Search Our Scientific Publications & Authors

J Med Chem 2019 Feb 20. Epub 2019 Feb 20.

Recently, our research group reported the identification of BMS-986104 (2) as a differentiated S1P1 receptor modulator. In comparison to fingolimod (FTY720, 1), a full agonist of S1P1 currently marketed for the treatment of relapse remitting multiple sclerosis (RRMS), 2 offers several potential advantages having demonstrated improved safety multiples in pre-clinical evaluations against undesired pulmonary and cardiovascular effects. In clinical trials, 2 was found to exhibit a pharmacokinetic half-life (T1/2) longer than that of 1, as well as a reduced formation of the phosphate metabolite that is required for activity against S1P1. Read More

Mol Omics 2019 Feb 20. Epub 2019 Feb 20.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, P. R. China.

A formaldehyde-degrading strain Methylobacterium sp. XJLW was isolated and exhibited a special phenotype for formaldehyde utilization. The accumulation of formic acid in large quantities and lower cell growth was detected when XJLW utilized formaldehyde as the sole carbon source, suggesting XJLW has a potentially novel pathway to transfer formaldehyde to methanol and then enter the serine cycle for C1 metabolism. Read More

J Pharm Biomed Anal 2019 Feb 6;168:44-54. Epub 2019 Feb 6.

School of Medicine, Tongji University, No. 1239 Siping Road, Shanghai 200092, PR China; Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai 200433, PR China; Shanghai Key Laboratory for Pharmaceutical Metabolite Research, School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai 200433, PR China; Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University, No. 100 Haining Road, Shanghai 200025, PR China. Electronic address:

Tuberculosis is one of the top concerns in the world and acutely threatens human health. A new potent candidate regimen containing pyrazinamide (PZA), ethambutol (EMB), protionamide (PTO) and clofazimine (CFZ) was proposed by Parabolic Response Surface/Feedback System Control (FSC/PRS) system and showed excellent outcomes in vitro and vivo studies. Here, a convenient liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneously determination of four compounds in beagle dog plasma. Read More

J Environ Sci (China) 2019 May 13;79:153-160. Epub 2018 Dec 13.

Shenzhen Key Laboratory of Industrial Water Conservation and Municipal Wastewater Reclamation Technology, Shenzhen Polytechnic, Guangdong 518055, China.

Various methods for shifting the optical response of TiO into the visible (Vis) range have been reported. Herein, we reported the application of a TiO/HO/Vis process and the effects of TiO crystalline structure on the degradation of terbuthylazine. The results indicated that TiO crystalline structure and HO addition had significant effects on terbuthylazine degradation: its degradation rate could be increased from 7% to 70% with HO addition after 180 min of reaction, the synergistic degradation of terbuthylazine by TiO-Fe was substantially accelerated, with the degradation rate reaching up to 100% after 20 min of reaction, and rutile TiO showed better photocatalytic activity and a more obvious synergistic effect than anatase TiO. Read More

Anal Bioanal Chem 2019 Feb 19. Epub 2019 Feb 19.

Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, 94720, USA.

Metabolism of chemicals from the diet, exposures to xenobiotics, the microbiome, and lifestyle factors (e.g., smoking, alcohol intake) produce electrophiles that react with nucleophilic sites in circulating proteins, notably Cys34 of human serum albumin (HSA). Read More

Nanoscale 2019 Feb 20. Epub 2019 Feb 20.

Materials Science Division, Argonne National Laboratory, Argonne, Illinois 60439, USA. and Institute for Molecular Engineering, The University of Chicago, Chicago 60637, USA.

Cu nanoassemblies formed transiently during reaction from size-selected subnanometer Cu4 clusters supported on amorphous OH-terminated alumina convert CO2 into methanol and hydrocarbons under near-atmospheric pressure at rates considerably higher than those of individually standing Cu4 clusters. An in situ characterization reveals that the clusters self-assemble into 2D nanoassemblies at higher temperatures which then disintegrate upon cooling down to room temperature. DFT calculations postulate a formation mechanism of these nanoassemblies by hydrogen-bond bridges between the clusters and H2O molecules, which keep the building blocks together while preventing their coalescence. Read More

Pharmazie 2019 Jan;74(1):18-22

The electrochemical behavior of the echinocandin antifungals anidulafungin (AF) and micafungin (MF) has been investigated by differential pulse polarography (DPP). The measurements were carried out in a supporting electrolyte solution consisting of Britton-Robinson buffer and methanol at various substance concentrations and pH values. An amperometric cell with a three electrode system consisting of a dropping mercury electrode (DME) as working electrode, an auxiliary platinum electrode and an Ag/AgCl reference electrode was used in all experiments. Read More

Plant Dis 2006 May;90(5):686

USDA-ARS, Stillwater, OK.

Wheat (Triticum aestivum L.) is an important crop in Oklahoma and throughout the Central Plains of the United States. The soilborne fungus, Sclerotium rolfsii, is a major pathogen on peanut (Arachis hypogaea L. Read More

Plant Dis 2007 Dec;91(12):1621-1624

Department of Plant Pathology, National Chung Hsing University, Taichung, Taiwan.

Among 65 species of oriental medicinal plants tested, 39 contained substances inhibitory to conidial germination of Alternaria brassicicola, with the most inhibitory extract from speedweed (Polygonum perfoliatum). The inhibitory substances in dried speedweed were insoluble in water. However, the inhibitors were readily extracted with ethanol or methanol, but not with acetone, ether, or chloroform. Read More

Metabolites 2019 Feb 13;9(2). Epub 2019 Feb 13.

Hollings Marine Laboratory, Chemical Science Division, National Institute of Standards and Technology, Charleston, SC 29412, USA.

The field of metabolomics generally lacks standardized methods for the preparation of samples prior to analysis. This is especially true for metabolomics of reef-building corals, where the handful of studies that were published employ a range of sample preparation protocols. The utilization of metabolomics may prove essential in understanding coral biology in the face of increasing environmental threats, and an optimized method for preparing coral samples for metabolomics analysis would aid this cause. Read More

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

College of Life Science, Sichuan Agricultural University, Ya'an 625014, China.

The aim of this study was to evaluate the antioxidant activities of extracts from olive leaves (EOL). The main contents of EOL were determined by colorimetric methods. The antioxidant activities were assessed by measuring the scavenging free radicals in vitro. Read More

J Steroid Biochem Mol Biol 2019 Feb 16. Epub 2019 Feb 16.

Department of Chemistry, University of Oslo, Norway. Electronic address:

Oxysterols can contribute to proliferation of breast cancer through activation of the Estrogen Receptors, and to metastasis through activation of the Liver X Receptors. Endogenous levels of both esterified and free sidechain-hydroxylated oxysterols were examined in breast cancer tumours from Estrogen Receptor positive and negative breast tumours, using a novel fast liquid chromatography tandem mass spectrometry method. Multiple aliquots of five milligram samples of 22 tumours were analysed for oxysterol content to assess intra- and inter-tumour variation. Read More

Dalton Trans 2019 Feb 19. Epub 2019 Feb 19.

Facultad de Química de San Sebastián, Universidad del País Vasco (UPV/EHU), Apdo. 1072, 20080 San Sebastián, Spain.

The reaction of [RhCl(COD)]2 (COD = 1,5-cyclooctadiene) with racemic PPh2(CH(Ph)CH2CHO) and pyridine (py) led to the oxidative addition of the aldehyde, and a single geometric isomer of [RhHCl(PPh2(CH(Ph)CH2CO))(py)2] (1), with hydride trans to chloride, was obtained as a mixture of two diastereomers in a 95 : 5 ratio; this was in agreement with density functional theory (DFT) calculations. In a chloroform solution, the exchange of hydride by chloride yielded [RhCl2(PPh2(CH(Ph)CH2CO))(py)2] (2) as a mixture of a kinetically preferred species, trans-py-2a, and two diastereomers, cis-Cl-2b' and cis-Cl-2b, with cis pyridines and a chloride trans to acyl; as predicted by the DFT calculations, the latter was the major species. Complex 1 reacted with racemic PPh2(CH(Ph)CH2CHO) or PPh2(o-C6H4CHO) to afford [RhHCl(PPh2(CH(Ph)CH2CO))(κ1-PPh2(CH(Ph)CH2CHO))(py)] (3) or [RhHCl(PPh2(o-C6H4CO))(κ1-PPh2(CH(Ph)CH2CHO))(py)] (4), respectively, both with a dangling alkylaldehyde. Read More

Biosci Rep 2019 Feb 18. Epub 2019 Feb 18.

national research institute, cairo, 20, Egypt.

The extensive use of fipronil (FPN) may trigger hazards to more than insects. The present investigation was carried out to evaluate the abrogating role of methanol extract against the neurotoxic effects provoked by FPN. Fourty male albino rats rats were assigned into four equal groups. Read More

Biophys J 2019 Jan 29. Epub 2019 Jan 29.

Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario, Canada. Electronic address:

Methanol is a common solubilizing agent used to study transmembrane proteins/peptides in biological and synthetic membranes. Using small angle neutron scattering and a strategic contrast-matching scheme, we show that methanol has a major impact on lipid dynamics. Under increasing methanol concentrations, isotopically distinct 1,2-dimyristoyl-sn-glycero-3-phosphocholine large unilamellar vesicle populations exhibit increased mixing. Read More

J Colloid Interface Sci 2019 Jan 25;543:34-42. Epub 2019 Jan 25.

Department of Materials Science and Engineering, Iowa State University of Science and Technology, Ames, IA 50011, USA; Division of Materials Science & Engineering, Ames National Laboratory, Ames, IA 50011, USA. Electronic address:

Emulsion polymerization is a versatile approach to produce different polymeric nanoparticle morphologies, which can be useful in a variety of applications. However, the detailed mechanism of the morphology formation is not entirely clear. We study the kinetics of nanoparticle morphology evolution during a seeded emulsion polymerization using both experimental and computational tools. Read More

Langmuir 2019 Feb 18. Epub 2019 Feb 18.

Platinum-decorated graphene aerogel microspheres were fabricated through a combined electrospraying, freeze-casting and solvothermal process. Platinum nanoparticles with a narrow size distribution are evenly anchored on the graphene aerogel microspheres without agglomeration benefitting from the distinct center-diverging microchannel structure of the graphene aerogel microspheres, which results in the as-prepared catalysts presenting excellent electrocatalytic performance including high electrocatalytic activity and high poison tolerance towards methanol electrooxidation, showing great potential for direct methanol fuel cell anode catalysts. In particular, the Platinum-decorated graphene aerogel microspheres exhibits an extremely high mass activity of 1098. Read More

Chemphyschem 2019 Feb 18. Epub 2019 Feb 18.

UNSW Australia, School of Chemistry, High St, Kensington, 2052, Sydney, AUSTRALIA.

A general procedure for measurement of time-resolved diffusion coefficients of molecular species by NMR is described, including the use of methanol for fast temperature-independent gradient calibration. Read More

Eur J Mass Spectrom (Chichester) 2019 Feb;25(1):58-72

1 Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA, USA.

Electrospray ionization was used to generate species such as [ZnNO(CHOH)] from Zn(NO)•XHO dissolved in a mixture of CHOH and HO. Collision-induced dissociation of [ZnNO(CHOH)] causes elimination of CHOH to form [ZnNO(CHOH)]. Subsequent collision-induced dissociation of [ZnNO(CHOH)] causes elimination of 47 mass units (u), consistent with ejection of HNO. Read More

Biomed Chromatogr 2019 Feb 17:e4510. Epub 2019 Feb 17.

Key Laboratory of Drug Quality Control and Pharmacovigilance, (China Pharmaceutical University), Ministry of Education, Nanjing, China.

A sensitive liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of ramelteon and its active metabolite M-II in human plasma. After extracted from 200 μL of plasma by protein precipitation, the analytes and internal standard (IS) diazepam were separated on a Hedera ODS-2 (5 μm, 150 mm × 2.1 mm) column with a mobile phase consisted of methanol-0. Read More

Microbes Environ 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Fisheries Sciences, Hokkaido University.

The responses of bacterial communities to halocarbon were examined using a 28-d incubation of bromoform- and methanol-enriched subarctic surface seawater. Significant increases were observed in dibromomethane concentrations and bacterial 16S rRNA gene copy numbers in the treated substrates incubated for 13 d. The accumulated bacterial community was investigated by denaturing gradient gel electrophoresis and amplicon analyses. Read More

Ultrason Sonochem 2019 Feb 5. Epub 2019 Feb 5.

Chemical Engineering Faculty, Sahand University of Technology, P.O. Box 51335-1996, Sahand New Town, Tabriz, Iran; Reactor and Catalysis Research Center (RCRC), Sahand University of Technology, P.O. Box 51335-1996, Sahand New Town, Tabriz, Iran. Electronic address:

MCM-41 is a mesoporous silicate with hydrophobic structure which is a good candidate as catalyst support in biodiesel production, with high specific area (more than 1100 m/g) and high thermal stability. In this study the hydrothermal stability and acidic property of Al-MCM-41 were improved by addition of Ce element into its structure with various amounts of Si/Ce molar ratio. Then it was loaded by magnesium with two different procedures: customary impregnation and Sono-dispersion. Read More

Pak J Pharm Sci 2019 Jan;32(1):177-184

Department of Agronomy, The University of Agriculture, Peshawar, KPK, Pakistan.

Different solvent extracted samples from the leaves and fruits tissues of D. stramonium were tested against five pathogenic microorganisms by disc diffusion susceptibility method using 1, 2 and 3mg disc concentrations. Methanol and chloroform extracted fractions from both leaves and fruits measured good growth inhibition of all the tested microorganisms at all concentrations. Read More

Pak J Pharm Sci 2019 Jan;32(1):137-142

Department of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan.

Antiviral activity of Astragalus membranaceus aqueous and methanol root extracts was determined against Avian influenza H9 virus. Toxicity profile of extracts was evaluated using chicken embryos and BHK-21 cell line. Different concentrations (400, 200, 100, 50, 25. Read More

Pak J Pharm Sci 2019 Jan;32(1):109-115

Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia / Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Egypt.

The quorum sensing inhibitory (QSI) and antimicrobial potentials of the total methanol extract (TME) and different extractives as well as the sesquiterpenes: dehydrodihydrocostus lactone (1), dehydrocostus lactone (2), arbusculin A (3), santamarine (4), reynosin (5), and specioic acid (6) isolated from Costus speciosus rhizomes were evaluated. The CHCl3:EtOAc (1:1), EtOAc, and TME fractions exhibited potent antibacterial activity toward B. cereus with inhibition zone diameter 13 mm. Read More

Talanta 2019 May 24;197:530-538. Epub 2019 Jan 24.

Trace Element, Spectroscopy and Speciation Group (GETEE), Strategic Grouping in Materials (AEMAT), Department of Analytical Chemistry, Nutrition and Bromatology, Faculty of Chemistry, Universidade de Santiago de Compostela, Avenida das Ciencias, s/n., 15782 Santiago de Compostela, Spain. Electronic address:

Advances on nanometrology require reliable sample pre-treatment methods for extracting/isolating nanomaterials from complex samples. The current development deals with a discontinuous ultrasonication (60% amplitude, 15 cycles of ultrasound treatment for 59 s plus relaxing stage for 59 s, 20 mL of methanol) method for a fast and quantitative extraction of silver nanoparticles (Ag NPs) from moisturizing creams. Possibilities offered by modern inductively coupled plasma mass spectrometry (ICP-MS) which allow 'single particle' assessment (sp-ICP-MS) have been used for Ag NPs assessment (Ag NPs concentration and Ag size distribution). Read More

J Environ Manage 2019 Feb 13;236:534-550. Epub 2019 Feb 13.

Escola de Química, Federal University of Rio de Janeiro, Av. Horacio Macedo, 2030, Bl. E, 21949-900, Rio de Janeiro, RJ, Brazil. Electronic address:

Offshore oil/gas productions are power intensive and CO emitters from gas-fired power generation. This work investigates supersonic separator as a strategy for affording post-combustion capture backed up by cost reductions. Conventional offshore gas processing usually loses thermodynamic hydrate inhibitor methanol in processing and exported gas. Read More

Mikrochim Acta 2019 Feb 15;186(3):187. Epub 2019 Feb 15.

School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 401331, People's Republic of China.

A magnetite@graphene oxide nanocomposite was first coated with polyethylenimine and then modified with phytic acid and titanium(IV) ions. The high loading with Ti(IV) and the good hydrophilicity of PEI and PA result in a material that can be applied to the efficient extraction of highly polar nucleobases, nucleosides and nucleotides. The physicochemical properties of the composite were investigated by scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, water contact angle measurements, thermogravimetric analysis, and vibrating sample magnetometry. Read More

Nat Commun 2019 Feb 15;10(1):788. Epub 2019 Feb 15.

Hefei National Laboratory for Physical Sciences at the Microscale, Collaborative Innovation Center of Chemistry for Energy Materials, University of Science and Technology of China, Hefei, 230026, P.R. China.

The photofixation and utilization of CO via single-electron mechanism is considered to be a clean and green way to produce high-value-added commodity chemicals with long carbon chains. However, this topic has not been fully explored for the highly negative reduction potential in the formation of reactive carbonate radical. Herein, by taking BiO nanosheets as a model system, we illustrate that oxygen vacancies confined in atomic layers can lower the adsorption energy of CO on the reactive sites, and thus activate CO by single-electron transfer in mild conditions. Read More

Proc Natl Acad Sci U S A 2019 Feb 15. Epub 2019 Feb 15.

Applied Chemicals and Materials Division, National Institute of Standards and Technology, Boulder, CO 80305

This work investigates the link between residual entropy and viscosity based on wide-ranging, highly accurate experimental and simulation data. This link was originally postulated by Rosenfeld in 1977 [Rosenfeld Y (1977) 15:2545-2549], and it is shown that this scaling results in an approximately monovariate relationship between residual entropy and reduced viscosity for a wide range of molecular fluids [argon, methane, [Formula: see text], [Formula: see text], refrigerant R-134a (1,1,1,2-tetrafluoroethane), refrigerant R-125 (pentafluoroethane), methanol, and water] and a range of model potentials (hard sphere, inverse power, Lennard-Jones, and Weeks-Chandler-Andersen). While the proposed "universal" correlation of Rosenfeld is shown to be far from universal, when used with the appropriate density scaling for molecular fluids, the viscosity of nonassociating molecular fluids can be mapped onto the model potentials. Read More

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

Departamento de Química, Unidad Departamental de Química Analítica, Universidad de La Laguna (ULL), La Laguna, Tenerife 38206, Spain.

The pillared-layer Zn-triazolate metal-organic framework (CIM-81) was synthesized, characterized, and used for the first time as a sorbent in a dispersive micro-solid phase extraction method. The method involves the determination of a variety of personal care products in wastewaters, including four preservatives, four UV-filters, and one disinfectant, in combination with ultra-high performance liquid chromatography and UV detection. The CIM-81 MOF, constructed with an interesting mixed-ligand synthetic strategy, demonstrated a better extraction performance than other widely used MOFs in D-µSPE such as UiO-66, HKUST-1, and MIL-53(Al). Read More

Magn Reson Chem 2019 Feb 15. Epub 2019 Feb 15.

A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, Favorsky St. 1, 664033, Irkutsk, Russian Federation.

A systematic DFT study of the accuracy factors (functionals, basis sets, solvent effects) for the computation of N NMR chemical shifts has been performed in the series of condensed nitrogen containing heterocycles. The behavior of the most representative functionals was examined based on the benchmark calculations of N NMR chemical shifts in the reference set of compounds. It was found that the best agreement with experiment was achieved with OLYP functional in combination with aug-pcS-3(N)//pc-2 locally dense basis set scheme providing MAE of 5. Read More

Nanotechnology 2019 Feb 15. Epub 2019 Feb 15.

Institute of Polymer Product Engineering, Linz, AUSTRIA.

Novel sea cucumber-shaped polyaniline/ferric oxide (PANI/Fe2O3) nanocomposites were synthesized using a simple and efficient one-step hydrothermal process, and further assembling the nanocomposites onto a polyethylene terephthalate (PET) flexible substrate. Through monitoring the resistance of the PANI/Fe2O3 nanocomposites thick film and PANI/Fe2O3-PET flexible sensors, the responses of the sensors are obtained to various 100 ppm gases including methanol, triethylamine, aniline and other five gases. It is found that two kinds of sensors exhibit a high selectivity towards NH3. Read More

Water Res 2019 Feb 1;154:21-27. Epub 2019 Feb 1.

R&D Center, Samsung Engineering Co. Ltd, 41 Maeyoung-Ro, 269 Beon-Gil, Youngtong-Gu, Suwon, Gyeonggi-Do, 16523, South Korea. Electronic address:

The effect of dissolved oxygen (DO) on the degradation of methanol by ultraviolet (UV) light at 185 nm (UV-185) was examined in this study. The experiments were conducted using a bench-scale experimental apparatus that was operated under continuous conditions. In the control tests with various DO conditions, it was confirmed that UV irradiation of water without methanol produced approximately 54 μg/L of HO and removed 15%-90% of the DO. Read More

J Ethnopharmacol 2019 Feb 12;235:219-226. Epub 2019 Feb 12.

Pharmaceutical Analysis Laboratory, SIMS College of Pharmacy, Guntur, India. Electronic address:

Ethnopharmacological Relevance: The plant Tabebuia chrysantha (Jaq.) Nicholson (Bignoniaceae) is commonly known as "Golden Goddess" in the Southern part of India and "Golden Trumpet Tree " in Central America. Stems of this plant have been traditionally used for antioxidant, anti-inflammatory, antimicrobial and anticancer actions. Read More

J Ethnopharmacol 2019 Feb 12;235:279-292. Epub 2019 Feb 12.

Pharmacognosy and Phytochemistry Laboratory, VNS Group of Institutions, Faculty of Pharmacy, VNS Campus, Vidya Vihar, Neelbud, Bhopal, Madhya Pradesh 462044, India. Electronic address:

Ethno Pharmacological Relevance: Sida cordifolia is used commonly in traditional systems of medicine (TSM) and as folk remedies for treating the wounds (both external and internal), infected area, rheumatic disorders, muscular weakness, tuberculosis, heart problems, bronchitis, neurological problems etc. Therefore, in order to authenticate the claims, a mechanism-oriented investigation of the wound healing properties of this plant is essential.

Aim Of The Study: The overall aim of the present research is to understand the precise unknown cellular and molecular mechanism by which S. Read More

J Biotechnol 2019 Feb 12;294:30-37. Epub 2019 Feb 12.

Department of Chemical Engineering, Federal University of Santa Maria, 1000, Roraima Avenue, Santa Maria, RS, 97105-900, Brazil. Electronic address:

The aim of this work was the production of bioactive metabolites by submerged fermentation from the fungus Diaporthe schini, followed by their extraction, separation and characterization. Different solvents (methanol, dichloromethane and hexane) were used for the extraction of metabolites from the fermentation broth and the extracts obtained were evaluated by in vitro antibacterial and antifungal activity. The separation and characterization of the extract from the hexane extraction was performed by column chromatography and GC-MS, respectively. Read More

J Sep Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Veterinary Microbiology, University of Life Sciences, Lublin, Poland.

The great prevalence of thin-layer chromatography over HPLC is connected with the possibility of analyzing many samples in parallel. Therefore, the method is often used in screening and/or effect directed analysis to compare composition and chemical/biological properties of many samples in one run. It was already proved, that high performance thin-layer chromatography, in many cases, can replace HPLC for quantitative analysis. Read More

Inorg Chem 2019 Feb 15. Epub 2019 Feb 15.

Department of Chemistry and State Key Laboratory of Advanced Textiles Materials and Manufacture Technology, Ministry of Education , Zhejiang Sci-Tech University , Hangzhou 310018 , China.

Understanding the mechanisms of methane activation is an important and active research area of the contemporary catalyzed conversion of hydrocarbons to shippable, valuable feedstock and has invoked close collaborations between experimentalists and theorists. This article describes the trapping of reaction intermediates in a copper-catalyzed direct methane-to-methanol conversion. Specifically, two hydroxy(methoxy)copper(I) [CHOCu(OH)] isomeric intermediates were distinguished and characterized by matrix isolation infrared spectroscopy and O, CD, and CH isotopic substitution experiments combined with quantum chemical calculations. Read More

Org Biomol Chem 2019 Feb 15. Epub 2019 Feb 15.

The State Key Laboratory of Chemical Oncogenomics, the Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P. R. China. and School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, P. R. China.

Several donor-acceptor type conjugated polyelectrolytes containing naphthalimide are developed. Different polymer chain configurations of the backbones of polymers lead to different photophysical properties. The para-substituted polymers show extended conformations with quite low quantum yields in high polarity solvents because of twisted intramolecular charge transfer features, while the meta-substituted polymers can form helices and demonstrated significantly improved quantum yields in water and methanol, as well as achieving sensitive, ultrafast and ratiometric detection of trace methylene blue in water. Read More

J Biomol Struct Dyn 2019 Feb 15:1-13. Epub 2019 Feb 15.

a C. G. Bhakta Institute of Biotechnology , Uka Tarsadia University , Maliba Campus, Bardoli , Surat 394 350 , Gujarat , India.

This study explores the antimicrobial properties of bioactive secondary metabolites extracted from the medicinal plant (Solanum surattense) associated Bacillus subtilis strain SSL2. The secondary metabolites were extracted from B. subtilis (SSL2) using ethyle acetate, acetone, butanol, chloroform, and methanol solvents. Read More

Bioanalysis 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co., Inc., West Point, PA, USA.

Aim: MK-8591 (EFdA), a novel anti-HIV nucleoside analog, is converted to mono-, di- and tri-phosphates (MK-8591-MP, MK-8591-DP and MK-8591-TP) intracellularly, among which MK-8591-TP is the active pharmacological form. An ultrasensitive LC-MS/MS assay was required to measure MK-8591-DP and MK-8591-TP levels in human peripheral blood mononuclear cells (PBMCs). Sensitivity and reproducibility were major bottlenecks in these analyses. Read More

Adv Mater 2019 Feb 15:e1803390. Epub 2019 Feb 15.

School of Chemical Engineering, Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea.

Value-added aromatic monomers such as benzene, toluene, and xylenes (BTX) are very important building-block chemicals for the production of plastics, polymers, solvents, pesticides, dyes, and adhesives. Syngas-to-aromatics (STA) is a very promising approach for the synthesis of aromatic monomers, and is catalyzed via bifunctional catalysts in a single reactor, wherein methanol/dimethyl ether and/or olefins intermediates formed from syngas on metal components are converted into aromatic monomers exclusively on the HZSM-5 by cascade reactions. Since an optimal Fischer-Tropsch synthesis (FTS) temperature of Fe-based catalysts is very close to an aromatization temperature of HZSM-5, Fe-based catalysts have been frequently used/modified for the synthesis of aromatic monomers from hydrogenation of carbon oxides (CO and CO ). Read More

J Cell Biochem 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon.

The type 2 diabetes is one of the major global health issues that affects millions of people. This study evaluated the antidiabetic activity of aqueous extracts (AECP) and methanol extracts (MECP) from Ceiba pentandra trunk bark on an experimental model of type 2 diabetes (T2D). This model was induced in rats by the combination of a high-fat diet (HFD) and a single dose of streptozotocin (40 mg/kg, intraperitoneal) at the seventh day of experimentation. Read More

Nano Converg 2019 Feb 15;6(1). Epub 2019 Feb 15.

National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Shanghai Jiao Tong University, Shanghai, 200240, China.

Combustion is a chemical reaction that emits heat and light. Nanofire is a kind of flameless combustion that occurs on the micro-nano scale. Pt/AlO film with a thickness of 20 nm can be prepared as a catalyst by micro-nano processing. Read More

Nanoscale Res Lett 2019 Feb 14;14(1):57. Epub 2019 Feb 14.

School of Materials Science and Engineering, Yunnan Key Laboratory for Micro/Nano Materials and Technology, Yunnan University, Kunming, China.

In this work, we synthesized SmO/ZnO/SmFeO microspheres by a hydrothermal method combined with microwave assistance to serve as a methanol gas sensor. We investigated the effect on the microstructure at different hydrothermal times (12 h, 18 h, 24 h, and 30 h), and the BET and XPS results revealed that the specific surface area and adsorbed oxygen species were consistent with a microstructure that significantly influences the sensing performance. The gas properties of the SmO-doped ZnO/SmFeO microspheres were also investigated. Read More

Saudi Pharm J 2019 Feb 8;27(2):220-224. Epub 2018 Nov 8.

Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Previously, the antimicrobial activity of was traced to benzyl isothiocyanate. In the present study known inactive compounds were isolated from extracts obtained by different solvents including -amyrin, -sitosterol, stigmasterol glucoside, benzyl cyanide and sulphur. However, some inactive compounds were present only in the ethanol and methanol extracts. Read More

Ultrason Sonochem 2019 Jan 28. Epub 2019 Jan 28.

Department of Chemical Engineering, Institute of Chemical Technology, Matunga, Mumbai 400019, India. Electronic address:

The present study investigates the use of ultrasound in size reduction based on recrystallization of a commercially important compound, 3,3'-diaminodiphenyl sulfone, popularly known as DADPS. Typically the applications of DADPS depends on the size distribution, more importantly on the mean size and hence the ultrasound assisted recrystallization has been applied for controlling the size as an alternative to energy intensive mechanical size reduction. For the size reduction studies, DADPS was dissolved in methanol and irradiated with ultrasound during the anti-solvent crystallization operation using water. Read More

J Nanosci Nanotechnol 2019 Jul;19(7):4315-4322

Council of Scientific and Industrial Research-National Physical Laboratory, Dr. K.S. Krishnan Marg, New Delhi 110012, India.

The higher methanol utilization efficiency in direct methanol fuel cell (DMFC) is one of the key parameter to show the performance of an anode catalyst. Here in, we have synthesized a highly efficient and stable PtCo anode nanocatalysts (2-4 nm size) supported on reduced graphene oxide (rGO) for the electro-oxidation of methanol in a DMFC. Three different compositions of anode catalysts PtCo (1:7)/rGO, PtCo (1:9)/rGO and PtCo (1:11)/rGO comprising of 20% metal loading by weight of rGO are being investigated for methanol electro-oxidation in acidic medium with different methanol concentration using cyclic voltammetry. Read More