5,002 results match your criteria Metastatic Neoplasms to the Oral Cavity


Time intervals from first symptom to diagnosis for head and neck cancers: An analysis of linked patient reports and medical records from the UK.

Cancer Epidemiol 2019 Jan 19;59:37-45. Epub 2019 Jan 19.

Hull York Medical School, Allam Medical Building, University of Hull, Hull, HU6 7RX, United Kingdom. Electronic address:

Background: England has significantly higher mortality risks due to Head and Neck Cancer (HNC) compared with other European countries. Early diagnosis is important as it is likely to increase early-stage diagnosis and improve survival and better quality of life. This study sought to improve understanding of the intervals from first symptom recognition to diagnosis for HNC and investigate associations between patient-reported symptoms and socio-demographic factors. Read More

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http://dx.doi.org/10.1016/j.canep.2019.01.008DOI Listing
January 2019
2 Reads

Improved survival among oral cancer patients: findings from a retrospective study at a tertiary care cancer centre in rural Kerala, India.

World J Surg Oncol 2019 Jan 11;17(1):15. Epub 2019 Jan 11.

Department of Surgical Oncology, Malabar Cancer Centre, Thalassery, Kerala, 670 103, India.

Background: Oral cancer is very common in India. The reported 5-year survival of such patients is around 50% after treatment with surgery and radiotherapy, much lower than most of the developed countries.

Methods: A retrospective study of a prospective database of oral cancer patients undergoing surgery from June 2009 to June 2013 was conducted. Read More

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http://dx.doi.org/10.1186/s12957-018-1550-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330462PMC
January 2019

Intraperitoneal delivery of NanoOlaparib for disseminated late-stage cancer treatment.

Int J Nanomedicine 2018 29;13:8063-8074. Epub 2018 Nov 29.

Department of Bioengineering, Northeastern University, Boston, MA, USA,

Background: PARP inhibitors, such as Olaparib, have advanced the treatment of ovarian cancer by providing patients with an effective and molecularly-targeted maintenance therapy. However, all orally-administered drugs, including Olaparib, must undergo first-pass metabolism. In contrast, a nanoparticle delivery system has the advantage of administering Olaparib directly into the peritoneal cavity for local treatment. Read More

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https://www.dovepress.com/intraperitoneal-delivery-of-nanool
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http://dx.doi.org/10.2147/IJN.S186881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278886PMC
January 2019
8 Reads

Contribution of Promoter Genotypes to Oral Cancer Susceptibility, Recurrence and Metastasis in Taiwan.

Anticancer Res 2018 Dec;38(12):6821-6826

Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Aim: Metalloproteinase 2 (MMP2) is a multi-functional protein which has been shown to be up-regulated in patients with oral cancer, especially those with lymph node metastasis. However, the association of MMP2 genotype with oral cancer risk or metastatic behavior is unknown. This study aimed to evaluate the role of MMP2 promoter 1306 and -735 genotypes in the risk of oral cancer and metastasis. Read More

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http://dx.doi.org/10.21873/anticanres.13055DOI Listing
December 2018

Acinic cell carcinoma of parotid gland with cavernous sinus metastasis: A case report.

J Cancer Res Ther 2018 Oct-Dec;14(6):1428-1430

Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.

Acinic cell carcinoma (AciCC) is a low-grade malignancy which rarely metastasizes to bone or cavernous sinuses. A 62-year-old male patient, previously treated for AciCC of right parotid with surgery and local radiotherapy, presented 10 years later with progressive visual impairment and restriction of ocular movements. Magnetic resonance imaging of the head and orbit showed an expansile lobulated mass with heterogeneous signal intensity in bilateral cavernous sinus with encasement of the internal carotid artery on both sides. Read More

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http://dx.doi.org/10.4103/0973-1482.192850DOI Listing
February 2019
9 Reads

Tongue base mucosectomy for carcinoma of unknown primary using endoscopic electrocautery: rationale for wider implementation of an institutionally restricted technique.

J Laryngol Otol 2018 Dec 20;132(12):1138-1142. Epub 2018 Nov 20.

Department of ENT, Head and Neck Surgery,Royal Sussex County Hospital,Brighton, and Head and Neck Unit,Queen Victoria Hospital,East Grinstead,UK.

Background: Cervical metastasis from an unknown primary site invariably results in pan-mucosal irradiation if a primary tumour is not identified. Transoral robotic and laser-assisted mucosectomy are valid techniques to increase diagnostic rates, but these remain restricted to certain centres. This paper describes, in detail, a technique in which mucosectomy is performed via endoscopic electrocautery. Read More

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http://dx.doi.org/10.1017/S0022215118002062DOI Listing
December 2018
17 Reads

Are elderly patients presenting with squamous cell carcinoma of the oral cavity given the appropriate treatment?

Surg Oncol 2018 Dec 2;27(4):715-721. Epub 2018 May 2.

Universitary Hospital Pitié Salpêtrière, AP-HP, Department of Maxillo-facial Surgery, 47-83 boulevard de l'hôpital, 75 651 Paris Cedex 13, France; Pierre & Marie Curie University, 4 Place Jussieu 75252 Paris Cedex 05, France.

Objectives: There is no consensus for the specific management of elderly patients presenting with oral cavity squamous cell carcinomas (OC SCC). We report our findings in the treatment of primary OC SCC, for patients of 70 years of age or more, in a French university hospital center.

Patients And Methods: One hundred and twenty five patients diagnosed between 2000 and 2010, were included retrospectively. Read More

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http://dx.doi.org/10.1016/j.suronc.2018.04.005DOI Listing
December 2018
3 Reads

Results of a randomized controlled trial of level IIb preserving neck dissection in clinically node-negative squamous carcinoma of the oral cavity.

World J Surg Oncol 2018 Nov 8;16(1):219. Epub 2018 Nov 8.

Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005, India.

Background: The lymphatic spread from the cancers of the oral cavity follows an orderly progression and involvement of lower nodes without involvement of upper nodes and skip metastasis is rare. Selective neck dissections are increasingly being performed for node-positive patients; however, in node-negative patients the options of wait and watch, prophylactic radiotherapy, and prophylactic elective node dissections are debated. Quality of life and shoulder functions are important to choose the appropriate therapeutic modality. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-018-1
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http://dx.doi.org/10.1186/s12957-018-1518-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225726PMC
November 2018
10 Reads

[A Case of Long-Term Survival with Multidisciplinary Treatment in Unresectable Advanced Gastric Cancer Found with Ovarian Tumor].

Gan To Kagaku Ryoho 2018 Oct;45(10):1489-1491

Dept. of Surgery, Yokohama City University.

Although chemotherapy is the standard treatment for unresectable advanced gastric cancer, its prognosis is poor and the median survival time is only around 10 months. With some literature consideration, we report that ovarian metastasis triggered the diagnosis of unresectable advanced gastric cancer with long-term survival through multidisciplinary treatment. This is the case of a 69-year-old woman, who was diagnosed with ovarian tumor and underwent right extracorporectomy and omentum resection in 2011. Read More

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October 2018
2 Reads

Unique Photochemo-Immuno-Nanoplatform against Orthotopic Xenograft Oral Cancer and Metastatic Syngeneic Breast Cancer.

Nano Lett 2018 11 26;18(11):7092-7103. Epub 2018 Oct 26.

Department of Biochemistry and Molecular Medicine, UC Davis NCI-designated Comprehensive Cancer Center , University of California Davis , Sacramento , California 95817 , United States.

Sophisticated self-assembly may endow materials with a variety of unique functions that are highly desirable for therapeutic nanoplatform. Herein, we report the coassembly of two structurally defined telodendrimers, each comprised of hydrophilic linear PEG and hydrophobic cholic acid cluster as a basic amphiphilic molecular subunit. One telodendrimer has four added indocyanine green derivatives, leading to excellent photothermal properties; the other telodendrimer has four sulfhydryl groups designed for efficient intersubunit cross-linking, contributing to superior stability during circulation. Read More

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http://pubs.acs.org/doi/10.1021/acs.nanolett.8b03096
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http://dx.doi.org/10.1021/acs.nanolett.8b03096DOI Listing
November 2018
10 Reads

HLA-G Expression is Associated with an Unfavorable Prognosis of Oral Squamous Cell Carcinoma

Asian Pac J Cancer Prev 2018 Sep 26;19(9):2527-2533. Epub 2018 Sep 26.

Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Email:

Background: HLA-G, a major histocompatibility complex of non-classical class Ib, plays a key role in the development of the primary tumors to metastatic stages. The aim of this study was to investigate HLA-G expression in oral squamous cell carcinomas and its relationship with clinicopathological factors. Methods: After immunohistochemical staining for HLA-G with 63 formalin fixed and paraffin embedded blocks (33 oral squamous cell carcinoma and 30 normal oral mucosa samples), staining intensity, percentage of stained cells and final immunoreactivity score were evaluated, along with other variables. Read More

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http://dx.doi.org/10.22034/APJCP.2018.19.9.2527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249475PMC
September 2018
1 Read
1.500 Impact Factor

Impact of enhanced recovery after surgery (ERAS) protocol on gastrointestinal function in gynecologic oncology patients undergoing laparotomy.

Gynecol Oncol 2018 11 21;151(2):282-286. Epub 2018 Sep 21.

Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL, United States.

Objective: To evaluate the impact of enhanced recovery after surgery (ERAS) on postoperative gastrointestinal function in gynecologic oncology patients.

Methods: This retrospective cohort study compared gynecology oncology patients undergoing non-emergent laparotomy from 10/2016 to 6/2017 managed on an ERAS protocol to a control cohort from the year prior to ERAS implementation. Major changes to postoperative care after ERAS implementation included multimodal analgesia, early feeding, goal-directed fluid resuscitation, and early ambulation. Read More

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http://dx.doi.org/10.1016/j.ygyno.2018.09.009DOI Listing
November 2018
4 Reads

Preoperative diagnostic of parotid gland neoplasms: fine-needle aspiration cytology or core needle biopsy?

Eur Arch Otorhinolaryngol 2018 Nov 20;275(11):2609-2613. Epub 2018 Sep 20.

International Head and Neck Scientific Group, Padua, Italy.

A preoperative cytologic or histologic diagnosis of parotid gland neoplasms is mandatory to decide which surgical procedure would be appropriate. Open biopsies are contraindicated because of the risk of recurrence secondary to tumour cell seeding; furthermore a subsequent curative parotid surgery can be complicated by a previous open biopsy. While fine-needle aspiration cytology (FNAC) was the only preoperative diagnostic procedure to distinguish benign versus malignant neoplasms over the past decades, core needle biopsy (CNB) has been increasingly used over the last few years. Read More

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http://dx.doi.org/10.1007/s00405-018-5131-0DOI Listing
November 2018

Targeted next-generation sequencing of 50 cancer-related genes in Japanese patients with oral squamous cell carcinoma.

Tumour Biol 2018 Sep;40(9):1010428318800180

1 Department of Medical Genome Sciences, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo, Japan.

Somatic mutation analysis is a standard of practice for human cancers to identify therapeutic sensitization and resistance mutations. We performed a multigene sequencing screen to explore mutational hotspots in cancer-related genes using a semiconductor-based sequencer. DNA from oral squamous cell carcinoma samples was used as a template to amplify 207 regions from 50 cancer-related genes. Read More

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http://dx.doi.org/10.1177/1010428318800180DOI Listing
September 2018
8 Reads

[Clinicopathologic features and prognosis of adenoid cystic carcinoma of external auditory meatus].

Zhonghua Bing Li Xue Za Zhi 2018 Sep;47(9):691-695

Department of Pathology, PLA General Hospotal, Beijing 100853, China.

To investigate clinicopathologic features and prognosis of adenoid cystic carcinoma (ACC) involving external auditory meatus. The clinical presentation and follow-up data of 63 patients with ACC of external auditory canal were collected from January 2006 to February 2017 at PLA General Hospital and Hainan Branch of PLA General Hospital. The clinicopathologic features and prognostic factors of external auditory canal ACC were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.09.008DOI Listing
September 2018
1 Read

Immunohistochemical expression of TWIST in oral squamous cell carcinoma and its correlation with clinicopathologic factors.

J Cancer Res Ther 2018 Jul-Sep;14(5):964-969

Students Research Committee, Babol University of Medical Sciences, Babol University of Medical Sciences, Babol, IR Iran.

Background And Objectives: TWIST is a transcription factor that plays a key role in the development of primary tumor to metastatic stage of cancer. It is an inhibitor of E-cadherin in epithelial-to-mesenchymal transformation process (epithelial-mesenchymal transition). Few studies are available on the use of TWIST as a goal in molecular-targeted therapy. Read More

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http://dx.doi.org/10.4103/0973-1482.224350DOI Listing
November 2018
1 Read

Prognostic factors in parotid cancers: Clinicopathological and treatment factors influencing outcomes.

Indian J Cancer 2018 Jan-Mar;55(1):98-104

Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Background: Parotid cancers are uncommon and have a relatively long natural history. Determination of prognostic factors affecting the outcome is difficult.

Materials And Methods: The primary objective was to determine the demographic, clinical, histopathology and treatment-related factors affecting overall survival (OS) in parotid cancers. Read More

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http://dx.doi.org/10.4103/ijc.IJC_503_17DOI Listing
November 2018
14 Reads

Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma.

Oncol Rep 2018 Nov 22;40(5):2487-2496. Epub 2018 Aug 22.

Division of Oral Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951‑8514, Japan.

Transcription factor SRY‑box 9 (SOX9) is a key regulator of chondrocyte differentiation and sex determination, and it is also involved in the progression of various types of human cancer. However, its putative association with oral squamous cell carcinoma (OSCC) remains elusive. The aim of the present study was to investigate the expression profiles of SOX9 in various oral epithelial lesions, including OSCC. Read More

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http://dx.doi.org/10.3892/or.2018.6665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151877PMC
November 2018
13 Reads

Mediastinal metastasectomy from a primary germ cell testicular tumour resulting in occult thoracic duct injury and chylothorax.

BMJ Case Rep 2018 Aug 17;2018. Epub 2018 Aug 17.

Cardiothoracic Surgery, Fiona Stanley Hospital, Perth, Western Australia, Australia.

A 22-year-old man underwent mediastinal metastasectomy for a testicular germ cell tumour via median sternotomy. Intraoperatively, the tumour was massive, measuring 88 mm in anterior-posterior (AP) diameter. It was densely adherent to the trachea and aggressive debulking resulted in tracheal injury. Read More

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http://dx.doi.org/10.1136/bcr-2018-225715DOI Listing
August 2018
10 Reads

Efficacy and safety of nimotuzumab in unresectable, recurrent, and/or metastatic squamous cell carcinoma of the head and neck: A hospital-based retrospective evidence.

South Asian J Cancer 2018 Jul-Sep;7(3):188-192

Medical affairs, Biocon Ltd, Bengaluru, Karnataka, India.

Context: Role of nimotuzumab in locally advanced head and neck cancer (HNC) is well established in India; however, no clinical evidence is available for its role in recurrent and/or metastatic HNC.

Aims: The aim of this study is to evaluate the efficacy and safety of nimotuzumab when added to standard treatment in unresectable, recurrent, and metastatic squamous cell carcinoma of the head and neck (SCCHN).

Settings And Design: Hospital records of 14 patients diagnosed with recurrent and/or metastatic HNC with histologically confirmed squamous cell carcinoma and being treated with nimotuzumab along with standard treatments from December 2010 to December 2016 were retrospectively evaluated. Read More

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http://dx.doi.org/10.4103/sajc.sajc_87_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069342PMC
August 2018
2 Reads

Preventive measures in oral cancer: An overview.

Biomed Pharmacother 2018 Nov 3;107:72-80. Epub 2018 Aug 3.

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, India. Electronic address:

Worldwide oral cancer is creating an alarming situation and it's a matter of global concern as it is the 11th most common carcinoma around the globe. After cardiovascular ailments, cancer is the next biggest killer. Approximately 90% of the total oral malignancies are squamous cell carcinomas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183363
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http://dx.doi.org/10.1016/j.biopha.2018.07.114DOI Listing
November 2018
17 Reads

Chemosensitizing effect of honokiol in oral carcinoma stem cells via regulation of IL-6/Stat3 signaling.

Environ Toxicol 2018 Nov 4;33(11):1105-1112. Epub 2018 Aug 4.

School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.

Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide with poor prognosis. Numerous studies have attempted to explore alternative regimens aimed at reducing cancer stem cells (CSCs) without compromising the efficacy of conventional chemoradiotherapy. The present study sought to assess the effect of a natural compound honokiol on the reduction of elevated cancer stemness, metastatic capacity, and chemoresistance of oral carcinoma stem cells (OCSCs). Read More

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http://dx.doi.org/10.1002/tox.22587DOI Listing
November 2018
1 Read

Rare breast metastasis from adenoid cystic carcinoma of the submandibular gland.

BMJ Case Rep 2018 Aug 1;2018. Epub 2018 Aug 1.

Department of Surgery, Duke University Hospital, Durham, North Carolina, USA.

Adenoid cystic carcinomas (ACCs) are rare malignant neoplasms of exocrine glands, most commonly found in salivary glands. This report describes a 67-year-old woman with metastatic ACC to the breast, only the third reported case of its kind. The salivary gland ACC was first diagnosed 5 years prior. Read More

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http://dx.doi.org/10.1136/bcr-2017-223345DOI Listing
August 2018
4 Reads

Elective Neck Dissection for Management of Early- Stage Oral Tongue Cancer

Asian Pac J Cancer Prev 2018 Jul 27;19(7):1797-1803. Epub 2018 Jul 27.

Department of Surgical Oncology, National Cancer Institute, Cairo University, Egypt. Email:

Background: The occult neck metastasis rate is very high with tongue cancers. The aim of this study was to assess the current role of elective neck dissection (END) in management of early-stage oral tongue cancer with a focus on lymph node metastasis. In addition, effects of END on regional or systemic disease recurrence and survival were investigated. Read More

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http://dx.doi.org/10.22034/APJCP.2018.19.7.1797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165647PMC
July 2018
3 Reads

Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer.

Genome Med 2018 07 20;10(1):54. Epub 2018 Jul 20.

Department of Molecular and Cell Biology, Goldman School of Dental Medicine, Boston University School of Medicine, 72 East Concord Street, E4, Boston, MA, 02118, USA.

Background: Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy characterized by tumor heterogeneity, locoregional metastases, and resistance to existing treatments. Although a number of genomic and molecular alterations associated with HNSCC have been identified, they have had limited impact on the clinical management of this disease. To date, few targeted therapies are available for HNSCC, and only a small fraction of patients have benefited from these treatments. Read More

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http://dx.doi.org/10.1186/s13073-018-0569-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053793PMC
July 2018
37 Reads
4.942 Impact Factor

Functional considerations in oral cavity reconstruction.

Curr Opin Otolaryngol Head Neck Surg 2018 Oct;26(5):326-333

Massachusetts Eye and Ear Infirmary, Harvard School of Medicine, Boston, Massachusetts, USA.

Purpose Of Review: The treatment of oral cavity cancer may impair speech and swallowing function. Optimizing posttreatment function may lead to significant improvement of quality of life.

Recent Findings: Although oncologic control remains the main goal of treatment for oral cavity cancer, posttreatment function for surviving patients has over the last decades been recognized as an important secondary outcome. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000474DOI Listing
October 2018
19 Reads

Notch signalling induces epithelial‑mesenchymal transition to promote metastasis in oral squamous cell carcinoma.

Int J Mol Med 2018 Oct 12;42(4):2276-2284. Epub 2018 Jul 12.

School of Clinical Medicine, Hainan Medical University, Haikou, Hainan 571199, P.R. China.

The activation of Notch signalling induces epithelial‑mesenchymal transition (EMT), but this signalling pathway and its association with EMT in the context of cell motility in oral squamous cell carcinoma (OSCC) remains unclear. The present study aimed to investigate the role of the Notch signalling pathway and EMT in the metastatic potential of OSCC using 2 cell lines, Tca8113 and CAL27. The data demonstrated that zinc finger domain SNAI1 (Snail) knockdown by small interfering RNA decreased the expression of vimentin and increased the expression of epithelial cadherin (E‑cadherin). Read More

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http://dx.doi.org/10.3892/ijmm.2018.3769DOI Listing
October 2018

Metastasizing pleomorphic adenoma of parotid presenting as a huge renal mass.

Indian J Pathol Microbiol 2018 Jul-Sep;61(3):456-457

Department of Genitourinary Surgery, Government Medical College, Kottayam, Kerala, India.

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http://dx.doi.org/10.4103/IJPM.IJPM_111_17DOI Listing
January 2019
2 Reads

Metastatic squamous cell carcinoma in autotransplanted thyroid: A diagnostic dilemma.

Indian J Pathol Microbiol 2018 Jul-Sep;61(3):399-400

Department of Pathology, Maulana Azad Medical College, New Delhi, India.

Metastasis to the thyroid is uncommon. Mostly, they are tumors that originate in the lung or head or neck. Metastases from breast or kidney carcinomas and metastatic melanoma have also been reported. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_418_17DOI Listing
November 2018
12 Reads

Proteomic analysis of canine oral tumor tissues using MALDI-TOF mass spectrometry and in-gel digestion coupled with mass spectrometry (GeLC MS/MS) approaches.

PLoS One 2018 12;13(7):e0200619. Epub 2018 Jul 12.

Biochemistry Unit, Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.

Oral tumors, including highly invasive and metastatic oral melanoma (OM), non-tonsillar oral squamous cell carcinoma (OSCC) and benign tumors (BN), are common neoplasms in dogs. Although these tumors behave differently, limited data of their protein expression profiles have been exhibited, particularly at the proteome level. The present study aimed to i. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200619PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042759PMC
January 2019
14 Reads

Diagnostic accuracy of contrast-enhanced computed tomography for assessment of mandibular and medial retropharyngeal lymph node metastasis in dogs with oral and nasal cancer.

Vet Comp Oncol 2018 Dec 10;16(4):562-570. Epub 2018 Jul 10.

Department of Small Animal Clinical Sciences, University of Florida, Gainesville, Florida.

The diagnostic accuracy of contrast-enhanced CT for detection of cervical lymph node metastasis in dogs is unknown. The purpose of this retrospective, observational, diagnostic accuracy study was to assess the efficacy of CT for detection of mandibular and medial retropharyngeal lymph node metastasis in dogs. Histopathology of dogs with cancer of the head, CT and bilateral mandibular and medial retropharyngeal lymphadenectomy was reviewed. Read More

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http://dx.doi.org/10.1111/vco.12415DOI Listing
December 2018
1 Read

[Clinical application of folded free radial forearm flaps for reconstruction of full-tickness cheek defects after resection of buccal carcinoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(13):1002-1005

Department of Oral and Maxillofacial Surgery, the Affiliated Stomatology Hospital of Southwest Medical University, Luzhou, 646000, China.

To investigate the therapeutic effect of folded free radial forearm flaps (RFF) for reconstruction of full-tickness cheek defects after the resection of buccal carcinoma.Seventeen cases of buccal carcinoma received radical neck dissection with cheekectomy and mandibulectomy, and the folded RFF to reconstruct full-tickness cheek defects simultaneously. Preoperative Allen test, ultrasonic doppler blood flow meter examination or computed tomography angiography confirmed good vascular condition of the forearm. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.13.010DOI Listing
July 2018
8 Reads

3-O-Acetyloleanolic acid inhibits VEGF-A-induced lymphangiogenesis and lymph node metastasis in an oral cancer sentinel lymph node animal model.

BMC Cancer 2018 Jul 5;18(1):714. Epub 2018 Jul 5.

Department of Genetic Engineering and Graduate School of Biotechnology, Kyung Hee University, Yongin, 446-701, South Korea.

Background: Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O-acetyloleanolic acid (3AOA), a pentacyclic triterpenoid compound isolated from seeds of Vigna sinensis K., has been reported to have potent anti-angiogenesis and anti-tumor activities. Read More

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http://dx.doi.org/10.1186/s12885-018-4630-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034267PMC
July 2018
7 Reads

Oral Cancer Treatment: Still an Indication for Elective Neck Dissection?

ORL J Otorhinolaryngol Relat Spec 2018 4;80(2):96-102. Epub 2018 Jul 4.

University of São Paulo, São Paulo, Brazil.

Introduction: Oral squamous cell carcinoma has a high incidence and, although elective neck dissection is recommended, the removed nodes frequently present without metastasis. This surgical approach causes disabilities and increases possible surgical complications.

Objective: To evaluate the possibility of a watchful waiting approach in oral cancer. Read More

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https://www.karger.com/Article/FullText/490253
Publisher Site
http://dx.doi.org/10.1159/000490253DOI Listing
January 2019
6 Reads

Subcellular localization and expression of E-cadherin and SNAIL are relevant since early stages of oral carcinogenesis.

Pathol Res Pract 2018 Aug 20;214(8):1185-1191. Epub 2018 Jun 20.

Department of Biological Sciences, Bauru School of Dentistry - University of Sao Paulo, Alameda Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, SP, 17.012-901, Brazil. Electronic address:

The biological process of epithelial-to-mesenchymal transition (EMT) has been studied in oral squamous cell carcinoma (OSCC) metastasis, but it is rarely evaluated at several stages of oral carcinogenesis. This study aimed to analyze the presence of SNAIL and E-cadherin proteins, markers of EMT, in the development and progression of OSCC, evaluating excised specimens of potentially malignant lesions (oral leukoplakia with and without dysplasia-OL and OLD, respectively), tumor tissues (OSCC), metastatic lymph nodes (LN), and normal oral mucosa (NOM) by immunohistochemistry, considering subcellular localization. Additionally, SNAIL and E-cadherin transcripts were evaluated in vitro by qPCR, using SCC-9 cell line in comparison to human keratinocytes (HPEC). Read More

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http://dx.doi.org/10.1016/j.prp.2018.06.004DOI Listing
August 2018
6 Reads

A comprehensive genome-wide analysis of the long noncoding RNA expression profile in metastatic lymph nodes of oral mucosal melanoma.

Gene 2018 Oct 28;675:44-53. Epub 2018 Jun 28.

Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China. Electronic address:

Background & Aim: Oral mucosal melanoma (OMM) is a kind of malignancy with extremely rare morbidity. It exhibits a poorer biological behavior and clinical outcome compared with cutaneous melanoma. lncRNAs are endogenous cellular RNA transcripts with no protein-coding potential and are associated with oncogenesis through cis- or trans-acting mechanisms. Read More

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http://dx.doi.org/10.1016/j.gene.2018.06.064DOI Listing
October 2018
24 Reads

Healing of human critical-size alveolar bone defects secondary to cyst enucleation: a randomized pilot study with 12 months follow-up.

Minerva Stomatol 2018 Aug;67(4):148-155

Section of Dentistry, Department of Neurosciences, University of Padua, Padua, Italy.

Background: Alveolar bone cyst enucleation can give rise to critical-size defects whose healing may be incomplete due to the loss of periosteum or bone walls and there is a paucity of studies investigating the use of immediate bone grafts. The aim of this study was to compare spontaneous healing versus a deproteinized bovine bone graft.

Methods: In this prospective randomized clinical pilot study, twenty patients requiring the removal of a cyst ≥20 mm in maximum diameter were randomly assigned to one of two groups: deproteinized bovine bone grafting (test) or spontaneous healing (control). Read More

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http://dx.doi.org/10.23736/S0026-4970.18.04126-2DOI Listing
August 2018
1 Read

XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma.

Oncol Rep 2018 Aug 18;40(2):988-998. Epub 2018 Jun 18.

Key Lab for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, P.R. China.

X‑box‑binding protein 1 (XBP1) contributes to various types of cancer including breast, bladder cancer and esophageal squamous cell carcinoma. The aim of the study was to examine the metastatic role of XBP1 in oral squamous cell carcinoma (OSCC), and identify possible downstream molecules. Immunohistochemical staining was conducted on tissue microarrays comprising 96 OSCC cases to determine the expression level of XBP1 and analyze its association with metastasis, clinicopathological characteristics and survival prognosis. Read More

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http://dx.doi.org/10.3892/or.2018.6498DOI Listing
August 2018
6 Reads

Immune checkpoint-mediated myositis and myasthenia gravis: A case report and review of evaluation and management.

Am J Otolaryngol 2018 Sep - Oct;39(5):642-645. Epub 2018 Jun 5.

Case Western Reserve University School of Medicine, Cleveland, OH, USA; Department of Radiation Oncology, University Hospitals Seidman Cancer Center, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Background: We present a case of myositis and possible overlapping neuromuscular junction disorder following treatment with nivolumab for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC).

Methods: We report a 75-year-old man with recurrent stage IVA, T1N2cM0 oral cavity HNSCC treated with weight-dosed nivolumab who presented three weeks later with severe fatigue, generalized weakness, and bilateral ptosis. Evaluation demonstrated elevated creatine kinase and myopathic motor units on electromyography, supporting a diagnosis of an underlying muscle disease. Read More

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http://dx.doi.org/10.1016/j.amjoto.2018.06.003DOI Listing
January 2019
21 Reads

Overexpression of ADAM10 in oral squamous cell carcinoma with metastases.

Pol J Pathol 2018;69(1):67-72

ADAMs (a disintegrin and metalloproteinase) are important mediators of cell signalling events, which play a role in the pathogenesis and progression of cancers. Immunohistochemical method was used to examine the immunoexpression of ADAM10 and microvessel density in 80 cases of oral squamous cell carcinoma (OSCC): without metastases - OSCC M(-) (n = 38), and with metastases - OSCC M(+) (n = 42), in 24 cases of oral leukoplakia (OLK), (15 cases with low-grade dysplasia - OLK-LG, and 9 cases with high-grade dysplasia - OLK-HG), and 19 controls. The immunoexpression of ADAM10 and the mean number of vessels were significantly increased in both groups of OSCC in comparison to both groups of OLK and controls. Read More

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http://dx.doi.org/10.5114/pjp.2018.75339DOI Listing
July 2018
1 Read

Locoregional Control and Toxicity in Head and Neck Carcinoma Patients following Helical Tomotherapy-Delivered Intensity-Modulated Radiation Therapy Compared with 3D-CRT Data.

Oncology 2018 12;95(2):61-68. Epub 2018 Jun 12.

Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Objectives: To assess the feasibility and efficacy of intensity-modulated radiation implemented with helical tomotherapy image-guided with daily megavoltage computed tomography for head and neck cancer.

Methods: Between May 2010 and May 2013, 72 patients were treated with curative intent. The median age was 64 years, with 57% undergoing definitive and 43% postoperative radiotherapy. Read More

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http://dx.doi.org/10.1159/000489217DOI Listing
August 2018
5 Reads

A correlation of immunohistochemical expression of and in oral epithelial dysplasia and oral squamous cell carcinoma.

J Cancer Res Ther 2018 Apr-Jun;14(3):666-670

Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal University, Mangalore, Karnataka, India.

Purpose: Oral epithelial dysplasia (OED) occurs on exposure of epithelial cells to carcinogens and genetic alteration. Once the reversible cell damage is surpassed, cells either undergo apoptosis or transform into malignancy, chiefly oral squamous cell carcinoma (OSCC). Progressive accumulation of genetic errors (including mutations in TP53 and CDKN1A) is associated with the initiation and progression of potentially malignant oral lesions toward frank malignancy. Read More

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http://dx.doi.org/10.4103/0973-1482.180683DOI Listing
November 2018
2 Reads

Palatal schwannoma in a young female patient: report of a case and review of the literature.

Eur Arch Paediatr Dent 2018 Aug 7;19(4):279-285. Epub 2018 Jun 7.

Department of Oral Medicine and Pathology, School of Dentistry, National and Kapodistrian University of Athens, 2 Thivon Str, Goudi, 115 27, Athens, Greece.

Background: A few cases of oral schwannomas in paediatric patients have appeared in the literature so far; however, there are no studies focusing solely on paediatric oral schwannomas. The aim of this study is to report a case of palatal schwannoma in a young female patient and review the pertinent literature on oral schwannomas in paediatric patients.

Case Report: A 12-year-old girl presented with a growing swelling of 2 weeks duration on the hard palate. Read More

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http://dx.doi.org/10.1007/s40368-018-0349-5DOI Listing
August 2018
26 Reads

Metastasizing pleomorphic adenoma in the multiple organs: A case report on FDG-PET/CT imaging.

Medicine (Baltimore) 2018 Jun;97(23):e11077

Department of Pathology, The Cancer Institute Hospital of JFCR, Tokyo, Japan.

Rationale: Pleomorphic adenoma, the most common tumor of the salivary glands, is usually benign. It is well known, however, that pleomorphic adenomas occasionally undergo malignant transformation to carcinoma ex pleomorphic adenoma and can metastasize. More rarely pleomorphic adenomas can metastasize without histological malignant transformation. Read More

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http://dx.doi.org/10.1097/MD.0000000000011077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999481PMC
June 2018
5 Reads

Multidisciplinary Diagnostic and Surgical Management of Adenocarcinoma Gingival Metastases.

J Craniofac Surg 2018 Sep;29(6):e531-e534

Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania "Luigi Vanvitelli'.

Colon cancer is the third leading cause of cancer-related mortality worldwide and colon cancer metastases in rare sites, such as the oral cavity, lead to a worse prognosis. Oral metastasis is a rare clinical condition and it represents only the 1% among all oral cavity neoplasms. A multidisciplinary approach is recommended to carry out a correct diagnostic procedure that allows distinguishing between metastatic and primitive lesions of the oral cavity. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004632DOI Listing
September 2018
12 Reads

Atypical mandibular metastasis as the first presentation of a colorectal cancer.

BMJ Case Rep 2018 Jun 4;2018. Epub 2018 Jun 4.

Radiology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal.

We describe a case of a 70-year-old man presenting with a mandibular metastasis as the first sign of a mucinous adenocarcinoma of the rectum. After 6 months of a protracted toothache, the patient presented with a palpable mandibular mass and trismus, precluding adequate clinical evaluation. A CT scan was performed, and imaging findings suggested an aggressive primary jawbone tumour, most likely an osteosarcoma. Read More

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http://dx.doi.org/10.1136/bcr-2018-225094DOI Listing
June 2018
2 Reads

A Predictive Model to Determine the Pattern of Nodal Metastasis in Oral Squamous Cell Carcinoma.

Biomed Res Int 2018 13;2018:8925818. Epub 2018 May 13.

Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka.

Background: Developing histological prediction models that estimate the probability of developing metastatic deposit will help clinicians to identify individuals who need either radical or prophylactic neck dissection, which leads to better prognosis. Identification of accurate predictive models in oral cancer is important to overcome extensive prophylactic surgical management for neck nodes. Therefore, accurate prediction of metastasis in oral cancer would have an immediate clinical impact, especially to avoid unnecessary radical treatment of patients who are at a low risk of metastasis. Read More

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http://dx.doi.org/10.1155/2018/8925818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971289PMC
October 2018
1 Read

Pleomorphic adenoma of salivary glands: common and uncommon CT and MR imaging features.

Jpn J Radiol 2018 Aug 29;36(8):463-471. Epub 2018 May 29.

Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.

Pleomorphic adenoma (PA) is the most common salivary gland tumor and is characterized by cytomorphological and architectural diversity. On CT and MR images, PAs are shown as well-defined lesions occasionally accompanied by characteristic lobulated contours. On T2-weighted images, typical PAs show marked hyperintensity, which reflects the abundant myxochondroid stroma, with a hypointense rim indicating the fibrous capsule. Read More

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http://dx.doi.org/10.1007/s11604-018-0747-yDOI Listing
August 2018
17 Reads

Complications associated with surgical treatment of sleep-disordered breathing among hospitalized U.S. adults.

J Craniomaxillofac Surg 2018 Aug 24;46(8):1303-1312. Epub 2018 May 24.

Division of Epidemiology (DEPI), Office of Surveillance & Biometrics (OSB), Center for Devices and Radiological Health (CDRH), U.S. Food & Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA.

The purpose of this cross-sectional study is to examine the relationship between surgical treatments for sleep-disordered breathing (SDB) and composite measure of surgical complications in a nationally representative sample of hospital discharges among U.S. adults. Read More

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http://dx.doi.org/10.1016/j.jcms.2018.05.017DOI Listing
August 2018
3 Reads

Redefining Perineural Invasion: Integration of Biology With Clinical Outcome.

Neoplasia 2018 07 23;20(7):657-667. Epub 2018 May 23.

Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 N. University Ave, Ann Arbor, MI, USA;; Pathology, University of Michigan Medical School, 1500 E Medical Center Dr, Ann Arbor, MI, USA. Electronic address:

A diagnosis of perineural invasion (PNI), defined as cancer within or surrounding at least 33% of the nerve, leads to selection of aggressive treatment in squamous cell carcinoma (SCC). Recent mechanistic studies show that cancer and nerves interact prior to physical contact. The purpose of this study was to explore cancer-nerve interactions relative to clinical outcome. Read More

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http://dx.doi.org/10.1016/j.neo.2018.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030236PMC