267 results match your criteria Microcystic Adnexal Carcinoma


Collision tumor of microcystic adnexal carcinoma and squamous cell carcinoma discovered on Mohs sections.

JAAD Case Rep 2020 Jun 18;6(6):479-481. Epub 2020 Apr 18.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1016/j.jdcr.2020.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256221PMC

Multifocal Recurrent Microcystic Adnexal Carcinoma.

J Craniofac Surg 2020 May 8. Epub 2020 May 8.

Division of Otolaryngology, Department of Surgery, The George Washington University, Washington, DC.

Microcystic adnexal carcinoma (MAC) is a rare and locally aggressive neoplasm with preponderance for local recurrence but rarely nodal or distant metastasis. A 38-year-old male was referred to our clinic for definitive treatment of known recurrent and concern for multifocal MAC from previous biopsy. The patient was treated with modified Mohs and reconstruction with an anterolateral thigh (ALT) free flap for tissue coverage. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006502DOI Listing

Morphologically High-Grade Microcystic Adnexal Carcinoma: A report of two cases.

Histopathology 2020 May 2. Epub 2020 May 2.

Department of Dermatopathology, St John's Institute of Dermatology, St Thomas' Hospital, London, England.

Aims: Microcystic adnexal carcinoma is a distinctive sweat duct carcinoma of low-grade malignant potential with risk for locally destructive growth and local recurrence. Distant metastases and disease related mortality is exceptional. The histological hallmarks of these tumours are the diffusely infiltrative growth within dermis, the frequent invasion of subcutaneous structures, the presence of perineurial invasion and the bland cytological features. Read More

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http://dx.doi.org/10.1111/his.14130DOI Listing

Microcystic Adnexal Carcinoma of the Face Treated With Definitive Chemoradiation: A Case Report and Review of the Literature.

Adv Radiat Oncol 2020 Mar-Apr;5(2):301-310. Epub 2019 Dec 13.

Department of Radiation Oncology Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.adro.2019.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136639PMC
December 2019

Dermoscopic pitfall: Microcystic adnexal carcinoma mimicking basal cell carcinoma.

Indian J Dermatol Venereol Leprol 2020 Mar-Apr;86(2):202-205

Department of Dermatology and Venereologym, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_209_19DOI Listing
January 2020

Microcystic adnexal carcinoma: report of rare cases.

Biosci Rep 2020 Jan;40(1)

Department of Psychiatry, First Clinical Medical College/First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.

Microcystic adnexal carcinoma (MAC) is a rare, locally aggressive malignant neoplasm that derives from cutaneous eccrine/apocrine glands. MAC is classified as an eccrine/apocrine gland tumor and usually occurs in the skin. Here, we characterized and compared two cases of MAC. Read More

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http://dx.doi.org/10.1042/BSR20191557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974419PMC
January 2020
2.637 Impact Factor

Next-generation sequencing implicates oncogenic roles for p53 and JAK/STAT signaling in microcystic adnexal carcinomas.

Mod Pathol 2019 Dec 19. Epub 2019 Dec 19.

Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.

Microcystic adnexal carcinoma is a locally aggressive sweat gland carcinoma characterized by its infiltrative growth and histopathologic overlap with benign adnexal tumors, often posing challenges to both diagnosis and management. Understanding the molecular underpinnings of microcystic adnexal carcinoma may allow for more accurate diagnosis and identify potential targetable oncogenic drivers. We characterized 18 microcystic adnexal carcinomas by targeted, multiplexed PCR-based DNA next-generation sequencing of the coding sequence of over 400 cancer-relevant genes. Read More

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http://dx.doi.org/10.1038/s41379-019-0424-4DOI Listing
December 2019

State of the art of Mohs surgery for rare cutaneous tumors in the Spanish Registry of Mohs Surgery (REGESMOHS).

Int J Dermatol 2020 Mar 28;59(3):321-325. Epub 2019 Nov 28.

Fundación Piel Sana Academia Española de Dermatología, Madrid, Spain.

Background: The use of Mohs micrographic surgery (MMS) for rare cutaneous tumors is poorly defined. We aim to describe the demographics, tumor presentation and topography, surgery characteristics and complications of MMS for rare cutaneous tumors in a national registry.

Methods: Prospective cohort study of patients treated with MMS in Spain between July 2013 and June 2018. Read More

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http://dx.doi.org/10.1111/ijd.14732DOI Listing

Approaches to Perineural, Lymphovascular, and Single-Cell Disease.

Dermatol Surg 2019 12;45 Suppl 2:S118-S128

Department of Dermatology, University of Pittsburgh, Pittsburgh, PA.

Background: Mohs micrographic surgeons should be adept in identifying and managing perineural invasion (PNI), lymphovascular invasion (LVI), and single-cell spread (SCS), features denoting high-risk behavior of basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (cSCC) and microcystic adnexal carcinoma (MAC).

Objective: The purpose of this article is to review the literature and guidelines regarding the diagnosis of PNI, LVI, and SCS in BCC, cSCC, and MAC and examine the role of advanced diagnostic studies, adjuvant therapy, and reconstructive techniques of these high-risk tumors.

Materials And Methods: We performed a literature search including the following terms: PNI, LVI, SCS, BCC, cSCC, keratinocyte carcinoma, MAC, sentinel lymph node biopsy, radiation, chemotherapy, and staging. Read More

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http://dx.doi.org/10.1097/DSS.0000000000002259DOI Listing
December 2019

Axillary and elbow lymph node metastasis arising after complete excision of microcystic adnexal carcinoma of a hand: A rare presentation.

Int J Surg Case Rep 2019 17;64:154-156. Epub 2019 Oct 17.

Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. Electronic address:

Introduction: Microcystic adnexal carcinoma (MAC), a malignant transformation of adnexal structures, constitutes a rare locally aggressive malignancy of skin. Generally, the disease is associated with local invasion and distant metastases are extremely rare. We presented a case of MAC with distant metastasis after adequate wide excision. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831811PMC
October 2019

Epidemiology and Survival of Microcystic Adnexal Carcinoma by Sex in the United States.

Dermatol Surg 2019 Sep 23. Epub 2019 Sep 23.

Department of Dermatology University of Minnesota Minneapolis, Minnesota.

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http://dx.doi.org/10.1097/DSS.0000000000002167DOI Listing
September 2019
3 Reads

Long-lasting Tumour on the Upper Lip of a 28-year-old Woman: A Quiz.

Acta Derm Venereol 2019 Dec;99(13):1319-1321

Department of Dermatology and Allergy, Copenhagen University Hospital Herlev-Gentofte, DK-2830 Hellerup, Denmark.

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http://dx.doi.org/10.2340/00015555-3314DOI Listing
December 2019
2 Reads

Solid Microcystic Adnexal Carcinoma on the Thigh: An Unusual Location.

Am J Dermatopathol 2020 Feb;42(2):122-124

Department of Dermatology, Instituto Valenciano de Oncología, Valencia, Spain.

Solid carcinoma, probably the solid variant of microcystic adnexal carcinoma, is an apocrine adnexal tumor first described in 1998. The authors report an additional new case of the tumor at an unusual localization. A 78-year-old man presented with an asymptomatic firm plaque on his right thigh that had been present for 15 years. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001466DOI Listing
February 2020
4 Reads

Ln-γ 2 chain of laminin-332 is a useful marker in differentiating between benign and malignant sclerosing adnexal neoplasms.

Histopathology 2020 Jan 13;76(2):318-324. Epub 2019 Nov 13.

Department of Pathology, Fukuoka University School of Medicine and Hospital, Fukuoka, Japan.

Aims: Laminin (Ln)-γ 2, one of the chains of Ln-332, is a marker of invasive tumours and is frequently expressed as a monomer in malignant tumours. Desmoplastic trichoepithelioma (DTE), some types of basal cell carcinoma (BCC) (infiltrating and morphoeic BCC) and microcystic adnexal carcinoma (MAC) belong to a group of tumours known as sclerosing adnexal neoplasms (SAN) that are frequently difficult to differentiate and often require immunohistochemistry for diagnosis. The aim of this study was to assess the usefulness of Ln-γ 2 expression in the differential diagnosis of DTE, infiltrating/morphoeic BCC, MAC and syringoma. Read More

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http://dx.doi.org/10.1111/his.13974DOI Listing
January 2020
4 Reads

Microcystic Adnexal Carcinoma Originating in a Nevus Sebaceous: A Case Report of a 16-year-old Boy.

Acta Derm Venereol 2019 Nov;99(12):1182-1183

Department of Dermatology and Venereology, Linköping University Hospital, SE-58185 Linköping, Sweden.

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http://dx.doi.org/10.2340/00015555-3272DOI Listing
November 2019
5 Reads

Microcystic adnexal carcinoma.

Indian J Dermatol Venereol Leprol 2019 Jul 26. Epub 2019 Jul 26.

Department of Pathology, GGMC and Sir JJ Group of Hospitals, Mumbai, Maharashtra, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_677_18DOI Listing
July 2019
5 Reads
1.325 Impact Factor

Evidence-Based Clinical Practice Guidelines for Microcystic Adnexal Carcinoma: Informed by a Systematic Review.

JAMA Dermatol 2019 Jul 3. Epub 2019 Jul 3.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Importance: Microcystic adnexal carcinoma (MAC) occurs primarily in older adults of white race/ethnicity on sun-exposed skin of the head and neck. There are no formal guiding principles based on expert review of the evidence to assist clinicians in providing the highest-quality care for patients.

Objective: To develop recommendations for the care of adults with MAC. Read More

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http://dx.doi.org/10.1001/jamadermatol.2019.1251DOI Listing
July 2019
13 Reads

Evidence-Based Clinical Practice Guidelines for Management of Microcystic Adnexal Carcinoma.

JAMA Dermatol 2019 Jul 3. Epub 2019 Jul 3.

The Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, New York.

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http://dx.doi.org/10.1001/jamadermatol.2019.1008DOI Listing
July 2019
6 Reads

Microcystic adnexal carcinoma with large cysts: unusual clinical presentation and histological findings.

Eur J Dermatol 2019 Jun;29(3):337-339

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1684/ejd.2019.3586DOI Listing
June 2019
7 Reads

Microcystic Adnexal Carcinoma: A Rare, Commonly Misdiagnosed Malignancy.

Mil Med 2019 12;184(11-12):948-950

AirMed Program, MCMR-SRZ-B, 3698 Chambers Pass Ste B, JBSA Ft. Sam Houston, TX 78234.

Microcystic adnexal carcinoma (MAC) is a rare, malignant cutaneous neoplasm that often presents as an inconspicuous, benign appearing lesion. Patients most commonly are asymptomatic and present for improved cosmesis, however perineural invasion may result in local numbness, paresthesia or pruritus. Although distant metastasis is rare, MAC has an increased propensity for local invasion, often resulting in significant morbidity as late presentation and misdiagnosis are common. Read More

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http://dx.doi.org/10.1093/milmed/usz123DOI Listing
December 2019
18 Reads

Bilateral Facial Apocrine Fibrosing Hamartoma Mimicking Microcystic Adnexal Carcinoma.

Am J Dermatopathol 2019 Oct;41(10):767-770

Dermatopathology Department, Dermatopathologie Friedrischafen/Bodensee, Friedrischafen, Germany.

An otherwise healthy 50-year-old woman was evaluated for the presence of 2 erythematous, and slightly pruritic plaques, involving both cheeks for 30 years. Left-side skin biopsy showed a diffuse proliferation of ductal structures horizontally arranged and involving the reticular dermis that resembled tubular adenoma embedded in a sclerotic stroma and surrounded by a peculiar periductal desmoplasia. Nuclear atypia or mitosis was not found. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001433DOI Listing
October 2019
10 Reads

Factors associated with the utilization of Mohs micrographic surgery in the treatment of microcystic adnexal carcinoma.

J Am Acad Dermatol 2019 08 2;81(2):640-642. Epub 2019 Feb 2.

Department of Dermatology, University of Minnesota, Minneapolis, Minnesota.

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https://linkinghub.elsevier.com/retrieve/pii/S01909622193018
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http://dx.doi.org/10.1016/j.jaad.2019.01.069DOI Listing
August 2019
13 Reads

Inherited desmoplastic trichoepitheliomas.

Clin Exp Dermatol 2019 Oct 29;44(7):e238-e239. Epub 2019 Jan 29.

Dermatology Department, West Glasgow Ambulatory Care Hospital, NHS Greater Glasgow and Clyde, Dalnair Street, Yorkhill, Glasgow, G3 8SJ, UK.

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http://dx.doi.org/10.1111/ced.13876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766857PMC
October 2019

Successful treatment of microcystic adnexal carcinoma on the philtrum with oral S-1 monotherapy.

J Dermatol 2019 Jun 21;46(6):e208-e209. Epub 2019 Jan 21.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1111/1346-8138.14770DOI Listing
June 2019
8 Reads

Immunoreactivity for Sox10 in Basaloid Neoplasms of The Skin.

Appl Immunohistochem Mol Morphol 2019 02;27(2):114-118

Section of Dermatopathology, Division of Surgical Pathology-Cytopathology, University of Virginia Medical Center, Charlottesville, VA.

Basaloid tumors of the skin pose a diagnostic challenge to pathologists, because the differential diagnosis is broad, sometimes with subtle differentiating features. We evaluated SOX10 expression in 120 primary cutaneous tumors with epidermal, sweat glandular, neuroendocrine/neuroectodermal, follicular, and sebaceous lineages. Our findings were compared with those of previous studies that evaluated SOX10 in tumors of the skin. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000721DOI Listing
February 2019
16 Reads

Malignant Sweat Gland Tumors.

Hematol Oncol Clin North Am 2019 02;33(1):53-71

Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA. Electronic address:

Malignant sweat gland neoplasms are a confusing area within dermatopathology, with many entities reported under several designations in the literature. This review describes the key clinical and histopathologic features of select malignant adnexal neoplasms, including porocarcinoma, papillary carcinoma, adenoid cystic carcinoma, cribriform carcinoma, apocrine hidradenocarcinoma, malignant mixed tumor of the skin, syringoid carcinoma, cylindrocarcinoma, spiradenocarcinoma, mucinous carcinoma, polymorphous sweat gland carcinoma, microcystic adnexal carcinoma, secretory carcinoma of the skin, and primary cutaneous signet ring cell carcinoma. For entities with overlapping features, differential diagnoses are discussed. Read More

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http://dx.doi.org/10.1016/j.hoc.2018.09.002DOI Listing
February 2019
14 Reads

Microcystic adnexal carcinoma of the skin in atypical site (pubic region): clinical and dermatoscopic features.

G Ital Dermatol Venereol 2020 Apr 20;155(2):231-232. Epub 2018 Sep 20.

Histopathology Service of the "Celio" Military Hospital of Rome, Rome, Italy.

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https://www.minervamedica.it/index2.php?show=R23Y9999N00A180
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http://dx.doi.org/10.23736/S0392-0488.18.05893-5DOI Listing
April 2020
18 Reads

Microcystic adnexal carcinoma of the external auditory canal.

Cutis 2018 08;102(2):E11-E13

Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, and Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Taiwan.

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August 2018
14 Reads

Solid carcinoma is a variant of microcystic adnexal carcinoma: A 14-case series.

J Cutan Pathol 2018 Dec 9;45(12):897-904. Epub 2018 Oct 9.

Dermatologist and Dermatopathologist, Friedrichshafen Dermatopathologie, Friedrichshafen, Germany.

Background: Solid carcinoma is a poorly characterized malignant apocrine neoplasm as only 16 cases have been published.

Objective: To characterize its clinical, histopathological, and immunohistochemical features.

Methods: We compiled 14 cases of solid carcinoma and clinical information were updated. Read More

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http://doi.wiley.com/10.1111/cup.13351
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http://dx.doi.org/10.1111/cup.13351DOI Listing
December 2018
50 Reads
1.560 Impact Factor

Microcystic Adnexal Carcinoma of the Nipple.

Wounds 2018 Jun;30(6):E65-E67

Division of Plastic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN.

Background: Microcystic adnexal carcinoma (MAC) is a rare infiltrative cutaneous tumor, but with its locally aggressive nature, high rate of recurrence, and rare metastatic potential, it is an important clinical entity to consider when faced with a nipple lesion. These tumors are frequently misdiagnosed based on superficial biopsy alone.

Case Report: This case of a 15-year-old girl with MAC of the nipple demonstrates the importance of having a high index of suspicion in order to obtain a diagnosis, to determine the extent of disease, and to achieve adequate resection before reconstruction. Read More

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June 2018
27 Reads

An Unusual Morphological Presentation of Cutaneous Squamous Cell Carcinoma Mimicking Microcystic Adnexal Carcinoma: A Diagnostic Pitfall.

Dermatopathology (Basel) 2018 Apr-Jun;5(2):64-68. Epub 2018 May 23.

Department of Dermatology and Venereology, University Hospital of Geneva, Geneva, Switzerland.

Cutaneous squamous cell carcinoma (SCC) exhibiting microcystic adnexal carcinoma-like differentiation is an extremely rare tumor that shows both squamous and ductal differentiation. This tumor is often misdiagnosed clinically and histologically and is confused with other malignant and benign cutaneous neoplasms. It usually occurs in middle-aged to older adults. Read More

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http://dx.doi.org/10.1159/000488981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031951PMC
May 2018
33 Reads

Sclerosing Microcystic Adenocarcinoma: Report of a Rare Case and Review of Literature.

Head Neck Pathol 2019 Jun 10;13(2):215-219. Epub 2018 Jul 10.

Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53792, USA.

Sclerosing microcystic adenocarcinoma is an exceedingly rare entity occurring in the mucosal surfaces of the head and neck that closely resembles cutaneous microcystic adnexal carcinoma. Here, we report a case of sclerosing microcystic adenocarcinoma that presented as a vague mass at the floor of the mouth in a 55-year-old woman. The pathology features and the diagnostic challenges, especially in the biopsy and margin evaluation are discussed here. Read More

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http://link.springer.com/10.1007/s12105-018-0945-z
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http://dx.doi.org/10.1007/s12105-018-0945-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513910PMC
June 2019
55 Reads

Cutaneous Squamous Cell Carcinoma With Sclerosing Features: An Uncommon and Potentially Aggressive Variant.

Am J Dermatopathol 2018 Aug;40(8):575-579

Department of Pathology, Section of Dermatopathology, University of Virginia Health System, Charlottesville, VA.

Sclerosing squamous cell carcinoma (SCC), also known as "desmoplastic" SCC, is a rare subtype of cutaneous malignancy. This variant is clinically significant because it is associated with an increased risk of local recurrence and metastasis. We herein present 16 examples of sclerotic SCC of the skin in 8 men and 3 women, with a median age of 66 years. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001169DOI Listing
August 2018
43 Reads

Utility of Ber-EP4 and MOC-31 in Basaloid Skin Tumor Detection.

Appl Immunohistochem Mol Morphol 2019 09;27(8):584-588

Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada.

Ber-EP4 has been the traditional immunostain used for the detection of basaloid skin tumors. Recently, MOC-31 has shown be superior to Ber-EP4 in the detection of basosquamous basal cell carcinoma (BCC) and many centers are now using both Ber-EP4 and MOC-31 antibodies together to detect these lesions. The objective of this study was to compare the utility of using both Ber-EP4 and MOC-31 immunostains in the detection of basaloid skin tumors and to better characterize the previously unknown staining properties of MOC-31 in cutaneous lesions. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000664DOI Listing
September 2019
26 Reads

[Microcystic adnexal carcinoma: A case report].

Ann Pathol 2018 Jun 2;38(3):198-201. Epub 2018 Apr 2.

Service de dermatologie, CHU de Caen, avenue côte-de-nacre, 14033 Caen, France.

We report a case of microcystic adnexal carcinoma in a 80-year-old woman. This is a rare malignant adnexal cutaneous tumor with glandular and follicular differentiation, rare, often asymptomatic, with late diagnosis and slow growth, locally aggressive and rarely metastatic. The distinction with other benign and malignant skin tumors is difficult. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02426498183001
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http://dx.doi.org/10.1016/j.annpat.2018.03.001DOI Listing
June 2018
29 Reads

Microcystic adnexal carcinoma-diagnostic criteria and therapeutic methods: case report and review of the literature.

Int J Oral Maxillofac Surg 2018 Oct 27;47(10):1258-1262. Epub 2018 Mar 27.

Department of Maxillofacial Surgery, University Hospital Dubrava, Zagreb, Croatia. Electronic address:

Microcystic adnexal carcinoma (MAC) is a rare, infiltrating, locally aggressive cutaneous neoplasm of combined follicular and eccrine/apocrine histogenesis, usually presenting on the upper lip or face. Differentiation from other adnexal tumours is very important because the clinical management of these tumours is radically different, and misdiagnosis may lead to incorrect treatment. A case of recurrent MAC in the upper lip, treated with multiple excisions and postoperative radiation therapy (PORT), is presented herein. Read More

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http://dx.doi.org/10.1016/j.ijom.2018.03.001DOI Listing
October 2018
13 Reads

Demographics and outcomes of microcystic adnexal carcinoma.

J Am Acad Dermatol 2018 Oct 17;79(4):756-758. Epub 2018 Mar 17.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183046
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http://dx.doi.org/10.1016/j.jaad.2018.03.010DOI Listing
October 2018
36 Reads

A case and literature review of orbital microcystic adnexal carcinoma.

Orbit 2018 Dec 20;37(6):472-475. Epub 2018 Feb 20.

a Department of Ophthalmology , Leicester Royal Infirmary , Leicester , England, UK.

Microcystic adnexal carcinoma (MAC) is a very rare and locally aggressive sweat gland tumour. MAC has been well reported presenting as a periocular cutaneous lesion, rarely with subsequent direct orbital invasion and only once as a primary orbital lesion. Local recurrence is frequent after primary surgical excision and the role of adjuvant radiotherapy is ill-defined. Read More

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http://dx.doi.org/10.1080/01676830.2018.1440607DOI Listing
December 2018
43 Reads

Microcystic adnexal carcinoma with sebaceous differentiation: Three cases.

J Cutan Pathol 2018 Apr 15;45(4):290-295. Epub 2018 Feb 15.

Private Practice, Friedrischafen, Friedrichshafen Dermatopathologie, Friedrischafen, Germany.

Microcystic adnexal carcinoma (MAC) is a low-grade malignant tumor of the skin. Histologically, this tumor shows a biphasic pattern, with cords and nests of basaloid cells, as well as keratin horn cysts. This biphasic histological appearance has been interpreted by some authors as a sign of double eccrine and folliculosebaceous-apocrine differentiation, whereas some other authors defend a solely eccrine differentiation. Read More

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http://dx.doi.org/10.1111/cup.13109DOI Listing
April 2018
18 Reads

Microcystic adnexal carcinoma of the orbit mimicking pagetoid sebaceous gland carcinoma.

Orbit 2018 Jun 20;37(3):235-237. Epub 2017 Oct 20.

d Medical Director, MN Eye Hospital , Chennai , India.

Microcystic adnexal carcinoma (MAC) is a rare malignancy of sweat glands that has been reported most often on the face in the form of a cutaneous lesion, with the potential for deeper invasion. The synonyms of MAC include sclerosing sweat duct carcinoma, syringomatous carcinoma, and malignant syringoma. Clinically, MAC in the periocular area has been misdiagnosed as basal cell carcinoma, squamous cell carcinoma, or even chalazia. Read More

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http://dx.doi.org/10.1080/01676830.2017.1383472DOI Listing
June 2018
20 Reads

Microcystic adnexal carcinoma mimicking basal cell carcinoma.

JAAD Case Rep 2017 Nov 9;3(6):492-494. Epub 2017 Oct 9.

Department of Dermatology, University Hospital of Salamanca, Salamanca, Spain.

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http://dx.doi.org/10.1016/j.jdcr.2017.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635954PMC
November 2017
21 Reads

Metastatic Microcystic Adnexal Carcinoma with DNA Sequencing Results and Response to Systemic Antineoplastic Chemotherapy.

Anticancer Res 2017 09;37(9):5109-5111

Section of Satellite Oncology, Moffitt Cancer Center and Division of Hematology/Oncology, Morsani School of Medicine, University of South Florida, Tampa, FL, U.S.A.

Microcystic adnexal carcinoma (MAC) is a rare cutaneous malignancy. Due to its rarity, the molecular characteristics and treatment for metastatic MAC remain undefined. Here we present, as far as we are aware, the first case of metastatic MAC with DNA sequencing results indicating a mutation in TP53 and chromosomal losses in cyclin dependent kinase inhibitor 2A (CDKN2A) and cyclin dependent kinase inhibitor 2B (CDKN2B). Read More

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http://dx.doi.org/10.21873/anticanres.11929DOI Listing
September 2017
48 Reads

Microcystic Adnexal Carcinoma and a Summary of Other Rare Malignant Adnexal Tumours.

Authors:
Arif Aslam

Curr Treat Options Oncol 2017 08;18(8):49

St Helens and Knowsley Teaching Hospitals NHS Trust, Marshalls Cross Road, St Helens, WA9 3DA, UK.

Opinion Statement: Microcystic adnexal carcinoma (MAC) is a rare, slow-growing, infiltrative malignant tumour most commonly found on the head and neck. It often presents as a solitary skin-coloured or yellow papule, plaque or nodule. Ultraviolet radiation, immunosuppression and ionising radiation are possible risk factors. Read More

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http://dx.doi.org/10.1007/s11864-017-0491-zDOI Listing
August 2017
62 Reads

Microcystic Adnexal Carcinoma: A Review of the Literature.

Dermatol Surg 2017 Aug;43(8):1012-1016

*Division of Dermatology, Department of Internal Medicine, Washington University, St. Louis, Missouri; †Department of Pathology and Immunology, Washington University, St. Louis, Missouri.

Background: Microcystic adnexal carcinoma (MAC) is a rare, locally aggressive cutaneous neoplasm that commonly occurs on the face.

Objective: The purpose of this article is to comprehensively review the current literature on MAC pertaining to epidemiology, pathogenesis, clinical presentation, histology, immunohistochemistry, prognosis, follow-up, and treatment.

Materials And Methods: An extensive literature review was conducted using OVID MEDLINE and PubMed to identify articles relating to MAC. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001142DOI Listing
August 2017
61 Reads

Image Gallery: Microcystic adnexal carcinoma (syringomatous carcinoma and sclerosing sweat duct carcinoma) as an extensive sclerotic erythematous plaque with telangiectasia over the face.

Br J Dermatol 2017 06;176(6):e122

Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

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http://dx.doi.org/10.1111/bjd.15479DOI Listing
June 2017
42 Reads

Longstanding microcystic adnexal carcinoma in a child.

Int J Dermatol 2017 Jul 23;56(7):782-783. Epub 2017 May 23.

Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1111/ijd.13657DOI Listing
July 2017
36 Reads

Update on Malignant Sweat Gland Tumors.

Surg Pathol Clin 2017 Jun 27;10(2):383-397. Epub 2017 Mar 27.

Department of Pathology, Western General Hospital, Alexander Donald Building, 1st Floor, Crewe Road, Edinburgh EH4 2XU, UK. Electronic address:

Malignant sweat gland tumors are rare cutaneous neoplasms, traditionally separated according to their behavior into low- and high-grade malignant. There is significant morphologic overlap, and outright malignant tumors may show relatively bland histologic features. They may, therefore, be mistaken easily for benign neoplasms. Read More

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http://dx.doi.org/10.1016/j.path.2017.01.010DOI Listing
June 2017
17 Reads