5,568 results match your criteria Metastatic Neoplasms to the Oral Cavity


Metastatic prostate cancer presenting as trigeminal nerve paresthesia in the mandible.

Gen Dent 2021 May-Jun;69(3):58-60

Metastatic disease to the oral cavity is rare and often presents with ambiguous symptoms and subtle or no radiographic changes. These factors make diagnosis challenging. This article describes a case of metastatic prostate cancer to the mandible that presented as altered sensation to the gingiva, lips, and chin without radiographic evidence of pathosis noted on standard dental imaging. Read More

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[Preliminary clinical study on the effect of metformin on prognosis of patients with oral squamous cell carcinoma after surgical treatment].

Shanghai Kou Qiang Yi Xue 2021 Feb;30(1):61-65

Centre of Stomatology, Xiangya Hospital, Central South University. Changsha 410008, China.

Purpose: To investigate the effect of metformin on the prognosis of patients with oral squamous cell carcinoma after surgical treatment.

Methods: Three hundred and forty-six patients with oral squamous cell carcinoma after operation in Xiangya Hospital of Central South University from October 2015 to October 2016 were selected and divided into experimental group and control group. In the experimental group, 71 patients with oral squamous cell carcinoma received metformin after surgery. Read More

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February 2021

Squamous cell carcinoma of the tongue with cardiac metastasis on 18F-FDG PET/CT: A case report and literature review.

Medicine (Baltimore) 2021 Apr;100(15):e25529

Department of Nuclear Medicine, Centre Hospitalier Universitaire Bichat.

Introduction: The most common malignancies metastasizing to the heart are cancers of the lung, breast, mesothelioma, melanoma, leukemia, and lymphoma. Cardiac metastasis from a tongue cancer is a rare finding and only a few cases have been reported previously in the literature. In this case report and literature review, we discuss the main clinical features of patients with cardiac metastases secondary to a tongue cancer and imaging modalities performed, especially the 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). Read More

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Tongue: the unusual site in malignant pleural mesothelioma.

BMJ Case Rep 2021 Apr 12;14(4). Epub 2021 Apr 12.

The Cancer Centre, Oncology, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham, Birmingham, UK

Malignant mesotheliomas (MMs) are malignancies of the mesothelium, with primary deposits originating in the pleura, peritoneum, pericardium and the tunica vaginalis (ie, testicular). Metastatic spread is commonly reported to affect the liver, adrenal glands, kidney and contralateral lung (in cases of malignant pleural mesothelioma). Metastases to distant sites are uncommon. Read More

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Incidental finding of metastatic malignancy involving the sphenoid sinus on a cone-beam computed tomographic scan: A case report.

Imaging Sci Dent 2021 Mar 28;51(1):87-90. Epub 2021 Jan 28.

Department of Oral and Maxillofacial Pathology, Radiology and Medicine, New York University College of Dentistry, New York, NY, USA.

The increased use of cone-beam computed tomographic (CBCT) scans has made it increasingly necessary to evaluate incidental findings on CBCT scans. This report describes the case of a 66-year-old female patient who presented to the Department of Oral and Maxillofacial Pathology, Radiology and Medicine at the College of Dentistry of the author's institution and underwent a CBCT scan for maxillary alveolar process implant planning. Upon evaluation of the CBCT scan, a radiopaque (soft tissue attenuation) mass in the left superior aspect of the nasal cavity and left locule of the sphenoid sinus with opacification of the left locule of the sphenoid sinus was incidentally noted. Read More

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Value of Panendoscopy in the Identification of Synchronous Malignancies in Patients Suffering from Oral Squamous Cell Carcinoma Without Clinical Signs of a Second Primary Tumor.

Anticancer Res 2021 Apr;41(4):2039-2044

Department of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background/aim: The aim of the present study was to assess the value of panendoscopy of the upper aero-digestive tract in the identification of synchronous tumors in OSCC patients without clinical signs of a second primary tumor.

Patients And Methods: In this retrospective study, patients diagnosed with a primary OSCC who received surgical therapy between January 1, 2012 and December 31, 2017 were included. Participants must have undergone panendoscopy during the staging process. Read More

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Symptom Burden in Patients Treated With Palliative Radiotherapy Before and During the COVID-19 Pandemic.

Anticancer Res 2021 Apr;41(4):1971-1974

Department of Oncology and Palliative Medicine, Nordland Hospital, Bodø, Norway.

Background/aim: Oncological care has faced several challenges during the COVID-19 pandemic, e.g. treatment delay and worsening symptoms. Read More

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Clinicopathological features of incidental parotid lesions.

Head Face Med 2021 Mar 23;17(1):10. Epub 2021 Mar 23.

Michael E. DeBakey VA Medical Center, 2002 Holcombe Blvd, 77030, Houston, Texas, USA.

Background: The purpose of this study is to determine the histopathological spectrum and risk of primary malignancy of asymptomatic parotid lesions incidentally discovered on cross-sectional imaging.

Methods: Over a 10-year period, 154 patients underwent 163 ultrasound-guided parotid lesion biopsies at our institution. This retrospective chart review included 89 lesions in 87 patients with asymptomatic parotid lesions discovered on cross-sectional imaging studies performed for unrelated clinical indications. Read More

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Pancytokeratin immunostained tumor buds and cytoplasmic pseudofragments are reliable early predictive variables for regional lymph node metastatic risk assessment of oral squamous cell carcinoma.

Indian J Dent Res 2020 Nov-Dec;31(6):904-910

Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bangalore, Karnataka, India.

Context: The 5-year survival rate in patients with cervical lymph node metastasis is reported to be 20-36% post surgery as compared to 63-86% in patients without nodal involvement. This necessitates assessing the metastatic potential of OSCC patients.

Objectives: To evaluate the role of Pancytokeratin immunostained tumour buds and cytoplasmic pseudofragments with other histopathological and immunohistochemical variables in predicting metastatic risk of Oral Squamous Cell Carcinoma (OSCC). Read More

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Tribulus terrestris fruit extract inhibits autophagic flux to diminish cell proliferation and metastatic characteristics of oral cancer cells.

Environ Toxicol 2021 Jun 10;36(6):1173-1180. Epub 2021 Mar 10.

Oral and Maxillofacial Surgery Section, Chi Mei Medical Center, Tainan, Taiwan.

Elevated autophagy is highly associated with cancer development and progression. Fruit extracts of several plants inhibit activity of autophagy-related protease ATG4B and autophagy activity in colorectal cancer cells. However, the effects of these plant extracts in oral cancer cells remain unclear. Read More

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Rare submandibular gland metastasis of hepatocellular carcinoma: case report and review of the literature.

J Int Med Res 2021 Mar;49(3):300060521997592

Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

Hepatocellular carcinoma (HCC), the most common primary hepatic tumor, metastasizes in more than 50% of cases. However, metastasis of HCC to the submandibular glands is very rare. HCC rarely metastasizes to the salivary glands; only six cases of metastasis to the parotid gland have been reported in the English-language literature. Read More

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Hypoxic miRNAs expression are different between primary and metastatic melanoma cells.

Gene 2021 May 9;782:145552. Epub 2021 Mar 9.

Clinical Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University, Kagoshima 890-0065, Japan; Veterinary Teaching Hospital, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan; Clinical Veterinary Science, Joint Graduate School of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan. Electronic address:

MicroRNAs (miRNAs) can rapidly respond to cellular stresses, such as hypoxia. This immediate miRNA response regulates numerous genes and influences multiple signaling pathways. Therefore, identifying hypoxia-regulated miRNAs (HRMs) is important in canine oral melanoma (COM) to investigate their clinical significance. Read More

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Tobacco Awareness with Socioeconomic Status and Pictorial Warning in Tobacco Cessation: An Exploratory Institutional Survey in a Semi-urban Population.

J Contemp Dent Pract 2020 Oct 1;21(10):1122-1129. Epub 2020 Oct 1.

Department of Oral Medicine and Radiology, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India.

Aim: To explore the impact of socioeconomic status (SES) and/on the awareness of ill effects of tobacco on oral and general health and to evaluate the effectiveness of pictorial warning on tobacco cessation in a semi-urban population of South Chennai.

Materials And Methods: This cross-sectional survey for 1 week was conducted using a two-stage sampling design, with a sample size of 300. New op patients constitute the first sampling design, and patients with history of any form of tobacco constituted second sampling design for the second part of the study. Read More

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October 2020

Silencing DNA Polymerase β Induces Aneuploidy as a Biomarker of Poor Prognosis in Oral Squamous Cell Cancer.

Int J Mol Sci 2021 Feb 27;22(5). Epub 2021 Feb 27.

Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Most patients with oral squamous cell cancer (OSCC) have a locally advanced stage at diagnosis. The treatment strategies are diverse, including surgery, radiotherapy and chemotherapy. Despite multimodality treatment, the response rate is unsatisfactory. Read More

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February 2021

Central neck lymph node metastasis in oral squamous cell carcinoma at the floor of mouth.

BMC Cancer 2021 Mar 5;21(1):225. Epub 2021 Mar 5.

Department of General Dentistry, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou, China.

Background: Our goal was to analyze the incidence of level VI metastasis in previously untreated oral squamous cell carcinoma (SCC) patients and their clinicopathological and prognostic characteristics.

Methods: Oral SCC patients with level VI metastasis were retrospectively enrolled, and their demographic and pathologic features as well as their survival data were descriptively analyzed.

Results: A total of 13 cases from 1875 patients were included, all patients had SCC at the floor of mouth (SCCFOM). Read More

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FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma.

Int J Oral Sci 2021 03 1;13(1). Epub 2021 Mar 1.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management & West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and with 354 864 new cases each year. Cancer metastasis, recurrence, and drug resistance are the main causes to cripples and deaths of OSCC patients. As potent growth factors, fibroblast growth factors (FGFs) are frequently susceptible to being hijacked by cancer cells. Read More

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The potential of somatostatin receptor 2 as a novel therapeutic target in salivary gland malignant tumors.

J Cancer Res Clin Oncol 2021 May 17;147(5):1335-1340. Epub 2021 Feb 17.

Department of Otolaryngology, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel.

Background: Treatment regimens for patients with metastatic or recurrent post-radiation, locoregional, unresectable salivary cancer are limited. An inverse correlation between somatostatin receptor 2 (SSTR2) and the proliferating marker Ki-67 in neuroendocrine tumors has enabled a treatment plan for metastatic disease, utilizing peptide receptor radionuclide therapy. Interestingly, healthy salivary glands express high levels of SSTR2. Read More

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Precise locating and cutting of the bone lid with a digital template during the treatment of large mandibular cysts: A case series study.

J Craniomaxillofac Surg 2021 May 5;49(5):358-361. Epub 2021 Feb 5.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address:

The aim of the study was to investigate the efficacy and safety of a digital template in the bone lid technique during enucleation of large mandibular cysts. Six patients were enrolled in this study. Patients' preoperative CT data were collected to design and produce the digital templates. Read More

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A systematic review of the primary squamous cell carcinoma of the external auditory canal: survival outcome based on T-staging and proposal of a new classification.

J Laryngol Otol 2021 Feb 11;135(2):96-103. Epub 2021 Feb 11.

ENT Service, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Objective: This study aimed to provide a systematic review on survival outcome based on Pittsburgh T-staging for patients with primary external auditory canal squamous cell carcinoma.

Method: This study was a systematic review in compliance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines performed until January 2018; pertinent studies were screened. Quality of evidence was assessed using the grading of recommendation, assessment, development and evaluation working group system. Read More

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February 2021

[Clinicopathological analysis of mucosa associated lymphoid tissue lymphoma secondary to Sjögren' s syndrome in salivary gland].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Nov;53(1):40-45

Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To analyze the clinicopathological characteristics of mucosa associated lymphoid tissue (MALT) lymphoma secondary to Sjögren' s syndrome (SS) (SS-MALT lymphoma) in salivary gland and to explore the value of the combined application of histopathological morphology, protein expression and molecular phenotype in pathological diagnosis and prognostic evaluation of SS-MALT lymphoma.

Methods: Sixteen patients with SS-MALT lymphoma were collected from 260 patients who were diagnosed with SS in Peking University School and Hospital of Stomatology from January 1997 to December 2016. Twelve patients with non-MALT lymphoma secondary to SS (non-SS-MALT lymphoma) in salivary gland were selected as controls. Read More

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November 2020

[A Consideration for the Surgical Approach in Laparoscopic Total Pelvic Exenteration after Radiotherapy : A Case Report].

Hinyokika Kiyo 2021 Jan;67(1):31-35

The Department of Urology, Japan Red Cross Wakayama Medical Center.

A 66-year-old woman underwent concurrent chemoradiotherapy (CCRT) for stage IIA cervical cancer. However, two recurrent masses were detected at the vaginal stump 6 years after CCRT, and we performed laparoscopic total pelvic exenteration to obtain a complete cure. Because the terminal ileum appeared white secondary to the effects of radiotherapy, we constructed an ileal conduit using the ileum, approximately 40 cm toward the mouth from the ileocecum. Read More

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January 2021

Effect of Honey-Lemon Spray Versus Benzydamine Hydrochloride Spray on Radiation-Induced Acute Oral Mucositis in Head and Neck Cancer Patients: A Pilot, Randomized, Double-Blind, Active-Controlled Clinical Trial.

J Altern Complement Med 2021 Mar 28;27(3):255-262. Epub 2021 Jan 28.

Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Oral mucositis (OM) is the most prevalent side effect in patients with head and neck cancer (HNC). It causes an obvious decrease in quality of life (QoL) in these patients, so different medications have been recommended for OM, however, without optimal response. This randomized trial aimed to assess the effects of a honey-lemon spray compared with benzydamine hydrochloride in prevention of radiation-induced OM in patients with HNC. Read More

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Electrocoagulation for liver metastases.

Cochrane Database Syst Rev 2021 01 28;1:CD009497. Epub 2021 Jan 28.

Chair of Epidemiology and Preventive Medicine, Department of Hygiene and Dietetics, Jagiellonian University Medical College, Krakow, Poland.

Background: Primary liver tumours and liver metastases from colorectal carcinoma are two of the most common malignant tumours to affect the liver. The liver is second only to the lymph nodes as the most common site for metastatic disease. More than half of the people with metastatic liver disease will die from metastatic complications. Read More

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January 2021

Eficacy of Cryotherapy in the Prevention of Oral Mucosistis in Adult Patients with Chemotherapy.

Int J Environ Res Public Health 2021 01 23;18(3). Epub 2021 Jan 23.

Department of Nursing, Physiotherapy and Occupational Therapy, Facultad de Enfermería, Universidad de Castilla-La Mancha, Campus Univesitario s/n, 02071 Albacete, Spain.

Oral mucositis (OM) is a common side effect of cancer therapies. It causes ulcerative, painful lesions in the oral cavity that can provoke malnutrition, increased risk of infection, longer hospital stays, and seriously affect the quality of life. Cooling the mucosa with oral cryotherapy (OC) during and/or after chemotherapy is the most accessible and tolerable intervention available. Read More

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January 2021

Numb chin syndrome in sickle cell disease: a case series of Jamaican patients.

Ann Hematol 2021 Apr 22;100(4):913-919. Epub 2021 Jan 22.

Caribbean Institute for Health Research, Sickle Cell Unit, The University of the West Indies, Mona Campus, Kingston 7, Jamaica.

Numb chin syndrome is an uncommon presentation that has been reported as secondary to metastatic disease, trauma, and infections of the maxilla, mandible, or oral cavity. The hypoesthesia, paraesthesia, or pain are a result of injury to the inferior alveolar nerve, which is particularly vulnerable as it exits the mandible through the mandibular foramen as the mental nerve. In persons with sickle cell disease, it has been reported as a manifestation of mandibular vaso-occlusive crisis. Read More

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[Recurrent Esophageal Cancer with Metastatic Lymph Node Penetrating in the Reconstructed Gastric Tube-A Case Report].

Gan To Kagaku Ryoho 2020 Dec;47(13):1902-1904

Dept. of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine.

A 60-year-old man underwent thoracoscopic subtotal esophagectomy and posterior mediastinal gastric tube reconstruction after neoadjuvant chemotherapy. One year and 8 months postoperatively, recurrence was observed in the abdominal lymph nodes around the celiac artery and abdominal aorta. Chemoradiotherapy was initiated, followed by chemotherapy. Read More

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December 2020

Solitary adrenal metastasis from salivary duct carcinoma of the parotid gland successfully treated by surgery: A case report.

Medicine (Baltimore) 2021 Jan;100(2):e24011

Department of Pathology.

Rationale: Salivary duct carcinoma (SDC) is a rare and highly aggressive cancer with a poor prognosis. SDC demonstrates a potential for invasive growth with early regional and distant metastasis to organs, such as bone, lung, liver, and brain. Because, adrenal gland metastasis from SDC is rare, its treatment options are not well established. Read More

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January 2021

Oral exposure to environmental cyanobacteria toxins: Implications for cancer risk.

Environ Int 2021 03 19;148:106381. Epub 2021 Jan 19.

University of Guam Cancer Research Center, Mangilao, GU, United States. Electronic address:

Background: Areca nut/betel quid (AN/BQ) chewing, a prevalent practice in parts of the Pacific and Asia, is an independent cause of cancers of the oral cavity and esophagus and may be linked to liver cancer. The mechanisms of AN/BQ-associated carcinogenesis are unclear. In a Guam population, we previously demonstrated that AN/BQ chewing alters the oral bacterial microbiome including in chewers with oral premalignant lesions. Read More

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CD4 and CD8 T cells in sentinel nodes exhibit distinct pattern of PD-1, CD69, and HLA-DR expression compared to tumor tissue in oral squamous cell carcinoma.

Cancer Sci 2021 Mar 15;112(3):1048-1059. Epub 2021 Feb 15.

Division of ENT Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

Anticancer immunotherapies have revolutionized cancer management, yet the effect of systemic anti-programmed cell death protein 1 (PD-1) treatment is predominantly studied in tumor-infiltrating lymphocytes (TILs). Its impact on PD-1 expressing cells in tumor-draining lymph nodes (TDLNs) is not well understood and yet to be explored. Thus, further research aiming for better understanding of the PD-1 pathway not only in tumor tissue but also in TDLNs is warranted. Read More

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Retromolar intubation for severe trismus: a less invasive alternative to tracheostomy and submental intubation.

BMJ Case Rep 2021 Jan 18;14(1). Epub 2021 Jan 18.

Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, Oregon, USA.

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January 2021