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    4623 results match your criteria Metastatic Neoplasms to the Oral Cavity

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    Mouth examination performance by children's parents and by adolescents in Fanconi anemia.
    Pediatr Blood Cancer 2017 May 13. Epub 2017 May 13.
    Department of Stomatology, Post Graduate Program in Dentistry, Federal University of Paraná School of Dentistry, Curitiba, Paraná, Brazil.
    Background: Fanconi anemia (FA) is a rare genetic syndrome characterized by increased risk of developing malignant neoplasms, particularly oral squamous cell carcinoma. This study aims to ascertain the extent to which adolescents and guardians/parents of children with FA are aware of their oral cancer risks and assess their ability to perform mouth examination (ME).

    Procedure: A cross-sectional study was conducted among patients with FA (between 6 and 16 years) and their parents. Read More

    The cost of major head and neck cancer surgery.
    N Z Med J 2017 May 12;130(1455):111-119. Epub 2017 May 12.
    Wellington Regional Plastic, Maxillofacial and Burns Unit, Hutt Hospital; and Gillies McIndoe Research Institute, Wellington.
    Aim: This study quantified the cost of major head and neck cancer (HNC) surgery.

    Methods: Consecutive patients undergoing major HNC surgery between July 2007 and June 2012 were identified from our head and neck database. Patient demographics, tumour type, site, stage and types of resection and reconstruction, length of stay and surgical complications occurring within six months of initial surgery were retrospectively analysed. Read More

    Analysis of risk factors for oral cavity and oropharynx cancer in the authors' own material.
    Otolaryngol Pol 2017 Apr;71(2):23-28
    Klinika Otolaryngologii i Onkologii Laryngologicznej II Katedry Otolaryngologii UM w Łodzi Kierownik: prof. dr hab. med. J. Olszewski.
    Introduction: The aim of the study was to analyse the risk factors for oral cavity and oropharynx cancer in peopled examined under the Head and Neck Cancer Awareness Week in 2016, Lodz.

    Material And Methods: In Lodz, 21st September 2016, under the Head and Neck Cancer Awareness Week, 106 people, including 67 women aged 29-77 and 39 men aged 23-84, underwent preventive examinations in the hospital department. Prior to the laryngological examination, the patients were asked to answer questions that referred to their education, medical case history, symptoms, smoking habits with the number of cigarettes per day, alcohol intake, the number of lifetime sexual partners, oral sex engagement, incidents of head and neck cancer in the family history. Read More

    In vitro and in vivo anticancer activity of posterior salivary gland toxin from the cuttlefish Sepia pharaonis, Ehrenberg (1831).
    Chem Biol Interact 2017 Jun 4;272:10-20. Epub 2017 May 4.
    Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, 603 103, Tamil Nadu, India. Electronic address:
    Posterior salivary gland (PSG) toxins are high molecular weight toxins secreted by cephalopods and gastropods which possess immense potentials in biomedical applications. In the present study, the biomedical potentials of the PSG toxin from the cuttlefish, S. pharaonis was determined in vitro and in vivo. Read More

    Congenital amelanotic melanoma in a crossbred heifer calf.
    J Vet Diagn Invest 2017 Apr 1:1040638717706399. Epub 2017 Apr 1.
    Departments of Veterinary Clinical Sciences (Winslow, Gilliam), Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK.
    A large, pedunculated cutaneous mass protruding from the left flank fold and an enlarged left prefemoral lymph node were found on examination of a 3-d-old crossbred Aberdeen Angus heifer. The calf was asymptomatic aside from peripheral lymphadenopathy, and the mass, along with the left prefemoral lymph node, was surgically excised. Histologic examination of the mass and the lymph node revealed a homogeneous population of neoplastic cells that stained positively with immunohistochemical stains S100 and melan A, supporting a diagnosis of congenital amelanotic melanoma with nodal metastasis. Read More

    Oral and Cutaneous Lymphomas other than Mycosis Fungoides and Sézary Syndrome in a Mexican Cohort: Recategorization and Evaluation of International Geographical Disparities.
    Indian J Dermatol 2017 Mar-Apr;62(2):158-167
    Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, City, Mexico; Division of Pathology, Instituto Nacional de Cancerología, Mexico City, Mexico.
    Background: Nonmycosis fungoides/Sézary syndrome (non-MF/SS) primary cutaneous lymphomas (PCL) are currently categorized under the 2005-World Health Organization/European Organization for Research and Treatment of Cancer (WHO-EORTC) classification for PCL. These differ in behavior from secondary cutaneous lymphomas (SCL) and to lymphomas limited to the oral cavity (primary oral lymphomas [POL]) both categorized under the 2016-WHO classification for lymphoid neoplasms.

    Aims: This study aims to report the first series of non-MF/SS PCL, SCL, and POL in a Mexican cohort, examine the applicability of current classification systems and compare our findings with those from foreign cohorts. Read More

    Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge.
    Diagn Pathol 2017 Apr 5;12(1):32. Epub 2017 Apr 5.
    Postgraduate Program in Dentistry, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
    Background: Oral squamous cell carcinoma (OSCC) accounts over 90% of malignant neoplasms of the oral cavity. This pathological entity is associated to a high mortality rate that has remained unchanged over the past decades. Tumour-associated macrophages (TAMs) are believed to have potential involvement in OSCC progression. Read More

    Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma.
    Tumour Biol 2017 Apr;39(4):1010428317695527
    1 School of Dentistry, Federal University of Goiás, Goiânia, Brazil.
    To investigate hypoxia-induced factor-1 alpha expression in distinct oral squamous cell carcinoma subtypes and topographies and correlate with clinicopathological data. Hypoxia-induced factor-1 alpha expression was assessed by immunohistochemistry in 93 cases of OSCC. Clinical and histopathological data were reviewed from medical records. Read More

    High HMGA2 Expression Correlates with Reduced Recurrence-free Survival and Poor Overall Survival in Oral Squamous Cell Carcinoma.
    Anticancer Res 2017 04;37(4):1891-1899
    Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan, R.O.C.
    Background/aim: High-mobility group AT-hook 2 (HMGA2) is an architectural transcription factor that is expressed in many human neoplasms. Oral squamous cell carcinoma (OSCC) is one of the leading cancers in the world, particularly in Southeast Asia. In this study, the expression level of HMGA2 was determined on tissue microarray of OSCC and its correlation with prognosis of patients was studied. Read More

    Agreement Between Cytology and Histopathology for Regional Lymph Node Metastasis in Dogs With Melanocytic Neoplasms.
    Vet Pathol 2017 Jul 27;54(4):579-587. Epub 2017 Mar 27.
    1 Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
    Melanocytic neoplasms are common in dogs and frequently occur within the oral cavity or in haired skin. The behavior of melanocytic neoplasms is variable and depends on tumor location, size, and histopathologic features. This study compared cytopathology and histopathology of 32 lymph nodes from 27 dogs diagnosed with melanocytic neoplasms. Read More

    Determining the epidemiologic, outcome, and prognostic factors of oral malignant melanoma by using the Surveillance, Epidemiology, and End Results database.
    J Am Dent Assoc 2017 May 18;148(5):288-297. Epub 2017 Mar 18.
    Background: The authors conducted a retrospective analysis to determine the epidemiologic, outcome, and prognostic factors in patients with oral malignant melanoma (OMM).

    Methods: The authors used the US National Cancer Institute's Surveillance, Epidemiology, and End Results database to analyze patients with OMM from 1973 to 2012. Study variables included age, sex, race, decade of diagnosis, extent of disease, tumor size, treatment modality, and socioeconomic status (SES). Read More

    [Expressions and clinical significance of TGF-βRII and NF-κB in oral squamous cell carcinoma].
    Shanghai Kou Qiang Yi Xue 2016 Dec;25(6):729-733
    Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Stomatology, Chongqing Medical University; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education. Chongqing 401147, China.
    Purpose: To investigate the expression of nuclear factor κappa-B (NF-κB) and transforming growth factor β receptor II (TGF-βRII) and their clinical pathological significance in oral squamous cell carcinoma(OSCC).

    Methods: The expression of NF-κB and TGF-βRII in 60 OSCC samples, 20 adjacent tissues, 29 metastatic lymph nodes and 10 non-metastatic lymph nodes were detected by immunohistological method. Statistical analysis was performed with SPSS 20. Read More

    Overexpression of KAI1/CD82 suppresses in vitro cell growth, migration, invasion and xenograft growth in oral cancer.
    Mol Med Rep 2017 Apr 9;15(4):1527-1532. Epub 2017 Feb 9.
    State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.
    KAI1/CD82 is a metastatic suppressor gene in human prostate cancer and several other types of cancer in humans. The present study aimed to examine the role of the overexpression of KAI1 in the progression of oral cancer. Human KAI1/CD82 cDNA was transfected into OSCC‑15 and 293T cell lines, and its effects on OSCC‑15 cell proliferation, invasion and apoptosis were assessed by performing a 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay, Matrigel invasion and Annexin V‑FITC staining, respectively. Read More

    SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7.
    Exp Cell Res 2017 Mar 22;352(2):357-363. Epub 2017 Feb 22.
    Department of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan. Electronic address:
    Signal-induced proliferation-associated protein 1 (SIPA1) is known to be a GTPase activating protein. Overexpressed SIPA1 is related to metastatic progression in breast and prostate cancers; however, the relevance of SIPA1 in oral squamous cell carcinoma (OSCC) is still unknown. The aim of this study was to examine SIPA1 expression and its functional mechanisms in OSCC. Read More

    [Oral cancer: Risk factors and management].
    Presse Med 2017 Mar 21;46(3):320-330. Epub 2017 Feb 21.
    CHU de Tours, hôpital Trousseau, université François-Rabelais de Tours, service de chirurgie maxillo-faciale et plastique de la face, avenue de la République, 37170 Chambray-lès-Tours, France.
    Oral cavity is the most frequent anatomical subsite of upper aero-digestive tract malignancies. Squamous cell carcinoma is the most common histological type and totalizes more than 95% of oral cancer. Main risk factors are tobacco and alcohol exposure and also potentially malignant lesions. Read More

    CD44+ cancer cell-induced metastasis: A feasible neck metastasis model.
    Eur J Pharm Sci 2017 Apr 13;101:243-250. Epub 2017 Feb 13.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology, Key Laboratory of Oral Biomedicine Ministry of Education, Wuhan University, Wuhan, China; Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, China. Electronic address:
    Neck metastasis of oral squamous cell carcinoma (OSCC) indicates a poor prognosis. Few neck metastasis models are currently available for drug trials and clinical research on OSCC. This study constructed a feasible animal model of neck metastasis by using CD44+ stem cell-like cancer cells. Read More

    Cribriform adenocarcinoma of the minor salivary gland arising in the tonsil with metastasis to a cervical lymph node: A case report with description of fine needle aspiration cytology.
    Diagn Cytopathol 2017 May 16;45(5):468-471. Epub 2017 Feb 16.
    Department of Pathology, University of Kansas School of Medicine, Kansas City, Kansas, 66160.
    Cribriform adenocarcinoma of minor salivary gland (CAMSG) is a rare tumor of the head and neck. We report a case of a 70-year-old female who presented with a 4-5-month history of a left neck mass. CT scan of the neck showed a left neck mass just inferior to the angle of the mandible and left tonsillar prominence. Read More

    Reciprocal regulation of miR-1254 and c-Myc in oral squamous cell carcinoma suppresses EMT-mediated metastasis and tumor-initiating properties through MAPK signaling.
    Biochem Biophys Res Commun 2017 Mar 1;484(4):801-807. Epub 2017 Feb 1.
    Department of Oral Surgery, The Union Hospital of Fujian Medical University, Fuzhou, 350001, Fujian, PR China.
    Aim: This study aimed to determine the effect of miR-1254 on oral squamous cell carcinoma (OSCC) metastasis and the specific mechanism involved.

    Methods: The metastatic properties of OSCC cells were analyzed by transwell assays. The tumor-initiating properties of OSCC cells were analyzed by tumor sphere formation assays. Read More

    Squamous Cell Carcinoma of the Lip-A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction.
    Dermatol Surg 2017 Apr;43(4):494-506
    *Department of Dermatology, University of Massachusetts, Worcester, Massachusetts; †Department of Medicine, Eastern Virginia Medical School, Norfolk, Virginia; ‡Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
    Background: The lip is an anatomic junction for 2 disparate groups of cancer. Cutaneous squamous cell carcinoma (cSCC) is a common malignancy with a favorable prognosis, whereas oral-mucosal squamous cell carcinoma (omSCC) is associated with significantly higher rates of nodal disease and worse outcomes. The squamous cell carcinoma of the lip (lip SCC) is more aggressive than cSCC but less aggressive than omSCC. Read More

    Autoimmune Disease Manifestations in the Oral Cavity.
    Surg Pathol Clin 2017 Mar 28;10(1):57-88. Epub 2016 Dec 28.
    Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida, 1395 Center Drive, Gainesville, FL 32610, USA.
    Immune-related disorders of the oral cavity may occur as primary disease process, secondary to systemic disease or neoplasm, or as a reaction to medications and other agents. The entities represented within this group may vary significantly by severity, clinical presentation, microscopic presentation, and special testing results. The selected immune-related conditions of the oral cavity in this article are categorized and presented by their prototypical tissue reaction patterns: vesiculobullous, including acantholytic and subepithelial separation; psoriasiform; spongiotic; and lichenoid reaction patterns. Read More

    Successful multimodal treatment of intraoral salivary duct carcinoma in a patient with multiple lymph node metastases: a case report.
    World J Surg Oncol 2017 Jan 10;15(1):18. Epub 2017 Jan 10.
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, 2630 Sugitani, Toyama city, Toyama, 930-0194, Japan.
    Background: Salivary duct carcinoma (SDC) is a high-grade salivary gland malignancy that is associated with an aggressive clinical behavior and poor prognosis. Herein, we report on a long surviving case of SDC of the minor salivary gland with multiple lymph node metastases (LNMs).

    Case Presentation: An 83-year-old woman presented with a history of lymphadenopathy in the right side of the neck and recent onset and rapid growth of a mass in the right buccal region. Read More

    Clinics, prognosis and new therapeutic options in patients with mucosal melanoma: A retrospective analysis of 75 patients.
    Medicine (Baltimore) 2017 Jan;96(1):e5753
    aDepartment for Dermatology and Allergy, Skin Cancer Center Hannover (HTZH), Hannover Medical School bOffice for Dermatology, Allergy and Venerology, Seelze, Germany.
    Mucosal melanomas represent a rare entity with different risk factors and molecular features compared to cutaneous melanomas. They arise most commonly from mucosal surfaces in the head/neck region, the female genital tract (FGT) and the anorectal region. The aim of this study was to evaluate clinics, prognosis, and treatment options of patients with mucosal melanoma, in particular with regard to different primary sites. Read More

    Oral health-related quality of life after prosthetic rehabilitation in patients with oral cancer: A longitudinal study with the Liverpool Oral Rehabilitation Questionnaire version 3 and Oral Health Impact Profile-14 questionnaire.
    Indian J Cancer 2016 Apr-Jun;53(2):256-260
    Department of Dental and Prosthetic Surgery, Tata Memorial Hospital, Mumbai, Maharashtra, India.
    Background: Prosthodontic rehabilitation helps to improve the oral health-related quality of life (OHRQOL). The Liverpool Oral Rehabilitation Questionnaire (LORQ) and Oral Health Impact Profile (OHIP) are specific tools that measure OHRQOL.

    Objective: The primary objective of this study was to assess the impact of oral rehabilitation on patients' OHRQOL following treatment for cancer of oral cavity using LORQ version 3 (LORQv3) and OHIP-14 questionnaire. Read More

    Clinico-pathological factors affecting lymph node yield in Indian patients with locally advanced squamous cell carcinoma of mandibular Gingivo-Buccal sulcus.
    Indian J Cancer 2016 Apr-Jun;53(2):239-243
    Department of Pathology, KLE VK Institute of Dental Sciences, KLE University, Belgaum, Karnataka, India.
    Aim: Lymph node yield (LNY) is a valid marker of prognosis in oral cancer. Precise estimation of LNY in Indian patients with T3/T4 gingivobuccal sulcus squamous cell carcinoma (GBS-SCC) has not been well documented. Hence, the primary objective of the study was to determine the LNY in patients with T3/T4 SCC of mandibular GBS, and the secondary objective was to study the association of LNY with clinicopathological factors such as tumor thickness, histological differentiation, number of positive nodes, and extracapsular spread (ECS). Read More

    Brain metastasis from nonnasopharyngeal head and neck squamous cell carcinoma: A case series and review of literature.
    J Cancer Res Ther 2016 Jul-Sep;12(3):1160-1163
    Department of Radiation Oncology, Tata Memorial Center, Mumbai, Maharashtra, India.
    Background: Brain metastasis from primary head and neck squamous cell carcinoma (HNSCC) is infrequent and probably under-reported thereby leading to paucity of information.

    Methods: Archives of two institutes in India were studied from 2005 to 2013 and relevant information regarding patient demographics, treatment details, and follow-up was obtained for patients having brain metastasis (BM) from HNSCC. Data were analyzed using SPSS software version 20 (IBM Corporation, NY, USA). Read More

    The natural history and patterns of metastases from mucosal melanoma: an analysis of 706 prospectively-followed patients.
    Ann Oncol 2017 Apr;28(4):868-873
    Department of Renal Cancer & Melanoma, Peking University Cancer Hospital & Institute, Beijing.
    Background: We examined whether mucosal melanomas are different in their clinical course and patterns of metastases when arising from different anatomic sites. Our hypothesis was that metastatic behavior would differ from primary mucosal melanomas at different anatomical sites.

    Patients And Methods: Clinical and pathological data from 706 patients were compared for their stage distribution, patterns of metastases, CKIT/BRAF mutation status, and overall survival for different anatomical sites. Read More

    Transforming growth factor-β1 suppresses bone morphogenetic protein-2-induced mesenchymal-epithelial transition in HSC-4 human oral squamous cell carcinoma cells via Smad1/5/9 pathway suppression.
    Oncol Rep 2017 Feb 28;37(2):713-720. Epub 2016 Dec 28.
    Division of Cellular Biosignal Sciences, Department of Biochemistry, Iwate Medical University, Yahaba-cho, Iwate 028-3694, Japan.
    Squamous cell carcinoma is the most common cancer in the oral cavity. We previously demonstrated that transforming growth factor-β1 (TGF-β1) promotes the epithelial-mesenchymal transition (EMT) of human oral squamous cell carcinoma (hOSCC) cells; however, it remains to be clarified whether the TGF-β superfamily member bone morphogenetic protein (BMP) affects this process in hOSCC cells. Here, we examined the independent and collective effects of TGF-β1 and BMP-2 on EMT and mesenchymal‑epithelial transition (MET) in a panel of four hOSCC cell lines. Read More

    Recent Trends in Oral Cavity Cancer Research Support in the United States.
    J Dent Res 2017 Jan;96(1):17-22
    6 Department of Oral Health Sciences and the Center for Oral Health Research, Medical University of South Carolina, Charleston, SC, USA.
    The objectives were to characterize oral cavity cancer (OCC) funding from the National Institutes of Health (NIH) with a secondary aim of comparing NIH support provided to OCC and other malignancies. NIH awards supporting OCC inquiry from 2000 to 2014 were accessed from the NIH RePORTER database. These data were used to evaluate temporal trends and the role of human papilloma virus and to determine the academic training and professional profiles of the principal investigators. Read More

    A Case of Hepatocellular Carcinoma Presenting as a Gingival Mass.
    Korean J Gastroenterol 2016 Dec;68(6):321-325
    Department of Pathology, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
    Oral metastatic tumor, which is uncommon and represents less than 1% of malignant oral neoplasms, usually arises from a primary mucosal or cutaneous cancer located in the head and neck regions. Metastasis of hepatocellular carcinoma (HCC) to the oral cavity, especially to gingiva, is extremely rare. A 50-year-old man, who was a chronic alcoholic and hepatitis B virus carrier, presented with abdominal distension and weight loss for the past 3 months. Read More

    Vascular alterations after photodynamic therapy mediated by 5-aminolevulinic acid in oral leukoplakia.
    Lasers Med Sci 2017 Feb 21;32(2):379-387. Epub 2016 Dec 21.
    General Pathology Department, School of Dentistry, University of São Paulo, Av. Prof Lineu Prestes, 2227 - Cidade Universitária, 05508-000, São Paulo, SP, Brazil.
    Impairment of vascular functions after photodynamic therapy (PDT) is frequently associated with tumor remission and is considered one of the main antineoplastic PDT effects. Vascular alterations in oral leukoplakia (OL) treated with PDT have not yet been described. The aim of this study was to evaluate the effect of topical 5-ALA-mediated PDT on the vascular network of 4NQO-induced OL in rats. Read More

    FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi-institutional study of 184 cases.
    Cancer 2017 Feb 21;125(2):91-103. Epub 2016 Dec 21.
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Background: Secondary malignancies of salivary glands (SMSGs) are among the most common malignant neoplasms to involve the salivary glands. Fine-needle aspiration biopsy (FNAB) of SMSG can present diagnostic challenges. The current report presents the largest such FNAB series to date. Read More

    MicroRNA‑375 inhibits oral squamous cell carcinoma cell migration and invasion by targeting platelet‑derived growth factor‑A.
    Mol Med Rep 2017 Feb 19;15(2):922-928. Epub 2016 Dec 19.
    Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
    MicroRNA‑375 (miR‑375) serves an important role in cancer development and growth. However, little is known about the role of miR‑375 in the regulation of oral squamous cell carcinoma (OSCC) metastasis and invasion. The present study measured the expression levels of miR‑375 in Tca8113, UM2, UM1 and CAL‑27 cell lines, using reverse transcription‑quantitative polymerase chain reaction. Read More

    FDG PET/CT in Carcinoma of the Tongue With Bilateral Adrenal Metastases.
    Clin Nucl Med 2017 Feb;42(2):123-124
    From the Departments of *Nuclear Medicine, and †Otolaryngology and Rhinology, All India Institute of Medical Sciences, New Delhi, India.
    Squamous cell carcinoma is the most common malignant neoplasm of the oral cavity, and it contributes approximately 90% of all oral malignancies. We present a case of a squamous cell carcinoma of the tongue with rare site of bilateral adrenal metastases on F-FDG PET/CT with response evaluation after chemotherapy. Read More

    Targeting metastasis-initiating cells through the fatty acid receptor CD36.
    Nature 2017 01 7;541(7635):41-45. Epub 2016 Dec 7.
    Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.
    The fact that the identity of the cells that initiate metastasis in most human cancers is unknown hampers the development of antimetastatic therapies. Here we describe a subpopulation of CD44(bright) cells in human oral carcinomas that do not overexpress mesenchymal genes, are slow-cycling, express high levels of the fatty acid receptor CD36 and lipid metabolism genes, and are unique in their ability to initiate metastasis. Palmitic acid or a high-fat diet specifically boosts the metastatic potential of CD36(+) metastasis-initiating cells in a CD36-dependent manner. Read More

    Tumorigenicity and Validity of Fluorescence Labelled Mesenchymal and Epithelial Human Oral Cancer Cell Lines in Nude Mice.
    Biomed Res Int 2016 13;2016:4897986. Epub 2016 Nov 13.
    Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kong.
    Tumorigenicity and metastatic activity can be visually monitored in cancer cells that were labelled with stable fluorescence. The aim was to establish and validate local and distant spread of subcutaneously previously injected fluorescence transduced human tongue cancer cell lines of epithelial and mesenchymal phenotype in nude mice. A total of 32 four-week-old male athymic Balb/c nude mice were randomly allocated into 4 groups (n = 8). Read More

    Outcomes and prognostic factors for squamous cell carcinoma of the oral tongue in young adults: a single-institution case-matched analysis.
    Eur Arch Otorhinolaryngol 2017 Mar 8;274(3):1683-1690. Epub 2016 Dec 8.
    Département de Radiothérapie, Gustave Roussy, Université Paris-Saclay, Villejuif, 94805, France.
    There is controversy regarding prognosis and treatment of young patients with oral cavity cancer compared to their older counterparts. We conducted a retrospective case-matched analysis of all adult patients younger than 40 years and treated at our institution for a squamous cell carcinoma of the oral cavity. Only non-metastatic adult patients (age >18) with oral tongue cancer were eventually included and matched 1:1 with patients over 40 years of age, at least 20 years older than the cases, with same T and N category and treatment period. Read More

    Neck dissection versus "watchful-waiting" in early squamous cell carcinoma of the tongue our experience on 127 cases.
    Surg Oncol 2016 Dec 21;25(4):401-404. Epub 2016 Sep 21.
    Department of Maxillo-Facial Surgery, University of Naples, "Federico II", Naples, Italy.
    Background: Early oral squamous cell carcinoma (EOSCC) represents about 90% of the oral cancers especially in older males. The etiology is multifactorial, strongly related to tobacco and alcohol abuse, but also infective agents, Human papillomaviruses (HPV16-18), genetic factors and pre-neoplastic lesions seem to be implicated. There is no consensus in the literature for the treatment of early squamous cell carcinoma of the tongue (stages I-II); both an elective neck dissection policy and a watchful-waiting policy have their proponents in the different centers. Read More

    Receptor tyrosine kinase amplification is predictive of distant metastasis in patients with oral squamous cell carcinoma.
    Cancer Sci 2017 Feb;108(2):256-266
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
    This study aimed to clarify the genomic factors associated with the diagnosis and prognosis of oral squamous cell carcinoma via next-generation sequencing. We evaluated data from 220 cases of oral squamous cell carcinoma. Genomic DNA was eluted using formalin-fixed, paraffin-embedded samples, and targeted resequencing of 50 cancer-related genes was performed. Read More

    Sentinel lymph node biopsy for early oral cancers: Westmead Hospital experience.
    ANZ J Surg 2017 Jan 23;87(1-2):65-69. Epub 2016 Nov 23.
    Head and Neck Cancer Service, Crown Princess Mary Cancer Centre, Sydney, New South Wales, Australia.
    Background: Sentinel lymph node biopsy (SLNB) has become an alternative option to elective neck dissection (END) for early oral cavity squamous cell carcinoma (OCSCC) outside of Australia. We sought to assess the technical feasibility of SLNB and validate its accuracy against that of END in an Australian setting.

    Methods: We performed a prospective cohort study consisting of 30 consecutive patients with cT1-2 N0 OCSCC referred to the Head and Neck Cancer Service, Westmead Hospital, Sydney, between 2011 and 2014. Read More

    Oral and gastrointestinal symptomatic metastases as initial presentation of lung cancer.
    BMJ Case Rep 2016 Nov 18;2016. Epub 2016 Nov 18.
    Department of Medical Oncology, Christian Medical College and Hospital, Vellore, India.
    Metastasis to the tongue, duodenum or pancreas from primary lung cancer is uncommon. Primary lung cancer presenting with symptoms related to metastases at these sites, at initial presentation is extremely rare. We report a 45-year-old man with disseminated lung malignancy who presented with dyspepsia, melena, symptoms due to anaemia and swelling in the tongue. Read More

    May High MMP-2 and TIMP-2 Expressions Increase or Decrease the Aggressivity of Oral Cancer?
    Pathol Oncol Res 2017 Jan 16;23(1):197-206. Epub 2016 Nov 16.
    Department of Oral Pathology, Manipal College of Dental Sciences, Manipal University, Manipal, 576104, India.
    Matrix metalloproteinases-2 (MMP-2) and the tissue inhibitor of metalloproteinase-2 (TIMP-2), may presumably have an important role on the invasion and metastatic spread of malignancies attributed to an uncontrolled degradation of the extracellular matrix (ECM). A retrospective chart analysis was carried out to study the expression of MMP-2 and TIMP-2 on the archival samples of oral squamous cell carcinoma (OSCC) (n = 30) and normal mucosa (n = 10) by immunohistochemistry and compared with the clinicopathologic parameters of cases. Both MMP-2 and TIMP-2 expressions showed a positive correlation with the grades, stages and metastatic capacities of tumors (Spearman's correlation, p < 0. Read More

    Management of neck metastases in head and neck cancer: United Kingdom National Multidisciplinary Guidelines.
    J Laryngol Otol 2016 May;130(S2):S161-S169
    Department of Clinical Oncology,St James's Institute of Oncology,Leeds,UK.
    This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. A rational plan to manage the neck is necessary for all head and neck primaries. With the emergence of new level 1 evidence across several domains of neck metastases, this guideline will identify the evidence-based recommendations for management. Read More

    Investigation and management of the unknown primary with metastatic neck disease: United Kingdom National Multidisciplinary Guidelines.
    J Laryngol Otol 2016 May;130(S2):S170-S175
    Department of Otolaryngology - Head and Neck Surgery,Guy's and St Thomas' Hospital NHS Foundation Trust,Department of Otolaryngology - Head and Neck Surgery,Guy's, King's and St Thomas' Medical and Dental School,London,UK.
    This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. It discusses the evidence base pertaining to the management of metastatic neck disease in the setting of an unknown primary and provides recommendations on the work up and management for this group of patients receiving cancer care. Recommendations • All patients presenting with confirmed cervical lymph node metastatic squamous cell carcinoma and no apparent primary site should undergo: ○ Positron emission tomography-computed tomography whole-body scan. Read More

    Study of some invasiveness markers as pathogenic factors in oral pseudoepitheliomatous hyperplasia.
    Rom J Morphol Embryol 2016 ;57(2 Suppl):775-783
    Department of Pathology, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, Romania;
    Pseudoepitheliomatous hyperplasia is a benign reactivated epithelial lesion secondary to another pathology, whose incidence is difficult to establish. There still exist controversies regarding the origin and pathogenesis of these lesions. For this purpose, we performed an immuno-histochemical study upon 20 cases of oral pseudoepitheliomatous hyperplasia associated with inflammatory and neoplastic conditions, investigating a series of markers with a possible pathogenic potential in developing this type of lesions. Read More

    The CCL2-CCR2 Axis in Lymph Node Metastasis From Oral Squamous Cell Carcinoma: An Immunohistochemical Study.
    J Oral Maxillofac Surg 2017 Apr 8;75(4):742-749. Epub 2016 Oct 8.
    Professor, Division of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
    Purpose: Cytokine or chemokine networks involve lymphatic and distant metastasis of various malignancies, including oral squamous cell carcinoma (OSCC). Immunohistochemical analysis was used to investigate the contribution of the axis of the CC chemokine receptor-2 (CCR2) and the CC chemokine receptor-2 ligand (CCL2) to lymphatic metastasis, particularly the relation between primary OSCC and marginal sinus histiocytosis in regional lymph nodes.

    Materials And Methods: Thirteen metastasis-free cases, 15 metastatic cases at resection of primary tumor resection, and 13 postresection metastasis cases were examined. Read More

    Immunoexpression of Epithelial Mesenchymal Transition Proteins E-Cadherin, β-Catenin, and N-Cadherin in Oral Squamous Cell Carcinoma.
    Int J Surg Pathol 2016 Dec 15;24(8):696-703. Epub 2016 Jun 15.
    KLE University's JN Medical College, Belgaum, Karnataka, India.
    Aims Epithelial mesenchymal transition (EMT) is a crucial process for acquisition of malignant phenotype, aggressiveness, and metastatic capacity in neoplasms. It is characterized by loss of epithelial markers and gain of mesenchymal markers. Studies on EMT and its potential association with the histological grading are sparse in oral squamous cell carcinoma (OSCC). Read More

    Effects of Radioiodine Treatment on Salivary Gland Function in Patients with Differentiated Thyroid Carcinoma: A Prospective Study.
    J Nucl Med 2016 Nov 23;57(11):1685-1691. Epub 2016 Jun 23.
    Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Complaints of a dry mouth (xerostomia) and sialoadenitis are frequent side effects of radioiodine treatment in differentiated thyroid cancer (DTC) patients. However, detailed prospective data on alterations in salivary gland functioning after radioiodine treatment ((131)I) are scarce. Therefore, the primary aim of this study was to prospectively assess the effect of high-activity radioiodine treatment on stimulated whole saliva flow rate. Read More

    Cervical metastasis in squamous cell carcinoma of the hard palate and maxillary alveolus.
    Ear Nose Throat J 2016 Oct-Nov;95(10-11):E6-E11
    Division of Otolaryngology, Department of Surgery, Cooper University Hospital, 3 Cooper Plaza, Suite 411, Camden, NJ 08034, USA.
    We conducted a retrospective study to determine the incidence and treatment outcomes of neck metastases in patients with squamous cell carcinoma (SCC) of the hard palate and/or maxillary alveolus after surgical excision of the primary tumor. We also sought to identify any risk factors for recurrence. Our study population was made up of 20 patients-9 men and 11 women, aged 46 to 88 years (mean: 72. Read More

    Use of NRP1, a novel biomarker, along with VEGF-C, VEGFR-3, CCR7 and SEMA3E, to predict lymph node metastasis in squamous cell carcinoma of the tongue.
    Oncol Rep 2016 Nov 21;36(5):2444-2454. Epub 2016 Sep 21.
    First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan.
    Lymph node (LN) metastasis has been suggested as a major prognostic factor for oral cancer. Knockdown of the growth factors and receptors involved in these metastatic mechanisms could significantly reduce LN metastasis and improve the survival of oral cancer patients after treatment. The present study, therefore, aimed to evaluate the expression levels of the following growth factors and receptors in squamous cell carcinoma (SCC) of the tongue: the vascular endothelial growth factor (VEGF)‑C and VEGF‑D, which bind to the cell surface tyrosine kinase receptor VEGF receptor‑3 (VEGFR‑3); C‑C motif chemokine receptor 7 (CCR7); neuropilin (NRP)1 and NRP2; and semaphorin 3E (SEMA3E). Read More

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