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    4528 results match your criteria Metastatic Neoplasms to the Oral Cavity

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    A Case of Hepatocellular Carcinoma Presenting as a Gingival Mass.
    Korean J Gastroenterol 2016 Dec;68(6):321-325
    Department of Pathology, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
    Oral metastatic tumor, which is uncommon and represents less than 1% of malignant oral neoplasms, usually arises from a primary mucosal or cutaneous cancer located in the head and neck regions. Metastasis of hepatocellular carcinoma (HCC) to the oral cavity, especially to gingiva, is extremely rare. A 50-year-old man, who was a chronic alcoholic and hepatitis B virus carrier, presented with abdominal distension and weight loss for the past 3 months. Read More

    Tumorigenicity and Validity of Fluorescence Labelled Mesenchymal and Epithelial Human Oral Cancer Cell Lines in Nude Mice.
    Biomed Res Int 2016 13;2016:4897986. Epub 2016 Nov 13.
    Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kong.
    Tumorigenicity and metastatic activity can be visually monitored in cancer cells that were labelled with stable fluorescence. The aim was to establish and validate local and distant spread of subcutaneously previously injected fluorescence transduced human tongue cancer cell lines of epithelial and mesenchymal phenotype in nude mice. A total of 32 four-week-old male athymic Balb/c nude mice were randomly allocated into 4 groups (n = 8). Read More

    Management of neck metastases in head and neck cancer: United Kingdom National Multidisciplinary Guidelines.
    J Laryngol Otol 2016 May;130(S2):S161-S169
    Department of Clinical Oncology,St James's Institute of Oncology,Leeds,UK.
    This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. A rational plan to manage the neck is necessary for all head and neck primaries. With the emergence of new level 1 evidence across several domains of neck metastases, this guideline will identify the evidence-based recommendations for management. Read More

    Investigation and management of the unknown primary with metastatic neck disease: United Kingdom National Multidisciplinary Guidelines.
    J Laryngol Otol 2016 May;130(S2):S170-S175
    Department of Otolaryngology - Head and Neck Surgery,Guy's and St Thomas' Hospital NHS Foundation Trust,Department of Otolaryngology - Head and Neck Surgery,Guy's, King's and St Thomas' Medical and Dental School,London,UK.
    This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. It discusses the evidence base pertaining to the management of metastatic neck disease in the setting of an unknown primary and provides recommendations on the work up and management for this group of patients receiving cancer care. Recommendations • All patients presenting with confirmed cervical lymph node metastatic squamous cell carcinoma and no apparent primary site should undergo: ○ Positron emission tomography-computed tomography whole-body scan. Read More

    [Simultaneous repairing defects of orbital floor and palate with the modified temporalis muscle flap after the maxillectomy].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2016 Sep;51(9):671-674
    Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University; Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing 100710, China.
    Objective: To evaluate the outcome of one-stage reconstruction of maxillary and orbital defects with modified temporalis muscle flap (TMF) following the removal of malignant neoplasms. Methods: In this retrospective study, 15 patients underwent the reconstruction of defects of orbital floor and palate after maxillectomy for malignant tumor were included from June 2008 to June 2014. The modified temporalis muscle flap was used to repair the defects after surgery, and functional outcomes were analyzed. Read More

    Additional non-sentinel lymph node metastases in early oral cancer patients with positive sentinel lymph nodes.
    Eur Arch Otorhinolaryngol 2017 Feb 25;274(2):961-968. Epub 2016 Aug 25.
    Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands.
    To determine risk factors for additional non-sentinel lymph node metastases in neck dissection specimens of patients with early stage oral cancer and a positive sentinel lymph node biopsy (SLNB). A retrospective analysis of 36 previously untreated SLNB positive patients in our institution and investigation of currently available literature of positive SLNB patients in early stage oral cancer was done. Degree of metastatic involvement [classified as isolated tumor cells (ITC), micro- and macrometastasis] of the sentinel lymph node (SLN), the status of other SLNs, and additional non-SLN metastases in neck dissection specimens were analyzed. Read More

    Significant symptoms alleviation and tumor volume reduction after combined simultaneously integrated inner-escalated boost and volumetric-modulated arc radiotherapy in a patient with unresectable bulky hepatocellular carcinoma: A care-compliant case report.
    Medicine (Baltimore) 2016 Aug;95(34):e4717
    aDepartment of Radiation Oncology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation bDepartment of Radiation Oncology, Buddhist Tzu Chi General Hospital cSchool of Medicine, Tzu Chi University, Hualien dDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei eDepartment of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung fInstitute of Molecular Biology, Department of Life Science gHuman Epigenomics Center hNational Chung Cheng University, Min-Hsiung, Chia-Yi, Taiwan, ROC.
    Background: Clinically, elderly patients with unresectable bulky hepatocellular carcinoma (HCC) are difficult to manage, especially in those with co-infections of hepatitis B and C virus. Herein, we reported such a case treated with radiotherapy (RT) by using combined simultaneously integrated inner-escalated boost and volumetric-modulated arc radiotherapy (SIEB-VMAT). After RT, significant symptoms alleviation and durable tumor control were observed. Read More

    Role of neck dissection in metastatic squamous cell carcinoma to the parotid gland.
    J Laryngol Otol 2016 Jul;130 Suppl 4:S54-9
    Department of Otolaryngology Head and Neck Surgery,Royal North Shore Hospital,Sydney,Australia.
    Objective: To investigate the rate of occult neck disease in patients with metastatic squamous cell carcinoma to the parotid gland following parotidectomy and neck dissection.

    Methods: A consecutive series of patients treated between 2000 and 2014 for metastatic squamous cell carcinoma to the parotid were analysed. Patients were included if they had no clinical or radiological evidence of neck disease. Read More

    [Anesthetic Management of Cesarean Section in a Pregnant Woman with Advanced Tongue Cancer].
    Masui 2016 Jun;65(6):632-5
    It is very difficult to decide the best time to deliver the baby for a pregnant woman with advanced cancer. We experienced the perioperative and perinatal management of a 39-year-old pregnant woman with advanced tongue cancer. The cancer had already metastasized to the lung and lymph nodes. Read More

    Oral pathogens change proliferation properties of oral tumor cells by affecting gene expression of human defensins.
    Tumour Biol 2016 Oct 1;37(10):13789-13798. Epub 2016 Aug 1.
    Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Welschnonnenstr. 17, 53111, Bonn, Germany.
    The impact of oral pathogens onto the generation and variability of oral tumors has only recently been investigated. To get further insights, oral cancer cells were treated with pathogens and additionally, as a result of this bacterial cellular infection, with human defensins, which are as anti-microbial peptide members of the innate immune system. After cell stimulation, proliferation behavior, expression analysis of oncogenic relevant defensin genes, and effects on EGFR signaling were investigated. Read More

    Interventions for treating oral leukoplakia to prevent oral cancer.
    Cochrane Database Syst Rev 2016 Jul 29;7:CD001829. Epub 2016 Jul 29.
    Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Via Beldiletto 1/3, Milan, Italy, 20142.
    Background: Oral leukoplakia is a relatively common oral lesion that, in a small proportion of people, precedes the development of oral cancer. Most leukoplakias are asymptomatic; therefore, the primary objective of treatment should be to prevent onset of cancer. This review updates our previous review, published in 2006. Read More

    Plasmablastic lymphoma exclusively involving bones mimicking osteosarcoma in an immunocompetent patient: A case report.
    Medicine (Baltimore) 2016 Jul;95(28):e4241
    aDepartment of Nuclear Medicine bFellowship of Koh Chang Soon Program, Seoul National University College of Medicine, Seoul, Korea cNational Institute of Nuclear Medicine and Allied Sciences, BAEC, BSMMU campus, Dhaka, Bangladesh dDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University eCancer Research Institute, College of Medicine, Seoul National University, Seoul, Korea.
    Background: It has been known that plasmablastic lymphoma (PBL) is a neoplasm of immunocompromised patients occurring in soft tissue of oral cavity or in the vicinity whereas bone is an unlikely site to harbor PBL. However, its occurrence is increasingly being reported in immunocompetent individuals in either osseous or extra-oral sites. To our best knowledge, F-18 FDG PET/CT findings of PBL involving bones in an immunocompetent patient have not been reported, yet . Read More

    Risk estimation of second primary cancers after breast radiotherapy.
    Acta Oncol 2016 Nov 5;55(11):1331-1337. Epub 2016 Jul 5.
    a School of Physical Sciences, University of Adelaide , Adelaide , South Australia , Australia.
    Aims: There is evidence towards the induction of second primary cancers (SPCs) after breast radiotherapy (RT). Organs, such as the lungs and the esophagus, have been identified as common sites for SPC formation. As a result, the current study investigated the risk of secondary carcinogenesis associated with particular RT techniques for breast cancer; including whole breast, segmented breast, partial breast and mammosite brachytherapy. Read More

    Analysis of rare periparotid recurrence after parotid gland-sparing intensity-modulated radiotherapy for nasopharyngeal carcinoma.
    Cancer Radiother 2016 Jul 29;20(5):377-83. Epub 2016 Jun 29.
    The Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China; Department of Radiation Oncology, Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou, Fujian, People's Republic of China; Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian, People's Republic of China. Electronic address:
    Purpose: Periparotid recurrence is an uncommon phenomenon after intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma. This study aimed to discuss the clinical characteristics, reasonable causes and feasible therapeutic modalities of patients with nasopharyngeal carcinoma and periparotid recurrence.

    Patients And Methods: The medical records of 1852 patients with non-metastatic nasopharyngeal carcinoma treated with initial IMRT between January 2008 and December 2012 were retrospectively reviewed, and nine patients were finally found to have developed periparotid recurrence after IMRT. Read More

    High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma.
    Eur Arch Otorhinolaryngol 2016 Dec 21;273(12):4515-4524. Epub 2016 Jun 21.
    Transplantation Laboratory, Haartman Institute, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014, Helsinki, Finland.
    Tongue cancer has a poor prognosis due to its early metastasis via lymphatic vessels. The present study aimed at evaluating lymphatic vessel density, relative density of lymphatic vessel, and diameter of lymphatic vessels and its predictive role in tongue cancer. Paraffin-embedded tongue and lymph node specimens (n = 113) were stained immunohistochemically with a polyclonal antibody von Willebrand factor, recognizing blood and lymphatic endothelium and with a monoclonal antibody podoplanin, recognizing lymphatic endothelium. Read More

    Pre-surgical assessment of mandibular bone invasion from oral cancer: comparison between different imaging techniques and relevance of radiologist expertise.
    Radiol Med 2016 Sep 4;121(9):704-10. Epub 2016 Jun 4.
    Sezione di Radiologia, Dipartimento di Scienze Chirurgiche, Università degli Studi di Parma, Parma, Italy.
    Purpose: To compare diagnostic performance between computed tomography (CT) and magnetic resonance imaging (MRI) for the detection of bone infiltration from oral cancer, and to test interobserver agreement between radiologists with different expertises.

    Materials And Methods: Pre-surgical CT and MRI were reviewed independently by two radiologists with different expertises in head and neck oncology. A third radiologist reviewed CT and MRI simultaneously. Read More

    [MRI interstitial (125)I seed implantation treatment for oral and maxillofacial adenogenic malignant tumor].
    Zhonghua Kou Qiang Yi Xue Za Zhi 2016 Jun;51(6):346-9
    Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
    Objective: To assess the therapeutic efficacy of MRI guided interstitial (125)I seed implantation in the treatment of oral and maxillofacial adenogenic malignant tumor Methods: A total of 39 patients with oral and maxillofacial adenogenic malignant tumors received interstitial (125)I implantation treatment one week postoperatively. Before implantation, MRI scanning was performed and implantation plan of (125)I was designed with the aid of treating plan system. During the implantation, positioning pin was firstly implanted and then its position and direction were adjusted according to navigation. Read More

    [Perception of adverse reactions of chemotherapy and hormone therapy by women treated for breast cancer].
    Therapie 2016 Jun 15;71(3):263-73. Epub 2016 Feb 15.
    Pôle innovation-santé, service universitaire de médecine générale, faculté de médecine Jacques-Lisfranc, université Jean-Monnet, campus Santé Innovations, 10, rue de la Marandière, 42270 Saint-Priest-en-Jarez, France. Electronic address:
    Introduction: In Europe, breast cancer is the most common cancer among women. His treatment (TTT) can have a significant impact on daily life.

    Aims: Explore the experienced short-term side effects (SE) of chemotherapy and hormonal therapy by women themselves, the information delivered and the place of the general practitioner (GP). Read More

    Association of Notch4 with metastasis in human oral squamous cell carcinoma.
    Life Sci 2016 Jul 16;156:38-46. Epub 2016 May 16.
    Department of Genetic Engineering, School of Bioengineering, SRM University, Kattankulathur 603203, India. Electronic address:
    Aims: Despite the development of several therapeutic strategies in the past decades, clinicians have failed to improve the survival rate of oral squamous cell carcinoma patients due to the highly metastatic nature of the disease and its high recurrence rate. However, there is accumulating evidence that aberrant Notch4 expression has a critical role in tumorigenesis but its prognostic value and function in OSCC remains uncertain. This study therefore investigates (1) the expression of Notch4 and its downstream target, myelin associated glycoprotein (MAG) in tissue samples representative of different stages of OSCC with varied clinicopathological features and (2) the possible involvement of Notch4 in the proliferation and migration of OSCC cells. Read More

    Renal clear cell carcinoma metastasis to salivary glands - a series of 9 cases: clinico-pathological study.
    Pol J Pathol 2016 Mar;67(1):39-45
    Hanna Majewska MD, PhD, Department of Pathology, Medical University of Gdansk, Dębinki 7, 80-211 Gdansk, Poland, tel. +48 601 762 460, fax +48 58 349 37 45, e-mail:
    Metastatic tumors involving salivary glands arising from the non-head and neck area are very rare. Renal cell carcinoma (RCC) is known for its high propensity for metastasis to unusual localizations. RCC metastasis to the maxillofacial area is an uncommon event (16%), but metastasis to salivary glands is extremely rare. Read More

    A genome-wide association study of non-HPV-related head and neck squamous cell carcinoma identifies prognostic genetic sequence variants in the MAP-kinase and hormone pathways.
    Cancer Epidemiol 2016 06 9;42:173-80. Epub 2016 May 9.
    Ontario Cancer Institute and Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada,; Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. Electronic address:
    Background: Carcinomas of the oral cavity, pharynx and larynx are referred to as head and neck cancers (HNC); together they account for 2-3% of all newly diagnosed cancers in North America. Between 40-50% of HNC are early diagnosed at stages I-II. The 5-year and 10-year relative survival rates are 61% and 50%, respectively. Read More

    Oral malignant melanoma: An aggressive clinical entity - Report of a rare case with review of literature.
    J Int Soc Prev Community Dent 2016 Mar-Apr;6(2):176-81
    Department of Conservative Dentistry and Endodontics, Specialist Dental Center, Hafer Al Batin, Saudi Arabia.
    Melanomais one of the most dreaded and aggressive neoplasms, being derived from epidermal melanocytes. The majority of melanomas are seen to involve the skin, and primary mucosal melanomas account for less than 1% of all melanomas. Oral malignant melanomas (OMM) are asymptomatic at the initial presentation, but later they become painful with growth and expansion. Read More

    Combination chemotherapy of carboplatin and paclitaxel for advanced/metastatic salivary gland carcinoma patients: differences in responses by different pathological diagnoses.
    Acta Otolaryngol 2016 Sep 20;136(9):948-51. Epub 2016 Apr 20.
    a Department of Medical Oncology , Cancer Institute Hospital of the Japanese Foundation for Cancer Research , Tokyo , Japan ;
    Background: A standard chemotherapy for recurrent/metastatic salivary gland cancers has not been established. Combination chemotherapy of carboplatin and paclitaxel should be evaluated as a treatment option.

    Methods: This study retrospectively reviewed salivary gland cancer patients who received combination chemotherapy of carboplatin and paclitaxel. Read More

    Indications for Salivary Gland Radiotherapy.
    Adv Otorhinolaryngol 2016 12;78:141-7. Epub 2016 Apr 12.
    There is an established role for post-operative radiotherapy in the treatment of benign and malignant salivary gland tumours. For benign disease, the addition of radiotherapy improves local tumour control in cases with incomplete excision, involved surgical margins or multi-focal disease recurrence. After capsule rupture or spillage alone, surveillance should usually be advised. Read More

    Evaluation: Fine Needle Aspiration Cytology, Ultrasound-Guided Core Biopsy and Open Biopsy Techniques.
    Adv Otorhinolaryngol 2016 12;78:39-45. Epub 2016 Apr 12.
    The optimum technique for biopsy assessment of the nature of a major salivary gland mass remains controversial. Fine needle aspiration cytology (FNAC) has been the traditional and popular choice, but sampling of cellular clusters is largely associated with high non-diagnostic and false-negative rates, even under optimised circumstances. Ultrasound-guided core biopsy (USCB) provides a core of tissue that allows preservation of tissue architecture and that can be histologically and immunohistochemically examined, thereby improving the chances of a meaningful diagnosis. Read More

    Metastatic Cancer to the Parotid.
    Adv Otorhinolaryngol 2016 12;78:95-103. Epub 2016 Apr 12.
    In many regions of the world, the most common type of parotid malignancy is metastatic malignancy. Metastatic cutaneous squamous cell carcinoma and metastatic melanoma are the most common pathologies that metastasize to the parotid gland and cervical lymph nodes. Other more rare metastatic malignancies from cutaneous primary sites include Merkel cell carcinoma, pleomorphic sarcoma (previously called malignant fibrous histiocytoma) and metastatic basal cell carcinoma. Read More

    Sentinel Node in Oral Cancer: The Nuclear Medicine Aspects. A Survey from the Sentinel European Node Trial.
    Clin Nucl Med 2016 Jul;41(7):534-42
    From the *Department of Nuclear Medicine, Cristo Re Hospital, Rome, Italy; †Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital St Gallen, St Gallen, Switzerland; ‡Department of Head and Neck Surgical Oncology, UMCU Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands; §Department of Head and Neck Surgery, Guys and St Thomas NHS Trust, London, UK; ∥Department of Plastic and Reconstructive Surgery, Odense University Hospital, Odense, Denmark; ¶Department of Otolaryngology-Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen, Denmark; **Department of Head and Neck Surgery, CHU Dinant Godinne, Université Catholique de Louvain, Belgium; ††Department of Maxillofacial Surgery, CHU de Charleroi Belgium, Belgium; ‡‡Department of Maxillofacial Surgery, Hospital Universitario Central de Asturias, Oviedo, Spain; §§Department of Pathology, Hospital Universitario Central de Asturias, Oviedo, Spain; ∥∥Department of Maxillofacial Surgery, BioCruces, Hospital Universitario De Cruces, Universidad del Pais Vasco (UPV/EHU), Bilbao, Spain; ¶¶Department of Head and Neck Surgery, Instituto Portugues de Oncologia do Porto, Portugal; ***Department of Maxillofacial Surgery, Azienda Ospedaliera, Universitaria di Parma, Parma, Italy; †††Department of Otolaryngology, Ospedale S. Chiara, Trento, Italy; ‡‡‡Department of Otorhinolaryngology, San Carlo Hospital, Rome, Italy; §§§Department of Nuclear Medicine, Guys and St Thomas NHS Trust, London, UK; ∥∥∥Department of Nuclear Medicine, Ospedale S. Chiara, Trento, Italy; ¶¶¶Department of Pathology, VU University Medical Centre and Academic Centre of Dentistry Amsterdam, Amsterdam, The Netherlands; ****Pathology Centre, Queen Alexandra Hospital, Portsmouth, UK; ††††Department of Head and Neck Surgery, University of Basel, Basel, Switzerland; ‡‡‡‡Department of Otolaryngology, University Hospital Zurich, Zurich, Switzerland; §§§§Dep
    Purpose: Nuclear imaging plays a crucial role in lymphatic mapping of oral cancer. This evaluation represents a subanalysis of the original multicenter SENT trial data set, involving 434 patients with T1-T2, N0, and M0 oral squamous cell carcinoma. The impact of acquisition techniques, tracer injection timing relative to surgery, and causes of false-negative rate were assessed. Read More

    Leukemic Oral Manifestations and their Management.
    Asian Pac J Cancer Prev 2016 ;17(3):911-5
    Bauru School of Dentistry, University of Sao Paulo, Department of Biological Sciences, Bauru, SP, Brazil E-mail :
    Leukemia is the most common neoplastic disease of the white blood cells which is important as a pediatric malignancy. Oral manifestations occur frequently in leukemic patients and may present as initial evidence of the disease or its relapse. The symptoms include gingival enlargement and bleeding, oral ulceration, petechia, mucosal pallor, noma, trismus and oral infections. Read More

    Commonest Cancers in Pakistan - Findings and Histopathological Perspective from a Premier Surgical Pathology Center in Pakistan.
    Asian Pac J Cancer Prev 2016 ;17(3):1061-75
    Pathology and Laboratory Medicine, Histopathology, Aga Khan University Hospital, Karachi, Pakistan E-mail :
    Context: There are no recent authoritative data about incidence and prevalence of various types of cancers in Pakistan.

    Aim: To determine the frequency of malignant tumors seen in our practice and provide a foundation for building a comprehensive cancer care strategy.

    Materials And Methods: 10,000 successive cases of solid malignant tumors reported in 2014 were included. Read More

    Cathepsin B Expression and the Correlation with Clinical Aspects of Oral Squamous Cell Carcinoma.
    PLoS One 2016 31;11(3):e0152165. Epub 2016 Mar 31.
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
    Background: Cathepsin B (CTSB), a member of the cathepsin family, is a cysteine protease that is widely distributed in the lysosomes of cells in various tissues. It is overexpressed in several human cancers and may be related to tumorigenesis. The main purpose of this study was to analyze CTSB expression in oral squamous cell carcinoma (OSCC) and its correlation with patient prognosis. Read More

    Inhibitory Effects of AVEMAR on Proliferation and Metastasis of Oral Cancer Cells.
    Nutr Cancer 2016 23;68(3):473-80. Epub 2016 Mar 23.
    a Terry Fox Cancer Research Laboratory, China Medical University Hospital , Taichung , Taiwan, R.O.C.
    Oral cancer is keeping its 4th rank on the death causing cancers among Taiwan males, and its metastatic and recurrent rates remain high and a life-threatening issue to the citizens. Fermented wheat germ extract (AVEMAR) is used in clinical cancer nutritional therapy in gastrointestinal cancers but not in oral cancer yet. In this study, the potential of AVEMAR to inhibit tumor proliferation and metastasis of oral cancer was first investigated. Read More

    Mucosal malignant melanoma - a clinical, oncological, pathological and genetic survey.
    APMIS 2016 Jun 22;124(6):475-86. Epub 2016 Mar 22.
    Department of Pathology, Rigshospitalet, Copenhagen, Denmark.
    Mucosal melanomas constitute 1.3% of all melanomas and they may develop in any mucosal membrane. Conjunctival melanomas (0. Read More

    Prognostic value of glucosylceramide synthase and P-glycoprotein expression in oral cavity cancer.
    Int J Clin Oncol 2016 Oct 21;21(5):883-889. Epub 2016 Mar 21.
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
    Background: Glucosylceramide synthase (GCS) and P-glycoprotein (P-gp) overexpression are associated with multidrug resistance in several human cancers. This study investigated the prognostic value of GCS and P-gp in oral cavity squamous cell carcinoma (OSCC).

    Methods: The association between GCS and P-gp overexpression and clinical outcomes was assessed in 186 human clinical specimens of primary tumors obtained from curative surgery. Read More

    Regulation of Oral Squamous Cell Carcinoma Proliferation Through Crosstalk Between SMAD7 and CYLD.
    Cell Physiol Biochem 2016 17;38(3):1209-17. Epub 2016 Mar 17.
    Background/aims: SMAD7 is a key inhibitor of transforming growth factor β (TGFβ) receptor signaling, which regulates the alteration of cancer cell invasiveness through epithelial-mesenchymal cell conversion. Dysfunction of protein ubiquitination plays a critical role in carcinogenesis, whereas the involvement a deubiquitinating enzyme, cylindromatosis gene (CYLD), in the tumor invasion of oral squamous cell carcinoma (OSCC) is unknown.

    Methods: Here, we studied the role of CYLD in regulation of OSCC cell invasion, using clinic specimens and cell lines. Read More

    Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.
    Clin Exp Otorhinolaryngol 2016 Mar 7;9(1):80-4. Epub 2016 Mar 7.
    Department of Clinical and Preventive Dentistry, Oral Pathology Section, School of Dentistry, Federal University of Pernambuco, Recife, Brazil.
    Objectives: Metastasis of melanoma to the head and neck mucosa is a very unusual condition. The aim of this study was to report four cases of patients with metastatic melanoma in the head and neck mucosa treated at a single institution.

    Methods: Clinical data were obtained from the medical records. Read More

    [Oral cavity cancers among young people: Clinical results and prognostic analysis].
    Cancer Radiother 2016 Apr 8;20(2):91-7. Epub 2016 Mar 8.
    Département de radiothérapie, Gustave-Roussy, 114, rue Édouard-Vaillant, 94800 Villejuif, France.
    Purpose: Squamous cell carcinomas of the oral cavity occurring in young people represent a specific entity. Its management and prognosis are controversial. We performed a retrospective chart review of all patients aged less than 40 years old and treated at Gustave-Roussy Cancer Centre for a squamous cell carcinomas of the oral cavity between 1999 and 2011. Read More

    Systemic Radioligand Therapy with (177)Lu Labeled Prostate Specific Membrane Antigen Ligand for Imaging and Therapy in Patients with Metastatic Castration Resistant Prostate Cancer.
    J Urol 2016 Aug 8;196(2):382-91. Epub 2016 Mar 8.
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
    Purpose: We report our initial clinical experience with β -emitting (177)Lu-PSMA-I&T ((177)Lu labeled prostate specific membrane antigen ligand for imaging and therapy) for systemic treatment of metastatic castration resistant prostate cancer.

    Materials And Methods: Patients with metastatic castration resistant prostate cancer who experienced treatment failure with chemotherapy and novel androgen receptor targeted therapy were treated for 8 weeks with up to 4 cycles of (177)Lu-PSMA-I&T. We report safety data, the antitumor response with prostate specific antigen decreases and the radiographic tumor response as well as the clinical outcome with changes in ECOG (Eastern Cooperative Oncology Group) performance status and pain severity. Read More

    Dynasplint Trismus System exercises for trismus secondary to head and neck cancer: a prospective explorative study.
    Support Care Cancer 2016 Aug 8;24(8):3315-23. Epub 2016 Mar 8.
    Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB, Groningen, the Netherlands.
    Purpose: The Dynasplint Trismus System (DTS) can be used to treat trismus secondary to head and neck cancer. We conducted a prospective study with the following aims: (1) to determine the effects of DTS exercises on changes in mouth opening, pain, mandibular function, quality of life (QoL), and symptomatology and (2) to analyze the patients' perception on DTS exercises, including user satisfaction, experiences, comfort, and compliance.

    Methods: The patients were instructed to exercise with the DTS for at least 16 weeks. Read More

    Three Synchronous Atypical Metastases of Clear Cell Renal Carcinoma to the Maxillary Gingiva, Scalp and the Distal Phalanx of the Fifth Digit: A Case Report.
    J Oral Maxillofac Surg 2016 Jun 13;74(6):1286.e1-9. Epub 2016 Feb 13.
    Associate Professor, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA.
    Oral cavity metastasis of malignant tumors is extremely rare and accounts for only 1% of all malignant oral tumors. Renal cell carcinoma (RCC) can metastasize to any part of the body, with a 15% risk of metastasis to the head and neck region when the disease is disseminated and a 1% risk when it is not. RCC also is the third most common infraclavicular neoplasm that metastasizes to the oral cavity, after lung carcinoma in men and breast carcinoma in women. Read More

    Patterns of recurrence after selective postoperative radiation therapy for patients with head and neck squamous cell carcinoma.
    BMC Cancer 2016 Mar 7;16:192. Epub 2016 Mar 7.
    Department of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
    Background: The radiation field for patients with postoperative head and neck squamous cell carcinoma is narrower in our institution than in Western countries to reduce late radiation related toxicities. This strategy is at a risk of loco-regional or distant metastasis. However, because patients are more closely checked than in Western countries by every 1 to 2 months intervals and it is supposed that regional recurrences are identified and salvage surgeries are performed more quickly. Read More

    Plasmacytoma of the Breast: A Report of a Rare Disease.
    Ethiop J Health Sci 2015 Oct;25(4):373-6
    Department of Anaesthesia, University of Calabar Teaching Hospital, Calabar Nigeria.
    Background: Extramedullary plasma cells tumours are rare. Much more rarer is their occurance in the breast tissue. Our aim is to report a single case of this very rare lesion (at least from an African perspective) that we incidentally diagnosed histopathologically as a primary extramedullary lesion in a 53 year old woman. Read More

    Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
    Mayo Clin Proc 2016 Mar;91(3):386-96
    Department of Oncology, Johns Hopkins University and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD.
    Squamous cell carcinoma arises from multiple anatomic subsites in the head and neck region. The risk factors for development of cancers of the oral cavity, oropharynx, hypopharynx, and larynx include tobacco exposure and alcohol dependence, and infection with oncogenic viruses is associated with cancers developing in the nasopharynx, palatine, and lingual tonsils of the oropharynx. The incidence of human papillomavirus-associated oropharyngeal cancer is increasing in developed countries, and by 2020, the annual incidence could surpass that of cervical cancer. Read More

    Selective activator protein-1 inhibitor T-5224 prevents lymph node metastasis in an oral cancer model.
    Cancer Sci 2016 May 26;107(5):666-73. Epub 2016 Apr 26.
    Department of Otorhinolaryngology-Head and Neck Surgery, National Defense Medical College, Tokorozawa, Japan.
    Activator protein-1 (AP-1) is a transcriptional factor that regulates the expression of various genes associated with tumor invasion and migration. The purpose of our study was to assess the therapeutic effects of a novel selective AP-1 inhibitor, T-5224, in preventing lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) in an orthotopic mouse model. We assessed the effect of T-5224 on HNSCC cell invasion, migration, proliferation, and MMP activity by carrying out an in vitro study using an invasion assay, scratch assay, WST-8 assay, and gelatin zymography. Read More

    Parotidectomy for Parotid Cancer.
    Otolaryngol Clin North Am 2016 Apr 17;49(2):415-24. Epub 2016 Feb 17.
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
    Parotidectomy for parotid cancer includes management of primary salivary cancer, metastatic cancer to lymph nodes, and direct extension from surrounding structures or cutaneous malignancies. Preoperative evaluation should provide surgeons with enough information to plan a sound operation and adequately counsel patients. Facial nerve sacrifice is sometimes required; but in preoperative functioning nerves, function should be preserved. Read More

    Staging significance of bone invasion in small-sized (4cm or less) oral squamous cell carcinoma as defined by the American Joint Committee on Cancer.
    Oral Oncol 2016 Apr 12;55:31-6. Epub 2016 Feb 12.
    Department of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea. Electronic address:
    Objectives: The staging significance of bone invasion is controversial in oral squamous cell carcinoma (OSCC) cases with tumors measuring 4cm or less according to the American Joint Committee on Cancer (AJCC). Our aim was to retrospectively examine a large group of patients with OSCC to determine the staging significance of bone invasion.

    Materials And Methods: Three hundred and twenty-three patients with primary OSCC were classified based on tumor size. Read More

    Exercise intervention for the treatment of trismus in head and neck cancer - a prospective two-year follow-up study.
    Acta Oncol 2016 Jun 15;55(6):686-92. Epub 2016 Feb 15.
    a Department of Otorhinolaryngology, Head and Neck Surgery , Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital , Gothenburg , Sweden.
    Background This study aims to investigate the long-term effects of structured trismus intervention in patients with head and neck cancer (HNC) and trismus in terms of mouth opening, trismus-related symptoms and health-related quality of life (HRQL). Material and methods Fifty patients with HNC to receive radiotherapy ± chemotherapy were included in this prospective study along with a matched control group. The intervention group received a 10-week structured exercise with a jaw mobilizing device (TheraBite® jaw device or Engström device). Read More

    Exercise therapy for trismus secondary to head and neck cancer: A systematic review.
    Head Neck 2017 Jan 15;39(1):160-169. Epub 2016 Feb 15.
    Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, The Netherlands.
    Background: Effects of exercise therapy for trismus secondary to head and neck cancer have not been reviewed systematically since 2004.

    Methods: Four databases were searched. The quality of observational studies and randomized controlled trials was assessed. Read More

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