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    4752 results match your criteria Metastatic Neoplasms to the Oral Cavity

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    Comprehensive evaluation of clinical efficacy and safety of celecoxib combined with chemotherapy in management of gastric cancer.
    Medicine (Baltimore) 2017 Dec;96(51):e8857
    Department of Gastroenterology.
    Background: To evaluate the clinical efficacy and safety of celecoxib combined with chemotherapy in the treatment of gastric cancer.

    Methods: In total, 240 gastric cancer patients undergoing radical gastrectomy followed by adjuvant chemotherapy were randomly assigned into 2 groups. In the experimental group (n = 120), patients were administered with celecoxib-based chemotherapy, and chemotherapy alone was performed in the control group. Read More

    Low-grade myofibroblastic sarcoma of gastric cardia on 18F-FDG positron emission tomography/computed tomography: An extremely rare case report.
    Medicine (Baltimore) 2018 Jan;97(4):e9720
    Department of Nuclear Medicine.
    Rationale: Low-grade myofibroblastic sarcoma (LGMS) is a rare mesenchyme-derived tumor, which usually occurs in head, neck (especially tongue and mouth), and limbs. In this report, we described a case of gastric LGMS by F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT), which has not been reported previously.

    Patient Concerns: A 51-year-old female patient was admitted to our hospital with upper abdominal discomfort for 1 year and gradually increased eating difficulties over the last 3 months. Read More

    A case report of metastatic hepatocellular carcinoma in the mandible and coracoid process: A rare presentation.
    Medicine (Baltimore) 2018 Jan;97(4):e8884
    Department of Hepatology, Hospital Selayang, Batu Caves, Selangor, Malaysia.
    Rationale: We report a rare case of hepatocellular carcinoma (HCC) with metastases to the mandible and coracoid process of scapula without evidence of lung involvement.

    Patients Concerns: The patient was diagnosed with HCC, presented 5 months later with right lower tooth pain, swelling over the right mandible area and right shoulder pain.

    Diagnoses: Histopathological examination of mandible showed findings suggestive of metastatic HCC. Read More

    Head and Neck Cancer Tumor Seeding at the Percutaneous Endoscopic Gastrostomy Site.
    Nutr Clin Pract 2018 Feb 11;33(1):73-80. Epub 2018 Jan 11.
    Coram CVS Specialty Infusion Services, Denver, Colorado, USA.
    The National Institutes of Health National Cancer Institute estimates that over 13,000 new cases of head and neck cancer (HNC) will be diagnosed in 2017. Patients with HNC often require enteral nutrition (EN) via gastrostomy tube to provide nutrition support and hydration because of tumor obstruction of the oropharynx and/or cumulative effects of chemoradiation therapy. The percutaneous endoscopic gastrostomy (PEG) tube has become the preferred technique for EN access because placement is considered a minimally invasive procedure. Read More

    Metastatic retinoblastoma of the parotid and submandibular glands: a rare case report.
    BMC Ophthalmol 2017 Dec 2;17(1):229. Epub 2017 Dec 2.
    Department of Ophthalmology, Tangdu Hospital of Fourth Military Medical University, Xi'an, Shaanxi, China.
    Background: Retinoblastoma is the most common intraocular malignancy occurring in children. It can metastasize to the regional lymph nodes, central nervous system and distant organs usually the bones and bone marrow and very rarely to the soft tissue. Here, we report a case of unilateral retinoblastoma in a 4-year-old girl accompanied by a large metastasis of the parotid and submandibular glands that developed about 6 months previously and gradually increased in size 5 months after enucleation of the left eye. Read More

    Palonosetron Prevents Highly Emetogenic Chemotherapy-induced Nausea and Vomiting in Oral Cancer Patients.
    Anticancer Res 2017 12;37(12):6977-6981
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yamaguchi University, Yamaguchi, Japan.
    Background/aim: To evaluate the efficacy of palonosetron in preventing acute and delayed nausea and vomiting in patients receiving highly emetogenic chemotherapy (HEC) in oral cancer patients.

    Patients And Methods: Oral cancer patients receiving HEC were enrolled; among the 40 patients, 87 courses of chemotherapy were administered. On day 1, 0. Read More

    Case Report: Metastatic Infratemporal Soft Tissue Myeloma Presenting as a Numb Lower Lip.
    Dent Update 2017 Jan;44(1):53-4
    This is a case of a patient presenting to his general dental practitioner (GDP) with altered sensation in his lower lip with no obvious cause. Due to a prompt referral, the patient was investigated and diagnosed with an extramedullary presentation of multiple myeloma. A numb lip can present in general dental practice, although this is not common. Read More

    Roles of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinoma.
    PLoS One 2017 17;12(11):e0187092. Epub 2017 Nov 17.
    Department of Oral and Maxillofacial Pathobiology, School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
    Background: Vascular endothelial growth factor (VEGF) is a highly specific signaling protein for vascular endothelial cells that plays a critical role in tumor growth and invasion through angiogenesis, and may contribute to cell migration and activation of pre-osteoclasts, osteoclasts and some tumor cells.

    Objectives: We aimed to clarify the detailed roles of VEGF-Flt-1 signaling in bone invasion of oral squamous cell carcinoma (OSCC) cells.

    Results: Forty-two (42) of 54 cases with gingival SCC (77. Read More

    Oral primary care: an analysis of its impact on the incidence and mortality rates of oral cancer.
    BMC Cancer 2017 Oct 30;17(1):706. Epub 2017 Oct 30.
    Faculty of Medicine, Department of Social Medicine, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
    Background: Oral cancer is a potentially fatal disease, especially when diagnosed in advanced stages. In Brazil, the primary health care (PHC) system is responsible for promoting oral health in order to prevent oral diseases. However, there is insufficient evidence to assess whether actions of the PHC system have some effect on the morbidity and mortality from oral cancer. Read More

    Limited evidence for interventions to treat oral leukoplakia.
    Evid Based Dent 2017 10;18(3):92-93
    New York University College of Dentistry, New York, USA.
    Data sourcesCochrane Oral Health's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline Ovid, Embase, Ovid, CancerLit via PubMed. MetaRegister of Controlled Trials, ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform were searched for ongoing trials. Read More

    Exercise therapy for trismus secondary to head and neck cancer: A systematic review.
    Head Neck 2017 Nov 14;39(11):2352-2362. Epub 2017 Jul 14.
    Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, The Netherlands.
    Background: Effects of exercise therapy for trismus secondary to head and neck cancer have not been reviewed systematically since 2004.

    Methods: Four databases were searched. The quality of observational studies and randomized controlled trials was assessed. Read More

    Anterograde injection of low-dose urokinase salvages free anterolateral thigh flap: A case report of safe and effective treatment.
    Medicine (Baltimore) 2017 Oct;96(41):e7932
    Department of Plastic Surgery, China Medical University Hospital, Taichung, Taiwan.
    Rationale: A 54-year-old Taiwanese male came to our hospital presented with right retromolar mucoepidermoid carcinoma. Composite resection and right modified radical neck dissection were performed. We then use free anteral lateral thigh flap to reconstruct the defect. Read More

    "Atypical" salivary gland fine needle aspiration: Risk of malignancy and interinstitutional variability.
    Diagn Cytopathol 2017 Dec 29;45(12):1088-1094. Epub 2017 Sep 29.
    Department of Laboratory Medicine and Pathology, Temple University Hospital, Pennsylvania.
    Background: Fine needle aspiration (FNA) is widely used in the diagnosis of salivary gland lesions. Salivary gland FNAs are often difficult to diagnose because of morphologic heterogeneity, a small but significant number of the FNAs yield "atypical" diagnosis. However, systematic evaluation of the risk of malignancy (ROM) of the atypical diagnoses across institutions and the variability of ROM among institutions are still lacking. Read More

    Metastatic Lymph Node Burden and Survival in Oral Cavity Cancer.
    J Clin Oncol 2017 Nov 7;35(31):3601-3609. Epub 2017 Sep 7.
    All authors: Cedars-Sinai Medical Center, Los Angeles, CA.
    Purpose Current staging systems for oral cavity cancers incorporate lymph node (LN) size and laterality, but place less weight on the total number of positive metastatic nodes. We investigated the independent impact of numerical metastatic LN burden on survival. Methods Adult patients with oral cavity squamous cell carcinoma undergoing upfront surgical resection for curative intent were identified in the National Cancer Data Base between 2004 and 2013. Read More

    Solitary Fibrous Tumors of the Head and Neck: A Multi-Institutional Clinicopathologic Study.
    Am J Surg Pathol 2017 Dec;41(12):1642-1656
    *Departments of Pathology and Surgery, VCU School of Medicine, Richmond, VA †Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA §Biostatistics Facility, University of Pittsburgh Cancer Institute **Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA ∥Department of Pathology, SUNY Upstate Medical University, Syracuse, NY Departments of ‡Pathology ¶Dermatology ††Oral and Maxillofacial Surgery, University of Michigan Health System, Ann Arbor #Department of Urology, Henry Ford Health System, Detroit, MI.
    Solitary fibrous tumors (SFTs) of the head and neck are uncommon. Lesions previously diagnosed in the head and neck as hemangiopericytomas (HPCs), giant cell angiofibromas (GCAs), and orbital fibrous histiocytomas (OFHs) are now recognized as within the expanded spectrum of SFTs. To better understand the clinicopathologic profile of head and neck SFTs, we performed a multi-institutional study of 88 examples. Read More

    [Description of the GORTEC 2017-03 study: Postoperative stereotactic radiotherapy for early stage oropharyngeal and oral cavity cancer with high risk margin (PHRC-K-16-164)].
    Cancer Radiother 2017 Oct 31;21(6-7):527-532. Epub 2017 Aug 31.
    Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, 63011 Clermont-Ferrand, France.
    The GORTEC 2017-03-Stereo-postop study is a phase 2, multicentric, nationwide study, funded by the hospital clinical research program (PHRC). The sponsor is Centre Jean-Perrin in Clermont-Ferrand, in partnership with the GORTEC. The principal investigators are Dr J Biau and Dr M Lapeyre. Read More

    Metastatic Basal Cell Adenocarcinoma of Submandibular Gland to the Spine: An Extremely Rare Condition.
    World Neurosurg 2017 Dec 24;108:989.e9-989.e14. Epub 2017 Aug 24.
    Spine Unit, Institute of Orthopaedics, Lerdsin Hospital, Bangkok, Thailand.
    Background: Basal cell adenocarcinomas are rare malignant neoplasms of salivary glands, accounting for <1% of salivary gland tumors. Few cases of distant metastases have been reported.

    Case Description: A 50-year-old Thai man was diagnosed with basal cell adenocarcinoma of the submandibular gland with pulmonary and cervical spine metastases with progressive myelopathy. Read More

    LncRNAAC132217.4, a KLF8-regulated long non-coding RNA, facilitates oral squamous cell carcinoma metastasis by upregulating IGF2 expression.
    Cancer Lett 2017 Oct 18;407:45-56. Epub 2017 Aug 18.
    Institute of Cancer Stem Cell & College of Stomatology, Dalian Medical University, Dalian 116044, China. Electronic address:
    Increasing evidence has revealed the aberrant expression of long non-coding RNAs (lncRNAs) in many cancer types, including oral squamous cell carcinoma (OSCC). However, limited investigations report metastasis-related lncRNAs in OSCC. Herein, we report the identification of dysregulated intergenic lncRNAs in the highly metastatic OSCC cell line, UM-SCC6H. Read More

    [Parotid metastasis from carcinoma of the breast: report of a case and review of the literature].
    Pan Afr Med J 2017 2;27:79. Epub 2017 Jun 2.
    Service d'Oncologie Médicale, CHU Hassan II Fès, Maroc.
    Parotid metastasis from carcinoma of the breast is very rare, only a few cases have been reported in the literature. We here report the case of a 43-year old patient treated for right breast cancer in whom left parotid metastasis (confirmed histologically) occurred two years after the end of the treatment. Read More

    Paraneoplastic mucous membrane pemphigoid with ocular and laryngeal involvement.
    BMJ Case Rep 2017 Aug 11;2017. Epub 2017 Aug 11.
    Département des Neurosciences Cliniques, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
    A 73-year-old woman was treated 8 years previously for synchronous breast and uterine neoplasms. She presented with a severe sore throat, odynophagia, dysphonia, dyspnoea, ocular irritation and weight loss over the last 3 months. Physical examination revealed ulcerations in the oral cavity, posterior pharyngeal wall and supraglottic larynx, nasal crusting, bilateral conjunctivitis and three cutaneous blisters. Read More

    EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis.
    Oncogene 2017 Nov 31;36(47):6542-6554. Epub 2017 Jul 31.
    Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan, ROC.
    Current anti-epidermal growth factor receptor (EGFR) therapy for oral cancer does not provide satisfactory efficacy due to drug resistance or reduced EGFR level. As an alternative candidate target for therapy, here we identified an oncogene, ROS1, as an important driver for oral squamous cell carcinoma (OSCC) metastasis. Among tumors from 188 oral cancer patients, upregulated ROS1 expression strongly correlated with metastasis to lung and lymph nodes. Read More

    Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis.
    Lancet Oncol 2017 Sep 27;18(9):1221-1237. Epub 2017 Jul 27.
    Department of Radiation Therapy, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.
    Background: The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of altered fractionation within the context of concomitant chemotherapy with the inclusion of new trials.

    Methods: For this updated meta-analysis, we searched bibliography databases, trials registries, and meeting proceedings for published or unpublished randomised trials done between Jan 1, 2009, and July 15, 2015, comparing primary or postoperative conventional fractionation radiotherapy versus altered fractionation radiotherapy (comparison 1) or conventional fractionation radiotherapy plus concomitant chemotherapy versus altered fractionation radiotherapy alone (comparison 2). Read More

    Highly Eribulin-resistant KBV20C Oral Cancer Cells Can Be Sensitized by Co-treatment with the Third-generation P-Glycoprotein Inhibitor, Elacridar, at a Low Dose.
    Anticancer Res 2017 08;37(8):4139-4146
    School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea
    Background/aim: Eribulin mesylate, also called Halaven® (HAL), was recently developed as a microtubule-targeting drug and is used in the clinic for resistant or metastatic cancer. Previously, we showed that P-glycoprotein (P-gp)-overexpressing KBV20C oral cancer cells are highly resistant to HAL compared to sensitive KB cells. This qualitative study was designed to identify specific P-gp inhibitors that increase the sensitivity of highly resistant cancer cells to HAL. Read More

    [Application of muscle pedicled platysma myocutaneous flap in the reconstruction of buccal mucosa defects].
    Hua Xi Kou Qiang Yi Xue Za Zhi 2017 Apr;35(2):162-166
    Centre of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China.
    Objective: This study aimed to explore the main features and advantages of the muscle pedicled platysma myocutaneous flap (PMF), the degree of improvement of flap harvest. To evaluate the application value of the flap in the reconstruction of buccal mucosa carcinoma defects.

    Methods: Twenty-three patients received PMF with MacFee incision to reconstruct buccal mucosa defects that were caused by the resection of precancer lesions and benign and malignant tumors from August 2012 to April 2015. Read More

    Overexpression of glutathione peroxidase 1 predicts poor prognosis in oral squamous cell carcinoma.
    J Cancer Res Clin Oncol 2017 Nov 26;143(11):2257-2265. Epub 2017 Jun 26.
    Department of Otolaryngology, Asan Medical Centre, University of Ulsan College of Medicine, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
    Purpose: Intracellular antioxidant enzymes are commonly upregulated in various cancer types and are associated with treatment outcomes. Because the relationship has rarely been examined in oral squamous cell carcinoma (OSCC), we aimed to evaluate the association between the levels of glutathione peroxidase (GPX)1, GPX4, and thioredoxin reductase (TrxR)1 expression and prognosis in patients with OSCC who underwent curative surgical resection.

    Methods: This study included 233 patients who underwent curative surgery for previously untreated OSCC between 2000 and 2012. Read More

    Oral squamous cell carcinoma patients can be differentiated from healthy individuals with label-free serum proteomics.
    Br J Cancer 2017 Jul 20;117(3):376-384. Epub 2017 Jun 20.
    Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki 00290, Finland.
    Background: No blood biomarkers to detect early oral cavity squamous cell carcinoma (OSCC) without clinical signs exist - diagnosis is solely based on histology of a visible tumour. Most OSCC patients are diagnosed at advanced stage, which leads to significant morbidity and poor survival. Our aim was to find the serum screening or detection biomarkers in OSCC. Read More

    Bifunctional Enzyme JMJD6 Contributes to Multiple Disease Pathogenesis: New Twist on the Old Story.
    Biomolecules 2017 Jun 1;7(2). Epub 2017 Jun 1.
    Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, 4101 Woolworth Avenue, Omaha, NE 68105, USA.
    Jumonji domain-containing protein 6 (JMJD6) is a non-heme Fe(II) 2-oxoglutarate (2OG)-dependent oxygenase with arginine demethylase and lysyl hydroxylase activities. Its initial discovery as a dispensable phosphatidylserine receptor (PSR) in the cell membrane of macrophages for phagocytosis was squashed by newer studies which revealed its nuclear localization and bifunctional enzymatic activity. Though its interaction with several nuclear and cytoplasmic target proteins has been demonstrated, the exact mechanisms and clinical significance of these various biologic interplays are not yet well established. Read More

    NUT carcinoma presenting in the palate - a case report.
    APMIS 2017 Oct 25;125(10):933-936. Epub 2017 May 25.
    Department of Oral & Maxillofacial Surgery, Rigshospitalet, Copenhagen, Denmark.
    NUT carcinomas (NC) are rare and aggressive tumours characterized by chromosomal rearrangements of the gene encoding for nuclear protein of the testis (NUT) located on chromosome 15q14. This article presents a case of a 60-year-old woman diagnosed with NC presenting as a fast growing primary tumour in the right palate. Further evaluation revealed a tumour mass in the lungs and widespread metastases. Read More

    Patterns of Treatment Failure and Postrecurrence Outcomes Among Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma After Chemoradiotherapy Using Modern Radiation Techniques.
    JAMA Oncol 2017 Nov;3(11):1487-1494
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
    Importance: Even though 15% to 50% of patients with head and neck squamous cell carcinoma (HNSCC) experience recurrence, relatively little is known regarding patterns of treatment failure and postrecurrence outcomes after chemoradiotherapy using modern radiation techniques (intensity-modulated radiotherapy [IMRT]). Recurrence patterns are significantly affected by variations in the quality of radiotherapy, which may confound findings from multicenter trials.

    Objective: To assess patterns of treatment failure and postrecurrence outcomes for patients with HNSCC treated with contemporary radiotherapy techniques. Read More

    Clinical and prognostic significance of HIF-1α overexpression in oral squamous cell carcinoma: a meta-analysis.
    World J Surg Oncol 2017 May 18;15(1):104. Epub 2017 May 18.
    Department of Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, Jinan, Shandong, 250012, China.
    Background: Recent studies have indicated an association between hypoxia inducible factor-1 alpha (HIF-1α) expression and poor prognosis in patients with oral squamous cell carcinoma (OSCC); however, definitive evidence of this association is yet to be obtained. We performed a meta-analysis to evaluate the association of HIF-1α expression with clinicopathological characteristics and overall survival (OS) of patients with OSCC.

    Methods: A literature search for relevant studies published in English language as of February 05, 2016, was performed on PubMed, Web of Science, and EMBASE databases. Read More

    Mouth examination performance by children's parents and by adolescents in Fanconi anemia.
    Pediatr Blood Cancer 2017 Nov 13;64(11). Epub 2017 May 13.
    Department of Stomatology, Post Graduate Program in Dentistry, Federal University of Paraná School of Dentistry, Curitiba, Paraná, Brazil.
    Background: Fanconi anemia (FA) is a rare genetic syndrome characterized by increased risk of developing malignant neoplasms, particularly oral squamous cell carcinoma. This study aims to ascertain the extent to which adolescents and guardians/parents of children with FA are aware of their oral cancer risks and assess their ability to perform mouth examination (ME).

    Procedure: A cross-sectional study was conducted among patients with FA (between 6 and 16 years) and their parents. Read More

    The cost of major head and neck cancer surgery.
    N Z Med J 2017 May 12;130(1455):111-119. Epub 2017 May 12.
    Wellington Regional Plastic, Maxillofacial and Burns Unit, Hutt Hospital; and Gillies McIndoe Research Institute, Wellington.
    Aim: This study quantified the cost of major head and neck cancer (HNC) surgery.

    Methods: Consecutive patients undergoing major HNC surgery between July 2007 and June 2012 were identified from our head and neck database. Patient demographics, tumour type, site, stage and types of resection and reconstruction, length of stay and surgical complications occurring within six months of initial surgery were retrospectively analysed. Read More

    Analysis of risk factors for oral cavity and oropharynx cancer in the authors' own material.
    Otolaryngol Pol 2017 Apr;71(2):23-28
    Klinika Otolaryngologii i Onkologii Laryngologicznej II Katedry Otolaryngologii UM w Łodzi Kierownik: prof. dr hab. med. J. Olszewski.
    Introduction: The aim of the study was to analyse the risk factors for oral cavity and oropharynx cancer in peopled examined under the Head and Neck Cancer Awareness Week in 2016, Lodz.

    Material And Methods: In Lodz, 21st September 2016, under the Head and Neck Cancer Awareness Week, 106 people, including 67 women aged 29-77 and 39 men aged 23-84, underwent preventive examinations in the hospital department. Prior to the laryngological examination, the patients were asked to answer questions that referred to their education, medical case history, symptoms, smoking habits with the number of cigarettes per day, alcohol intake, the number of lifetime sexual partners, oral sex engagement, incidents of head and neck cancer in the family history. Read More

    Surgical Treatment for Pulmonary Metastasis of Head and Neck Cancer: Study of 58 Cases.
    Ann Thorac Cardiovasc Surg 2017 Aug 9;23(4):169-174. Epub 2017 May 9.
    Division of Thoracic Surgery, Saitama Cancer Center, Kitaadachi-gun, Saitama, Japan.
    Purpose: Although the number of surgeries performed for pulmonary metastasis of head and neck cancer has been increasing, there have been few reports of the surgical effectiveness. We collected the data of surgeries performed in our facility in order to discuss the surgical performance and indication.

    Methods: We retrospectively examined the prognosis and predictors for 58 patients with pulmonary metastasis of head and neck cancer who underwent a surgery in our facility during the 15-year period, from January 2000 to December 2015. Read More

    Coexpression of growth differentiation factor 11 and reactive oxygen species in metastatic oral cancer and its role in inducing the epithelial to mesenchymal transition.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jun 20;123(6):697-706. Epub 2017 Mar 20.
    Department of Oral and Maxillofacial Surgery, College of Stomatology, Guangxi Medical University, Nanning, Guangxi, China. Electronic address:
    Objectives: The aim of this study was to investigate growth differentiation factor 11 (GDF11) and reactive oxygen species (ROS) expression in metastatic oral cancer and explored their roles in inducing epithelial to mesenchymal transition (EMT).

    Study Design: The expression of GDF11, ROS, and EMT-related markers was evaluated in primary tumor tissues from patients with oral squamous cell carcinoma (OSCC). SCC-9 cells, a human tongue carcinoma cell line, were treated with recombinant GDF11. Read More

    In vitro and in vivo anticancer activity of posterior salivary gland toxin from the cuttlefish Sepia pharaonis, Ehrenberg (1831).
    Chem Biol Interact 2017 Jun 4;272:10-20. Epub 2017 May 4.
    Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, 603 103, Tamil Nadu, India. Electronic address:
    Posterior salivary gland (PSG) toxins are high molecular weight toxins secreted by cephalopods and gastropods which possess immense potentials in biomedical applications. In the present study, the biomedical potentials of the PSG toxin from the cuttlefish, S. pharaonis was determined in vitro and in vivo. Read More

    Beyond Positive Margins and Extracapsular Extension: Evaluating the Utilization and Clinical Impact of Postoperative Chemoradiotherapy in Resected Locally Advanced Head and Neck Cancer.
    J Clin Oncol 2017 May 13;35(14):1550-1560. Epub 2017 Feb 13.
    Daniel M. Trifiletti and Paul Read, University of Virginia, Charlottesville, VA; Andrew Smith, Nandita Mitra, Surbhi Grover, John N. Lukens, Roger B. Cohen, Alexander Lin, and Samuel Swisher-McClure, University of Pennsylvania, Philadelphia, PA; and William M. Mendenhall, University of Florida, Gainesville, FL.
    Purpose To examine recent utilization and survival outcomes associated with use of adjuvant chemoradiotherapy (CRT) for patients with resected locally advanced head and neck cancer (LAHNC) with negative surgical margins (SM negative) and no extracapsular extension (ECE). Materials and Methods We conducted a retrospective observational cohort study using the National Cancer Database evaluating patients diagnosed in 2004 to 2012 with AJCC stage III to IVB squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx treated with definitive surgery and adjuvant radiotherapy (RT) or CRT. We identified a subset of patients with SM negative and no ECE (n = 10,870). Read More

    Histological Assessment of the Carotid Sheath in Patients With Oral Squamous Cell Carcinoma.
    J Oral Maxillofac Surg 2017 Nov 4;75(11):2465-2476. Epub 2017 Apr 4.
    Associate Professor, Department of Oral Pathology and Microbiology, SDM College of Dental Sciences and Hospital, Sattur, Dharwad, Karnataka, India.
    Purpose: During surgical management of the neck using various types of neck dissection, the carotid sheath is removed, in particular, the part adjacent to the jugular lymph node chain, with the intention of preventing recurrence from the lymphatics present within it. The role of the carotid sheath as a potential origin for nodal recurrence has not been proved thus far. Working in a tissue plane between the carotid sheath and the neurovascular structures of the neck can lead to a greater chance of damage to these structures. Read More

    IQGAP1 is an oncogenic target in canine melanoma.
    PLoS One 2017 26;12(4):e0176370. Epub 2017 Apr 26.
    Program in Epithelial Biology, Stanford University, Stanford, California, United States of America.
    Canine oral mucosal melanoma is an aggressive malignant neoplasm and is characterized by local infiltration and a high metastatic potential. The disease progression is similar to that of human oral melanomas. Whereas human cutaneous melanoma is primarily driven by activating mutations in Braf (60%) or Nras (20%), human mucosal melanoma harbors these mutations much less frequently. Read More

    Inhibition of αvβ3 integrin induces loss of cell directionality of oral squamous carcinoma cells (OSCC).
    PLoS One 2017 24;12(4):e0176226. Epub 2017 Apr 24.
    Department of Morphological Sciences, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, Porto Alegre, RS, Brazil, CEP.
    The connective tissue formed by extracellular matrix (ECM) rich in fibronectin and collagen consists a barrier that cancer cells have to overpass to reach blood vessels and then a metastatic site. Cell adhesion to fibronectin is mediated by αvβ3 and α5β1 integrins through an RGD motif present in this ECM protein, thus making these receptors key targets for cell migration studies. Here we investigated the effect of an RGD disintegrin, DisBa-01, on the migration of human fibroblasts (BJ) and oral squamous cancer cells (OSCC, SCC25) on a fibronectin-rich environment. Read More

    Congenital amelanotic melanoma in a crossbred heifer calf.
    J Vet Diagn Invest 2017 Jul 19;29(4):544-547. Epub 2017 Apr 19.
    Departments of Veterinary Clinical Sciences (Winslow, Gilliam), Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK.
    A large, pedunculated cutaneous mass protruding from the left flank fold and an enlarged left prefemoral lymph node were found on examination of a 3-d-old crossbred Aberdeen Angus heifer. The calf was asymptomatic aside from peripheral lymphadenopathy, and the mass, along with the left prefemoral lymph node, was surgically excised. Histologic examination of the mass and the lymph node revealed a homogeneous population of neoplastic cells that stained positively with immunohistochemical stains S100 and melan A, supporting a diagnosis of congenital amelanotic melanoma with nodal metastasis. Read More

    One-Stage Supramaximal Full-Thickness Wedge Resection of Vascular Lip Anomalies.
    J Oral Maxillofac Surg 2017 Nov 22;75(11):2449-2455. Epub 2017 Mar 22.
    Staff, Vascular Birthmark Institute of New York, Department of Otolaryngology, Lenox Hill and Manhattan Eye, Ear, and Throat Hospitals, New York, NY; Assistant Clinical Professor, Department of Ophthalmology, Harvard Medical School, Boston, MA. Electronic address:
    Purpose: Vascular lip anomalies include infantile hemangiomas, venous malformations, and arteriovenous malformations. Surgical management can be complicated by alterations in horizontal length, vertical height, and lip thickness from the underlying pathology. Additional reconstructive challenges include preservation of oral continence, vermillion definition, and the sublabial sulcus. Read More

    Multiple clear-cell sarcomas of small intestine with parotid gland metastasis: A case report.
    World J Gastroenterol 2017 Mar;23(12):2258-2265
    Hao Su, Peng Wang, Lei Shi, Hai-Tao Zhou, Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
    Clear-cell sarcoma is a rare, malignant soft tissue tumor that displays melanocytic differentiation with a distinct molecular profile. It is rarely localized in the gastrointestinal tract. Herein we reported a case of multiple synchronous clear-cell sarcomas of the gastrointestinal tract with parotid gland metastasis. Read More

    Oral and Cutaneous Lymphomas other than Mycosis Fungoides and Sézary Syndrome in a Mexican Cohort: Recategorization and Evaluation of International Geographical Disparities.
    Indian J Dermatol 2017 Mar-Apr;62(2):158-167
    Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, City, Mexico; Division of Pathology, Instituto Nacional de Cancerología, Mexico City, Mexico.
    Background: Nonmycosis fungoides/Sézary syndrome (non-MF/SS) primary cutaneous lymphomas (PCL) are currently categorized under the 2005-World Health Organization/European Organization for Research and Treatment of Cancer (WHO-EORTC) classification for PCL. These differ in behavior from secondary cutaneous lymphomas (SCL) and to lymphomas limited to the oral cavity (primary oral lymphomas [POL]) both categorized under the 2016-WHO classification for lymphoid neoplasms.

    Aims: This study aims to report the first series of non-MF/SS PCL, SCL, and POL in a Mexican cohort, examine the applicability of current classification systems and compare our findings with those from foreign cohorts. Read More

    Influence of time interval from diagnosis to treatment on survival for oral cavity cancer: A nationwide cohort study.
    PLoS One 2017 7;12(4):e0175148. Epub 2017 Apr 7.
    Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan.
    Objectives: We aimed to explore the relationship between the time interval from diagnosis to treatment and survival of oral cavity squamous cell carcinoma patients.

    Materials And Methods: A population-based study was conducted between 2004 and 2010. Claims data of oral squamous cell carcinoma patients were retrieved from the Taiwan Cancer Registry Database. Read More

    Genome wide profiling in oral squamous cell carcinoma identifies a four genetic marker signature of prognostic significance.
    PLoS One 2017 6;12(4):e0174865. Epub 2017 Apr 6.
    Oral Cancer Research and Coordinating Centre, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
    Background: Cancers of the oral cavity are primarily oral squamous cell carcinomas (OSCCs). Many of the OSCCs present at late stages with an exceptionally poor prognosis. A probable limitation in management of patients with OSCC lies in the insufficient knowledge pertaining to the linkage between copy number alterations in OSCC and oral tumourigenesis thereby resulting in an inability to deliver targeted therapy. Read More

    Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge.
    Diagn Pathol 2017 Apr 5;12(1):32. Epub 2017 Apr 5.
    Postgraduate Program in Dentistry, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
    Background: Oral squamous cell carcinoma (OSCC) accounts over 90% of malignant neoplasms of the oral cavity. This pathological entity is associated to a high mortality rate that has remained unchanged over the past decades. Tumour-associated macrophages (TAMs) are believed to have potential involvement in OSCC progression. Read More

    Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma.
    Tumour Biol 2017 Apr;39(4):1010428317695527
    1 School of Dentistry, Federal University of Goiás, Goiânia, Brazil.
    To investigate hypoxia-induced factor-1 alpha expression in distinct oral squamous cell carcinoma subtypes and topographies and correlate with clinicopathological data. Hypoxia-induced factor-1 alpha expression was assessed by immunohistochemistry in 93 cases of OSCC. Clinical and histopathological data were reviewed from medical records. Read More

    High HMGA2 Expression Correlates with Reduced Recurrence-free Survival and Poor Overall Survival in Oral Squamous Cell Carcinoma.
    Anticancer Res 2017 04;37(4):1891-1899
    Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan, R.O.C.
    Background/aim: High-mobility group AT-hook 2 (HMGA2) is an architectural transcription factor that is expressed in many human neoplasms. Oral squamous cell carcinoma (OSCC) is one of the leading cancers in the world, particularly in Southeast Asia. In this study, the expression level of HMGA2 was determined on tissue microarray of OSCC and its correlation with prognosis of patients was studied. Read More

    Abiraterone Acetate for Metastatic Prostate Cancer in Patients With Suboptimal Biochemical Response to Hormone Induction.
    JAMA Oncol 2017 Nov 9;3(11):e170231. Epub 2017 Nov 9.
    Department of Urology, The University of Texas Health Science Center at San Antonio.
    Importance: Men with metastatic prostate cancer who have a poor response to initial androgen-deprivation therapy (ADT), as reflected by a prostate-specific antigen (PSA) level higher than 4.0 ng/mL after 7 months of ADT, have a poor prognosis, based on historical controls.

    Objective: To determine the efficacy of abiraterone acetate with prednisone in these high-risk patients with a suboptimal response to hormonal induction. Read More

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