162,810 results match your criteria Methods and Findings in Experimental & Clinical Pharmacology[Journal]


Assessing the Role of Anti rh-GAA in Modulating Response to ERT in a Late-Onset Pompe Disease Cohort from the Italian GSDII Study Group.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

Department of Clinical and Experimental Medicine, UOC di Neurologia e Malattie Neuromuscolari, University of Messina, Messina, Italy.

Introduction: Patients with late-onset Pompe disease (LOPD) receiving enzyme replacement therapy (ERT) may develop IgG antibodies against alglucosidase alpha (anti-rhGAA) in the first 3 months of treatment. The exact role of these antibodies in modulating efficacy of ERT in this group of patients is still not fully understood. To assess whether anti rh-GAA antibodies interfere with ERT efficacy, we studied a large Italian cohort of LOPD patients. Read More

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http://dx.doi.org/10.1007/s12325-019-00926-5DOI Listing

Current Advancements in the Development and Characterization of Full-Thickness Adult Neuroretina Organotypic Culture Systems.

Cells Tissues Organs 2019 Mar 15:1-14. Epub 2019 Mar 15.

Retinal degenerative diseases such as macular degeneration, glaucoma, and diabetic retinopathy constitute the leading cause of blindness in the industrialized world. There is a continuous demand in investigative ophthalmic research for the development of new treatment modalities for retinal therapy. Unfortunately, efforts to identify novel neuroprotective and neuroregenerative agents have often been hindered by an experimental model gap that exists between high-throughput methods via dissociated cells and preclinical animal models. Read More

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http://dx.doi.org/10.1159/000497296DOI Listing

Intrathecal cell therapy with autologous stromal cells increases cerebral glucose metabolism and can offer a new approach to the treatment of Alzheimer's type dementia.

Cytotherapy 2019 Mar 14. Epub 2019 Mar 14.

Department of Experimental Psychology, Faculty of Psychology, Complutense University, Madrid, Spain.

Background Aims: After recent observations that intrathecal administration of autologous bone marrow mesenchymal stromal cells (MSCs) increases cerebral metabolism in patients with severe traumatic brain injury (TBI), we examined this type of cell therapy in Alzheimer's type dementia.

Methods: Three patients with clinical diagnosis of Alzheimer's disease received every 3 months 100 million autologous MSCs by intrathecal route, until a total dose of 300 million.

Results: During cell therapy the patients showed arrest in neurological deterioration and two of them manifested clear improvement of previous symptoms. Read More

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http://dx.doi.org/10.1016/j.jcyt.2019.02.009DOI Listing

Differentiated Thyroid Cancer in Children: A UK Multicentre Review and Review of the Literature.

Clin Oncol (R Coll Radiol) 2019 Mar 14. Epub 2019 Mar 14.

Royal Marsden NHS Foundation Trust Thyroid Unit, London, UK.

Aims: To obtain an overview of the management and outcomes of children aged 18 years or younger diagnosed with differentiated thyroid carcinoma of follicular cell origin across the UK, by collecting and analysing data from the limited number of centres treating these patients. This multicentre data might provide a more realistic perspective than single-institution series.

Materials And Methods: Six centres submitted data extracted from historical records on patients aged 18 years or younger, diagnosed between 1964 and 2017. Read More

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http://dx.doi.org/10.1016/j.clon.2019.02.005DOI Listing

The effectiveness of curvilinear supine position on the incidence of pressure injuries and interface pressure among surgical patients.

J Tissue Viability 2019 Feb 25. Epub 2019 Feb 25.

TongJi Hospital, TongJi Medical College, Huazhong University of Science and Technology, China. Electronic address:

Background: Intraoperative pressure injury is still a major problem of perioperative nursing. Reducing the peak interface pressure is a valid clinical intervention for reducing the incidence of intraoperative pressure injuries. However, studies of repositioning and pressure-redistributing for surgical patients are still lacking. Read More

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http://dx.doi.org/10.1016/j.jtv.2019.02.005DOI Listing
February 2019

Malignancies associated with GIST: a retrospective study with molecular analysis of KIT and PDGFRA.

Langenbecks Arch Surg 2019 Mar 15. Epub 2019 Mar 15.

Department of Pathology, FAU Erlangen-Nürnberg, Erlangen, Germany.

Purpose: Gastrointestinal stromal tumors (GISTs) are the most common soft tissue tumors of the GI tract. Studies have been published reporting additional neoplasms in GIST patients. This study aimed to evaluate possible associations of mutation type, morphology, and clinical aspects of GISTs. Read More

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http://dx.doi.org/10.1007/s00423-019-01773-2DOI Listing

The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic.

Exp Eye Res 2019 Mar 12. Epub 2019 Mar 12.

Centre for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom. Electronic address:

Purpose: Retinal ischemia remains a common sight threatening end-point in blinding diseases such as diabetic retinopathy and retinopathy of prematurity. Endothelial colony forming cells (ECFCs) represent an attractive therapeutic subpopulation of endothelial progenitor cells for promoting reparative angiogenesis in the ischaemic retina. The current study has investigated the potential of enhancing this cell therapy approach by the dampening of the pro-inflammatory milieu typical of ischemic retina. Read More

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http://dx.doi.org/10.1016/j.exer.2019.03.001DOI Listing

Proteomic analysis of tear fluid reveals disease-specific patterns in patients with Parkinson's disease - A pilot study.

Parkinsonism Relat Disord 2019 Mar 6. Epub 2019 Mar 6.

Department of Neurology, University Medical Center Göttingen, Göttingen, Germany; Deutsche Forschungsgemeinschaft - German Research Center for Nanoscale Microscopy and Molecular Physiology of the Brain, Göttingen, Germany; Klinikum Rechts der Isar der Technischen Universität München, Munich, Germany. Electronic address:

Background: The diagnosis of Parkinson's disease (PD) is still challenging and biomarkers could contribute to an improved diagnostic accuracy. Tear fluid (TF) is an easily accessible body fluid reflecting pathophysiological changes in systemic and ocular diseases and is already used as a biomarker source for several ophthalmological disorders. Here, we analyzed the TF of patients with PD and controls (CTR) to describe disease-related changes in TF and identify putative biomarkers for the diagnosis of PD. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.03.001DOI Listing
March 2019
1 Read

Oculo-Facio-Cardio-Dental Syndrome: A Case Report about a Rare Pathological Condition.

Int J Environ Res Public Health 2019 Mar 14;16(6). Epub 2019 Mar 14.

Institute of Endodontics, Institute of Integrated Clinical Practice, Institute of Experimental Pathology,Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology(CIMAGO), CNC.IBILI, Faculty of Medicine, University of Coimbra, Avenida Bissaya Barreto,3000-075 Coimbra, Portugal.

(1) Background: Oculo-facio-cardio-dental (OFCD) syndrome is a rare pathological condition with an X-linked dominant trait that only occurs in females; no males are born with OFCD syndrome. This syndrome is characterized by congenital cataracts with secondary glaucoma ocular defects, ventricular and atrial septal defects, or mitral valve prolapses. Facial traits are a long narrow face and a high nasal bridge with a bifid nasal tip. Read More

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http://dx.doi.org/10.3390/ijerph16060928DOI Listing

Current and Potential Roles in Sports Pharmacy: A Systematic Review.

Pharmacy (Basel) 2019 Mar 14;7(1). Epub 2019 Mar 14.

Faculty of Health and Medicine, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan 2308, Australia.

(1) : The objective of this systematic review was to evaluate current and potential roles for pharmacists in sports medicine and to identify key themes in outcomes reported in studies. (2) : EMBASE, MEDLINE, CINAHL, Scopus and the Cochrane Library were searched in January 2019. Peer-reviewed, original research articles were considered for inclusion. Read More

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https://www.mdpi.com/2226-4787/7/1/29
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http://dx.doi.org/10.3390/pharmacy7010029DOI Listing
March 2019
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To be or not to be: PP2A as a dual player in CNS functions, its role in neurodegeneration, and its interaction with brain insulin signaling.

Cell Mol Life Sci 2019 Mar 14. Epub 2019 Mar 14.

Department of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Accumulating evidence has reached the consensus that the balance of phosphorylation state of signaling molecules is a pivotal point in the regulation of cell signaling. Therefore, characterizing elements (kinases-phosphatases) in the phosphorylation balance are at great importance. However, the role of phosphatase enzymes is less investigated than kinase enzymes. Read More

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http://dx.doi.org/10.1007/s00018-019-03063-yDOI Listing

Endocrine Therapy-Related Symptoms and Quality of Life in Female Cancer Survivors in the Yale Fitness Intervention Trial.

J Nurs Scholarsh 2019 Mar 15. Epub 2019 Mar 15.

Research Scientist in Nursing, Yale University School of Nursing, Orange, CT,, USA.

Purpose: The aim of the current study was to describe and compare endocrine therapy-related symptoms and quality of life in female cancer survivors taking aromatase inhibitors, tamoxifen, and no endocrine therapy, and to evaluate the effect of an exercise intervention on these symptoms and quality of life.

Design: Randomized controlled trial. An aerobic resistance exercise intervention group was compared with a home-based exercise control group over 1 year. Read More

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http://dx.doi.org/10.1111/jnu.12471DOI Listing

Neonatal circumcision and prematurity are associated with sudden infant death syndrome (SIDS).

Authors:
Eran Elhaik

J Clin Transl Res 2019 Jan 9;4(2):136-151. Epub 2019 Jan 9.

Department of Animal and Plant Sciences, University of Sheffield, UK.

Background: Sudden infant death syndrome (SIDS) is the most common cause of postneonatal unexplained infant death. The allostatic load hypothesis posits that SIDS is the result of cumulative perinatal painful, stressful, or traumatic exposures that tax neonatal regulatory systems.

Aims: To test the predictions of the allostatic load hypothesis we explored the relationships between SIDS and two common phenotypes, male neonatal circumcision (MNC) and prematurity. Read More

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January 2019

Self-reported impulsivity in women with borderline personality disorder: the role of childhood maltreatment severity and emotion regulation difficulties.

Borderline Personal Disord Emot Dysregul 2019 5;6. Epub 2019 Mar 5.

Department of Clinical Psychology, Institute of Psychology, Leiden, The Netherlands.

Background: Childhood maltreatment, such as severe emotional, physical, and sexual abuse and neglect, has been linked to impulse control problems and dysfunctional emotional coping. In borderline personality disorder (BPD), a history of childhood maltreatment may worsen difficulties in emotion regulation, which may in turn give rise to impulsive behaviours. The aim of this self-report study was to investigate associations between childhood maltreatment severity, emotion regulation difficulties, and impulsivity in women with BPD compared to healthy and clinical controls. Read More

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http://dx.doi.org/10.1186/s40479-019-0101-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399941PMC

Preserve encephalus in surgery of trauma: online survey. (P.E.S.T.O).

World J Emerg Surg 2019 4;14. Epub 2019 Mar 4.

11Department of Emergency Surgery, Parma University Hospital, Parma, Italy.

Background: Traumatic brain injury (TBI) is a global health problem. Extracranial hemorrhagic lesions needing emergency surgery adversely affect the outcome of TBI. We conducted an international survey regarding the acute phase management practices in TBI polytrauma patients. Read More

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http://dx.doi.org/10.1186/s13017-019-0229-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399949PMC

The Effects of Combined Low Frequency Repetitive Transcranial Magnetic Stimulation and Motor Imagery on Upper Extremity Motor Recovery Following Stroke.

Front Neurol 2019 19;10:96. Epub 2019 Feb 19.

Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

To investigate the effects of low frequency transcranial magnetic stimulation (LF-rTMS) combined with motor imagery (MI) on upper limb motor function during stroke rehabilitation. Hemiplegic upper extremity activity obstacle is a common movement disorder after stroke. Compared with a single intervention, sequential protocol or combination of several techniques has been proven to be better for alleviating motor function disorder. Read More

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http://dx.doi.org/10.3389/fneur.2019.00096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401593PMC
February 2019

Couples Dealing With Pediatric Blood Cancer: A Study on the Role of Dyadic Coping.

Front Psychol 2019 27;10:402. Epub 2019 Feb 27.

Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.

Pediatric cancer is a life-threatening disease that poses significant challenges to the ill child and his/her parents. Among the studies investigating risk and protective factors for the individual and relationship adjustment of parents being confronted with pediatric cancer, couple factors - such as dyadic coping - gained little research attention. Therefore, the aim of the current study was to explore the association between dyadic coping and individual/relationship outcomes of parents in the context of pediatric cancer. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400881PMC
February 2019

Identification of Key Genes and Pathways in Post-traumatic Stress Disorder Using Microarray Analysis.

Front Psychol 2019 27;10:302. Epub 2019 Feb 27.

School of First Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Post-traumatic stress disorder (PTSD) is characterized by impaired fear extinction, excessive anxiety, and depression. However, the potential pathogenesis and cause of PTSD are not fully understood. Hence, the purpose of this study was to identify key genes and pathway involved in PTSD and reveal underlying molecular mechanisms by using bioinformatics analysis. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403462PMC
February 2019

A Systematic Review of Integrated Functional Near-Infrared Spectroscopy (fNIRS) and Transcranial Magnetic Stimulation (TMS) Studies.

Front Neurosci 2019 28;13:84. Epub 2019 Feb 28.

Drexel University, School of Biomedical Engineering, Science and Health Systems, Philadelphia, PA, United States.

The capacity for TMS to elicit neural activity and manipulate cortical excitability has created significant expectation regarding its use in both cognitive and clinical neuroscience. However, the absence of an ability to quantify stimulation effects, particularly outside of the motor cortex, has led clinicians and researchers to pair noninvasive brain stimulation with noninvasive neuroimaging techniques. fNIRS, as an optical and wearable neuroimaging technique, is an ideal candidate for integrated use with TMS. Read More

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https://www.frontiersin.org/article/10.3389/fnins.2019.00084
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http://dx.doi.org/10.3389/fnins.2019.00084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403189PMC
February 2019
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MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort.

Lancet Child Adolesc Health 2019 Mar 11. Epub 2019 Mar 11.

Molecular and Pharmaco-Epidemiology Unit, Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy. Electronic address:

Background: Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls.

Methods: In this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, Serbia, Spain, Sweden, Turkey, and the USA) to assemble an international multicentre cohort. Read More

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http://dx.doi.org/10.1016/S2352-4642(19)30005-7DOI Listing

Denoising of low-dose CT images via low-rank tensor modeling and total variation regularization.

Artif Intell Med 2019 Mar 31;94:1-17. Epub 2018 Dec 31.

Department of Electronics & Communication Engineering, National Institute of Technology Calicut, India.

Low-dose Computed Tomography (CT) imaging is a most commonly used medical imaging modality. Though the reduction in dosage reduces the risk due to radiation, it leads to an increase in noise level. Hence, it is a mandatory requirement to include a noise reduction technique as a pre- and/or post-processing step for better disease diagnosis. Read More

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http://dx.doi.org/10.1016/j.artmed.2018.12.006DOI Listing

Effects of duodenal transection timing on clinical short-term outcomes of patients with laparoscopic spleen-preserving splenic hilar lymphadenectomy for advanced proximal gastric cancer.

World J Surg Oncol 2019 Mar 14;17(1):49. Epub 2019 Mar 14.

Department of Minimally Invasive Surgery, The Affiliated Hospital of Putian University, 999 Dongzhen East Rd, Putian, 351100, Fujian, China.

Background: To determine the optimal timing of duodenal transection in patients undergoing laparoscopic-assisted total gastrectomy (LATG) in combination with laparoscopic spleen-preserving splenic hilar lymphadenectomy (LSPL) for advanced proximal gastric cancer (APGC).

Methods: One hundred twenty-seven patients with APGC who received LATG with duodenal transection as well as LSPL between January 2017 and July 2018 were retrospectively recruited in this study. According to the different transection timing, the patients were allocated into two groups: a conventional group (CG) who received the duodenal transection prior to the LSPL and an experimental group (EG) who were given LSPL before the duodenum was transected. Read More

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http://dx.doi.org/10.1186/s12957-019-1590-zDOI Listing
March 2019
1.200 Impact Factor

Computational Approaches in Theranostics: Mining and Predicting Cancer Data.

Pharmaceutics 2019 Mar 13;11(3). Epub 2019 Mar 13.

Coimbra Chemistry Centre, Department of Chemistry, Faculty of Sciences and Technology, University of Coimbra, 3004-535 Coimbra, Portugal.

The ability to understand the complexity of cancer-related data has been prompted by the applications of (1) computer and data sciences, including data mining, predictive analytics, machine learning, and artificial intelligence, and (2) advances in imaging technology and probe development. Computational modelling and simulation are systematic and cost-effective tools able to identify important temporal/spatial patterns (and relationships), characterize distinct molecular features of cancer states, and address other relevant aspects, including tumor detection and heterogeneity, progression and metastasis, and drug resistance. These approaches have provided invaluable insights for improving the experimental design of therapeutic delivery systems and for increasing the translational value of the results obtained from early and preclinical studies. Read More

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https://www.mdpi.com/1999-4923/11/3/119
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http://dx.doi.org/10.3390/pharmaceutics11030119DOI Listing
March 2019
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How to modify persisting negative expectations in major depression? An experimental study comparing three strategies to inhibit cognitive immunization against novel positive experiences.

J Affect Disord 2019 Mar 6;250:231-240. Epub 2019 Mar 6.

Department of Clinical Psychology and Psychotherapy, Philipps-University of Marburg, Gutenbergstraße 18, D-35032 Marburg, Germany.

Background: Research has shown that negative expectations in major depressive disorder (MDD) often persist despite positive disconfirming experiences. To explain this phenomenon, the concept of cognitive immunization has been introduced: that is, individuals with MDD reappraise disconfirming positive evidence in such a way that negative expectations are maintained. In this study, we examined whether it is possible to inhibit cognitive immunization to facilitate expectation update. Read More

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http://dx.doi.org/10.1016/j.jad.2019.03.027DOI Listing

Neurosurgical contribution within a complex NF1 supraregional service.

Clin Neurol Neurosurg 2019 Mar 4;180:18-24. Epub 2019 Mar 4.

Department of Neurosurgery, Greater Manchester Neurosciences Centre, Salford Royal NHS Foundation Trust, Manchester Academic Health Sciences Centre, Salford, Greater Manchester, UK; Division of Neuroscience & Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Objectives: The goal of this study was to review and present neurosurgical related activity within a multidisciplinary nationally commissioned specialty neurofibromatosis type I (NF1) center.

Patients & Methods: We reviewed all NF1 Neurosurgical MDTs, NF1 Neurosurgical clinics and all neurosurgical procedures carried out in NF1 patients over an 8-year period.

Results: Since the inception of the service in 2009, 1505 cases were discussed at our NF-1 multidisciplinary meeting, 171 clinic appointments in complex NF1 patients with neurosurgical pathologies and 43(cranial and spinal) operations were performed. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.03.002DOI Listing

Incidence and prevalence of falls in adults with intellectual disability living in the community: a systematic review.

JBI Database System Rev Implement Rep 2019 Mar;17(3):390-413

School of Physiotherapy and Exercise Science, Curtin University, Perth, Australia.

Objective: The objective of the review was too synthesize the best available evidence on the incidence and prevalence of falls among adults with intellectual disability (ID).

Introduction: Falls among adults with ID frequently cause physical injury and may negatively impact on their quality of life. Studies investigating falls among people with ID have used differing methods and populations, making it difficult to determine the scope and extent of this problem. Read More

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http://dx.doi.org/10.11124/JBISRIR-2017-003798DOI Listing

Effectiveness of dietary inorganic nitrate for lowering blood pressure in hypertensive adults: a systematic review.

JBI Database System Rev Implement Rep 2019 Mar;17(3):365-389

School of Nursing, University of Mississippi Medical Center, USA.

Objective: The objective of this review was to evaluate the effectiveness of inorganic nitrate on blood pressure in hypertensive adults.

Introduction: Hypertension is associated with increased risk of morbidity and mortality in adults. Inorganic nitrate could be beneficial for lowering blood pressure and reducing cardiovascular disease risks. Read More

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http://dx.doi.org/10.11124/JBISRIR-2017-003842DOI Listing

The effects of divided attention and of stimulus repetition on item-item binding in verbal working memory.

J Exp Psychol Learn Mem Cogn 2019 Mar 14. Epub 2019 Mar 14.

Department of Psychological Sciences.

An unresolved issue regarding working memory (WM) processes relates to whether domain-general attentional resources are required to form and store bound representations. Recent evidence suggests that visual WM performance during tasks that require binding of face-scene pairs is disrupted by concurrent divided attention to a greater degree than when needing to remember only faces or scenes (Peterson & Naveh-Benjamin, 2017). These findings contrast with associative long-term memory (LTM) studies, which have found no differential impact of divided attention on associative relative to item memory (Naveh-Benjamin, Guez, & Marom, 2003). Read More

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http://dx.doi.org/10.1037/xlm0000698DOI Listing

Observations on the Mechanochemical Insertion of Zinc(II), Copper(II), Magnesium(II), and Select Other Metal(II) Ions into Porphyrins.

Inorg Chem 2019 Mar 14. Epub 2019 Mar 14.

Department of Chemistry , University of Connecticut , Unit 3060 , Storrs , Connecticut 06269-3060 , United States.

Building on a proof of concept study that showed the possibility of the mechanochemical insertion of some M(II) metals into meso-tetraphenylporphyrin using a ball mill as an alternative to traditional solution-based methods, we present here a detailed study of the influence of the many experimental variables on the reaction outcome performed in a planetary mill. Using primarily the mechanochemical zinc, copper, and magnesium insertion reactions, the scope and limits of the type of porphyrins (electron-rich or electron-poor meso-tetraarylporphyrins, synthetic or naturally occurring octaalkylporphyrins, and meso-triphenylcorrole) and metal ion sources suitable for this metal insertion modality were determined. We demonstrate the influence of the experimental metal insertion parameters, such as ball mill speed and reaction time, and investigated the often surprising roles of a variety of grinding agents. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00052DOI Listing

Effect of environmental and pharmaceutical exposures on fetal testis development and function: a systematic review of human experimental data.

Hum Reprod Update 2019 Mar 14. Epub 2019 Mar 14.

MRC Centre for Reproductive Health, The University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, UK.

Background: Overall, the incidence of male reproductive disorders has increased in recent decades. Testicular development during fetal life is crucial for subsequent male reproductive function. Non-genomic factors such as environmental chemicals, pharmaceuticals and lifestyle have been proposed to impact on human fetal testicular development resulting in subsequent effects on male reproductive health. Read More

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https://academic.oup.com/humupd/advance-article/doi/10.1093/
Publisher Site
http://dx.doi.org/10.1093/humupd/dmz004DOI Listing
March 2019
1 Read

Statistical Analysis on Threshold of Haemoglobin A1C (HBA1c) for Diabetes Diagnosis and the Relationship Between HBA1c and Plasma Glucose Concentrations in Chinese Diabetic High-Risk Groups.

Clin Lab 2019 Mar;65(3)

Background: The goal is to evaluate the threshold of hemoglobin A1C (HBA1c) for screening test among Chinese patients with diabetes and high-risk groups in the endocrinological department and identify the relationship between HbA1c and plasma glucose.

Methods: Experimental design: This study is based on the data selected from patients without clinical intervention enrolled in the Endocrinology Department and Admission Office in our hospital. It uses the four-point plasma glucose modeling and trapezoidal integration method to analyze the relationship between HbA1c and each plasma glucose threshold in an oral glucose tolerance test (OGTT). Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180711DOI Listing

Effects of Dementia Care Mapping on well-being and quality of life of older people with intellectual disability: A quasi-experimental study.

J Appl Res Intellect Disabil 2019 Mar 13. Epub 2019 Mar 13.

Department of Health Sciences, Community & Occupational Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: The ageing of people with intellectual disability, accompanied with consequences like dementia, challenges intellectual disability-care staff and creates a need for supporting methods, with Dementia Care Mapping (DCM) as a promising possibility. This study examined the effect of DCM on the quality of life of older people with intellectual disability.

Methods: We performed a quasi-experimental study in 23 group homes for older people with intellectual disability in the Netherlands, comparing DCM (n = 113) with care-as-usual (CAU; n = 111). Read More

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http://doi.wiley.com/10.1111/jar.12576
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http://dx.doi.org/10.1111/jar.12576DOI Listing
March 2019
1 Read

Tanshinone IIA protects against lipopolysaccharide-induced lung injury through targeting Sirt1.

J Pharm Pharmacol 2019 Mar 13. Epub 2019 Mar 13.

Institute of Translational Medicine, Nanchang University, Nanchang, China.

Objectives: This study was designed to investigate the effects and the mechanism of Tanshinone IIA (TIIA) on endotoxic shock-induced lung injury in a mouse model.

Methods: Mice were administered intraperitoneally with TIIA (10 mg/kg) 0.5 h before lipopolysaccharide (LPS) challenge and then received additional injections every 24 h during the 3-day experimental period. Read More

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http://dx.doi.org/10.1111/jphp.13087DOI Listing

Inactivation of apaziquone by haematuria: implications for the design of phase III clinical trials against non-muscle invasive bladder cancer.

Cancer Chemother Pharmacol 2019 Mar 13. Epub 2019 Mar 13.

Spectrum Pharmaceuticals Inc, Irvine, CA, USA.

Purpose: Despite positive responses in phase II clinical trials, the bioreductive prodrug apaziquone failed to achieve statistically significant activity in non-muscle invasive bladder cancer in phase III trials. Apaziquone was administered shortly after transurethral resection and here we test the hypothesis that haematuria inactivates apaziquone.

Methods: HPLC analysis was used to determine the ability of human whole blood to metabolise apaziquone ex vivo. Read More

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http://dx.doi.org/10.1007/s00280-019-03812-7DOI Listing

A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine.

Epilepsia Open 2019 Mar 17;4(1):102-109. Epub 2019 Jan 17.

Molecular and Cellular Therapeutics Royal College of Surgeons in Ireland Dublin Ireland.

Objective: To ascertain the clinical and genetic factors contributing to carbamazepine- and oxcarbazepine-induced hyponatremia (COIH), and to carbamazepine (CBZ) metabolism, in a retrospectively collected, cross-sectional cohort of people with epilepsy.

Methods: We collected data on serum sodium levels and antiepileptic drug levels in people with epilepsy attending a tertiary epilepsy center while on treatment with CBZ or OXC. We defined hyponatremia as Na+ ≤134 mEq/L. Read More

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http://dx.doi.org/10.1002/epi4.12297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398103PMC
March 2019
1 Read

Modulating pain thresholds through classical conditioning.

PeerJ 2019 8;7:e6486. Epub 2019 Mar 8.

Research Centre for Health Psychology, KU Leuven, Leuven, Belgium.

Background: Classical conditioning has frequently been shown to be capable of evoking fear of pain and avoidance behavior in the context of chronic pain. However, whether pain itself can be conditioned has rarely been investigated and remains a matter of debate. Therefore, the present study investigated whether pain threshold ratings can be modified by the presence of conditioned non-nociceptive sensory stimuli in healthy participant. Read More

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https://peerj.com/articles/6486
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http://dx.doi.org/10.7717/peerj.6486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410694PMC
March 2019
1 Read

Nrf2 signaling and inflammation are key events in physical plasma-spurred wound healing.

Theranostics 2019 30;9(4):1066-1084. Epub 2019 Jan 30.

Leibniz-Institute for Plasma Science and Technology (INP Greifswald), Plasma Life Science and ZIK plasmatis, Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.

Wound healing is strongly associated with the presence of a balanced content of reactive species in which oxygen-dependent, redox-sensitive signaling represents an essential step in the healing cascade. Numerous studies have demonstrated that cold physical plasma supports wound healing due to its ability to deliver a beneficial mixture of reactive species directly to the cells. : We described a preclinical proof-of-principle-concept of cold plasma use in a dermal, full-thickness wound model in immunocompetent SKH1 mice. Read More

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http://dx.doi.org/10.7150/thno.29754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401410PMC
January 2019

Increased Perceptual and Motor Performance of the Arms of Elite Water Polo Players.

Appl Bionics Biomech 2019 5;2019:6763470. Epub 2019 Feb 5.

Faculty for Sport and Physical Education, University of Montenegro, Niksic 81400, Montenegro.

Background: It has been stated that long-term participation in sport training can influence the motor asymmetry of the arms with a decreased interlimb difference. However, whether this pattern is observable in different sports and with different variables, like perceptual performance, still needs to be tested. Therefore, we investigated if long-term sports participation might modify the motor and perceptual performance asymmetries of arms in water polo players. Read More

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http://dx.doi.org/10.1155/2019/6763470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379865PMC
February 2019

The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells.

J Am Soc Nephrol 2019 Mar 13. Epub 2019 Mar 13.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany;

Background: RNA-binding proteins (RBPs) are fundamental regulators of cellular biology that affect all steps in the generation and processing of RNA molecules. Recent evidence suggests that regulation of RBPs that modulate both RNA stability and translation may have a profound effect on the proteome. However, regulation of RBPs in clinically relevant experimental conditions has not been studied systematically. Read More

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http://dx.doi.org/10.1681/ASN.2018090914DOI Listing

Indoor residual spray bio-efficacy and residual activity of a clothianidin-based formulation (SumiShield 50WG) provides long persistence on various wall surfaces for malaria control in the Democratic Republic of the Congo.

Malar J 2019 Mar 12;18(1):72. Epub 2019 Mar 12.

China Molybdenum Co., Ltd./International SOS Malaria Control Programme, Tenke Fungurume Mining, Fungurume, Lualaba Province, Democratic Republic of the Congo.

Background: Bio-efficacy and residual activity of SumiShield 50WG (50%, w/w) with active ingredient clothianidin, a neonicotinoid compound, was assessed using an insecticide-susceptible laboratory strain of Anopheles arabiensis. Implications of the findings are examined in the context of potential alternative insecticides for indoor residual spraying in Lualaba Province, Democratic Republic of the Congo.

Methods: Contact surface bioassays were conducted for 48 weeks on four types of walls (unbaked clay, baked clay, cement, painted cement) in simulated semi-field experimental conditions using two different doses of clothianidin active ingredient (200 mg ai/sq m and 300 mg ai/sq m). Read More

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http://dx.doi.org/10.1186/s12936-019-2710-5DOI Listing

Evaluation of the temperature of posterior lower limbs skin during the whole body vibration measured by infrared thermography: Cross-sectional study analysis using linear mixed effect model.

PLoS One 2019 13;14(3):e0212512. Epub 2019 Mar 13.

Programa de Pós-Graduação em Fisiopatologia Clínica e Experimental, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Whole body vibration exercise (WBVE) has been shown to improve muscular strength and power, and increase peripheral blood flow. The aim of this study was to evaluate the behavior of the skin temperature (Tsk) on regions of the lower limbs from an acute bout of WBVE.

Methods And Findings: Cross-sectional study approved by local ethics committee (Certificado de Apresentação para Apreciação Ética-CAAE-19826413. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212512PLOS
March 2019
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Computerised cognitive training for preventing dementia in people with mild cognitive impairment.

Cochrane Database Syst Rev 2019 Mar 13;3:CD012279. Epub 2019 Mar 13.

Centre for Healthy Brain Ageing (CHeBA), University of New South Wales, Suite 407 185 Elizabeth Street, Sydney, NSW, Australia, 2000.

Background: The number of people living with dementia is increasing rapidly. Clinical dementia does not develop suddenly, but rather is preceded by a period of cognitive decline beyond normal age-related change. People at this intermediate stage between normal cognitive function and clinical dementia are often described as having mild cognitive impairment (MCI). Read More

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http://doi.wiley.com/10.1002/14651858.CD012279.pub2
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http://dx.doi.org/10.1002/14651858.CD012279.pub2DOI Listing
March 2019
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Regulation of GLUT4 translocation in an in vitro cell model using postprandial human serum ex vivo.

Exp Physiol 2019 Mar 13. Epub 2019 Mar 13.

Food for Health Ireland, University College Dublin, Dublin, Ireland.

New Findings: What is the research question? This study employed a novel experimental model in which culture media is conditioned with human serum ex vivo to investigate nutrient-mediated regulation of GLUT4 translocation in skeletal muscle cells in vitro. What is the main finding and importance? Human serum stimulated GLUT4 translocation, an effect differentially modulated by whether the culture media is conditioned with fasted serum, or serum collected after feeding of intact or hydrolysed whey protein. Conditioning cell culture media with human serum ex vivo represents a new approach to elucidate the effects of ingesting specific nutrients on skeletal muscle cell metabolism. Read More

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http://dx.doi.org/10.1113/EP087356DOI Listing
March 2019
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Cardiac 123I-MIBG Scintigraphy in Neurodegenerative Parkinson Syndromes: Performance and Pitfalls in Clinical Practice.

Front Neurol 2019 26;10:152. Epub 2019 Feb 26.

Movement Disorders and Neuromodulation Section, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Cardiac [I]metaiodobenzylguanidine scintigraphy (123I-MIBG), reflecting postganglionic cardiac autonomic denervation, is proposed for early detection of Parkinson's disease (PD; reduced tracer uptake) and separation from Multiple System Atrophy (MSA; preserved tracer uptake). However, several recent studies report on frequent unexpected 123I-MIBG results in PD and MSA. We sought to determine, whether 123I-MIBG is feasible to discriminate PD from MSA in unselected geriatric patients in clinical practice. Read More

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http://dx.doi.org/10.3389/fneur.2019.00152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399127PMC
February 2019

Systemic exposure to a single dose of ferucarbotran aggravates neuroinflammation in a murine model of experimental autoimmune encephalomyelitis.

Int J Nanomedicine 2019 15;14:1229-1240. Epub 2019 Feb 15.

Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan,

Background: Medicinal preparations of iron oxide nanoparticles (IONPs) have been used as MRI contrast agents for the diagnosis of hepatic tumors and the assessment of neuroinflammation and blood-brain barrier integrity. However, it remains mostly unclear whether exposure to IONPs affects neuroinflammation under disease conditions. The present study aims to investigate the impact of IONPs on autoimmune-mediated neuroinflammation using a murine model of experimental autoimmune encephalomyelitis (EAE) that mimics human multiple sclerosis. Read More

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http://dx.doi.org/10.2147/IJN.S189327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391144PMC
February 2019

Cerebrospinal Fluid Spermidine, Glutamine and Putrescine Predict Postoperative Delirium Following Elective Orthopaedic Surgery.

Sci Rep 2019 Mar 12;9(1):4191. Epub 2019 Mar 12.

Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, 8 Malone Road, Belfast, BT9 5BN, Northern Ireland.

Delirium is a marker of brain vulnerability, associated with increasing age, pre-existing cognitive impairment and, recently, cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease. This nested case-control study used a targeted quantitative metabolomic methodology to profile the preoperative CSF of patients (n = 54) who developed delirium following arthroplasty (n = 28) and those who did not (n = 26). The aim was to identify novel preoperative markers of delirium, and to assess potential correlations with clinical data. Read More

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http://dx.doi.org/10.1038/s41598-019-40544-3DOI Listing

Enhanced fatty acid scavenging and glycerophospholipid metabolism accompanies melanocyte neoplasia progression in zebrafish.

Cancer Res 2019 Mar 12. Epub 2019 Mar 12.

Faculty of Biology, Medicine, and Health, School of Biological Sciences, University of Manchester

Alterations in lipid metabolism in cancer cells impact cell structure, signaling, and energy metabolism, making lipid metabolism a potential diagnostic marker and therapeutic target. In this study, we combined positron emission tomography (PET), desorption electrospray ionisation-mass spectrometry (DESI-MS), non-imaging MS, and transcriptomic analyses to interrogate changes in lipid metabolism in a transgenic zebrafish model of oncogenic RAS-driven melanocyte neoplasia progression. Exogenous fatty acid uptake was detected in melanoma tumor nodules by PET using the palmitic acid surrogate tracer 14(R,S)-18F-fluoro-6-thia-heptadecanoic acid ([18F]-FTHA), consistent with upregulation of genes associated with fatty acid uptake found through microarray analysis. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2409DOI Listing

Warburg Effect Inversion: Adiposity shifts central primary metabolism in MCF-7 breast cancer cells.

Life Sci 2019 Mar 9. Epub 2019 Mar 9.

School of Health, Polytechnic of Porto (ESS/P.PORTO), Porto, Portugal; Institute for Research and Innovation in Health (I3S), University of Porto, Portugal; Faculty of Medicine, University of Santiago de Compostela, Galiza, Spain. Electronic address:

Aims: Obesity is a complex health disorder and a trigger to many diseases like Diabetes mellitus (DM) and breast cancer (BrCa), both leading causes of morbidity and mortality worldwide. Also evidence demonstrates that abnormal glucose metabolism termed 'the Warburg effect' in cancer cell is closely associated with malignant phenotypes and promote the aggressiveness of several types of cancer, including BrCa. In this study, we evaluated the breast cancer cell metabolism in normoglycemia, hyperglycemia and in an obesity condition in order to clarify the potential underlined mechanisms that link these disorders. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.03.016DOI Listing

Urinary exosomal shuttle RNA: Promising cancer diagnosis biomarkers of lower urinary tract.

Int J Biol Markers 2019 Mar 13:1724600819827023. Epub 2019 Mar 13.

1 Institutional BioBank, Experimental Oncology and Biobank Management Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italia.

Background:: Prostate and bladder cancers continue to be the first and fourth most common cancers in men worldwide; thus there is an urgent need for more accurate biomarkers that can detect these types of cancer in a non-invasive way. Liquid biopsy is a new non-invasive tool for diagnosis and with a virtually unlimited supply urine is even more attractive resource since urinary exosomes have been discovered to contain RNAs that are hallmarks of cancer. It is challenging to assay those secreting lower amounts of molecules. Read More

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http://dx.doi.org/10.1177/1724600819827023DOI Listing