1,337 results match your criteria Microcirculation [Journal]


Enhanced Notch signaling modulates unproductive revascularization in response to Nitric Oxide-Angiopoietin signaling in a mouse model of peripheral ischemia.

Microcirculation 2019 Apr 11:e12549. Epub 2019 Apr 11.

Tumour Vascular Biology Laboratories, Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, Queen's Medical Centre, D Floor, West Block, University of Nottingham, Nottingham, NG7 2UH.

Arteriolargenesis can be induced by concomitant stimulation of Nitric Oxide (NO)-Angiopoietin receptor (Tie)-Vascular Endothelial Growth Factor (VEGF) signaling in the rat mesentery angiogenesis assay. We hypothesized that the same combination of exogenously added growth factors would have a positive impact on the recovery of blood flow in a model of unilateral hindlimb ischemia. NO-Tie mice had faster blood flow recovery compared to control mice, as assessed by laser speckle imaging. Read More

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April 2019
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Application of Microscale Culture Technologies for Studying Lymphatic Vessel Biology.

Microcirculation 2019 Apr 4:e12547. Epub 2019 Apr 4.

Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, USA.

Immense progress in microscale engineering technologies have significantly expanded the capabilities of in vitro cell culture systems for reconstituting physiological microenvironments that are mediated by biomolecular gradients, fluid transport, and mechanical forces. Here, we examine the innovative approaches based on microfabricated vessels for studying lymphatic biology. To help understand the necessary design requirements for microfluidic models, we first summarize lymphatic vessel structure and function. Read More

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Pancreatic Source of Protease Activity in the Spontaneously Hypertensive Rat and its Reduction During Temporary Food Restriction.

Microcirculation 2019 Apr 4:e12548. Epub 2019 Apr 4.

Department of Bioengineering, Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA, 92093-0412.

The mechanisms underlying cell and organ dysfunctions in hypertension are uncertain. The spontaneously hypertensive rat (SHR) has elevated levels of unchecked degrading proteases compared to the control Wistar Kyoto (WKY) rat. The extracellular proteases destroy membrane receptors leading to cell dysfunctions, including arteriolar constriction and elevated blood pressure. Read More

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http://dx.doi.org/10.1111/micc.12548DOI Listing
April 2019
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The reliability of cutaneous low-frequency oscillations in young healthy males.

Microcirculation 2019 Apr 1:e12546. Epub 2019 Apr 1.

Environmental Ergonomics Laboratory, Department of Kinesiology, Brock University, St. Catharines, ON, L2S 3A1, Canada.

Objective: Spectral analyses of laser-Doppler flowmetry measures enable a simple and non-invasive method to investigate mechanisms regulating skin blood flow. We assessed within-day and day-to-day variability of cutaneous spectral analyses.

Methods: Eleven young, healthy males were tested twice in 3 identical sessions, with 19 to 24 days between visits, for a total of 6 tests. Read More

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http://dx.doi.org/10.1111/micc.12546DOI Listing
April 2019
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Prediction of renal allograft chronic rejection using a model based on contrast-enhanced ultrasonography.

Microcirculation 2019 Mar 18:e12544. Epub 2019 Mar 18.

Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai Institute of Imaging Medicine, Shanghai, China.

Objective: To evaluate the application of contrast-enhanced ultrasonography (CEUS) for the diagnosis of renal allograft chronic rejection (CR).

Methods: A total of 104 patients who were suspected to have AR or CR were enrolled in this study (derivation group, n = 66; validation group, n = 38). Before biopsy, all patients received an ultrasound examination. Read More

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http://dx.doi.org/10.1111/micc.12544DOI Listing
March 2019
3 Reads

Localised pressure stimulation using turf-like structures can improve skin perfusion in the foot.

Microcirculation 2019 Mar 10:e12543. Epub 2019 Mar 10.

School of Life Sciences and Education, Staffordshire University, Stoke-on-Trent, UK.

Objective: Improving perfusion under the skin can potentially reduce ulceration and amputation risk in people with diabetic foot. Localised pressure stimulation has been proven capable of improving skin perfusion in the scalp but its effectiveness for the foot has not been tested. In this study, localised pressure stimulation was realised using flexible turf-like structures with dense vertical fibres and their ability to increase perfusion was assessed. Read More

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March 2019
7 Reads
2.565 Impact Factor

Reconstruction of coronary circulation networks: A review of methods.

Microcirculation 2019 Mar 4:e12542. Epub 2019 Mar 4.

Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.

Building anatomically accurate models of the coronary vascular system enables potentially deeper understandings of coronary circulation. To achieve this, (a) images at different levels of vascular network-arteries, arterioles, capillaries, venules, and veins-need to be obtained through suitable imaging modalities; and (b) from images, morphological and topological information needs to be extracted using image processing techniques. While there are several modalities that enable the imaging of large vessels, microcirculation imaging-capturing vessels having diameter lesser than 100 μm-has to date been typically confined to small regions of the heart. Read More

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Heat shock protein 90 does not contribute to cutaneous vasodilatation in older adults during heat stress.

Microcirculation 2019 Mar 4:e12541. Epub 2019 Mar 4.

Human and Environmental Physiology Research Unit, University of Ottawa, Ottawa, Canada.

Objectives: Heat shock protein 90 (HSP90) contributes to cutaneous vasodilatation during exercise in the heat through nitric oxide synthase (NOS)-dependent mechanisms in young adults. We hypothesized that similar responses would be observed in older middle-aged adults.

Methods: In nineteen habitually-active older middle-aged (56±5 years) men (n=9) and women (n=10), cutaneous vascular conductance (CVC) was measured at four forearm skin sites continuously treated with 1) lactated Ringers solution (Control), 2) 10 mM L-NAME (NOS inhibitor), 3) 178 μM geldanamycin (HSP90 inhibitor), or 4) 10 mM L-NAME and 178 μM geldanamycin combined. Read More

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March 2019
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Deletion of Robo4 prevents high-fat diet-induced adipose artery and systemic metabolic dysfunction.

Microcirculation 2019 Mar 1:e12540. Epub 2019 Mar 1.

Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah.

Objective: Accumulating evidence suggests the vascular endothelium plays a fundamental role in the pathophysiology of obesity by regulating the functional status of white adipose and systemic metabolism. Robo4 is expressed specifically in endothelial cells and increases vascular stability and inhibits angiogenesis. We sought to determine the role of Robo4 in modulating cardiometabolic function in response to high-fat feeding. Read More

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http://dx.doi.org/10.1111/micc.12540DOI Listing

Differential impact of severe familial hypercholesterolemia on regional skeletal muscle and organ blood flows during exercise: Effects of PDE5 inhibition.

Microcirculation 2019 Mar 1:e12539. Epub 2019 Mar 1.

Biomedical Sciences, University of Missouri, Columbia, Missouri.

Objective: Swine with familial hypercholesterolemia (FH) exhibit attenuated exercise-induced systemic vasodilation that is restored by phosphodiesterase 5 (PDE5) inhibition. Whether the impacts of FH and PDE5 inhibition to impair and restore exercise-induced vasodilation, respectively, results from tissue-specific or generalized effects remains unclear. Thus, we hypothesized that FH induces generalized impairment of skeletal muscle vasodilation that would be alleviated by PDE5 inhibition. Read More

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March 2019
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Multi-domain analysis of microvascular flow motion dynamics in NAFLD.

Microcirculation 2019 Feb 25:e12538. Epub 2019 Feb 25.

Faculty of Medicine, University of Southampton, Southampton, UK.

Objective: To determine whether analysis of microvascular network perfusion using complexity-based methods can discriminate between groups of individuals at an increased risk of developing CVD.

Methods: Data were obtained from laser Doppler recordings of skin blood flux at the forearm in 50 participants with non-alcoholic fatty liver disease grouped for absence (n = 28) or presence (n = 14) of type 2 diabetes and use of calcium channel blocker medication (n = 8). Power spectral density was evaluated and Lempel-Ziv complexity determined to quantify signal information content at single and multiple time-scales to account for the different processes modulating network perfusion. Read More

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http://dx.doi.org/10.1111/micc.12538DOI Listing
February 2019

Effect of mild hypothermia on cerebral microcirculation in a murine cardiopulmonary resuscitation model.

Microcirculation 2019 Feb 23. Epub 2019 Feb 23.

Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.

Background: We hypothesized that mild hypothermia may improve brain microcirculation by reducing cerebral microvascular endothelial cells apoptosis, and this effect may be maximized by moving up the initiation of mild hypothermia from after return of spontaneous circulation (ROSC) to the start of cardiopulmonary resuscitation (CPR).

Methods: A total of 35 rats were randomized into the intra-arrest hypothermia group (IAH), post-resuscitation hypothermia group (PRH), normothermia group (NT), or the sham control group. A craniotomy exposed the parietal cortex for visualization of microcirculation. Read More

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http://dx.doi.org/10.1111/micc.12537DOI Listing
February 2019
1 Read
2.565 Impact Factor

Retinal microvascular changes in microvascular angina: Findings from the Australian Heart Eye Study.

Microcirculation 2019 Feb 13:e12536. Epub 2019 Feb 13.

Centre for Vision Research, The Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.

Objective: Microvascular changes in microvascular angina are poorly understood due to difficulties in imaging the coronary microcirculation in vivo. The retinal microvasculature may reflect changes in coronary microcirculation. We assessed microvascular changes in the retina in patients with microvascular angina and compared them with patients with angiographically proven coronary artery disease. Read More

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February 2019
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Transient receptor potential vanilloid 4 channels are important regulators of parenchymal arteriole dilation and cognitive function.

Microcirculation 2019 Feb 5:e12535. Epub 2019 Feb 5.

Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan.

Objective: Hypertension-associated PA dysfunction reduces cerebral perfusion and impairs cognition. This is associated with impaired TRPV4-mediated PA dilation; therefore, we tested the hypothesis that TRPV4 channels are important regulators of cerebral perfusion, PA structure and dilation, and cognition.

Methods: Ten- to twelve-month-old male TRPV4 knockout (WKY-Trpv4 ) and age-matched control WKY rats were studied. Read More

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http://dx.doi.org/10.1111/micc.12535DOI Listing
February 2019
4 Reads

Matrix metalloproteinase-9 mediated shedding of syndecan-4 in glomerular endothelial cells.

Microcirculation 2019 Jan 31:e12534. Epub 2019 Jan 31.

Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Background: Diabetic nephropathy is the most common cause of end-stage renal failure in the western world and Asia. The mechanisms are not fully elucidated, but disruption of glomerular endothelial glycocalyx and shedding of its components including syndecans has been implicated.

Aims: We hypothesize that reduced glomerular filtration in diabetes is caused by disruption of endothelial glycocalyx in glomeruli, including increased shedding of syndecan-4. Read More

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January 2019
1 Read

Microcirculation at Mooloolaba.

Authors:
Marianne Tare

Microcirculation 2019 02;26(2):e12533

Monash Rural Health, Monash University, Churchill, Victoria, Australia.

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February 2019

A streak length-based method for quantifying red blood cell flow in skeletal muscle arteriolar networks.

Microcirculation 2019 Jan 25:e12532. Epub 2019 Jan 25.

Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada.

Objective: To develop an experimental method to quantify RBC flow throughout skeletal muscle arteriolar networks.

Methods: Data on arteriolar geometry were obtained using IVVM of the rat GM. RBC velocities and number densities were also obtained during these experiments using fluorescently labeled RBCs. Read More

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http://dx.doi.org/10.1111/micc.12532DOI Listing
January 2019

Fractal characterization of retinal microvascular network morphology during diabetic retinopathy progression.

Microcirculation 2019 Jan 19:e12531. Epub 2019 Jan 19.

Faculty for Information Systems and Technologies, University of Donja Gorica, Podgorica, Montenegro.

Objective: The study aimed to characterize morphological changes of the retinal microvascular network during the progression of diabetic retinopathy.

Methods: Publicly available retinal images captured by a digital fundus camera from DIARETDB1 and STARE databases were used. The retinal microvessels were segmented using the automatic method, and vascular network morphology was analyzed by fractal parametrization such as box-counting dimension, lacunarity, and multifractals. Read More

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http://dx.doi.org/10.1111/micc.12531DOI Listing
January 2019
3 Reads

The presence of cerebral white matter lesions and lower skin microvascular perfusion predicts lower cognitive performance in type 1 diabetes patients with retinopathy but not in healthy controls-A longitudinal study.

Microcirculation 2019 Apr 22;26(3):e12530. Epub 2019 Feb 22.

Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Objective: Cognitive impairments in type 1 diabetes may result from hyperglycemia-associated cerebral microangiopathy. We aimed to identify cerebral microangiopathy and skin microvascular dysfunction-as a surrogate marker for generalized microvascular function-as predictors of cognitive performance over time.

Methods: In this prospective cohort study, 25 type 1 diabetes patients with proliferative retinopathy and 25 matched healthy controls underwent neurocognitive testing at baseline and after follow-up (3. Read More

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http://dx.doi.org/10.1111/micc.12530DOI Listing

Quantitative assessment of microperfusion by indocyanine green angiography in kidney transplantation resembles chronic morphological changes in kidney specimens.

Microcirculation 2019 Apr 8;26(3):e12529. Epub 2019 Feb 8.

Department of Surgery, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Objective: ICG fluorescence angiography enables a quantitative real-time perfusion assessment in kidney transplantation. The results of intraoperative microperfusion of the kidney allograft were compared to the renal chronicity score in pre-transplantation kidney biopsy specimens. The intrarenal resistance index was calculated by duplex sonography as a method of reference. Read More

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http://dx.doi.org/10.1111/micc.12529DOI Listing
April 2019
1 Read
2.565 Impact Factor

Quantification of adherens junction disruption and contiguous paracellular protein leak in human lung endothelial cells under septic conditions.

Microcirculation 2019 Apr 13;26(3):e12528. Epub 2019 Mar 13.

Centre for Critical Illness Research, Lawson Health Research Institute, London, ON, Canada.

Objective: Sepsis is associated with dysfunction of MVEC resulting in organ edema and inflammation. VE-cadherin, a component of MVEC adherens junctions, may be disrupted in sepsis. However, the direct connection between individual MVEC VE-cadherin disruption and increased paracellular permeability is uncertain. Read More

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April 2019
12 Reads

Developmental onset of cardiovascular disease-Could the proof be in the placenta?

Microcirculation 2018 Dec 29:e12526. Epub 2018 Dec 29.

Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey.

The Barker Hypothesis states change to the maternal environment may have significant impacts on fetal development, setting the stage for adult disease to occur. The development of the maternofetal vasculature during implantation and maintenance during pregnancy is extremely precise, yet dynamic. Delays or dysfunction in the orchestration of anatomical remodeling, maintenance of blood pressure, or responsiveness to metabolic demand may have severe consequences to the developing fetus. Read More

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http://dx.doi.org/10.1111/micc.12526DOI Listing
December 2018

Morphological and Pharmacological Characterization of the Porcine Popliteal Artery: A Novel Model for Study of Lower Limb Arterial Disease.

Microcirculation 2018 Dec 30:e12527. Epub 2018 Dec 30.

Department of Medical Physiology, College of Medicine, Texas A&M Health Science Center, Temple, TX, USA.

Objective: This study was undertaken to characterize structural and pharmacological properties of the pig popliteal artery in order to develop a novel system for the examination of lower limb blood flow regulation in a variety of cardiovascular pathologies, such as diabetes-induced peripheral artery disease.

Methods: Popliteal arteries were isolated from streptozocin-induced diabetic pigs or age-matched saline-injected control pigs for morphological study using transmission electron microscopy and for examination of vasoreactivity to pharmacological agents using wire myography.

Results: Transmission electron microscopy of the porcine popliteal artery wall revealed the presence of endothelial cell-smooth muscle cell interactions (myoendothelial junctions) and smooth muscle cell-smooth muscle cell interactions, for which we have coined the term "myo-myo junctions. Read More

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December 2018

Dietary nitrate improves muscle microvascular reactivity and lowers blood pressure at rest and during isometric exercise in untreated hypertensives.

Microcirculation 2019 Apr 11;26(3):e12525. Epub 2019 Jan 11.

Third Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Objective: This double-blind, cross-over study examined in drug-naïve hypertensives the effects of a single dose of dietary nitrate (beetroot juice, BRJ) on (a) office/ambulatory BP and arterial stiffness, (b) muscle microvascular function, and (c) hemodynamic responses and cardiovagal baroreceptor sensitivity (cBRS) at rest and during isometric exercise.

Methods: Eighteen untreated hypertensives (44.0 ± 2. Read More

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http://dx.doi.org/10.1111/micc.12525DOI Listing

The effect of elective implantation of the ABSORB bioresorbable vascular scaffold on coronary microcirculation: Serial assessment using the index of microcirculatory resistance.

Microcirculation 2019 Apr 9;26(3):e12521. Epub 2019 Jan 9.

Sussex Cardiac Centre, Brighton and Sussex University Hospitals, Brighton, UK.

Introduction: Stenting with metal stents can affect microcirculatory function. The impact of BVS on the microvascular network has not been studied.

Methods: A total of 30 patients with bifurcation disease of Medina (X,X,0) scheduled for elective PCI with the ABSORB BVS were studied. Read More

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http://doi.wiley.com/10.1111/micc.12521
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April 2019
10 Reads

Transilluminated powered phlebectomy in the treatment of large area venous leg ulcers: A case-control study with 3 years follow-up.

Microcirculation 2019 Apr 30;26(3):e12523. Epub 2019 Jan 30.

Department of Vascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: To evaluate the efficacy, safety and long-term outcome of TIPP for the adjunct therapy of superficial venous reflux-related VLUs.

Methods: A total of 93 consecutive patients (104 legs) with superficial venous insufficiency-related VLUs who underwent TIPP (53 legs) or conventional phlebectomy (51 legs) between January 2010 and December 2013 were retrospectively studied.

Results: Compared to patients in the conventional phlebectomy group, TIPP patients had larger ulcer areas before surgery (P < 0. Read More

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http://dx.doi.org/10.1111/micc.12523DOI Listing

Targeting the vascular dysfunction: Potential treatments for preeclampsia.

Microcirculation 2018 Dec 16:e12522. Epub 2018 Dec 16.

Departments of Obstetrics and Gynaecology and Medicine, School of Clinical Sciences, The Ritchie Centre, Monash University, Clayton, Victoria, Australia.

Preeclampsia is a pregnancy-specific disorder, primarily characterized by new-onset hypertension in combination with a variety of other maternal or fetal signs. The pathophysiological mechanisms underlying the disease are still not entirely clear. Systemic maternal vascular dysfunction underlies the clinical features of preeclampsia. Read More

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http://dx.doi.org/10.1111/micc.12522DOI Listing
December 2018

Methods to label, image, and analyze the complex structural architectures of microvascular networks.

Microcirculation 2018 Dec 12:e12520. Epub 2018 Dec 12.

Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.

Microvascular networks play key roles in oxygen transport and nutrient delivery to meet the varied and dynamic metabolic needs of different tissues throughout the body, and their spatial architectures of interconnected blood vessel segments are highly complex. Moreover, functional adaptations of the microcirculation enabled by structural adaptations in microvascular network architecture are required for development, wound healing, and often invoked in disease conditions, including the top eight causes of death in the Unites States. Effective characterization of microvascular network architectures is not only limited by the available techniques to visualize microvessels but also reliant on the available quantitative metrics that accurately delineate between spatial patterns in altered networks. Read More

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http://dx.doi.org/10.1111/micc.12520DOI Listing
December 2018

High salt diet impairs cerebral blood flow regulation via salt-induced angiotensin II suppression.

Microcirculation 2019 Apr 15;26(3):e12518. Epub 2019 Jan 15.

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Objectives: This study sought to determine whether salt-induced ANG II suppression contributes to impaired CBF autoregulation.

Methods: Cerebral autoregulation was evaluated with LDF during graded reductions of blood pressure. Autoregulatory responses in rats fed HS (4% NaCl) diet vs LS (0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465152PMC
April 2019
13 Reads

Multifractal and lacunarity analyses of microvascular morphology in eyes with diabetic retinopathy: A projection artifact resolved optical coherence tomography angiography study.

Microcirculation 2019 Apr 20;26(3):e12519. Epub 2019 Mar 20.

Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China.

Objective: To evaluate the degree of microvascular impairment in DR using multifractal and lacunarity analyses and to compare the diagnostic ability between traditional Euclidean measures (fovea avascular zone area and vessel density) and fractal geometric features.

Methods: This retrospective cross-sectional study included a total of 143 eyes of 94 patients with different stages of DR. The retinal microvasculature was imaged by projection removed OCTA. Read More

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http://doi.wiley.com/10.1111/micc.12519
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April 2019
15 Reads

Skeletal muscle performance in metabolic disease: Microvascular or mitochondrial limitation or both?

Microcirculation 2018 Nov 24:e12517. Epub 2018 Nov 24.

Department of Physiology, Michigan State University, East Lansing, Michigan.

One of the clearly established health outcomes associated with chronic metabolic diseases (eg, type II diabetes mellitus) is that the ability of skeletal muscle to maintain contractile performance during periods of elevated metabolic demand is compromised as compared to the fatigue-resistance of muscle under normal, healthy conditions. While there has been extensive effort dedicated to determining the major factors that contribute to the compromised performance of skeletal muscle with chronic metabolic disease, the extent to which this poor outcome reflects a dysfunctional state of the microcirculation, where the delivery and distribution of metabolic substrates can be impaired, versus derangements to normal metabolic processes and mitochondrial function, versus a combination of the two, represents an area of considerable unknown. The purpose of this manuscript is to present some of the current concepts for dysfunction to both the microcirculation of skeletal muscle as well as to mitochondrial metabolism under these conditions, such that these diverse issues can be merged into an integrated framework for future investigation. Read More

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November 2018
13 Reads

Effects of tumor necrosis factor-α-induced exosomes on the endothelial cellular behavior, metabolism and bioenergetics.

Microcirculation 2019 01 29;26(1):e12515. Epub 2018 Nov 29.

Key Laboratory of Microcirculation, Ministry of Health, Institute of Microcirculation, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing, China.

Objective: To investigate the effects of TNF-α-induced exosomes release on the biological behavior, metabolism, and bioenergetics of HUVECs.

Methods: Exosomes were isolated from conditioned media of HUVECs by ultracentrifugation after treatment with or without TNF-α. HUVECs were treated with or without TNF-α, or different concentrations of exosomes isolated from conditioned media with or without TNF-α induction (T and C , respectively). Read More

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http://doi.wiley.com/10.1111/micc.12515
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January 2019
7 Reads

Capillary flow disturbances after experimental subarachnoid hemorrhage: A contributor to delayed cerebral ischemia?

Microcirculation 2019 Apr 7;26(3):e12516. Epub 2019 Mar 7.

Department of Clinical Medicine, Center of Functionally Integrative Neuroscience (CFIN), Aarhus University, Aarhus, Denmark.

Background: The high mortality and morbidity after SAH is partly due to DCI, which is traditionally ascribed to development of angiographic vasospasms. This relation has been challenged, and capillary flow disturbances are proposed as another mechanism contributing to brain damage after SAH.

Objective: To investigate capillary flow changes 4 days following experimental SAH. Read More

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http://dx.doi.org/10.1111/micc.12516DOI Listing
April 2019
1 Read

Impaired microvascular reactivity in gestational diabetes is associated with altered glycemic parameters.

Microcirculation 2019 01 7;26(1):e12513. Epub 2018 Dec 7.

Pharmacology Vascular Laboratory, Universiti Sains Malaysia, Kota Bharu, Malaysia.

Objectives: To assess microvascular reactivity and glycemic parameters in GDM compared to age and GA matched controls.

Methods: This study involved 21 GDM patients and 31 controls. Microvascular reactivity was assessed using LDF and PORH. Read More

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http://dx.doi.org/10.1111/micc.12513DOI Listing
January 2019
2 Reads

Urinary albumin excretion in rheumatoid arthritis is not associated with markers of vasculopathy in distal microvascular beds.

Microcirculation 2019 01 4;26(1):e12514. Epub 2018 Dec 4.

3rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Objective: Increased UAE is a marker of generalized vascular damage in high-cardiovascular risk patients. However, it remains unknown whether it corresponds to a state of diffuse vasculopathy in high-risk patients with RA.

Methods: UAE was estimated in 24-hour urine samples in RA and non-RA individuals. Read More

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http://doi.wiley.com/10.1111/micc.12514
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http://dx.doi.org/10.1111/micc.12514DOI Listing
January 2019
15 Reads

In vitro model reveals a role for mechanical stretch in the remodeling response of lymphatic muscle cells.

Microcirculation 2019 01 29;26(1):e12512. Epub 2018 Nov 29.

Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.

Objective: Using primary LMCs in vitro, we sought to characterize the impact of LMC remodeling on their functional and molecular response to mechanical loading and culture conditions.

Methods: Primary "wounded leg" LMCs were derived from the hindlimb of three sheep who underwent lymphatic injury 6 weeks prior, while "control leg" LMCs were derived from the contralateral, unwounded, limb. Function of the LMCs was characterized in response to media of variable levels of serum (10% vs 0. Read More

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http://doi.wiley.com/10.1111/micc.12512
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335159PMC
January 2019
1 Read

The role of α2-adrenergic receptors in hypertensive preeclampsia: A hypothesis.

Microcirculation 2019 01 27;26(1):e12511. Epub 2018 Nov 27.

Department of Pharmacology and Toxicology, American University of Beirut, Beirut, Lebanon.

Preeclampsia, a major disorder of human pregnancy, manifests as persistent hypertension and proteinuria presenting after 20 weeks of pregnancy. Multiple systemic symptoms might be associated with preeclampsia including thrombocytopenia, liver impairment, pulmonary edema, and cerebral disturbances. However, vascular dysfunction remains the core pathological driver of preeclampsia. Read More

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http://doi.wiley.com/10.1111/micc.12511
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January 2019
13 Reads

Von Willebrand factor contribution to pathophysiology outside of von Willebrand disease.

Microcirculation 2018 Oct 26:e12510. Epub 2018 Oct 26.

Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

VWF is a procoagulant protein that plays a central role in the initiation of platelets aggregate formation and thrombosis. While von Willebrand disease has long been known to result from qualitative and quantitative deficiencies of VWF, it is recently that contribution of elevated levels of VWF to various pathological conditions including thrombosis, inflammation, angiogenesis, and cancer metastasis has been appreciated. Here, we discuss contribution of elevated levels of VWF to various thrombotic and nonthrombotic pathological conditions. Read More

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http://doi.wiley.com/10.1111/micc.12510
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October 2018
26 Reads

Subclinical myocardial dysfunction in coronary slow flow phenomenon: Identification by speckle tracking echocardiography.

Microcirculation 2019 01 27;26(1):e12509. Epub 2018 Nov 27.

Department of Echocardiography, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Shanghai Institute of Medical Imaging, Fudan University, Shanghai, China.

Objective: This study aimed to determine whether STE could help detect subclinical myocardial dysfunction in patients with CSFP.

Methods: Sixty patients with CSFP confirmed by CAG and 51 controls with normal coronary flow were prospectively enrolled. Coronary angiographic data and conventional and speckle tracking echocardiographic parameters of the LV and RV were obtained for every subject. Read More

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http://doi.wiley.com/10.1111/micc.12509
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January 2019
12 Reads
2.565 Impact Factor

Molecular determinants of microvascular dysfunction in hypertensive pregnancy and preeclampsia.

Microcirculation 2018 Oct 19:e12508. Epub 2018 Oct 19.

Vascular Surgery Research Laboratories, Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Preeclampsia is a pregnancy-related disorder characterized by hypertension and often fetal intrauterine growth restriction, but the underlying mechanisms are unclear. Defective placentation and apoptosis of invasive cytotrophoblasts cause inadequate remodeling of spiral arteries, placental ischemia, and reduced uterine perfusion pressure (RUPP). RUPP causes imbalance between the anti-angiogenic factors soluble fms-like tyrosine kinase-1 and soluble endoglin and the pro-angiogenic vascular endothelial growth factor and placental growth factor, and stimulates the release of proinflammatory cytokines, hypoxia-inducible factor, reactive oxygen species, and angiotensin AT receptor agonistic autoantibodies. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474836PMC
October 2018
10 Reads

Sphingosine-1-phosphate protects against brain microvascular endothelial junctional protein disorganization and barrier dysfunction caused by alcohol.

Microcirculation 2019 01 17;26(1):e12506. Epub 2018 Oct 17.

Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.

Objective: S1P has known endothelial barrier-protective properties, but whether this extends to the BBB is unclear. We hypothesized that alcohol-induced disruption of brain microvascular endothelial barrier function and junctional protein organization can be ameliorated by S1P treatment.

Methods: Cultured primary HBMEC monolayers were used to characterize endothelial-specific mechanisms of BBB regulation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335152PMC
January 2019

Microvascular circulatory dysregulation driven in part by cystathionine gamma-lyase: A new paradigm for cardiovascular compromise in the preterm newborn.

Microcirculation 2019 02 30;26(2):e12507. Epub 2018 Oct 30.

Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.

Objective: H S may explain the dysregulation of microvascular tone associated with poor outcome following preterm birth. In adult vasculature, H S is predominantly produced by CSE. We hypothesized that vascular CSE activity contributes to microvascular tone regulation during circulatory transition. Read More

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February 2019
5 Reads

Relationship between the endothelial glycocalyx and the extent of coronary atherosclerosis.

Microcirculation 2018 11 8;25(8):e12504. Epub 2018 Oct 8.

Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Objective: To investigate the correlation between the EG and the severity of coronary atherosclerosis.

Methods: A total of193 subjects were divided into two groups. A SDF video microscope with a glycocalyx thickness measurement system was used to visualize the sublingual microcirculation. Read More

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November 2018
4 Reads

A new complimentary web-based tool for manual analysis of microcirculation videos: Validation of the Capillary Mapper against the current gold standard AVA 3.2.

Microcirculation 2018 11 8;25(8):e12505. Epub 2018 Oct 8.

Department of Anesthesiology, Intensive Care and Pain Therapy, University of Muenster Medical Centre, Muenster, Germany.

Objective: The aim of the current study was to compare a newly developed web-based freely accessible software program for manual analysis of the microcirculation, the Capillary Mapper (CM), with AVA 3.2 software (AVA; MicroVision Medical B.V. Read More

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http://doi.wiley.com/10.1111/micc.12505
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http://dx.doi.org/10.1111/micc.12505DOI Listing
November 2018
30 Reads

The protective effect of betulinic acid on microvascular responsivity and protein expression in alzheimer disease induced by cerebral micro-injection of beta-amyloid and streptozotocin.

Microcirculation 2018 11 8;25(8):e12503. Epub 2018 Oct 8.

Department of Physiology, Faculty of Medicine, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective: Alzheimer's disease (AD) is mainly caused by accumulation of β-amyloid (Aβ) in vessels or parenchyma of the brain. Accordingly, natural compounds such as betulinic acid (BA) might improve the AD signs by increase in blood flow and through reduction in amyloid plaques.

Methods: Intra-hippocampal injection of BA (0. Read More

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November 2018
3 Reads

Induction of microvascular network growth in the mouse mesentery.

Microcirculation 2018 11 10;25(8):e12502. Epub 2018 Oct 10.

Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana.

Objective: Motivated by observations of mesenteries harvested from mice treated with tamoxifen dissolved in oil for inducible gene mutation studies, the objective of this study was to demonstrate that microvascular growth can be induced in the avascular mouse mesentery tissue.

Methods: C57BL/6 mice were administered an IP injection for five consecutive days of: saline, sunflower oil, tamoxifen dissolved in sunflower oil, corn oil, or peanut oil.

Results: Twenty-one days post-injection, zero tissues from saline group contained branching microvascular networks. Read More

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http://doi.wiley.com/10.1111/micc.12502
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http://dx.doi.org/10.1111/micc.12502DOI Listing
November 2018
9 Reads

Modified redox signaling in vasculature after chronic infusion of the insulin receptor antagonist, S961.

Microcirculation 2019 02 10;26(2):e12501. Epub 2018 Oct 10.

Cardiovascular and Thoracic Health, Kolling Institute of Medical Research, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

Background: Type 2 diabetes and associated vascular complications cause substantial morbidity and mortality. It is important to investigate mechanisms and test therapies in relevant physiological models, yet few animal models adequately recapitulate all aspects of the human condition.

Objective: We sought to determine the potential of using an insulin receptor antagonist, S961, in mice for investigating vascular pathophysiology. Read More

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February 2019
1 Read

Variation of endothelium-related hemostatic factors during sepsis.

Microcirculation 2018 11 10;25(8):e12500. Epub 2018 Oct 10.

Intensive Care Unit, 1st Department of Respiratory Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Objective: The thrombomodulin/protein C and VWF/ADAMTS-13 pathways are disturbed in sepsis and have been implicated in the coagulation disorders that characterize the septic syndrome. We aimed to assess the variation of these endothelial parameters during sepsis and their putative association with outcome, in critically ill, septic patients.

Methods: We monitored 34 septic patients, 23 of whom improved (group A) while 11 deteriorated (group B). Read More

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http://dx.doi.org/10.1111/micc.12500DOI Listing
November 2018
9 Reads

LncRNA-FENDRR mediates VEGFA to promote the apoptosis of brain microvascular endothelial cells via regulating miR-126 in mice with hypertensive intracerebral hemorrhage.

Microcirculation 2018 11 10;25(8):e12499. Epub 2018 Oct 10.

Department of Neurosurgery, The Fourth Affiliated Hospital of Baotou Medical College, Baotou Eighth Hospital, Baotou, China.

Background: LncRNA-FENDRR is a kind of endothelial genes critical for vascular development. Moreover, miR-126 and vascular endothelial growth factor A (VEGFA) are also involved in the physiological process of vascular endothelial cells. This study aimed to the underlying mechanism of FENDRR involving miR-126 and VEGFA in hypertensive intracerebral hemorrhage (HICH). Read More

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http://doi.wiley.com/10.1111/micc.12499
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November 2018
29 Reads

Mast cells and primary systemic vasculitides.

Microcirculation 2018 11 12;25(8):e12498. Epub 2018 Sep 12.

Department of Medicine, Human Anatomy Section, University of Udine Medical School, Udine, Italy.

Vasculitides are characterized by inflammation and necrosis of blood vessels leading to vessel occlusion and ischemic damages of tissues. Among the inflammatory cells involved in vasculitides, neutrophils, T cells, and macrophages have been identified as the predominant cell type. This review article is focused on the role of mast cells in these chronic inflammatory processes. Read More

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November 2018
3 Reads