1,325 results match your criteria Microcirculation [Journal]


Retinal Microvascular Changes in Microvascular Angina: Findings from the Australian Heart Eye Study.

Microcirculation 2019 Feb 13:e12536. Epub 2019 Feb 13.

Centre for Vision Research, The Westmead Institute for Medical Research, University of Sydney, NSW, Australia.

Objective: Microvascular changes in microvascular angina are poorly understood due to difficulties in imaging the coronary microcirculation in vivo. The retinal microvasculature may reflect changes in coronary microcirculation. We assessed microvascular changes in the retina in patients with microvascular angina and compared them with patients with angiographically proven coronary artery disease. Read More

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February 2019

Transient receptor potential vanilloid 4 channels are important regulators of parenchymal arteriole dilation and cognitive function.

Microcirculation 2019 Feb 5:e12535. Epub 2019 Feb 5.

Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan.

Objective: Hypertension-associated PA dysfunction reduces cerebral perfusion and impairs cognition. This is associated with impaired TRPV4-mediated PA dilation; therefore, we tested the hypothesis that TRPV4 channels are important regulators of cerebral perfusion, PA structure and dilation, and cognition.

Methods: Ten- to twelve-month-old male TRPV4 knockout (WKY-Trpv4 ) and age-matched control WKY rats were studied. Read More

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February 2019
2 Reads

Matrix metalloproteinase-9 mediated shedding of syndecan-4 in glomerular endothelial cells.

Microcirculation 2019 Jan 31:e12534. Epub 2019 Jan 31.

Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Background: Diabetic nephropathy is the most common cause of end-stage renal failure in the western world and Asia. The mechanisms are not fully elucidated, but disruption of glomerular endothelial glycocalyx and shedding of its components including syndecans has been implicated.

Aims: We hypothesize that reduced glomerular filtration in diabetes is caused by disruption of endothelial glycocalyx in glomeruli, including increased shedding of syndecan-4. Read More

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January 2019
1 Read

Microcirculation at Mooloolaba.

Authors:
Marianne Tare

Microcirculation 2019 Feb;26(2):e12533

Monash Rural Health, Monash University, Churchill, Victoria, Australia.

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February 2019

A streak length-based method for quantifying red blood cell flow in skeletal muscle arteriolar networks.

Microcirculation 2019 Jan 25:e12532. Epub 2019 Jan 25.

Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada.

Objective: To develop an experimental method to quantify RBC flow throughout skeletal muscle arteriolar networks.

Methods: Data on arteriolar geometry were obtained using IVVM of the rat GM. RBC velocities and number densities were also obtained during these experiments using fluorescently labeled RBCs. Read More

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http://dx.doi.org/10.1111/micc.12532DOI Listing
January 2019

Fractal characterization of retinal microvascular network morphology during diabetic retinopathy progression.

Microcirculation 2019 Jan 19:e12531. Epub 2019 Jan 19.

Faculty for Information Systems and Technologies, University of Donja Gorica, Podgorica, Montenegro.

Objective: The study aimed to characterize morphological changes of the retinal microvascular network during the progression of diabetic retinopathy.

Methods: Publicly available retinal images captured by a digital fundus camera from DIARETDB1 and STARE databases were used. The retinal microvessels were segmented using the automatic method, and vascular network morphology was analyzed by fractal parametrization such as box-counting dimension, lacunarity, and multifractals. Read More

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January 2019
2 Reads

The presence of cerebral white matter lesions and lower skin microvascular perfusion predicts lower cognitive performance in type 1 diabetes patients with retinopathy but not in healthy controls-A longitudinal study.

Microcirculation 2019 Jan 19:e12530. Epub 2019 Jan 19.

Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Objective: Cognitive impairments in type 1 diabetes may result from hyperglycemia-associated cerebral microangiopathy. We aimed to identify cerebral microangiopathy and skin microvascular dysfunction-as a surrogate marker for generalized microvascular function-as predictors of cognitive performance over time.

Methods: In this prospective cohort study, 25 type 1 diabetes patients with proliferative retinopathy and 25 matched healthy controls underwent neurocognitive testing at baseline and after follow-up (3. Read More

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January 2019

Quantitative assessment of microperfusion by indocyanine green angiography in kidney transplantation resembles chronic morphological changes in kidney specimens.

Microcirculation 2019 Jan 17:e12529. Epub 2019 Jan 17.

Department of Surgery, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Objective: ICG fluorescence angiography enables a quantitative real-time perfusion assessment in kidney transplantation. The results of intraoperative microperfusion of the kidney allograft were compared to the renal chronicity score in pre-transplantation kidney biopsy specimens. The intrarenal resistance index was calculated by duplex sonography as a method of reference. Read More

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January 2019
2.565 Impact Factor

Quantification of adherens junction disruption and contiguous paracellular protein leak in human lung endothelial cells under septic conditions.

Microcirculation 2019 Jan 12:e12528. Epub 2019 Jan 12.

Centre for Critical Illness Research, Lawson Health Research Institute, London, ON, Canada.

Objective: Sepsis is associated with dysfunction of microvascular endothelial cells (MVEC) resulting in organ edema and inflammation. Vascular endothelial (VE)-cadherin, a component of MVEC adherens junctions, may be disrupted in sepsis. However, the direct connection between individual MVEC VE-cadherin disruption and increased paracellular permeability is uncertain. Read More

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January 2019
8 Reads

Developmental onset of cardiovascular disease-Could the proof be in the placenta?

Microcirculation 2018 Dec 29:e12526. Epub 2018 Dec 29.

Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey.

The Barker Hypothesis states change to the maternal environment may have significant impacts on fetal development, setting the stage for adult disease to occur. The development of the maternofetal vasculature during implantation and maintenance during pregnancy is extremely precise, yet dynamic. Delays or dysfunction in the orchestration of anatomical remodeling, maintenance of blood pressure, or responsiveness to metabolic demand may have severe consequences to the developing fetus. Read More

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December 2018

Morphological and Pharmacological Characterization of the Porcine Popliteal Artery: A Novel Model for Study of Lower Limb Arterial Disease.

Microcirculation 2018 Dec 30:e12527. Epub 2018 Dec 30.

Department of Medical Physiology, College of Medicine, Texas A&M Health Science Center, Temple, TX, USA.

Objective: This study was undertaken to characterize structural and pharmacological properties of the pig popliteal artery in order to develop a novel system for the examination of lower limb blood flow regulation in a variety of cardiovascular pathologies, such as diabetes-induced peripheral artery disease.

Methods: Popliteal arteries were isolated from streptozocin-induced diabetic pigs or age-matched saline-injected control pigs for morphological study using transmission electron microscopy and for examination of vasoreactivity to pharmacological agents using wire myography.

Results: Transmission electron microscopy of the porcine popliteal artery wall revealed the presence of endothelial cell-smooth muscle cell interactions (myoendothelial junctions) and smooth muscle cell-smooth muscle cell interactions, for which we have coined the term "myo-myo junctions. Read More

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December 2018

Dietary nitrate improves muscle microvascular reactivity and lowers blood pressure at rest and during isometric exercise in untreated hypertensives.

Microcirculation 2018 Dec 26:e12525. Epub 2018 Dec 26.

Third Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Objective: This double-blind, cross-over study examined in drug-naïve hypertensives the effects of a single dose of dietary nitrate (beetroot juice, BRJ) on (a) office/ambulatory BP and arterial stiffness, (b) muscle microvascular function, and (c) hemodynamic responses and cardiovagal baroreceptor sensitivity (cBRS) at rest and during isometric exercise.

Methods: Eighteen untreated hypertensives (44.0 ± 2. Read More

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http://dx.doi.org/10.1111/micc.12525DOI Listing
December 2018

The effect of elective implantation of the ABSORB bioresorbable vascular scaffold on coronary microcirculation: Serial assessment using the index of microcirculatory resistance.

Microcirculation 2018 Dec 18:e12521. Epub 2018 Dec 18.

Sussex Cardiac Centre, Brighton and Sussex University Hospitals, Brighton, UK.

Introduction: Stenting with metal stents can affect microcirculatory function. The impact of BVS on the microvascular network has not been studied.

Methods: A total of 30 patients with bifurcation disease of Medina (X,X,0) scheduled for elective PCI with the ABSORB BVS were studied. Read More

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http://doi.wiley.com/10.1111/micc.12521
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December 2018
3 Reads

Transilluminated powered phlebectomy in the treatment of large area venous leg ulcers: A case-control study with 3 years follow-up.

Microcirculation 2018 Dec 16:e12523. Epub 2018 Dec 16.

Department of Vascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: To evaluate the efficacy, safety and long-term outcome of TIPP for the adjunct therapy of superficial venous reflux-related VLUs.

Methods: A total of 93 consecutive patients (104 legs) with superficial venous insufficiency-related VLUs who underwent TIPP (53 legs) or conventional phlebectomy (51 legs) between January 2010 and December 2013 were retrospectively studied.

Results: Compared to patients in the conventional phlebectomy group, TIPP patients had larger ulcer areas before surgery (P < 0. Read More

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http://dx.doi.org/10.1111/micc.12523DOI Listing
December 2018

Targeting the vascular dysfunction: Potential treatments for preeclampsia.

Microcirculation 2018 Dec 16:e12522. Epub 2018 Dec 16.

Departments of Obstetrics and Gynaecology and Medicine, School of Clinical Sciences, The Ritchie Centre, Monash University, Clayton, Victoria, Australia.

Preeclampsia is a pregnancy-specific disorder, primarily characterized by new-onset hypertension in combination with a variety of other maternal or fetal signs. The pathophysiological mechanisms underlying the disease are still not entirely clear. Systemic maternal vascular dysfunction underlies the clinical features of preeclampsia. Read More

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http://dx.doi.org/10.1111/micc.12522DOI Listing
December 2018

Methods to label, image, and analyze the complex structural architectures of microvascular networks.

Microcirculation 2018 Dec 12:e12520. Epub 2018 Dec 12.

Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.

Microvascular networks play key roles in oxygen transport and nutrient delivery to meet the varied and dynamic metabolic needs of different tissues throughout the body, and their spatial architectures of interconnected blood vessel segments are highly complex. Moreover, functional adaptations of the microcirculation enabled by structural adaptations in microvascular network architecture are required for development, wound healing, and often invoked in disease conditions, including the top eight causes of death in the Unites States. Effective characterization of microvascular network architectures is not only limited by the available techniques to visualize microvessels but also reliant on the available quantitative metrics that accurately delineate between spatial patterns in altered networks. Read More

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http://dx.doi.org/10.1111/micc.12520DOI Listing
December 2018

High salt diet impairs cerebral blood flow regulation via salt-induced angiotensin II suppression.

Microcirculation 2018 Nov 27:e12518. Epub 2018 Nov 27.

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Objectives: This study sought to determine whether salt-induced ANG II suppression contributes to impaired CBF autoregulation.

Methods: Cerebral autoregulation was evaluated with LDF during graded reductions of blood pressure. Autoregulatory responses in rats fed HS (4% NaCl) diet vs LS (0. Read More

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http://doi.wiley.com/10.1111/micc.12518
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November 2018
9 Reads

Multifractal and Lacunarity Analyses of Microvascular Morphology in Eyes with Diabetic Retinopathy: A Projection Artifact Resolved Optical Coherence Tomography Angiography Study.

Microcirculation 2018 Nov 27:e12519. Epub 2018 Nov 27.

Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China.

Objective: To evaluate the degree of microvascular impairment in diabetic retinopathy using multifractal and lacunarity analyses and to compare the diagnostic ability between traditional Euclidean measures (fovea avascular zone area and vessel density) and fractal geometric features.

Methods: This retrospective cross-sectional study included a total of 143 eyes of 94 patients with different stages of diabetic retinopathy. The retinal microvasculature was imaged by projection removed optical coherence tomography angiography. Read More

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http://doi.wiley.com/10.1111/micc.12519
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November 2018
11 Reads

Skeletal muscle performance in metabolic disease: Microvascular or mitochondrial limitation or both?

Microcirculation 2018 Nov 24:e12517. Epub 2018 Nov 24.

Department of Physiology, Michigan State University, East Lansing, Michigan.

One of the clearly established health outcomes associated with chronic metabolic diseases (eg, type II diabetes mellitus) is that the ability of skeletal muscle to maintain contractile performance during periods of elevated metabolic demand is compromised as compared to the fatigue-resistance of muscle under normal, healthy conditions. While there has been extensive effort dedicated to determining the major factors that contribute to the compromised performance of skeletal muscle with chronic metabolic disease, the extent to which this poor outcome reflects a dysfunctional state of the microcirculation, where the delivery and distribution of metabolic substrates can be impaired, versus derangements to normal metabolic processes and mitochondrial function, versus a combination of the two, represents an area of considerable unknown. The purpose of this manuscript is to present some of the current concepts for dysfunction to both the microcirculation of skeletal muscle as well as to mitochondrial metabolism under these conditions, such that these diverse issues can be merged into an integrated framework for future investigation. Read More

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November 2018
8 Reads

Effects of tumor necrosis factor-α-induced exosomes on the endothelial cellular behavior, metabolism and bioenergetics.

Microcirculation 2019 Jan 29;26(1):e12515. Epub 2018 Nov 29.

Key Laboratory of Microcirculation, Ministry of Health, Institute of Microcirculation, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing, China.

Objective: To investigate the effects of TNF-α-induced exosomes release on the biological behavior, metabolism, and bioenergetics of HUVECs.

Methods: Exosomes were isolated from conditioned media of HUVECs by ultracentrifugation after treatment with or without TNF-α. HUVECs were treated with or without TNF-α, or different concentrations of exosomes isolated from conditioned media with or without TNF-α induction (T and C , respectively). Read More

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http://doi.wiley.com/10.1111/micc.12515
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January 2019
7 Reads

Capillary flow disturbances after experimental subarachnoid hemorrhage: a contributor to delayed cerebral ischemia?

Microcirculation 2018 Nov 15:e12516. Epub 2018 Nov 15.

Center of Functionally Integrative Neuroscience (CFIN) Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Background: The high mortality and morbidity after subarachnoid hemorrhage (SAH) is partly due to delayed cerebral ischemia, which is traditionally ascribed to development of angiographic vasospasms. This relation has been challenged, and capillary flow disturbances are proposed as another mechanism contributing to brain damage after SAH.

Objective: To investigate capillary flow changes four days following experimental SAH. Read More

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November 2018
1 Read

Impaired microvascular reactivity in gestational diabetes is associated with altered glycemic parameters.

Microcirculation 2019 Jan 7;26(1):e12513. Epub 2018 Dec 7.

Pharmacology Vascular Laboratory, Universiti Sains Malaysia, Kota Bharu, Malaysia.

Objectives: To assess microvascular reactivity and glycemic parameters in GDM compared to age and GA matched controls.

Methods: This study involved 21 GDM patients and 31 controls. Microvascular reactivity was assessed using LDF and PORH. Read More

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http://dx.doi.org/10.1111/micc.12513DOI Listing
January 2019
2 Reads

Urinary albumin excretion in rheumatoid arthritis is not associated with markers of vasculopathy in distal microvascular beds.

Microcirculation 2019 Jan 4;26(1):e12514. Epub 2018 Dec 4.

3rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Objective: Increased UAE is a marker of generalized vascular damage in high-cardiovascular risk patients. However, it remains unknown whether it corresponds to a state of diffuse vasculopathy in high-risk patients with RA.

Methods: UAE was estimated in 24-hour urine samples in RA and non-RA individuals. Read More

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http://doi.wiley.com/10.1111/micc.12514
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January 2019
10 Reads

In vitro model reveals a role for mechanical stretch in the remodeling response of lymphatic muscle cells.

Microcirculation 2019 Jan 29;26(1):e12512. Epub 2018 Nov 29.

Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.

Objective: Using primary LMCs in vitro, we sought to characterize the impact of LMC remodeling on their functional and molecular response to mechanical loading and culture conditions.

Methods: Primary "wounded leg" LMCs were derived from the hindlimb of three sheep who underwent lymphatic injury 6 weeks prior, while "control leg" LMCs were derived from the contralateral, unwounded, limb. Function of the LMCs was characterized in response to media of variable levels of serum (10% vs 0. Read More

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http://doi.wiley.com/10.1111/micc.12512
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335159PMC
January 2019
1 Read

The role of α2-adrenergic receptors in hypertensive preeclampsia: A hypothesis.

Microcirculation 2019 Jan 27;26(1):e12511. Epub 2018 Nov 27.

Department of Pharmacology and Toxicology, American University of Beirut, Beirut, Lebanon.

Preeclampsia, a major disorder of human pregnancy, manifests as persistent hypertension and proteinuria presenting after 20 weeks of pregnancy. Multiple systemic symptoms might be associated with preeclampsia including thrombocytopenia, liver impairment, pulmonary edema, and cerebral disturbances. However, vascular dysfunction remains the core pathological driver of preeclampsia. Read More

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http://doi.wiley.com/10.1111/micc.12511
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January 2019
7 Reads

Von Willebrand factor contribution to pathophysiology outside of von Willebrand disease.

Microcirculation 2018 Oct 26:e12510. Epub 2018 Oct 26.

Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

VWF is a procoagulant protein that plays a central role in the initiation of platelets aggregate formation and thrombosis. While von Willebrand disease has long been known to result from qualitative and quantitative deficiencies of VWF, it is recently that contribution of elevated levels of VWF to various pathological conditions including thrombosis, inflammation, angiogenesis, and cancer metastasis has been appreciated. Here, we discuss contribution of elevated levels of VWF to various thrombotic and nonthrombotic pathological conditions. Read More

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October 2018
22 Reads

Subclinical myocardial dysfunction in coronary slow flow phenomenon: Identification by speckle tracking echocardiography.

Microcirculation 2019 Jan 27;26(1):e12509. Epub 2018 Nov 27.

Department of Echocardiography, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Shanghai Institute of Medical Imaging, Fudan University, Shanghai, China.

Objective: This study aimed to determine whether STE could help detect subclinical myocardial dysfunction in patients with CSFP.

Methods: Sixty patients with CSFP confirmed by CAG and 51 controls with normal coronary flow were prospectively enrolled. Coronary angiographic data and conventional and speckle tracking echocardiographic parameters of the LV and RV were obtained for every subject. Read More

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http://doi.wiley.com/10.1111/micc.12509
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January 2019
8 Reads
2.565 Impact Factor

Molecular determinants of microvascular dysfunction in hypertensive pregnancy and preeclampsia.

Microcirculation 2018 Oct 19:e12508. Epub 2018 Oct 19.

Vascular Surgery Research Laboratories, Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Preeclampsia is a pregnancy-related disorder characterized by hypertension and often fetal intrauterine growth restriction, but the underlying mechanisms are unclear. Defective placentation and apoptosis of invasive cytotrophoblasts cause inadequate remodeling of spiral arteries, placental ischemia, and reduced uterine perfusion pressure (RUPP). RUPP causes imbalance between the anti-angiogenic factors soluble fms-like tyrosine kinase-1 and soluble endoglin and the pro-angiogenic vascular endothelial growth factor and placental growth factor, and stimulates the release of proinflammatory cytokines, hypoxia-inducible factor, reactive oxygen species, and angiotensin AT receptor agonistic autoantibodies. Read More

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http://doi.wiley.com/10.1111/micc.12508
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October 2018
10 Reads

Sphingosine-1-phosphate protects against brain microvascular endothelial junctional protein disorganization and barrier dysfunction caused by alcohol.

Microcirculation 2019 Jan 17;26(1):e12506. Epub 2018 Oct 17.

Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.

Objective: S1P has known endothelial barrier-protective properties, but whether this extends to the BBB is unclear. We hypothesized that alcohol-induced disruption of brain microvascular endothelial barrier function and junctional protein organization can be ameliorated by S1P treatment.

Methods: Cultured primary HBMEC monolayers were used to characterize endothelial-specific mechanisms of BBB regulation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335152PMC
January 2019

Microvascular circulatory dysregulation driven in part by cystathionine gamma-lyase: A new paradigm for cardiovascular compromise in the preterm newborn.

Microcirculation 2019 Feb 30;26(2):e12507. Epub 2018 Oct 30.

Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.

Objective: H S may explain the dysregulation of microvascular tone associated with poor outcome following preterm birth. In adult vasculature, H S is predominantly produced by CSE. We hypothesized that vascular CSE activity contributes to microvascular tone regulation during circulatory transition. Read More

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http://dx.doi.org/10.1111/micc.12507DOI Listing
February 2019
5 Reads

Relationship between the endothelial glycocalyx and the extent of coronary atherosclerosis.

Microcirculation 2018 11 8;25(8):e12504. Epub 2018 Oct 8.

Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Objective: To investigate the correlation between the EG and the severity of coronary atherosclerosis.

Methods: A total of193 subjects were divided into two groups. A SDF video microscope with a glycocalyx thickness measurement system was used to visualize the sublingual microcirculation. Read More

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http://dx.doi.org/10.1111/micc.12504DOI Listing
November 2018
4 Reads

A new complimentary web-based tool for manual analysis of microcirculation videos: Validation of the Capillary Mapper against the current gold standard AVA 3.2.

Microcirculation 2018 11 8;25(8):e12505. Epub 2018 Oct 8.

Department of Anesthesiology, Intensive Care and Pain Therapy, University of Muenster Medical Centre, Muenster, Germany.

Objective: The aim of the current study was to compare a newly developed web-based freely accessible software program for manual analysis of the microcirculation, the Capillary Mapper (CM), with AVA 3.2 software (AVA; MicroVision Medical B.V. Read More

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http://doi.wiley.com/10.1111/micc.12505
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November 2018
20 Reads

The protective effect of betulinic acid on microvascular responsivity and protein expression in alzheimer disease induced by cerebral micro-injection of beta-amyloid and streptozotocin.

Microcirculation 2018 11 8;25(8):e12503. Epub 2018 Oct 8.

Department of Physiology, Faculty of Medicine, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective: Alzheimer's disease (AD) is mainly caused by accumulation of β-amyloid (Aβ) in vessels or parenchyma of the brain. Accordingly, natural compounds such as betulinic acid (BA) might improve the AD signs by increase in blood flow and through reduction in amyloid plaques.

Methods: Intra-hippocampal injection of BA (0. Read More

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November 2018
3 Reads

Induction of microvascular network growth in the mouse mesentery.

Microcirculation 2018 11 10;25(8):e12502. Epub 2018 Oct 10.

Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana.

Objective: Motivated by observations of mesenteries harvested from mice treated with tamoxifen dissolved in oil for inducible gene mutation studies, the objective of this study was to demonstrate that microvascular growth can be induced in the avascular mouse mesentery tissue.

Methods: C57BL/6 mice were administered an IP injection for five consecutive days of: saline, sunflower oil, tamoxifen dissolved in sunflower oil, corn oil, or peanut oil.

Results: Twenty-one days post-injection, zero tissues from saline group contained branching microvascular networks. Read More

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http://doi.wiley.com/10.1111/micc.12502
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November 2018
9 Reads

Modified redox signaling in vasculature after chronic infusion of the insulin receptor antagonist, S961.

Microcirculation 2019 Feb 10;26(2):e12501. Epub 2018 Oct 10.

Cardiovascular and Thoracic Health, Kolling Institute of Medical Research, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

Background: Type 2 diabetes and associated vascular complications cause substantial morbidity and mortality. It is important to investigate mechanisms and test therapies in relevant physiological models, yet few animal models adequately recapitulate all aspects of the human condition.

Objective: We sought to determine the potential of using an insulin receptor antagonist, S961, in mice for investigating vascular pathophysiology. Read More

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http://dx.doi.org/10.1111/micc.12501DOI Listing
February 2019
1 Read

Variation of endothelium-related hemostatic factors during sepsis.

Microcirculation 2018 11 10;25(8):e12500. Epub 2018 Oct 10.

Intensive Care Unit, 1st Department of Respiratory Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Objective: The thrombomodulin/protein C and VWF/ADAMTS-13 pathways are disturbed in sepsis and have been implicated in the coagulation disorders that characterize the septic syndrome. We aimed to assess the variation of these endothelial parameters during sepsis and their putative association with outcome, in critically ill, septic patients.

Methods: We monitored 34 septic patients, 23 of whom improved (group A) while 11 deteriorated (group B). Read More

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http://dx.doi.org/10.1111/micc.12500DOI Listing
November 2018
9 Reads

LncRNA-FENDRR mediates VEGFA to promote the apoptosis of brain microvascular endothelial cells via regulating miR-126 in mice with hypertensive intracerebral hemorrhage.

Microcirculation 2018 11 10;25(8):e12499. Epub 2018 Oct 10.

Department of Neurosurgery, The Fourth Affiliated Hospital of Baotou Medical College, Baotou Eighth Hospital, Baotou, China.

Background: LncRNA-FENDRR is a kind of endothelial genes critical for vascular development. Moreover, miR-126 and vascular endothelial growth factor A (VEGFA) are also involved in the physiological process of vascular endothelial cells. This study aimed to the underlying mechanism of FENDRR involving miR-126 and VEGFA in hypertensive intracerebral hemorrhage (HICH). Read More

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http://doi.wiley.com/10.1111/micc.12499
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November 2018
19 Reads

Mast cells and primary systemic vasculitides.

Microcirculation 2018 11 12;25(8):e12498. Epub 2018 Sep 12.

Department of Medicine, Human Anatomy Section, University of Udine Medical School, Udine, Italy.

Vasculitides are characterized by inflammation and necrosis of blood vessels leading to vessel occlusion and ischemic damages of tissues. Among the inflammatory cells involved in vasculitides, neutrophils, T cells, and macrophages have been identified as the predominant cell type. This review article is focused on the role of mast cells in these chronic inflammatory processes. Read More

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November 2018
1 Read

Skeletal muscle interstitial O pressures: bridging the gap between the capillary and myocyte.

Microcirculation 2018 Aug 18:e12497. Epub 2018 Aug 18.

Departments of Anatomy & Physiology, Kinesiology, Kansas State University, Manhattan, Kansas.

The oxygen transport pathway from air to mitochondria involves a series of transfer steps within closely integrated systems (pulmonary, cardiovascular, and tissue metabolic). Small and finite O stores in most mammalian species require exquisitely controlled changes in O flux rates to support elevated ATP turnover. This is especially true for the contracting skeletal muscle where O requirements may increase two orders of magnitude above rest. Read More

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http://doi.wiley.com/10.1111/micc.12497
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http://dx.doi.org/10.1111/micc.12497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379155PMC
August 2018
9 Reads

The contribution of carbon monoxide to vascular tonus.

Microcirculation 2018 10 27;25(7):e12495. Epub 2018 Aug 27.

Department of Physiology, Medical Faculty, Akdeniz University, Antalya, Turkey.

Objective: The aim of this descriptive study was to examine the contribution of CO in the maintenance of vascular tonus in different organs and different vessel segments; the underlying mechanism of CO-induced vasodilation was investigated.

Methods: Sixty Wistar albino rats, aged 6-8 months, were used in this study. Response to CO by isolated arteries from the thoracic and abdominal aorta and mesenteric, renal, gastrocnemius, and gracilis muscles as well as heart, lung, and brain vascular beds was endogenously and exogenously studied using organ baths or myograph. Read More

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October 2018
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Arteriolar and capillary responses to CO and H in hamster skeletal muscle microvasculature: Implications for active hyperemia.

Microcirculation 2018 10 27;25(7):e12494. Epub 2018 Aug 27.

Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.

Objective: We hypothesized that CO and H stimulate capillaries and arterioles to produce local and conducted vasodilations required to coordinate the distribution of blood flow to contracting skeletal muscle fibers.

Methods: CO and H independently and in combination were applied to 2A arterioles (first branch order from the 1A feed arteriole) and capillaries of the in situ, blood-perfused hamster cremaster muscle. The resulting local and conducted vasodilations were measured. Read More

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October 2018

The pulmonary microvasculature entraps induced vascular progenitor cells (iVPCs) systemically delivered after cardiac ischemia-reperfusion injury: Indication for preservation of heart function via paracrine effects beyond engraftment.

Microcirculation 2019 Feb 27;26(2):e12493. Epub 2018 Aug 27.

Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne, Vic., Australia.

Objective: Stem cell-based regenerative therapies have been intensively studied with the aim to define an ideal cell type for the treatment of myocardial infarction. We tested systemically delivered, platelet-targeted induced vascular progenitor cells (iVPCs) to study their potential to salvage damaged myocardium after ischemia-reperfusion injury.

Methods: Using a mouse model of ischemia-reperfusion injury, we tested the potential of platelet-targeted iVPCs (1 × 10 targ-iVPCs) compared to non-targ-iVPCs and a saline control. Read More

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February 2019
2.565 Impact Factor

Reversible impairment of coronary flow reserve in acute myocarditis.

Microcirculation 2018 10 5;25(7):e12491. Epub 2018 Aug 5.

Institute of Cardiovascular-metabolic Research (ICMR), Medical Faculty of the Johannes Kepler University, Linz, Austria, Europe.

Objective: Acute myocarditis is accompanied by an impaired coronary microcirculation. These microcirculatory disturbances are not well defined, and data are derived from complex invasive measurements. Therefore, this study aimed to evaluate the inflammation-induced microcirculatory dysfunction including its reversibility and association with markers of inflammation severity (extent of LGE on CMR imaging and laboratory markers of myocardial necrosis) using the noninvasive technique of echocardiographic CFR measurement. Read More

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October 2018
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Insulin resistance disrupts cell integrity, mitochondrial function, and inflammatory signaling in lymphatic endothelium.

Microcirculation 2018 10 27;25(7):e12492. Epub 2018 Aug 27.

Department of Medical Physiology, College of Medicine, Texas A&M University, College Station, Texas.

Objective: Lymphatic vessel dysfunction and increased lymph leakage have been directly associated with several metabolic diseases. However, the underlying cellular mechanisms causing lymphatic dysfunction have not been determined. Aberrant insulin signaling affects the metabolic function of cells and consequently impairs tissue function. Read More

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http://dx.doi.org/10.1111/micc.12492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170722PMC
October 2018

Ovarian hormones modulate endothelin-1 receptor responses in young women.

Microcirculation 2018 10 25;25(7):e12490. Epub 2018 Jul 25.

Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware.

Objective: We recently demonstrated ETB mediate vasodilation in young but not postmenopausal women; it is unclear if this is related to age or a decline in ovarian hormones. The purpose of this study was to test the hypothesis that ETB responses are modulated by ovarian hormones.

Methods: We measured cutaneous vasodilatory responses in 12 young women (22 ± 1 years, 23 ± 1 kg/m ) during the ML (days 20-25) and EF (days 2-5) phases of the menstrual cycle. Read More

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October 2018
11 Reads

Abstracts of the 68 annual meeting in University of Nottingham.

Authors:
Melissa Gammons

Microcirculation 2018 Jul 2:e12489. Epub 2018 Jul 2.

MRC Laboratory for Molecular Biology.

Placental hypervascularization observed in gestational diabetes mellitus (GDM) may be related to functional availability of vascular endothelial growth factor (VEGF) and its receptors. We aimed to test whether changes in phosphorylation of tyrosine 951 or tyrosine 1175 (pY951 or pY1175) of the vascular endothelial growth factor receptor 2 (VEGFR2) are associated with the proangiogenic state observed in placentas from GDM This article is protected by copyright. All rights reserved. Read More

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July 2018
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Utilizing state-of-the-art "omics" technology and bioinformatics to identify new biological mechanisms and biomarkers for coronary artery disease.

Microcirculation 2019 Feb 23;26(2):e12488. Epub 2018 Jul 23.

Cardiothoracic and Vascular Health, Kolling Institute and Department of Cardiology, Royal North Shore Hospital, Northern Sydney Local Health District, Sydney, NSW, Australia.

Identification of the four standard modifiable cardiovascular risk factors (SMuRFs)-diabetes mellitus, hyperlipidaemia, hypertension, and cigarette smoking-has allowed the development of risk scores. These have been used in conjunction with primary and secondary prevention strategies targeting SMuRFs to reduce the burden of CAD. Recent studies show that up to 25% of ACS patients do not have any SMuRFs. Read More

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February 2019
6 Reads

The role of senescence, telomere dysfunction and shelterin in vascular aging.

Microcirculation 2019 Feb 12;26(2):e12487. Epub 2018 Sep 12.

Department of Internal Medicine, University of Utah, Salt Lake City, Utah.

In the United States and other westernized nations, CVDs are the leading cause of death in adults over 65 years of age. Large artery stiffness and endothelial dysfunction are increased with age and age-associated arterial dysfunction is an important antecedent of CVDs. One age-associated change that may contribute to vascular dysfunction and CVD risk is an increase in the number of resident senescent cells in the vasculature. Read More

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February 2019
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Differential arterial and venous endothelial redox responses to oxidative stress.

Microcirculation 2018 10 23;25(7):e12486. Epub 2018 Jul 23.

Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.

Objective: Oxidative stress is a central event linked with endothelial dysfunction and inflammation in several vascular pathologies, marked by over-production of ROS and concomitant decreases in antioxidants, for example GSH. Here, we distinguish endothelial oxidative stress regulation and associated functional disparities in the two main vascular conduits, (arteries and veins) following decreases in GSH.

Methods: MAECs and VCECs were used as models of arterial and venular endothelium, respectively, and BSO (0-100 μmol/L) was used to indirectly increase cellular oxidative stress. Read More

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http://dx.doi.org/10.1111/micc.12486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226026PMC
October 2018
1 Read

Extracellular vesicles and microvascular pathology: Decoding the active dialogue.

Microcirculation 2019 Feb 23;26(2):e12485. Epub 2018 Jul 23.

Vascular Immunology Unit, Department of Pathology, School of Medical Sciences, Marie Bashir Institute and The University of Sydney Nano Institute (Sydney Nano), The University of Sydney, Camperdown, NSW, Australia.

Extracellular vesicles (EV) are a heterogeneous collection of membrane-surrounded structures released from all studied cells, under both physiological and pathological conditions. These nano-size vesicles carry complex cargoes including different classes of proteins, lipids and nucleic acids and are known to act as a communication and signalling vesicles in various cellular process. In addition to their role in development and progression of pathological disorders which make them potentially great biomarkers, EV have beneficial effects, as they take part in homeostasis. Read More

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February 2019