma in the axilla of an 18-year-old woman.
    Pediatr Dermatol 2014 Nov-Dec;31(6):e145-8
    Dermatology Department, Walter Reed National Military Medical Center, Bethesda, Maryland.
    Microcystic adnexal carcinoma (MAC) is an uncommon adnexal neoplasm with a predilection for the head and neck. The tumor rarely metastasizes but is locally aggressive and commonly demonstrates perineural invasion. MAC occurs most often in older adults. Read More

    Solid carcinoma revisited: a possible variant of microcystic adnexal carcinoma.
    Am J Dermatopathol 2014 Nov;36(11):925-7
    *Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, and †Department of Medicine, Division of Dermatology, University of Toronto, Toronto, Ontario, Canada; ‡Department of Medicine, LifeLabs, Toronto, Ontario, Canada; and §Department of Medicine (Dermatology), North York General Hospital (Affiliate Hospital of the University of Toronto), Toronto, Ontario, Canada.
    Primary malignant apocrine and eccrine skin neoplasms are rare and their nosology is still evolving. First described in 1997, solid carcinoma is now considered a discrete entity by some, although this remains controversial. Apocrine differentiation was postulated. Read More

    Microcystic adnexal carcinoma: review of a potential diagnostic pitfall and management.
    Cutis 2014 Mar;93(3):162-5
    Largo Medical Center, Medical Education, 2025 Indian Rock Rd, Largo, FL 33774, USA.
    Microcystic adnexal carcinoma (MAC) is an uncommon, locally aggressive cutaneous neoplasm that usually presents as a slow-growing, asymptomatic lesion on the head or neck. Microcystic adnexal carcinoma frequently is misdiagnosed due to its histologic appearance on superficial biopsy specimens mimicking other follicular neoplasms. Herein, we highlight a case in which a slow-growing lesion was initially diagnosed as a trichoadenoma following superficial biopsy; however, after surgical excision the pathology revealed a locally aggressive MAC. Read More

    Correlation of optical coherence tomography and histology in microcystic adnexal carcinoma: a case report.
    Skin Res Technol 2015 Feb 17;21(1):15-7. Epub 2014 Feb 17.
    Department of Dermatology, Venereology and Allergology, Skin Cancer Centre Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany.
    Background/aims: Herein, we report a case of microcystic adnexal carcinoma (MAC), which we correlated and evaluated by optical coherence tomography (OCT) and conventional H&E histology.

    Methods: A commercially available OCT scanner was used for imaging. Several multi-slice images were obtained from the central portion of the lesion. Read More

    Benign subclinical syringomatous proliferations adjacent to a microcystic adnexal carcinoma: a tumor mimic with significant patient implications.
    Am J Dermatopathol 2014 Feb;36(2):174-8
    Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
    Microcystic adnexal carcinoma (MAC) is an uncommon, locally aggressive, malignant cutaneous tumor with pilar and eccrine differentiation. Mohs micrographic surgery is the treatment of choice for this condition, but specific histological findings can complicate MAC removal and leave doubt as to whether the tumor has been completely removed. Here we describe the clinical and pathological characteristics of a case in which a patient with an MAC underwent multiple reexcisions because of the presence of benign subclinical syringomatous proliferations adjacent to the primary lesion. Read More

    Microcystic adnexal carcinoma: successful management of a large scalp lesion.
    J Plast Surg Hand Surg 2014 Apr 23;48(2):158-60. Epub 2013 Aug 23.
    Department of Plastic and Reconstructive Surgery, Bankstown Hospital , New South Wales.
    Microcystic adnexal carcinoma (MAC) is a rare, malignant cutaneous neoplasm. It is important for us to become more aware of it, as it is often misdiagnosed, either clinically or histopathologically. We report a case of an extensive scalp lesion that was successfully treated using a combination of resection and adjuvant radiotherapy. Read More

    The park-bench position in cervico-facial reconstructive surgery: a technical note.
    Acta Otorhinolaryngol Ital 2013 Apr;33(2):129-32
    Department of Maxillofacial Surgery, Fondazione IRCCS Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
    Resection and simultaneous reconstruction with free flaps of wide tumours of the scalp and posterior neck region are difficult to perform through a single surgical approach. In such cases, the park-bench position - a lateral oblique position - could allow simultaneous resection and reconstruction of tumours of the scalp and occipital region without changing the patient's position. In the case described here, this position was used to treat microcystic adnexal carcinoma in a patient who presented with three scalp lesions and a lesion of the right scapular region. Read More

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