4,359 results match your criteria Microbial Pathogenesis [Journal]


Genotyping of long term persistent Staphylococcus aureus in bovine subclinical mastitis.

Microb Pathog 2019 Apr 20. Epub 2019 Apr 20.

Department of Microbiology and Immunology, Institute of Biosciences, Sao Paulo State University, Botucatu, SP, Brazil. Electronic address:

Bovine mastitis affects dairy cattle worldwide and Staphylococcus aureus is one of the most common microorganisms involved in subclinical and chronic disease. Superantigens, such as enterotoxins contribute to S. aureus persistence and pathogenicity in this disease. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.031DOI Listing

Probiotic potential of Weissella strains isolated from horse feces, a probable equine probiotic.

Microb Pathog 2019 Apr 19. Epub 2019 Apr 19.

College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, People's Republic of China. Electronic address:

In this study, we isolated four Weissella confusa strains from the healthy horse feces to test their potential as equine probiotics. The identification and characteristics of these isolates were determined as per standard methods. Resistance and susceptibility of the isolated strains were tested to low pHs, different heat treatments, commonly used antibiotics and against the pathogenic strains of Salmonella, Pasteurella, Staphylococcus aureus, and Escherichia coli. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.032DOI Listing
April 2019
1 Read

Immunogenic evaluation of FMD virus immuno-dominant epitopes coupled with IL-2/FcIgG in BALB/c mice.

Microb Pathog 2019 Apr 17. Epub 2019 Apr 17.

Razi Vaccine and Serum Research Institute, Mashhad, Iran.

Previous studies on vaccine development against foot-and-mouth disease (FMD) virus reported that application of the inactivated vaccines for FMD virus is not completely effective. Novel vaccinations based on immune-dominant epitopes showed they induced immune responses. In addition, for better and safer immunization, access to of efficient adjuvants against FMD virus seems to be critical. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010183075
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http://dx.doi.org/10.1016/j.micpath.2019.04.019DOI Listing
April 2019
1 Read

Immunization of mice by the co-administration of codon-optimized HPV16 E7 and lL12 genes against HPV16-associated cervical cancer.

Microb Pathog 2019 Apr 17;132:20-25. Epub 2019 Apr 17.

Infectious Disease Research Center, Golestan University of Medical Sciences, Gorgan, Iran; Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. Electronic address:

Background: Various promising procedures have been used to improve the potency of DNA vaccines for the treatment of human papillomavirus type 16 (HPV16) infections. Interleukin-12 (IL12) is a powerful adjuvant that can contribute to T cell-mediated protection against many pathogens, specifically viruses. Considering the important role of T cell-mediated immunity in tumor clearance, the induction of these responses can help control the progression of tumors in animal models. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.028DOI Listing
April 2019
1 Read

Staphylococcus aureus versus neutrophil: Scrutiny of ancient combat.

Microb Pathog 2019 Apr 16. Epub 2019 Apr 16.

Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Staphylococcus aureus (S.aureus) is a Gram-positive bacterium that causes many infections and diseases. This pathogen can cause many types of infections such as impetigo, toxic shock syndrome toxin (TSST1), pneumonia, endocarditis, and autoimmune diseases like lupus erythematosus and can infect other healthy individuals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010193037
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http://dx.doi.org/10.1016/j.micpath.2019.04.026DOI Listing
April 2019
3 Reads

Characterization, high production and antimicrobial activity of exopolysaccharides from Lactococcus lactis F-mou.

Microb Pathog 2019 Apr 17;132:10-19. Epub 2019 Apr 17.

Laboratory of Molecular Biology, Genomics and Bioinformatics, Faculty of Nature and Life Science, Hassiba Benbouali University, Chlef, Hay Essalam, 02000, Algeria.

A new exopolysaccharide (EPS) was produced by the Lactococcus lactis F-mou strain (LT898177.1) isolated from the Sahrawi camel milk in the Bir-Naam region, Algeria. The most influential production parameters were screened by the Plackett-Burman design for enhancing EPS yield utilizing the Mech-Degla juice as a low-cost raw material. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010183207
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http://dx.doi.org/10.1016/j.micpath.2019.04.018DOI Listing
April 2019
2 Reads

Baicalin tetrazole acts as anti-pneumocystis carinii pneumonia candidate in immunosuppressed rat model.

Microb Pathog 2019 Apr 16. Epub 2019 Apr 16.

Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. Electronic address:

The present study was aimed to synthesize and evaluate tetrazoles of baicalin against Pneumocystis carinii pneumonia in the rat model. Among the seven synthesized baicalin tetrazoles, one with trifloromethyl group in the aromatic ring was found to be most potent during the initial study. The mechanism of preventive effect of most potent compound 4c against Pneumocystis carinii pneumonia was investigated in detail. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.027DOI Listing

Biosynthesis, characterization and antimicrobial activities of zinc oxide nanoparticles from leaf extract of Mentha pulegium (L.).

Microb Pathog 2019 Apr 17;131:239-245. Epub 2019 Apr 17.

Department of Chemistry, Quchan Branch, Islamic Azad University, Quchan, Iran.

The synthesis of metal and semiconductor nanoparticles is an expanding research area due to the potential applications in the development of novel technologies. In the present study, a simple and eco-friendly synthesis of zinc oxide nanoparticles (ZnO NPs) using leaf extract of Mentha pulegium L. has been used. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.022DOI Listing

Conjugal transfer of PMQR from uropathogenic E.coli under high ciprofloxacin selection pressure generates gyrA mutation.

Microb Pathog 2019 Apr 15. Epub 2019 Apr 15.

Department of Biochemistry and Medical Biotechnology, Calcutta School of Tropical Medicine, Kolkata, India. Electronic address:

Incidence of high fluoroquinolone resistance has been rising rapidly worldwide. Resistance against fluoroquinolones can be either chromosomal or plasmid mediated. Plasmid mediated quinolone resistant(PMQR) genes impart low level of resistance against fluoroquinolones but provides favorable background for selection of additional chromosomally encoded resistance mechanisms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010193019
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http://dx.doi.org/10.1016/j.micpath.2019.04.021DOI Listing
April 2019
1 Read

L. pseudomesenteroides and L. johnsonii isolated from yaks in Tibet modulate gut microbiota in mice to ameliorate enteroinvasive Escherichia coli-induced diarrhea.

Microb Pathog 2019 Apr 15;132:1-9. Epub 2019 Apr 15.

College of Animals Husbandry and Veterinary Medicine, Tibet Agriculture and Animal Husbandry University, Linzhi, Tibet, 860000, PR China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, PR China. Electronic address:

Enteroinvasive Escherichia coli (EIEC) are well-known food-borne pathogens that cause animal intestinal diseases. Lactobacillus is believed to inhibit intestinal pathogens and maintain a healthy gut microbiota. This study aimed to investigate the effects of pre-supplementation of Lactobacillus from yaks (4500m) to prevent the clinical symptoms and the improvement of the disordered flora caused by E. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010193014
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http://dx.doi.org/10.1016/j.micpath.2019.04.020DOI Listing
April 2019
2 Reads

Canine distemper virus increased the differentiation of CD4CD8 T cells and mRNA expression of inflammatory cytokines in peripheral blood lymphocyte from canine.

Microb Pathog 2019 Apr 15;131:254-258. Epub 2019 Apr 15.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, No. 5333 Xi'an Road, Changchun, Jilin 130062, China. Electronic address:

Background: Canine distemper virus (CDV) can cause a highly contagious disease to canid. However, how CDV affects peripheral blood lymphocyte (PBL) remains unclear.

Methods: In this study, CDV infected PBL was cultured to investigate the effect of CDV on the differentiation of lymphocytes and the mRNA expression of inflammatory cytokines in PBL. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010193009
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http://dx.doi.org/10.1016/j.micpath.2019.04.025DOI Listing
April 2019
2 Reads

Comparison of MALDI-TOF MS Biotyper and 16S rDNA sequencing for identification of Pseudomonas species isolated from fish.

Microb Pathog 2019 Apr 15. Epub 2019 Apr 15.

Institute of Food and Environmental Hygiene, Faculty of Veterinary Medicine, Latvia University of Life Sciences and Technologies, K. Helmaņa iela 8, LV-3004, Jelgava, Latvia.

Effective and reliable methods of identification of Pseudomonas spp. are important for characterization of microorganisms. The aim of present study was to compare identification conducted with MALDI-TOF MS Biotyper and 16S rDNA sequencing of Pseudomonas species isolated from fish. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010193042
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http://dx.doi.org/10.1016/j.micpath.2019.04.024DOI Listing
April 2019
1 Read

Association between the mannose-binding lectin (MBL)-2 gene variants and serum MBL with pulmonary tuberculosis: An update meta-analysis and systematic review.

Microb Pathog 2019 Apr 15. Epub 2019 Apr 15.

Department of Respiratory Medicine and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, China. Electronic address:

In recent years, many studies have demonstrated that the MBL-2 gene polymorphisms may be associated with pulmonary tuberculosis (PTB) susceptibility. Moreover, some studies have shown that serum MBL levels were influenced by the MBL-2 gene polymorphisms and that it plays an important role in tuberculosis infection. However, the results of these studies were inconsistent and underpowered. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010193039
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http://dx.doi.org/10.1016/j.micpath.2019.04.023DOI Listing
April 2019
1 Read

Attenuated Listeria monocytogenes protecting zebrafish (Danio rerio) against Vibrio species challenge.

Microb Pathog 2019 Apr 12. Epub 2019 Apr 12.

School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, PR China. Electronic address:

Live attenuated bacteria is a promising candidate vector for the delivery of vaccines in clinic trials. In the field of aquaculture industry, live vector vaccine also could provide long-term and effective protection against fish bacterial diseases. In our previous work, we demonstrated attenuated Listeria monocytogenes (Lm) had the potential to be an aquaculture vaccine vector in cellular level and zebrafish model. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010193011
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http://dx.doi.org/10.1016/j.micpath.2019.03.040DOI Listing
April 2019
6 Reads

The regulatory role of C1q on Helicobacter pylori-induced inflammatory cytokines secretion in THP-1 cells.

Microb Pathog 2019 Apr 12;131:234-238. Epub 2019 Apr 12.

School of Basic Medical Sciences, Binzhou Medical University, Yantai, 264003, China. Electronic address:

C1q, as a LAIR-1 ligand, maintains monocytes quiescence and possess immunosuppressive properties. To understand the roles and molecular mechanisms, C1q mediated inflammation cytokines and several pivotal proteins in THP-1 cells after H. pylori infection were detected. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.017DOI Listing
April 2019
2 Reads

Influences of stress hormones on microbial infections.

Microb Pathog 2019 Apr 11. Epub 2019 Apr 11.

Department of Pharmaceutical Microbiology, School of Life Science and Technology, China Pharmaceutical University, Jiangsu Province, Nanjing, 210009, PR China. Electronic address:

Stress hormones have been recently suggested to influence the pathogenicity of bacteria significantly. Stress has been identified as part of the factors causing an outbreak of infections in the aquaculture industry. The most studied neuroendocrine hormonal family from a microbial endocrinology perspective is the catecholamine comprising of norepinephrine, epinephrine, and dopamine. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.013DOI Listing
April 2019
2.000 Impact Factor

Generation of porcine Pasteurella multocida ghost vaccine and examination of its immunogenicity against virulent challenge in mice.

Microb Pathog 2019 Apr 10. Epub 2019 Apr 10.

College of Animal Science & Veterinary Medicine, Heilongjiang Bayi Agricultural University, No.5, XinFeng Rd., Saertu District, Daqing, Heilongjiang Province, 163319, China. Electronic address:

Pasteurella multocida (PM) causes a varity of clinical manifestation in domestic animals, even acute death. Vaccination is among effective strategy to prevent and control PM-related diseases. Bacterial ghosts (BGs) are empty bacterial envelopes, which sustain subtle antigenic comformation in bacterial outer-membrane and exhibit higher efficacy compared to inactivated vaccines. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.016DOI Listing

Transcriptional regulation of Yersinia pestis biofilm formation.

Microb Pathog 2019 Apr 10;131:212-217. Epub 2019 Apr 10.

Department of Transfusion, General Hospital of Central Theater Command, Wuhan, 430070, Hubei, China. Electronic address:

Yersinia pestis, the causative agent of plague, is transmitted primarily by infected fleas in nature. Y. pestis can produce biofilms that block flea's proventriculus and promote flea-borne transmission. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.011DOI Listing
April 2019
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Horizontal transmission of Metarhizium anisopliae between Spoladea recurvalis (Lepidoptera: Crambidae) adults and compatibility of the fungus with the attractant phenylacetaldehyde.

Microb Pathog 2019 Apr 10;131:197-204. Epub 2019 Apr 10.

International Centre of Insect Physiology and Ecology (icipe), P.O. Box 30772-00100, Nairobi, Kenya.

The compatibility of the entomopathogenic fungus Metarhizium anisopliae ICIPE 30 which was proved to be pathogenic to adult Spoladea recurvalis, and phenylacetaldehyde (PAA) floral attractant for lepidopteran moths, was investigated under laboratory and field conditions through spatial and temporal separations. Horizontal transmission of M. anisopliae ICIPE 30 between adult S. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.010DOI Listing

Antimicrobial activity of novel chalcones and modulation of virulence factors in hospital strains of Acinetobacter baumannii and Pseudomonas aeruginosa.

Microb Pathog 2019 Apr 10;131:186-196. Epub 2019 Apr 10.

Department of Microbiology and Immunology, University of Belgrade, Faculty of Pharmacy, Vojvode Stepe 450, 11221, Belgrade, Serbia. Electronic address:

Acinetobacter baumannii and Pseudomonas aeruginosa are frequent multiresistant nosocomial pathogens that cause wound and pulmonary infections in hospitalized patients. As being increasingly resistant to most clinically available antibiotics, there is a constant need for exploration of new substances that could kill them or inhibit their growth, or alternatively inhibit some of their essential virulence factors. Chalcones are chemical compounds with well-documented antimicrobial potential. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.015DOI Listing

Immunization with the ferric iron-binding periplasmic protein HitA provides protection against Pseudomonas aeruginosa in the murine infection model.

Microb Pathog 2019 Apr 9;131:181-185. Epub 2019 Apr 9.

Department of Microbiology and Immunology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

Pseudomonas aeruginosa is a notorious pathogen with increasing multi-drug resistance. This situation makes it urgent to develop a prophylactic vaccine against this pathogen. Different virulence factors play a crucial role in P. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.014DOI Listing

In-vitro phagocytosis and intracellular killing of Pasteurella multocida B:2 by phagocytic cells of buffaloes.

Microb Pathog 2019 Apr 10;131:170-174. Epub 2019 Apr 10.

Research Centre for Ruminant Diseases, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400, Serdang, Malaysia.

Pasteurella multocida B:2 is a Gram-negative organism causing haemorrhagic septicaemia (HS) in buffaloes. It causes severe pulmonary infection, leading to infiltration of numerous macrophages and neutrophils. Despite the inflammatory response, buffaloes succumb to HS. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.012DOI Listing

Oxidative stress and antioxidant responses in Nile tilapia Oreochromis niloticus experimentally infected by Providencia rettgeri.

Microb Pathog 2019 Apr 9;131:164-169. Epub 2019 Apr 9.

Department of Physiology and Pharmacology, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Electronic address:

Bacterial diseases are one of the major problems in freshwater fish culture and have been linked to significant losses and high mortality rate. In this study, Nile tilapia Oreochromis niloticus was infected by Providencia rettgeri to evaluate the oxidative stress and antioxidant responses in the fish tissues. Juvenile Nile tilapia was divided into two groups, as follow: control (uninfected) and experimentally infected with 100 μL of P. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.007DOI Listing
April 2019
1 Read

Evaluation of adherence and anti-infective properties of probiotic Lactobacillus fermentum strain 4-17 against Escherichia coli causing urinary tract infection in humans.

Microb Pathog 2019 Apr 8;131:246-253. Epub 2019 Apr 8.

Department of Food Science and Technology, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran.

Gastrointestinal (GI) infection is one of the most common types of infectious diseases. Application of probiotic strains in the control of such infections represents a promising approach. In this study, Lactobacillus fermentum strain 4-17 was isolated from kashkineh, an Iranian cereal fermented food, and identified by sequencing its 16S rRNA gene using universal primers. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.006DOI Listing
April 2019
2 Reads

Characterization of serine acetyltransferase (CysE) from methicillin-resistant Staphylococcus aureus and inhibitory effect of two natural products on CysE.

Microb Pathog 2019 Apr 9;131:218-226. Epub 2019 Apr 9.

Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, 116044, China. Electronic address:

Methicillin-resistant Staphylococcus aureus (MRSA) is a major hospital-acquired infective pathogen that has developed resistance to many antibiotics. It is imperious to develop novel anti-MRSA drugs to control the emergence of drug resistance. The biosynthesis of cysteine in bacteria is catalyzed by CysE and CysK. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.002DOI Listing

Anti-staphylococcal activity of Syagrus coronata essential oil: Biofilm eradication and in vivo action on Galleria mellonela infection model.

Microb Pathog 2019 Apr 6;131:150-157. Epub 2019 Apr 6.

Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil. Electronic address:

In this study, essential oil extracted from Syagrus coronata seeds (SCEO) was evaluated for antibacterial and antibiofilm activities against Staphylococcus aureus; in addition, Galleria mellonella model was used as an in vivo infection model. SCEO was mainly composed by fatty acids (89.79%) and sesquiterpenes (8. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.009DOI Listing
April 2019
2 Reads

Sodium butyrate ameliorates Corynebacterium pseudotuberculosis infection in RAW264.7 macrophages and C57BL/6 mice.

Microb Pathog 2019 Apr 6;131:144-149. Epub 2019 Apr 6.

College of Animal Science, Rongchang Campus of Southwest University, No. 160 Xueyuan Road, Rongchang District, Chongqing, 402460, China; Veterinary Science Engineering Research Center of Chongqing, No. 160 Xueyuan Road, Rongchang District, Chongqing, 402460, China. Electronic address:

Corynebacterium pseudotuberculosis (CP) infection in livestock has become highly difficult to control. To decrease the incidence of CP infection, the supplementation of feed with non-antibiotic antibacterial substances is a potential approach. The aim of this study was to assess the effects of sodium butyrate (NaB), a potential alternative to antibiotics, on CP infection in RAW264. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.008DOI Listing
April 2019
1 Read

Mosloflavone attenuates the quorum sensing controlled virulence phenotypes and biofilm formation in Pseudomonas aeruginosa PAO1: In vitro, in vivo and in silico approach.

Microb Pathog 2019 Apr 5;131:128-134. Epub 2019 Apr 5.

Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry, India. Electronic address:

Quorum sensing (QS) is the cell density dependent communication network which coordinates the production of pathogenic determinants in majority of pathogenic bacteria. Pseudomonas aeruginosa causes hospital-acquired infections by virtue of its well-defined QS network. As the QS regulatory network in P. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.005DOI Listing
April 2019
1 Read
2.000 Impact Factor

Musa basjoo regulates the gut microbiota in mice by rebalancing the abundance of probiotic and pathogen.

Microb Pathog 2019 Apr 3;131:205-211. Epub 2019 Apr 3.

College of Food Science & Institute of Food Biotechnology, South China Agricultural University, Guangzhou, 510640, China; Research Center for Micro-Ecological Agent Engineering and Technology of Guangdong Province, Guangzhou, 510640, China. Electronic address:

Musa basjoo is a kind of popular slimming fruit in southern China. However, even though the trophic component and physiological effect are well studied, its internal mechanism in reconstructing gut microbiota remains unclear. In this study, maturity of M. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.003DOI Listing
April 2019
3 Reads

The lung microbiome, vitamin D, and the tuberculous granuloma: A balance triangle.

Microb Pathog 2019 Apr 3;131:158-163. Epub 2019 Apr 3.

Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, USA. Electronic address:

Mycobacterium tuberculosis (Mtb) has the extraordinary ability to persist for decades within granulomas in the human host. These histopathological structures involved in both protection and pathogenesis, are subject to various influences from the host systemically and through micro-niche environments. Despite the fact that vitamin D (VD) has a key role in macrophage activation and mycobacterial clearance in the early stages of Mtb infection, the overall role of VD in granuloma maintenance or functionality has been scarcely studied. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.041DOI Listing
April 2019
2 Reads

Candida albicans cell wall mannoprotein synergizes with lipopolysaccharide to affect RAW264.7 proliferation, phagocytosis and apoptosis.

Microb Pathog 2019 Apr 3;131:98-105. Epub 2019 Apr 3.

NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology(China Medical University), The First Hospital of China Medical University, China. Electronic address:

With the widespread use of invasive surgery, immunosuppressive therapy and broad-spectrum antibiotics, there has resulted a corresponding increase in severe systemic infections as produced by Candida albicans (C.albicans), as it combines with bacterial infections. Such infections often result in high rates of mortality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010183192
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http://dx.doi.org/10.1016/j.micpath.2019.03.038DOI Listing
April 2019
5 Reads

Rhamnolipid-involved antibiotics combinations improve the eradication of Helicobacter pylori biofilm in vitro: A comparison with conventional triple therapy.

Microb Pathog 2019 Apr 2;131:112-119. Epub 2019 Apr 2.

Lab of Pharmaceutic, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, PR China. Electronic address:

Antibiotics resistance of H. pylori has been increasing constantly accompanied with decreasing clearance rate clinically, which is demonstrated to be closely related to biofilms with higher resistance than planktonic bacteria for the dense extracellular polymeric substances. Rhamnolipid (RHL) is proved to not only damage the structure of biofilm, but also potentially inhibit bacterial adhesion. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.001DOI Listing

In vitro and in silico docking studies of antibacterial compounds derived from endophytic Penicillium setosum.

Microb Pathog 2019 Apr 2;131:87-97. Epub 2019 Apr 2.

School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, 686560, India. Electronic address:

Occasionally, endophytic fungal species cognize as a hidden prospective source of plant secondary metabolites. In this study, a potent Penicillium setosum sp. nov. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.033DOI Listing
April 2019
1 Read

Isolation, characterization, and PCR-based molecular identification of a siphoviridae phage infecting Shigella dysenteriae.

Microb Pathog 2019 Apr 1;131:175-180. Epub 2019 Apr 1.

State Key Laboratory Cultivation Base of MOST, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, PR China; Jiangsu University, Zhenjiang, Jiangsu, 212013, China. Electronic address:

Background: Shigella dysenteriae is one of the members of Shigella genus which was the main responsible of different Shigellosis outbreaks worldwide. The increasing consumption of antibiotics has led to the emergence and spreading of antibiotic-resistant strains. Therefore, finding new alternatives for infection control is essential, one of which is using bacteriophages. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.037DOI Listing
April 2019
2 Reads

Baicalein triazole prevents respiratory tract infection by RSV through suppression of oxidative damage.

Microb Pathog 2019 Mar 31;131:227-233. Epub 2019 Mar 31.

Department of Critical Care Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, China; Intensive Medical, Jining Medical University, Jining, Shandong, 272029, China. Electronic address:

Baicalein, an isolate of secutellaria baicalensis is known for its anti-inflammatory activity. In the present study, 12-triazole derivatives of baicalein were synthesized and evaluated against RSV infected BEAS-2B cells in vitro and in mice model in vivo. The preventive effect of most active compound 5f against RSV infection was studied in detail. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.026DOI Listing
March 2019
3 Reads

Role of NOD1/NOD2 receptors in Fusobacterium nucleatum mediated NETosis.

Microb Pathog 2019 Mar 30;131:53-64. Epub 2019 Mar 30.

Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Polymorphonuclear neutrophils (PMNs) are indispensable in fighting infectious microbes by adopting various antimicrobial strategies including phagocytosis and neutrophil extracellular traps (NETs). Although the role and importance of PMNs in periodontal disease are well established, the specific molecular mechanisms involved in NET formation are yet to be characterized. In the present study, we sought to determine the role of periodontal pathogen on NET formation by utilizing Fusobacterium nucleatum. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.036DOI Listing
March 2019
1 Read

Study on Streptococcus agalactiae infection in Javanese medaka (Oryzias javanicus Bleeker, 1854) model.

Microb Pathog 2019 Mar 30;131:47-52. Epub 2019 Mar 30.

Department of Biology, Faculty of Science, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia.

This study determines the median lethal dose, and describes the clinico-pathological changes and disease development following Streptococcus agalactiae infection in Javanese medaka model. Javanese medakas were infected with S. agalactiae via intraperitoneal (IP) from 10 to 10 CFU/mL, and immersion (IM) route from 10 to 10 CFU/mL. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.034DOI Listing

Antimicrobial resistance and virulence genes of Streptococcus isolated from dairy cows with mastitis in China.

Microb Pathog 2019 Mar 30;131:33-39. Epub 2019 Mar 30.

Haidu College.Qingdao Agricultural University, Laiyang, 265200, PR China. Electronic address:

Streptococcus is a major mastitis-causing pathogen in dairy cows. To investigate the prevalence, antimicrobial resistance and virulence gene of Streptococcus in mastitic milk, a total of 735 mastitic raw milk samples from dairy cows in 11 provinces of China were collected and tested. Antimicrobial resistance of Streptococcus isolates was determined by disc diffusion against 8 classes 29 antimicrobial agents, and Streptococcus resistant genes and virulence genes were determined by PCR and agarose gel electrophoresis. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.035DOI Listing
March 2019
2 Reads

The protective role of autophagy in sepsis.

Microb Pathog 2019 Mar 30;131:106-111. Epub 2019 Mar 30.

Department of Intensive Care Unit, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei Province, China. Electronic address:

Sepsis is characterized by life-threatening organ dysfunction caused by a deregulated host response to infection. Autophagy is one of the innate immune defense mechanisms against microbial attack. Previous studies have demonstrated that autophagy is activated initially in sepsis, followed by a subsequent phase of impairment. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.039DOI Listing
March 2019
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Immunomodulatory molecules regulate adhesin gene expression in Staphylococcus aureus: Effect on bacterial internalization into bovine mammary epithelial cells.

Microb Pathog 2019 Mar 28;131:15-21. Epub 2019 Mar 28.

Centro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, Mexico. Electronic address:

Staphylococcus aureus is a major pathogen of subclinical bovine mastitis that usually is chronic and recurrent, which has been related to its ability to internalize into bovine mammary epithelial cells (bMECs). Previously, we reported that short and medium fatty acids and cholecalciferol reduce S. aureus internalization into pretreated-bMECs with these molecules suggesting a role as immunomodulatory agents. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.030DOI Listing
March 2019
3 Reads

Immunogenic reactivity of recombinant PKF and AbOmpA proteins as serum resistance factors against sepsis of Acinetobacter baumannii.

Microb Pathog 2019 Mar 28;131:9-14. Epub 2019 Mar 28.

Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Acinetobacter baumannii is considered as a major cause of nosocomial infection worldwide. Various vaccine formulations have been mostly studied based on secreted or surface-exposed proteins of A. baumannii in murine models. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.031DOI Listing
March 2019
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Peripheral blood and hepatic Toll-like receptor 7 expression and interferon lambda 1 levels in chronic hepatitis C: Relation to virus replication and liver injury.

Microb Pathog 2019 Mar 26;131:65-74. Epub 2019 Mar 26.

Department of Internal Medicine (Hepatobiliary Unit), Faculty of Medicine, University of Alexandria, Egypt.

Background And Aim: Toll-like receptor 7 (TLR7) can recognize single-stranded RNA viruses like hepatitis C virus (HCV) with subsequent induction of different interferon (IFN) types including IFN lambda (IFNL), which activate an immediate anti-viral response. However, the role of TLR7 in inflammation and fibrosis, characteristics of HCV-induced liver injury, is still controversial. The present work was designed to investigate the potential role of TLR7 and IFNL1 in chronic hepatitis C (CHC) in relation to viral replication and liver injury. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.032DOI Listing
March 2019
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A review of the current evidence of fruit phenolic compounds as potential antimicrobials against pathogenic bacteria.

Microb Pathog 2019 May 24;130:259-270. Epub 2019 Mar 24.

Laboratório de Microbiologia de Alimentos, Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, Brazil. Electronic address:

Fruits are among the main natural sources of phenolic compounds (PC). These compounds exert important antioxidant properties primarily associated with the presence of hydroxyl groups in their molecular structure. Additionally, the antibacterial effects of fruit phenolic-rich extracts or individual PC commonly found in fruits have been an emerging research focus in recent years. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.025DOI Listing

Genotyping and study of adherence-related genes of Streptococcus uberis isolates from bovine mastitis.

Microb Pathog 2019 May 23;130:295-301. Epub 2019 Mar 23.

Departamento Microbiología e Inmunología, Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Universidad Nacional de Río Cuarto, Ruta Nacional 36 Km 601, Río Cuarto, Córdoba, X5804ZAB, Argentina. Electronic address:

The aim of this study was to determine the presence, conservation, and distribution of 6 potential adherence genes and their relationship with diverse molecular types in 34 S. uberis isolated from bovine mastitis in Argentina. Pulsed-field gel electrophoresis (PFGE) typing with SmaI was performed. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.027DOI Listing

Immunologic balance of regulatory T cell/T helper 17 responses in gastrointestinal infectious diseases: Role of miRNAs.

Microb Pathog 2019 Mar 23;131:135-143. Epub 2019 Mar 23.

Molecular Biology Research Center, System Biology and Poisoning Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address:

Gastrointestinal Infectious diseases (GIDs) are the second cause of death worldwide. T helper17 cells (Th17) play an important role in GIDs through production of IL-17A, IL-17F, and IL-22 cytokines. Because of their increased activities in GID, Th17 and its inflammatory cytokines can inhibit the progression and eliminate the infection. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.029DOI Listing
March 2019
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Computational screening of potential drug targets for pathogens causing bacterial pneumonia.

Microb Pathog 2019 May 23;130:271-282. Epub 2019 Mar 23.

Department of Biotechnology, Thapar Institute of Engineering & Technology, Patiala, Punjab 147004, India. Electronic address:

Streptococcus pneumoniae is widely recognized as the main cause of bacterial pneumonia among all age groups. Other important gram-positive, gram-negative and atypical bacteria causing pneumonia majorly infect children and infants. Despite abundant occurrence of bacterial pneumonia, there is no specific antibiotic therapy available. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.024DOI Listing
May 2019
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2.000 Impact Factor

Coronatine elicitation alters chemical composition and biological properties of cumin seed essential oil.

Microb Pathog 2019 May 23;130:253-258. Epub 2019 Mar 23.

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmacodynamics and Toxicology School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

The present experiment evaluated how coronatine (COR) elicitation affects chemical and biological properties of cumin (Cuminum cyminum L.) seed essential oil (CSEO). Following isolation of the EO, its chemical composition was analyzed by gas chromatography-mass spectrometry; also, its bioactivities in terms of antimicrobial/antifungal, cytotoxic (measured by MTT assay) and antioxidant effects (evaluated by DPPH, β-carotene bleaching (BCB) and TBARS methods) were evaluated. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.023DOI Listing

The frequency of Merkel cell polyomavirus in whole blood from immunocompetent and immunosuppressed patients with kidney disease and healthy donors.

Microb Pathog 2019 Mar 22;131:75-80. Epub 2019 Mar 22.

Ilsong Institute of Life Science, Hallym University, Anyang, Gyeonggi-do, 14066, South Korea; Department of Microbiology, College of Medicine, Hallym University, Chuncheon, Gangwon-do, 24252, South Korea. Electronic address:

Merkel cell polyomavirus (MCPyV) is a rare, aggressive and related to human diseases in immunocompromised patients. MCPyV has been detected in skin neoplasms, various cancers, immunosuppressed patients and immunocompetent individuals. Several studies have confirmed the presence of MCPyV in patients with kidney dysfunction, such as kidney transplant (KTx) and long-term dialysis patients. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.020DOI Listing
March 2019
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Rumen-derived lipopolysaccharide induced ruminal epithelium barrier damage in goats fed a high-concentrate diet.

Microb Pathog 2019 Mar 22;131:81-86. Epub 2019 Mar 22.

Circular Agriculture Research Center, Jiangsu Academy of Agricultural Sciences, Nanjing, China; Key Laboratory of Crop and Livestock Integrated Farming, Ministry of Agriculture, Nanjing, China. Electronic address:

This study aimed to investigate the mechanism of lipopolysaccharide (LPS) released in the rumen on epithelium barrier function of goats fed a HC diet. Twelve Boer goats were randomly divided into two groups: low-concentrate(LC) diet and high-concentrate(HC) diet treatment. We found that the pH of rumen fluid in the HC group was lower than in the LC group (P < 0. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.007DOI Listing
March 2019
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Autophagy induced by enterovirus 71 regulates the production of IL-6 through the p38MAPK and ERK signaling pathways.

Microb Pathog 2019 Mar 23;131:120-127. Epub 2019 Mar 23.

Fenyang College of Shanxi Medical University, Fenyang, China; Graduate School of Shanxi Medical University, Taiyuan, China. Electronic address:

Enterovirus 71 (EV71) is the main causative agent of hand, foot, and mouth disease (HFMD), which has high morbidity and mortality. It mainly threatens children under six years of age. Because of a poor understanding of its pathogenesis, there are no effective drugs to control EV71 infection. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.028DOI Listing
March 2019
1 Read