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    4794 results match your criteria Metastatic Neoplasms to the Oral Cavity

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    A challenging diagnosis: Case report of oral metastasis from gastric adenocarcinoma mimicking pyogenic granuloma.
    Medicine (Baltimore) 2018 Mar;97(13):e9934
    Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo.
    Rationale: Oral metastases occur more commonly in bone, but can also manifest in soft tissues and eventually resemble a reactive lesion. Few cases of oral metastases mimicking reactive lesions in soft tissues have been reported to date.

    Patient Concerns: We report a metastasis of gastric carcinoma (GC) to the oral mucosa without bone involvement in a 43 yom clinically and microscopically mimicking a reactive lesion. Read More

    Engineering Vaccines to Reprogram Immunity against Head and Neck Cancer.
    J Dent Res 2018 Mar 1:22034518764416. Epub 2018 Mar 1.
    1 Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
    The recent Food and Drug Administration's approval of monoclonal antibodies targeting immune checkpoint receptors (ICRs) for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) offers exciting promise to improve patient outcome and reduce morbidities. A favorable response to ICR blockade relies on an extensive collection of preexisting tumor-specific T cells in the tumor microenvironment (TME). ICR blockade reinvigorates exhausted CD8 T cells and enhances immune killing. Read More

    Low Lymphatic Vessel Density Correlates with Lymph Node Metastasis in Oral Squamous Cell Carcinoma.
    J Dent (Shiraz) 2018 Mar;19(1):6-14
    MD Pathology, Dept. of Pathology, Rashtra Sant Tukodoji Regional Cancer Hospital and Research Centre, Nagpur, India.
    Statement Of The Problem: Regional lymph nodes are the nodes draining lymph from region around the tumor and presence of metastatic tumor in regional lymph nodes is the most important prognostic factor for malignant tumors of epithelial origin. Lymphangiogenesis is associated with an increased incidence of regional lymph nodes metastasis and is possibly an essential step for metastasis. Tumor cells secrete lymphangiogenic cytokines, which results in formation of lymphatic vessels within and around the tumor and act as portals for tumor spread. Read More

    A rare case of oral metastasis of colon adenocarcinoma.
    J Stomatol Oral Maxillofac Surg 2018 Feb 21. Epub 2018 Feb 21.
    Service d'odontologie, Aix Marseille University, AP-HM, La Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France. Electronic address:
    Introduction: Metastatic carcinoma of the colon is frequently encountered. In the literature, metastasis of malignant tumors in the buccal cavity are rare. They represent less than 1% of oral malignant lesions. Read More

    Comprehensive evaluation of clinical efficacy and safety of celecoxib combined with chemotherapy in management of gastric cancer.
    Medicine (Baltimore) 2017 Dec;96(51):e8857
    Department of Gastroenterology.
    Background: To evaluate the clinical efficacy and safety of celecoxib combined with chemotherapy in the treatment of gastric cancer.

    Methods: In total, 240 gastric cancer patients undergoing radical gastrectomy followed by adjuvant chemotherapy were randomly assigned into 2 groups. In the experimental group (n = 120), patients were administered with celecoxib-based chemotherapy, and chemotherapy alone was performed in the control group. Read More

    Low-grade myofibroblastic sarcoma of gastric cardia on 18F-FDG positron emission tomography/computed tomography: An extremely rare case report.
    Medicine (Baltimore) 2018 Jan;97(4):e9720
    Department of Nuclear Medicine.
    Rationale: Low-grade myofibroblastic sarcoma (LGMS) is a rare mesenchyme-derived tumor, which usually occurs in head, neck (especially tongue and mouth), and limbs. In this report, we described a case of gastric LGMS by F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT), which has not been reported previously.

    Patient Concerns: A 51-year-old female patient was admitted to our hospital with upper abdominal discomfort for 1 year and gradually increased eating difficulties over the last 3 months. Read More

    A case report of metastatic hepatocellular carcinoma in the mandible and coracoid process: A rare presentation.
    Medicine (Baltimore) 2018 Jan;97(4):e8884
    Department of Hepatology, Hospital Selayang, Batu Caves, Selangor, Malaysia.
    Rationale: We report a rare case of hepatocellular carcinoma (HCC) with metastases to the mandible and coracoid process of scapula without evidence of lung involvement.

    Patients Concerns: The patient was diagnosed with HCC, presented 5 months later with right lower tooth pain, swelling over the right mandible area and right shoulder pain.

    Diagnoses: Histopathological examination of mandible showed findings suggestive of metastatic HCC. Read More

    Head and Neck Cancer Tumor Seeding at the Percutaneous Endoscopic Gastrostomy Site.
    Nutr Clin Pract 2018 Feb 11;33(1):73-80. Epub 2018 Jan 11.
    Coram CVS Specialty Infusion Services, Denver, Colorado, USA.
    The National Institutes of Health National Cancer Institute estimates that over 13,000 new cases of head and neck cancer (HNC) will be diagnosed in 2017. Patients with HNC often require enteral nutrition (EN) via gastrostomy tube to provide nutrition support and hydration because of tumor obstruction of the oropharynx and/or cumulative effects of chemoradiation therapy. The percutaneous endoscopic gastrostomy (PEG) tube has become the preferred technique for EN access because placement is considered a minimally invasive procedure. Read More

    Prosthetic rehabilitation involving the use of implants following a fibula free flap reconstruction in the treatment of Osteosarcoma of the maxilla: a case report.
    Clin Ter 2017 Nov-Dec;168(6):e392-e396
    M.D., D.D.S., Università degli studi di Roma La Sapienza.
    Introduction: Osteosarcoma is an aggressive primary bone tumor composed of connective tissue cells directly producing osteoid and bone. Prosthetic rehabilitations in post-oncological patients after bone reconstruction are not substantially different than those of patients affected by severe atrophy of upper or lower jaw after bone reconstruction. The treatment for patients with a malignant neoplasia of the oral cavity requires multidisciplinary approach by a team of different specialists that follow the patient through the phases of diagnosis, therapy and oral rehabilitation. Read More

    Metastatic retinoblastoma of the parotid and submandibular glands: a rare case report.
    BMC Ophthalmol 2017 Dec 2;17(1):229. Epub 2017 Dec 2.
    Department of Ophthalmology, Tangdu Hospital of Fourth Military Medical University, Xi'an, Shaanxi, China.
    Background: Retinoblastoma is the most common intraocular malignancy occurring in children. It can metastasize to the regional lymph nodes, central nervous system and distant organs usually the bones and bone marrow and very rarely to the soft tissue. Here, we report a case of unilateral retinoblastoma in a 4-year-old girl accompanied by a large metastasis of the parotid and submandibular glands that developed about 6 months previously and gradually increased in size 5 months after enucleation of the left eye. Read More

    Palonosetron Prevents Highly Emetogenic Chemotherapy-induced Nausea and Vomiting in Oral Cancer Patients.
    Anticancer Res 2017 12;37(12):6977-6981
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yamaguchi University, Yamaguchi, Japan.
    Background/aim: To evaluate the efficacy of palonosetron in preventing acute and delayed nausea and vomiting in patients receiving highly emetogenic chemotherapy (HEC) in oral cancer patients.

    Patients And Methods: Oral cancer patients receiving HEC were enrolled; among the 40 patients, 87 courses of chemotherapy were administered. On day 1, 0. Read More

    Case Report: Metastatic Infratemporal Soft Tissue Myeloma Presenting as a Numb Lower Lip.
    Dent Update 2017 Jan;44(1):53-4
    This is a case of a patient presenting to his general dental practitioner (GDP) with altered sensation in his lower lip with no obvious cause. Due to a prompt referral, the patient was investigated and diagnosed with an extramedullary presentation of multiple myeloma. A numb lip can present in general dental practice, although this is not common. Read More

    Roles of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinoma.
    PLoS One 2017 17;12(11):e0187092. Epub 2017 Nov 17.
    Department of Oral and Maxillofacial Pathobiology, School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
    Background: Vascular endothelial growth factor (VEGF) is a highly specific signaling protein for vascular endothelial cells that plays a critical role in tumor growth and invasion through angiogenesis, and may contribute to cell migration and activation of pre-osteoclasts, osteoclasts and some tumor cells.

    Objectives: We aimed to clarify the detailed roles of VEGF-Flt-1 signaling in bone invasion of oral squamous cell carcinoma (OSCC) cells.

    Results: Forty-two (42) of 54 cases with gingival SCC (77. Read More

    Oral primary care: an analysis of its impact on the incidence and mortality rates of oral cancer.
    BMC Cancer 2017 Oct 30;17(1):706. Epub 2017 Oct 30.
    Faculty of Medicine, Department of Social Medicine, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
    Background: Oral cancer is a potentially fatal disease, especially when diagnosed in advanced stages. In Brazil, the primary health care (PHC) system is responsible for promoting oral health in order to prevent oral diseases. However, there is insufficient evidence to assess whether actions of the PHC system have some effect on the morbidity and mortality from oral cancer. Read More

    Limited evidence for interventions to treat oral leukoplakia.
    Evid Based Dent 2017 10;18(3):92-93
    New York University College of Dentistry, New York, USA.
    Data sourcesCochrane Oral Health's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline Ovid, Embase, Ovid, CancerLit via PubMed. MetaRegister of Controlled Trials, ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform were searched for ongoing trials. Read More

    Exercise therapy for trismus secondary to head and neck cancer: A systematic review.
    Head Neck 2017 Nov 14;39(11):2352-2362. Epub 2017 Jul 14.
    Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, The Netherlands.
    Background: Effects of exercise therapy for trismus secondary to head and neck cancer have not been reviewed systematically since 2004.

    Methods: Four databases were searched. The quality of observational studies and randomized controlled trials was assessed. Read More

    Anterograde injection of low-dose urokinase salvages free anterolateral thigh flap: A case report of safe and effective treatment.
    Medicine (Baltimore) 2017 Oct;96(41):e7932
    Department of Plastic Surgery, China Medical University Hospital, Taichung, Taiwan.
    Rationale: A 54-year-old Taiwanese male came to our hospital presented with right retromolar mucoepidermoid carcinoma. Composite resection and right modified radical neck dissection were performed. We then use free anteral lateral thigh flap to reconstruct the defect. Read More

    "Atypical" salivary gland fine needle aspiration: Risk of malignancy and interinstitutional variability.
    Diagn Cytopathol 2017 Dec 29;45(12):1088-1094. Epub 2017 Sep 29.
    Department of Laboratory Medicine and Pathology, Temple University Hospital, Pennsylvania.
    Background: Fine needle aspiration (FNA) is widely used in the diagnosis of salivary gland lesions. Salivary gland FNAs are often difficult to diagnose because of morphologic heterogeneity, a small but significant number of the FNAs yield "atypical" diagnosis. However, systematic evaluation of the risk of malignancy (ROM) of the atypical diagnoses across institutions and the variability of ROM among institutions are still lacking. Read More

    A randomized, phase 2 study of cetuximab plus cisplatin with or without paclitaxel for the first-line treatment of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck.
    Ann Oncol 2017 Nov;28(11):2820-2826
    Head and Neck Medical Oncology, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan University of Milan, Milan.
    Background: B490 (EudraCT# 2011-002564-24) is a randomized, phase 2b, noninferiority study investigating the efficacy and safety of first-line cetuximab plus cisplatin with/without paclitaxel (CetCis versus CetCisPac) in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN).

    Patients And Methods: Eligible patients had confirmed R/M SCCHN (oral cavity/oropharynx/larynx/hypopharynx/paranasal sinus) and no prior therapy for R/M disease. Cetuximab was administered on day 1 (2-h infusion, 400 mg/m2), then weekly (1-h infusions, 250 mg/m2). Read More

    [Oral cancer -diagnosis and therapy-.]
    Clin Calcium 2017;27(10):1427-1433
    Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Japan.
    Oral cancer is a malignant neoplasm that occurs in the oral cavity. Squamous cell carcinoma accounts for over 90%of the oral cancers, and others include adenocarcinoma derived from minor salivary gland, sarcoma, malignant lymphoma and metastatic cancer. The number of oral cancer patients in Japan is about 3-times higher than the current number. Read More

    Metastatic Lymph Node Burden and Survival in Oral Cavity Cancer.
    J Clin Oncol 2017 Nov 7;35(31):3601-3609. Epub 2017 Sep 7.
    All authors: Cedars-Sinai Medical Center, Los Angeles, CA.
    Purpose Current staging systems for oral cavity cancers incorporate lymph node (LN) size and laterality, but place less weight on the total number of positive metastatic nodes. We investigated the independent impact of numerical metastatic LN burden on survival. Methods Adult patients with oral cavity squamous cell carcinoma undergoing upfront surgical resection for curative intent were identified in the National Cancer Data Base between 2004 and 2013. Read More

    Solitary Fibrous Tumors of the Head and Neck: A Multi-Institutional Clinicopathologic Study.
    Am J Surg Pathol 2017 Dec;41(12):1642-1656
    *Departments of Pathology and Surgery, VCU School of Medicine, Richmond, VA †Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA §Biostatistics Facility, University of Pittsburgh Cancer Institute **Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA ∥Department of Pathology, SUNY Upstate Medical University, Syracuse, NY Departments of ‡Pathology ¶Dermatology ††Oral and Maxillofacial Surgery, University of Michigan Health System, Ann Arbor #Department of Urology, Henry Ford Health System, Detroit, MI.
    Solitary fibrous tumors (SFTs) of the head and neck are uncommon. Lesions previously diagnosed in the head and neck as hemangiopericytomas (HPCs), giant cell angiofibromas (GCAs), and orbital fibrous histiocytomas (OFHs) are now recognized as within the expanded spectrum of SFTs. To better understand the clinicopathologic profile of head and neck SFTs, we performed a multi-institutional study of 88 examples. Read More

    [Description of the GORTEC 2017-03 study: Postoperative stereotactic radiotherapy for early stage oropharyngeal and oral cavity cancer with high risk margin (PHRC-K-16-164)].
    Cancer Radiother 2017 Oct 31;21(6-7):527-532. Epub 2017 Aug 31.
    Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, 63011 Clermont-Ferrand, France.
    The GORTEC 2017-03-Stereo-postop study is a phase 2, multicentric, nationwide study, funded by the hospital clinical research program (PHRC). The sponsor is Centre Jean-Perrin in Clermont-Ferrand, in partnership with the GORTEC. The principal investigators are Dr J Biau and Dr M Lapeyre. Read More

    Metastatic Basal Cell Adenocarcinoma of Submandibular Gland to the Spine: An Extremely Rare Condition.
    World Neurosurg 2017 Dec 24;108:989.e9-989.e14. Epub 2017 Aug 24.
    Spine Unit, Institute of Orthopaedics, Lerdsin Hospital, Bangkok, Thailand.
    Background: Basal cell adenocarcinomas are rare malignant neoplasms of salivary glands, accounting for <1% of salivary gland tumors. Few cases of distant metastases have been reported.

    Case Description: A 50-year-old Thai man was diagnosed with basal cell adenocarcinoma of the submandibular gland with pulmonary and cervical spine metastases with progressive myelopathy. Read More

    LncRNAAC132217.4, a KLF8-regulated long non-coding RNA, facilitates oral squamous cell carcinoma metastasis by upregulating IGF2 expression.
    Cancer Lett 2017 10 18;407:45-56. Epub 2017 Aug 18.
    Institute of Cancer Stem Cell & College of Stomatology, Dalian Medical University, Dalian 116044, China. Electronic address:
    Increasing evidence has revealed the aberrant expression of long non-coding RNAs (lncRNAs) in many cancer types, including oral squamous cell carcinoma (OSCC). However, limited investigations report metastasis-related lncRNAs in OSCC. Herein, we report the identification of dysregulated intergenic lncRNAs in the highly metastatic OSCC cell line, UM-SCC6H. Read More

    [Parotid metastasis from carcinoma of the breast: report of a case and review of the literature].
    Pan Afr Med J 2017 2;27:79. Epub 2017 Jun 2.
    Service d'Oncologie Médicale, CHU Hassan II Fès, Maroc.
    Parotid metastasis from carcinoma of the breast is very rare, only a few cases have been reported in the literature. We here report the case of a 43-year old patient treated for right breast cancer in whom left parotid metastasis (confirmed histologically) occurred two years after the end of the treatment. Read More

    Tumor DNA: an emerging biomarker in head and neck cancer.
    Cancer Metastasis Rev 2017 Sep;36(3):515-523
    Pritzker School of Medicine, University of Chicago, 5841 S. Maryland Avenue, MC 1035, Chicago, IL, 60637, USA.
    Head and neck cancer (HNC) includes a diverse range of malignancies arising commonly from mucosal epithelia of the upper aerodigestive tract. Head and neck squamous cell carcinoma (HNSCC), the most common form of HNC, develops in the oral cavity, pharynx, and larynx and is associated with tobacco exposure, alcohol abuse, and infection with oncogenic viruses. Despite global advances in cancer care, HNSCC often presents with advanced disease and is associated with poor 5-year survival of ~50%. Read More

    Paraneoplastic mucous membrane pemphigoid with ocular and laryngeal involvement.
    BMJ Case Rep 2017 Aug 11;2017. Epub 2017 Aug 11.
    Département des Neurosciences Cliniques, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
    A 73-year-old woman was treated 8 years previously for synchronous breast and uterine neoplasms. She presented with a severe sore throat, odynophagia, dysphonia, dyspnoea, ocular irritation and weight loss over the last 3 months. Physical examination revealed ulcerations in the oral cavity, posterior pharyngeal wall and supraglottic larynx, nasal crusting, bilateral conjunctivitis and three cutaneous blisters. Read More

    EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis.
    Oncogene 2017 Nov 31;36(47):6542-6554. Epub 2017 Jul 31.
    Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan, ROC.
    Current anti-epidermal growth factor receptor (EGFR) therapy for oral cancer does not provide satisfactory efficacy due to drug resistance or reduced EGFR level. As an alternative candidate target for therapy, here we identified an oncogene, ROS1, as an important driver for oral squamous cell carcinoma (OSCC) metastasis. Among tumors from 188 oral cancer patients, upregulated ROS1 expression strongly correlated with metastasis to lung and lymph nodes. Read More

    Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis.
    Lancet Oncol 2017 Sep 27;18(9):1221-1237. Epub 2017 Jul 27.
    Department of Radiation Therapy, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.
    Background: The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of altered fractionation within the context of concomitant chemotherapy with the inclusion of new trials.

    Methods: For this updated meta-analysis, we searched bibliography databases, trials registries, and meeting proceedings for published or unpublished randomised trials done between Jan 1, 2009, and July 15, 2015, comparing primary or postoperative conventional fractionation radiotherapy versus altered fractionation radiotherapy (comparison 1) or conventional fractionation radiotherapy plus concomitant chemotherapy versus altered fractionation radiotherapy alone (comparison 2). Read More

    Highly Eribulin-resistant KBV20C Oral Cancer Cells Can Be Sensitized by Co-treatment with the Third-generation P-Glycoprotein Inhibitor, Elacridar, at a Low Dose.
    Anticancer Res 2017 08;37(8):4139-4146
    School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea
    Background/aim: Eribulin mesylate, also called Halaven® (HAL), was recently developed as a microtubule-targeting drug and is used in the clinic for resistant or metastatic cancer. Previously, we showed that P-glycoprotein (P-gp)-overexpressing KBV20C oral cancer cells are highly resistant to HAL compared to sensitive KB cells. This qualitative study was designed to identify specific P-gp inhibitors that increase the sensitivity of highly resistant cancer cells to HAL. Read More

    Inhibitory Growth of Oral Squamous Cell Carcinoma Cancer via Bacterial Prodigiosin.
    Mar Drugs 2017 Jul 15;15(7). Epub 2017 Jul 15.
    Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan.
    Chemotherapy drugs for oral cancers always cause side effects and adverse effects. Currently natural sources and herbs are being searched for treated human oral squamous carcinoma cells (OSCC) in an effort to alleviate the causations of agents in oral cancers chemotherapy. This study investigates the effect of prodigiosin (PG), an alkaloid and natural red pigment as a secondary metabolite of , to inhibit human oral squamous carcinoma cell growth; thereby, developing a new drug for the treatment of oral cancer. Read More

    [Application of muscle pedicled platysma myocutaneous flap in the reconstruction of buccal mucosa defects].
    Hua Xi Kou Qiang Yi Xue Za Zhi 2017 Apr;35(2):162-166
    Centre of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China.
    Objective: This study aimed to explore the main features and advantages of the muscle pedicled platysma myocutaneous flap (PMF), the degree of improvement of flap harvest. To evaluate the application value of the flap in the reconstruction of buccal mucosa carcinoma defects.

    Methods: Twenty-three patients received PMF with MacFee incision to reconstruct buccal mucosa defects that were caused by the resection of precancer lesions and benign and malignant tumors from August 2012 to April 2015. Read More

    Metastatic cutaneous squamous cell carcinoma of the parotid gland: prognostic factors.
    J Laryngol Otol 2018 Mar 5;132(3):264-269. Epub 2017 Jul 5.
    Department of Otolaryngology Head and Neck Surgery,Christchurch Hospital,New Zealand.
    Background: Metastatic cutaneous squamous cell carcinoma is the most common parotid malignancy in Australasia. Prognostic indicators are not clearly defined and the extent of surgical resection required is controversial.

    Methods: A retrospective analysis was conducted of 63 patients who underwent surgery for metastatic cutaneous squamous cell carcinoma of the parotid gland at a tertiary hospital over a 10-year period. Read More

    Overexpression of glutathione peroxidase 1 predicts poor prognosis in oral squamous cell carcinoma.
    J Cancer Res Clin Oncol 2017 Nov 26;143(11):2257-2265. Epub 2017 Jun 26.
    Department of Otolaryngology, Asan Medical Centre, University of Ulsan College of Medicine, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
    Purpose: Intracellular antioxidant enzymes are commonly upregulated in various cancer types and are associated with treatment outcomes. Because the relationship has rarely been examined in oral squamous cell carcinoma (OSCC), we aimed to evaluate the association between the levels of glutathione peroxidase (GPX)1, GPX4, and thioredoxin reductase (TrxR)1 expression and prognosis in patients with OSCC who underwent curative surgical resection.

    Methods: This study included 233 patients who underwent curative surgery for previously untreated OSCC between 2000 and 2012. Read More

    Oral squamous cell carcinoma patients can be differentiated from healthy individuals with label-free serum proteomics.
    Br J Cancer 2017 Jul 20;117(3):376-384. Epub 2017 Jun 20.
    Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki 00290, Finland.
    Background: No blood biomarkers to detect early oral cavity squamous cell carcinoma (OSCC) without clinical signs exist - diagnosis is solely based on histology of a visible tumour. Most OSCC patients are diagnosed at advanced stage, which leads to significant morbidity and poor survival. Our aim was to find the serum screening or detection biomarkers in OSCC. Read More

    NCCN Guidelines Insights: Head and Neck Cancers, Version 2.2017.
    J Natl Compr Canc Netw 2017 Jun;15(6):761-770
    From Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Duke Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; Massachusetts General Hospital Cancer Center; Moffitt Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Mayo Clinic Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Roswell Park Cancer Institute; Huntsman Cancer Institute at the University of Utah; University of Colorado Cancer Center; Fred & Pamela Buffett Cancer Center; City of Hope Comprehensive Cancer Center; UC San Diego Moores Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center-James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Wisconsin Carbone Cancer Center; University of Michigan Comprehensive Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; and National Comprehensive Cancer Network.
    The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary sinuses, and salivary glands. Recommendations are also provided for occult primary of the head and neck (H&N), and separate algorithms have been developed by the panel for very advanced H&N cancers. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding the increase in human papillomavirus-associated oropharyngeal cancer and the availability of immunotherapy agents for treatment of patients with recurrent or metastatic H&N cancer. Read More

    Bifunctional Enzyme JMJD6 Contributes to Multiple Disease Pathogenesis: New Twist on the Old Story.
    Biomolecules 2017 Jun 1;7(2). Epub 2017 Jun 1.
    Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, 4101 Woolworth Avenue, Omaha, NE 68105, USA.
    Jumonji domain-containing protein 6 (JMJD6) is a non-heme Fe(II) 2-oxoglutarate (2OG)-dependent oxygenase with arginine demethylase and lysyl hydroxylase activities. Its initial discovery as a dispensable phosphatidylserine receptor (PSR) in the cell membrane of macrophages for phagocytosis was squashed by newer studies which revealed its nuclear localization and bifunctional enzymatic activity. Though its interaction with several nuclear and cytoplasmic target proteins has been demonstrated, the exact mechanisms and clinical significance of these various biologic interplays are not yet well established. Read More

    Small cell carcinoma of the head and neck: An analysis of the National Cancer Database.
    Oral Oncol 2017 Jun 25;69:92-98. Epub 2017 Apr 25.
    Department of Human Oncology, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address:
    Purpose/objective(s): To evaluate treatment trends and overall survival of patients with small cell carcinoma of the head and neck region.

    Materials/methods: Patients from 2004 to 2012 were identified from the National Cancer Database. Patient demographics and overall survival were analyzed. Read More

    Outcome of recurrent and metastatic head and neck squamous cell cancer patients after first line platinum and cetuximab therapy.
    Oral Oncol 2017 Jun 9;69:33-37. Epub 2017 Apr 9.
    Fondazione IRCCS Istituto Nazionale dei Tumori, Head and Neck Medical Oncology Dept., Via Venezian 1, I-20133 Milan, Italy.
    Objectives: Second-line chemotherapy in recurrent and/or metastatic head and neck cancer (r/mHNSCC) patients showed dismal results with limited tumor response and reduced life expectancy. Outside of clinical trials, data on efficacy of second line treatment after first line anti-EGFR-AB combination therapy are not available.

    Material And Methods: Data regarding r/mHNSCC consecutive pts treated with cetuximab and platinum from 2009 to 2014 at our center were retrospectively collected. Read More

    NUT carcinoma presenting in the palate - a case report.
    APMIS 2017 Oct 25;125(10):933-936. Epub 2017 May 25.
    Department of Oral & Maxillofacial Surgery, Rigshospitalet, Copenhagen, Denmark.
    NUT carcinomas (NC) are rare and aggressive tumours characterized by chromosomal rearrangements of the gene encoding for nuclear protein of the testis (NUT) located on chromosome 15q14. This article presents a case of a 60-year-old woman diagnosed with NC presenting as a fast growing primary tumour in the right palate. Further evaluation revealed a tumour mass in the lungs and widespread metastases. Read More

    Patterns of Treatment Failure and Postrecurrence Outcomes Among Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma After Chemoradiotherapy Using Modern Radiation Techniques.
    JAMA Oncol 2017 Nov;3(11):1487-1494
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
    Importance: Even though 15% to 50% of patients with head and neck squamous cell carcinoma (HNSCC) experience recurrence, relatively little is known regarding patterns of treatment failure and postrecurrence outcomes after chemoradiotherapy using modern radiation techniques (intensity-modulated radiotherapy [IMRT]). Recurrence patterns are significantly affected by variations in the quality of radiotherapy, which may confound findings from multicenter trials.

    Objective: To assess patterns of treatment failure and postrecurrence outcomes for patients with HNSCC treated with contemporary radiotherapy techniques. Read More

    Clinical and prognostic significance of HIF-1α overexpression in oral squamous cell carcinoma: a meta-analysis.
    World J Surg Oncol 2017 May 18;15(1):104. Epub 2017 May 18.
    Department of Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, Jinan, Shandong, 250012, China.
    Background: Recent studies have indicated an association between hypoxia inducible factor-1 alpha (HIF-1α) expression and poor prognosis in patients with oral squamous cell carcinoma (OSCC); however, definitive evidence of this association is yet to be obtained. We performed a meta-analysis to evaluate the association of HIF-1α expression with clinicopathological characteristics and overall survival (OS) of patients with OSCC.

    Methods: A literature search for relevant studies published in English language as of February 05, 2016, was performed on PubMed, Web of Science, and EMBASE databases. Read More

    Mouth examination performance by children's parents and by adolescents in Fanconi anemia.
    Pediatr Blood Cancer 2017 Nov 13;64(11). Epub 2017 May 13.
    Department of Stomatology, Post Graduate Program in Dentistry, Federal University of Paraná School of Dentistry, Curitiba, Paraná, Brazil.
    Background: Fanconi anemia (FA) is a rare genetic syndrome characterized by increased risk of developing malignant neoplasms, particularly oral squamous cell carcinoma. This study aims to ascertain the extent to which adolescents and guardians/parents of children with FA are aware of their oral cancer risks and assess their ability to perform mouth examination (ME).

    Procedure: A cross-sectional study was conducted among patients with FA (between 6 and 16 years) and their parents. Read More

    The cost of major head and neck cancer surgery.
    N Z Med J 2017 May 12;130(1455):111-119. Epub 2017 May 12.
    Wellington Regional Plastic, Maxillofacial and Burns Unit, Hutt Hospital; and Gillies McIndoe Research Institute, Wellington.
    Aim: This study quantified the cost of major head and neck cancer (HNC) surgery.

    Methods: Consecutive patients undergoing major HNC surgery between July 2007 and June 2012 were identified from our head and neck database. Patient demographics, tumour type, site, stage and types of resection and reconstruction, length of stay and surgical complications occurring within six months of initial surgery were retrospectively analysed. Read More

    Parotidectomy using the Harmonic scalpel: ten years of experience at a rural academic health center.
    Head Face Med 2017 May 11;13(1). Epub 2017 May 11.
    Department of Otolaryngology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
    Background: Parotidectomy is one of the most commonly performed procedures by otorhinolaryngologists. Traditionally dissection is performed with a combination of a steel scalpel and bipolar cautery; however, starting in the early 2000s, the Harmonic scalpel has provided an alternative method for dissection and hemostasis. The purpose of this study is to compare operative time, blood loss, complications, and cost between the Harmonic scalpel and steel scalpel plus bipolar cautery for superficial and total parotidectomy. Read More

    Metastasis of a Renal Collecting Duct Adenocarcinoma to the Oral Cavity After Tooth Extraction.
    J Craniofac Surg 2017 Jun;28(4):e398-e399
    *Department of Pathology, Faculty of Medicine †Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University, Gaziantep ‡Department of Pathology, Faculty of Medicine, TOBB Economics and Technology, Ankara, Turkey.
    Metastatic tumors rarely occur in the oral cavity. The most common of the oral metastases are lung cancers in males, and breast and genital cancers in females. The most common primary tumor metastasis to the oral cavity is from the lung, kidney, liver, prostate, and colorectal cancers. Read More

    Analysis of risk factors for oral cavity and oropharynx cancer in the authors' own material.
    Otolaryngol Pol 2017 Apr;71(2):23-28
    Klinika Otolaryngologii i Onkologii Laryngologicznej II Katedry Otolaryngologii UM w Łodzi Kierownik: prof. dr hab. med. J. Olszewski.
    Introduction: The aim of the study was to analyse the risk factors for oral cavity and oropharynx cancer in peopled examined under the Head and Neck Cancer Awareness Week in 2016, Lodz.

    Material And Methods: In Lodz, 21st September 2016, under the Head and Neck Cancer Awareness Week, 106 people, including 67 women aged 29-77 and 39 men aged 23-84, underwent preventive examinations in the hospital department. Prior to the laryngological examination, the patients were asked to answer questions that referred to their education, medical case history, symptoms, smoking habits with the number of cigarettes per day, alcohol intake, the number of lifetime sexual partners, oral sex engagement, incidents of head and neck cancer in the family history. Read More

    Surgical Treatment for Pulmonary Metastasis of Head and Neck Cancer: Study of 58 Cases.
    Ann Thorac Cardiovasc Surg 2017 Aug 9;23(4):169-174. Epub 2017 May 9.
    Division of Thoracic Surgery, Saitama Cancer Center, Kitaadachi-gun, Saitama, Japan.
    Purpose: Although the number of surgeries performed for pulmonary metastasis of head and neck cancer has been increasing, there have been few reports of the surgical effectiveness. We collected the data of surgeries performed in our facility in order to discuss the surgical performance and indication.

    Methods: We retrospectively examined the prognosis and predictors for 58 patients with pulmonary metastasis of head and neck cancer who underwent a surgery in our facility during the 15-year period, from January 2000 to December 2015. Read More

    Whole-brain Irradiation Field Design: A Comparison of Parotid Dose.
    Med Dosim 2017 Summer;42(2):145-149. Epub 2017 May 4.
    Department of Radiation Oncology, Columbia University Medical Center, 622 West 168th Street, BNH B-11, New York, NY 10032; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032. Electronic address:
    Whole-brain radiation therapy (WBRT) plays an important role in patients with diffusely metastatic intracranial disease. Whether the extent of the radiation field design to C1 or C2 affects parotid dose and risk for developing xerostomia is unknown. The goal of this study is to examine the parotid dose based off of the inferior extent of WBRT field to either C1 or C2. Read More

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