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    8035 results match your criteria Metastatic Carcinoma of the Skin

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    Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive patients with type 2 diabetes (SUSTAIN 4): a randomised, open-label, parallel-group, multicentre, multinational, phase 3a trial.
    Lancet Diabetes Endocrinol 2017 Mar 23. Epub 2017 Mar 23.
    Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands. Electronic address:
    Background: Several pharmacological treatment options are available for type 2 diabetes; however, many patients do not achieve optimum glycaemic control and therefore new therapies are necessary. We assessed the efficacy and safety of semaglutide, a glucagon-like peptide-1 (GLP-1) analogue in clinical development, compared with insulin glargine in patients with type 2 diabetes who were inadequately controlled with metformin (with or without sulfonylureas).

    Methods: We did a randomised, open-label, non-inferiority, parallel-group, multicentre, multinational, phase 3a trial (SUSTAIN 4) at 196 sites in 14 countries. Read More

    Metastatic neuroendocrine carcinoma in the skin.
    Dermatol Online J 2017 Jan 15;23(1). Epub 2017 Jan 15.
    Department of Dermatology, University of Texas McGovern Medical School at Houston.
    Cutaneous metastases secondary to neuroendocrinetumors are rare. Herein we report a case of a 75-yearoldwoman who presented with a rare cutaneousmetastatic disease. She was previously diagnosed withmetastatic neuroendocrine carcinoma of unknownprimary, with metastases to liver, lung, and bone. Read More

    Signet-ring Cells in the Skin: A Case of Late-onset Cutaneous Metastasis of Gastric Carcinoma and a Brief Review of Histological Approach.
    Dermatol Reports 2016 Jun 4;8(1):6819. Epub 2017 Jan 4.
    Department of Dermatology and Venerology, Kirikkale University , Turkey.
    Up to 10% of patients with visceral malignancies develop skin metastases during their clinical course and these metastases constitute about 2% of all skin cancers. Skin metastasis may be the first sign of a clinically silent visceral cancer or represent recurrence of an internal malignancy. In both situations, they are associated with poor prognosis, which can partly be attributed to underdiagnosis. Read More

    Complement Component C3 and Complement Factor B Promote Growth of Cutaneous Squamous Cell Carcinoma.
    Am J Pathol 2017 Mar 16. Epub 2017 Mar 16.
    Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland; MediCity Research Laboratory, University of Turku, Turku, Finland. Electronic address:
    Cutaneous squamous cell carcinoma (cSCC) is one of the most common metastatic skin cancers with increasing incidence. We examined the roles of complement component C3 and complement factor B (CFB) in the growth of cSCC. Analysis of cSCC cell lines (n = 8) and normal human epidermal keratinocytes (n = 11) with real-time quantitative PCR and Western blotting revealed up-regulation of C3 and CFB expression in cSCC cells. Read More

    Ovarian carcinoma presenting as cutaneous nasal metastasis.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):101-104
    Hospital Garcia de Orta - Almada, Portugal.
    Metastatic ovarian cancer uncommonly presents with skin metastasis. When present, skin metastases of ovarian cancer are usually localized in the vicinity of the primary tumor. We report a case of a 58-year-old woman with a rapid growing erythematous, well-defined nodule localized on the left nasal ala. Read More

    Reassessing the clinical spectrum associated with Hereditary Leiomyomatosis and Renal Cell Carcinoma syndrome in French FH mutation carriers.
    Clin Genet 2017 Mar 16. Epub 2017 Mar 16.
    Département de Médecine Oncologique, Gustave Roussy, Université Paris-Saclay, Villejuif, F-94805, France.
    We addressed uncertainties regarding Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC) by exploring all French cases, representing the largest series to date. Fumarate Hydratase (FH) germline testing was performed with Sanger sequencing and qPCR/MLPA. Enzyme activity was measured when necessary. Read More

    Simultaneous vascularized bony reconstruction of the maxilla and mandible using a single fibula: A case report.
    Microsurgery 2017 Mar 13;37(3):243-247. Epub 2017 Mar 13.
    Department of Plastic Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
    Simultaneous maxillary and mandibular reconstruction is exceedingly rare. These are complicated cases, requiring consideration of multiple variables: defect components, donor site morbidity, recipient vessels, and so forth. We describe a unique case of secondary maxillary/mandibular reconstruction in a 59-year-old male. Read More

    Bilateral Lymphatic Spread of Metastatic Basal Cell Carcinoma.
    Plast Reconstr Surg Glob Open 2016 Dec 23;4(12):e1182. Epub 2016 Dec 23.
    Department of Surgery, Division of Surgical Oncology, 987400 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, Neb.
    Herein, we report a case of a patient with an abnormal skin lesion that remained unchecked by medical professionals for approximately 20 years. Upon physical examination in the emergency department for a fractured hip, an infiltrative mass was incidentally discovered. The neoplasm was noted to have progressed from an eraser-sized mass to a 3. Read More

    mFOLFOX6 Plus Panitumumab Versus 5-FU/LV Plus Panitumumab After Six Cycles of Frontline mFOLFOX6 Plus Panitumumab: A Randomized Phase II Study of Patients With Unresectable or Advanced/Recurrent, RAS Wild-type Colorectal Carcinoma (SAPPHIRE)-Study Design and Rationale.
    Clin Colorectal Cancer 2017 Mar 1. Epub 2017 Mar 1.
    Tokai Central Hospital, Kakamigahara, Japan.
    Background: In Japan, oxaliplatin (OXA)/5-fluorouracil (5-FU)/leucovorin (LV)-the mFOLFOX6 regimen-is the most frequently used first-line chemotherapy backbone for metastatic colorectal cancer. However, peripheral nerve disorders caused by OXA during mFOLFOX6 therapy can decrease patients' quality of life. OXA can be safely discontinued from a FOLFOX regimen after 6 cycles during first-line therapy. Read More

    Planning study for Merkel cell carcinoma based on the relapse pattern.
    Radiother Oncol 2017 Mar 8. Epub 2017 Mar 8.
    Radiation Oncology, Charité University Medicine Berlin, Germany.
    Purpose: To develop a technique for radiation (RT) of in-transit path ways (IT) in Merkel cell carcinoma.

    Method: In the planning study, IT were ink-marked on the skin during sentinel lymphscintigraphy and wire-marked in planning-CT. Pre- and post-operative planning-CTs were acquired. Read More

    New developments in the biology and the treatment of metastatic Merkel cell carcinoma.
    Curr Opin Oncol 2017 Mar 9. Epub 2017 Mar 9.
    aDepartment of Dermatology, University of Lübeck, Lübeck bTranslational Skin Cancer Research, German Cancer Consortium (DKTK), Department of Dermatology and the West German Cancer Center, Essen University Hospital, Essen, Germany.
    Purpose Of Review: Patients with stage IIIB und IV metastatic Merkel cell carcinoma (mMCC), who are not suitable candidates for surgery or radiotherapy, are unlikely to achieve lasting remission or tumor control by chemo or targeted therapy. In the majority of cases, the tumor arises from viral carcinogenesis associated with the Merkel cell polyomavirus (MCPyV). In MCPyV-negative tumors with a presumable ultraviolet carcinogenesis, a high mutational burden resulting in neoantigens was discovered. Read More

    Reduced H3K27me3 expression in Merkel cell polyoma virus-positive tumors.
    Mod Pathol 2017 Mar 10. Epub 2017 Mar 10.
    Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
    Merkel cell carcinoma is a primary cutaneous neuroendocrine carcinoma, which once metastatic is difficult to treat. Recent mutation analyses of Merkel cell carcinoma revealed a low number of mutations in Merkel cell polyomavirus-associated tumors, and a high number of mutations in virus-negative combined squamous cell and neuroendocrine carcinomas of chronically sun-damaged skin. We speculated that the paucity of mutations in virus-positive Merkel cell carcinoma may reflect a pathomechanism that depends on derangements of chromatin without alterations in the DNA sequence (epigenetic dysregulation). Read More

    Avoiding Facial Incisions with Midface Free Tissue Transfer.
    Plast Reconstr Surg Glob Open 2017 Feb 22;5(2):e1218. Epub 2017 Feb 22.
    Division of Plastic and Reconstructive Surgery, Louisiana State University Health Sciences Center School of Medicine, New Orleans, La.; Department of Plastic and Reconstructive Surgery, Johns Hopkins Medical Institute, Baltimore, Md.; Hansjörg Wyss Department of Plastic Surgery, New York University Langone Medical Center, New York, N.Y.; and Division of Plastic Surgery, University of Montreal, Montreal, QC.
    Background: We have adopted an intraoral microsurgical anastomosis to the facial vessels to eliminate the need for any visible facial incisions.

    Methods: Cadaveric dissection was used to demonstrate accessibility of the facial artery and vein through an intraoral approach. Additionally, 5 patients underwent free tissue transfer for reconstruction of major defects of the midface through an intraoral, transmucosal approach, obviating the need for visible skin incisions. Read More

    [Malignant transformation of an eccrine spiradenoma].
    Ann Dermatol Venereol 2017 Mar 27;144(3):203-207. Epub 2016 Oct 27.
    Service de pathologie, centre hospitalier Lyon sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France.
    Introduction: Malignant eccrine spiradenoma is a rare and aggressive tumor, developed on the epithelium of eccrine sweat glands. Typically, it occurs after malignant transformation of benign eccrine spiradenoma, but sometimes it happens de novo.

    Observation: We report a case of malignant eccrine spiradenoma in a 62-year-old woman. Read More

    Postoperative Radiotherapy in Salivary Gland Carcinoma: A Single Institution Experience.
    Gulf J Oncolog 2017 Jan;1(23):26-32
    Department of Otolaryngology, School of Medicine, Inonu University, Malatya, Turkey.
    Background: Salivary gland carcinoma are rare tumors and the main treatment is surgical. The addition of radiotherapy to surgery decreases locoregional relapses in high risk patients. Aim of our study is to retrospectively evaluate local control and survival and the factors affecting them in patients who received postoperative radiotherapy. Read More

    Medial canthal defects following tumour excision: To reconstruct or not to reconstruct?
    Orbit 2017 Mar 7:1-5. Epub 2017 Mar 7.
    a University Hospital of Coventry & Warwickshire , Coventry , West Midlands , United Kingdom.
    Laissez-faire following excision of peri-ocular tumours has been described, but is not universally well established. We describe our experience with laissez-faire for managing medial canthal defects following tumour excision and compare our outcomes with full thickness skin grafts. Retrospective comparative case series of 68 patients who underwent reconstruction of a medial canthal defect using laissez-faire with sutured Sorbsan (LFS) (n = 36) or a full thickness skin graft (FTSG) (n = 32) at the same centre. Read More

    Topics in histopathology of sweat gland and sebaceous neoplasms.
    J Dermatol 2017 Mar;44(3):315-326
    Division of Dermatology and Dermatopathology, Nippon Medical School Musashi Kosugi Hospital, Kawasaki City, Japan.
    This article reviews several topics regarding sweat gland and sebaceous neoplasms. First, the clinicopathological characteristics of poroid neoplasms are summarized. It was recently reported that one-fourth of poroid neoplasms are composite tumors and one-fourth are apocrine type lesions. Read More

    Long-Term Incidence of Secondary Malignancies after Allogeneic Hematopoietic Cell Transplantation: A Single-Center Experience.
    Biol Blood Marrow Transplant 2017 Feb 27. Epub 2017 Feb 27.
    Allogeneic Blood and Marrow Transplant Program, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
    To review the emergence of secondary malignancies (SMs) in recipients of allogeneic hematopoietic cell transplantation (HCT), we documented the occurrence of SMs in 2415 allogeneic HCT recipients, ages 18 to 71, in a single center over 4 decades. SMs were seen in 209 patients, including 58 with nonmetastatic squamous cell (SCC) and basal cell carcinoma (BCC) of the skin. Cumulative incidence of SM was 6. Read More

    Potential Activity of Amrubicin as a Salvage Therapy for Merkel Cell Carcinoma.
    Intern Med 2017 1;56(5):567-570. Epub 2017 Mar 1.
    Department of Hematology, Graduate School of Medicine, Chiba University, Japan.
    Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin with an aggressive clinical course. Although anthracycline- and platinum-based regimens are empirically used as first-line treatments for metastatic or unresectable cases, no salvage therapy has been established. A 73-year-old man with platinum-refractory recurrent MCC was treated with amrubicin. Read More

    Global Skin Disease Morbidity and Mortality: An Update From the Global Burden of Disease Study 2013.
    JAMA Dermatol 2017 Mar 1. Epub 2017 Mar 1.
    Institute for Health Metrics and Evaluation, University of Washington, Seattle.
    Importance: Disability secondary to skin conditions is substantial worldwide. The Global Burden of Disease Study 2013 includes estimates of global morbidity and mortality due to skin diseases.

    Objective: To measure the burden of skin diseases worldwide. Read More

    [Adverse events of immune checkpoint inhibitors].
    Urologe A 2017 Feb 28. Epub 2017 Feb 28.
    Urologische Klinik und Poliklinik, Universitätsklinikum Jena, Lessingstraße 1, 07743, Jena, Deutschland.
    After immune checkpoint inhibitor therapy was approved for renal cell carcinoma last year, this new immune therapy has spread to urology. Further approvals (atezolizumab, nivolumab, pembrolizumab) are expected in 2017 for metastatic urothelial carcinoma that has progressed following treatment with platinum-based chemotherapy. With expanding use of immune checkpoint inhibitors, experience in diagnosing and managing immune-mediated adverse events increases. Read More

    Intermittent facial spasms as the presenting sign of a recurrent pleomorphic adenoma.
    World J Clin Oncol 2017 Feb;8(1):86-90
    Rosalie A Machado, Sami P Moubayed, Mark L Urken, Thyroid, Head and Neck Cancer Foundation, New York, NY 10003, United States.
    The intimate anatomical relationship of the facial nerve to the parotid parenchyma has a significant influence on the presenting signs and symptoms, diagnosis and treatment of parotid neoplasms. However, to our knowledge, hyperactivity of this nerve, presenting as facial spasm, has never been described as the presenting sign or symptom of a parotid malignancy. We report a case of carcinoma arising in a recurrent pleomorphic adenoma of the left parotid gland (i. Read More

    Assessing and managing wounds of Buruli ulcer patients at the primary and secondary health care levels in Ghana.
    PLoS Negl Trop Dis 2017 Feb 28;11(2):e0005331. Epub 2017 Feb 28.
    Section Clinical Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.
    Background: Beyond Mycobacterium ulcerans-specific therapy, sound general wound management is required for successful management of Buruli ulcer (BU) patients which places them among the large and diverse group of patients in poor countries with a broken skin barrier.

    Methods: Clinically BU suspicious patients were enrolled between October 2013 and August 2015 at a primary health care (PHC) center and a municipal hospital, secondary health care (SHC) center in Ghana. All patients were IS2404 PCR tested and divided into IS2404 PCR positive and negative groups. Read More

    Two Different Cell Populations Is an Important Clue for Diagnosis of Primary Cutaneous Adenoid Cystic Carcinoma: Immunohistochemical Study.
    Case Rep Pathol 2017 24;2017:7949361. Epub 2017 Jan 24.
    Pathology Department, Abdurrahman Yurtaslan Oncology Education and Research Hospital, Ankara, Turkey.
    Primary cutaneous adenoid cystic carcinoma (PCACC) is a very rare malignancy. The differential diagnosis of PCACCs in pathology practice can be difficult and a group of primary and metastatic lesions, including adenoid basal cell carcinoma of the skin, should be considered in the differential diagnosis. Besides histomorphological clues, immunohistochemistry studies are very helpful in the differential diagnosis of PCACC. Read More

    Secondary Cutaneous Amyloidosis in a Patient with Mycosis Fungoides.
    Ann Dermatol 2017 Feb 3;29(1):79-82. Epub 2017 Feb 3.
    Department of Dermatology, Dankook University Medical College, Cheonan, Korea.
    Secondary cutaneous amyloidosis refers to clinically unapparent amyloid deposits within the skin in association with a pre-existing skin condition or skin tumors, such as basal cell carcinoma, porokeratosis, solar elastosis, Bowen's disease, and mycosis fungoides. A 70-year-old woman presented with a 6-month history of asymptomatic multiple yellowish plaques on both legs. She had been diagnosed with mycosis fungoides 7 years ago and was treated with psoralen and ultraviolet A radiation (PUVA) therapy, narrow-band ultraviolet B (UVB) therapy, and acitretin for 5 years. Read More

    A Rare Case of CK20/CK7 Double Negative Merkel Cell Carcinoma.
    Am J Dermatopathol 2017 Mar;39(3):208-211
    *Department of Pathology, University of California Los Angeles, Los Angeles, CA; †Southern California Permanente Medical Group, Department of Dermatology, Sunset Medical Center, Los Angeles, CA; and ‡Department of Pathology, Kaiser Southern California Permanente Medical Group, Los Angeles, CA.
    The authors present a case of Merkel cell carcinoma (MCC) with unique immunohistochemical staining characteristics. A 57-year-old woman presented with a firm 0.3 cm tan papule on her left nasal-labial fold that was reportedly increasing in size and bleeding. Read More

    Multiple nonsyndromic acquired basal cell carcinomas : Uncommon clinical presentation in a Bulgarian patient.
    Wien Med Wochenschr 2017 Feb 20. Epub 2017 Feb 20.
    Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany.
    Basal cell carcinoma is the most frequent cutaneous neoplasm, with slowly progressive nature and locally invasive behavior. Despite the low metastatic potential, local tissue destruction and disfigurement caused by the tumor can be large if not eradicated in time by early diagnosis and treatment. Both genetic predisposition and exposure to environmental risks are involved in the pathogenesis of the malignant transformation in BCC. Read More

    Cytology of the neovagina in transgender women and individuals with congenital or acquired absence of a natural vagina.
    Cytopathology 2017 Feb 20. Epub 2017 Feb 20.
    Institute of Clinical Pathology, University Hospital Zurich, Zurich, Switzerland.
    Objective: The primary objective of this study was to describe the cytological findings of bowel and (penile) skin-lined neovaginas in patients with gender dysphoria (GD) and individuals with a congenital or acquired absence of a natural vagina. The secondary objective was to correlate the cytological findings with clinical characteristics such as oestrogen replacement therapy (ERT).

    Methods: A retrospective review of an institutional pathology archive over a 15-year-period was performed to identify cytological samples of neovaginal vaults. Read More

    Inguinal lymph node presenting as the delayed site of metastasis in early stage endometrial carcinoma: Case report.
    Int J Surg Case Rep 2017 19;32:12-15. Epub 2017 Jan 19.
    Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, 59046, Saudi Arabia. Electronic address:
    Introduction: Inguinal lymph nodes are the frequent sites of metastasis for malignant lymphoma, squamous cell carcinoma of anal canal, vulva and penis, malignant melanoma and squamous cell carcinoma of skin over lower extremities or trunk. Anatomically, endometrial carcinoma is less likely to spread to the superficial or deep inguinal lymph nodes, thus metastatic involvement of these lymph nodes can easily be overlooked.

    Case Presentation: Here-in we report a case of a 65-year old Saudi morbid obese female, who presented with left inguinal lymphadenopathy as initial delayed site of metastasis almost 19 months after the initial treatment for FIGO IA endometrial carcinoma. Read More

    Undermining plastic surgery as a possible option for treating basal cell carcinoma of the forehead.
    Wien Med Wochenschr 2017 Feb 13. Epub 2017 Feb 13.
    Department of Pathology, University of Virginia Health System, 1215 Lee Street, 800214, 22908, Charlottesville, VA, USA.
    Basal cell carcinoma (BCC) is the most common cutaneous cancer. Although most cases can be cured with simple surgical procedures and are associated with a good prognosis, a minority of BCCs may pose significant therapeutic challenges. This occurs mostly in cases of so-called advanced BCC, which a loosely defined term that encompasses locally advanced lesions and tumors with metastatic spread. Read More

    Capecitabine-Associated Loss of Fingerprints: Report of Capecitabine-Induced Adermatoglyphia in Two Women with Breast Cancer and Review of Acquired Dermatoglyphic Absence in Oncology Patients Treated with Capecitabine.
    Cureus 2017 Jan 9;9(1):e969. Epub 2017 Jan 9.
    Department of Dermatology, University of California, San Diego.
    Capecitabine, an oral 5-fluorouracil prodrug, is currently used in the treatment of metastatic colorectal carcinoma and breast cancer. Fingerprints, also referred to as dermatoglyphics and characterized by the pattern of ridges and furrows on the fingertips, are used for identification by government agencies and personal electronic devices. Two women with breast cancer who were treated with capecitabine and developed drug-associated loss of their fingerprints are described. Read More

    Renal Cell Carcinoma Metastatic to the Scalp.
    Rare Tumors 2016 Nov 20;8(4):6400. Epub 2016 Dec 20.
    The University of Texas Southwestern Medical School, Dallas; Veterans' Affairs Hospital, Dallas, TX, USA.
    Because of the asymptomatic natural history of renal cell carcinoma (RCC), by the time a diagnosis is made, metastatic disease is present in about one third of the cases. Thus, the overall survival of patients with RCC remains poor. Ultimately up to 50% of patients with RCC will develop metastases. Read More

    Unusual sites of metastases of carcinoma cervix.
    BMJ Case Rep 2017 Feb 7;2017. Epub 2017 Feb 7.
    Department of Radiotherapy, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
    We present a case of metastatic squamous cell carcinoma cervix with solitary bone metastases to the right tibia and multiple cutaneous metastases. A woman aged 52 years with cancer of the cervix and lung metastases, after 21 months of initial diagnosis and palliative chemotherapy presented with pain in the right knee and multiple nodular skin lesions. Bone scintigraphy revealed intense increased tracer activity in the proximal and mid shaft of the right tibia. Read More

    Utility of prospective pathologic evaluation to inform clinical genetic testing for hereditary leiomyomatosis and renal cell carcinoma.
    Cancer 2017 Feb 7. Epub 2017 Feb 7.
    Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
    Background: Patients with hereditary leiomyomatosis and renal cell carcinoma (HLRCC) resulting from fumarate hydratase (FH) mutations may present with skin, uterine, and renal tumors, with each having unique pathologic features. This study investigated the association between prospectively identified suspicious pathology (SP) and FH mutations when patients were referred for genetic testing.

    Methods: This was an institutional review board-approved cohort study of patients receiving FH testing from 2008 to 2013. Read More

    Low-Grade Neuroendocrine Carcinoma of the Skin (Primary Cutaneous Carcinoid Tumor) as a Distinctive Entity of Cutaneous Neuroendocrine Tumors: A Clinicopathologic Study of 3 Cases With Literature Review.
    Am J Dermatopathol 2017 Apr;39(4):250-258
    *Department of Diagnostic Pathology, Kainan Hospital, Yatomi, Japan; †Sapporo Dermatopathology Institute, Sapporo, Japan; ‡Department of Plastic and Reconstructive Surgery, Saitama Medical University, Saitama, Japan; §Departments of Dermatology, and ¶Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan; and ‖Department of Breast Surgery, Kainan Hospital, Yatomi, Japan.
    There is scarcity of information on primary cutaneous low-grade neoplasms commonly known as carcinoid tumors, owing to their rarity. The authors present 3 cases that were named "low-grade neuroendocrine carcinoma of the skin" (LGNECS). These occurred in the dermis and subcutis of the anterior chest or the inguinal region in the elderly. Read More

    Drug therapy of advanced cutaneous squamous cell carcinoma: is there any evidence?
    Curr Opin Oncol 2017 Mar;29(2):129-135
    aDepartment of Medical Sciences, Section of Dermatology, University of Turin, Turin bDepartment of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy cMoores Cancer Center, University of California, San Diego, San Diego, California, USA dDepartment of Dermatology, University of Bern, Inselspital, Berne, Switzerland.
    Purpose Of Review: There are few randomized controlled studies to guide the treatment of advanced cutaneous squamous cell carcinoma. The existing treatments are mostly based on case reports and small case series. Here we review recently available insights concerning the treatment of locally advanced and metastatic squamous cell carcinoma, with a special emphasis on novel targeted therapy and immunotherapy. Read More

    Stromal microenvironment in type VII collagen-deficient skin: The ground for squamous cell carcinoma development.
    Matrix Biol 2017 Jan 24. Epub 2017 Jan 24.
    Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Via dei Monti di Creta 104, 00167 Rome, Italy. Electronic address:
    Recessive dystrophic epidermolysis bullosa (RDEB) is a skin fragility disease caused by mutations that affect the function and/or the amount of type VII collagen (C7), the major component of anchoring fibrils. Hallmarks of RDEB are unremitting blistering and chronic wounds leading to tissue fibrosis and scarring. Nearly all patients with severe RDEB develop highly metastatic squamous cell carcinomas (SCC) which are the main cause of death. Read More

    Silibinin Treatment Inhibits the Growth of Hedgehog Inhibitor-Resistant Basal Cell Carcinoma Cells via Targeting EGFR-MAPK-Akt and Hedgehog Signaling.
    Photochem Photobiol 2017 Jan 25. Epub 2017 Jan 25.
    Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO.
    Basal cell carcinoma (BCC) is the most common skin malignancy. Deregulated hedgehog signaling plays a central role in BCC development; therefore, hedgehog inhibitors have been approved to treat locally advanced or metastatic BCC. However, the development of resistance to hedgehog inhibitors is the major challenge in effective treatment of this disease. Read More

    Intraepidermal proliferation of Merkel cells within a seborrheic keratosis: Merkel cell carcinoma in situ or Merkel cell hyperplasia?
    J Cutan Pathol 2017 Jan 20. Epub 2017 Jan 20.
    Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania.
    Intradepidermal proliferation of Merkel cells without any dermal component has been interpreted as either a hyperplastic process secondary to chronic ultraviolet radiation or a neoplastic process, namely Merkel cell carcinoma (MCC) in situ. The recent criteria that have been proffered to diagnose MCC in situ, unfortunately, are identical to those that have been applied to Merkel cell hyperplasia in the past, posing a diagnostic quandary when faced with an intraepidermal proliferation of Merkel cells. Most previously reported cases of MCC in situ have occurred within associated epithelial lesion that includes solar (actinic) keratosis and squamous-cell carcinoma in situ. Read More

    Cancer-associated fibroblasts enact field cancerization by promoting extratumoral oxidative stress.
    Cell Death Dis 2017 Jan 19;8(1):e2562. Epub 2017 Jan 19.
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore.
    Histological inspection of visually normal tissue adjacent to neoplastic lesions often reveals multiple foci of cellular abnormalities. This suggests the presence of a regional carcinogenic signal that spreads oncogenic transformation and field cancerization. We observed an abundance of mutagenic reactive oxygen species in the stroma of cryosectioned patient tumor biopsies, indicative of extratumoral oxidative stress. Read More

    Risk of Aggressive Skin Cancers After Kidney Retransplantation in Patients With Previous Posttransplant Cutaneous Squamous Cell Carcinomas: A Retrospective Study of 53 Cases.
    Transplantation 2017 Apr;101(4):e133-e141
    1 Department of Dermatology, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France. 2 Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands. 3 Hospices Civils de Lyon, Pôle Information Médicale Evaluation Recherche, Unité de Recherche Clinique, Lyon, France. 4 Université de Lyon, Laboratoire Santé Individu Société, Lyon, France. 5 Department of Dermatology, Nantes University Medical Center, Nantes, France. 6 Department of Dermatology, Saint Louis Hospital, APHP, University Paris VII, Paris, France. 7 Department of Dermatology, Tenon Hospital, APHP, University Paris VI, Paris, France. 8 Department of Transplantation and Nephrology, Edouard Herriot Hospital, Université de Lyon, Lyon, France. 9 Department of Nephrology-Transplantation, Necker Hospital, APHP, Paris, France. 10 Department of Dermatology, Charles-Nicolle University Medical Center, Rouen, France. 11 Department of Renal Medicine and Transplantation, Nantes University Medical Center, Nantes, France.
    Background: The course of skin cancer after retransplantation in organ-transplant recipients who have already developed posttransplant skin cancer has not been assessed.

    Methods: This retrospective multicentric study included 53 patients with a history of cutaneous squamous cell carcinoma (SCC) after a first kidney transplantation who received a second kidney transplantation. The primary endpoint was the occurrence of aggressive cutaneous SCC after the second transplantation. Read More

    Successful surgical treatment for squamous cell carcinoma arising from hidradenitis suppurativa: A case report and literature review.
    Medicine (Baltimore) 2017 Jan;96(3):e5857
    aDivision of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital, Beijing, P.R. China bDepartment of Medicine, the University of Melbourne, Parkville, Victoria, Australia cDepartment of Pathology, Peking Union Medical College Hospital, Beijing, P.R. China.
    Rationale: Hidradenitis suppurativa (HS) is a disabling inflammatory disease mainly affecting apocrine glands. Marjolin ulcer (MU) is a term used to describe a rare type of squamous cell carcinoma (SCC) arising within sites of chronic wounds or preexisting scars. Chronic HS may result in a rare type of SCC, MU, which has a poor prognosis due to its high metastatic rate. Read More

    Late side-effects and cosmetic results of accelerated partial breast irradiation with interstitial brachytherapy versus whole-breast irradiation after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: 5-year results of a randomised, controlled, phase 3 trial.
    Lancet Oncol 2017 Feb 14;18(2):259-268. Epub 2017 Jan 14.
    Department of Radiation Oncology, University Hospital Erlangen, Erlangen, Germany.
    Background: We previously confirmed the non-inferiority of accelerated partial breast irradiation (APBI) with interstitial brachytherapy in terms of local control and overall survival compared with whole-breast irradiation for patients with early-stage breast cancer who underwent breast-conserving surgery in a phase 3 randomised trial. Here, we present the 5-year late side-effects and cosmetic results of the trial.

    Methods: We did this randomised, controlled, phase 3 trial at 16 centres in seven European countries. Read More

    Successful recovery from a subclavicular ulcer caused by lenvatinib for thyroid cancer: a case report.
    World J Surg Oncol 2017 Jan 14;15(1):24. Epub 2017 Jan 14.
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, 606-8507, Japan.
    Background: There are currently no effective therapeutic methods for locally recurrent, metastatic, or progressive radioactive iodine (RAI)-refractory differentiated thyroid cancer. However, multitargeted tyrosine kinase inhibitors (TKIs) such as lenvatinib or sorafenib have been approved for patients with RAI-refractory differentiated thyroid cancer as a second targeted therapy, and these agents can prolong patient survival. However, several cases have been reported that TKIs have caused fatal complications such as fistula formation or bleeding. Read More

    Giant Anterior Chest Wall Basal Cell Carcinoma: An Approach to Palliative Reconstruction.
    Case Rep Oncol Med 2016 19;2016:5067817. Epub 2016 Dec 19.
    Department of Plastic Surgery, University of California, Irvine, CA, USA.
    Anterior chest wall giant basal cell carcinoma (GBCC) is a rare skin malignancy that requires a multidisciplinary treatment approach. This case report demonstrates the challenges of anterior chest wall GBCC reconstruction for the purpose of palliative therapy in a 72-year-old female. Surgical resection of the lesion included the manubrium and upper four ribs. Read More

    Patterns of Care and Clinical Outcomes in Patients With Metastatic Renal Cell Carcinoma-Results From a Tertiary Cancer Center in India.
    Clin Genitourin Cancer 2016 Oct 19. Epub 2016 Oct 19.
    Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India. Electronic address:
    Introduction: The current treatment of metastatic renal cell carcinoma (mRCC) revolves around targeted agents, which have resulted in a median overall survival of 22 to 26 months in registration trials. However, the outcomes in a non-trial, real-world Indian population have not yet been evaluated.

    Materials And Methods: The present study was a part of a prospective Clinical Trials Registry-India-registered study, the Kidney Cancer Registry, a prospectively maintained kidney cancer registry. Read More

    Anti-metastatic effect of rhodomyrtone from Rhodomyrtus tomentosa on human skin cancer cells.
    Int J Oncol 2017 Mar 9;50(3):1035-1043. Epub 2017 Jan 9.
    Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand.
    This study focused on the inhibitory effect of rhodomyrtone, a bioactive compound isolated from the leaves of Rhodomyrtus tomentosa (Aiton) Hassk., on cancer metastasis in epidermoid carcinoma A431 cells and on the verification of the underlying related molecular mechanisms of this event. We demonstrated that rhodomyrtone at the subcytotoxic concentration (0. Read More

    Pneumonitis in cancer patients receiving anti-PD-1 and radiotherapies: Three case reports.
    Medicine (Baltimore) 2017 Jan;96(1):e5747
    aDepartment of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung bDivision of Hematology/Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei cDivision of Hematology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
    Introduction: In development of novel therapies for the treatment of patient with cancer, the use of radiotherapy (RT) can produce significant local control and, in recent studies, has also been shown to mediate anti-tumor responses at distant sites by triggering and enhancing the endogenous cellular immune responses. Although RT induces an abscopal effect in some patients due to enhanced immune response to the tumor, immune-escape mechanisms, including up-regulation of programmed death-ligand 1 (PD-L1) on tumor cells, limit this benefit in other patients. Hence, many studies have promoted the synergy of RT and anti-programmed cell death protein 1 (PD-1) treatment for antitumor immunity. Read More

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