9,454 results match your criteria Metastatic Carcinoma of the Skin


Avelumab in patients with previously treated metastatic Merkel cell carcinoma: long-term data and biomarker analyses from the single-arm phase 2 JAVELIN Merkel 200 trial.

J Immunother Cancer 2020 May;8(1)

Division of Dermatology, Department of Medicine, University of Washington Medical Center at South Lake Union, Seattle, Washington, USA.

Background: Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer associated with a high risk of metastasis. In 2017, avelumab (anti-programmed death-ligand 1 (PD-L1)) became the first approved treatment for patients with metastatic MCC (mMCC), based on the occurrence of durable responses in a subset of patients. Here, we report long-term efficacy and safety data and exploratory biomarker analyses in patients with mMCC treated with avelumab. Read More

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http://dx.doi.org/10.1136/jitc-2020-000674DOI Listing

Current Research in Melanoma and Aggressive Nonmelanoma Skin Cancer.

Facial Plast Surg 2020 Apr 15;36(2):200-210. Epub 2020 May 15.

Department of Dermatology, New York University Langone Health, New York, New York.

There have been several significant advances in cancer treatment in the last decade that are applicable to the treatment of melanoma and advanced nonmelanoma skin cancers. Among these are the development of immune checkpoint inhibitors targeting the programmed death protein-1 (PD-1)/programmed death legand-1 (PDL-1) axis, as well as targeted inhibitors of the BRAF/MEK signaling cascade in melanoma, and the hedgehog signaling pathway in basal cell carcinoma (BCC). These immune-based and targeted therapies have dramatically changed the treatment options for locally advanced and metastatic melanoma, Merkel's cell carcinoma, cutaneous squamous cell carcinoma (cSCC), and BCC. Read More

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http://dx.doi.org/10.1055/s-0040-1709118DOI Listing

Targeted Therapy and Traditional Chemotherapy in Melanoma and Cutaneous Squamous Cell Carcinoma.

Facial Plast Surg 2020 Apr 15;36(2):186-193. Epub 2020 May 15.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.

Cutaneous squamous cell carcinoma (cSCC) and melanoma encompass the majority of all malignant skin cancers. There has been an increase in their incidence globally in recent decades. In cases of high-risk, unresectable, or metastatic disease; or when patient factors or preferences limit the availability of conventional surgery or radiotherapy; or a systemic therapy is often warranted. Read More

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http://dx.doi.org/10.1055/s-0040-1709126DOI Listing

Ectopic ACTH Secretion Secondary to Metastatic Acinic Cell Carcinoma of the Parotid Gland: A Case Report and Review of Current Evidence for Systemic Therapy.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620918080

Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.

Acinic cell carcinoma is a rare, typically indolent, neoplasm that arises in the salivary glands. Metastatic disease is uncommon, occurring in around 10% of cases. We report the case of a 46-year-old male in whom the first sign of disseminated disease was increased skin pigmentation due to paraneoplastic Cushing's syndrome. Read More

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http://dx.doi.org/10.1177/2324709620918080DOI Listing

The use of cisplatin electrochemotherapy in non-melanoma skin cancers: A single-center study.

Dermatol Ther 2020 May 9:e13547. Epub 2020 May 9.

Department of Surgery, University of Perugia, Italy.

Background: Electrochemotherapy (ECT) is a well-known non-conventional skin cancer ablative method that was shown to be safe and effective for treating both locoregional disease spreading and disseminated cutaneous and subcutaneous lesions from different type of cancer. The most common medications used are bleomycin and cisplatin. In the last years many studies were performed on ECT, lead it to be a valid therapeutic option in many international guidelines. Read More

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http://dx.doi.org/10.1111/dth.13547DOI Listing

[Recurrence-Free Survival after Repeated Resections for Metastatic Inguinal Tumor in Colorectal Mucinous Adenocarcinoma-A Case Report].

Gan To Kagaku Ryoho 2020 Jan;47(1):123-125

Dept. of Surgery, Funabashi Municipal Medical Center.

A 79-year-old male presented with right inguinal mass and right leg pain. Laparoscopic right hemicolectomy was performed for transverse colon cancer(type 1, muc, pSS, pN1a, pStage Ⅲa)3 years and 6 months ago. We resected the mass located in the spermatic cord and reconstructed it using the Direct Kugel Patch. Read More

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January 2020

GIANT BASAL CELL CARCINOMA ON THE FOREHEAD AND WHY WE SHOULD PREVENT THEM - CASE REPORT.

Acta Chir Plast 2020 ;61(1-4):24-27

Basal cell carcinoma (BCC) is the most prevalent malignancy, with rising incidence worldwide. Despite its naturally slow growth and initially low metastatic potential, it can cause significant morbidity and mortality when unrecognized, inadequately treated or poorly followed up. Authors present the case of a 61-year-old male with a 7-year history of multiple incomplete excisions of a “simple” BCC on the forehead. Read More

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January 2020

LSD1: a viable therapeutic target in cutaneous squamous cell carcinoma?

Expert Opin Ther Targets 2020 May 7:1-8. Epub 2020 May 7.

Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

: Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer; it can be locally invasive and metastatic. cSCC is an immense clinical and economic problem given its sheer incidence and potential morbidity and mortality, particularly in the elderly and immunocompromised. Epigenetics has emerged as one of the most exciting areas of human biology, impacting virtually all areas of cellular physiology. Read More

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http://dx.doi.org/10.1080/14728222.2020.1762175DOI Listing

Rapid Rehabilitation With Skin-Muscle Sparing Orbital Exenteration: A Single-Center Series.

Ophthalmic Plast Reconstr Surg 2020 May 4. Epub 2020 May 4.

Adnexal Service, Moorfields Eye Hospital, London, United Kingdom.

Aims: To examine the features and clinical management of patients who underwent skin-muscle sparing orbital exenteration in a tertiary referral center.

Patients And Method: Retrospective case-note review for patients undergoing skin-muscle sparing orbital exenteration at Moorfields Eye Hospital between 1997 and 2012. Patient demographics, clinical features, histopathology, clearance, surgery, adjuvant therapy, and outcomes were analyzed. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001677DOI Listing

Delta-like Protein 3 Expression and Targeting in Merkel Cell Carcinoma.

Oncologist 2020 May 5. Epub 2020 May 5.

Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA.

Purpose: Delta-like protein 3 (DLL3) is being developed as a predictive biomarker for DLL3-targeting antibody-drug conjugate and other therapies. Given the neuroendocrine features of Merkel cell carcinoma (MCC), we sought to evaluate DLL3 expression and its role in MCC.

Experimental Design: Formalin-fixed and paraffin-embedded MCC cases were consecutively selected. Read More

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http://dx.doi.org/10.1634/theoncologist.2019-0877DOI Listing

A case report of carcinoma of uterine cervix throwing heterochronous metastasis to the skin, spleen, and pancreas: the role of multimodality treatment approach.

J Egypt Natl Canc Inst 2019 Dec 16;31(1). Epub 2019 Dec 16.

Royal Cancer Institute and Research Centre, Kanpur, Uttar Pradesh, India.

Background: Cancer of cervix often fails locally and/or within the pelvis. One to two percent of cervical squamous cell carcinoma patients have lung metastases at presentation, and 5-35% develop pulmonary metastases later on. Common sites of metastases are the liver, bone, and bowel. Read More

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http://dx.doi.org/10.1186/s43046-019-0009-9DOI Listing
December 2019

Synchronous high-grade bladder carcinoma associated with chronic lymphocytic leukemia: A rare entity in Indian literature.

J Cancer Res Ther 2020 Jan-Mar;16(1):180-182

Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) is one of the common lymphoproliferative disorders with an increased risk of developing subsequent neoplasms of epithelial and mesenchymal origin. The decreased immunity and B-cell dysfunction in CLL probably accounts for this emergence of secondary malignancy. Breast, brain, skin and prostate tumors have been reported as usual coincident malignancies of CLL, while in occasional cases CLL may occur with malignancies of other solid organs, such as skin, lung, heart, and prostate. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_642_16DOI Listing

Validation of a 40-Gene Expression Profile Test to Predict Metastatic Risk in Localized High-Risk Cutaneous Squamous Cell Carcinoma.

J Am Acad Dermatol 2020 Apr 25. Epub 2020 Apr 25.

University of California San Francisco, San Francisco, CA. Electronic address:

Background: Current staging systems for cutaneous squamous cell carcinoma (cSCC) have limited positive predictive value (PPV) for identifying patients who will experience metastasis.

Objective: To develop and validate a gene expression profile (GEP) test for predicting risk for metastasis in localized, high-risk cSCC with the goal of improving risk-directed patient management.

Methods: Archival formalin-fixed paraffin-embedded primary cSCC tissue and clinicopathologic data (n=586) were collected from 23 independent centers in a prospectively designed study. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.088DOI Listing

Endocrine mucin-producing sweat gland carcinoma - newly described skin appendageal tumours.

Malays J Pathol 2020 Apr;42(1):111-114

Universiti Putra Malaysia, Faculty of Medicine and Health Sciences, Department of Pathology, 43400 Serdang, Selangor, Malaysia.

Introduction: Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a recently described adnexal tumour with a predilection for the face particularly the eye-lids. Considered to be a precursor lesion of mucinous adenocarcinoma, it may represent part of a morphological spectrum. We described a case of this entity, which we believe is the first case to be reported in Malaysia. Read More

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Safety and Efficacy of Apatinib Monotherapy for Unresectable, Metastatic Esophageal Cancer: A Single-Arm, Open-Label, Phase II Study.

Oncologist 2020 Apr 27. Epub 2020 Apr 27.

Department of Integrative Oncology, Tianjin Medical University Cancer Institute and Hospital and Key Laboratory of Cancer Prevention and Therapy, Tianjin, People's Republic of China.

Lessons Learned: Patient compliance with the oral dosage treatment was good, with no need for hospitalization. Patients with tracheal and esophageal fistulas can take crushed apatinib by nutrient tube, with the same bioavailability and efficacy. Apatinib may be an effective and safe second- or further-line treatment for advanced esophageal cancer. Read More

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http://dx.doi.org/10.1634/theoncologist.2020-0310DOI Listing

Gefitinib as neoadjuvant therapy for resectable stage II-IIIA non-small cell lung cancer: A phase II study.

J Thorac Cardiovasc Surg 2020 Mar 19. Epub 2020 Mar 19.

Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Institute of Thoracic Oncology, Fudan University, Shanghai, China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

Introduction: Currently, limited data on tyrosine kinase inhibitors as neoadjuvant therapy exist. This prospective study aimed to investigate the efficacy and safety of preoperative gefitinib in patients with stage II-IIIA operable non-small cell lung cancer (NSCLC).

Methods: This was a single-arm, phase II trial performed in the Shanghai Cancer Center. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2020.02.131DOI Listing
March 2020
4.168 Impact Factor

Therapeutic effects of ephrin B receptor 2 inhibitors screened by molecular docking on cutaneous squamous cell carcinoma.

J Dermatolog Treat 2020 Apr 27:1-7. Epub 2020 Apr 27.

Department of Surgery, Lanzhou University Second Hospital, Lanzhou, China.

Cutaneous squamous cell carcinoma (CSCC) is the most known form type of metastatic skin cancer. Activation of ephrin B receptor 2 (EphB2) signaling can promote the metastasis, invasion, and angiogenesis of CSCC cells. Therefore, EphB2 may act as a therapeutic target for CSCC. Read More

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http://dx.doi.org/10.1080/09546634.2020.1756201DOI Listing

Anal canal adenocarcinoma with pagetoid spread and inguinal lymph node metastasis treated with preoperative chemoradiotherapy: A case report.

Mol Clin Oncol 2020 Jun 16;12(6):529-532. Epub 2020 Mar 16.

Department of Surgical Oncology, The University of Tokyo, Tokyo 113-8655, Japan.

Perianal Paget's disease is a rare condition, which is not usually accompanied by cancer. Here, a case of anal canal carcinoma with pagetoid spread and inguinal lymph node metastasis, which exhibited a significant response to preoperative chemoradiotherapy (CRT), is presented. A 58-year-old woman was admitted to The University of Tokyo Hospital with a complaint of discomfort around the anus. Read More

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http://dx.doi.org/10.3892/mco.2020.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179386PMC

Recent and Emerging Therapies for Cutaneous Squamous Cell Carcinomas of the Head and Neck.

Curr Treat Options Oncol 2020 Apr 23;21(5):37. Epub 2020 Apr 23.

Cleveland Clinic Foundation, Cleveland, OH, USA.

Opinion Statement: Cutaneous squamous cell carcinoma (cSCC) of the head and neck is typically managed with Mohs Micrographic Surgery (MMS) for cosmetic reasons. MMS also improves oncologic outcomes for high-risk tumors. Patients with certain high-risk subsets of the disease also benefit from adjuvant radiation therapy. Read More

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http://dx.doi.org/10.1007/s11864-020-00739-7DOI Listing

Neoadjuvant Nivolumab for Patients With Resectable Merkel Cell Carcinoma in the CheckMate 358 Trial.

J Clin Oncol 2020 Apr 23:JCO2000201. Epub 2020 Apr 23.

University of Washington, Seattle Cancer Care Alliance, Seattle, WA.

Purpose: Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer commonly driven by the Merkel cell polyomavirus (MCPyV). The programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) immunosuppressive pathway is often upregulated in MCC, and advanced metastatic MCC frequently responds to PD-1 blockade. We report what we believe to be the first trial of anti-PD-1 in the neoadjuvant setting for resectable MCC. Read More

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http://dx.doi.org/10.1200/JCO.20.00201DOI Listing
April 2020
18.428 Impact Factor

[Eccrine carcinoma: a diagnostic pitfall].

Ned Tijdschr Geneeskd 2020 Mar 19;164. Epub 2020 Mar 19.

Ziekenhuis Gelderse Vallei, afd. Chirurgie, Ede.

Background: The eccrine carcinoma is a rare form of skin adnexal malignancy, usually presenting as a locally invasive, solitary lesion in the head and neck region. Histopathologically and immunohistochemically, eccrine carcinomas are difficult to differentiate from cutaneous metastases of breast carcinomas. Unlike treatment of cutaneous metastasis, treatment of a solitary eccrine carcinoma entails excision, generally without systematic therapy. Read More

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Clear cell lesions in pathology: Histomorphologic approach to diagnosis.

Indian J Pathol Microbiol 2020 Apr-Jun;63(2):177-187

O and G, Consultant, Cuttack, Odisha, India.

There has been remarkable progress in the field of surgical pathology; however, histomorphology has remained the most important and essential tool of the surgical pathologist in everyday practice till now. It is surprising that the hematoxylin-eosin (H and E) stain, introduced more than a century ago, has still remained the gold standard stain for histological examination and diagnosis of human diseases. Besides different findings or clues observed in histopathology sections like inclusions, granules, grooving, globules, halo, or clearing, which would enable the pathologist to provide a precise and accurate diagnosis; observation of clear cells is one of the important findings and clue for reporting. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_791_19DOI Listing

Results of a randomized, double-blind phase II clinical trial of NY-ESO-1 vaccine with ISCOMATRIX adjuvant versus ISCOMATRIX alone in participants with high-risk resected melanoma.

J Immunother Cancer 2020 Apr;8(1)

Ludwig Institute for Cancer Research Austin Branch, Heidelberg, Victoria, Australia.

Background: To compare the clinical efficacy of New York Esophageal squamous cell carcinoma-1 (NY-ESO-1) vaccine with ISCOMATRIX adjuvant versus ISCOMATRIX alone in a randomized, double-blind phase II study in participants with fully resected melanoma at high risk of recurrence.

Methods: Participants with resected stage IIc, IIIb, IIIc and IV melanoma expressing NY-ESO-1 were randomized to treatment with three doses of NY-ESO-1/ISCOMATRIX or ISCOMATRIX adjuvant administered intramuscularly at 4-week intervals, followed by a further dose at 6 months. Primary endpoint was the proportion free of relapse at 18 months in the intention-to-treat (ITT) population and two per-protocol populations. Read More

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http://dx.doi.org/10.1136/jitc-2019-000410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204806PMC

Bilateral Fascia Lata Flap: An Alternative for Massive Abdominal Wall Defect Repair.

Plast Reconstr Surg Glob Open 2020 Feb 28;8(2):e2577. Epub 2020 Feb 28.

American British Cowdray Medical Center I.A.P., Mexico City, Mexico.

The abdominal wall represents a unique structure of dermo-myotendinous conformation that is considered a surgical challenge. The musculocutaneous pedicled flap, using tensor fasciae latae muscle (TFL), is a technique of abdominal wall repair, and it is becoming a more frequent reconstructive procedure. It is a well-suited procedure because it provides both a semirigid fascia layer and adequate skin coverage. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159935PMC
February 2020

Global incidence of incomplete surgical excision in adult patients with non-melanoma skin cancer: study protocol for a systematic review and meta-analysis of observational studies.

Syst Rev 2020 Apr 17;9(1):83. Epub 2020 Apr 17.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Roosevelt Drive, Oxford, OX3 7LD, UK.

Background: Non-melanoma skin cancer, which includes basal cell carcinoma and cutaneous squamous cell carcinoma, is the commonest malignancy worldwide. The mainstay of treatment is surgical excision. Despite this being an exceptionally common procedure, it is not known what the accepted standard is for incomplete excision. Read More

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http://dx.doi.org/10.1186/s13643-020-01350-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164252PMC

Recurrent Small Cell Carcinoma of the Lung With Cutaneous Metastasis in Breast.

Oncology (Williston Park) 2020 Apr 10;34(4). Epub 2020 Apr 10.

Lung cancer remains the leading cause of cancer-related deaths and the second leading cause of new cancer cases in the United States. Although more commonly involving hilar nodes, the liver, adrenal glands, bones, and the brain, lung cancer can metastasize to almost any organ. Metastases, although rare in the skin may be the first sign of a lung cancer or cutaneous metastases may present as a sign of recurrent disease. Read More

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Unexpected response to palliative radiotherapy for subcutaneous metastases of an advanced small cell pancreatic neuroendocrine carcinoma: a case report of two different radiation schedules.

BMC Cancer 2020 Apr 15;20(1):311. Epub 2020 Apr 15.

Interdisciplinary Department of Medicine, Section of Radiology and Radiation Oncology, University of Bari "Aldo Moro", P.zza Giulio Cesare nr.11, 70124, Bari, Italy.

Background: Skin metastases from pancreatic neuroendocrine carcinoma (PNEC) are rare and their palliative treatment is challenging. We report our experience in the multimodal management of one of the few reported cases of metastatic PNEC with multiple visceral and subcutaneous secondary lesions, focusing on the effectiveness of palliative radiotherapy for skin metastases.

Case Presentation: A 61-years old woman affected by a metastatic PNEC - with subcutaneous growing and bleeding secondary lesions (at the scalp, right scapular region and at the back of the left thoracic wall, respectively) - obtained a successful control of visceral metastases with the use of chemotherapy and an unexpected local response of her skin metastases with palliative radiotherapy. Read More

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http://dx.doi.org/10.1186/s12885-020-06845-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161181PMC

Merkel cell carcinoma of lymph nodes without a skin primary tumor: a potential metastatic neoplasia associated with a brisk immune response.

J Am Acad Dermatol 2020 Apr 9. Epub 2020 Apr 9.

UMR INRA ISP 1282, team"Biologie des infections à polyomavirus", Université de Tours, Faculté des Sciences Pharmaceutiques 31, avenue Monge 37200 Tours, France; Dermatology Department, Université Francois Rabelais, CHU de Tours, avenue de la République, 37170, Chambray-les-tours, France.

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http://dx.doi.org/10.1016/j.jaad.2020.03.108DOI Listing

A cancer stem cell-like phenotype is associated with miR-10b expression in aggressive squamous cell carcinomas.

Cell Commun Signal 2020 Apr 10;18(1):61. Epub 2020 Apr 10.

EB House Austria, Research Program for Molecular Therapy of Genodermatoses, Department of Dermatology & Allergology, University Hospital of the Paracelsus Medical University, 5020, Salzburg, Austria.

Background: Cutaneous squamous cell carcinomas (cSCC) are the primary cause of premature deaths in patients suffering from the rare skin-fragility disorder recessive dystrophic epidermolysis bullosa (RDEB), which is in marked contrast to the rarely metastasizing nature of these carcinomas in the general population. This remarkable difference is attributed to the frequent development of chronic wounds caused by impaired skin integrity. However, the specific molecular and cellular changes to malignancy, and whether there are common players in different types of aggressive cSCCs, remain relatively undefined. Read More

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http://dx.doi.org/10.1186/s12964-020-00550-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146875PMC

Risk Factors for Keratinocyte Carcinoma in Recipients of Allogeneic Hematopoietic Cell Transplants.

JAMA Dermatol 2020 Apr 8. Epub 2020 Apr 8.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota.

Importance: Allogeneic hematopoietic cell transplant (alloHCT) is known to increase the risk for keratinocyte carcinoma. The extent to which host characteristics, including pigmentary phenotype and UV radiation exposure, contribute is unknown.

Objective: To identify and validate independent risk factors for keratinocyte carcinoma after alloHCT, including those associated with the transplant and the host. Read More

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http://dx.doi.org/10.1001/jamadermatol.2020.0559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142796PMC

The Role of Collagen XVII in Cancer: Squamous Cell Carcinoma and Beyond.

Front Oncol 2020 19;10:352. Epub 2020 Mar 19.

Skin Immunology Laboratory, Department of Dermatology, University of Illinois at Chicago, Chicago, IL, United States.

Alterations in the extracellular matrix (ECM) likely facilitate the first steps of cancer cell metastasis and supports tumor progression. Recent data has demonstrated that alterations in collagen XVII (BP180), a transmembrane protein and structural component of the ECM, can have profound effects on cancer invasiveness. Collagen XVII is a homotrimer of three α1 (XVII) chains. Read More

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http://dx.doi.org/10.3389/fonc.2020.00352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096347PMC

Prevalence of cancers diagnosed in Jamhuriyat Hospital, Kabul, Afghanistan.

Heliyon 2020 Mar 20;6(3):e03603. Epub 2020 Mar 20.

Centre for Radiation and Nuclear Physics, University of Surrey, Guildford, Surrey, GU2 7XH, UK.

Backgrounds: Throughout the world, there exists a clear need for the maintenance of cancer statistics, forming an essential part of any rational programme of cancer control, health-care planning, etiological research, primary and secondary prevention, benefiting both individuals and society. The present work reports only on the prevalence of cancers in the Oncology Department of Jamhuriyat Hospital, Kabul, Afghanistan following several decades of war.

Materials And Methods: A quantitative retrospective cross-sectional study was conducted using the medical records of patients diagnosed and treated from October 2015 to December 2017. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096744PMC

Cytotoxic-mediated spontaneous regression of inflammatory cutaneous metastases of breast carcinoma.

Authors:
Carlo Tomasini

J Cutan Pathol 2020 Mar 28. Epub 2020 Mar 28.

IRCCS Fondazione Policlinico San Matteo, Department of Medical-Surgical, Diagnostic and Pediatric Sciences, Dermatologic Clinic, University of Pavia School of Medicine, Pavia, Italy.

Spontaneous regression (SR) of cancer is a rare but well-documented biological phenomenon, which is even rarer in the context of metastatic breast carcinoma. Different mechanisms of SR are still under debate, including immune-mediated response. We herein report a case of the SR of intralymphatic cutaneous metastases of a breast carcinoma with spontaneously-induced T-cell-mediated cytotoxic response. Read More

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http://dx.doi.org/10.1111/cup.13694DOI Listing

Aggressive behavior of Her-2 positive colloid breast carcinoma: A case report in a metastatic breast cancer.

Ann Med Surg (Lond) 2020 Apr 10;52:48-52. Epub 2020 Mar 10.

Division of Surgical Oncology, Department of Surgery, Dr Sardjito Hospital, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia.

Introduction: Colloid breast carcinoma is a rare form of invasive ductal cancer characterized by large amount of mucous deposition. It is considered as an indolent cancer that usually affects older women. Colloid breast carcinoma generally expresses estrogen and progesterone receptors but negative for Her-2. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082430PMC

Immunologic Characteristics of Nonmelanoma Skin Cancers: Implications for Immunotherapy.

Am Soc Clin Oncol Educ Book 2020 Mar;40:1-10

Division of Medical Oncology, University of Washington, Seattle, WA.

In this review, we summarize the immunology of nonmelanoma skin cancers (NMSCs) and the clinical data with immunotherapy in this heterogeneous group of cancers that include basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (CSCC), and Merkel cell carcinoma (MCC). NMSCs are exceedingly common, and their treatment consumes substantial health care resources. Annual global mortality from NMSCs is comparable to that from malignant melanoma. Read More

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http://dx.doi.org/10.1200/EDBK_278953DOI Listing

[Effects of an unconventional skin cancer prevention campaign : Impacts on the sun protection behavior of outdoor workers].

Hautarzt 2020 Mar 23. Epub 2020 Mar 23.

Fakultät für Medizin, Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Biedersteiner Str. 29, 80802, München, Deutschland.

Background: The disease burden of actinic keratoses and keratinocyte carcinoma can be reduced by primary and secondary prevention. However, these measures are often poorly received, especially among the high-risk group of outdoor workers.

Objectives: The aim of this follow-up study was to investigate whether an improvement in sun protection and awareness of skin changes could be observed among the study population, especially outdoor workers, one year after a prevention campaign focusing on this topic. Read More

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http://dx.doi.org/10.1007/s00105-020-04574-7DOI Listing

Risk factors for recurrent and metastatic cutaneous squamous cell carcinoma in immunocompromised patients.

J Am Acad Dermatol 2020 Mar 18. Epub 2020 Mar 18.

Department of Dermatology, NYU Langone Health, New York, NY.

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http://dx.doi.org/10.1016/j.jaad.2020.03.027DOI Listing
March 2020
4.449 Impact Factor

Most Common Pathway of Metastasis of Rectal Signet Ring Cell Carcinoma to the Skin: Hematogenous.

Cureus 2020 Feb 5;12(2):e6890. Epub 2020 Feb 5.

Internal Medicine, AdventHealth, Orlando, USA.

Liver represents the most common site of metastasis in patients with advanced colorectal cancer (CRC). Cutaneous metastasis is uncommon and has been documented only in 3% of patients. Most cutaneous metastases demonstrate typical histological features of adenocarcinoma, such as glandular formation and mucin production. Read More

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http://dx.doi.org/10.7759/cureus.6890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058390PMC
February 2020

Phase 2 study of pembrolizumab in patients with advanced rare cancers.

J Immunother Cancer 2020 Mar;8(1)

Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: Patients with advanced rare cancers have poor prognosis and few treatment options. As immunotherapy is effective across multiple cancer types, we aimed to assess pembrolizumab (programmed cell death 1 (PD-1) inhibitor) in patients with advanced rare cancers.

Methods: In this open-label, phase 2 trial, patients with advanced rare cancers whose tumors had progressed on standard therapies, if available, within the previous 6 months were enrolled in nine tumor-specific cohorts and a 10th cohort for other rare histologies. Read More

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http://dx.doi.org/10.1136/jitc-2019-000347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078933PMC

Kidney retransplantation after anti-programmed cell death-1 (PD-1)-related allograft rejection.

Am J Transplant 2020 Mar 17. Epub 2020 Mar 17.

Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

In this report, we describe the first kidney retransplantation performed after anti-programmed cell death-1 (PD-1)-related allograft rejection. In 2014, we administered pembrolizumab (anti-PD-1) for ~9 months to a 57-year-old kidney transplant recipient with metastatic cutaneous squamous cell carcinoma (CSCC). The patient experienced both a complete antitumor response and T cell-mediated allograft rejection requiring reinitiation of hemodialysis. Read More

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http://dx.doi.org/10.1111/ajt.15856DOI Listing

miRNAs in the Diagnosis and Prognosis of Skin Cancer.

Front Cell Dev Biol 2020 28;8:71. Epub 2020 Feb 28.

Department of Pathology, Colentina Clinical Hospital, Bucharest, Romania.

Skin cancer is, at present, the most common type of malignancy in the Caucasian population. Its incidence has increased rapidly in the last decade for both melanoma and non-melanoma skin cancer. Differential expression profiles of microRNAs (miRNAs) have been reported for a variety of different cancers, including skin cancers. Read More

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http://dx.doi.org/10.3389/fcell.2020.00071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058916PMC
February 2020

The Roles of lncRNA in Cutaneous Squamous Cell Carcinoma.

Front Oncol 2020 28;10:158. Epub 2020 Feb 28.

Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.

Cutaneous squamous cell carcinoma derives from keratinocytes and is the second most common cause of non-melanoma skin cancer. Cutaneous squamous cell carcinoma (cSCC) develops rapidly and is also the leading cause of death in non-melanoma cancers. Lymph node metastasis occurs in 5% of cSCC patients, and some patients may even metastasize to the viscera. Read More

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http://dx.doi.org/10.3389/fonc.2020.00158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059100PMC
February 2020

Eccrine Porocarcinoma with Zosteriform Metastasis.

Cureus 2020 Feb 4;12(2):e6873. Epub 2020 Feb 4.

Surgery, South Colombian University, Neiva, COL.

Eccrine porocarcinoma is a rare malignant tumor that develops in the eccrine glands, appearing as a primary tumor, or by malignant transformation of an eccrine poroma. It is a carcinoma with high metastatic and recurrent potential; it has the same incidence in both sexes, and mainly affects the elderly. Its diagnosis, rather than clinical, is histological, and due to the rarity of the disease, it is a pathological challenge. Read More

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http://dx.doi.org/10.7759/cureus.6873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053679PMC
February 2020

Male axillary accessory breast cancer: A case report.

Medicine (Baltimore) 2020 Mar;99(11):e19506

General Surgery, Qingdao West Coast New Area Central Hospital, Qingdao, China.

Rationale: Accessory breast cancer is extremely rare among all cancerous diseases, especially in male patients. There were only few male axillary accessory breast cancer cases that have been reported in scientific literatures so far. Hereby, we would like to discuss a case of male axillary accessory breast cancer found in our hospital. Read More

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http://dx.doi.org/10.1097/MD.0000000000019506DOI Listing

Secondary prevention of UV-induced skin cancer: development and pilot testing of an educational patient counseling approach for individual sun protection as standard procedure of patient care.

Int Arch Occup Environ Health 2020 Mar 11. Epub 2020 Mar 11.

Department of Dermatology, Environmental Medicine and Health Theory, Institute for Health Research and Education, University of Osnabrück, Osnabrück, Germany.

Objective: To outline the development and pilot testing of a patient counseling approach for individual sun protection for patients in outdoor professions diagnosed with squamous cell carcinoma or multiple actinic keratosis due to solar UV radiation. This is a secondary prevention measure as part of the standard procedure of patient care by the respective statutory accident insurance.

Methods: Results of guideline-based qualitative interviews with seven outdoor workers and a search of literature formed the basis for the counseling approach, which was compiled in a manual. Read More

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http://dx.doi.org/10.1007/s00420-020-01532-7DOI Listing

Merkel Cell Carcinoma and Diagnostic Experience in a Reference Hospital: A Case Series.

Case Rep Med 2020 19;2020:8391510. Epub 2020 Feb 19.

Department of Pathology and Laboratories, Fundación Santa Fe de Bogotá, Bogotá, Colombia.

Merkel cell carcinoma (MCC) is a rare poorly differentiated neuroendocrine tumor, usually located in sun-exposed skin, with aggressive behavior and with high recurrence risk and metastatic disease. In Latin America, case series have been published, and it does not exceed 32 patients in 10 years, and in Colombia, there are case reports. We present a descriptive retrospective cross-sectional study in patients diagnosed with MCC in the Department of Pathology and Laboratories at the University Hospital Fundación Santa Fe de Bogotá(FSFB) between January 2003 and December 2018. Read More

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http://dx.doi.org/10.1155/2020/8391510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049825PMC
February 2020

Individualized comprehensive treatment for lung adenocarcinoma with multiple skin and bilateral breast metastasis: A case report.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Jan;45(1):102-108

Department of Oncology, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Lung adenocarcinoma is a malignant tumor that is prone to distant metastasis. Common metastatic sites are brain, adrenal gland, liver, bone, and so on. Skin soft tissue metastasis is unusual, and breast metastasis is even rarer. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2020.190232DOI Listing
January 2020

Determination of high-risk HPV status of head and neck squamous cell carcinoma using the Roche cobas HPV test on cytologic specimens and acellular supernatant fluid.

Cancer Cytopathol 2020 Mar 4. Epub 2020 Mar 4.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: High-risk human papillomavirus-positive (hrHPV+) oropharyngeal squamous cell carcinomas comprise a subset of head and neck squamous cell carcinomas (HNSCCs) with a distinct biology and prognosis. Commonly, the diagnosis of HNSCC is rendered on fine-needle aspiration (FNA). Because cell blocks may be insufficient for determining HPV status using microscopy-based techniques, the ability of liquid-based assays was examined in the current study. Read More

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http://dx.doi.org/10.1002/cncy.22258DOI Listing

Efficacy and tolerability of nimotuzumab in combination with chemotherapy in recurrent and metastatic squamous cell carcinoma of head and neck at a cancer center in Northern India.

Indian J Cancer 2020 Jan-Mar;57(1):76-83

Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Introduction: Squamous cell carcinoma of head and neck (SCCHN) account for approximately 30-33% of all cancer and the median survival for recurrent and metastatic(R/M) SCCHN remains less than 1 year despite modern advances in therapy. Chemotherapy, usually single agent remains the backbone of therapy in these patients. EGFR antibodies are being used in (R/M) SCCHN. Read More

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http://dx.doi.org/10.4103/ijc.IJC_469_18DOI Listing

Management Recommendations for Merkel Cell Carcinoma-A Danish Perspective.

Cancers (Basel) 2020 Feb 28;12(3). Epub 2020 Feb 28.

Department of Plastic Surgery, Herlev & Gentofte Hospital, Department of Clinical Medicine, Copenhagen University, 2730 Herlev, Denmark.

Merkel cell carcinoma (MCC) is a rare malignant neuroendocrine carcinoma of the skin with a poor prognosis and an apparent increase in incidence. Due to its rarity, evidence-based guidelines are limited, and there is a lack of awareness among clinicians. This review constitutes the consensus management recommendations developed by the Danish MCC expert group and is based on a systematic literature search. Read More

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http://dx.doi.org/10.3390/cancers12030554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139291PMC
February 2020