7,308,463 results match your criteria Methods in molecular biology Clifton N.J.[Journal]

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Long-term effectiveness of cinacalcet in non-dialysis patients with chronic kidney disease and secondary hyperparathyroidism.

Kidney Res Clin Pract 2019 Apr 25;38(1). Epub 2019 Apr 25.

Pharmacy Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Background: Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease (CKD). Cinacalcet use is controversial in non-dialysis patients.

Methods: This retrospective observational study recruited patients receiving cinacalcet (off-label use) in 2010 and 2011. Read More

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http://dx.doi.org/10.23876/j.krcp.18.0088DOI Listing

Compound-specific stable carbon isotope analysis of hexabromocyclododecane diastereoisomers using gas chromatography-isotope ratio mass spectrometry.

Rapid Commun Mass Spectrom 2019 Apr 25. Epub 2019 Apr 25.

State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environment Protection and Resource Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China.

Rationale: Compound-specific stable isotope analysis (CSIA) is a powerful tool for the source apportionment and characterization of environmental transformation processes, especially for new emerging contaminants. In this study, we have developed an effective method for determination of the stable carbon isotope ratios of hexabromocyclododecane diastereoisomers.

Methods: Three diastereoisomers of hexabromocyclododecane (HBCD), α-, β-, and γ-HBCD, were separated on a preparative high-performance liquid chromatography (HPLC) system. Read More

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http://dx.doi.org/10.1002/rcm.8472DOI Listing

Depression and Inflammation among Epidermal Growth Factor Receptor (EGFR) Mutant Non-Small Cell Lung Cancer Patients.

Psychooncology 2019 Apr 25. Epub 2019 Apr 25.

Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY.

Objectives: Depression is highly prevalent in Non-Small Cell Lung cancer (NSCLC) and is associated with elevated inflammation. However, certain subtypes of driver mutation associated NSCLC such as Epidermal Growth Factor Receptor (EGFR) mutated NSCLC may be associated with less depression given the differences in their underlying biology and disease trajectories. Biological variables such as inflammation, measured by C-reactive protein (CRP), may provide insight into depression variability in EGFR mutant NSCLC. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pon.5097
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http://dx.doi.org/10.1002/pon.5097DOI Listing
April 2019
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Surgical and oncological outcomes after ultrasound-guided robotic liver resections for malignant tumor. Analysis of a prospective database.

Int J Med Robot 2019 Apr 25:e2002. Epub 2019 Apr 25.

Division of Oncological and Robotic General Surgery, Careggi University Hospital, Florence, Italy.

Aim: Robotic surgery is thought to have a role in widening the application of minimally invasive liver surgery. Nonetheless, data concerning surgical results for liver malignancies are presently still lacking. We aimed to evaluate the surgical and oncological outcomes of ultrasound guided robotic liver resections for hepatic malignancies. Read More

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http://dx.doi.org/10.1002/rcs.2002DOI Listing

The double burden of food insecurity and obesity among Latino youth: Understanding the role of generational status.

Pediatr Obes 2019 Apr 25:e12525. Epub 2019 Apr 25.

Department of Public Health Education, University of North Carolina, Greenboro, NC, USA.

Background: Obesity is linked to food insecurity and generational status; however, little is known about how both impact obesity risk among Latino youth.

Objective: To investigate the joint effect of generational status and food insecurity on obesity prevalence among Latino youth.

Methods: We pooled data from the 2011 to 2017 waves of the National Health Interview Survey to derive a sample Latino youth aged 12 to 17 (N = 7532). Read More

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http://dx.doi.org/10.1111/ijpo.12525DOI Listing

Quantitative analysis of the yeast pheromone pathway.

Yeast 2019 Apr 25. Epub 2019 Apr 25.

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

The pheromone response pathway of the yeast S. cerevisiae is a well-established model for the study of G proteins and mitogen-activated protein kinase (MAPK) cascades. Our longstanding ability to combine sophisticated genetic approaches with established functional assays has provided a thorough understanding of signaling mechanisms and regulation. Read More

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http://dx.doi.org/10.1002/yea.3395DOI Listing
April 2019
1 Read
1.634 Impact Factor

Outcomes after Split Abdominal Wall Muscle Flap Repair for Large Congenital Diaphragmatic Hernias.

Eur J Pediatr Surg 2019 Apr 25. Epub 2019 Apr 25.

Department of Pediatric Surgery, Hospital Universitario Vall d'Hebron, Barcelona, Spain.

Background:  Repair of large congenital diaphragmatic hernias (CDHs) is challenging. As primary repair is not always feasible, patches are commonly used. An alternative treatment is split abdominal wall muscle flap repair, which uses vascularized autologous tissue. Read More

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http://dx.doi.org/10.1055/s-0039-1687867DOI Listing

Low Plasma Sodium Concentration Predicts Perforated Acute Appendicitis in Children: A Prospective Diagnostic Accuracy Study.

Eur J Pediatr Surg 2019 Apr 25. Epub 2019 Apr 25.

Department of Pediatric Perioperative Medicine and Intensive Care, Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, Stockholm, Sweden.

Background:  Early differentiation between perforated and nonperforated acute appendicitis (AA) in children is of major benefit for the selection of proper treatment. Based on pilot study data, we hypothesized that plasma sodium concentration at hospital admission is a diagnostic marker for perforation in children with AA.

Materials And Methods:  This was a prospective diagnostic accuracy study, including previously healthy children, 1 to 14 years of age, with AA. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1687870
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http://dx.doi.org/10.1055/s-0039-1687870DOI Listing
April 2019
1 Read

Role of Artificial Intelligence within the Telehealth Domain.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

IBM Research, Brazil.

Objectives: This paper provides a discussion about the potential scope of applicability of Artificial Intelligence methods within the telehealth domain. These methods are focussed on clinical needs and provide some insight to current directions, based on reports of recent advances.

Methods: Examples of telehealth innovations involving Artificial Intelligence to support or supplement remote health care delivery were identified from recent literature by the authors, on the basis of expert knowledge. Read More

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http://dx.doi.org/10.1055/s-0039-1677897DOI Listing

Artificial Intelligence for Participatory Health: Applications, Impact, and Future Implications.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Swinburne University of Technology, and University of Melbourne, Australia.

Objective: Artificial intelligence (AI) provides people and professionals working in the field of participatory health informatics an opportunity to derive robust insights from a variety of online sources. The objective of this paper is to identify current state of the art and application areas of AI in the context of participatory health.

Methods: A search was conducted across seven databases (PubMed, Embase, CINAHL, PsychInfo, ACM Digital Library, IEEExplore, and SCOPUS), covering articles published since 2013. Read More

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http://dx.doi.org/10.1055/s-0039-1677902DOI Listing

The Interplay of Knowledge Representation with Various Fields of Artificial Intelligence in Medicine.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Associate Professor, Department of Medical Informatics, Academic Medical Center - University of Amsterdam, Amsterdam Public Health research institute, Amsterdam, The Netherlands.

Introduction: Artificial intelligence (AI) is widespread in many areas, including medicine. However, it is unclear what exactly AI encompasses. This paper aims to provide an improved understanding of medical AI and its constituent fields, and their interplay with knowledge representation (KR). Read More

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http://dx.doi.org/10.1055/s-0039-1677899DOI Listing

Serious Games in Health Professions Education: Review of Trends and Learning Efficacy.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Games for Health Innovations Centre, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

Objectives: To provide an overview of research trends and a review regarding the learning efficacy of serious games for health professions education taking into account short-term learning outcomes.

Methods: For the review of research trends, we performed the search on Web of Science from 1996 until the present. For the scoping review on learning efficacy, ERIC, Education Source, PsychINFO, Global Health, CINAHL, Web Of Science, and Medline were searched. Read More

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http://dx.doi.org/10.1055/s-0039-1677904DOI Listing

Artificial Intelligence in Medicine: Weighing the Accomplishments, Hype, and Promise.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Department of Biomedical Informatics, Columbia University.

Introduction: Artificial Intelligence in Medicine (AIM) research is now 50 years old, having made great progress that has tracked the corresponding evolution of computer science, hardware technology, communications, and biomedicine. Characterized as being in its "adolescence" at an international meeting in 1991, and as "coming of age" at another meeting in 2007, the AIM field is now more visible and influential than ever before, paralleling the enthusiasm and accomplishments of artificial intelligence (AI) more generally.

Objectives: This article summarizes some of that AIM history, providing an update on the status of the field as it enters its second half-century. Read More

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http://dx.doi.org/10.1055/s-0039-1677891DOI Listing

Beginnings of Artificial Intelligence in Medicine (AIM): Computational Artifice Assisting Scientific Inquiry and Clinical Art - with Reflections on Present AIM Challenges.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Department of Computer Science, Rutgers University, USA.

Background: The rise of biomedical expert heuristic knowledge-based approaches for computational modeling and problem solving, for scientific inquiry and medical decision-making, and for consultation in the 1970's led to a major change in the paradigm that affected all of artificial intelligence (AI) research. Since then, AI has evolved, surviving several "winters", as it has oscillated between relying on expensive and hard-to-validate knowledge-based approaches, and the alternative of using machine learning methods for inferring classification rules from labelled datasets. In the past couple of decades, we are seeing a gradual but progressive intertwining of the two. Read More

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http://dx.doi.org/10.1055/s-0039-1677895DOI Listing

Effectiveness of Compressive External Bracing in Patients with Flexible Pectus Carinatum Deformity: A Review.

Thorac Cardiovasc Surg 2019 Apr 25. Epub 2019 Apr 25.

Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom.

There has been a growing interest in the nonoperative treatment of chest wall deformities over the last few decades; with the advent of external compressive orthotics, similar outcomes have been reported compared with surgical intervention. There have been fewer major complications reported with dynamic compression bracing on the chest wall; however, the Achilles heel of this approach still lies with treatment tolerability and compliance. A Medline literature search was undertaken to evaluate the evidence concerning the techniques, modifications, and outcomes associated with external compressive bracing in the setting of pectus carinatum. Read More

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http://dx.doi.org/10.1055/s-0039-1687824DOI Listing

Microplegia versus Cardioplexol® in Coronary Artery Bypass Surgery with Minimal Extracorporeal Circulation: Comparison of Two Cardioplegia Concepts.

Thorac Cardiovasc Surg 2019 Apr 25. Epub 2019 Apr 25.

Department of Cardiac Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland.

Background:  The aim of this study is to compare the combined use of the Myocardial Protection System and our microplegia (Basel Microplegia Protocol) with Cardioplexol in coronary artery bypass grafting using the minimal extracorporeal circulation.

Methods:  The analysis focused on propensity score matched pairs of patients in whom microplegia or Cardioplexol was used. Primary efficacy endpoints were highsensitivity cardiac troponin-T on postoperative day 1 and peak values during hospitalization. Read More

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http://dx.doi.org/10.1055/s-0039-1687843DOI Listing

Optic Nerve Lipidomics Reveal Impaired Glucosylsphingosine Lipids Pathway in Glaucoma.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1789-1798

Department of Ophthalmology & Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States.

Purpose: To determine major differences in lipid profile between human control and glaucomatous optic nerve. To assess major enzymes in lipid pathway if aberration is revealed for a lipid class by profiling.

Methods: Optic nerve (ON) samples were obtained from human cadaveric donors [control (n = 11) and primary open-angle glaucoma (POAG; n = 12)]; the lipids were extracted using Bligh and Dyer methods. Read More

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http://dx.doi.org/10.1167/iovs.18-25802DOI Listing

Effect of αvβ3 Integrin Expression and Activity on Intraocular Pressure.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1776-1788

Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, United States.

Purpose: To determine the effects of αvβ3 integrin expression and activation on intraocular pressure (IOP).

Methods: Cre+/-β3flox/flox mice were treated with topical tamoxifen eye drops for 5 days to activate Cre and excise the β3 integrin gene from the anterior segment. IOP was measured weekly for 11 weeks using rebound tonometry. Read More

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http://dx.doi.org/10.1167/iovs.18-26038DOI Listing

Overexpression of MMPs in Corneas Requiring Penetrating and Deep Anterior Lamellar Keratoplasty.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1734-1747

Department of Ophthalmology, University of California, San Francisco, California, United States.

Purpose: Matrix metalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases involved in wound healing processes, including neovascularization and fibrosis. We assessed MMP protein expression levels in diseased corneas of patients requiring penetrating and deep anterior lamellar keratoplasty. The purpose of this study was to test the hypothesis that upregulation of MMPs in diseased corneas is positively associated with clinical levels of corneal neovascularization and fibrosis. Read More

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http://dx.doi.org/10.1167/iovs.18-25961DOI Listing

Preoperative Serum Leptin Level is Associated with Preoperative Pain Threshold and Postoperative Analgesic Consumption in Patients Undergoing Cesarean Section.

Med Princ Pract 2019 Apr 26. Epub 2019 Apr 26.

Objective: This study aimed to investigate the preoperative level of serum leptin in cesarean section (C-section) patients with and without acute labor pain and its association with postoperative analgesic consumption and preoperative pain threshold.

Materials And Methods: Preoperative leptin levels, preoperative pain threshold, postoperative analgesic consumption in the following 24 hours, and postoperative pain severity (visual analog scale-VAS scores at postoperative 1st, 2nd, 4th, 6th, 12th, and 24th hours) in C-section patients with labor pain (emergency C-section; n=21) and without labor pain (elective C-section; n=25) were compared.

Results: There were no significant differences between the groups regarding the demographic characteristics. Read More

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http://dx.doi.org/10.1159/000500556DOI Listing

Bio-compatible patient-specific elastic bolus for clinical implementation.

Phys Med Biol 2019 Apr 25. Epub 2019 Apr 25.

Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of).

We investigated two types of materials with very low Shore hardness, silicon rubber (Dragon Skin) and urethane liquid rubber (Clear Flex 30), for use in 3D printing patient-specific boluses. Boluses were 3D printed with these materials using two methods of casting and direct printing. These patient-specific boluses were designed for 3D-printed elaborate human phantoms and their biological, physical, and dosimetric properties were comprehensively assessed. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1c93DOI Listing

Nanofabricated tips for device-based scanning tunneling microscopy.

Nanotechnology 2019 Apr 25. Epub 2019 Apr 25.

Universiteit Leiden, Leiden, 2300 RA, NETHERLANDS.

We report on the fabrication and performance of a new kind of tip for scanning tunneling microscopy. By fully incorporating a metallic tip on a silicon chip using modern micromachining and nanofabrication techniques, we realize so-called smart tips and show the possibility of device-based STM tips. Contrary to conventional etched metal wire tips, these can be integrated into lithographically defined electrical or photonic circuits, as well as mechanical systems. Read More

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http://dx.doi.org/10.1088/1361-6528/ab1c7fDOI Listing
April 2019
1 Read

Peptide-Binding Groove Contraction Linked to the Lack of T Cell Response: Using Complex Structure and Energy To Identify Neoantigens.

Immunohorizons 2018 Aug 10;2(7):216-225. Epub 2018 Aug 10.

Department of Immunology, Mayo Clinic, Rochester, MN 55905; and.

Using personalized peptide vaccines (PPVs) to target tumor-specific nonself-antigens (neoantigens) is a promising approach to cancer treatment. However, the development of PPVs is hindered by the challenge of identifying tumor-specific neoantigens, in part because current in silico methods for identifying such neoantigens have limited effectiveness. In this article, we report the results of molecular dynamics simulations of 12 oligopeptides bound with an HLA, revealing a previously unrecognized association between the inability of an oligopeptide to elicit a T cell response and the contraction of the peptide-binding groove upon binding of the oligopeptide to the HLA. Read More

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http://dx.doi.org/10.4049/immunohorizons.1800048DOI Listing

Nasal cytology in children with primary snoring and obstructive sleep apnoea syndrome.

Int J Pediatr Otorhinolaryngol 2019 Apr 17;122:133-137. Epub 2019 Apr 17.

Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy. Electronic address:

Objective: Rhinitis is an acute or chronic inflammatory condition due to several causes (i.e. infections, allergens). Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.04.015DOI Listing

Developing spectral numerical factor technique for the determination of amlodipine besylate and the latest generation of statins in their new pharmaceutical combination.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 11;218:320-330. Epub 2019 Apr 11.

Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, Egypt. Electronic address:

Spectral numerical factor techniques have been developed for quantification of a new pharmaceutical combination. Five simple, fast and accurate spectrophotometric methods using spectral factor manipulation have been tested and validated so as to determine quantitatively a new fixed-dose combination tablet containing both amlodipine besylate (ADB) and rosuvastatin calcium (ROS). Namely, these methods are induced dual wavelength, absorbance correction, absorbance subtraction, amplitude correction and advanced amplitude subtraction. Read More

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http://dx.doi.org/10.1016/j.saa.2019.04.017DOI Listing

Muscle Mass, Density, and Strength Are Necessary to Diagnose Sarcopenia in Patients With Gastric Cancer.

J Surg Res 2019 Apr 22;241:141-148. Epub 2019 Apr 22.

Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:

Background: Accurate evaluation of muscle strength and function is difficult. Commonly known as sarcopenia, skeletal muscle loss is closely correlated with the prognosis of patients diagnosed with gastric cancer (GC). We wondered the correlation between skeletal muscle measures combined with computed tomography and grip strength (GS) and short-term outcomes after radical gastrectomy (RG) in patients with GC. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.022DOI Listing

Effect of Elective Sigmoidectomy for Diverticulitis on Bowel Function Patient-Reported Outcomes.

J Surg Res 2019 Apr 22;241:135-140. Epub 2019 Apr 22.

Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; Geisel School of Medicine, Hanover, New Hampshire. Electronic address:

Introduction: Diverticular disease is common worldwide. A subset of these patients will choose to undergo elective surgical resection because of symptoms or complicated disease. The aim of this study was to evaluate changes in bowel function after elective sigmoid resection for diverticular disease. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.041DOI Listing

The DATE Association: A Separate Entity or a Further Extension of the VACTERL Association?

J Surg Res 2019 Apr 22;241:128-134. Epub 2019 Apr 22.

Pediatric Surgery Unit, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy. Electronic address:

Background: The combination of esophageal atresia, congenital duodenal obstruction, and anorectal malformation has seldom been reported. We describe the largest series of patients with such association, which we summed up with the mnemonic acronym DATE [D-duodenal obstruction, A-anorectal malformation (ARM), and TE-tracheoesophageal fistula with esophageal atresia].

Methods: This was a multicenter retrospective review of 13 patients recruited from 8 institutions over a nearly 5-decade period (1968-2017). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193017
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http://dx.doi.org/10.1016/j.jss.2019.03.054DOI Listing
April 2019
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Open, Laparoscopic, and Robotic Inguinal Hernia Repair: Outcomes and Predictors of Complications.

J Surg Res 2019 Apr 22;241:119-127. Epub 2019 Apr 22.

Department of Surgery, University of Texas Southwestern Medical Center, Harold C. Simmons Comprehensive Cancer Center, Dallas, Texas.

Background: The robotic approach to an inguinal hernia has not been compared head to head with the open and laparoscopic techniques in randomized controlled trials. Furthermore, long-term outcomes for robotic inguinal hernia repair (RHR) are lacking. In this study, we compared laparoscopic inguinal hernia repair (LHR) and RHR with open inguinal hernia repair (OHR) in veteran patients performed by surgeons most familiar with each approach. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193016
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http://dx.doi.org/10.1016/j.jss.2019.03.046DOI Listing

Prehospital Versus Trauma Center Glasgow Coma Scale in Pediatric Traumatic Brain Injury Patients.

J Surg Res 2019 Apr 22;241:112-118. Epub 2019 Apr 22.

Department of Surgery, Nationwide Children's Hospital, Columbus, Ohio; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio; Center for Pediatric Trauma Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio. Electronic address:

Background: Traumatic brain injury (TBI) is a major source of morbidity and mortality in children. The Glasgow Coma Scale (GCS) can be challenging to calculate in pediatric patients. Our objective was to determine its reproducibility between prehospital providers and pediatric trauma hospital personnel. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.038DOI Listing

First record of characterization, concentration and distribution of microplastics in coastal sediments of an urban fjord in south west Norway using a thermal degradation method.

Chemosphere 2019 Apr 15;227:705-714. Epub 2019 Apr 15.

CNR-IRBIM, Italy.

Plastic waste is of increasing concern in the aquatic environment. A large proportion of plastic waste is generated onshore from where it eventually reaches the marine environment, which is considered the main sink of plastic debris To date there is a substantial lack of knowledge on the composition of these accumulated polymers, their environmental levels and distribution in marine and coastal areas. Current efforts are underway to develop standardized methods to characterize and quantify the occurrence of microplastic in different environmental matrices using microscopy-oriented methods using Fourier Transformed Infra-Red (FTIR) or Raman techniques. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193074
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http://dx.doi.org/10.1016/j.chemosphere.2019.04.096DOI Listing
April 2019
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Interictal dysphoric disorder of epilepsy: A continuing diagnostic challenge.

Epilepsy Behav 2019 Apr 22;95:34-38. Epub 2019 Apr 22.

Department of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Poland.

Objective: The interictal dysphoric disorder (IDD) is a proposed epilepsy-specific mood disorder characterized by a cluster of symptoms such as depressed mood, irritability, euphoria, and anxiety. Since its introduction, the concept of IDD has been a matter of debate. This study aimed to evaluate the frequency of the IDD and the association between psychiatric disorders and IDD. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.03.036DOI Listing

Unmix Optimum analysis of PAH sediment sources.

Sci Total Environ 2019 Mar 19;673:831-838. Epub 2019 Mar 19.

Civil and Environmental Engineering, University of Southern California, Los Angeles, CA 90089, United States of America.

Unmix Optimum (UnmixO) was developed to analyze data, such as sediment PAH data, that were resistant to existing methods of multivariate analysis. Using a geometrical approach, UnmixO uses multiple advanced nonlinear optimization algorithms to find potential sources that obey non-negativity constraints while optimally fitting the data. UnmixO does not require specific knowledge of the uncertainties in the data and will work better for smaller data sets than other multivariate models. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.227DOI Listing

Multisensory factors in postural control: Varieties of visual and haptic effects.

Gait Posture 2019 Apr 17;71:87-91. Epub 2019 Apr 17.

University of Maryland, College Park, United States.

Background Previous work on balance control in children and adults highlights the importance of multisensory information. Work in this vein has examined two principal input sources - the role of visual and haptic information on balance. Recent work has explored the impact of a different form of haptic input - object holding - on balance in young infants. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2019.04.018DOI Listing

The effects of textured materials on static balance in healthy young and older adults: A systematic review with meta-analysis.

Gait Posture 2019 Apr 17;71:79-86. Epub 2019 Apr 17.

School of Health and Social Care, Teesside University, Middlesbrough, UK. Electronic address:

Background: Standing on textured materials can improve static balance, potentially by modulating somatosensory inputs from the soles of the feet.

Research Question: To synthesise and quantify the immediate effects of textured materials on static balance in healthy young and older adults.

Methods: Primary outcomes were the centre of pressure (COP) displacement and velocity, during eyes open and eyes closed conditions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09666362183189
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http://dx.doi.org/10.1016/j.gaitpost.2019.04.017DOI Listing
April 2019
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A deep network for tissue microstructure estimation using modified LSTM units.

Med Image Anal 2019 Apr 18;55:49-64. Epub 2019 Apr 18.

School of Economics and Management, Beihang University, Beijing, 37 Xueyuan Road, 100191, China. Electronic address:

Diffusion magnetic resonance imaging (dMRI) offers a unique tool for noninvasively assessing tissue microstructure. However, accurate estimation of tissue microstructure described by complicated signal models can be challenging when a reduced number of diffusion gradients are used. Deep learning based microstructure estimation has recently been developed and achieved promising results. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13618415183055
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http://dx.doi.org/10.1016/j.media.2019.04.006DOI Listing
April 2019
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Expression of plasma microRNA-145-5p and its correlation with clinical features in patients with refractory epilepsy.

Epilepsy Res 2019 Apr 19;154:21-25. Epub 2019 Apr 19.

Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China. Electronic address:

Purpose: The potential of microRNAs (miRNAs) as biomarkers has been explored in various brain diseases, including epilepsy. In this study, we are aiming to analyze the aberrant expression of miRNA-145-5p in patients with refractory epilepsy, and to further explore the correlation with clinical features.

Methods: The study cohort comprised 40 patients with refractory epilepsy and 42 healthy controls. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.04.010DOI Listing

Long-term safety and efficacy of cannabidiol in children and adults with treatmentresistant Lennox-Gastaut syndrome or Dravet syndrome: Expanded access program results.

Epilepsy Res 2019 Mar 25;154:13-20. Epub 2019 Mar 25.

Oishei Children's Hospital, Buffalo, NY, USA.

Background: Since 2014, patients with severe treatment-resistant epilepsies (TREs) have been receiving add-on cannabidiol (CBD) in an ongoing, expanded access program (EAP), which closely reflects clinical practice. We conducted an interim analysis of long-term efficacy and tolerability in patients with Lennox-Gastaut syndrome (LGS) or Dravet syndrome (DS) who received CBD treatment through December 2016.

Methods: Children and adults with LGS/DS taking stable doses of antiepileptic drugs (AEDs) at baseline were included from 25 EAP sites across the United States. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.015DOI Listing

Adequacy of negative binomial models for managing safety on rural local roads.

Accid Anal Prev 2019 Apr 22;128:148-158. Epub 2019 Apr 22.

Center for Road Safety, Lyles School of Civil Engineering, Purdue University, 3000 Kent Avenue, Suite C2-103, West Lafayette, IN, 47906, United States. Electronic address:

Count models, such as negative binomial regression, are well-established statistical methods for analyzing road safety. Although count models are widely used for arterial roads, their application to rural local roads is sparse, partly due to the concern of possible estimation bias caused by low crash counts. This paper revisits the matter to further evaluate the suitability of negative binomial models for rural local roads with low crash frequencies, comparing the performance of the model to probabilistic regression (ordered probit) proposed in the past. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00014575183068
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http://dx.doi.org/10.1016/j.aap.2019.03.001DOI Listing
April 2019
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Effectiveness of school-based health center delivery of a cognitive skills building intervention in young, rural adolescents: Potential applications for addiction and mood.

J Pediatr Nurs 2019 Apr 22;47:23-29. Epub 2019 Apr 22.

University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, United States of America. Electronic address:

Purpose: Uniquely positioned, school nurses address two of the most critical adolescent health issues - addiction and mood. Cognitive behavioral therapy, the mainstay in management of adolescent mood disorders, demonstrates promise in the treatment and prevention of addictive behaviors. Quality decision-making may protect adolescents from substance abuse. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08825963193014
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http://dx.doi.org/10.1016/j.pedn.2019.04.013DOI Listing
April 2019
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Hippocampal subfield volumes and childhood trauma in bipolar disorders.

J Affect Disord 2019 Apr 10;253:35-43. Epub 2019 Apr 10.

IRCCS Santa Lucia Foundation, Laboratory of Neuropsychiatry, Rome, Italy; Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. Electronic address:

Background: Alterations in hippocampal structure and function are present in bipolar disorder (BD). Childhood trauma is associated with risk for BD, and the several subfields of the hippocampus are differentially sensitive to the effects of stressors of the sort associated with risk for BD. The current study therefore sought to test the hypothesis that childhood trauma may be differentially associated with abnormal hippocampal subfield volumes in BD. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.071DOI Listing

Teriparatide improves alveolar bone modelling after tooth extraction in orchiectomized rats.

Arch Oral Biol 2019 Apr 16;102:147-154. Epub 2019 Apr 16.

Department of Surgery and Integrated Clinic, Aracatuba Dental School, Univ. Estadual Paulista-UNESP, Aracatuba, Sao Paulo, Brazil.

Objective: The aim of this study was to evaluate bone metabolism in the alveolar repair process in orchiectomized male rats treated with teriparatide.

Materials And Methods: A total of 78 rats were divided into three groups: 26 oriectomized rats treated with teriparatide (ORQTRAT), 26 untreated orchiectomized rats (ORQ), and 26 rats which had undergone sham surgical procedures (SHAM), all these animals underwent extraction of the central incisor tooth. Thus, a histological analysis was performed (42 days). Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.04.007DOI Listing

Vertebra-disc ratio as a new predictor for curve progression in early thoracic AIS with bracing treatment.

Clin Neurol Neurosurg 2019 Apr 15;181:82-88. Epub 2019 Apr 15.

Spine Surgery, Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu Province, China. Electronic address:

Objectives: Previous studies have reported various predictors for curve progression in braced adolescent idiopathic scoliosis (AIS) patients. However, the reported predictors might be insufficient for patients with early AIS. The aim was to investigate whether the initial vertebra-disc ratio (VDR) could serve as an effective predictor for curve progression in early thoracic AIS (premenarchal and Risser 0) undergoing brace treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467193011
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http://dx.doi.org/10.1016/j.clineuro.2019.04.012DOI Listing
April 2019
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Kaempferol protects lipopolysaccharide-induced inflammatory injury in human aortic endothelial cells (HAECs) by regulation of miR-203.

Biomed Pharmacother 2019 Apr 22;115:108888. Epub 2019 Apr 22.

Hypertension Department, Henan Provincial People's Hospital, Zhengzhou, 450003, China. Electronic address:

Background/aims: Hypertension is a common public health problem due to its high morbidity and potential risk, which is related to inflammatory actions. Kaempferol (KAE) has anti-inflammation activities. Herein, we explored the effects of KAE on LPS-induced inflammatory injury in human aortic endothelial cells (HAECs). Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108888DOI Listing

Protective effect of pig brain polypeptides against corticosterone-induced oxidative stress, inflammatory response, and apoptosis in PC12 cells.

Biomed Pharmacother 2019 Apr 22;115:108890. Epub 2019 Apr 22.

Research Center of Traditional Chinese Medicine, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China. Electronic address:

Objective: Pig brain polypeptides (PBP), active polypeptides hydrolysate extracted from fresh porcine brain tissue, has been shown to have neuroprotective effects in both in vitro and in vivo studies. The present study aimed to explore the molecular mechanisms underlying the neuroprotective effects of PBP in corticosterone (CORT)-induced rat adrenal pheochromocytoma PC12 cells.

Methods: Cell viability and lactate dehydrogenase (LDH) release were measured in PC12 cells induced with 200 μM CORT in the presence or absence of various concentrations of PBP for 48 h. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322193031
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http://dx.doi.org/10.1016/j.biopha.2019.108890DOI Listing
April 2019
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Salvianolic acid B remits LPS-induced injury by up-regulating miR-142-3p in MH7A cells.

Biomed Pharmacother 2019 Apr 22;115:108876. Epub 2019 Apr 22.

Department of Rheumatology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, 223300, China.

Background: Rheumatoid arthritis (RA) is a common inflammatory disease, which significantly reduces the quality of life and increases the risk of cardiovascular and cerebrovascular diseases. The present work studied the therapeutic potency of Salvianolic acid B (Sal-B) for RA and revealed one of the possible underlying mechanisms.

Methods: Human rheumatoid fibroblast-like synoviocytes (MH7 A) were treated with Sal-B before, during or after lipopolysaccharide (LPS) stimulation. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108876DOI Listing

Flexible bioelectrodes with enhanced wrinkle microstructures for reliable electrochemical modification and neuromodulation in vivo.

Biosens Bioelectron 2019 Apr 17;135:181-191. Epub 2019 Apr 17.

National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Department of Micro/Nano Electronics, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address:

Limited electrode size with high electrochemical performance and reliability of modified materials are two of the main concerns for flexible neural electrodes in recent years. Here, an effective fabrication method of enhanced micro-scale wrinkles based on oil-pretreated hyperelastic substrates (PDMS and Ecoflex) is proposed for the application of microelectrode biosensors. Compared to pre-stretching or compressing methods, this approach has better advantages including compatibility with MEMS processes on wafer and easy replication. Read More

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http://dx.doi.org/10.1016/j.bios.2019.04.025DOI Listing

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.

Eur J Cancer 2019 Apr 22;114:27-35. Epub 2019 Apr 22.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

Purpose: Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive paediatric brain tumour with fatal outcome. The Individualised Therapy For Relapsed Malignancies In Childhood (INFORM) registry study offers comprehensive molecular profiling of high-risk tumours to identify target alterations for potential precision therapy. We analysed molecular characteristics and clinical data after brainstem biopsy of all enrolled newly diagnosed DIPGs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09598049193022
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http://dx.doi.org/10.1016/j.ejca.2019.03.019DOI Listing
April 2019
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Waterproof breathable layers - A review.

Adv Colloid Interface Sci 2019 Mar 13;268:114-135. Epub 2019 Mar 13.

Department of Chemical and Petroleum Engineering, American University of Beirut, PO Box 11-236, Beirut 1107-2020, Lebanon. Electronic address:

Waterproof breathable layers (WPBLs) can be classified into two large groups of hydrophilic nonporous and hydrophobic porous layers. These layers (e.g. Read More

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http://dx.doi.org/10.1016/j.cis.2019.03.006DOI Listing
March 2019
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