1,746 results match your criteria Microcystic Adnexal Carcinoma


Immunoreactivity for Sox10 in Basaloid Neoplasms of The Skin.

Appl Immunohistochem Mol Morphol 2018 Dec 7. Epub 2018 Dec 7.

Section of Dermatopathology, Division of Surgical Pathology-Cytopathology, University of Virginia Medical Center, Charlottesville, VA.

Basaloid tumors of the skin pose a diagnostic challenge to pathologists, because the differential diagnosis is broad, sometimes with subtle differentiating features. We evaluated SOX10 expression in 120 primary cutaneous tumors with epidermal, sweat glandular, neuroendocrine/neuroectodermal, follicular, and sebaceous lineages. Our findings were compared with those of previous studies that evaluated SOX10 in tumors of the skin. Read More

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December 2018

Topical rapamycin (sirolimus) for treatment of cutaneous microcystic lymphatic malformation of the gluteal area.

Eur J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

University Hospital of Tours, Department of Dermatology, Unit of Pediatric Dermatology, Center of Reference of Cutaneous Vascular Malformations (MAGEC), Tours, France.

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December 2018

A case of duodenal hemorrhage due to arteriovenous malformation around a serous cystic neoplasm.

Surg Case Rep 2018 Dec 5;4(1):140. Epub 2018 Dec 5.

Department of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, 1007, Shimo-Nagakubo, Sunto-Nagaizumi, Shizuoka, 4118777, Japan.

Background: No reports have so far described arteriovenous malformation (AVM) in the pancreas caused by a tumor. We herein report a case of pancreatoduodenectomy for a patient who developed duodenal hemorrhage due to AVM developed around serous cystic neoplasm (SCN) of the pancreas.

Case Presentation: A 79-year-old man was referred to our hospital because of anemia (Hb 7. Read More

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December 2018
2 Reads

Tumor growth rate of pancreatic serous cystadenomas: Endosonographic follow-up with volume measurement to predict cyst enlargement.

Pancreatology 2018 Nov 23. Epub 2018 Nov 23.

Gastroclinica WGO Training Center, Tibás, San José, Costa Rica.

Background: Serous cystadenomas are benign lesions of the pancreas. Usually they are diagnosed incidentally on cross-sectional imaging studies. Endosonography is a valuable tool in the diagnosis and follow-up of these cystic lesions. Read More

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November 2018

Symptom Resolution and Volumetric Reduction of Abdominal Lymphatic Malformations With Sclerotherapy.

J Surg Res 2019 Jan 4;233:256-261. Epub 2018 Sep 4.

Division of Pediatric Surgery, Children's Hospital Colorado, Aurora, Colorado; Division of Pediatric Surgery, Children's Hospital Colorado, Vascular Anomalies Center, Aurora, Colorado; Division of Pediatrics, University of Colorado, School of Medicine, Aurora, Colorado.

Background: Lymphatic malformations (LMs) are congenital and arise from errors in vascular embryogenesis. LMs are categorized by cyst size as microcystic, macrocystic, or combined. Abdominal LMs are rare. Read More

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January 2019

Ovarian Sex Cord-Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD.

Authors:
Robert H Young

Arch Pathol Lab Med 2018 Dec;142(12):1459-1484

From the James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Context.—: This year being the 60th anniversary of the publication of the excellent book Endocrine Pathology of the Ovary by John McLean Morris, MD, and Robert E. Scully, MD, the writer reflects on that work and in particular the remarkable contributions of its second author to our knowledge in this area. Read More

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December 2018
1 Read

Malignant Sweat Gland Tumors.

Hematol Oncol Clin North Am 2019 Feb;33(1):53-71

Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA. Electronic address:

Malignant sweat gland neoplasms are a confusing area within dermatopathology, with many entities reported under several designations in the literature. This review describes the key clinical and histopathologic features of select malignant adnexal neoplasms, including porocarcinoma, papillary carcinoma, adenoid cystic carcinoma, cribriform carcinoma, apocrine hidradenocarcinoma, malignant mixed tumor of the skin, syringoid carcinoma, cylindrocarcinoma, spiradenocarcinoma, mucinous carcinoma, polymorphous sweat gland carcinoma, microcystic adnexal carcinoma, secretory carcinoma of the skin, and primary cutaneous signet ring cell carcinoma. For entities with overlapping features, differential diagnoses are discussed. Read More

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February 2019

Image-Guided Percutaneous Bleomycin and Bevacizumab Sclerotherapy of Orbital Lymphatic Malformations in Children.

Cardiovasc Intervent Radiol 2018 Nov 28. Epub 2018 Nov 28.

Department of Ophthalmology, Cairo University Hospitals, Cairo, Egypt.

Purpose: To evaluate the effectiveness and safety of image-guided percutaneous sclerotherapy using bleomycin for macrocystic and bevacizumab (Avastin™) for microcystic orbital lymphatic malformations in children.

Materials And Methods: Between October 2015 and July 2018, we prospectively evaluated 10 pediatric patients who presented clinically and radiologically with lymphatic malformations and were treated with percutaneous sclerotherapy. Patients with venous malformations were excluded. Read More

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November 2018

"Integrated diagnosis" of pilocytic astrocytoma: Molecular diagnostic procedure for an unusual case.

Pathol Int 2018 Nov 12. Epub 2018 Nov 12.

Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, Sapporo, Japan.

A 24 year-old female presented with a mass lesion in the right temporal lobe. This case was difficult to diagnose using histological and immunological methods and therefore molecular analyses were applied to provide a definitive diagnosis. The tumor was well-demarcated, partially cystic, and irregularly-enhanced on gadolinium-enhanced T1-weighted magnetic resonance images. Read More

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November 2018
5 Reads

Expanding the morphological spectrum of ovarian microcystic stromal tumour.

Histopathology 2018 Oct 16. Epub 2018 Oct 16.

Cancer Research Program, Research Institute, McGill University Health Centre, Montreal, QC, Canada.

Aims: To expand the morphological spectrum of ovarian microcystic stromal tumour, a rare neoplasm considered to have a relatively constant morphology with microcysts, solid cellular regions and hyalinised fibrous stroma.

Methods And Results: We report four ovarian neoplasms in patients aged 45, 56, 61 and 71 years with the characteristic immunophenotype of microcystic stromal tumour (diffuse nuclear positivity with beta-catenin, cyclin D1 and WT1; diffuse cytoplasmic positivity with CD10; negative inhibin, calretinin, oestrogen receptor and progesterone receptor). The tumours had variant morphology (diffuse, nested and corded arrangements in three cases, including one with spindle cell elements; nested, corded and tubular in the other). Read More

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October 2018
7 Reads

Mucinous cystadenoma of pancreas with honeycombing appearance: Radiological-Pathological correlation.

Indian J Radiol Imaging 2018 Jul-Sep;28(3):327-329

Department of Radiodiagnosis, Sree Balaji Medical College and Hospital, Chromepet, Chennai, Tamil Nadu, India.

Most mucinous cystadenomas of pancreas are solitary and multilocular with a few large compartments. Serous cystadenomas usually have a polycystic or microcystic (honeycomb) pattern consisting of collection of cysts (usually >6) that range from few millimetres up to 2 cm in size. Here we present a case of mucinous cystadenoma of pancreas showing an unusual appearance of honeycombing (which has not been described so far) using imaging studies such as endoscopic ultrasound and computed tomography with histopathological confirmation of the diagnosis. Read More

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October 2018
1 Read

MELF pattern of myometrial invasion and role in possible endometrial cancer diagnostic pathway: A systematic review of the literature.

Eur J Obstet Gynecol Reprod Biol 2018 Nov 25;230:147-152. Epub 2018 Sep 25.

Department of Gynecological Oncology, Metaxa Memorial Cancer Hospital, Piraeus, Greece.

Microcystic, elongated, fragmented (MELF) pattern of myometrial invasion has been proposed as a prognostic marker in patients with endometrial carcinoma (EC). Its prognostic and predictive effect still remains elusive. The aim of the present study is to accumulate the current knowledge on the role of MELF pattern in the prognosis and survival of patients with EC. Read More

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November 2018
2 Reads

Lumbar intraspinal microcystic/reticular schwannoma: Case report and literature review.

Medicine (Baltimore) 2018 Sep;97(39):e12474

Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Rationale: Microcystic/reticular schwannoma (MRS) is a rare histological variant of schwannoma which was initially described in 2008 with a predilection for the visceral organs. This distinct tumor had been reported to mainly affect gastrointestinal tract, subcutaneous and soft tissue, various glands and head and neck region. However, MRS involving spine is extremely rare. Read More

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September 2018
2 Reads

Microcystic adnexal carcinoma of the skin in atypical site (pubic region): clinical and dermatoscopic features.

G Ital Dermatol Venereol 2018 Sep 20. Epub 2018 Sep 20.

Histopathology Service of the "Celio" Military Hospital of Rome, Rome, Italy.

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September 2018
12 Reads

Microcystic Adenocarcinoma: An Initially Overlooked First Proposal of the Term.

Head Neck Pathol 2018 Sep 21. Epub 2018 Sep 21.

Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama, 350-0283, Japan.

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September 2018

Microcystic adnexal carcinoma of the external auditory canal.

Cutis 2018 08;102(2):E11-E13

Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, and Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Taiwan.

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August 2018
6 Reads

Gastric-type Adenocarcinoma of the Cervix: Tumor With Wide Range of Histologic Appearances.

Adv Anat Pathol 2019 Jan;26(1):1-12

DDL Diagnostic Laboratory, Rijswijk, The Netherlands.

Gastric-type endocervical adenocarcinoma (GAS) is a recently described diagnostic entity originally characterized as a tumor with (1) voluminous cytoplasm that is (2) clear or pale eosinophilic, and (3) cells showing distinct cell borders. Since the initial tumor description there has been accumulating experience that the neoplasm, in addition to classic features, may show a wide spectrum of morphologic appearances. This paper describes and illustrates cases of GAS with focal or diffuse findings that include: densely eosinophilic cytoplasm, foamy cytoplasm, goblet cells, glands with elongated, stratified nuclei, glands with small cuboidal cells, glands with flattened cells, papillary growth, single cell infiltration and infiltration with microcystic elongated and fragmented pattern. Read More

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January 2019
3 Reads

A prospective case-control study comparing optical coherence tomography characteristics in neuromyelitis optica spectrum disorder- optic neuritis and idiopathic optic neuritis.

BMC Ophthalmol 2018 Sep 14;18(1):247. Epub 2018 Sep 14.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, No. 54 Xianlie South Road, Guangzhou, 510060, People's Republic of China.

Background: Neuromyelitis optica spectrum disorder-optic neuritis (NMOSD-ON) can now be distinguished from other types of ON as a specific disease by the Aquaporin-4 antibody (AQP4-Ab) test. NMOSD-ON can cause severe retinal nerve fiber layer (RNFL) damage. The optical coherence tomography (OCT) characteristics between NMOSD- ON and idiopathic optic neuritis (IDON) were seldom studied in Asians. Read More

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September 2018
2 Reads

Meningioma mimicking an intraparenchymal cystic tumor.

Nagoya J Med Sci 2018 Aug;80(3):431-434

Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan.

Meningiomas rarely exhibit cystic lesions with mural nodules, and may be misdiagnosed as intraparenchymal cystic tumors. We herein present a 64-year-old woman with a cystic lesion and enhancing mural nodule in the left temporal lobe accompanied by peritumoral brain edema. Differential diagnoses included low-grade gliomas, hemangioblastoma, and cystic meningioma. Read More

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August 2018
1 Read

Solid carcinoma is a variant of microcystic adnexal carcinoma: A 14-case series.

J Cutan Pathol 2018 Dec 9;45(12):897-904. Epub 2018 Oct 9.

Dermatologist and Dermatopathologist, Friedrichshafen Dermatopathologie, Friedrichshafen, Germany.

Background: Solid carcinoma is a poorly characterized malignant apocrine neoplasm as only 16 cases have been published.

Objective: To characterize its clinical, histopathological, and immunohistochemical features.

Methods: We compiled 14 cases of solid carcinoma and clinical information were updated. Read More

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December 2018
12 Reads
1.560 Impact Factor

PATIENTS WITH EPIRETINAL MEMBRANES DISPLAY RETROGRADE MACULOPATHY AFTER SURGICAL PEELING OF THE INTERNAL LIMITING MEMBRANE.

Retina 2018 Aug 29. Epub 2018 Aug 29.

Department of Ophthalmology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.

Purpose: Intraretinal cystoid spaces are commonly found after surgical peeling of epiretinal membranes. In this study, we explored whether these cysts were associated with ganglion cell loss and thus might be a manifestation of retrograde maculopathy. The latter is a nonvascular edema with a characteristic morphology that is often found in the inner nuclear layer (INL) of patients with optic neuropathy. Read More

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August 2018
4 Reads

Longitudinal bleb morphology in anterior segment OCT after minimally invasive transscleral ab interno Glaucoma Gel Microstent implantation.

Acta Ophthalmol 2018 Aug 29. Epub 2018 Aug 29.

Department of Ophthalmology and Optometry, University Clinic Salzburg, Paracelsus Medical University, Salzburg, Austria.

Purpose: Like the classic trabeculectomy, the minimally invasive, ab interno XEN Glaucoma Gel Microstent (XEN-GGM) creates a filtration bleb in the conjunctiva. The goal of this study was to investigate internal bleb morphology over time with anterior segment optical coherence tomography (AS-OCT) after XEN-GGM implantation.

Methods: In a prospective, single-centre, single-armed cohort study, blebs were characterized using AS-OCT in 78 eyes of 60 patients at day 1, at weeks 1 and 2 and at months 1, 3, 6, 9 and 12 after XEN-GGM implantation in patients with open-angle glaucoma. Read More

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August 2018
1 Read

Unicystic high-grade intraductal carcinoma of the parotid gland: cytological and histological description with clinic-pathologic review of the literature.

APMIS 2018 Sep;126(9):771-776

Laboratory of Pathology, Department of Translational Medicine, UPO School of Medicine, Novara, Italy.

Intraductal carcinoma of the salivary glands is a rare, not well-characterized tumor. We reviewed the literature and report the first case of a high-grade unicystic intraductal carcinoma of the parotid. Formalin-fixed/paraffin-embedded blocks were sectioned and stained for hematoxylin and eosin and immunostains (CAM5. Read More

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September 2018
10 Reads

[Secretory carcinoma of the breast: clinical histopathologic and biological behaviors].

Zhonghua Yi Xue Za Zhi 2018 Aug;98(30):2434-2437

Department of Pathology, First People's Hospital of Lianyungang, Lianyungang 222002, China.

To investigate the clinicopathological and immunohistochemistrical features of secretory carcinoma of the breast (SCB), as well as its diagnosis and prognosis. Five cases of SCB were collected and specimens were fully drawn. Microscopic pathology examinations and immunohistochemistry(SP method)were performed. Read More

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August 2018
10 Reads

A case of microcystic lymphatic malformation successfully treated with topical sirolimus.

Dermatol Ther 2018 09 22;31(5):e12673. Epub 2018 Aug 22.

Gulhane Medical Faculty, Department of Dermatology, University of Health Sciences, Ankara, Turkey.

Microcystic lymphatic malformation (MLM), also known as "lymphangioma circumscriptum," is a lymphatic malformation which may involve the skin and subcutaneous tissues. Progressive growth of lesions may cause pressure to the surrounding organs. Lesions frequently reoccur after treatment with surgery, sclerotherapy, radiotherapy, and laser therapy. Read More

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September 2018
9 Reads

Gene Expression Differences in Pediatric Lymphatic Malformations: Size Really Matters.

Lymphat Res Biol 2018 Aug;16(4):347-352

6 Department Otolaryngology, University of Arkansas for Medical Sciences , Little Rock, Arkansas.

Lymphatic malformations (LMs) are congenital vascular anomalies characterized by dilated and cystic lymphatic channels. They are subdivided into macrocystic and microcystic lesions based upon the predominant size of the cysts involved. However, significant differences in clinical characteristics, treatment outcomes, and prognosis between macrocytic and microcytic disease suggest variation in underlying biologic and genetic influences. Read More

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August 2018
11 Reads

Retinal imaging with optical coherence tomography: a biomarker in multiple sclerosis?

Eye Brain 2018 31;10:47-63. Epub 2018 Jul 31.

Department of Clinical Neurosciences,

Multiple sclerosis (MS) is a progressive neurological disorder characterized by both inflammatory and degenerative components that affect genetically susceptible individuals. Currently, the cause of MS remains unclear, and there is no known cure. Commonly used therapies tend to target inflammatory aspects of MS, but may not halt disease progression, which may be governed by the slow, subclinical accumulation of injury to neuroaxonal structures in the central nervous system (CNS). Read More

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July 2018
8 Reads

Inner Retinal Changes in Primary Open-Angle Glaucoma Revealed Through Adaptive Optics-Optical Coherence Tomography.

J Glaucoma 2018 Nov;27(11):1025-1028

The Ohio State University College of Optometry.

Purpose: To examine the microstructural changes in the inner nuclear layer (INL) and ganglion cell layer (GCL) in a primary open-angle glaucoma (POAG) subject at 2 timepoints, 4 months apart.

Patients And Methods: This case-control study (1 POAG subject and 1 normal control) used the single cell, 3-dimensional volumetric imaging capability of an adaptive optics-optical coherence tomography-scanning laser ophthalmoscopy system to examine the inner retina.

Results: At the area of greatest glaucomatous change in the POAG subject [3-degrees temporal (T), 3-degrees inferior (I), right eye], the GCL was greatly thinned at both timepoints, yet retinal ganglion cell soma remained visible amid a meshwork of capillaries. Read More

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November 2018

[Clinicopathologic and molecular genetic analysis of secretory carcinoma of salivary gland].

Zhonghua Kou Qiang Yi Xue Za Zhi 2018 Aug;53(8):533-538

Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To investigate the clinicopathologic and molecular genetic features of secretory carcinoma of salivary gland (SCSG). Six cases of SCSG were collected from Zhejiang Provincial Peoples Hospital from January 2011 to March 2018. The clinical, histopathological and immunohistochemical features were analyzed and fluorescence in situ hybridization (FISH) was used to detect ETV6 gene rearrangement. Read More

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August 2018
2 Reads

Imaging characteristics of cerebral extraventricular neurocytoma with pathological correlation.

J Neurooncol 2018 Nov 30;140(2):289-296. Epub 2018 Jul 30.

Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.

Purpose: Extraventricular neurocytoma (EVN) is an exceedingly rare tumor. In this study, we sought to characterize the imaging and pathological features of this uncommon tumor.

Methods: Retrospective review of 18 patients (9 male; 9 female) with pathologically confirmed EVN treated at a single center between 2005 and 2017. Read More

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November 2018
8 Reads

Microcystic Adnexal Carcinoma of the Nipple.

Wounds 2018 Jun;30(6):E65-E67

Division of Plastic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN.

Background: Microcystic adnexal carcinoma (MAC) is a rare infiltrative cutaneous tumor, but with its locally aggressive nature, high rate of recurrence, and rare metastatic potential, it is an important clinical entity to consider when faced with a nipple lesion. These tumors are frequently misdiagnosed based on superficial biopsy alone.

Case Report: This case of a 15-year-old girl with MAC of the nipple demonstrates the importance of having a high index of suspicion in order to obtain a diagnosis, to determine the extent of disease, and to achieve adequate resection before reconstruction. Read More

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June 2018
18 Reads

Combined 68Ga-NOTA-PRGD2 and 18F-FDG PET/CT Can Discriminate Uncommon Meningioma Mimicking High-Grade Glioma.

Clin Nucl Med 2018 Sep;43(9):648-654

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD.

Objectives: Uncommon pathological subtypes of meningioma may present with severe peritumoral brain edema and mimic high-grade glioma (HGG). In a prospective cohort study of Ga-NOTA-PRGD2 PET/CT to evaluate glioma, we occasionally observed that a combination of Ga-NOTA-PRGD2 and F-FDG was able to differentiate these 2 lesion types.

Methods: From 2013 to 2016, 21 patients suspected of HGG by MRI were recruited for evaluation using Ga-NOTA-PRGD2 PET/CT. Read More

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September 2018
4 Reads

LINEZOLID-INDUCED MITOCHONDRIAL TOXICITY PRESENTING AS RETINAL NERVE FIBER LAYER MICROCYSTS AND OPTIC AND PERIPHERAL NEUROPATHY IN A PATIENT WITH CHRONIC GRANULOMATOUS DISEASE.

Retin Cases Brief Rep 2018 Jul 25. Epub 2018 Jul 25.

Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: To report a case with unique changes in the retinal nerve fiber layer observed on optical coherence tomography in a 22-year-old patient on chronic linezolid therapy for recurrent pyogenic liver abscesses with underlying chronic granulomatous disease.

Methods: History and clinical examination, laboratory evaluation, fluorescein angiography, and optical coherence tomography.

Results: The patient presented with best-corrected visual acuity of 20/200 in the right eye and 20/125 in the left eye. Read More

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Ovarian microcystic stromal tumor: Radiologic-pathologic correlation.

Gynecol Oncol Rep 2018 Aug 8;25:11-14. Epub 2018 May 8.

Department of Gynecologic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Ovarian microcystic stromal tumor (MST) is characterized by microcysts, solid cellular regions with lobulated growth, and collagenous or fibrous stroma forming hyaline plaques. While several reports have evaluated the unique pathologic and immunohistochemical profile of these tumors, there has been limited description of the radiologic findings of ovarian microcystic stromal tumor in the literature. We present a case of a 66 year old female who presented for evaluation of a new cystic pelvic mass found to have ovarian microcystic stromal tumor. Read More

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August 2018
8 Reads

Tumor-Associated T-Lymphocytes and Macrophages are Decreased in Endometrioid Endometrial Carcinoma with MELF-Pattern Stromal Changes.

Cancer Microenviron 2018 Jul 14. Epub 2018 Jul 14.

Department of Pathology, Gomel State Medical University, Lange str. 5, Gomel, 246029, Republic of Belarus.

Microcystic, elongated, fragmented (MELF)-pattern is an unusual morphology of myometrial invasive front in endometrioid endometrial carcinoma (EA). The aim of the study was to investigate potential correlation between MELF-pattern and peritumoral inflammatory immune response. A total of 96 out of 368 patients were included in this study. Read More

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July 2018
14 Reads

An Unusual Morphological Presentation of Cutaneous Squamous Cell Carcinoma Mimicking Microcystic Adnexal Carcinoma: A Diagnostic Pitfall.

Dermatopathology (Basel) 2018 Apr-Jun;5(2):64-68. Epub 2018 May 23.

Department of Dermatology and Venereology, University Hospital of Geneva, Geneva, Switzerland.

Cutaneous squamous cell carcinoma (SCC) exhibiting microcystic adnexal carcinoma-like differentiation is an extremely rare tumor that shows both squamous and ductal differentiation. This tumor is often misdiagnosed clinically and histologically and is confused with other malignant and benign cutaneous neoplasms. It usually occurs in middle-aged to older adults. Read More

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May 2018
13 Reads

Sclerosing Microcystic Adenocarcinoma: Report of a Rare Case and Review of Literature.

Head Neck Pathol 2018 Jul 10. Epub 2018 Jul 10.

Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53792, USA.

Sclerosing microcystic adenocarcinoma is an exceedingly rare entity occurring in the mucosal surfaces of the head and neck that closely resembles cutaneous microcystic adnexal carcinoma. Here, we report a case of sclerosing microcystic adenocarcinoma that presented as a vague mass at the floor of the mouth in a 55-year-old woman. The pathology features and the diagnostic challenges, especially in the biopsy and margin evaluation are discussed here. Read More

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July 2018
12 Reads

PIK3CA mutations are specifically localized to lymphatic endothelial cells of lymphatic malformations.

PLoS One 2018 9;13(7):e0200343. Epub 2018 Jul 9.

Institute of Anatomy and Cell Biology, University Medical School Göttingen, UMG, Göttingen, Germany.

Lymphatic malformations (LM) are characterized by the overgrowth of lymphatic vessels during pre- and postnatal development. Macrocystic, microcystic and combined forms of LM are known. The cysts are lined by lymphatic endothelial cells (LECs). Read More

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July 2018
15 Reads

[Eutrophication and Characteristics of Cyanobacteria Bloom in the Summer in Guishi Reservoir].

Huan Jing Ke Xue 2017 Oct;38(10):4141-4150

South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510655, China.

Large-scale cyanobacteria bloom occurred in the summer of 2014 in the Guishi Reservoir that is an important drinking water source for Hezhou City. The dynamic change regularity, external pollution sources, and the phytoplankton community characteristics during the bloom were investigated to evaluate the eutrophication in the reservoir and to present effective prevention and control measures. The results showed that nitrogen and phosphorus concentrations increased year by year; water quality on some sites has been out of class Ⅱ of national water quality standards; and the main pollution source was the agricultural non-point sources. Read More

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October 2017
2 Reads

Cutaneous microcystic/reticular schwannoma: case report and literature review of an exceedingly rare entity with an unusual presentation.

Rom J Morphol Embryol 2018 ;59(1):303-309

Department of Anesthesiology and Intensive Care, University Emergency Hospital, Bucharest, Romania; Department of Plastic Surgery, University Emergency Hospital, Bucharest, Romania;

Conventional schwannoma represents a benign peripheral nerve sheath tumor derived from Schwann cells, which usually arises in the fourth or fifth decade of life, in the subcutaneous tissue of the distal extremities, or in the head and neck region of adult patients, with no gender predilection. In addition to the classic type, at least 11 different histopathological subtypes have been described and unawareness of these uncommon histopathological entities may lead to diagnostic pitfalls and risk of mistreatment. Recently described in the scientific literature, microcystic/reticular schwannoma is still relatively unknown to both surgeons and pathologists. Read More

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October 2018
2 Reads

Clinicopathological significance and prognostic value of myoinvasive patterns in endometrial endometrioid carcinoma.

Rom J Morphol Embryol 2018 ;59(1):13-22

Department of Morphofunctional Sciences I - Histology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania;

Endometrioid endometrial carcinoma has an overall good prognosis. However, variable five-year survival rates (92%-42%) have been reported in FIGO stage I, suggesting the involvement of other factors related to tumor biological behavior. These may be related to the role played by epithelial-mesenchymal transition (EMT) and cancer stem cells in endometrial carcinogenesis. Read More

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October 2018
6 Reads

Cytogenetic and immunohistochemical study of 42 pigmented microcystic chromophobe renal cell carcinoma (PMChRCC).

Virchows Arch 2018 Jun 21. Epub 2018 Jun 21.

Universidad de Navarra, Calle Irunlarrea no. 1, 31008, Pamplona, Spain.

Pigmented microcystic chromophobe renal cell carcinoma (PMChRCC) is a recently described morphologic variant of ChRCC. We have identified 42 cases in 40 patients in the last 24 years. We have investigated their clinical, morphologic, immunohistochemical, and cytogenetic features. Read More

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June 2018
12 Reads

Microcystic macular oedema in optic neuropathy: case series and literature review.

Clin Exp Ophthalmol 2018 May 25. Epub 2018 May 25.

Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.

Cavitations in the inner nuclear layer associated with severe optic atrophy and loss of retinal ganglion cells have clinically been termed microcystic macular oedema (MME). We describe a case series of MME in patients of all ages but predominantly younger patients with a wide range of optic atrophies ranging from acute onset optic disc drusen associated ischemic optic neuropathy to slowly progressive disease as glaucoma. There were no physical distinctions between MME in different causes of optic atrophy suggesting a common causative mechanism. Read More

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May 2018
2 Reads

[Acquired cystic kidney disease-associated renal cell carcinoma: a clinicopathologic study of three cases].

Zhonghua Bing Li Xue Za Zhi 2018 May;47(5):366-371

Department of Pathology, 401 Hospital of PLA, Qingdao 266071, China.

To study the clinicopathologic, immunohistochemical (IHC), histogenetic and prognostic features of acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC). Three cases of ACKD-RCC, including two from 401 Hospital of PLA and one from the Affiliated Hospital of Qingdao University were studied by clinical, histological and IHC analysis with review of relevant literature. All the three patients were male, ranging from 46 to 78 years old. Read More

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May 2018
2 Reads

Dysembryoplastic neuroepithelial tumor-like pilocytic astrocytoma: A case report.

Medicine (Baltimore) 2018 May;97(20):e10755

Department of Pathology, Southern District of Anhui Provincial Hospital, Hefei, Anhui, China.

Rationale: Pilocytic astrocytoma (PA) typically shows biphasic pattern with a mixture of loose microcystic and compact regions, in which it is not uncommon to see heterogeneous morphology. However, there has not been reported in the literatures of the PA type that shows similarity to dysembryoplastic neuroepithelial tumor (DNT) in both histological morphology and immunophenotype.

Patient Concerns: The present study described a case of PA affecting the right temporal-occipital lobe in a 22-year-old male patient. Read More

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May 2018
5.720 Impact Factor

Cutaneous Squamous Cell Carcinoma With Sclerosing Features: An Uncommon and Potentially Aggressive Variant.

Am J Dermatopathol 2018 Aug;40(8):575-579

Department of Pathology, Section of Dermatopathology, University of Virginia Health System, Charlottesville, VA.

Sclerosing squamous cell carcinoma (SCC), also known as "desmoplastic" SCC, is a rare subtype of cutaneous malignancy. This variant is clinically significant because it is associated with an increased risk of local recurrence and metastasis. We herein present 16 examples of sclerotic SCC of the skin in 8 men and 3 women, with a median age of 66 years. Read More

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August 2018
3 Reads

Serous Pancreatic Cystadenoma with Compression of Wirsung's Duct.

J Gastrointest Surg 2018 May 7. Epub 2018 May 7.

Department of Integrated Medicine, Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.

Serous cystadenoma of the pancreas is a common cystic neoplasm typically of benign evolution that rarely communicates with the pancreatic ductal system. We present several images originating from two cases of serous cystadenoma of the pancreas which led to compression and dilatation of Wirsung's duct. These cases suggest that when the diagnosis of pancreatic microcystic lesion is detected, associated, or not associated with a central fibrous scar and a low carcinoembryonic antigen level in the aspirated fluid, the presence of dilatation of Wirsung's duct does not exclude the diagnosis of serous pancreatic cystadenoma. Read More

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Characteristic features and proposed classification in 69 cases of intracranial microcystic meningiomas.

Neurosurg Rev 2018 May 2. Epub 2018 May 2.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 TiantanXili, Dongcheng District, Beijing, 100050, China.

Microcystic meningioma (MM) is a rare subtype of intracranial meningiomas, with clinical and radiologic features not well characterized in the literature. Based on our experience, we propose a classification system of intracranial MMs. We reviewed the medical records, radiographic studies, and operative notes of a group of consecutive patients with intracranial MM. Read More

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May 2018
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Salivary Secretory Carcinoma With a Novel ETV6-MET Fusion: Expanding the Molecular Spectrum of a Recently Described Entity.

Am J Surg Pathol 2018 Aug;42(8):1121-1126

Oncology.

Secretory carcinoma of the salivary glands, also known as mammary analogue secretory carcinoma, is a recently described tumor characterized by generally indolent clinical behavior and recurrent ETV6-NTRK3 fusions. However, a small subset of recent cases with high-grade histology, aggressive behavior, or alternate molecular findings are expanding the spectrum of this entity. In this case, a 59-year-old female presented with an infiltrative submandibular gland tumor that was originally classified as a high-grade acinic cell carcinoma, papillary-cystic variant. Read More

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August 2018
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