1,219,909 results match your criteria Metastatic Neoplasms to the Oral Cavity


Efficacy of dupilumab in chronic prurigo and chronic idiopathic pruritus: A systematic review of current evidence and analysis of response predictors.

J Eur Acad Dermatol Venereol 2022 May 15. Epub 2022 May 15.

Department of Dermatology, CHRU de Nancy, 6 rue du Morvan, 54500 Vandœuvre lès, Nancy, France.

Dupilumab has demonstrated a great reduction on chronic pruritus that is the hallmark of atopic dermatitis (AD). Underscoring relevant pathogenesis similarities emerging from AD, chronic idiopathic pruritus (CIP) and chronic prurigo (CP), several authors suggested the beneficial role of dupilumab in these conditions. The evidence on this subject is limited with no precise data available. Read More

View Article and Full-Text PDF

Analgesic effect of auricular point acupressure for acute pain in patients with dementia: study protocol for a randomized controlled trial.

Trials 2022 May 14;23(1):404. Epub 2022 May 14.

School of Nursing and Midwifery, Edith Cowan University, 270 Joondalup Dr, Joondalup, WA, 6027, Australia.

Background: Common and frequent as acute pain is, it is often underestimated and undertreated in older people with dementia in nursing homes and inadequate pain management remains an issue.

Methods: The study is designed to be a randomized, sham-controlled trial and is underway in nursing homes located in China. A total of 206 dementia patients are being recruited from nursing homes in Yinchuan, China. Read More

View Article and Full-Text PDF

Enhancement of antitumor immunotherapy using mitochondria-targeted cancer cell membrane-biomimetic MOF-mediated sonodynamic therapy and checkpoint blockade immunotherapy.

J Nanobiotechnology 2022 May 14;20(1):228. Epub 2022 May 14.

Department of Ultrasound in Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, No. 88 Jiefang Road, Shangcheng District, Hangzhou, 310009, People's Republic of China.

Immunotherapeutic interventions represent a promising approach to treating cancer, with strategies such as immune checkpoint blockade (ICB), immunogenic sonodynamic therapy (SDT), and immune adjuvant T cell delivery having exhibited clinical promise. In this report, we describe the use of cancer cell membrane-coated triphenylphosphonium (TPP) decorated nano-metal-organic framework (nMOF) constructs [Zr-TCPP(TPP)/[email protected]] that were used to generate homologous, mitochondria-targeted platforms with a high rate of sonosensitizer loading. This construct was utilized to simultaneously promote tumor antigen presentation via enhancing SDT while synergistically promoting dendritic cell (DC) maturation through the delivery of the Toll-like receptor agonist R837. Read More

View Article and Full-Text PDF

Dental caries according to CAST among Zambian adolescents; pattern, socio-demographic and behavioral correlates.

BMC Oral Health 2022 May 14;22(1):181. Epub 2022 May 14.

Department of Public Health, Michael Chilufya Sata School of Medicine, The Copperbelt University, Ndola, Zambia.

Background: Dental Caries affect more than half of children and adolescents globally and more so in Africa. Most caries studies in Africa are based on DMFT index which does not assess early carious lesions making early prevention and minimal invasive treatment impossible. This study therefore aimed at determining pattern, socio-demographic and behavioral correlates of dental caries according to Caries Assessment and Treatment Spectrum (CAST). Read More

View Article and Full-Text PDF

Predictors of loss to follow-up among adult tuberculosis patients in Southern Ethiopia: a retrospective follow-up study.

BMC Public Health 2022 May 14;22(1):976. Epub 2022 May 14.

KNCV Tuberculosis Foundation, Hague, The Netherlands.

Background: Loss to follow-up (LTFU) from tuberculosis (TB) treatment and care is a major public health problem as patients can be infectious and also may develop a multi-drug resistant TB (MDR-TB). The study aimed to assess whether LTFU differs by the distance TB patients travelled to receive care from the nearest health facility.

Methods: A total of 402 patient cards of TB patients who received care were reviewed from March 1-30, 2020. Read More

View Article and Full-Text PDF

Effect of intratracheal dexmedetomidine combined with ropivacaine on postoperative sore throat: a prospective randomised double-blinded controlled trial.

BMC Anesthesiol 2022 May 14;22(1):144. Epub 2022 May 14.

Department of Anaesthesiology, The Third Affiliated Hospital of Anhui Medical University, The First People's Hospital of Hefei), 390 Huaihe Road, Hefei, 230061, Anhui, China.

Background: The present study aimed to investigate whether intratracheal dexmedetomidine combined with ropivacaine reduces the severity and incidence of postoperative sore throat after tracheal intubation under general anaesthesia.

Methods: Two hundred patients with American Society of Anaesthesiologists physical status I-II who were subjected to general anaesthesia were randomly divided into four groups, namely, Group D, Group R, Group DR and Group S; these groups received intratracheal dexmedetomidine (1 µg/kg), 0.8% ropivacaine (40 mg), dexmedetomidine (1 µg/kg) combined with 0. Read More

View Article and Full-Text PDF

Recanalization of thrombosed aneurysmal hemodialysis arterovenous fistulas using a hybrid technique based on data from a single center.

BMC Nephrol 2022 May 14;23(1):185. Epub 2022 May 14.

Department of Nephropathy, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, P.R. China.

Objective: To explore the technical specifications and clinical outcomes of thrombosed aneurysmal haemodialysis arteriovenous fistula (AVF) treated with ultrasound-guided percutaneous transluminal angioplasty combined with minimal aneurysmotomy.

Methods: This case series study included 11 patients who had thrombosed aneurysmal AVF and underwent salvage procedures over a 13-month period. All procedures were performed under duplex guidance. Read More

View Article and Full-Text PDF

Evaluation of an individualized, tablet-based physiotherapy training programme for patients with Parkinson's disease: the ParkProTrain study, a quasi-randomised controlled trial.

BMC Neurol 2022 May 14;22(1):176. Epub 2022 May 14.

Department Rehabilitation Sciences, Institute for Social Medicine and Epidemiology, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.

Background: Regular physical activity is of great relevance in Parkinson's disease (PD). It is part of the inpatient multimodal Parkinson's complex treatment (MKP) in Germany. However, there is often a lack of human resources in outpatient settings to continue an interprofessional approach. Read More

View Article and Full-Text PDF

Predictors of very early stroke recurrence in the POINT trial population.

BMC Neurol 2022 May 14;22(1):177. Epub 2022 May 14.

Department of Neurology, MC2030, The University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA.

Background: Recent trials of acute secondary prevention in patients with minor ischemic stroke or transient ischemic attack (TIA) have demonstrated high rates of early recurrence within days of the initial event. Identifying clinical features associated with early recurrence may guide focused management.

Methods: Using logistic regression applied to the data of the Platelet Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) trial, we evaluated what baseline clinical factors predict outcome events occurring within 7 days of randomization. Read More

View Article and Full-Text PDF

Cell line models for drug discovery in PIK3CA-mutated colorectal cancers.

Med Oncol 2022 May 15;39(5):89. Epub 2022 May 15.

Algoma District Cancer Program, Sault Area Hospital, 750 Great Northern Road, Sault Sainte Marie, ON, P6B 0A8, Canada.

Colorectal cancer remains a major cause of cancer-related morbidity and mortality. Metastatic disease is still incurable in most cases. New therapies based on a better understanding of the pathogenesis are needed to improve outcomes. Read More

View Article and Full-Text PDF

Transcription associated cyclin-dependent kinases as therapeutic targets for prostate cancer.

Oncogene 2022 May 14. Epub 2022 May 14.

Imperial Centre for Translational and Experimental Medicine, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, UK.

Transcriptional deregulation has emerged as a hallmark of several cancer types. In metastatic castration-resistant prostate cancer, a stage in which systemic androgen deprivation therapies fail to show clinical benefit, transcriptional addiction to the androgen receptor is maintained in most patients. This has led to increased efforts to find novel therapies that prevent oncogenic transactivation of the androgen receptor. Read More

View Article and Full-Text PDF

Variational autoencoder provides proof of concept that compressing CDT to extremely low-dimensional space retains its ability of distinguishing dementia.

Sci Rep 2022 May 14;12(1):7992. Epub 2022 May 14.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, USA.

The clock drawing test (CDT) is an inexpensive tool to screen for dementia. In this study, we examined if a variational autoencoder (VAE) with only two latent variables can capture and encode clock drawing anomalies from a large dataset of unannotated CDTs (n = 13,580) using self-supervised pre-training and use them to classify dementia CDTs (n = 18) from non-dementia CDTs (n = 20). The model was independently validated using a larger cohort consisting of 41 dementia and 50 non-dementia clocks. Read More

View Article and Full-Text PDF

Distal radial secondary access - A new, minimalistic option during transcatheter aortic valve implantation.

Authors:
Sasko Kedev

Cardiovasc Revasc Med 2022 May 6. Epub 2022 May 6.

Faculty of Medicine, University of S(t) Cyril & Methodius, Interventional Cardiology Department, University Clinic of Cardiology, Mother Theresa, 17, 1000 Skopje, Macedonia. Electronic address:

View Article and Full-Text PDF

Applying an LDL-C threshold-based approach to identify individuals with familial hypercholesterolemia.

J Clin Lipidol 2022 Apr 12. Epub 2022 Apr 12.

Department of Internal Medicine, USA; Division of Cardiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8830, USA; UT Southwestern Medical Center, Dallas, TX, USA. Electronic address:

Background: Familial hypercholesterolemia (FH) remains underdiagnosed and undertreated. The optimal electronic health record (EHR) screening strategy for FH is unclear.

Objective: To evaluate an LDL-C threshold-based approach of identifying patients with FH from the EHR to determine the optimal LDL-C range for FH consideration. Read More

View Article and Full-Text PDF

Effects of metformin and statins on outcomes in men with castration-resistant metastatic prostate cancer: Secondary analysis of COU-AA-301 and COU-AA-302.

Eur J Cancer 2022 May 11. Epub 2022 May 11.

Princess Margaret Cancer Centre, Toronto, Canada; Faculty of Medicine, University of New South Wales, Kensington, Australia; Kinghorn Cancer Centre, St Vincents Hospital, Darlinghurst, Sydney, Australia. Electronic address:

Background: The associations of metformin and statins with overall survival (OS) and prostate specific antigen response rate (PSA-RR) in trials in metastatic castration-resistant prostate cancer remain unclear.

Objective: To determine whether metformin or statins ± abiraterone acetate plus prednisone/prednisolone (AAP) influence OS and PSA-RR.

Design, Setting And Participant: COU-AA-301 and COU-AA-302 patients were stratified by metformin and statin use. Read More

View Article and Full-Text PDF

Sexual Function Following Treatment for Stress Urinary Incontinence With Bulk Injection Therapy and Mid-Urethral Sling Surgery.

J Sex Med 2022 May 11. Epub 2022 May 11.

Amsterdam UMC, University of Amsterdam, Department of Obstetrics and Gynaecology, Amsterdam Reproduction and Development research institute, Amsterdam, The Netherlands; Bergman Clinics, Department of Gynaecology, Bergman Vrouwenzorg, Amsterdam, The Netherlands.

Background: Peri-urethral bulking injections (PBI) gain popularity for the treatment of stress urinary incontinence (SUI), but - in contrast to mid-urethral sling (MUS) surgery - little is known about its impact on sexual function.

Methods: This was a secondary analysis of a prospective cohort study that included patients with moderate to severe SUI undergoing either MUS surgery or PBI with polydimethylsiloxane Urolastic (PDMS-U). The validated Dutch and English version of the 'Pelvic Organ Prolapse and/or Urinary Incontinence Sexual Function Questionnaire - IUGA Revised' (PISQ-IR) was used to assess sexual function at baseline, at 6 and 12 months of follow-up. Read More

View Article and Full-Text PDF

The diagnostic values of red flags in pediatric patients with headache.

Brain Dev 2022 May 11. Epub 2022 May 11.

Department of Pediatrics, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, 93, Joongbudae-ro, Paldal-gu, Suwon-si, Gyeonggi-do 16247, Republic of Korea. Electronic address:

Background: Headache is a common complaint in childhood and adolescence. Differentiating benign primary headaches from ominous secondary headaches is often difficult. Clinicians usually seek red flags to determine the need for neuroimaging. Read More

View Article and Full-Text PDF

Phenotyping exercise limitation of patients with Interstitial Fibrosing Lung Disease: the importance of exercise hemodynamics.

Pulmonology 2022 May 11. Epub 2022 May 11.

University Department of Respiratory Medicine, General Hospital of Thessaloniki "G. Papanikolaou", Aristotle University of Thessaloniki, Thessaloniki, Greece.

Introduction And Objective: Left-heart dysfunction and pulmonary vasculopathy are increasingly recognized as contributing factors of exercise capacity limitation in interstitial fibrosing lung disease (IFLD). Moreover, the clinical significance of exercise pulmonary hypertension (ePH) in pulmonary and cardiac diseases has been documented, representing a risk factor for decreased exercise capacity and survival, progression to resting pulmonary hypertension (PH) and overall clinical worsening. We conducted a prospective study aiming at: (a) assessing the prevalence of PH and ePH in a cohort of 40 functionally limited patients with IFLD, (b) determining the post-capillary (postC) or pre-capillary (preC) etiology of either PH or ePH in this cohort, and (c) examining the correlations between invasively and non-invasively measured exercise variables among hemodynamic groups. Read More

View Article and Full-Text PDF

Emerging mechanisms of telomerase reactivation in cancer.

Trends Cancer 2022 May 11. Epub 2022 May 11.

Integrative and Functional Biology Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi 110025, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; CSIR-Institute of Genomics and Integrative Biology, New Delhi 110025, India; GNR Knowledge Centre for Genome Informatics, CSIR-Institute of Genomics and Integrative Biology, New Delhi 110025, India. Electronic address:

Mutations in the promoter of human telomerase reverse transcriptase (hTERT) result in hyperactivation of hTERT. Notably, all mutations are G>A transitions, frequently found in a wide range of cancer types, and causally associated with cancer progression. Initially, the mutations were understood to reactivate hTERT by generating novel E26 transformation-specific (ETS) binding sites. Read More

View Article and Full-Text PDF

Systematic review and meta-analysis of long-term oncological outcomes of lateral lymph node dissection for metastatic nodes after neoadjuvant chemoradiotherapy in rectal cancer.

Eur J Surg Oncol 2022 Apr 29. Epub 2022 Apr 29.

Colorectal Unit, Department of Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.

Background: Standard Western management of rectal cancers with pre-treatment metastatic lateral lymph nodes (LLNs) is neoadjuvant (chemo)radiotherapy (nCRT) followed by total mesorectal excision (TME). In recent years, there is growing interest in performing an additional lateral lymph node dissection (LLND). The aim of this systematic review and meta-analysis was to investigate long-term oncological outcomes of nCRT followed by TME with or without LLND in patients with pre-treatment metastatic LLNs. Read More

View Article and Full-Text PDF

Serial mediation analysis of treatment-specific processes in two contrasting alcohol treatments.

J Subst Abuse Treat 2022 May 7:108799. Epub 2022 May 7.

Department of Health Sciences, University of York, ARRC Building, Heslington, York YO10 5DD, UK.

Introduction: This study explored whether treatment-specific processes linking therapist behaviors, post-session client ratings, and 3-month proximal outcomes (i.e., end of treatment) can explain 12-month outcomes for two contrasting alcohol treatment conditions with equivalent overall outcomes. Read More

View Article and Full-Text PDF

Effect of imatinib on oral wound healing after extraction: A rare case report.

J Am Dent Assoc 2022 May 11. Epub 2022 May 11.

Background: Proper tissue repair and healing after oral surgery are vital to achieve optimal outcomes. Certain medications may interfere with wound healing, but this debilitating adverse drug reaction is often not reported in the literature. It is unknown whether imatinib (Gleevec; Novartis Pharmaceuticals) interferes with gingival healing after oral surgery. Read More

View Article and Full-Text PDF

Intramedullary abscess secondary to infective endocarditis presenting as longitudinally extensive transverse myelopathy.

Rev Neurol (Paris) 2022 May 11. Epub 2022 May 11.

Service de neurologie-sclérose en plaques, pathologies de la myéline et neuroinflammation, centre de référence des maladies inflammatoires rares du cerveau et de la moelle (MIRCEM), hospices civils de Lyon, hôpital neurologique Pierre-Wertheimer, 69500 Bron, France.

View Article and Full-Text PDF

Multimorbidity in patients living with and beyond cancer: protocol for a scoping review.

BMJ Open 2022 May 13;12(5):e057148. Epub 2022 May 13.

Centre for Primary Care and Public Health, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.

Introduction: The number of people living with and beyond cancer is increasing rapidly. Many of them will experience ongoing physical or psychological sequelae as a result of their original cancer diagnosis or comorbidities arising from risk factors common to cancers and other long-term conditions. This poses the complex problem of managing cancer as a 'chronic' illness along with other existing comorbidities. Read More

View Article and Full-Text PDF

Interventions for the prevention of spontaneous preterm birth: a scoping review of systematic reviews.

BMJ Open 2022 May 13;12(5):e052576. Epub 2022 May 13.

Department of Oncology and Metabolism, The University of Sheffield, Sheffield, UK.

Background: Globally, 11% of babies are born preterm each year. Preterm birth (PTB) is a leading cause of neonatal death and under-five mortality and morbidity, with lifelong sequelae in those who survive. PTB disproportionately impacts low/middle-income countries (LMICs) where the burden is highest. Read More

View Article and Full-Text PDF

Systematic review protocol of the effectiveness of HIV prevention interventions for reducing risky sexual behaviour among youth globally.

BMJ Open 2022 May 13;12(5):e056929. Epub 2022 May 13.

Global Health Nursing, Department of Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

Introduction: Human immunodeficiency virus (HIV) prevention interventions focused at reducing risky sexual behaviours are an important strategy for preventing HIV infection among youth (15-24 years) who continue to be vulnerable to the disease. This systematic review aims to synthesise current global evidence on the effectiveness of HIV prevention interventions for reducing risky sexual behaviour among youth in the last decade.

Methods And Analysis: MEDLINE/PubMed, EMBASE, PsychINFO, ProQuest Central, CINAHL and Web of Science databases, ClinicalTrials. Read More

View Article and Full-Text PDF

Thoracic spinal anaesthesia for abdominal surgery in a humanitarian military field hospital: a prospective observational study.

BMJ Mil Health 2022 May 13. Epub 2022 May 13.

Anesthesiology and Intensive Care, Cadi Ayyad University Faculty of Medicine and Pharmacy of Marrakech, Marrakech, Morocco.

Background: Providing safe and effective anaesthesia in the context of humanitarian medicine is always a challenging situation. Spinal anaesthesia, and in particular its thoracic approach, represents a promising technique for such a limited-resource environment. This prospective observational study investigated the feasibility of thoracic spinal anaesthesia (TSA) for abdominal surgery in a field-deployed military hospital. Read More

View Article and Full-Text PDF

Microaggressions: Black students' experiences - A qualitative study.

J Prof Nurs 2022 May-Jun;40:73-78. Epub 2022 Mar 17.

MGH Institute of Health Professions, School of Nursing, Charlestown Navy Yard, 36 1st Avenue, Boston, MA 02129, United States of America.

Background: Studies in other disciplines have shown that Black college students experience microaggressions on campus. This affects campus learning climates, posing a risk to students' success.

Purpose: The purpose of this secondary analysis is to describe Black nursing students' experiences with microaggression at a predominantly white institution. Read More

View Article and Full-Text PDF

Rheumatoid Arthritis, Statin Indication and Lipid Goals: Analysis According to Different Recommendations.

Reumatol Clin (Engl Ed) 2022 May;18(5):266-272

Servicio de Reumatología, Hospital Italiano de Buenos Aires, Tte. Gral. Juan Domingo Perón 4190, C1199ABB Ciudad Autónoma de Buenos Aires, Argentina.

Background: Different strategies have been proposed for the cardiovascular risk management of patients with rheumatoid arthritis (RA).

Objectives: (1) To estimate the cardiovascular risk by different strategies in RA patients, analyzing which proportion of patients would be candidates to receive statin therapy; (2) to identify how many patients meet the recommended lipid goals.

Methods: A cross-sectional study was performed from a secondary database. Read More

View Article and Full-Text PDF

Participant-Directed Intervention Tailoring Is Associated With Improvements in Glycemic Control for South Asian Adults With Type 2 Diabetes.

Can J Diabetes 2022 Apr 27;46(3):287-293. Epub 2021 Nov 27.

Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Objectives: Our aim was to determine the impact of a 3-month diabetes self-management education and support (DSME/DSMS) intervention involving both professional and peer support on glycemic control and diabetes distress in South Asian adults with type 2 diabetes (T2D) living in Metro Vancouver.

Methods: We recruited 114 South Asian adults with T2D for a study conducted across 7 sites in Metro Vancouver. A previous DSME/DSMS intervention was modified using participant feedback. Read More

View Article and Full-Text PDF