47,017 results match your criteria Microcirculation [Journal]


Reduction of cerebral blood flow in community-based adults with subclinical cerebrovascular atherosclerosis: A 3.0T magnetic resonance imaging study.

Neuroimage 2018 Dec 12. Epub 2018 Dec 12.

Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China. Electronic address:

Reduction in cerebral blood flow (CBF), one of the major metrics for cerebral perfusion, is associated with many brain disorders. Therefore, early characterization of CBF prior to occurrence of symptoms is essential for prevention of cerebral ischemic disorders. We hypothesized that large artery atherosclerosis might be a potential indicator for decline in cerebral perfusion. Read More

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December 2018
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A review of the mechanism of action of Dantonic for the treatment of chronic stable angina.

Biomed Pharmacother 2019 Jan 5;109:690-700. Epub 2018 Nov 5.

Pharmacology & Toxicology Research Centre, The State Key Laboratory of Core Technology in Innovative Chinese Medicine, Tasly Academy, Tasly Holding Group Co., Ltd, Tianjin 300410, China; School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Chronic stable angina (CSA) presents as a complication of coronary heart disease, leading to a high incidence and mortality rate worldwide. Dantonic or Compound Danshen Dripping Pills (CDDP) is a well-known traditional Chinese medicine used for the treatment of myocardial ischemic diseases, such as angina pectoris (AP), myocardial infarction, and sudden death. Dantonic has been extensively utilized in clinical practice in China for more than 14 years and has proved to be an effective therapy for the treatment of many myocardial ischemic diseases since its approval by CFDA in 1994. Read More

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January 2019

Methods to Label, Image, and Analyze the Complex Structural Architectures of Microvascular Networks.

Microcirculation 2018 Dec 12:e12520. Epub 2018 Dec 12.

Department of Biomedical Engineering, 415 Lane Road, University of Virginia, Charlottesville, VA, 22908.

Microvascular networks play key roles in oxygen transport and nutrient delivery to meet the varied and dynamic metabolic needs of different tissues throughout the body, and their spatial architectures of interconnected blood vessel segments are highly complex. Moreover, functional adaptations of the microcirculation enabled by structural adaptations in microvascular network architecture are required for development, wound healing, and often invoked in disease conditions, including the top eight causes of death in the Unites States. Effective characterization of microvascular network architectures is not only limited by the available techniques to visualize microvessels, but also reliant on the available quantitative metrics that accurately delineate between spatial patterns in altered networks. Read More

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December 2018

A case of Werner's syndrome with cardiac syndrome X and heart failure with preserved ejection fraction.

J Cardiol Cases 2015 Dec 1;12(6):195-198. Epub 2015 Oct 1.

Department of Cardiovascular Medicine, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.

We herein report a case of Werner's syndrome (WS) with cardiac syndrome X (CSX) and heart failure with preserved ejection fraction (HFpEF), receiving nicorandil treatment. A 58-year-old woman with chest discomfort on exercise was suspected of having effort-angina pectoris because of broad ST-depression in electrocardiogram of exercise test and reversible defect in the posterior-wall portion of left ventricle in exercise thallium myocardial scintigraphy. This patient also exhibited HFpEF, diagnosed by increased ratio of early-transmitral-flow-velocity to tissue-Doppler early-diastolic mitral annular velocity (E/e') in echocardiography and plasma B-type natriuretic peptide (BNP) levels. Read More

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December 2015

Melanoma tumour vasculature heterogeneity: from mice models to human.

J Cancer Res Clin Oncol 2018 Dec 13. Epub 2018 Dec 13.

UMR Inserm 1066, CNRS 6021, Université d'Angers, CHU, IBS, IRIS, MINT, UNIV Angers, INSERM, CNRS, Université Bretagne Loire, IBS-CHU, 4, rue Larrey, 49933, Angers, France.

Tumour angiogenesis is defined by an anarchic vasculature and irregularities in alignment of endothelial cells. These structural abnormalities could explain the variability in distribution of nanomedicines in various tumour models. Then, the main goal of this study was to compare and to characterize the tumour vascular structure in different mouse models of melanoma tumours (B16F10 and SK-Mel-28) and in human melanomas from different patients. Read More

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December 2018
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Frame Registration for Motion Compensation in Imaging Photoplethysmography.

Sensors (Basel) 2018 Dec 8;18(12). Epub 2018 Dec 8.

Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough LE11 3TU, UK.

Imaging photoplethysmography (iPPG) is an emerging technology used to assess microcirculation and cardiovascular signs by collecting backscattered light from illuminated tissue using optical imaging sensors. An engineering approach is used to evaluate whether a silicone cast of a human palm might be effectively utilized to predict the results of image registration schemes for motion compensation prior to their application on live human tissue. This allows us to establish a performance baseline for each of the algorithms and to isolate performance and noise fluctuations due to the induced motion from the temporally changing physiological signs. Read More

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December 2018

Microcirculation disorders of the oral cavity in patients with primary Raynaud's Phenomenon.

Pol Arch Intern Med 2018 Dec 13. Epub 2018 Dec 13.

INTRODUCTION Raynaud Phenomenon is a medical condition in which spasm of arteries cause episodes of reduced blood flow. Potential disorders in the microcirculation R2.1a of the oral mucosa may promote the occurrence of lesions. Read More

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December 2018

Ca Signalling in Pericytes.

Adv Exp Med Biol 2018 ;1109:95-109

Department of Pharmacology, University of Oxford, Oxford, UK.

Microcirculation is the generic name for the finest level of the circulatory system and consists of arteriolar and venular networks located upstream and downstream of capillaries, respectively. Anatomically arterioles are surrounded by a monolayer of spindle-shaped smooth muscle cells (myocytes), while terminal branches of precapillary arterioles, capillaries and all sections of postcapillary venules are surrounded by a monolayer of morphologically different perivascular cells (pericytes). Pericytes are essential components of the microvascular vessel wall. Read More

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January 2018

Reprint of: Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention: JACC Health Promotion Series.

J Am Coll Cardiol 2018 Dec;72(23 Pt B):3071-3086

Division of Vascular Endothelium and Microcirculation, Department of Medicine III, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

The primary objective of this study was to analyze the most up-to-date evidence regarding whether and how blood sugar regulation influences cardiovascular health promotion and disease prevention by carrying out an umbrella review. Three separate, systematic literature searches identified 2,343 papers in total. Overall, 44 studies were included for data extraction and analysis. Read More

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December 2018

Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature.

J Crit Care 2018 Dec 5;50:138-143. Epub 2018 Dec 5.

Department of Critical Care Medicine (707), Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, the Netherlands.

The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients. Read More

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December 2018
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Renal intraparenchymal resistive index: the ultrasonographic answer to many clinical questions.

J Nephrol 2018 Dec 11. Epub 2018 Dec 11.

Nephrology and Dialysis Unit, "S. Giovanni di Dio" Hospital, Agrigento, Italy.

The use of renal resistive indices (RRIs) for the study of renal microcirculation has in the past been proposed for the identification of renal organ damage or even to specifically identify injury to some areas of the renal parenchyma. Nevertheless, according to the most recent evidences from literature this organ-based conception of RRIs has been proven to be partial and unable to explain the RRIs variations in clinical settings of sepsis or combined organ failure of primitively extrarenal origin or, more generally, the deep connection between RRIs and hemodynamic factors such as compliance and pulsatility of the large vessels. The aim of this review is to explain the physiopathological basis of RRIs determination and the most common interpretative errors in their analysis. Read More

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December 2018

Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis.

Oxid Med Cell Longev 2018 13;2018:6053492. Epub 2018 Nov 13.

Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brazil.

The Mediterranean diet, rich in olive oil, is beneficial, reducing the risk of cardiovascular diseases and cancer. Olive oil is mostly composed of the monounsaturated fatty acid omega-9. We showed omega-9 protects septic mice modulating lipid metabolism. Read More

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November 2018
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Organ-Specific Mechanisms of Transendothelial Neutrophil Migration in the Lung, Liver, Kidney, and Aorta.

Front Immunol 2018 27;9:2739. Epub 2018 Nov 27.

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität München, Munich, Germany.

Immune responses are dependent on the recruitment of leukocytes to the site of inflammation. The classical leukocyte recruitment cascade, consisting of capture, rolling, arrest, adhesion, crawling, and transendothelial migration, is thoroughly studied but mostly in model systems, such as the cremasteric microcirculation. This cascade paradigm, which is widely accepted, might be applicable to many tissues, however recruitment mechanisms might substantially vary in different organs. Read More

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November 2018

Approach of minimal invasive monitoring and initial treatment of the septic patient in emergency medicine.

Open Access Emerg Med 2018 20;10:183-191. Epub 2018 Nov 20.

Emergency Medicine, Universidad del Rosario, Bogotá, Colombia.

Sepsis and septic shock constitute a complex disease condition that requires the engagement of several medical specialties. A great number of patients with this disease are constantly admitted to the emergency department, which warrants the need for emergency physicians to lead in the recognition and early management of septic patients. Timely and appropriate interventions may help reduce mortality in a disease with an unacceptably high mortality rate. Read More

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November 2018
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Contribution of Nail Fold Videocapillaroscopy in Patients with Early Inflammatory Arthritis.

Curr Health Sci J 2015 Jul-Sep;41(3):233-238. Epub 2015 Mar 15.

Rheumatology Department, University of Medicine and Pharmacy of Craiova, Faculty of Medicine, Romania.

Background: Early inflammatory arthritis (EIA) a condition defined by joint swelling, with or without morning stiffness, and/or swelling of metacarpophalangeal and/or metatarsophalangeal joints. Nail fold video-capillaroscopy (NVC) is important for the evaluation of microcirculation in vivo. There are limited data about the role of NVC in EIA. Read More

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Takotsubo cardiomyopathy in two patients with microvascular angina.

J Cardiol Cases 2015 Jul 2;12(1):26-29. Epub 2015 May 2.

Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.

We present two cases in which takotsubo cardiomyopathy (TC) developed immediately after a diagnosis of microvascular angina had been established. One patient who had been diagnosed as having endothelium-dependent microvascular angina (microvascular spasm) developed TC three weeks after the initial admission. The other patient was diagnosed as having endothelium-independent microvascular angina (decreased coronary flow reserve) and subsequently developed TC after the discontinuation of nicorandil treatment. Read More

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Recurrence of Takotsubo cardiomyopathy with coronary slow flow phenomenon.

J Cardiol Cases 2012 Apr 16;5(2):e100-e106. Epub 2012 Mar 16.

Department of Cardiology, Saga Prefectural Hospital Koseikan, 1-12-9 Mizugae, Saga, Japan.

This report presents the case of a 54-year-old female with Takotsubo cardiomyopathy that recurred 12 years after the first episode. The coronary angiography at the first admission revealed ergonovine-induced coronary vasoconstriction in the left coronary artery, and recurrence recurred after the interruption of vasodilator therapy to prevent vasospasm. In addition, the coronary angiography both in the first and second event demonstrated coronary slow flow phenomenon, which improved after the intracoronary administration of nicorandil. Read More

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April 2012
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Coronary artery tree and myocardial perfusion in patients with tako-tsubo cardiomyopathy: Evaluation with coronary digital subtraction angiography.

J Cardiol Cases 2011 Oct 9;4(2):e71-e75. Epub 2011 Aug 9.

Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto City, Japan.

Tako-tsubo cardiomyopathy is characterized by transient left ventricular contractile dysfunction. The precise etiology of tako-tsubo cardiomyopathy remains to be elucidated. We performed coronary angiography in two patients with tako-tsubo cardiomyopathy and evaluated the coronary microcirculation by digital subtraction angiography (DSA). Read More

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October 2011

Effects of crystalloids and colloids on microcirculation, central venous oxygen saturation, and central venous-to-arterial carbon dioxide gap in a rabbit model of hemorrhagic shock.

J Anesth 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiovascular Surgery, Tokyo Women's Medical University, 8-1, Kawadacho Shinjuku-ku, Tokyo, 162-8666, Japan.

Objective: The effects of hydroxyethyl starch (HES) on microcirculation, central venous oxygen saturation (ScvO), and the central venous-to-arterial carbon dioxide gap (dCO) are studied in a rabbit model of hemorrhagic shock for elucidating the advantages and drawbacks of resuscitation with HES compared with crystalloids.

Methods: An ear chamber and sublingual mucosa were used to examine blood vessels by intravital microscopy. Hemorrhagic shock was induced by removing nearly half of the blood volume. Read More

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December 2018

Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5847-5853

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Purpose: To differentiate the four layers of the retinal vessel network in the human macula and examine their morphologic features using high-resolution optical coherence tomography angiography (HR-OCTA).

Methods: Macular areas measuring 464 × 464 pixels of 10 right eyes of 10 healthy subjects without ocular disease were scanned 10 times using a HR-OCTA device. Averaged OCTA images were created. Read More

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December 2018

Myocardial flow reserve assessed by cardiac 82Rb positron emission tomography/computed tomography is associated with albumin excretion in patients with Type 1 diabetes.

Eur Heart J Cardiovasc Imaging 2018 Dec 7. Epub 2018 Dec 7.

Complications Research, Steno Diabetes Center Copenhagen, Niels Steensens Vej 2, Gentofte, Denmark.

Aims: To evaluate myocardial flow reserve (MFR) and coronary artery calcium (CAC) in persons with Type 1 diabetes with or without albuminuria and in non-diabetic controls. MFR reflects the function of large epicardial arteries and myocardial microcirculation. CAC represents structural aspects of atherosclerosis. Read More

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December 2018

Assessing myocardial ischaemia in epicardial coronaries and the microcirculation.

Eur Heart J 2018 Dec;39(46):4047-4050

Imperial College and Director of Research, Education & Development, Royal Brompton and Harefield Hospitals London, UK.

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December 2018

Emerging Evidence concerning the Role of Sirtuins in Sepsis.

Crit Care Res Pract 2018 8;2018:5489571. Epub 2018 Nov 8.

Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, No. 1023, South Shatai Road, Baiyun District, Guangzhou 510515, Guangdong, China.

Sepsis, a dysregulated host response to infection, is a major public health concern. Though experimental and clinical studies relating to sepsis are increasing, the mechanism of sepsis is not completely understood. To date, numerous studies have shown that sirtuins (silent mating type information regulation 2 homolog), which belong to the class III histone deacetylases, may have a varied, or even opposite, effect in the pathogenesis of sepsis. Read More

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November 2018

[Cytophlavin inclusion in complex treatment of diabetic foot syndrome with signs of lower limb blood vessels medicalcinosis].

Khirurgiia (Mosk) 2018 (10):69-72

St. Petersburg Medical and Social Institute, St. Petersburg, Russia.

The aim of this study was to evaluate the effect of cytoflavin inclusion in therapy regimens of patients with diabetic foot syndrome and medicalcinosis on the microcirculation of the lower limb blood vessels. For this purpose, 64 patients with type II diabetes mellitus (subcompensated form), diabetic foot syndrome and signs of medicalcinosis foot blood vessels of various severity were examined. All patients were divided into 2 groups depending on the therapy scheme: patients of group I (33 people) received insulin, antibiotics, disaggregants, statins, anti-inflammatory drugs, painkillers, detoxification therapy. Read More

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January 2018

[Long-term outcomes of spinal neurostimulation in patients with critical lower limb ischemia].

Khirurgiia (Mosk) 2018 (10):27-33

Meshalkin National Medical Research Center of Healthcare Ministry of Russia, Novosibirsk, Russia.

Aim: To evaluate long-term outcomes of spinal neurostimulation (SNS) in patients with critical lower limb ischemia (CLI).

Material And Methods: Long-term outcomes of SNS were assessed in 52 CLI patients. Changes of clinical status were considered by using of Rutherford R. Read More

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January 2018
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Intranasal Calcitonin Gene-Related Peptide Protects Against Focal Cerebral Ischemic Injury in Rats Through the Wnt/β-Catenin Pathway.

Med Sci Monit 2018 Dec 7;24:8860-8869. Epub 2018 Dec 7.

Key Lab of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, China (mainland).

BACKGROUND Intranasal calcitonin gene-related peptide (CGRP) delivery offers a noninvasive method of bypassing the blood-brain barrier for the delivery of CGRP to the brain. Here, we first reported the therapeutic benefits of intranasal CGRP delivery in rats following middle cerebral artery occlusion (MCAO). MATERIAL AND METHODS Real-time quantitative polymerase chain reaction (RT-qPCR) assay, enzyme-linked immunosorbent assay (ELISA), rat MCAO model, TTC (2, 3, 5-triphenyltetrazolium chloride) staining, hematoxylin and eosin (H & E) staining, Morris water maze test, TUNEL assay, immunofluorescence, and western blot assay were used to investigate the role of CGRP in rats. Read More

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December 2018

Effect of Early Abdominal Paracentesis Drainage on the Injury of Intestinal Mucosa and Intestinal Microcirculation in Severe Acute Pancreatitis Rats.

Pancreas 2019 Jan;48(1):e6-e8

Center of General Surgery General Hospital of Chengdu Military Command and Department of General Surgery Dujiangyan Medical Center Chengdu, China Center of General Surgery General Hospital of Chengdu Military Command Chengdu, China

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January 2019

Effects of treatment with rituximab on microcirculation in patients with long-term systemic sclerosis.

BMC Res Notes 2018 Dec 10;11(1):874. Epub 2018 Dec 10.

State University of Rio de Janeiro, Rio de Janeiro, Brazil.

Objective: To investigate the effect of rituximab on microcirculation in long-term SSc.

Results: Four patients with diffuse SSc over 3 years of disease received rituximab cycles of two 1-g infusions every 6 months for 2 years. Videocapillaroscopy was performed at baseline, 12 months, and 24 months and semi-quantitative scoring of videocapillaroscopy abnormalities was performed and the microangiopathy evolution score (MES: range 0-9) was calculated. Read More

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December 2018

An integrated method for quantitative morphometry and oxygen transport modelling in striated muscle.

J Appl Physiol (1985) 2018 Dec 6. Epub 2018 Dec 6.

Biomedical Sciences, University of Leeds, United Kingdom.

Identifying structural limitations in O transport is primarily restricted by current methods employed to characterise the nature of physiological remodelling. Inadequate resolution or breadth of available data has impaired development of routine diagnostic protocols and effective therapeutic strategies. Understanding O transport within striated muscle faces major challenges, most notably in quantifying how well individual fibres are supplied by the microcirculation, which has necessitated exploring tissue O supply using theoretical modelling of diffusive exchange. Read More

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December 2018
2 Reads

Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment.

J Osteoporos 2018 5;2018:1585749. Epub 2018 Nov 5.

Department of Traumatology and Orthopedics, Kursk State Medical University, No-3 Karl Marx Street, Kursk 305000, Russia.

The experiment was carried out on 120 female white Wistar rats, to study the endothelio- and osteoprotective action of the combination of rosuvastatin with L-norvaline in the model of experimental osteoporosis. It was found that, after ovariectomy in rats, endothelial dysfunction of the vessels of the microcirculatory bed of bone tissue develops, leading to the appearance of osteoporosis, but the combination of the studied drugs prevents the decrease in the level of microcirculation in the bone tissue, thereby preventing the thinning of bone trabeculae and preventing the occurrence of microfractures in them. Read More

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November 2018
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Microfluidic Deformability Study of an Innovative Blood Analogue Fluid Based on Giant Unilamellar Vesicles.

J Funct Biomater 2018 Dec 4;9(4). Epub 2018 Dec 4.

MEtRICs, Mechanical Engineering Department, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal.

Blood analogues have long been a topic of interest in biofluid mechanics due to the safety and ethical issues involved in the collection and handling of blood samples. Although the current blood analogue fluids can adequately mimic the rheological properties of blood from a macroscopic point of view, at the microscopic level blood analogues need further development and improvement. In this work, an innovative blood analogue containing giant unilamellar vesicles (GUVs) was developed to mimic the flow behavior of red blood cells (RBCs). Read More

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December 2018
4 Reads

Neuraxial anesthesia is less harmful to the endothelial glycocalyx during elective joint surgery compared to general anesthesia1,2.

Clin Hemorheol Microcirc 2018 Nov 29. Epub 2018 Nov 29.

Department of Anaesthesiology and Intensive Care, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic.

Background: Damage of the endothelial glycocalyx (EG) has been described during surgery, but the effect of different anesthesia techniques remains unknown. Perfused boundary region (PBR) evaluated by side-stream dark field (SDF) imaging of the sublingual microcirculation enables in vivo EG assessment. PBR values are inversely related to the EG thickness. Read More

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November 2018
2 Reads

Effects of dietary supplementation with creatine on homocysteinemia and systemic microvascular endothelial function in individuals adhering to vegan diets.

Fundam Clin Pharmacol 2018 Dec 3. Epub 2018 Dec 3.

National Institute of Cardiology, Ministry of Health, Rio de Janeiro, Brazil.

The incidence of cardiovascular diseases in vegetarian individuals is lower than that in the general population. Nevertheless, individuals who adhere to vegan diets have a higher prevalence of hyperhomocysteinemia with eventual adverse effects on vascular reactivity. Creatine supplementation (CrS) reduces plasma homocysteine levels and enhances vascular reactivity in the microcirculation. Read More

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December 2018

Seven consecutive days of remote ischaemic preconditioning improves cutaneous vasodilatory capacity in young adults.

J Physiol 2018 Dec 2. Epub 2018 Dec 2.

Faculty of Physical Education, University of Brasilia, Federal District, Brazil.

Key Points: Remote ischaemic preconditioning (RIPC), induced by brief bouts of ischaemia followed by reperfusion, confers vascular adaptations that protect against subsequent bouts of ischaemia. However, the effect of RIPC repeated over several days on the human microcirculation is unknown. Using skin as a model, microvascular function was assessed at a control and a NO-inhibited area of skin before, after, and 1 week after administering seven consecutive days of repeated RIPC on the contralateral arm. Read More

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December 2018

Astaxanthin ameliorates cardiomyocyte apoptosis after coronary microembolization by inhibiting oxidative stress via Nrf2/HO-1 pathway in rats.

Naunyn Schmiedebergs Arch Pharmacol 2018 Nov 30. Epub 2018 Nov 30.

Department of Cardiology, Tangdu Hospital, Air Force Military Medical University, Xinsi Road, Xi'an, 710000, China.

Coronary microembolization (CME) caused by physical obstruction in coronary microcirculation induces myocardial apoptosis and cardiac dysfunction, and it was reported that the inactivation of the Nrf2/HO-1 signaling was involved in this process. Astaxanthin (AST) is a reddish pigment that belongs to keto-carotenoids. It is also a potent antioxidant and has been reported to activate Nrf2/HO-1 signaling in vein endothelial cells. Read More

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November 2018

Changes in Ganglion Cell-Inner Plexiform Layer Thickness and Retinal Microvasculature in Hypertension: An OCT Angiography Study.

Am J Ophthalmol 2018 Nov 28. Epub 2018 Nov 28.

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea. Electronic address:

Objective: To investigate retinal blood flow in patients with hypertension using optical coherence tomography angiography (OCTA) and the relationship between blood flow metrics and ganglion cell-inner plexiform layer (GC-IPL) thickness.

Design: Retrospective, cross-sectional study.

Methods: A total of 201 eyes from 117 healthy subjects and 84 hypertensive patients without any ocular abnormalities were included. Read More

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November 2018
3 Reads

Photoacoustic microscopy for evaluating a lipopolysaccharide-induced inflammation model in mice.

J Biophotonics 2018 Dec 4:e201800251. Epub 2018 Dec 4.

University of Michigan-Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University, Shanghai, China.

Photoacoustic microscopy (PAM) is a noninvasive imaging technique and is excellent to study structural and functional changes in the microcirculation. In this work, a lipopolysaccharide (LPS)-induced inflammation model in mice is noninvasively evaluated by PAM. PAM is used to image the microvascular structural changes in mice for 8 hours after the LPS with different concentrations is applied. Read More

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December 2018
3 Reads

Metabolic Changes Induced by High-Fat Meal Evoke Different Microvascular Responses in Accordance with Adiposity Status.

Biomed Res Int 2018 1;2018:5046508. Epub 2018 Nov 1.

Laboratory for Clinical and Experimental Research on Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ 20550-013, Brazil.

Background: Frequently, ingestion of lipids exceeds our daily requirements and constantly exposes humans to circulating lipid overload which may lead to endothelial dysfunction (ED), the earliest marker of atherosclerosis. Nailfold videocapillaroscopy (NVC) technique can detect ED on microcirculation. Using NVC, we aimed to demonstrate if metabolic alterations evoked by high-fat meals can act differently on microvascular endothelial reactivity in lean and women with obesity. Read More

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November 2018
1 Read

High thoracic sympathetic block improves coronary microcirculation disturbance in rats with chronic heart failure.

Microvasc Res 2019 Mar 1;122:94-100. Epub 2018 Dec 1.

Department of Cardiac Ultrasound, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

Introduction: Coronary microcirculation disturbance plays an important role in chronic heart failure (CHF). High thoracic sympathetic block (HTSB) is effective to treat CHF, but its impact on coronary microcirculation is unclear.

Methods: Forty male Wistar rats were subcutaneously injected with isoproterenol (340 mg/kg) for 2 days. Read More

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March 2019
2 Reads

Peripapillary microvasculature in the retinal nerve fiber layer in glaucoma by optical coherence tomography angiography: focal structural and functional correlations and diagnostic performance.

Clin Ophthalmol 2018 8;12:2285-2296. Epub 2018 Nov 8.

Department of Bioengineering, University of Washington, Seattle, WA, USA.

Purpose: To quantify peripapillary microvasculature within the retinal nerve fiber layer (RNFL) in primary open-angle glaucoma (POAG) and normal eyes, determine association of perfusion parameters with structural and functional measures, and report diagnostic accuracy of perfusion parameters.

Patients And Methods: POAG and normal patients underwent 6×6 mm optic nerve head scans (Angioplex optical coherence tomography angiography [OCTA]; Cirrus HD-OCT 5000) and Humphrey Field Analyzer II-i 24-2 visual field (VF) testing. Prototype software performed semiautomatic segmentation to create RNFL en face images and quantified vessel area density (VAD), vessel skeleton density (VSD), and vessel complexity index (VCI) in the optic nerve head globally and focally. Read More

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November 2018
2 Reads

The important role of apolipoprotein A-II in ezetimibe driven reduction of high cholesterol diet-induced atherosclerosis.

Atherosclerosis 2018 Nov 16;280:99-108. Epub 2018 Nov 16.

Department of Pathophysiology, Key Lab for Shock and Microcirculation Research of Guangdong, Southern Medical University, Guangzhou, 510515, PR China. Electronic address:

Background And Aims: It has been well established that ezetimibe blocks cholesterol absorption to prevent the negative effects of a high-fat diet in atherosclerosis. However, the exact mechanism is unknown. Here we use a transgenic zebrafish, which expresses different fluorescent proteins on either endothelial cells or granulocytes and macrophages, to explore the specific mechanism of ezetimibe and its role in reducing atherosclerosis-related hypercholesteremia. Read More

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November 2018
1 Read

[The use of the osteopathic correction for the combined treatment and rehabilitation of the patients presenting with the vertebral artery syndrome].

Vopr Kurortol Fizioter Lech Fiz Kult 2018 ;95(6):34-43

FGBOU VO 'I.I. Mechnikov North-Western State Medical University', Ministry of Health of the Russian Federation, Sankt-Peterburg, Russia; FGBOU VO 'Sankt-Peterburg State University', Sankt-Peterburg, Russia.

Background: The pathological changes in the cervical spine frequently result in the disturbances of the blood supply in the vertebral-basiliar system. The degenerative-dystrophic processes in the cervical spine occupy the leading place in the pathogenesis of the vertebral artery syndrome (VAS) causing disorders of the microcirculation and innervation, as well as the restriction of mobility and the development of somatic dysfunctions. It can be assumed that the manual methods applied to manage this condition can be effective in the removal the functional abnormalities in the blood flow. Read More

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January 2018
3 Reads

[The application of combined low-intensity laser therapy for the treatment of the patients presenting with trophic ulcers associated with chronic venous insufficiency of the lower extremities].

Vopr Kurortol Fizioter Lech Fiz Kult 2018 ;95(6):27-33

O.K. Skobelkin State Scientific Centre of Laser Medicine, Russian Federal Medico-Biological Agency, Moscow, Russia.

Aim: The objective of the present study was the evaluation of the effectiveness of the combined treatment of the patients presenting with trophic ulcers associated with chronic venous insufficiency of the lower extremities of venous etiology with the application of low-intensity laser therapy (LILT) at different wavelengths.

Material And Methods: The study included the patients presenting with chronic venous insufficiency (CVI) (class C6 in accordance with the CEAP clinical classification). The ultrasonic Doppler examination (USDG) of the lower extremities revealed valvular insufficiency in the saphenous veins in 98. Read More

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January 2018
1 Read

Muscle oxygenation dynamics in response to electrical stimulation as measured with near-infrared spectroscopy: A pilot study.

J Biophotonics 2018 Nov 29:e201800320. Epub 2018 Nov 29.

Department of Photonics, National Chiao Tung University, Hsinchu, Taiwan.

Neuromuscular electrical stimulation (NMES) is used for preventing muscle atrophy and improving muscle strength in patients and healthy people. However, the current intensity of NMES is usually set at a level that causes the stimulated muscles to contract. This typically causes pain. Read More

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November 2018

Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus.

Int J Nanomedicine 2018 25;13:6829-6837. Epub 2018 Oct 25.

Department of Emergency Medicine, The First Hospital of Jiaxing, Jiaxing 314001, Zhejiang Province, China,

Background: The study of the experiment was to display the therapeutic function of insulin-loaded chitosan (insulin/chitosan) on mesenteric microcirculation via down-regulating cyclooxygenase-2 (COX-2) and vascular cell adhesion molecule (VCAM-1) expressions in rats with diabetes mellitus (DM) as compared to free insulin.

Methods: Diabetic rats were administrated with 24 U/kg insulin or 120 U/kg insulin/chitosan compounds. The blood and mesenteriums were collected, blood glucose levels, arteriole velocity, arteriole diameter, venular diameter, and hemodiapedesis were measured, and COX-2, VCAM-1 expressions were measured in mesenteriums tissues. Read More

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October 2018
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Prolonged systemic hyperglycemia does not cause pericyte loss and permeability at the mouse blood-brain barrier.

Sci Rep 2018 Nov 29;8(1):17462. Epub 2018 Nov 29.

Integrated Cardio-Metabolic Centre, Department of Medicine, Karolinska Institute, Huddinge, Sweden.

Diabetes mellitus is associated with cognitive impairment and various central nervous system pathologies such as stroke, vascular dementia, or Alzheimer's disease. The exact pathophysiology of these conditions is poorly understood. Recent reports suggest that hyperglycemia causes cerebral microcirculation pathology and blood-brain barrier (BBB) dysfunction and leakage. Read More

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November 2018
2 Reads

Coupled Modeling of Lipid Deposition, Inflammatory Response and Intraplaque Angiogenesis in Atherosclerotic Plaque.

Ann Biomed Eng 2018 Nov 28. Epub 2018 Nov 28.

School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, 210096, China.

We propose a multiphysical mathematical model by fully coupling lipid deposition, monocytes/macrophages recruitment and angiogenesis to investigate the pathophysiological responses of an atherosclerotic plaque to the dynamic changes in the microenvironment. The time evolutions of cellular (endothelial cells, macrophages, smooth muscle cells, etc.) and acellular components (low density lipoprotein, proinflammatory cytokines, extravascular plasma concentration, etc. Read More

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November 2018
3 Reads

Current Data on Effects of Long-Term Missions on the International Space Station on Skin Physiological Parameters.

Skin Pharmacol Physiol 2018 Nov 28;32(1):43-51. Epub 2018 Nov 28.

DermaTronnier, Institute for Experimental Dermatology, Witten/Herdecke University, Witten, Germany.

Background: Skin reaction to spaceflight has not really been studied yet, although the skin has a very important barrier function to protect the body and can contribute to a more general understanding of physiology. It is proposed here to make a more thorough investigation of the skin during long-term spaceflight, using noninvasive techniques.

Aims: The aim of the present Skin-B study is to investigate the kinetics and range of possible skin modifications during long-duration spaceflights and their recovery. Read More

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November 2018

Role of TLR4-p38 MAPK-Hsp27 signal pathway in LPS-induced pulmonary epithelial hyperpermeability.

BMC Pulm Med 2018 Nov 27;18(1):178. Epub 2018 Nov 27.

Department of Pathophysiology, Guangdong Province Key Laboratory for Shock and Microcirculation Research, Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Southern Medical University, Guangzhou, 510515, China.

Background: The breakdown of alveolar barrier dysfunction contributes to Lipopolysaccharide stimulated pulmonary edema and acute lung injury. Actin cytoskeleton has been implicated to be critical in regulation of epithelial barrier. Here, we performed in vivo and in vitro study to investigate role of TLR4-p38 MAPK-Hsp27 signal pathway in LPS-induced ALI. Read More

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November 2018