5,296 results match your criteria Metastatic Neoplasms to the Oral Cavity


Duration of Cigarette Smoking Is a Stronger Risk Factor Than Number of Cigarettes Smoked per Day for Head and Neck Cancer, and Quitting Dramatically Lowers the Risk.

Authors:
Scott L Tomar

J Evid Based Dent Pract 2020 Mar 19;20(1):101419. Epub 2020 Feb 19.

Article Title And Bibliographic Information: Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: a bivariate spline model approach. Di Credico G, Edefonti V, Polesel J et al. Oral Oncol 2019;94:47-57. Read More

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http://dx.doi.org/10.1016/j.jebdp.2020.101419DOI Listing

Interdisciplinary rehabilitation of a primary intraosseous carcinoma including orthodontic archform management.

Quintessence Int 2020 ;51(6):464-472

Squamous cell carcinomas arising from keratocystic odontogentic tumors are a rare phenomenon in head and neck cancer, accounting for only 1.45% of oral squamous cell carcinomas, and are classified as primary intraosseous carninomas. This cancer is locally aggressive, has a high potential for recurrence, and requires radical resection and subsequent rehabilitation. Read More

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http://dx.doi.org/10.3290/j.qi.a44494DOI Listing

Mandibular Metastasis of a Recurrent Poorly Differentiated Urothelial Bladder Carcinoma.

J Clin Imaging Sci 2020 2;10:27. Epub 2020 May 2.

Department of Oral Medicine and Maxillofacial Radiology, Faculty of Dental Medicine, Lebanese University, Beirut, Lebanon.

Metastatic lesions to the oral cavity are uncommon; they represent between 1 and 3% of all malignant oral neoplasms. In this article, we report a rare case of metastatic urothelial bladder carcinoma in the mandible detected on oral radiographic images and confirmed with multiple imaging modalities. A 67-year-old woman presented to our clinic suffering from pain in the right side of the mandible with a mild swelling. Read More

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http://dx.doi.org/10.25259/JCIS_46_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193201PMC

[Correlation between high-risk TP53 mutation and extracapsular spread in oral squamous cell carcinoma].

Shanghai Kou Qiang Yi Xue 2019 Dec;28(6):644-647

Department of Oral and Maxillofacial Surgery, Gansu Provincial People's Hospital. Lanzhou 730000,Gansu Province,China.

Purpose: To investigate the correlation between high-risk tumor protein p53 (TP53) mutation and extracapsular spread(ECS) in oral squamous cell carcinoma (OSCC).

Methods: The data of 88 OSCC patients admitted to Gansu Provincial People's Hospital from January 2013 to January 2016 were retrospectively analyzed. The patients were divided into non-lymph node metastasis group (A1), lymph node metastasis without ECS group (A2), lymph node metastasis with ECS group(A3) according to the presence or absence of lymph node metastasis. Read More

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December 2019

Metastatic Tumors of the Oro-Facial Tissues: Clear Cell Renal Cell Carcinoma. A Clinico-Pathological and Immunohistochemical Study of Seven Cases.

J Clin Med 2020 Apr 17;9(4). Epub 2020 Apr 17.

Anatomic Pathology, Department of Emergency and Organ Transplantation, Università degli Studi di Bari Aldo Moro, 70100 Bari, Italy.

Metastases to orofacial tissues are infrequent, their incidence being 1-8% of malignant oral tumors, sometimes manifesting as the first clinical sign of an occult cancer. Renal cell carcinoma (RCC) is the second most common metastatic carcinoma to the oro-facial tissues, involving the jawbones, gingiva, oral mucosa, tongue or salivary glands. Also, RCC frequently displays a prominent clear cell component, which may predominate in the clear cell renal cell carcinoma subtype (CCRCC) and histologically mimic many other clear cell tumors, both benign and malignant, which can be epithelial (from keratinizing epithelia, cutaneous adnexa, salivary glands and odontogenic epithelium), melanocytic or mesenchymal in origin. Read More

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http://dx.doi.org/10.3390/jcm9041151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231269PMC

[Cervical lymph node metastasis in adenoid cystic carcinoma of the salivary glands: A clinicopathologic study].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):30-34

Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To investigate the incidence and clinicopathologic features of cervical lymph node metastasis in salivary gland adenoid cystic carcinoma (AdCC).

Methods: Retrospective analysis was made in 798 AdCC patients who underwent tumor resection during January, 2001 to January, 2019 in Peking University School and Hospital of Stomatology, especially the clincopathologic characteristics of 82 cases with lymph node metastasis.

Results: In the study, 82 of the 798 patients were identified with cervical lymph node metastasis, which was confirmed by histopathological examination. Read More

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February 2020

Phase II study of pembrolizumab and capecitabine for triple negative and hormone receptor-positive, HER2-negative endocrine-refractory metastatic breast cancer.

J Immunother Cancer 2020 Feb;8(1)

Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.

Background: Response rates to single agent immune checkpoint blockade in unselected pretreated HER2-negative metastatic breast cancer (MBC) are low. However, they may be augmented when combined with chemotherapy.

Methods: We conducted a single-arm, phase II study of patients with triple negative (TN) or hormone receptor-positive endocrine-refractory (HR+) MBC who were candidates for capecitabine. Read More

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http://dx.doi.org/10.1136/jitc-2019-000173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057426PMC
February 2020

Trends of mortality due to oral and oropharyngeal cancers in Uruguay from 1997 to 2014.

Med Oral Patol Oral Cir Bucal 2020 May 1;25(3):e403-e409. Epub 2020 May 1.

Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Odontologia, Rua Ramiro Barcelos, 2492, sala 503, CEP: 90035-003 Santana, Porto Alegre RS, Brazil

Background: To analyze the trends of oral and oropharyngeal cancer mortality in Uruguay between 1997 and 2014 according to sex and age groups and its possible association with sociodemographic factors.

Material And Methods: A time-series ecological study using secondary data was performed. The data about mortality due to oral and oropharyngeal cancers were obtained from the Statistics Vitals Department of the Public Health Ministry of Uruguay. Read More

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http://dx.doi.org/10.4317/medoral.23457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211375PMC

Differential expression of matrix metalloproteinases and miRNAs in the metastasis of oral squamous cell carcinoma.

BMC Oral Health 2020 01 29;20(1):24. Epub 2020 Jan 29.

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China.

Background: Our study aimed to reveal the regulatory mechanisms of miRNAs and matrix metalloproteinases (MMPs) in oral squamous cell carcinoma (OSCC).

Methods: The mRNA and miRNA expression profiles of six metastatic tumour samples, six nonmetastatic tumour samples, and six normal tissue samples were used for microarray analysis. Moreover, the important genes and miRNAs were validated by published profiles in Oncomine and by qRT-PCR. Read More

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http://dx.doi.org/10.1186/s12903-020-1013-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988311PMC
January 2020

Peripheral T cell lymphoma coexisting with Castleman's disease: A case report and literature review.

Medicine (Baltimore) 2020 Jan;99(2):e18650

Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of Traditional Chinese Medicine.

Rationale: Peripheral T cell lymphoma, coexisting with Castleman's disease (CD), is rarely seen in clinical practice and is not frequently reported in the literature.

Patient Concerns: A 68-year-old female was admitted to our hospital for the first time due to "multiple lumps in the neck that progressively enlarged over 7 months". 1. Read More

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http://dx.doi.org/10.1097/MD.0000000000018650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959880PMC
January 2020

IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice.

Int J Oral Sci 2020 01 2;12(1). Epub 2020 Jan 2.

Molecular Oncology Unit. Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.

Odontogenic tumours are a heterogeneous group of lesions that develop in the oral cavity region and are characterized by the formation of tumoural structures that differentiate as teeth. Due to the diversity of their histopathological characteristics and clinical behaviour, the classification of these tumours is still under debate. Alterations in morphogenesis pathways such as the Hedgehog, MAPK and WNT/β-catenin pathways are implicated in the formation of odontogenic lesions, but the molecular bases of many of these lesions are still unknown. Read More

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http://dx.doi.org/10.1038/s41368-019-0067-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946653PMC
January 2020

Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review.

Biomed Res Int 2019 22;2019:9869406. Epub 2019 Nov 22.

Department of Otorhinolaryngology-Head and Neck Surgery, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.

Myeloid sarcoma (MS) is a rarely encountered extramedullary localized tumor that is composed of immature myeloid cells. We reported an extremely rare case of MS with concurrent bone marrow (BM) involvement that invaded into a preexisting sebaceous lymphadenoma in the parotid gland and neck lymph nodes. Prompted by this case, we also present a literature review of MS invasion into salivary glands. Read More

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http://dx.doi.org/10.1155/2019/9869406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893249PMC

Clinical course and survival in patients with squamous cell carcinoma of the maxillary alveolus and hard palate: Results from a single-center prospective cohort.

J Craniomaxillofac Surg 2020 Jan 13;48(1):111-116. Epub 2019 Dec 13.

Department Oral and Maxillofacial Surgery, University Hospital of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.

Objectives: Operative management of squamous cell carcinoma of the maxillary alveolus and hard palate (MHSCC) is still a controversial issue, especially for cN0 cases. We report the survival outcomes in patients with MHSCC, including the rate of cervical occult metastasis for UICC stages I/II and survival after elective neck dissection (END).

Methods: 77 patients with primary MHSCC were followed-up from 2 months to 14. Read More

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http://dx.doi.org/10.1016/j.jcms.2019.12.008DOI Listing
January 2020

The preservation and application of the submandibular gland in oral squamous cell carcinoma (STROBE).

Medicine (Baltimore) 2019 Dec;98(52):e18520

Department of Head and Neck Surgrey.

This prospective study aimed to investigate metastases of oral squamous cell carcinoma (OSCC) to cervical lymph nodes and submandibular glands and to analyze the safety and feasibility of preserving and using submandibular glandular flaps to repair postoperative OSCC defects.Overall, 330 patients with OSCC who met the inclusion criteria were enrolled in the study from January 2014 to July 2018. OSCC metastasis to cervical lymph nodes and submandibular glands was investigated using intraoperative frozen section and postoperative pathological observation. Read More

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http://dx.doi.org/10.1097/MD.0000000000018520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946302PMC
December 2019

Introduction of a referral pathway guide for general dental practitioners in Cheshire & Merseyside: the effect on two-week suspected cancer referrals.

Br Dent J 2019 12;227(12):1058-1062

Evidence-Based Practice Research Centre (EPRC), Faculty of Health and Social Care, Edge Hill University, St Helens Road, Ormskirk, L39 4QP and Consultant Regional Maxillofacial Unit, University Hospital Aintree, Liverpool, L9 1AE, UK.

Introduction In 2017, Cheshire and Merseyside Local Dental Network introduced an Oral Cancer Care Guide for dental teams, emphasising the importance of early detection, appropriate referral, and effective patient communication. This study looks at the effect on two-week-wait (TWW) referrals to one unit, following the introduction of the guide and regional educational intervention.Methods Somerset Cancer Register, provided data from two three-month cohorts of TWW suspected head and neck cancer referrals, before and after introduction of the guide. Read More

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http://dx.doi.org/10.1038/s41415-019-1003-2DOI Listing
December 2019

Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma.

Asian Pac J Cancer Prev 2019 Dec 1;20(12):3635-3642. Epub 2019 Dec 1.

Division of Oral Pathology, Federal University of Ceará, Fortaleza, Ceará, Brazil.

Background: This estudie evaluated the immunostaining of cytokines in oral carcinoma, in tissue of margin of surgical resecate (MSR) and metastatic lymph nodes, as well as their role in patient prognosis.

Methods: A retrospective study was carried out in patients with oral squamous cell carcinomas, and sociodemographic and clinical-pathological data were evaluated. In addition, surgical site analysis of the patients was conducted by immunohistochemistry, using a tissue microarray for inflammatory (Tumor Necrosis Factor-alpha, Interleukin-1beta, Interleukin-6, interleukin-10), transcription NF-kappa B and CD68 markers. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.12.3635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173367PMC
December 2019

Prospective assessment of the clinical benefit of a tailored cancer gene set built on a next-generation sequencing platform in patients with recurrent or metastatic head and neck cancer.

Med Oncol 2019 Dec 21;37(2):12. Epub 2019 Dec 21.

Division of Medical Oncology, Washington University School of Medicine, 660 South Euclid, Campus Box 8056, St. Louis, MO, 63110, USA.

We performed a prospective trial to assess the clinical benefit of a tailored gene set built on a next-generation sequencing (NGS) platform in patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). Archived tumor tissue obtained from patients with recurrent or metastatic HNSCC was analyzed for variants by a tailored Comprehensive Cancer Gene set of 40 genes (CCG-40) performed on a NGS platform. These data were provided to clinicians to inform treatment decisions. Read More

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http://dx.doi.org/10.1007/s12032-019-1336-3DOI Listing
December 2019

Mortality due to oral and oropharyngeal cancer in Uruguay from 1997 to 2014.

J Appl Oral Sci 2020 28;28:e20190166. Epub 2019 Nov 28.

Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Odontologia, Porto Alegre, Rio Grande do Sul, Brasil.

Other: Oral and oropharyngeal cancer is considered a public health problem in several countries due to its high incidence and mortality rate.

Objective: This study aimed to analyze oral and oropharyngeal cancer mortality in Uruguay from 1997 to 2014 by age, sex and country region.

Methodology: A time series ecological study using secondary data was performed. Read More

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http://dx.doi.org/10.1590/1678-7757-2019-0166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886395PMC
December 2019

Oil Mouth Rinse Improves Chemotherapy-Induced Oral Mucositis in Patients with Acute Myeloid Leukemia.

Biomed Res Int 2019 30;2019:3619357. Epub 2019 Oct 30.

Department of Surgery, College of Medicine, University of Sulaimani, Kurdistan Region, Sulaimani, Iraq.

Objective: The present study aims at evaluating the beneficial effect of (NS) oil mouth rinse in the management of chemotherapy- (CT-) induced oral mucositis (OM) in patients with acute myeloid leukemia (AML).

Methods: Fifty-four AML patients were participated in this study and randomly allocated to either the test group or a control group. The patients of the test group received NS oil mouth rinse during 28-day CT, while the participants of the control group received a "magic mouthwash" formula. Read More

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http://dx.doi.org/10.1155/2019/3619357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875195PMC

Large volume haemorrhage following transoral robotic surgery (TORS) as a result of fibromuscular dysplasia: first reported case.

BMJ Case Rep 2019 Nov 24;12(11). Epub 2019 Nov 24.

Otolaryngology Head and Neck Surgery, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.

We present a case of a 61-year-old woman who suffered a haemorrhagic complication of an aneurysmal left lingual artery, secondary to fibromuscular dysplasia, following transoral robotic surgery (TORS). She was admitted through the emergency department 3 days after resection of a central base of tongue tumour. She suffered a massive haemorrhage requiring intensive care admission, blood transfusion, intubation, operative and endovascular intervention. Read More

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http://dx.doi.org/10.1136/bcr-2019-232022DOI Listing
November 2019

Metastasis of carcinoma of buccal mucosa to small intestine causing ileal perforation.

BMJ Case Rep 2019 Nov 19;12(11). Epub 2019 Nov 19.

General Surgery, BYL Nair Charitable Hospital, Mumbai, India

Oral cancers rarely metastasize to the small intestines. In a previously operated case of squamous cell carcinoma of buccal mucosa without any known preoperative distant metastases, we report a case of solitary ileal perforation 3 months after the surgery. The edge of the ileal perforation was positive for squamous cell carcinoma on histopathology. Read More

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http://dx.doi.org/10.1136/bcr-2019-231449DOI Listing
November 2019

Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy.

Cochrane Database Syst Rev 2019 11 20;2019(11). Epub 2019 Nov 20.

Faculty of Dentistry, University of Toronto, Toronto, Canada.

Background: Osteoradionecrosis (ORN) of the jaws is among the most serious oral complications of head and neck cancer radiotherapy, arising from radiation-induced fibro-atrophic tissue injury, manifested by necrosis of osseous tissues and failure to heal, often secondary to operative interventions in the oral cavity. It is associated with considerable morbidity and has important quality of life ramifications. Since ORN is very difficult to treat effectively, preventive measures to limit the onset of this disease are needed; however, the effects of various preventive interventions has not been adequately quantified. Read More

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http://dx.doi.org/10.1002/14651858.CD011559.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953365PMC
November 2019

Phase II study of everolimus and bevacizumab in recurrent ovarian, peritoneal, and fallopian tube cancer.

Gynecol Oncol 2020 01 15;156(1):32-37. Epub 2019 Nov 15.

University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Background: Recurrent ovarian, fallopian tube, and peritoneal cancers have limited potential for cure with traditional therapies. Preliminary results from a phase I study of everolimus and bevacizumab in advanced solid tumors showed it to be a promising combination. The primary objective of this study was to evaluate the 6-month progression-free survival for everolimus and bevacizumab in recurrent ovarian, peritoneal, and fallopian tube cancer. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.10.029DOI Listing
January 2020

Distant metastasis of follicular thyroid carcinoma to the mandible: a rare case report.

J Korean Assoc Oral Maxillofac Surg 2019 Oct 30;45(5):294-298. Epub 2019 Oct 30.

Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, Cheonan, Korea.

Treatment of metastatic carcinoma of the oral cavity can be a challenge due to its rarity. The current case report details metastatic carcinoma of the mandible originating from follicular thyroid carcinoma, which is the second most prevalent tumor of the thyroid. As the mandibular lesion developed, the primary thyroid lesion of thyroid. Read More

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http://dx.doi.org/10.5125/jkaoms.2019.45.5.294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838357PMC
October 2019

Mapping of sentinel lymph node drainage using SPECT/CT to tailor elective nodal irradiation in head and neck cancer patients (SUSPECT-2): a single-center prospective trial.

BMC Cancer 2019 Nov 14;19(1):1110. Epub 2019 Nov 14.

Department of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.

Background: The majority of patients with head and neck squamous cell carcinoma (HNSCC) receive bilateral elective nodal irradiation (ENI), in order to reduce the risk of regional failure. Bilateral ENI, as compared to unilateral ENI, is associated with higher incidence of acute and late radiation-induced toxicity with subsequent deterioration of quality of life. Increasing evidence that the incidence of contralateral regional failure (cRF) in lateralized HNSCC is very low (< 10%) suggests that it can be justified to treat selected patients unilaterally. Read More

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http://dx.doi.org/10.1186/s12885-019-6331-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857144PMC
November 2019

STAT1 inhibits T-cell exhaustion and myeloid derived suppressor cell accumulation to promote antitumor immune responses in head and neck squamous cell carcinoma.

Int J Cancer 2020 03 29;146(6):1717-1729. Epub 2019 Nov 29.

Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH.

Cancers of the oral cavity remain the sixth most diagnosed cancer worldwide, with high rates of recurrence and mortality. We determined the role of STAT1 during oral carcinogenesis using two orthotopic models in mice genetically deficient for Stat1. Metastatic (LY2) and nonmetastatic (B4B8) head and neck squamous cell carcinoma (HNSCC) cell lines were injected into the oral cavity of Stat1 deficient (Stat1 ) and Stat1 competent (Stat1 ) mice. Read More

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http://dx.doi.org/10.1002/ijc.32781DOI Listing

Is sequential free flap safe in oral cancer reconstruction in the same patient? An outcome and complication analysis.

Jpn J Clin Oncol 2020 Feb;50(2):152-158

Department of Biological Science and Technology, National Chiao-Tung University, Hsinchu City, Taiwan.

Background: Sequential free flap reconstruction in patient with head and neck cancer can provide reliable and effective wound coverage. Only a few studies have reported on the outcome and complications analysis but without consensus on the recipient vessels and flap chosen. Herein, we presented the outcome and analysed the risk factors for complications in sequential free flap reconstruction. Read More

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http://dx.doi.org/10.1093/jjco/hyz142DOI Listing
February 2020
1.747 Impact Factor

The Heterogenicity of Parotid Gland Squamous Cell Carcinoma: A Study of 49 Patients.

In Vivo 2019 Nov-Dec;33(6):2001-2006

Department of Radio-Oncology and Radiotherapy, Brandenburg Medical University-Theodor Fontane, Campus Ruppiner Kliniken, Neuruppin, Germany.

Background/aim: The aim of this study was to critically evaluate diagnostic workup, treatment and outcome of parotid gland squamous cell carcinoma (SCC).

Patients And Methods: We retrospectively examined 844 consecutive cases of parotid surgery in a German teaching hospital between 1975 and 2017.

Results: A total of 748 patients had parotid surgery. Read More

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http://dx.doi.org/10.21873/invivo.11696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899102PMC
March 2020
1 Read

Surgical management of the neck in patients with metastatic melanoma in parotid lymph nodes.

J Surg Oncol 2019 Dec 25;120(8):1462-1469. Epub 2019 Oct 25.

Department of Head and Neck Surgery, Chris O'Brien Lifehouse Cancer Centre, Sydney, Australia.

Background: The role and extent of neck dissection in patients with parotid metastatic cutaneous head and neck melanoma remain unclear. The aims of this study were to determine the incidence and patterns of cervical node involvement in patients with parotid metastatic melanoma, and to determine if a limited lymphadenectomy of the clinically negative neck is appropriate.

Methods: Patients who underwent parotidectomy and neck dissection for clinically apparent parotid metastatic melanoma, irrespective of neck status, were identified from two prospectively maintained databases. Read More

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http://dx.doi.org/10.1002/jso.25732DOI Listing
December 2019

Oral immune-related adverse events associated with PD-1 inhibitor therapy: A case series.

Oral Dis 2020 Mar 9;26(2):325-333. Epub 2020 Jan 9.

Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.

Objective: The aim of this study was to characterize clinical and histopathological features, and management outcomes of patients with oral immune-related adverse events (irAEs) secondary to programmed cell death-1 (PD-1) inhibitors.

Methods: This was a case series of cancer patients receiving PD-1 inhibitor therapy who were referred to oral medicine for the development of oral irAEs. Demographic, clinical, and histopathological data were collected from electronic medical records. Read More

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http://dx.doi.org/10.1111/odi.13218DOI Listing
March 2020
1 Read

Clinicopathologic analysis of verrucous hyperplasia, verrucous carcinoma and squamous cell carcinoma as part of the clinicopathologic spectrum of oral proliferative verrucous leukoplakia: A literature review and analysis.

Pathol Res Pract 2019 Dec 25;215(12):152670. Epub 2019 Sep 25.

Rambam medical center, Department of pathology, HaAliya HaShniya St 8, Haifa, 3109601, Haifa, Israel; Technion school of medicine, HaAliya HaShniya St 8, Haifa, 3109601, Haifa, Israel.

Objective: Proliferative verrucous leukoplakia is classified as a potentially malignant disorder because of its high rate of malignant transformation. PVL progresses in a series of clinical stages where the early stage represents multiple, multifocal leukoplakias with a high recurrence rate. The intermediate and late stages are clinically exophytic lesion, diagnosed microscopically as verrucous hyperplasia that often progresses into verrucous carcinoma and/or squamous cell carcinoma. Read More

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http://dx.doi.org/10.1016/j.prp.2019.152670DOI Listing
December 2019
1 Read

Metastatic hepatocellular carcinoma to the parotid gland: A diagnostic dilemma with review of the literature.

Indian J Pathol Microbiol 2019 Oct-Dec;62(4):582-585

Department of Oral and Maxillofacial Pathology, Dharamshila Narayana Hospital, New Delhi, India.

Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy and is a leading cause of cancer-related death worldwide. It has a very aggressive clinical course, with a mean survival rate of much less than a year if left untreated. Here, we present a case of a 68-year-old male with progressively enlarging painful right facial swelling, involving the ramus and condyle of mandible on contrast-enhanced computed tomography mimicking an osteosarcoma. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_272_19DOI Listing
February 2020
6 Reads

Case Report: Sarcoidosis mimicking head and neck cancer progression.

F1000Res 2019 25;8:215. Epub 2019 Feb 25.

Department of Medical Oncology, Instituto Português de Oncologia Francisco Gentil, Coimbra, Portugal.

Several case reports have been published describing the coexistence of sarcoidosis and cancer. In the literature, simultaneous occurrence of head and neck cancer and sarcoidosis is rarely reported. In this paper we present a case of a 42-year-old man with squamous cell carcinoma of the oral cavity, locally advanced, which after surgery and adjuvant radiotherapy developed local persistence and progression in the mediastinal lymph nodes. Read More

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http://dx.doi.org/10.12688/f1000research.17834.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777012PMC
June 2020
1 Read

[Lung adenocarcinoma with epidermal growth factor receptor mutation transferred to the oral cavity: a report of two cases].

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 10;54(10):691-693

Department of Pathology, The Fourth Hospital of Hebei Medical Universiry & The Tumor Hospital of Hebei Province, Shijiazhuang 050011, China.

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2019.10.008DOI Listing
October 2019

F-FDG PET/CT versus CT/MR imaging for detection of neck lymph node metastasis in palpably node-negative oral cavity cancer.

J Cancer Res Clin Oncol 2020 Jan 12;146(1):237-244. Epub 2019 Oct 12.

Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Purpose: Subclinical lymph node (LN) metastasis is associated with poor survival outcome in oral cavity squamous cell carcinoma (OCC), which alleges elective neck LN dissection. Preoperative detection of metastatic LNs may improve prognosis and proper management of OCC. We examined the clinical usefulness of fluorine 18-fluorodeoxyglucose (F-FDG) positron emission tomography (PET)/computed tomography (CT) for the detection of occult neck LN metastasis in OCC patients in comparison with conventional CT/magnetic resonance (MR) imaging. Read More

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http://dx.doi.org/10.1007/s00432-019-03054-3DOI Listing
January 2020
2 Reads

Metastatic breast cancer to bilateral mandibular ramus regions.

J Cancer Res Ther 2019 Jul-Sep;15(5):1177-1180

Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Necmettin Erbakan University, Konya, Turkey.

Metastatic carcinomas to the jaw bones are uncommon and comprise to about 1% of all malignant oral neoplasms. The purpose of this report is to present a rare case of metastatic breast carcinoma to bilateral mandibular ramus regions. The present case report is about a 40-year-old female patient with the complaints of a paresthesia in the right mandibular area of the last month duration. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_447_17DOI Listing
October 2019
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nab-Paclitaxel-based induction chemotherapy followed by cisplatin and radiation therapy for human papillomavirus-unrelated head and neck squamous-cell carcinoma.

Med Oncol 2019 Oct 8;36(11):93. Epub 2019 Oct 8.

Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

In patients with locally advanced human papillomavirus (HPV)-unrelated head and neck squamous-cell carcinoma (HNSCC), cisplatin and radiation therapy (CisRT) resulted in a local-regional recurrence (LRR) rate of 35%, progression-free survival (PFS) of 49%, and overall survival (OS) of 60%. We, and others, showed that nab-paclitaxel is an active agent in metastatic and locally advanced HNSCC. The aim of this report was to assess the efficacy of nab-paclitaxel-based induction chemotherapy and CisRT in HPV-unrelated HNSCC. Read More

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http://dx.doi.org/10.1007/s12032-019-1318-5DOI Listing
October 2019
2 Reads

Reminder of an important clinical lesson: breast cancer metastasis to the parotid gland.

BMJ Case Rep 2019 Oct 8;12(10). Epub 2019 Oct 8.

Pathology Department, Gloucestershire Royal Hospital, Gloucester, UK.

A 59-year-old woman presented to an otolaryngology clinic with an 8-week history of a painless lump over her left parotid gland. Her medical history included an invasive ductal carcinoma (33 mm) and a ductal carcinoma in situ (70 mm) of the right breast, for which she had a mastectomy and various adjuvant therapies. The primary tumour presented 8 years prior to the metachronous metastasis. Read More

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http://dx.doi.org/10.1136/bcr-2018-226494DOI Listing
October 2019
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Management of patients with hereditary angio-oedema in dental, oral, and maxillofacial surgery: a review.

Authors:
T Uzun

Br J Oral Maxillofac Surg 2019 12 4;57(10):992-997. Epub 2019 Oct 4.

Trabzon Oral and Dental Health Hospital, Department of Oral and Maxillofacial Surgery, DDS, Trabzon, Turkey. Electronic address:

Hereditary angio-oedema (HEA) is an autosomal dominant, life-threatening genetic disorder that is caused by insufficiency or dysfunction of the C1 esterase inhibitor that develops coincidentally with recurrent oedema in the skin, internal organs, and upper respiratory tract. Increased production of bradykinin secondary to increased plasma kallikrein activity is the primary cause of attacks. Dental procedures cause emotional stress and mechanical trauma and may also initiate attacks. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.09.008DOI Listing
December 2019
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Markers of the pre-metastatic niche "knock on the door" of metastasis-free cervical lymph nodes in patients with oral cancer.

Acta Histochem 2019 Nov 27;121(8):151447. Epub 2019 Sep 27.

Dept. Oral and Maxillofacial Surgery, The Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.

Aim: To assess expression of some markers of the pre-metastatic niche (PMN) in lymph nodes (LNs) of oral cancer patients.

Materials: LNs from metastatic-free neck dissections (LN0/N0, N = 43) and metastatic-free LNs in the vicinity of metastasis-containing LNs (LN0/N+, N = 30) were immuno-histochemically stained for lysyl oxidase (LOX), fibronectin (FN), vascular-endothelial growth factor receptor (VEGFR)-1 and matrix metalloproteinase (MMP)-9. Staining was assessed as 0 (no or weak staining), 1 (strong stain in 25% cells or extracellular area), 2 (same as 1 but in up to 50%) and 3 (same as 1 but in > than 50% of cells/area). Read More

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http://dx.doi.org/10.1016/j.acthis.2019.151447DOI Listing
November 2019
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Metastatic tumors in oral mucosa and jawbones: Unusual primary origins and unusual oral locations.

Acta Histochem 2019 Nov 27;121(8):151448. Epub 2019 Sep 27.

Department of Oral Pathology and Oral Medicine, Goldschleger School of Dental Medicine, Tel-Aviv University, Israel; Institute of Pathology, The Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.

Aim: To perform clinico-pathological characterization of a large series of oral metastases, collected from 3 main medical centers in Israel and compare findings to data on frequency of primary cancer types in the population.

Materials: Pathology archives were searched for cases of metastatic tumors to the oral soft tissues and jawbones, 1990 - 2016. Metastases to the skin of face or to major salivary glands have been excluded. Read More

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http://dx.doi.org/10.1016/j.acthis.2019.151448DOI Listing
November 2019
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Micro RNA Transcriptome Profile in Canine Oral Melanoma.

Int J Mol Sci 2019 Sep 28;20(19). Epub 2019 Sep 28.

Veterinary Teaching Hospital, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Kagoshima 890-0065, Japan.

MicroRNAs (miRNAs) dysregulation contribute the cancer pathogenesis. However, the miRNA profile of canine oral melanoma (COM), one of the frequent malignant melanoma in dogs is still unrevealed. The aim of this study is to reveal the miRNA profile in canine oral melanoma. Read More

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http://dx.doi.org/10.3390/ijms20194832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801976PMC
September 2019
2 Reads
2.862 Impact Factor

Utility of neck dissection for management of carcinoma of the parotid gland.

Br J Oral Maxillofac Surg 2019 12 26;57(10):1039-1043. Epub 2019 Sep 26.

Department of Otolaryngology, Head and Neck Surgery, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT.

To validate the use of neck dissection as part of the management of patients with parotid carcinomas, we retrospectively reviewed pathological and clinical data from the head and neck pathology archive at Guy's and St Thomas' Hospital on all patients who had primary parotid carcinomas resected between 1992 and 2014. The main outcome measure was the incidence of metastatic disease. A total of 54 of the 82 patients identified had neck dissections. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.09.002DOI Listing
December 2019
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Identification of inflammatory mediators associated with metastasis of oral squamous cell carcinoma in experimental and clinical studies: systematic review.

Clin Exp Metastasis 2019 12 26;36(6):481-492. Epub 2019 Sep 26.

College of Medicine and Dentistry, James Cook University, Cairns, QLD, 4878, Australia.

Metastasis, whether regional or distant, remains the main cause of morbidity and recurrence in oral cancer. The accumulating evidence suggests that inflammatory mediators are strong drivers for cancer progression and spread. However, the precise role of these inflammatory mediators in mediating specific metastatic stage is poorly understood due to lack of integration/validation of experimental research data and the clinical trials, i. Read More

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http://dx.doi.org/10.1007/s10585-019-09994-xDOI Listing
December 2019
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Rare brown tumour of the mandible secondary to tertiary hyperparathyroidism in a renal transplant recipient.

BMJ Case Rep 2019 Sep 24;12(9). Epub 2019 Sep 24.

Oral and Maxillofacial Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Brown tumours are rare osteolytic lesions that occur secondary to hyperparathyroidism (HPT). In 2% of all cases, the craniofacial bones are affected, most frequently the mandible. HPT is classified according to aetiology into three types, of which tertiary HPT is the rarest. Read More

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http://dx.doi.org/10.1136/bcr-2019-231231DOI Listing
September 2019
2 Reads

[Robotic-assisted supraomohyoid neck dissection via retroauricular hairline incision].

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Sep;54(9):628-631

Department of Oral and Maxillofacial Surgery, General Hospital of Chinese PLA, Beijing 100853, China.

To explore the feasibility of using da Vinci Surgical System to perform supraomohyoid neck dissection (SOND) to avoid visible scar and reduce trauma. Between September 2017 and December 2018, twenty patients (two females and 18 males, mean age, 54.8 years) with oral cancer treated in the Department of Stomatology, Hainan Hospital of General Hospital of Chinese PLA were enrolled in this study. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2019.09.009DOI Listing
September 2019
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A case of metastasis of small cell lung cancer to the parotid gland: a case report and literature review.

J Int Med Res 2019 Nov 23;47(11):5824-5830. Epub 2019 Sep 23.

Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin Province, China.

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http://dx.doi.org/10.1177/0300060519865645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862915PMC
November 2019
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A life-threatening drug-drug interaction between capecitabine and brivudine in a patient with metastatic breast cancer.

J Chemother 2019 Nov - Dec;31(7-8):424-427. Epub 2019 Sep 13.

First Department of Medicine, Laiko General Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.

In the current report we present the case of a patient experiencing a life-threatening drug-drug interaction involving the concurrent administration of capecitabine and brivudine. A 65- year-old female with metastatic breast cancer was commenced on brivudine for Herpes Zoster, while on capecitabine treatment, by a physician unfamiliar with the potential repercussions of this drug-drug interaction. As a result, she developed skin rash, severe oral mucositis, and severe and prolonged pancytopenia. Read More

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http://dx.doi.org/10.1080/1120009X.2019.1665875DOI Listing
April 2020
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Exosomes in head and neck cancer. Updating and revisiting.

J Enzyme Inhib Med Chem 2019 12;34(1):1641-1651

Oral Surgery and Implantology Unit, School of Medicine and Dentistry, Instituto de Investigación Sanitaria de Santiago (IDIS) , Santiago de Compostela , Spain.

Exosomes have gone from being considered simple containers of intracellular waste substances to be considered important carriers of cellular signals. Its broad capacity to promote tumour growth, both and metastatic, has greatly intensified scientific research on them. In the same way and depending on its content, its tumour suppressive properties have opened a window of light and hope in the fight against cancer. Read More

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http://dx.doi.org/10.1080/14756366.2019.1662000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746279PMC
December 2019
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A Correlative Study of N-Cadherin Expression with Different Grades of Oral Squamous Cell Carcinoma Projecting as a Marker of Epithelial to Mesenchymal Transition in Tumor Progression.

Asian Pac J Cancer Prev 2019 08 1;20(8):2327-2332. Epub 2019 Aug 1.

Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education(MAHE), Karnataka-576104, India.

Background: Epithelial cells typically express E-cadherin where as N-cadherin expressed by mesenchymal cells. The epithelial to mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell-cell adhesion, and gain migratory and invasive properties to become mesenchymal cells. EMT is typical for carcinoma cells during tumor progression and correlate with the local invasiveness and metastatic potential of the tumor. Read More

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http://journal.waocp.org/article_88681.html
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http://dx.doi.org/10.31557/APJCP.2019.20.8.2327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852818PMC
August 2019
1 Read