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Inorg Chem 2019 Apr 19. Epub 2019 Apr 19.

Schulich Faculty of Chemistry , Technion-Israel Institute of Technology , Haifa 32000 , Israel.

An eight-member series of CF-substituted difluorophosphorus corroles was prepared for establishing a structure-activity profile of these high-potential photosensitizers. It consisted of preparing all four possible isomers of the monosubstituted corrole and complexes with 2-, 3-, 4-, and 5-CF groups on the macrocycle's periphery. The synthetic pathway to these CF-substituted derivatives, beginning with (tpfc)PF, involves two different initial routes: (i) direct electrophilic CF incorporation using FSOCFCOMe and copper iodide, or (ii) bromination to achieve the 2,3,8,17,18-pentabrominated compound using excess bromine in methanol. Read More

Environ Monit Assess 2019 Apr 17;191(5):287. Epub 2019 Apr 17.

Department of Chemistry, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran.

Solvent-terminated dispersive liquid-liquid microextraction (ST-DLLME) as a simple, fast, and low-cost technique was developed for simultaneous extraction of Cd and Cu ions in aqueous solutions. Multiobjective evolutionary algorithm based on decomposition with the aid of artificial neural networks (ANN-MOEA/D) was used for the first time in chemistry, environment, and food sciences to optimize several independent variables affecting the extraction efficiency, including disperser volume and extraction solvent volume, pH, and salt addition. To perform the ST-DLLME operations, xylene, methanol, and dithizone were utilized as an extraction solvent, disperser solvent, and chelating agent, respectively. Read More

Evid Based Complement Alternat Med 2019 14;2019:3245836. Epub 2019 Mar 14.

Food and Science Technology Research Centre, MARDI, Serdang, Selangor, Malaysia.

Coronary artery disease is the leading cause of mortality and morbidity worldwide. The pathogenesis is mainly due to atherosclerosis, plaque rupture, and platelet thrombus formation. The main risk factors for coronary artery disease include obesity, hypercholesterolemia, smoking, diabetes, and high blood pressure. Read More

Food Res Int 2019 Jun 18;120:776-783. Epub 2018 Nov 18.

Department of Food Science, College of Agriculture, Purdue University, West Lafayette, IN 47907, United States. Electronic address:

Gluten proteins and their impact in the quality of wheat based food products is well known. In order visualize the 'in situ' distribution of low molecular weight glutenins, high molecular weight glutenins, and gliadins simultaneously in wheat doughs we needed to overcome and eliminate dough auto-fluorescence, and to develop a reliable immunostaining procedure for their simultaneous detection in wheat doughs. We are studying different auto-fluorescence quenchers used in biological fluorescent imaging and their effect on dough auto-fluorescence removal, and the effect of different fixative mediums on the adhesion of wheat flours doughs onto microscope slides. Read More

Enzyme Microb Technol 2019 Jul 4;126:18-23. Epub 2019 Mar 4.

Department of Biological Engineering, Inha University, Incheon, 22212, Republic of Korea. Electronic address:

A solvent-mediated method (SMM) was used to prepare supersaturated sugar solutions in hydrophobic and mixture of hydrophilic/hydrophobic ionic liquids (ILs), namely, [Bmim][TfN] and [Bmim][TfO]/[Bmim][TfN], respectively. In this method, sugars were first solubilized in a mixture of organic solvent and water (i.e. Read More

Food Chem 2019 Aug 25;290:32-39. Epub 2019 Mar 25.

National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China. Electronic address:

The flavor fingerprint of Tricholoma matsutake Singer was developed and volatile compounds were investigated by HS-GC-IMS fingerprinting combining with PCA. A total of 25 typical target compounds were identified. The differences of flavor compounds in pileus and stipe of Tricholoma matsutake Singer from different areas were observed. Read More

J Microbiol Methods 2019 Apr 15. Epub 2019 Apr 15.

Escola Superior de Agricultura "Luiz de Queiroz" (ESALQ), Universidade de São Paulo, P.O. Box 9, 13418-900 Piracicaba, SP, Brazil.

A simple generic toxicity method (test) is proposed using baker's yeast to mediate the reduction of the colourless triphenyltetrazolium chloride (TTC) to red, 1,3,5-triphenyl formazan, which can be extracted by dimethyl sulfoxide (DMSO), enabling the identification of reducible toxic compounds (e.g. cadmium, fipronil) in water for consumption. Read More

J Nat Prod 2019 Apr 18. Epub 2019 Apr 18.

National Research Council (CNR) , Institute of Neuroscience , 09042 Monserrato , Italy.

Nine compounds, including two undescribed withanolides, withasomniferolides A and B (1 and 2), three known withanolides (3-5), a ferulic acid dimeric ester (6), and an inseparable mixture of three long alkyl chain ferulic acid esters (7-9), were isolated from a GABA receptor positive activator methanol extract of the roots of Withania somnifera. The structures of the isolated compounds were elucidated based on NMR, MS, and ECD data analysis. In order to bioassay the single ferulic acid derivatives, compounds 6-9 were also synthesized. Read More

J Phys Chem A 2019 Apr 18. Epub 2019 Apr 18.

The best currently available set of temperature-dependent non-rigid rotor anharmonic oscillator (NRRAO) thermochemical and thermophysical properties of hydroxymethyl radical is presented. The underlying partition function relies on a critically evaluated complement of accurate experimental and theoretical data, and is constructed using a two-pronged strategy that combines contributions from large amplitude motions obtained from direct counts, with contributions from the other internal modes of motion obtained from analytic NRRAO expressions. The contributions from the two strongly coupled large-amplitude motions of CHOH, OH torsion and CH wag, are based on energy levels obtained by solving the appropriate two-dimensional projection of a fully-dimensional potential energy surface that was recently obtained at the CCSD(T)/cc-pVTZ level of theory. Read More

J Vector Borne Dis 2018 Oct-Dec;55(4):282-290

World Health Organization, SEARO, New Delhi, India.

Background & Objectives: Vector control strategies play significant role in reducing the transmission of malaria, dengue and other vector-borne diseases. The control of vector population using synthetic insecticides has resulted in development of insecticide resistance and negative effects on humans and environment. The present investigation evaluated the larvicidal potential of methanol, dichloromethane and hexane extracts of leaves and seeds of Ricinus communis (castor) plant against the early IV instar larvae of the dengue vector, Aedes aegypti, and malaria vector, Anopheles culicifacies. Read More

Chem Sci 2019 Mar 23;10(9):2578-2584. Epub 2019 Jan 23.

School of Chemical Engineering & Technology , Tianjin University , Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300072 , China . Email: ; Email:

Catalytic reforming provides a practical technique for on-board hydrogen production in fuel cell applications. The high energy density, easy transportation and non-toxicity of biomass-derived dimethyl ether (bio-DME) offer potential to replace methanol for on-board steam reforming (SR). Presently, the reaction mechanism over conventional Cu-based SR catalysts remains elusive, limiting the rational design of highly efficient reforming systems. Read More

Chem Sci 2019 Mar 4;10(11):3360-3365. Epub 2019 Feb 4.

Department of Chemistry , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen , 361005 , PR China . Email: ; Email:

We report the synthesis and structures of two 34-atom metal nanoclusters, namely [Ag(BTCA)(C[triple bond, length as m-dash]CBu )(tfa)(CHOH)]SbF and [AuAg(BTCA)(C[triple bond, length as m-dash]CBu )(tfa)(CHOH)]SbF, where HBTCA is -butylthiacalix[4]arene and tfa is trifluoroacetate. Their compositions and structures have been determined by single-crystal X-ray structural analysis and ESI-MS. The cationic cluster consists of a centered icosahedron M@Ag (M = Ag or Au) core that is surrounded by 21 peripheral silver atoms. Read More

Chem Sci 2019 Mar 6;10(11):3289-3294. Epub 2019 Feb 6.

Division of Chemistry , Graduate School of Science , Kyoto University , Kitashirakawa-Oiwakecho, Sakyo-ku , Kyoto , 606-8502 , Japan . Email: ; Email:

We report the synthesis and characterization of highly active Cu nanoparticles covered with zirconium/hafnium-based metal-organic frameworks for CO hydrogenation to methanol. Compared to , , and composites, UiO-66 acts as the most active support, with producing methanol at a rate 70 times higher than that of . In addition, the replacement of Zr with Hf in UiO-66 tripled in the rate of methanol production. Read More

Chem Sci 2019 Mar 11;10(11):3161-3167. Epub 2019 Feb 11.

Key Laboratory for Green Chemical Technology of Ministry of Education , School of Chemical Engineering and Technology , Tianjin University , Collaborative Innovation Center of Chemical Science and Engineering , Tianjin 300072 , China . Email:

Oxide-supported Rh nanoparticles have been widely used for CO hydrogenation, especially for ethanol synthesis. However, this reaction operates under high pressure, up to 8 MPa, and suffers from low CO conversion and alcohol selectivity. This paper describes the crucial role of hydroxyl groups bound on Rh-based catalysts supported on TiO nanorods (NRs). Read More

J Food Sci Technol 2019 Apr 21;56(4):2278-2286. Epub 2019 Mar 21.

Department of Food Technology, Guru Jambheshwar University of Science and Technology, Hisar, 125001 India.

Methanolic, ethanolic and ethyl acetate extracts of five aonla varieties were analyzed for phytochemical characterization using RP-HPLC. Five compounds viz. ascorbic acid, gallic acid, ellagic acid, ethyl gallate and quercetin were identified in aonla extracts by RP-HPLC at 270 nm. Read More

J Food Sci Technol 2019 Apr 28;56(4):2010-2015. Epub 2019 Feb 28.

Department of Food Technology, Guru Jambheshwar University of Science and Technology, Hisar, 125001 India.

The present study was undertaken to evaluate physico-chemical composition and to study the effect of processing on phytochemical contents and nutritional components of anola juice prepared from Banarasi cultivar. Aonla juice pasteurized at 90 °C for 1 min showed better retention of phytochemicals as well as sensory characteristics. Methanol was used as a solvent for extraction of phytochemicals and reversed phase high performance liquid chromatography was performed to identify and quantify the phytochemical contents in juice extract. Read More

Biosci Trends 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University.

Streptococcus pyogenes causes several infectious diseases such as tonsillitis, cellulitis, and streptococcal toxic shock syndrome. As antibiotics are used for the general treatment of S. pyogenes infection, cases of treatment failure due to drug-resistant bacteria have increased. Read More

Drug Dev Ind Pharm 2019 Apr 17:1-27. Epub 2019 Apr 17.

b Department of Pharmaceutics , College of Pharmacy, King Saud University , P.O. Box: 2457 , Riyadh 11451 , Saudi Arabia.

Gemfibrozil (GEM) is cholesterol-lowering agent which is being proposed as poorly water soluble drug (PWSD). Temperature based solubility values of GEM are not yet available in literature or any pharmacopoeia/monograph. Hence, the present studies were carried out to determine the solubility of PWSD GEM (as mole fraction) in various pharmaceutically used solvents such as "water (HO), methanol (MeOH), ethanol (EtOH), isopropanol (IPA), 1-butanol (1-BuOH), 2-butanol (2-BuOH), ethylene glycol (EG), propylene glycol (PG), polyethylene glycol-400 (PEG-400), ethyl acetate (EA), dimethyl sulfoxide (DMSO) and Transcutol® (THP)" at the temperatures ranging from "T = 298. Read More

Inorg Chem 2019 Apr 17. Epub 2019 Apr 17.

Department of Applied Chemistry, School of Engineering , The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku, Tokyo 113-8656 , Japan.

A ring-shaped polyoxometalate (POM), [PWO] (P8W48), formed by condensation of four hexavacant lacunary α-Dawson-type [α-PWO] units, is an attractive superlacunary compound possessing a large cavity (approximately 10 Å). Although the introduction of metal species into the cavity was attempted in aqueous media using the K/Li salt of P8W48, we encountered several challenges: excess metal species are required, and K and/or Li remain in the cavity. Therefore, controlling the number and arrangement of the introduced metal species proved difficult. Read More

J Chem Theory Comput 2019 Apr 17. Epub 2019 Apr 17.

The application of bottom-up coarse grained (CG) models to study the equilibrium mixing behavior of liquids is rather challenging, since these models can be significantly influenced by the density or the concentration of the state chosen during parametrization. This dependency leads to low transferability in density/concentration space and has been one of the major limitations in bottom-up coarse graining. Recent approaches proposed to tackle this shortcoming range from the addition of thermodynamic constraints, to an extended ensemble parametrization, to the addition of supplementary terms to the system's Hamiltonian. Read More

J Chromatogr Sci 2019 Apr 17. Epub 2019 Apr 17.

Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt.

Two sensitive chromatographic methods have been developed, and validated for chlorpheniramine maleate (CM), phenylephrine (PE) and guaifenesin (GF) determination in their mixture and in presence of GF related substance guaiacol (GL) and preservative namely; sodium benzoate (NaB). The first method was based on thin layer chromatographic separation (TLC) followed by densitometric determination of the separated spots. The separation was achieved using silica gel 60 F254 TLC plates and ethyl acetate: methanol: toluene: ammonia (7:1. Read More

Phys Chem Chem Phys 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA.

The introduction of metal alkoxides has been proposed as an attractive option to enhance hydrogen binding energies in porous materials such as metal-organic frameworks (MOFs) for room-temperature hydrogen storage applications. The presence of residual solvent molecules from MOF synthesis can, however, affect the performance of these functional groups. We perform quantum chemical calculations to predict solvent binding energies onto the metal-alkoxides and the temperatures required to drive off the solvent molecules and successfully activate porous materials with these moieties. Read More

Org Lett 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering , Kansai University , Suita , Osaka 564-8680 , Japan.

IrCl(cod)]/dppe-catalyzed α-methylation of aryl esters using methanol as the C1 source was developed. This methylation process is useful in several fields including organic chemistry, biochemistry, and medicinal chemistry. Readily available methanol as methylation reagent was successfully adapted. Read More

Electrophoresis 2019 Apr 16. Epub 2019 Apr 16.

School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.

In the presence of methanol and n-decanol as porogens, a partially filled capillary monolithic column was prepared by in situ reaction of glycidyl methacrylate and poly (ethylene glycol) diacrylate. Then, Pharmalyte 3-10 was immobilized on this column in order to obtain a capillary isoelectric focusing (cIEF) column with monolithic immobilized pH gradient (M-IPG). In addition, an online self-built platform for protein separation was established on account of the introduction of a cross-shaped unit and two short-off valves. Read More

J Sci Food Agric 2019 Apr 16. Epub 2019 Apr 16.

University of Belgrade, Faculty of Agriculture, Department of Food and Industrial Microbiology, Belgrade, Serbia.

Background: The ability of Coriolus versicolor medicinal mushroom to accumulate and transform selenium from selenourea and sodium selenite into an organic form L-selenomethionine during growth in liquid medium is examined in this paper. Additionally, the impact of supplementation on biological activity of the selenated mushroom methanol extracts, as well as their chemical composition is studied.

Results: Selenium accumulation was more efficient with sodium selenite application, but biomass yield was significantly lower (1. Read More

Chem Commun (Camb) 2019 Apr 17. Epub 2019 Apr 17.

Evonik Chair of Organic Chemistry, Faculty of Chemistry and Biochemistry, Ruhr Universität Bochum, ZEMOS 2.27, Universitätsstr. 150, 44801 Bochum, Germany.

A di-iodo-bridged PdI dimer bearing an N-heterocyclic carbene ligand was made accessible via the reduction of [(IPr)PdI2]2 in basic methanol solution. The structural features of [(IPr)PdI]2 were explored by single-crystal X-ray analysis. It was found to be a convenient one-component precatalyst with high activity in Suzuki-Miyaura, Buchwald-Hartwig, and Sonogashira reactions. Read More

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1505-1512

a Department of Pharmacy , the Affiliated Hospital of Qingdao University , Qingdao , P.R. China.

1G, a novel derivative of curcumin, exhibits promising anticancer activities in various cancer cell lines. To support its further pharmacological studies, a liquid chromatography-tandem mass spectrometry method was developed and validated in accordance with FDA's Guidance. After extraction by protein precipitation, analytes were separated by a 4. Read More

Sci Total Environ 2019 Apr 4;673:470-479. Epub 2019 Apr 4.

Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials (LSRE-LCM), Departamento de Engenharia Química, Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal. Electronic address:

In the current study, a treatment train strategy for urban mature leachates, comprising biological and physicochemical processes, was tested for full legal compliance. The leachate presents a high organic and nitrogen content (1.1 g C/L; 3. Read More

Eur J Med Chem 2019 Apr 9;173:99-106. Epub 2019 Apr 9.

Department of Chemistry, Bar-Ilan University, Ramat-Gan, 52900, Israel. Electronic address:

Diagnosis and treatment of breast cancer can be greatly enhanced and personalized based on the quantitative detection of mRNA markers. Here, we targeted the development of a fluorescent oligonucleotide probe to detect specifically the HER-2 mRNA breast cancer marker. We have selected the chromophore of the Green Fluorescent Protein (GFP), 4-hydroxybenzylidene imidazolinone (HBI), as a fluorophore covalently bound to an oligonucleotide probe and potentially capable of intercalating within a probe-mRNA duplex. Read More

Leg Med (Tokyo) 2019 Apr 10;38:58-63. Epub 2019 Apr 10.

Dipartimento di Chimica e Farmacia, Università di Sassari, 07100 Sassari, Italy.

The widespread diffusion of new psychoactive substances, requires a continuous update and development of new methods able to identify and quantify these new molecules in biological matrices. In this study an analytical method for the determination of two new benzodifuranyl derivatives, 1-(2,3,6,7-tetrahydrofuro[2,3-f][1]benzofuran-4-yl)propan-2-amine and 2-(2,3,6,7-tetrahydrofuro[2,3-f][1]benzofuran-4-yl)ethanamine, in rat plasma was developed. A solid phase extraction using C18 cartridges was carried out obtaining good recoveries with low matrix effect. Read More

J Inorg Biochem 2019 Mar 29;196:110680. Epub 2019 Mar 29.

Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, PR China. Electronic address:

Three new oxidovanadium(V) complexes were designed, synthesized and characterized by C, H, N elemental analysis, single crystal X-ray diffraction，UV/Vis and IR spectra. Complex 1: [VOLX] (HL = (E)-N'-(2-hydroxybenzylidene)-3-methbenzohydrazide, HX = ethylmaltol = 2-ethyl-3-hydroxy-4-pyrone), Complex 2: [VOL(CHO)(CHOH)], (HL = CHNO = (E)-N'-(2-hydroxybenzylidene)-3,5-dimethoxybenzohydrazide, CHOH = methanol), Complex 3: [VOLX] (HL = (E)-N'-(3-ethoxy-2-hydroxybenzylidene)-3,5-dimethoxybenzohydrazide). The insulin-like activity of the three complexes was tested. Read More

Biomed Chromatogr 2019 Apr 16:e4556. Epub 2019 Apr 16.

Clinical Pharmacokinetics Laboratory, China Pharmaceutical University, Nanjing, Jiangsu Province, China.

GL-V9, a derivative of wogonin, shows much more potent anticancer properties than wogonin. In this study, a selective, sensitive and rapid ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the determination of GL-V9 in rat plasma. Plasma samples were processed using methanol to precipitate protein. Read More

J Phys Chem B 2019 Apr 15. Epub 2019 Apr 15.

We test the OPLS/AA force field for a single PNIPAM 40-mer in aqueous solution using replica exchange molecular dynamics simulations and find that the force field fails to reproduce the experimental temperature behavior. To resolve this issue, we apply a modification on the partial charges previously suggested to reproduce the liquid-liquid phase separation of NIPAM aqueous solutions. The modified force field features stronger amide-water electrostatic interactions than the original OPLS model, predicts a weaker water-mediated monomer-monomer attraction, and reproduces the experimental coil-globule collapse enthalpy of PNIPAM in water. Read More

Plant Signal Behav 2019 Apr 16:1-7. Epub 2019 Apr 16.

a Central Department of Botany , Tribhuvan University , Kathmandu , Nepal.

Cymbidium aloifolium is known for its ornamental and medicinal values. It has been listed as threatened orchid species. In this study, in vitro propagated C. Read More

Inorg Chem 2019 Apr 16. Epub 2019 Apr 16.

CNRS, LCC (Laboratoire de Chimie de Coordination) , Université de Toulouse , UPS, INPT, 205 Route de Narbonne, BP 44099 , F-31077 , Toulouse Cedex 4 , France.

Cyanoisopropyl radicals, generated thermally by the decomposition of azobis(isobutyronitrile) (AIBN), participate in reductive radical termination (RRT) under the combined effect of copper(I) complexes and proton donors (water, methanol, triethylammonium salts) in acetonitrile or benzene. The investigated copper complexes were formed in situ from [Cu(MeCN)]BF in CDCN or CuBr in CD using tris[2-(dimethylamino)ethyl]amine (MeTREN), tris(2-pyridylmethyl)amine (TPMA), and 2,2'-bipyridine (BIPY) ligands. Upon keeping all other conditions constants, the impact of RRT is much greater for the MeTREN and TPMA systems than for the BIPY system. Read More

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):298-307

Jiangsu Kanion Pharmaceutical Co.,Ltd. Lianyungang 222001,China State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process Lianyungang 222001,China.

The study aims to qualitatively analyze the chemical composition of compound Nanxing acesodyne plaster by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry( UPLC-Q-TOF-MS/MS). The analysis was performed on Agilent Zorbax SB-C_(18)( 4. 6 mm×250 mm,5 μm) column. Read More

J Vet Res 2019 Mar 22;63(1):87-91. Epub 2019 Mar 22.

Department of Pharmacology and Toxicology, National Veterinary Research Institute, 24-100 Puławy, Poland.

Introduction: Quercetin is a polyphenolic flavonoid which has been used in traditional Chinese medicine as a natural therapeutic agent with a broad spectrum of activities (antioxidant, anticancer, neuroprotective, anti-inflammatory, antiviral and antibacterial). The aim of this study was to develop and validate a rapid and simple ultra-high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) method for the determination of quercetin in milk.

Material And Methods: Sample preparation was based on a liquid-liquid extraction with 0. Read More

Biotechnol Rep (Amst) 2019 Sep 20;23:e00325. Epub 2019 Mar 20.

TERI-Deakin Nanobiotechnology Centre, TERI Gram, The Energy and Resources Institute (TERI), Gwal Pahari, Gurugram, Haryana, 122002, India.

Mycorrhizal hairy roots of produce high amount of rosmarinic acid and are also valuable resource of quality mycorrhizal spores. To utilize their potential as continuous resource of biological and biochemical products, an efficient separation method is required. Solvent based extraction methods have a negative impact on mycorrhizal spore viability and vitality. Read More

J Chromatogr A 2019 Apr 8. Epub 2019 Apr 8.

Department of Chemistry, Tarbiat Modares University, Tehran, Iran.

In the present study, an electrospun composite of polyamide-graphene oxide-polypyrrole was synthesized. The characterization of the synthesized material was accomplished using field emission scanning electron microscopy (FESEM) and Fourier transform infrared spectroscopy (FT-IR). FESEM images showed uniform and beadles nanofibers. Read More

J Food Drug Anal 2019 Apr 31;27(2):510-517. Epub 2018 Dec 31.

Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

Vitamin D has been considered to regulate calcium and phosphorus homeostasis and to preserve skeletal integrity. Serum 25-hydroxyvitamin D (25(OH)D) is the best indicator of vitamin D levels. The association of serum 25(OH)D deficiency with increased risk of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) is controversial. Read More

Mar Drugs 2019 Apr 4;17(4). Epub 2019 Apr 4.

Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, China.

Phlorotannins are polyphenolic metabolites of marine brown algae that have been shown to possess health-beneficial biological activities. An efficient approach using a combination of high-speed counter-current chromatography (HSCCC) and size exclusion chromatography with a Sephadex LH-20 has been successfully developed for the isolation and purification of a neuroprotective phlorotannin, eckmaxol, from leaves of the marine brown algae, . The phlorotannin of interest, eckmaxol, was isolated with purity >95% by HSCCC using an optimized solvent system composed of -hexane-ethyl acetate-methanol-water (2:8:3:7, v/v/v/v) after Sephadex LH-20 size exclusion chromatography. Read More