5,042 results match your criteria Metastatic Neoplasms to the Oral Cavity


Prognostic Roles of SCC Antigen, CRP and CYFRA 21-1 in Oral Cavity Squamous Cell Carcinoma.

Anticancer Res 2019 Apr;39(4):2025-2033

Department of Otolaryngology - Head & Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C.

Background/aim: Tumor-related and inflammation-related markers were reported to be prognostic in cancer patients. In this study, we evaluated squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21-1) and C-reactive protein (CRP) simultaneously in oral cavity squamous cell carcinoma (OSCC) patients.

Patients And Methods: Two hundred and forty-six newly diagnosed OSCC patients were retrospectively recruited between December 2010 and December 2016. Read More

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http://dx.doi.org/10.21873/anticanres.13313DOI Listing
April 2019
1 Read

Current Challenges in the Staging of Oral Cancer.

Authors:
Martin J Bullock

Head Neck Pathol 2019 Mar 18. Epub 2019 Mar 18.

Department of Pathology, Division of Anatomical Pathology, Queen Elizabeth II Health Sciences Centre, Dalhousie University, Room 716-5788 University Avenue, Halifax, NS, B3H 1V8, Canada.

In the recently published 8th edition of the AJCC Cancer Staging Manual, new pathological elements are required for the N and T category determinations for oral cavity cancers. This includes determination of depth of tumor invasion and assessment of metastatic lymph nodes for extranodal extension. Although definitions and some guidance are provided for the interpretation of these elements, pathologists frequently encounter ambiguous situations that may result in interobserver and intraobserver variability. Read More

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http://dx.doi.org/10.1007/s12105-019-01014-4DOI Listing

Assessment of salivary endothelin-1 in patients with leukoplakia, submucous fibrosis, oral cancer and healthy individuals - a comparative study.

J Stomatol Oral Maxillofac Surg 2019 Mar 9. Epub 2019 Mar 9.

Faculty of Dental Sciences, Ramaiah University of Applied Sciences, India.

Background: Oral cancer is one of the highly prevalent cancers worldwide being. According to data of GLOBOCAN 2018, the estimated incidence, mortality and 5-year survival rates due to lip, oral cavity and salivary gland cancer in world is (2.0%), (0. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.02.024DOI Listing
March 2019
2 Reads

Thermochemoradiotherapy Using Superselective Intra-arterial Infusion for Patients With Oral Cancer With Cervical Lymph Node Metastases.

Anticancer Res 2019 Mar;39(3):1365-1373

Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Aim: We aimed to retrospectively investigate the outcomes and pathological effects of retrograde superselective intra-arterial chemoradiotherapy (IACRT) combined with hyperthermia on metastatic lymph nodes of patients with oral squamous cell carcinoma.

Patients And Methods: Patients with lymph node metastasis from oral cancer were treated with IACRT using cisplatin plus docetaxel combined with hyperthermia prior to surgical removal 8 weeks after completion of IACRT and hyperthermia. The locoregional control and overall survival rates were calculated using the Kaplan-Meier method. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13250DOI Listing
March 2019
10 Reads

Probability of carcinogenesis due to involved field and involved site radiation therapy techniques for supra- and infradiaphragmatic Hodgkin's disease.

Phys Med 2019 Jan 3;57:100-106. Epub 2019 Jan 3.

Department of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 2208, Heraklion 71003, Crete, Greece.

Purpose: To estimate the second cancer risk associated with Hodgkin Lymphoma (HL) radiotherapy at supradiaphragmatic or infradiaphragmatic region, using the involved field (IFRT) and the involved site radiotherapy (ISRT).

Materials And Methods: IFRT and ISRT treatment plans were created for twenty HL patients. Three dimensional plans (3DRT) were employed for all patients. Read More

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http://dx.doi.org/10.1016/j.ejmp.2018.12.036DOI Listing
January 2019
2 Reads

[A Case of Advanced Sigmoid Colon Cancer That Was Resected after Chemoradiation Therapy Following Ineffective Chemotherapy].

Gan To Kagaku Ryoho 2018 Dec;45(13):2027-2029

Dept. of Surgery, NTT West Osaka Hospital.

We report a case of advanced sigmoid colon cancer that was resected after chemoradiation therapy(CRT)following ineffective chemotherapy. A 59-year-old woman harbored a lower abdominal tumor the size of an infant's head and was diagnosed with a huge sigmoid colon cancer with invasion to the urinary bladder and metastases to the para-aortic lymph nodes. The patient received 2 courses of modified FOLFOX6(mFOLFOX6)plus cetuximab therapy, which was assessed as ineffective; She then received CRTwith 50. Read More

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December 2018
1 Read

[Indication for Radiotherapy for Breast Cancer Metastasis to the Skull Base Accompanied by Cranial Nerve Palsies].

Gan To Kagaku Ryoho 2018 Dec;45(13):1806-1808

Dept. of Surgery, Southern Tohoku General Hospital.

Distant metastasis to the skull base region frequently manifests various cranial nerve symptoms and reduces patients' quality of life(QOL). We report a 62-year-old woman with skull base metastasis of breast cancer, whose condition clinically improved following palliative radiotherapy. The patient presented to our hospital with hoarseness. Read More

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December 2018
2 Reads

Time intervals from first symptom to diagnosis for head and neck cancers: An analysis of linked patient reports and medical records from the UK.

Cancer Epidemiol 2019 Apr 19;59:37-45. Epub 2019 Jan 19.

Hull York Medical School, Allam Medical Building, University of Hull, Hull, HU6 7RX, United Kingdom. Electronic address:

Background: England has significantly higher mortality risks due to Head and Neck Cancer (HNC) compared with other European countries. Early diagnosis is important as it is likely to increase early-stage diagnosis and improve survival and better quality of life. This study sought to improve understanding of the intervals from first symptom recognition to diagnosis for HNC and investigate associations between patient-reported symptoms and socio-demographic factors. Read More

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http://dx.doi.org/10.1016/j.canep.2019.01.008DOI Listing
April 2019
4 Reads

Improved survival among oral cancer patients: findings from a retrospective study at a tertiary care cancer centre in rural Kerala, India.

World J Surg Oncol 2019 Jan 11;17(1):15. Epub 2019 Jan 11.

Department of Surgical Oncology, Malabar Cancer Centre, Thalassery, Kerala, 670 103, India.

Background: Oral cancer is very common in India. The reported 5-year survival of such patients is around 50% after treatment with surgery and radiotherapy, much lower than most of the developed countries.

Methods: A retrospective study of a prospective database of oral cancer patients undergoing surgery from June 2009 to June 2013 was conducted. Read More

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http://dx.doi.org/10.1186/s12957-018-1550-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330462PMC
January 2019
4 Reads

Parotid incidentalomas on positron emission tomography: what is their clinical significance?

Nucl Med Commun 2019 Mar;40(3):264-269

Norwich Radiology Academy, The Cotman Centre, Norwich.

Objective And Aim: The increased use of PET/CT in cancer staging has resulted in more incidental findings in unexpected locations, making this a challenge for the radiologist interpreting the study. Our aim was to determine the frequency of parotid incidentalomas and to assess the ability of PET/CT to characterize them.

Patients And Methods: At the Norfolk and Norwich University Trust, in between October 2010 to October 2015, 4044 patients had a PET/CT examination. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000961DOI Listing
March 2019
2 Reads

Two case reports on Mandibular metastases.

Ghana Med J 2018 Sep;52(3):168-172

Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Lagos State University College of Medicine, Lagos State, Nigeria.

Metastatic tumours of the oral cavity are not common. The most common site for bone metastases in the head and neck region is the mandible. Metastatic lesion of the mandible most commonly originate from the lungs in men and breast in women, and these lesions (or tumours) usually are carcinomas rather than sarcomas. Read More

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http://dx.doi.org/10.4314/gmj.v52i3.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303547PMC
September 2018
3 Reads

Bone marrow metastases in salivary duct carcinoma of the parotid gland.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Department of Otolaryngology/HNS, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA.

Salivary duct carcinoma (SDC) is a rare and extremely aggressive salivary gland cancer. An 81-year-old woman with SDC underwent a total parotidectomy with facial nerve sacrifice and a neck dissection. Following surgery, she was diagnosed with disseminated bone marrow metastases. Read More

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http://dx.doi.org/10.1136/bcr-2018-226636DOI Listing
December 2018
3 Reads

Intraperitoneal delivery of NanoOlaparib for disseminated late-stage cancer treatment.

Int J Nanomedicine 2018 29;13:8063-8074. Epub 2018 Nov 29.

Department of Bioengineering, Northeastern University, Boston, MA, USA,

Background: PARP inhibitors, such as Olaparib, have advanced the treatment of ovarian cancer by providing patients with an effective and molecularly-targeted maintenance therapy. However, all orally-administered drugs, including Olaparib, must undergo first-pass metabolism. In contrast, a nanoparticle delivery system has the advantage of administering Olaparib directly into the peritoneal cavity for local treatment. Read More

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https://www.dovepress.com/intraperitoneal-delivery-of-nanool
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http://dx.doi.org/10.2147/IJN.S186881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278886PMC
January 2019
14 Reads

Vascular density and inflammatory infiltrate in primary oral squamous cell carcinoma and after allogeneic hematopoietic stem cell transplantation.

Ann Hematol 2019 Apr 5;98(4):979-986. Epub 2018 Dec 5.

Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124, Bari, Italy.

Hematopoietic stem cell transplantation (HSCT) recipients have been reported to have an increased risk of chronic graft versus host disease (cGVHD) and hematological and solid cancers. Oral manifestations are the first signs of cGVHD observed in the majority of patients, and oropharyngeal cancer is the most frequent secondary malignancy occurred after HSCT. In this study, we have evaluated the inflammatory infiltrate cell content and correlated with the vascular density in patients affected by primary oral squamous cell carcinoma (OSCC) from previous healthy controls and OSCC after cGVHD. Read More

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http://link.springer.com/10.1007/s00277-018-3575-3
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http://dx.doi.org/10.1007/s00277-018-3575-3DOI Listing
April 2019
24 Reads

Contribution of Promoter Genotypes to Oral Cancer Susceptibility, Recurrence and Metastasis in Taiwan.

Anticancer Res 2018 Dec;38(12):6821-6826

Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Aim: Metalloproteinase 2 (MMP2) is a multi-functional protein which has been shown to be up-regulated in patients with oral cancer, especially those with lymph node metastasis. However, the association of MMP2 genotype with oral cancer risk or metastatic behavior is unknown. This study aimed to evaluate the role of MMP2 promoter 1306 and -735 genotypes in the risk of oral cancer and metastasis. Read More

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http://dx.doi.org/10.21873/anticanres.13055DOI Listing
December 2018

Isolation and characterization of two canine melanoma cell lines: new models for comparative oncology.

BMC Cancer 2018 Dec 4;18(1):1219. Epub 2018 Dec 4.

OCR (Oncovet Clinical Research), SIRIC ONCOLille, Parc Eurasante, Rue du Dr Alexandre Yersin, F-59120, Loos, France.

Background: Metastatic melanoma is one of the most aggressive forms of cancer in humans. Among its types, mucosal melanomas represent one of the most highly metastatic and aggressive forms, with a very poor prognosis. Because they are rare in Caucasian individuals, unlike cutaneous melanomas, there has been fewer epidemiological, clinical and genetic evaluation of mucosal melanomas. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-5114-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280433PMC
December 2018
11 Reads

Acinic cell carcinoma of parotid gland with cavernous sinus metastasis: A case report.

J Cancer Res Ther 2018 Oct-Dec;14(6):1428-1430

Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.

Acinic cell carcinoma (AciCC) is a low-grade malignancy which rarely metastasizes to bone or cavernous sinuses. A 62-year-old male patient, previously treated for AciCC of right parotid with surgery and local radiotherapy, presented 10 years later with progressive visual impairment and restriction of ocular movements. Magnetic resonance imaging of the head and orbit showed an expansile lobulated mass with heterogeneous signal intensity in bilateral cavernous sinus with encasement of the internal carotid artery on both sides. Read More

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http://dx.doi.org/10.4103/0973-1482.192850DOI Listing
February 2019
22 Reads

Tongue base mucosectomy for carcinoma of unknown primary using endoscopic electrocautery: rationale for wider implementation of an institutionally restricted technique.

J Laryngol Otol 2018 Dec 20;132(12):1138-1142. Epub 2018 Nov 20.

Department of ENT, Head and Neck Surgery,Royal Sussex County Hospital,Brighton, and Head and Neck Unit,Queen Victoria Hospital,East Grinstead,UK.

Background: Cervical metastasis from an unknown primary site invariably results in pan-mucosal irradiation if a primary tumour is not identified. Transoral robotic and laser-assisted mucosectomy are valid techniques to increase diagnostic rates, but these remain restricted to certain centres. This paper describes, in detail, a technique in which mucosectomy is performed via endoscopic electrocautery. Read More

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http://dx.doi.org/10.1017/S0022215118002062DOI Listing
December 2018
26 Reads

Are elderly patients presenting with squamous cell carcinoma of the oral cavity given the appropriate treatment?

Surg Oncol 2018 Dec 2;27(4):715-721. Epub 2018 May 2.

Universitary Hospital Pitié Salpêtrière, AP-HP, Department of Maxillo-facial Surgery, 47-83 boulevard de l'hôpital, 75 651 Paris Cedex 13, France; Pierre & Marie Curie University, 4 Place Jussieu 75252 Paris Cedex 05, France.

Objectives: There is no consensus for the specific management of elderly patients presenting with oral cavity squamous cell carcinomas (OC SCC). We report our findings in the treatment of primary OC SCC, for patients of 70 years of age or more, in a French university hospital center.

Patients And Methods: One hundred and twenty five patients diagnosed between 2000 and 2010, were included retrospectively. Read More

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http://dx.doi.org/10.1016/j.suronc.2018.04.005DOI Listing
December 2018
3 Reads

Reconstruction of Defects Involving the Lip and Chin.

Facial Plast Surg Clin North Am 2019 Feb;27(1):67-83

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, 170 Manning Drive, Campus Box 7070, Chapel Hill, NC 27599, USA.

Successful perioral reconstruction is the result of consideration of both functional and esthetic goals. The lips are complex esthetic units with multiple tissue layers and distinct anatomic landmarks. Reconstruction can be difficult due to variables affecting the defect, such as size, depth, location, and involvement of adjacent subunits. Read More

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http://dx.doi.org/10.1016/j.fsc.2018.08.008DOI Listing
February 2019
22 Reads

Diffusion weighted magnetic resonance imaging is a feasible method for characterizing regional lymph nodes in canine patients with head and neck disease.

Vet Radiol Ultrasound 2019 Mar 12;60(2):176-183. Epub 2018 Nov 12.

Animal Imaging, Irving, TX, 75039.

In dogs diagnosed with solid tumors, regional lymph node involvement or evidence of distant metastasis can predict worse prognoses and significantly decreased survival. Lymph node size alone has been shown to be insufficient as a predictor for the accurate clinical staging of some canine neoplasia. However, certain regional lymph nodes (including those of the oral cavity) are difficult to access for routine tissue sampling. Read More

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http://dx.doi.org/10.1111/vru.12694DOI Listing

Results of a randomized controlled trial of level IIb preserving neck dissection in clinically node-negative squamous carcinoma of the oral cavity.

World J Surg Oncol 2018 Nov 8;16(1):219. Epub 2018 Nov 8.

Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005, India.

Background: The lymphatic spread from the cancers of the oral cavity follows an orderly progression and involvement of lower nodes without involvement of upper nodes and skip metastasis is rare. Selective neck dissections are increasingly being performed for node-positive patients; however, in node-negative patients the options of wait and watch, prophylactic radiotherapy, and prophylactic elective node dissections are debated. Quality of life and shoulder functions are important to choose the appropriate therapeutic modality. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-018-1
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http://dx.doi.org/10.1186/s12957-018-1518-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225726PMC
November 2018
15 Reads

[A Case of Long-Term Survival with Multidisciplinary Treatment in Unresectable Advanced Gastric Cancer Found with Ovarian Tumor].

Gan To Kagaku Ryoho 2018 Oct;45(10):1489-1491

Dept. of Surgery, Yokohama City University.

Although chemotherapy is the standard treatment for unresectable advanced gastric cancer, its prognosis is poor and the median survival time is only around 10 months. With some literature consideration, we report that ovarian metastasis triggered the diagnosis of unresectable advanced gastric cancer with long-term survival through multidisciplinary treatment. This is the case of a 69-year-old woman, who was diagnosed with ovarian tumor and underwent right extracorporectomy and omentum resection in 2011. Read More

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October 2018
3 Reads

Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.

Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39

Institut Universitaire du Cancer Toulouse - Oncopole, 1 avenue Irène Joliot-Curie, 31059, TOULOUSE Cedex 9, France.

Targeted therapies and immunotherapies are associated with a wide range of dermatologic adverse events (dAEs) resulting from common signaling pathways involved in malignant behavior and normal homeostatic functions of the epidermis and dermis. Dermatologic toxicities include damage to the skin, oral mucosa, hair, and nails. Acneiform rash is the most common dAE, observed in 25-85% of patients treated by epidermal growth factor receptor and mitogen-activated protein kinase kinase inhibitors. Read More

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http://link.springer.com/10.1007/s40257-018-0384-3
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http://dx.doi.org/10.1007/s40257-018-0384-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244569PMC
November 2018
16 Reads

Unique Photochemo-Immuno-Nanoplatform against Orthotopic Xenograft Oral Cancer and Metastatic Syngeneic Breast Cancer.

Nano Lett 2018 11 26;18(11):7092-7103. Epub 2018 Oct 26.

Department of Biochemistry and Molecular Medicine, UC Davis NCI-designated Comprehensive Cancer Center , University of California Davis , Sacramento , California 95817 , United States.

Sophisticated self-assembly may endow materials with a variety of unique functions that are highly desirable for therapeutic nanoplatform. Herein, we report the coassembly of two structurally defined telodendrimers, each comprised of hydrophilic linear PEG and hydrophobic cholic acid cluster as a basic amphiphilic molecular subunit. One telodendrimer has four added indocyanine green derivatives, leading to excellent photothermal properties; the other telodendrimer has four sulfhydryl groups designed for efficient intersubunit cross-linking, contributing to superior stability during circulation. Read More

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http://pubs.acs.org/doi/10.1021/acs.nanolett.8b03096
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http://dx.doi.org/10.1021/acs.nanolett.8b03096DOI Listing
November 2018
18 Reads

Squamous Cell Carcinoma of Maxillary Gingiva Progressing to Disseminated Carcinomatosis of Bone Marrow.

Bull Tokyo Dent Coll 2018 Nov 18;59(4):291-297. Epub 2018 Oct 18.

Department of Oral Medicine, Oral and Maxillofacial Surgery, Tokyo Dental College.

Disseminated carcinomatosis of the bone marrow (DCBM) is characterized by diffuse metastasis to bone marrow and sudden mortality. To the best of our knowledge, no studies to date have reported progression of oral squamous cell carcinoma to DCBM. Herein, we report a case of squamous cell carcinoma in the maxillary gingiva suspected of progressing to DCBM. Read More

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https://www.jstage.jst.go.jp/article/tdcpublication/advpub/0
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http://dx.doi.org/10.2209/tdcpublication.2018-0003DOI Listing
November 2018
26 Reads

Pretreatment quantitative F-FDG PET/CT parameters as a predictor of survival in adenoid cystic carcinoma of the salivary glands.

Clin Imaging 2019 Jan - Feb;53:17-24. Epub 2018 Oct 4.

Department of Radiology, University of Minnesota Medical Center, Minneapolis, MN 55455, USA. Electronic address:

Purpose: The aim of this study was to determine the unique prognostic value of quantitative F-FDG PET/CT parameters to assess progression-free survival (PFS), distant metastasis-free survival (DMFS), and overall survival (OS) in patients with salivary gland adenoid cystic carcinoma (ACC).

Methods: We performed a retrospective study including 23 patients (15 men, 8 women; median age, 58 years; range, 21-91 years) with salivary gland ACC between January 2009 and October 2017 who underwent F-FDG PET/CT scan prior to treatment. Maximum, mean, peak, tumor-to-mediastinal blood pool and tumor-to-liver standardized uptake values (SUV, SUV, SUV, SUV and SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were obtained from F-FDG PET/CT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08997071183026
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http://dx.doi.org/10.1016/j.clinimag.2018.09.021DOI Listing
March 2019
1 Read

Underexpression of α-1-microglobulin/bikunin precursor predicts a poor prognosis in oral squamous cell carcinoma.

Int J Oncol 2018 Dec 1;53(6):2605-2614. Epub 2018 Oct 1.

Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute, Tokyo 104-0045, Japan.

In the present study, in order to identify novel diagnostic biomarkers for the malignant behavior of oral squamous cell carcinoma (OSCC), we determined the proteomic profiles of several OSCC cell lines and keratinocytes by two-dimensional fluorescence difference gel electrophoresis and liquid chromatography tandem mass spectrometry. The protein expression level of α-1-microglobulin/bikunin precursor (AMBP) was found to be significantly lower in the OSCC cell lines than in the keratinocytes, and a significant decrease in AMBP mRNA expression was confirmed in the OSCC cell lines by RT-qPCR. To investigate the biological function of AMBP in OSCC, the cells were transiently transfected with an AMBP overexpression vector; the AMBP-overexpressing cells exhibited a significantly decreased invasion and migration in comparison to the mock-transfected control cells, although no significant changes in cell proliferation were observed. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2018.4581
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http://dx.doi.org/10.3892/ijo.2018.4581DOI Listing
December 2018
5 Reads

HLA-G Expression is Associated with an Unfavorable Prognosis of Oral Squamous Cell Carcinoma

Asian Pac J Cancer Prev 2018 Sep 26;19(9):2527-2533. Epub 2018 Sep 26.

Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Email:

Background: HLA-G, a major histocompatibility complex of non-classical class Ib, plays a key role in the development of the primary tumors to metastatic stages. The aim of this study was to investigate HLA-G expression in oral squamous cell carcinomas and its relationship with clinicopathological factors. Methods: After immunohistochemical staining for HLA-G with 63 formalin fixed and paraffin embedded blocks (33 oral squamous cell carcinoma and 30 normal oral mucosa samples), staining intensity, percentage of stained cells and final immunoreactivity score were evaluated, along with other variables. Read More

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http://dx.doi.org/10.22034/APJCP.2018.19.9.2527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249475PMC
September 2018
3 Reads
1.500 Impact Factor

Impact of enhanced recovery after surgery (ERAS) protocol on gastrointestinal function in gynecologic oncology patients undergoing laparotomy.

Gynecol Oncol 2018 11 21;151(2):282-286. Epub 2018 Sep 21.

Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL, United States.

Objective: To evaluate the impact of enhanced recovery after surgery (ERAS) on postoperative gastrointestinal function in gynecologic oncology patients.

Methods: This retrospective cohort study compared gynecology oncology patients undergoing non-emergent laparotomy from 10/2016 to 6/2017 managed on an ERAS protocol to a control cohort from the year prior to ERAS implementation. Major changes to postoperative care after ERAS implementation included multimodal analgesia, early feeding, goal-directed fluid resuscitation, and early ambulation. Read More

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http://dx.doi.org/10.1016/j.ygyno.2018.09.009DOI Listing
November 2018
5 Reads

Preoperative diagnostic of parotid gland neoplasms: fine-needle aspiration cytology or core needle biopsy?

Eur Arch Otorhinolaryngol 2018 Nov 20;275(11):2609-2613. Epub 2018 Sep 20.

International Head and Neck Scientific Group, Padua, Italy.

A preoperative cytologic or histologic diagnosis of parotid gland neoplasms is mandatory to decide which surgical procedure would be appropriate. Open biopsies are contraindicated because of the risk of recurrence secondary to tumour cell seeding; furthermore a subsequent curative parotid surgery can be complicated by a previous open biopsy. While fine-needle aspiration cytology (FNAC) was the only preoperative diagnostic procedure to distinguish benign versus malignant neoplasms over the past decades, core needle biopsy (CNB) has been increasingly used over the last few years. Read More

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http://dx.doi.org/10.1007/s00405-018-5131-0DOI Listing
November 2018
2 Reads

Targeted next-generation sequencing of 50 cancer-related genes in Japanese patients with oral squamous cell carcinoma.

Tumour Biol 2018 Sep;40(9):1010428318800180

1 Department of Medical Genome Sciences, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo, Japan.

Somatic mutation analysis is a standard of practice for human cancers to identify therapeutic sensitization and resistance mutations. We performed a multigene sequencing screen to explore mutational hotspots in cancer-related genes using a semiconductor-based sequencer. DNA from oral squamous cell carcinoma samples was used as a template to amplify 207 regions from 50 cancer-related genes. Read More

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http://dx.doi.org/10.1177/1010428318800180DOI Listing
September 2018
11 Reads

[Clinicopathologic features and prognosis of adenoid cystic carcinoma of external auditory meatus].

Zhonghua Bing Li Xue Za Zhi 2018 Sep;47(9):691-695

Department of Pathology, PLA General Hospotal, Beijing 100853, China.

To investigate clinicopathologic features and prognosis of adenoid cystic carcinoma (ACC) involving external auditory meatus. The clinical presentation and follow-up data of 63 patients with ACC of external auditory canal were collected from January 2006 to February 2017 at PLA General Hospital and Hainan Branch of PLA General Hospital. The clinicopathologic features and prognostic factors of external auditory canal ACC were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.09.008DOI Listing
September 2018
2 Reads

Immunohistochemical expression of TWIST in oral squamous cell carcinoma and its correlation with clinicopathologic factors.

J Cancer Res Ther 2018 Jul-Sep;14(5):964-969

Students Research Committee, Babol University of Medical Sciences, Babol University of Medical Sciences, Babol, IR Iran.

Background And Objectives: TWIST is a transcription factor that plays a key role in the development of primary tumor to metastatic stage of cancer. It is an inhibitor of E-cadherin in epithelial-to-mesenchymal transformation process (epithelial-mesenchymal transition). Few studies are available on the use of TWIST as a goal in molecular-targeted therapy. Read More

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http://dx.doi.org/10.4103/0973-1482.224350DOI Listing
November 2018
3 Reads

Maxillary reconstruction using rectus femoris muscle flap and sagittal mandibular ramus/coronoid process graft pedicled with temporalis muscle.

Med Oral Patol Oral Cir Bucal 2018 Sep 1;23(5):e619-e624. Epub 2018 Sep 1.

No. 1088 Mid Hai Yuan Road Gaoxin District, Kunming Yunnan 650106, China,

Background: Maxillary reconstruction using various pedicled and free-tissue transfer techniques with bone graft or without bone graft has some drawbacks. In this study, we demonstrate maxillary reconstruction using femoris rectus muscle flap and sagittal mandibular ramus/coronoid process graft pedicled with temporalis muscle through the modified lateral lip-submandibular approach.

Material And Methods: Nine patients suffering from maxillary defects secondary to maxillary cancer ablation, who underwent maxillary reconstruction using rectus femoris muscle flap and sagittal mandibular ramus/coronoid process graft pedicled with temporalis muscle, were enrolled into this study between November 2015 and August 2017. Read More

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http://dx.doi.org/10.4317/medoral.22505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167095PMC
September 2018
20 Reads

Prognostic factors in parotid cancers: Clinicopathological and treatment factors influencing outcomes.

Indian J Cancer 2018 Jan-Mar;55(1):98-104

Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Background: Parotid cancers are uncommon and have a relatively long natural history. Determination of prognostic factors affecting the outcome is difficult.

Materials And Methods: The primary objective was to determine the demographic, clinical, histopathology and treatment-related factors affecting overall survival (OS) in parotid cancers. Read More

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http://dx.doi.org/10.4103/ijc.IJC_503_17DOI Listing
November 2018
16 Reads

Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma.

Oncol Rep 2018 Nov 22;40(5):2487-2496. Epub 2018 Aug 22.

Division of Oral Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951‑8514, Japan.

Transcription factor SRY‑box 9 (SOX9) is a key regulator of chondrocyte differentiation and sex determination, and it is also involved in the progression of various types of human cancer. However, its putative association with oral squamous cell carcinoma (OSCC) remains elusive. The aim of the present study was to investigate the expression profiles of SOX9 in various oral epithelial lesions, including OSCC. Read More

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http://dx.doi.org/10.3892/or.2018.6665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151877PMC
November 2018
18 Reads

Determination of the origin of oral squamous cell carcinoma by microarray analysis: Squamous epithelium or minor salivary gland?

Int J Cancer 2018 11 21;143(10):2551-2560. Epub 2018 Sep 21.

Department of Oral and Maxillofacial Surgery, Dokkyo Medical University School of Medicine, Tochigi, Japan.

More than 90% of oral cancers are histopathologically squamous cell carcinomas (SCCs). According to clinical behavior and histopathological features, we hypothesize that oral SCC can originate from either oral squamous epithelium or minor salivary glands. Here, we examined whether some oral SCCs originate from minor salivary glands, and investigated whether these tumors show particularly aggressive biological behavior. Read More

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http://dx.doi.org/10.1002/ijc.31811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220885PMC
November 2018
7 Reads

Mediastinal metastasectomy from a primary germ cell testicular tumour resulting in occult thoracic duct injury and chylothorax.

BMJ Case Rep 2018 Aug 17;2018. Epub 2018 Aug 17.

Cardiothoracic Surgery, Fiona Stanley Hospital, Perth, Western Australia, Australia.

A 22-year-old man underwent mediastinal metastasectomy for a testicular germ cell tumour via median sternotomy. Intraoperatively, the tumour was massive, measuring 88 mm in anterior-posterior (AP) diameter. It was densely adherent to the trachea and aggressive debulking resulted in tracheal injury. Read More

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http://dx.doi.org/10.1136/bcr-2018-225715DOI Listing
August 2018
14 Reads

Participation of hypoxia-inducible factor-1α and lymphangiogenesis in metastatic and non-metastatic lower lip squamous cell carcinoma.

J Craniomaxillofac Surg 2018 Oct 29;46(10):1741-1747. Epub 2018 Jul 29.

Postgraduation Program in Oral Pathology, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil. Electronic address:

This study evaluated the lymphatic density and HIF-1α immunoexpression in lower lip squamous cell carcinoma (LLSCC) and their correlation with clinicopathological (nodal metastasis, clinical stage, histological grade, recurrence and disease outcome) and survival parameters in 20 metastatic and 20 non-metastatic LLSCCs. Lymphatic density was established by counting microvessels (D2-40) at the tumor core (intratumoral lymphatic density, ILD) and at the invasive front (peritumoral lymphatic density, PLD) and percentages of immunopositive cells for HIF-1α were established. No statistically significant differences in lymphatic densities in relation to clinicopathological parameters were observed (P > 0. Read More

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http://dx.doi.org/10.1016/j.jcms.2018.07.020DOI Listing
October 2018
3 Reads

Clinical and genetic signatures of local recurrence in oral squamous cell carcinoma.

Arch Oral Biol 2018 Nov 6;95:141-148. Epub 2018 Aug 6.

The Maxillo-Facial Surgery Department, Baruch Padeh Medical Center, The Faculty of Medicine, Bar Ilan University, Galilee, Israel.

Purpose: Recurrent and metastatic Oral Squamous Cell Carcinoma (OSCC) is often incurable. There are large gaps in the understanding of the clinical course, biology and genetic biomarkers of OSCC which could help us identify patients with high-risk of recurrence who may benefit from intensified therapy or novel targeted therapy trials. The purpose of this study was to identify significant clinical, pathological and genomic risk factors for local recurrence in OSCC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039969183043
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http://dx.doi.org/10.1016/j.archoralbio.2018.07.018DOI Listing
November 2018
22 Reads

Efficacy and safety of nimotuzumab in unresectable, recurrent, and/or metastatic squamous cell carcinoma of the head and neck: A hospital-based retrospective evidence.

South Asian J Cancer 2018 Jul-Sep;7(3):188-192

Medical affairs, Biocon Ltd, Bengaluru, Karnataka, India.

Context: Role of nimotuzumab in locally advanced head and neck cancer (HNC) is well established in India; however, no clinical evidence is available for its role in recurrent and/or metastatic HNC.

Aims: The aim of this study is to evaluate the efficacy and safety of nimotuzumab when added to standard treatment in unresectable, recurrent, and metastatic squamous cell carcinoma of the head and neck (SCCHN).

Settings And Design: Hospital records of 14 patients diagnosed with recurrent and/or metastatic HNC with histologically confirmed squamous cell carcinoma and being treated with nimotuzumab along with standard treatments from December 2010 to December 2016 were retrospectively evaluated. Read More

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http://dx.doi.org/10.4103/sajc.sajc_87_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069342PMC
August 2018
2 Reads

Preventive measures in oral cancer: An overview.

Biomed Pharmacother 2018 Nov 3;107:72-80. Epub 2018 Aug 3.

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, India. Electronic address:

Worldwide oral cancer is creating an alarming situation and it's a matter of global concern as it is the 11th most common carcinoma around the globe. After cardiovascular ailments, cancer is the next biggest killer. Approximately 90% of the total oral malignancies are squamous cell carcinomas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183363
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http://dx.doi.org/10.1016/j.biopha.2018.07.114DOI Listing
November 2018
25 Reads

Chemosensitizing effect of honokiol in oral carcinoma stem cells via regulation of IL-6/Stat3 signaling.

Environ Toxicol 2018 Nov 4;33(11):1105-1112. Epub 2018 Aug 4.

School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.

Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide with poor prognosis. Numerous studies have attempted to explore alternative regimens aimed at reducing cancer stem cells (CSCs) without compromising the efficacy of conventional chemoradiotherapy. The present study sought to assess the effect of a natural compound honokiol on the reduction of elevated cancer stemness, metastatic capacity, and chemoresistance of oral carcinoma stem cells (OCSCs). Read More

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http://dx.doi.org/10.1002/tox.22587DOI Listing
November 2018
2 Reads

Rare breast metastasis from adenoid cystic carcinoma of the submandibular gland.

BMJ Case Rep 2018 Aug 1;2018. Epub 2018 Aug 1.

Department of Surgery, Duke University Hospital, Durham, North Carolina, USA.

Adenoid cystic carcinomas (ACCs) are rare malignant neoplasms of exocrine glands, most commonly found in salivary glands. This report describes a 67-year-old woman with metastatic ACC to the breast, only the third reported case of its kind. The salivary gland ACC was first diagnosed 5 years prior. Read More

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http://dx.doi.org/10.1136/bcr-2017-223345DOI Listing
August 2018
4 Reads

Elective Neck Dissection for Management of Early- Stage Oral Tongue Cancer

Asian Pac J Cancer Prev 2018 Jul 27;19(7):1797-1803. Epub 2018 Jul 27.

Department of Surgical Oncology, National Cancer Institute, Cairo University, Egypt. Email:

Background: The occult neck metastasis rate is very high with tongue cancers. The aim of this study was to assess the current role of elective neck dissection (END) in management of early-stage oral tongue cancer with a focus on lymph node metastasis. In addition, effects of END on regional or systemic disease recurrence and survival were investigated. Read More

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http://dx.doi.org/10.22034/APJCP.2018.19.7.1797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165647PMC
July 2018
3 Reads

Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer.

Genome Med 2018 07 20;10(1):54. Epub 2018 Jul 20.

Department of Molecular and Cell Biology, Goldman School of Dental Medicine, Boston University School of Medicine, 72 East Concord Street, E4, Boston, MA, 02118, USA.

Background: Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy characterized by tumor heterogeneity, locoregional metastases, and resistance to existing treatments. Although a number of genomic and molecular alterations associated with HNSCC have been identified, they have had limited impact on the clinical management of this disease. To date, few targeted therapies are available for HNSCC, and only a small fraction of patients have benefited from these treatments. Read More

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http://dx.doi.org/10.1186/s13073-018-0569-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053793PMC
July 2018
47 Reads
4.942 Impact Factor

Functional considerations in oral cavity reconstruction.

Curr Opin Otolaryngol Head Neck Surg 2018 Oct;26(5):326-333

Massachusetts Eye and Ear Infirmary, Harvard School of Medicine, Boston, Massachusetts, USA.

Purpose Of Review: The treatment of oral cavity cancer may impair speech and swallowing function. Optimizing posttreatment function may lead to significant improvement of quality of life.

Recent Findings: Although oncologic control remains the main goal of treatment for oral cavity cancer, posttreatment function for surviving patients has over the last decades been recognized as an important secondary outcome. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000474DOI Listing
October 2018
24 Reads

Notch signalling induces epithelial‑mesenchymal transition to promote metastasis in oral squamous cell carcinoma.

Int J Mol Med 2018 Oct 12;42(4):2276-2284. Epub 2018 Jul 12.

School of Clinical Medicine, Hainan Medical University, Haikou, Hainan 571199, P.R. China.

The activation of Notch signalling induces epithelial‑mesenchymal transition (EMT), but this signalling pathway and its association with EMT in the context of cell motility in oral squamous cell carcinoma (OSCC) remains unclear. The present study aimed to investigate the role of the Notch signalling pathway and EMT in the metastatic potential of OSCC using 2 cell lines, Tca8113 and CAL27. The data demonstrated that zinc finger domain SNAI1 (Snail) knockdown by small interfering RNA decreased the expression of vimentin and increased the expression of epithelial cadherin (E‑cadherin). Read More

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http://dx.doi.org/10.3892/ijmm.2018.3769DOI Listing
October 2018
2 Reads

Metastasizing pleomorphic adenoma of parotid presenting as a huge renal mass.

Indian J Pathol Microbiol 2018 Jul-Sep;61(3):456-457

Department of Genitourinary Surgery, Government Medical College, Kottayam, Kerala, India.

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http://dx.doi.org/10.4103/IJPM.IJPM_111_17DOI Listing
January 2019
3 Reads