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    4707 results match your criteria Metastatic Neoplasms to the Oral Cavity

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    Oral primary care: an analysis of its impact on the incidence and mortality rates of oral cancer.
    BMC Cancer 2017 Oct 30;17(1):706. Epub 2017 Oct 30.
    Faculty of Medicine, Department of Social Medicine, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
    Background: Oral cancer is a potentially fatal disease, especially when diagnosed in advanced stages. In Brazil, the primary health care (PHC) system is responsible for promoting oral health in order to prevent oral diseases. However, there is insufficient evidence to assess whether actions of the PHC system have some effect on the morbidity and mortality from oral cancer. Read More

    Exercise therapy for trismus secondary to head and neck cancer: A systematic review.
    Head Neck 2017 Nov 14;39(11):2352-2362. Epub 2017 Jul 14.
    Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, The Netherlands.
    Background: Effects of exercise therapy for trismus secondary to head and neck cancer have not been reviewed systematically since 2004.

    Methods: Four databases were searched. The quality of observational studies and randomized controlled trials was assessed. Read More

    Anterograde injection of low-dose urokinase salvages free anterolateral thigh flap: A case report of safe and effective treatment.
    Medicine (Baltimore) 2017 Oct;96(41):e7932
    Department of Plastic Surgery, China Medical University Hospital, Taichung, Taiwan.
    Rationale: A 54-year-old Taiwanese male came to our hospital presented with right retromolar mucoepidermoid carcinoma. Composite resection and right modified radical neck dissection were performed. We then use free anteral lateral thigh flap to reconstruct the defect. Read More

    Metastatic Lymph Node Burden and Survival in Oral Cavity Cancer.
    J Clin Oncol 2017 Nov 7;35(31):3601-3609. Epub 2017 Sep 7.
    All authors: Cedars-Sinai Medical Center, Los Angeles, CA.
    Purpose Current staging systems for oral cavity cancers incorporate lymph node (LN) size and laterality, but place less weight on the total number of positive metastatic nodes. We investigated the independent impact of numerical metastatic LN burden on survival. Methods Adult patients with oral cavity squamous cell carcinoma undergoing upfront surgical resection for curative intent were identified in the National Cancer Data Base between 2004 and 2013. Read More

    [Description of the GORTEC 2017-03 study: Postoperative stereotactic radiotherapy for early stage oropharyngeal and oral cavity cancer with high risk margin (PHRC-K-16-164)].
    Cancer Radiother 2017 Oct 31;21(6-7):527-532. Epub 2017 Aug 31.
    Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, 63011 Clermont-Ferrand, France.
    The GORTEC 2017-03-Stereo-postop study is a phase 2, multicentric, nationwide study, funded by the hospital clinical research program (PHRC). The sponsor is Centre Jean-Perrin in Clermont-Ferrand, in partnership with the GORTEC. The principal investigators are Dr J Biau and Dr M Lapeyre. Read More

    LncRNAAC132217.4, a KLF8-regulated long non-coding RNA, facilitates oral squamous cell carcinoma metastasis by upregulating IGF2 expression.
    Cancer Lett 2017 Oct 18;407:45-56. Epub 2017 Aug 18.
    Institute of Cancer Stem Cell & College of Stomatology, Dalian Medical University, Dalian 116044, China. Electronic address:
    Increasing evidence has revealed the aberrant expression of long non-coding RNAs (lncRNAs) in many cancer types, including oral squamous cell carcinoma (OSCC). However, limited investigations report metastasis-related lncRNAs in OSCC. Herein, we report the identification of dysregulated intergenic lncRNAs in the highly metastatic OSCC cell line, UM-SCC6H. Read More

    [Parotid metastasis from carcinoma of the breast: report of a case and review of the literature].
    Pan Afr Med J 2017 2;27:79. Epub 2017 Jun 2.
    Service d'Oncologie Médicale, CHU Hassan II Fès, Maroc.
    Parotid metastasis from carcinoma of the breast is very rare, only a few cases have been reported in the literature. We here report the case of a 43-year old patient treated for right breast cancer in whom left parotid metastasis (confirmed histologically) occurred two years after the end of the treatment. Read More

    Paraneoplastic mucous membrane pemphigoid with ocular and laryngeal involvement.
    BMJ Case Rep 2017 Aug 11;2017. Epub 2017 Aug 11.
    Département des Neurosciences Cliniques, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
    A 73-year-old woman was treated 8 years previously for synchronous breast and uterine neoplasms. She presented with a severe sore throat, odynophagia, dysphonia, dyspnoea, ocular irritation and weight loss over the last 3 months. Physical examination revealed ulcerations in the oral cavity, posterior pharyngeal wall and supraglottic larynx, nasal crusting, bilateral conjunctivitis and three cutaneous blisters. Read More

    Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis.
    Lancet Oncol 2017 Sep 27;18(9):1221-1237. Epub 2017 Jul 27.
    Department of Radiation Therapy, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.
    Background: The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of altered fractionation within the context of concomitant chemotherapy with the inclusion of new trials.

    Methods: For this updated meta-analysis, we searched bibliography databases, trials registries, and meeting proceedings for published or unpublished randomised trials done between Jan 1, 2009, and July 15, 2015, comparing primary or postoperative conventional fractionation radiotherapy versus altered fractionation radiotherapy (comparison 1) or conventional fractionation radiotherapy plus concomitant chemotherapy versus altered fractionation radiotherapy alone (comparison 2). Read More

    Highly Eribulin-resistant KBV20C Oral Cancer Cells Can Be Sensitized by Co-treatment with the Third-generation P-Glycoprotein Inhibitor, Elacridar, at a Low Dose.
    Anticancer Res 2017 08;37(8):4139-4146
    School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea
    Background/aim: Eribulin mesylate, also called Halaven® (HAL), was recently developed as a microtubule-targeting drug and is used in the clinic for resistant or metastatic cancer. Previously, we showed that P-glycoprotein (P-gp)-overexpressing KBV20C oral cancer cells are highly resistant to HAL compared to sensitive KB cells. This qualitative study was designed to identify specific P-gp inhibitors that increase the sensitivity of highly resistant cancer cells to HAL. Read More

    [Application of muscle pedicled platysma myocutaneous flap in the reconstruction of buccal mucosa defects].
    Hua Xi Kou Qiang Yi Xue Za Zhi 2017 Apr;35(2):162-166
    Centre of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China.
    Objective: This study aimed to explore the main features and advantages of the muscle pedicled platysma myocutaneous flap (PMF), the degree of improvement of flap harvest. To evaluate the application value of the flap in the reconstruction of buccal mucosa carcinoma defects.

    Methods: Twenty-three patients received PMF with MacFee incision to reconstruct buccal mucosa defects that were caused by the resection of precancer lesions and benign and malignant tumors from August 2012 to April 2015. Read More

    Overexpression of glutathione peroxidase 1 predicts poor prognosis in oral squamous cell carcinoma.
    J Cancer Res Clin Oncol 2017 Nov 26;143(11):2257-2265. Epub 2017 Jun 26.
    Department of Otolaryngology, Asan Medical Centre, University of Ulsan College of Medicine, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
    Purpose: Intracellular antioxidant enzymes are commonly upregulated in various cancer types and are associated with treatment outcomes. Because the relationship has rarely been examined in oral squamous cell carcinoma (OSCC), we aimed to evaluate the association between the levels of glutathione peroxidase (GPX)1, GPX4, and thioredoxin reductase (TrxR)1 expression and prognosis in patients with OSCC who underwent curative surgical resection.

    Methods: This study included 233 patients who underwent curative surgery for previously untreated OSCC between 2000 and 2012. Read More

    Oral squamous cell carcinoma patients can be differentiated from healthy individuals with label-free serum proteomics.
    Br J Cancer 2017 Jul 20;117(3):376-384. Epub 2017 Jun 20.
    Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki 00290, Finland.
    Background: No blood biomarkers to detect early oral cavity squamous cell carcinoma (OSCC) without clinical signs exist - diagnosis is solely based on histology of a visible tumour. Most OSCC patients are diagnosed at advanced stage, which leads to significant morbidity and poor survival. Our aim was to find the serum screening or detection biomarkers in OSCC. Read More

    NUT carcinoma presenting in the palate - a case report.
    APMIS 2017 Oct 25;125(10):933-936. Epub 2017 May 25.
    Department of Oral & Maxillofacial Surgery, Rigshospitalet, Copenhagen, Denmark.
    NUT carcinomas (NC) are rare and aggressive tumours characterized by chromosomal rearrangements of the gene encoding for nuclear protein of the testis (NUT) located on chromosome 15q14. This article presents a case of a 60-year-old woman diagnosed with NC presenting as a fast growing primary tumour in the right palate. Further evaluation revealed a tumour mass in the lungs and widespread metastases. Read More

    Clinical and prognostic significance of HIF-1α overexpression in oral squamous cell carcinoma: a meta-analysis.
    World J Surg Oncol 2017 May 18;15(1):104. Epub 2017 May 18.
    Department of Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, Jinan, Shandong, 250012, China.
    Background: Recent studies have indicated an association between hypoxia inducible factor-1 alpha (HIF-1α) expression and poor prognosis in patients with oral squamous cell carcinoma (OSCC); however, definitive evidence of this association is yet to be obtained. We performed a meta-analysis to evaluate the association of HIF-1α expression with clinicopathological characteristics and overall survival (OS) of patients with OSCC.

    Methods: A literature search for relevant studies published in English language as of February 05, 2016, was performed on PubMed, Web of Science, and EMBASE databases. Read More

    Mouth examination performance by children's parents and by adolescents in Fanconi anemia.
    Pediatr Blood Cancer 2017 Nov 13;64(11). Epub 2017 May 13.
    Department of Stomatology, Post Graduate Program in Dentistry, Federal University of Paraná School of Dentistry, Curitiba, Paraná, Brazil.
    Background: Fanconi anemia (FA) is a rare genetic syndrome characterized by increased risk of developing malignant neoplasms, particularly oral squamous cell carcinoma. This study aims to ascertain the extent to which adolescents and guardians/parents of children with FA are aware of their oral cancer risks and assess their ability to perform mouth examination (ME).

    Procedure: A cross-sectional study was conducted among patients with FA (between 6 and 16 years) and their parents. Read More

    The cost of major head and neck cancer surgery.
    N Z Med J 2017 May 12;130(1455):111-119. Epub 2017 May 12.
    Wellington Regional Plastic, Maxillofacial and Burns Unit, Hutt Hospital; and Gillies McIndoe Research Institute, Wellington.
    Aim: This study quantified the cost of major head and neck cancer (HNC) surgery.

    Methods: Consecutive patients undergoing major HNC surgery between July 2007 and June 2012 were identified from our head and neck database. Patient demographics, tumour type, site, stage and types of resection and reconstruction, length of stay and surgical complications occurring within six months of initial surgery were retrospectively analysed. Read More

    Analysis of risk factors for oral cavity and oropharynx cancer in the authors' own material.
    Otolaryngol Pol 2017 Apr;71(2):23-28
    Klinika Otolaryngologii i Onkologii Laryngologicznej II Katedry Otolaryngologii UM w Łodzi Kierownik: prof. dr hab. med. J. Olszewski.
    Introduction: The aim of the study was to analyse the risk factors for oral cavity and oropharynx cancer in peopled examined under the Head and Neck Cancer Awareness Week in 2016, Lodz.

    Material And Methods: In Lodz, 21st September 2016, under the Head and Neck Cancer Awareness Week, 106 people, including 67 women aged 29-77 and 39 men aged 23-84, underwent preventive examinations in the hospital department. Prior to the laryngological examination, the patients were asked to answer questions that referred to their education, medical case history, symptoms, smoking habits with the number of cigarettes per day, alcohol intake, the number of lifetime sexual partners, oral sex engagement, incidents of head and neck cancer in the family history. Read More

    Coexpression of growth differentiation factor 11 and reactive oxygen species in metastatic oral cancer and its role in inducing the epithelial to mesenchymal transition.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jun 20;123(6):697-706. Epub 2017 Mar 20.
    Department of Oral and Maxillofacial Surgery, College of Stomatology, Guangxi Medical University, Nanning, Guangxi, China. Electronic address:
    Objectives: The aim of this study was to investigate growth differentiation factor 11 (GDF11) and reactive oxygen species (ROS) expression in metastatic oral cancer and explored their roles in inducing epithelial to mesenchymal transition (EMT).

    Study Design: The expression of GDF11, ROS, and EMT-related markers was evaluated in primary tumor tissues from patients with oral squamous cell carcinoma (OSCC). SCC-9 cells, a human tongue carcinoma cell line, were treated with recombinant GDF11. Read More

    In vitro and in vivo anticancer activity of posterior salivary gland toxin from the cuttlefish Sepia pharaonis, Ehrenberg (1831).
    Chem Biol Interact 2017 Jun 4;272:10-20. Epub 2017 May 4.
    Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, 603 103, Tamil Nadu, India. Electronic address:
    Posterior salivary gland (PSG) toxins are high molecular weight toxins secreted by cephalopods and gastropods which possess immense potentials in biomedical applications. In the present study, the biomedical potentials of the PSG toxin from the cuttlefish, S. pharaonis was determined in vitro and in vivo. Read More

    Beyond Positive Margins and Extracapsular Extension: Evaluating the Utilization and Clinical Impact of Postoperative Chemoradiotherapy in Resected Locally Advanced Head and Neck Cancer.
    J Clin Oncol 2017 May 13;35(14):1550-1560. Epub 2017 Feb 13.
    Daniel M. Trifiletti and Paul Read, University of Virginia, Charlottesville, VA; Andrew Smith, Nandita Mitra, Surbhi Grover, John N. Lukens, Roger B. Cohen, Alexander Lin, and Samuel Swisher-McClure, University of Pennsylvania, Philadelphia, PA; and William M. Mendenhall, University of Florida, Gainesville, FL.
    Purpose To examine recent utilization and survival outcomes associated with use of adjuvant chemoradiotherapy (CRT) for patients with resected locally advanced head and neck cancer (LAHNC) with negative surgical margins (SM negative) and no extracapsular extension (ECE). Materials and Methods We conducted a retrospective observational cohort study using the National Cancer Database evaluating patients diagnosed in 2004 to 2012 with AJCC stage III to IVB squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx treated with definitive surgery and adjuvant radiotherapy (RT) or CRT. We identified a subset of patients with SM negative and no ECE (n = 10,870). Read More

    Histological Assessment of the Carotid Sheath in Patients With Oral Squamous Cell Carcinoma.
    J Oral Maxillofac Surg 2017 Nov 4;75(11):2465-2476. Epub 2017 Apr 4.
    Associate Professor, Department of Oral Pathology and Microbiology, SDM College of Dental Sciences and Hospital, Sattur, Dharwad, Karnataka, India.
    Purpose: During surgical management of the neck using various types of neck dissection, the carotid sheath is removed, in particular, the part adjacent to the jugular lymph node chain, with the intention of preventing recurrence from the lymphatics present within it. The role of the carotid sheath as a potential origin for nodal recurrence has not been proved thus far. Working in a tissue plane between the carotid sheath and the neurovascular structures of the neck can lead to a greater chance of damage to these structures. Read More

    IQGAP1 is an oncogenic target in canine melanoma.
    PLoS One 2017 26;12(4):e0176370. Epub 2017 Apr 26.
    Program in Epithelial Biology, Stanford University, Stanford, California, United States of America.
    Canine oral mucosal melanoma is an aggressive malignant neoplasm and is characterized by local infiltration and a high metastatic potential. The disease progression is similar to that of human oral melanomas. Whereas human cutaneous melanoma is primarily driven by activating mutations in Braf (60%) or Nras (20%), human mucosal melanoma harbors these mutations much less frequently. Read More

    Inhibition of αvβ3 integrin induces loss of cell directionality of oral squamous carcinoma cells (OSCC).
    PLoS One 2017 24;12(4):e0176226. Epub 2017 Apr 24.
    Department of Morphological Sciences, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, Porto Alegre, RS, Brazil, CEP.
    The connective tissue formed by extracellular matrix (ECM) rich in fibronectin and collagen consists a barrier that cancer cells have to overpass to reach blood vessels and then a metastatic site. Cell adhesion to fibronectin is mediated by αvβ3 and α5β1 integrins through an RGD motif present in this ECM protein, thus making these receptors key targets for cell migration studies. Here we investigated the effect of an RGD disintegrin, DisBa-01, on the migration of human fibroblasts (BJ) and oral squamous cancer cells (OSCC, SCC25) on a fibronectin-rich environment. Read More

    Congenital amelanotic melanoma in a crossbred heifer calf.
    J Vet Diagn Invest 2017 Jul 19;29(4):544-547. Epub 2017 Apr 19.
    Departments of Veterinary Clinical Sciences (Winslow, Gilliam), Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK.
    A large, pedunculated cutaneous mass protruding from the left flank fold and an enlarged left prefemoral lymph node were found on examination of a 3-d-old crossbred Aberdeen Angus heifer. The calf was asymptomatic aside from peripheral lymphadenopathy, and the mass, along with the left prefemoral lymph node, was surgically excised. Histologic examination of the mass and the lymph node revealed a homogeneous population of neoplastic cells that stained positively with immunohistochemical stains S100 and melan A, supporting a diagnosis of congenital amelanotic melanoma with nodal metastasis. Read More

    One-Stage Supramaximal Full-Thickness Wedge Resection of Vascular Lip Anomalies.
    J Oral Maxillofac Surg 2017 Nov 22;75(11):2449-2455. Epub 2017 Mar 22.
    Staff, Vascular Birthmark Institute of New York, Department of Otolaryngology, Lenox Hill and Manhattan Eye, Ear, and Throat Hospitals, New York, NY; Assistant Clinical Professor, Department of Ophthalmology, Harvard Medical School, Boston, MA. Electronic address:
    Purpose: Vascular lip anomalies include infantile hemangiomas, venous malformations, and arteriovenous malformations. Surgical management can be complicated by alterations in horizontal length, vertical height, and lip thickness from the underlying pathology. Additional reconstructive challenges include preservation of oral continence, vermillion definition, and the sublabial sulcus. Read More

    Oral and Cutaneous Lymphomas other than Mycosis Fungoides and Sézary Syndrome in a Mexican Cohort: Recategorization and Evaluation of International Geographical Disparities.
    Indian J Dermatol 2017 Mar-Apr;62(2):158-167
    Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, City, Mexico; Division of Pathology, Instituto Nacional de Cancerología, Mexico City, Mexico.
    Background: Nonmycosis fungoides/Sézary syndrome (non-MF/SS) primary cutaneous lymphomas (PCL) are currently categorized under the 2005-World Health Organization/European Organization for Research and Treatment of Cancer (WHO-EORTC) classification for PCL. These differ in behavior from secondary cutaneous lymphomas (SCL) and to lymphomas limited to the oral cavity (primary oral lymphomas [POL]) both categorized under the 2016-WHO classification for lymphoid neoplasms.

    Aims: This study aims to report the first series of non-MF/SS PCL, SCL, and POL in a Mexican cohort, examine the applicability of current classification systems and compare our findings with those from foreign cohorts. Read More

    Influence of time interval from diagnosis to treatment on survival for oral cavity cancer: A nationwide cohort study.
    PLoS One 2017 7;12(4):e0175148. Epub 2017 Apr 7.
    Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan.
    Objectives: We aimed to explore the relationship between the time interval from diagnosis to treatment and survival of oral cavity squamous cell carcinoma patients.

    Materials And Methods: A population-based study was conducted between 2004 and 2010. Claims data of oral squamous cell carcinoma patients were retrieved from the Taiwan Cancer Registry Database. Read More

    Genome wide profiling in oral squamous cell carcinoma identifies a four genetic marker signature of prognostic significance.
    PLoS One 2017 6;12(4):e0174865. Epub 2017 Apr 6.
    Oral Cancer Research and Coordinating Centre, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
    Background: Cancers of the oral cavity are primarily oral squamous cell carcinomas (OSCCs). Many of the OSCCs present at late stages with an exceptionally poor prognosis. A probable limitation in management of patients with OSCC lies in the insufficient knowledge pertaining to the linkage between copy number alterations in OSCC and oral tumourigenesis thereby resulting in an inability to deliver targeted therapy. Read More

    Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge.
    Diagn Pathol 2017 Apr 5;12(1):32. Epub 2017 Apr 5.
    Postgraduate Program in Dentistry, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
    Background: Oral squamous cell carcinoma (OSCC) accounts over 90% of malignant neoplasms of the oral cavity. This pathological entity is associated to a high mortality rate that has remained unchanged over the past decades. Tumour-associated macrophages (TAMs) are believed to have potential involvement in OSCC progression. Read More

    Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma.
    Tumour Biol 2017 Apr;39(4):1010428317695527
    1 School of Dentistry, Federal University of Goiás, Goiânia, Brazil.
    To investigate hypoxia-induced factor-1 alpha expression in distinct oral squamous cell carcinoma subtypes and topographies and correlate with clinicopathological data. Hypoxia-induced factor-1 alpha expression was assessed by immunohistochemistry in 93 cases of OSCC. Clinical and histopathological data were reviewed from medical records. Read More

    High HMGA2 Expression Correlates with Reduced Recurrence-free Survival and Poor Overall Survival in Oral Squamous Cell Carcinoma.
    Anticancer Res 2017 04;37(4):1891-1899
    Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan, R.O.C.
    Background/aim: High-mobility group AT-hook 2 (HMGA2) is an architectural transcription factor that is expressed in many human neoplasms. Oral squamous cell carcinoma (OSCC) is one of the leading cancers in the world, particularly in Southeast Asia. In this study, the expression level of HMGA2 was determined on tissue microarray of OSCC and its correlation with prognosis of patients was studied. Read More

    Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review.
    BMC Cancer 2017 Mar 28;17(1):225. Epub 2017 Mar 28.
    Department of Otolaryngology (ENT), University of Florida, Gainesville, FL, 32610, USA.
    Background: Follicular thyroid carcinoma (FTC) metastasis to the facial skeleton is exceedingly rare. A case of FTC metastasizing to the mandible is presented and a systematic review of the literature describing thyroid metastasis to the facial skeleton is performed.

    Case Presentation: A 73-year-old female presented with metastatic FTC to the mandible and underwent total thyroidectomy, segmental mandibulectomy, bone impacted fibular free flap reconstruction, and adjuvant radioactive iodine treatment. Read More

    Agreement Between Cytology and Histopathology for Regional Lymph Node Metastasis in Dogs With Melanocytic Neoplasms.
    Vet Pathol 2017 Jul 27;54(4):579-587. Epub 2017 Mar 27.
    1 Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
    Melanocytic neoplasms are common in dogs and frequently occur within the oral cavity or in haired skin. The behavior of melanocytic neoplasms is variable and depends on tumor location, size, and histopathologic features. This study compared cytopathology and histopathology of 32 lymph nodes from 27 dogs diagnosed with melanocytic neoplasms. Read More

    Therapeutic Targeting of Protein Kinase CK2 Gene Expression in Feline Oral Squamous Cell Carcinoma: A Naturally Occurring Large-Animal Model of Head and Neck Cancer.
    Hum Gene Ther Clin Dev 2017 Jun 23;28(2):80-86. Epub 2017 Mar 23.
    4 Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota , Minneapolis, Minnesota.
    Protein kinase CK2 (CK2) is a highly promising target for cancer therapy, and anti-CK2 gene expression therapy has shown effectiveness in rodent models of human head and neck cancer (HNC). To date, there has been no large-animal model of cancer in which to further explore anti-CK2 therapies. Feline oral squamous cell carcinoma (FOSCC) has been proposed as a large-animal model for human HNC, and we have previously shown that CK2 is a rational target in FOSCC. Read More

    Determining the epidemiologic, outcome, and prognostic factors of oral malignant melanoma by using the Surveillance, Epidemiology, and End Results database.
    J Am Dent Assoc 2017 May 18;148(5):288-297. Epub 2017 Mar 18.
    Background: The authors conducted a retrospective analysis to determine the epidemiologic, outcome, and prognostic factors in patients with oral malignant melanoma (OMM).

    Methods: The authors used the US National Cancer Institute's Surveillance, Epidemiology, and End Results database to analyze patients with OMM from 1973 to 2012. Study variables included age, sex, race, decade of diagnosis, extent of disease, tumor size, treatment modality, and socioeconomic status (SES). Read More

    Multiple and Recurrent Squamous Cell Carcinoma of the Oral Cavity After Graft-Versus-Host Disease.
    J Oral Maxillofac Surg 2017 Sep 22;75(9):1899-1905. Epub 2017 Feb 22.
    Associated Professor, Department of Stomatology, Wuhan Union Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, China. Electronic address:
    Oral squamous cell carcinoma (OSCC) is one of the most common secondary solid tumors in patients who have undergone hematopoietic stem cell transplantation (HSCT). However, according to previous reports, multiple and recurrent OSCC is very rare. The presented case shows the susceptibility to the development of secondary malignancies, particularly oral cancer, of patients who present with chronic graft-versus-host disease after HSCT. Read More

    [Preliminary study on the role of voltage-gated sodium channel subtype Nav1.5 in lymph node metastasis of oral squamous cell carcinoma].
    Zhonghua Kou Qiang Yi Xue Za Zhi 2017 Mar;52(3):188-193
    Department of Stomatology, The Fourth Affiliated Hospital of Anhui Medical University, Hefei 230032, China.
    Objective: To investigate the relationship between the expression of voltage-gated sodium channel subtype Nav1.5 in oral squamous cell carcinoma (OSCC) and the occurrence and lymph node metastasis of OSCC. Methods: Totally 10 samples of normal oral mucosa tissue as control group, 26 samples of OSCC as the experimental group was divided into non-metastatic group (n=16) and metastatic group (n=10) according to the presence or absence of lymph node metastasis. Read More

    [Expressions and clinical significance of TGF-βRII and NF-κB in oral squamous cell carcinoma].
    Shanghai Kou Qiang Yi Xue 2016 Dec;25(6):729-733
    Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Stomatology, Chongqing Medical University; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education. Chongqing 401147, China.
    Purpose: To investigate the expression of nuclear factor κappa-B (NF-κB) and transforming growth factor β receptor II (TGF-βRII) and their clinical pathological significance in oral squamous cell carcinoma(OSCC).

    Methods: The expression of NF-κB and TGF-βRII in 60 OSCC samples, 20 adjacent tissues, 29 metastatic lymph nodes and 10 non-metastatic lymph nodes were detected by immunohistological method. Statistical analysis was performed with SPSS 20. Read More

    Overexpression of KAI1/CD82 suppresses in vitro cell growth, migration, invasion and xenograft growth in oral cancer.
    Mol Med Rep 2017 Apr 9;15(4):1527-1532. Epub 2017 Feb 9.
    State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.
    KAI1/CD82 is a metastatic suppressor gene in human prostate cancer and several other types of cancer in humans. The present study aimed to examine the role of the overexpression of KAI1 in the progression of oral cancer. Human KAI1/CD82 cDNA was transfected into OSCC‑15 and 293T cell lines, and its effects on OSCC‑15 cell proliferation, invasion and apoptosis were assessed by performing a 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay, Matrigel invasion and Annexin V‑FITC staining, respectively. Read More

    Update from the 4th Edition of the World Health Organization of Head and Neck Tumours: Tumours of the Oral Cavity and Mobile Tongue.
    Head Neck Pathol 2017 Mar 28;11(1):33-40. Epub 2017 Feb 28.
    Emory University School of Medicine, Atlanta Oral Pathology, 2701 N. Decatur Road, Decatur, GA, 30033, USA.
    There have been several additions and deletions in Chapter 4 on Tumours of the oral cavity and mobile tongue in the 2017 fourth edition of the World Health Organization Classification of Tumours of the Head and Neck. This chapter excludes the oropharynx, which now is a stand-alone chapter acknowledging the uniqueness of the oropharynx from the oral cavity. New entries in Chapter 4 include rhabdomyoma, haemangioma, schwannoma, neurofibroma and myofibroblastic sarcoma in the section titled Soft tissue and neural tumours. Read More

    SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7.
    Exp Cell Res 2017 Mar 22;352(2):357-363. Epub 2017 Feb 22.
    Department of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan. Electronic address:
    Signal-induced proliferation-associated protein 1 (SIPA1) is known to be a GTPase activating protein. Overexpressed SIPA1 is related to metastatic progression in breast and prostate cancers; however, the relevance of SIPA1 in oral squamous cell carcinoma (OSCC) is still unknown. The aim of this study was to examine SIPA1 expression and its functional mechanisms in OSCC. Read More

    [Oral cancer: Risk factors and management].
    Presse Med 2017 Mar 21;46(3):320-330. Epub 2017 Feb 21.
    CHU de Tours, hôpital Trousseau, université François-Rabelais de Tours, service de chirurgie maxillo-faciale et plastique de la face, avenue de la République, 37170 Chambray-lès-Tours, France.
    Oral cavity is the most frequent anatomical subsite of upper aero-digestive tract malignancies. Squamous cell carcinoma is the most common histological type and totalizes more than 95% of oral cancer. Main risk factors are tobacco and alcohol exposure and also potentially malignant lesions. Read More

    Outcome and prognostic factors following curative-intent surgery for oral tumours in dogs: 234 cases (2004 to 2014).
    J Small Anim Pract 2017 Mar 22;58(3):146-153. Epub 2017 Feb 22.
    Department of Surgery, Red Bank Veterinary Hospital, Tinton Falls, NJ 07724, USA.
    Objectives: To describe the long-term outcomes and prognostic factors associated with curative-intent surgery for oral tumours in a large series of dogs.

    Methods: Retrospective review of records for dogs with oral tumours treated with curative-intent surgery. Data collected included signalment, weight, surgical procedure, lymph node staging results, computed tomography results, tumour size, histopathology results including margin evaluation, complications, adjunctive therapies, local recurrence or metastasis, date and cause of death and owner satisfaction. Read More

    Oral mucosal changes induced by anticancer targeted therapies and immune checkpoint inhibitors.
    Support Care Cancer 2017 May 22;25(5):1713-1739. Epub 2017 Feb 22.
    Oral Medicine Department, Institut Claudius Regaud, Institut Universitaire du cancer Toulouse-Oncopole, 1 avenue Irène Joliot-Curie, 31059, Toulouse Cedex, France.
    Development of biological targeted therapies and immune checkpoint inhibitors has redefined the treatment for many cancers; however, the increasing use of new protocols has led to physicians observing a new spectrum of toxicities. To date, oral adverse events induced by these new anticancer therapies have been mainly reported using nonspecific terminology ("stomatitis," "mucosal inflammation," "mucositis") and remain poorly characterized, with the exception of mammalian target of rapamycin (mTOR) inhibitor-associated stomatitis. Oral toxicities of targeted therapies often display very characteristic features which clearly differ from classic oral injuries observed with cytotoxic chemotherapy and/or radiotherapy. Read More

    CD44+ cancer cell-induced metastasis: A feasible neck metastasis model.
    Eur J Pharm Sci 2017 Apr 13;101:243-250. Epub 2017 Feb 13.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology, Key Laboratory of Oral Biomedicine Ministry of Education, Wuhan University, Wuhan, China; Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, China. Electronic address:
    Neck metastasis of oral squamous cell carcinoma (OSCC) indicates a poor prognosis. Few neck metastasis models are currently available for drug trials and clinical research on OSCC. This study constructed a feasible animal model of neck metastasis by using CD44+ stem cell-like cancer cells. Read More

    Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential.
    Cancer Res 2017 May 16;77(9):2363-2374. Epub 2017 Feb 16.
    Division of Tumor and Cellular Biochemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
    Loss of the tumor suppressor NDRG2 has been implicated in the development of oral squamous cell carcinoma (OSCC), acting by modulating PI3K/AKT-mediated dephosphorylation of PTEN at S380/S382/T383 (STT). Here, we show that the majority of OSCC tumors with lymph node metastasis, a major prognostic factor, exhibit high levels of phosphorylated AKT-S473 and PTEN-STT and low levels of NDRG2 expression. In Ndrg2-deficient mice, which develop a wide range of tumors, we developed a model of OSCC by treatment with the tobacco surrogate 4-nitroquinoline-1-oxide (4-NQO). Read More

    Cribriform adenocarcinoma of the minor salivary gland arising in the tonsil with metastasis to a cervical lymph node: A case report with description of fine needle aspiration cytology.
    Diagn Cytopathol 2017 May 16;45(5):468-471. Epub 2017 Feb 16.
    Department of Pathology, University of Kansas School of Medicine, Kansas City, Kansas, 66160.
    Cribriform adenocarcinoma of minor salivary gland (CAMSG) is a rare tumor of the head and neck. We report a case of a 70-year-old female who presented with a 4-5-month history of a left neck mass. CT scan of the neck showed a left neck mass just inferior to the angle of the mandible and left tonsillar prominence. Read More

    Reciprocal regulation of miR-1254 and c-Myc in oral squamous cell carcinoma suppresses EMT-mediated metastasis and tumor-initiating properties through MAPK signaling.
    Biochem Biophys Res Commun 2017 Mar 1;484(4):801-807. Epub 2017 Feb 1.
    Department of Oral Surgery, The Union Hospital of Fujian Medical University, Fuzhou, 350001, Fujian, PR China.
    Aim: This study aimed to determine the effect of miR-1254 on oral squamous cell carcinoma (OSCC) metastasis and the specific mechanism involved.

    Methods: The metastatic properties of OSCC cells were analyzed by transwell assays. The tumor-initiating properties of OSCC cells were analyzed by tumor sphere formation assays. Read More

    Squamous Cell Carcinoma of the Lip-A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction.
    Dermatol Surg 2017 Apr;43(4):494-506
    *Department of Dermatology, University of Massachusetts, Worcester, Massachusetts; †Department of Medicine, Eastern Virginia Medical School, Norfolk, Virginia; ‡Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
    Background: The lip is an anatomic junction for 2 disparate groups of cancer. Cutaneous squamous cell carcinoma (cSCC) is a common malignancy with a favorable prognosis, whereas oral-mucosal squamous cell carcinoma (omSCC) is associated with significantly higher rates of nodal disease and worse outcomes. The squamous cell carcinoma of the lip (lip SCC) is more aggressive than cSCC but less aggressive than omSCC. Read More

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