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    8492 results match your criteria Metastatic Carcinoma of the Skin

    1 OF 170

    Standardization of simple auxiliary method beneficial to total endoscopic thyroidectomy on patients with PTC, based on retrospective study of 356 cases.
    Endocrine 2018 Apr 24. Epub 2018 Apr 24.
    Department of Thyroid and Vascular Surgery, Fujian Medical University Union Hospital, 350000, Fuzhou, Fujian, China.
    Objective: Total endoscopic thyroidectomy (TET) is paid increasing attention to by patients, especially those with thyroid carcinoma. The aim of this study is to evaluate the clinic feasibility of standardization of simple auxiliary method (SOSAM) involved in operating bed adjustment, location of skin traction points and thyroid retractor points for the TET via bilateral breast approach.

    Methods: A retrospective study was performed on 356 patients with thyroid carcinoma, who had undergone the TET. Read More

    Isolation of Normal Fibroblasts and Their Cancer-Associated Counterparts (CAFs) for Biomedical Research.
    Methods Mol Biol 2018 Apr 20. Epub 2018 Apr 20.
    First Faculty of Medicine, Institute of Anatomy and BIOCEV, Charles University, Prague, Czech Republic.
    Cancer-associated fibroblasts (CAFs) represent a crucial component of cancer microenvironment. CAFs significantly influence biological properties of various types of cancer in terms of local aggressiveness, recurrence, and metastatic behaviour. This chapter summarizes a simple protocol for isolation of normal fibroblasts and their cancer-associated counterparts from normal human skin and mucosa, respectively, as well as from samples of human tumours such as basal/squamous carcinoma, melanoma, and breast cancer, and employment of this procedure for other types of cancer is possible. Read More

    Breast cancer cutaneous metastases mimicking Papilloma Cutis Lymphostatica. Biopsy to avoid pitfalls.
    Int J Surg Case Rep 2018 Apr 10;46:31-33. Epub 2018 Apr 10.
    Department of Plastic and Reconstructive Surgery, University of Bari, Italy.
    Introduction: Secondary lymphedema is the most frequent long-term complication of axillary lymphadenectomy. It can result in complication as erysipelas, warts, Papilloma Cutis Lymphostatica (PCL), or angiosarcomas. Moreover, in women affected by breast cancer an accurate differential diagnosis among these conditions or complication related to radiation dermatitis or cutaneous metastasis is essential. Read More

    Advanced cutaneous squamous cell carcinoma: A retrospective analysis of patient profiles and treatment patterns-Results of a non-interventional study of the DeCOG.
    Eur J Cancer 2018 Apr 14;96:34-43. Epub 2018 Apr 14.
    Department of Dermatology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
    Background: Advanced cutaneous squamous cell carcinoma (aSCC) is an area of unmet medical need and no treatment standards are established. Recently, an anti-PD-1 inhibitor received FDA breakthrough therapy designation. The aim of the study was to describe the clinical course, therapeutic management and prognosis of aSCC under real-life conditions. Read More

    Endoscopic ultrasound diagnosis of Merkel cell carcinoma metastasizing to pancreas.
    Cytopathology 2018 Apr 17. Epub 2018 Apr 17.
    Gastroenterology Department, Instituto Português de Oncologia do Porto, Porto, Portugal.
    Merkel cell carcinoma (MCC) is a rare and aggressive primary neuroendocrine tumor of the skin, with a high propensity for local, regional and distant spread . However, distant metastasis of MCC to the pancreas are rarely seen. EUS-FNA is an effective tool in the evaluation and differential diagnosis of pancreatic mass lesions . Read More

    Cutaneous Head and Neck Malignancies in the Elderly.
    Clin Geriatr Med 2018 May 17;34(2):245-258. Epub 2018 Feb 17.
    Otolaryngology-Head and Neck Surgery, Head and Neck-Microvascular Surgery, Clinical Affairs, Indiana University School of Medicine, Fesler Hall, 1130 W. Michigan Street, Suite 400, Indianapolis, IN 46202, USA.
    Cutaneous malignancy of the head and neck affects a large proportion of elderly patients. The severity ranges from small, easily treatable lesions to large, invasive, potentially metastatic tumors. Surgical treatment is the primary treatment of most skin cancers; however, geriatric patients are more likely to have multiple comorbidities that increase the risk of surgery. Read More

    Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal.
    Cell 2018 Apr 12;173(3):581-594.e12. Epub 2018 Apr 12.
    Translational Cancer Therapeutics Laboratory, the Francis Crick Institute, London NW1 1AT, UK; Cancer Research UK Lung Cancer Centre of Excellence London, University College London Cancer Institute, London WC1E 6DD, UK; Department of Medical Oncology, University College London Hospitals, London NW1 2BU, UK. Electronic address:
    Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with metastatic ccRCC, including two cases sampledat post-mortem. Metastatic competence was afforded by chromosome complexity, and we identify 9p loss as a highly selected event driving metastasis and ccRCC-related mortality (p = 0. Read More

    Perforating osteoma cutis: case report and literature review of patients with a solitary perforating osteoma cutis lesion.
    Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
    Department of Dermatology, University of California San Diego, La Jolla, California, USA.
    Osteoma cutis, the development of bone in the dermis and/or subcutaneous fat, can occur as either a primary or secondary condition. Perforating osteoma cutis is rare. A man with a solitary lesion of perforating osteoma cutis is described and the features of individuals with a single perforating osteoma cutis skin lesion are reviewed. Read More

    Merkel cell carcinoma in the community setting: a case report.
    Radiat Oncol J 2018 Apr 12. Epub 2018 Apr 12.
    Department of Radiation Oncology, Osceola Cancer Center, Kissimmee, FL, USA.
    Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin initially believed to arise from the Merkel cells. In the community setting a general radiation oncologist may only encounter this pathology in a handful of cases over the course of their career. Due to the low incidence of this malignancy, few prospective randomized controlled trials have ever been conducted and therefore guidelines are based on relatively lower levels of evidence upon which the clinical recommendations are made. Read More

    A Scoping Review Protocol to Explore the Use of Interleukin-1-Targeting Drugs for the Treatment of Dermatological Diseases: Indications, Mechanism of Action, Efficacy, and Safety.
    Dermatol Ther (Heidelb) 2018 Apr 6. Epub 2018 Apr 6.
    Department of Dermatology, Hospital Universitario Reina Sofía, Córdoba, Spain.
    Introduction: The interleukin (IL)-1 pathway has been identified as being involved in inflammatory and neoplastic skin diseases such as psoriasis, atopic dermatitis, neutrophilic dermatosis, melanoma, and squamous cell carcinoma. Drugs developed to target the IL-1 pathway are currently used to treat these pathologies, and although they are becoming more selective, they are not exempt from adverse events and high costs. Integrating the best research evidence with clinical experience and patient needs has been shown to improve care, health, and cost outcomes. Read More

    Primary basosquamous carcinoma of the lower eyelid with ocular invasion A case report.
    Ann Ital Chir 2018 Mar 26;7. Epub 2018 Mar 26.
    Introduction: Ocular invasion is extremely rare for a primary eyelid Basosquamous Carcinoma (BSC). It can however occur in neglected cases if the clinical signs are overseen and the BSC is misdiagnosed for a less aggressive skin carcinoma.

    Materials And Methods: A 58-year-old man suffering from an inferior eyelid BSC that had been neglected for 7 years was referred to our clinic. Read More

    [Microcystic adnexal carcinoma: A case report].
    Ann Pathol 2018 Apr 2. Epub 2018 Apr 2.
    Service de dermatologie, CHU de Caen, avenue côte-de-nacre, 14033 Caen, France.
    We report a case of microcystic adnexal carcinoma in a 80-year-old woman. This is a rare malignant adnexal cutaneous tumor with glandular and follicular differentiation, rare, often asymptomatic, with late diagnosis and slow growth, locally aggressive and rarely metastatic. The distinction with other benign and malignant skin tumors is difficult. Read More

    Primary mucinous carcinoma of skin with a trichoadenomatous component: A rare case report.
    Indian J Dermatol Venereol Leprol 2018 Apr 4. Epub 2018 Apr 4.
    Leelavathi Advanced Skin and Laser Centre, Guntur, Andhra Pradesh, India.
    Primary mucinous carcinoma of the skin is a rare subtype of eccrine sweat gland tumors. Differentiating it from metastatic adenocarcinomas is important in the management of this condition. We report the case of a 55-year-old female presenting with a painless nodule, which was subsequently diagnosed as primary mucinous carcinoma of skin with a trichoadenomatous component. Read More

    Assessment of Sunitinib Alternative Prescription Schedules in Metastatic Kidney Cancer: A Study of 10 Cases.
    Gulf J Oncolog 2018 Jan;1(26):33-36
    Oncology Center of Marrakech, Morocco.
    Background: Managing metastatic Renal Cell Carcinoma (mRCC) has been revolutionized during the first decade of the 21st century due to the development of targeted therapies. The sunitinib is an oral multi-targeted receptor Tyrosine Kinase Inhibitor (TKI). It became the first targeted therapy as first-line treatment to improve the survival of patients with metastatic kidney cancer. Read More

    [Malignant transformation of chronic osteomyelitis: a case report].
    Pan Afr Med J 2017 31;28:188. Epub 2017 Oct 31.
    Laboratoire d'Anatomie et de Cytologie Pathologiques, Hôpital Habib Bourguiba - Médenine, Médenine, Tunisie.
    Malignant transformation of chronic osteomyelitis is a rare and late complication which mainly occurs at the level of the edges of a fistulous tract with extension and infiltration to the surrounding soft tissues and more rarely to bones. We here report the case of Mr N.J. Read More

    Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma.
    Oncotarget 2018 Mar 22;9(18):14552-14566. Epub 2018 Feb 22.
    Division of Cancer Research, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK.
    The incidence of cutaneous squamous cell carcinoma (cSCC) is rising. Whilst the majority are cured surgically, aggressive metastatic cSCC carry a poor prognosis. Inactivating mutations in transforming growth factor beta (TGF-β) receptors have been identified amongst genetic drivers of sporadic tumours and murine models of cSCC, suggesting a tumour suppressor function for TGF-β in normal skin. Read More

    Erlotinib in the treatment of recurrent or metastatic cutaneous squamous cell carcinoma: A single-arm phase 2 clinical trial.
    Cancer 2018 Mar 26. Epub 2018 Mar 26.
    Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Background: Cutaneous squamous cell carcinoma (CSCC) is a very common malignancy in which most patients present with localized disease. Recurrent and metastatic disease is rare, and there is no standard therapy. These tumors frequently overexpress the epidermal growth factor receptor (EGFR). Read More

    Georgian Med News 2018 Feb(Issue):77-80
    Clinica Goldman, Porto Alegre, Rio Grande do Sul, Brazil; Department of Dermatology and Allergology, Municipal Hospital Dresden, Academic Teaching Hospital of the Technical University of Dresden, Germany.
    Keratoakanthoma (KA) is a common non-melanoma skin tumor of sun-exposed skin. Recently it has been classified as a highly differentiated squamous cell carcinoma, based on the evidence of local destruction, tissue invasion and malignant transformation with metastatic spread described in the medical literature. Lower lip KA is not uncommon on lower lip, and quite rare on upper lip. Read More

    Merkel cell carcinoma with seborrheic keratosis: A unique association.
    Indian J Pathol Microbiol 2018 Jan-Mar;61(1):101-102
    Department of Pathology, SRL Reference Lab, Bengaluru, Karnataka, India.
    Merkel cell carcinoma (MCC) is a rare, clinically aggressive neuroendocrine carcinoma of the skin; MCC is 40 times less common as compared to melanoma. The most frequently reported sites have been the head and neck, extremities, and trunk. Potential mimics include malignant melanoma, lymphoma, or metastatic small cell (neuroendocrine) carcinomas. Read More

    Efficacy and Safety of First-line Avelumab Treatment in Patients With Stage IV Metastatic Merkel Cell Carcinoma: A Preplanned Interim Analysis of a Clinical Trial.
    JAMA Oncol 2018 Mar 22. Epub 2018 Mar 22.
    Rutgers Cancer Institute of New Jersey, New Brunswick.
    Importance: Merkel cell carcinoma (MCC) is an aggressive skin cancer that is associated with poor survival outcomes in patients with distant metastatic disease. Results of part A of the JAVELIN Merkel 200 trial (avelumab in patients with Merkel cell carcinoma) showed that avelumab, an anti-programmed cell death ligand 1 (PD-L1) antibody, demonstrated efficacy in second-line or later treatment of patients with metastatic MCC (mMCC).

    Objective: To evaluate the efficacy and safety of avelumab as first-line treatment for patients with distant mMCC. Read More

    Proceedings of the NASHNP Companion Meeting, March 18th, 2018, Vancouver, BC, Canada: Salivary Neuroendocrine Carcinoma-An Overview of a Rare Disease with an Emphasis on Determining Tumor Origin.
    Head Neck Pathol 2018 Mar 20;12(1):13-21. Epub 2018 Mar 20.
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8118, St. Louis, MO, USA.
    Salivary neuroendocrine carcinomas are rare and the overwhelming majority is high-grade. The parotid gland is the most commonly involved site followed by the submandibular gland. Most arise de novo but rare examples occurring as a high-grade transformation of another type of salivary gland neoplasm exist. Read More

    Acantholytic squamous cell carcinoma of the lung with marked lymphogenous metastases and high titers of myeloperoxidase-antineutrophil cytoplasmic antibodies: a case report.
    BMC Cancer 2018 03 16;18(1):300. Epub 2018 Mar 16.
    Department of Radiology, Japanese Red Cross Kochi Hospital, 2-13-51, Shinhonmachi, Kochi-city, Kochi, 780-8562, Japan.
    Background: Acantholytic squamous cell carcinoma (ASQCC), histologically characterized by intercellular bridge loosening, is recognized as a rare variant of squamous cell carcinoma (SQCC). ASQCC may demonstrate a worse prognosis than conventional SQCC. Pulmonary ASQCC is particularly rare; its biological behavior and prognostic data have not been reported. Read More

    [Chronic ulceration of the hand in a mechanic: epidermoid carcinoma should be suspected].
    Pan Afr Med J 2017 14;28:141. Epub 2017 Oct 14.
    Service de Dermatologie et Vénérologie, Centre Hospitalier Universitaire IBN Sina, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.
    Cutaneous squamous cell carcinoma is a malignant tumor developed from the epidermis or the squamous mucosa. It may occur de novo or, most often, on precancerous lesions, including actinic keratoses. This tumor can sometimes be secondary to physical or chemical hazardous conditions encountered during the professional activity. Read More

    Immunotherapy in Merkel cell carcinoma: role of Avelumab.
    Immunotargets Ther 2018 2;7:15-19. Epub 2018 Mar 2.
    Department of Internal Medicine, Division of Hematology and Oncology, Ellis Fischel Cancer Center, University of Missouri, Columbia, MO, USA.
    Merkel cell carcinoma (MCC), a rare skin cancer, is associated with high mortality, especially in a metastatic setting. Though conventional chemotherapy with platinum and etoposide has had high response rates, many of the patients have had early relapse without any effective therapy thereafter. Recently, immune check point inhibitors have shown very good durable responses, leading to the approval of a programmed death-ligand 1 inhibitor Avelumab for these patients. Read More

    The Expression and Prognostic Impact of Immune Cytolytic Activity-Related Markers in Human Malignancies: A Comprehensive Meta-analysis.
    Front Oncol 2018 21;8:27. Epub 2018 Feb 21.
    Department of Life Sciences, Biomedical Sciences Program, School of Sciences, European University Cyprus, Nicosia, Cyprus.
    Background: Recently, immune-checkpoint blockade has shown striking clinical results in different cancer patients. However, a significant inter-individual and inter-tumor variability exists among different cancers. The expression of the toxins granzyme A (GZMA) and perforin 1 (PRF1), secreted by effector cytotoxic T cells and natural killer (NK) cells, were recently used as a denominator of the intratumoral immune cytolytic activity (CYT). Read More

    Living with Merkel Cell Carcinoma (MCC): Development of a Conceptual Model of MCC Based on Patient Experiences.
    Patient 2018 Mar 6. Epub 2018 Mar 6.
    Merck KGaA, Darmstadt, Germany.
    Background: Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with limited treatment options at advanced stages. There is a paucity of data available regarding the impact of MCC and its management on patients' lives. This study aimed to address this gap by interviewing patients with metastatic MCC entering a trial of an immunotherapy (avelumab). Read More

    Merkel cell carcinoma masquerading as cellulitis: a case report and review of the literature.
    Curr Oncol 2018 Feb 28;25(1):e106-e112. Epub 2018 Feb 28.
    Department of Hematology and Oncology, Staten Island University Hospital, Staten Island, NY, USA; and.
    Merkel cell carcinoma (mcc) is an uncommon malignancy of the skin arising from cells located in the deeper layers of the epidermis called Merkel cells. This malignancy rarely presents as a metastatic disease, and the field is therefore deficient in regards to management. We report the case of a 49-year-old woman who presented with a presumptive diagnosis of osteomyelitis of the left fifth digit that was resistant to treatment with antibiotics; she underwent debridement of the digit that revealed mcc and was later to have metastatic disease to her lungs, liver, and musculoskeletal system. Read More

    A case report of squamous cell carcinoma in a suprapubic urinary catheter tract: surgical excision and simultaneous colostomy formation.
    J Surg Case Rep 2018 Feb 23;2018(2):rjy030. Epub 2018 Feb 23.
    Department of Urology, Royal Devon & Exeter Hospital, Exeter EX2 5DW, UK.
    Squamous cell carcinoma (SCC) arising from a suprapubic cystostomy tract is a rare complication of long-term suprapubic catheterization (SPC). A 53-year-old man with paraplegia secondary to spina bifida presented with a painful granulomatous lesion around his SPC site that was being treated with silver nitrate cauterization in the community. Consequently, he developed a sacral pressure sore due to reduced mobility from the pain. Read More

    Giant Pendulous Carcinosarcoma - Squamous Cell Carcinoma-Type - of the Leg - A Case Report and Review of the Literature.
    Open Access Maced J Med Sci 2018 Jan 10;6(1):112-114. Epub 2018 Jan 10.
    Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior, Sofia, Bulgaria.
    Cutaneous carcinosarcoma (CCS) is a rare non-melanoma skin cancer with a biphasic growth pattern. A tumour is composed of epithelial and mesenchymal cells that show clonality. In most cases, CCS develops in the head-and-neck region on the chronic sun-exposed skin of males. Read More

    Phase I Study of LY2940680, a Smo Antagonist, in Patients with Advanced Cancer Including Treatment-Naïve and Previously Treated Basal Cell Carcinoma.
    Clin Cancer Res 2018 Feb 26. Epub 2018 Feb 26.
    Translational Genomics Research Institute, Phoenix, Arizona.
    The purpose of this study was to determine a recommended phase II dose and schedule of LY2940680 (taladegib) for safe administration to patients with locally advanced/metastatic cancer. This was a phase I, multicenter, open-label study of oral LY2940680. The maximum tolerable dose (MTD) was determined using a 3+3 design, the dose was confirmed, and then treatment-naïve and previously hedgehog (Hh)-inhibitor-treated patients with basal cell carcinoma (BCC) were enrolled. Read More

    Avelumab: a new standard for treating metastatic Merkel cell carcinoma.
    Expert Rev Anticancer Ther 2018 Apr 28;18(4):319-326. Epub 2018 Feb 28.
    a Dermatology Branch , National Institute of Arthritis and Musculoskeletal and Skin Disorders , Bethesda , MD , USA.
    Introduction: Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer. Although MCC is chemosensitive, responses to traditional chemotherapeutic agents are not durable. Avelumab, a novel anti-PD-L1 immune checkpoint inhibitor, recently became the first FDA-approved agent for the treatment of metastatic MCC and represents a new option to improve patient survival. Read More

    Subcutaneous metastasis of a pulmonary carcinoid tumor: A case report.
    Medicine (Baltimore) 2018 Jan;97(2):e9415
    Department of Pulmonology.
    Rationale: Carcinoid tumors are derived from neuroendocrine cells and are most frequently found in the gastrointestinal tract and bronchopulmonary system. They are generally characterized by an indolent clinical course but may in some instances spread to regional lymph nodes or to distant sites. Subcutaneous metastases of carcinoid tumors are extremely rare; there are only few cases reported in the literature and the site of the primary tumor was mainly the gastrointestinal tract. Read More

    PD-L1 inhibition with avelumab for metastatic Merkel cell carcinoma.
    Expert Rev Clin Pharmacol 2018 Apr 14;11(4):345-359. Epub 2018 Mar 14.
    d Dermatology Branch , Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.
    Introduction: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer that lacks durable responses to traditional chemotherapy. Areas covered: After MCC was shown to be an immunogenic tumor, small trials revealed high objective response rates to PD-1/PD-L1 checkpoint inhibitors. The JAVELIN Merkel 200 (NCT02155647) trial tested the use of avelumab, a human IgG1 monoclonal antibody against PD-L1, in metastatic MCC. Read More

    Phase I study of tomuzotuximab, a glycoengineered therapeutic antibody against the epidermal growth factor receptor, in patients with advanced carcinomas.
    ESMO Open 2018 1;3(2):e000303. Epub 2018 Feb 1.
    Department of Medical Oncology, Ospedale San Raffaele, Milano, Italy.
    Background: Changes in glycosylation of the constant domain (Fc) of monoclonal antibodies (mAbs) enhance antibody-dependent cell-mediated cytotoxicity independently of downstream effects following receptor blockade by the antibody, thus extending their indication. We investigated the safety, pharmacokinetics, pharmacodynamics and antitumour activity of tomuzotuximab, an IgG1 glycoengineered mAb against the epidermal growth factor receptor with enhanced tumour cytotoxicity in a phase I dose-escalation study (NTC01222637).

    Patients And Methods: Forty-one patients with advanced solid tumours refractory to standard therapies received tomuzotuximab weekly (12-1370 mg) or two-weekly (990 mg) on a three-plus-three dose escalation design. Read More

    The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility.
    J Biol Chem 2018 Mar 8;293(12):4582-4590. Epub 2018 Feb 8.
    From the School of Molecular and Cellular Biology,
    Ion channels regulate many aspects of cell physiology, including cell proliferation, motility, and migration, and aberrant expression and activity of ion channels is associated with various stages of tumor development, with K and Cl channels now being considered the most active during tumorigenesis. Accordingly, emerging and preclinical studies have revealed that pharmacological manipulation of ion channel activity offers protection against several cancers. Merkel cell polyomavirus (MCPyV) is a major cause of Merkel cell carcinoma (MCC), primarily because of the expression of two early regulatory proteins termed small and large tumor antigens (ST and LT, respectively). Read More

    Impact of baseline characteristics on outcomes of advanced HCC patients treated with sorafenib: a secondary analysis of a phase III study.
    J Cancer Res Clin Oncol 2018 Feb 17. Epub 2018 Feb 17.
    Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
    Background: The current study aims to investigate the impact of baseline characteristics on the outcomes of sorafenib-treated advanced Hepatocellular carcinoma (HCC) patients in the setting of a clinical trial.

    Methods: This is a secondary analysis of the comparator arm (sorafenib arm) of the NCT00699374 study which is a phase III multicenter study conducted between 2008 and 2010. The univariate probability of overall and progression-free survival was assessed among different patient subsets through Kaplan-Meier analysis and log-rank testing. Read More

    A phase I and pharmacokinetic study of taladegib, a Smoothened inhibitor, in Japanese patients with advanced solid tumors.
    Invest New Drugs 2018 Feb 17. Epub 2018 Feb 17.
    Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
    Background This phase I dose-escalation study investigated the safety of the Smoothened inhibitor taladegib in Japanese patients with advanced solid tumors. Methods Patients received taladegib orally once daily for 28-day cycles, using a 3 + 3 dose-escalation method. The primary objective was the safety and tolerability of taladegib at doses up to the global recommended dose (400 mg). Read More

    Parotid metastasis of renal cell carcinoma, mimicking primary clear cell oncocytoma: report of a case and brief review of the literature.
    Pathologica 2017 Dec;109(4):384-388
    Pathology Unit, ASST Valle Olona, Busto Arsizio, Italy.
    Malignancies of the parotid gland are relatively uncommon, accounting for only 3-6% of all head and neck cancers. Most of them are primary neoplasms, metastases are uncommon. Renal cell carcinoma (RCC) represents 3% of adult malignancies, the clear cell type comprises up to 70% of all RCC. Read More

    Cutaneous metastasis to the scalp as the primary presentation of colorectal adenocarcinoma.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    Baylor College of Medicine, Department of Dermatology, Houston, Texas.
    Eruptaneous metastasis is an uncommon presentation of colorectal adenocarcinoma that can occur years after diagnosis of the primary cancer or manifest as the first sign of malignancy. It is essential to diagnose these metastases immediately, as this late-stage development carries a poor prognosis. The scalp is one of the less common sites for skin metastases and nodules may be mistaken for benign entities. Read More

    Cabozantinib in Patients with Advanced Merkel Cell Carcinoma.
    Oncologist 2018 Feb 14. Epub 2018 Feb 14.
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
    Background: This study sought to determine the efficacy and safety profile of cabozantinib in patients with advanced Merkel cell carcinoma (MCC).

    Experimental Design: This prospective, phase II, single-institution trial enrolled patients with platinum-failure, recurrent/metastatic MCC to receive cabozantinib 60 mg orally daily until disease progression, withdrawal from study, or severe toxicity. The primary endpoint was disease control rate. Read More

    Eyelashes Trichomegaly: An Unusual Side Effect of Gefitinib Therapy.
    Int J Trichology 2018 Jan-Feb;10(1):44-46
    Department of Obstetrics and Gynecology, Baba Saheb Ambedkar Medical College and Hospital, New Delhi, India.
    Evolution of targeted therapy has changed the spectrum of treatment in oncology since the past two decades as lots of newer agents are being added to the pharmacologic armamentarium of cancer therapy. Epidermal growth factor receptor inhibitors form one such advancing field with many newer agents being investigated and they are used in wide variety of malignancies such as head and neck cancer, lung cancer, and even gastrointestinal malignancies such as pancreatic cancer. Various troublesome side effects of these agents include diarrhea, severe fatigability, severe skin rashes, and deranged liver function tests which may require treatment interruption or dose reduction resulting in decreased response to treatment. Read More

    Ulcerated Basal Cell Carcinomas Masquerading as Venous Leg Ulcers.
    Adv Skin Wound Care 2018 Mar;31(3):130-134
    Catherine N. Tchanque-Fossuo, MD, MS, is a Clinical Wound Fellow, at both the Department of Dermatology, University of California Davis, Sacramento, and the Dermatology Service, VA Northern California Health Care Systems, Mather, California. Jillian W. Millsop, MD, MS, is a Dermatology Resident, Department of Dermatology, University of California Davis, Sacramento, California. Mary Ann Johnson, MD, MS, is a Dermatologist, Mercy Medical Group-Dignity Health, El Dorado Hills, California. Sara E. Dahle, DPM, MPH, is Chief, Podiatry Section, Department of Surgery, VA Northern California Health Care Systems, Mather, and Assistant Professor, Department of Dermatology, University of California Davis, Sacramento, California. R. Rivkah Isseroff, MD, is Chief, Dermatology Service, VA Northern California Health Care Systems, Mather, and Professor, Department of Dermatology, University of California Davis, Sacramento, California. The authors have disclosed they have no financial relationships related to this article. Submitted January 15, 2017; accepted in revised form October 27, 2017.
    Background: Nonmelanoma skin cancers rarely arise from venous leg ulcers (VLUs). Although basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer, its association with lower-extremity ulcers is not as frequently reported as other malignancies.

    Objective: To report a case series of biopsy-proven BCC from lower-extremity ulcers of patients who presented at a multispecialty wound clinic. Read More

    Therapy-associated myelodysplastic syndrome with monosomy 7 arising in a Muir-Torre Syndrome patient carrying mutation.
    Mol Clin Oncol 2018 Feb 8;8(2):306-309. Epub 2017 Dec 8.
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
    Muir-Torre Syndrome (MTS) is a rare hereditary autosomal dominant cancer syndrome and is linked to hereditary non-polyposis colorectal carcinoma (Lynch Syndrome). Individuals develop various skin neoplasms in addition to colorectal, endometrial and upper gastrointestinal malignancies. Therapy-associated myelodysplastic syndrome (T-MDS) is an aggressive hematologic malignancy and is considered a pre-leukemic phase. Read More

    A randomized, multi-national, non-inferiority, phase III trial to evaluate the safety and efficacy of BF-200 ALA gel versus MAL cream in the treatment of non-aggressive basal cell carcinoma with photodynamic therapy (PDT).
    Br J Dermatol 2018 Feb 12. Epub 2018 Feb 12.
    Department of Dermatology and Allergology, Vest Clinic, Recklinghausen, Germany.
    Background: Basal cell carcinoma (BCC) represents the most common non-melanoma skin cancer worldwide affecting mainly adult, fair-skinned individuals. The WHO distinguishes aggressive and non-aggressive forms of which prototypical variants of the latter are primary nodular and superficial BCC.

    Objectives: To demonstrate non-inferiority of BF-200 ALA (a nanoemulsion gel containing 5-aminolaevulinic acid) compared to MAL (a cream containing methyl-aminolevulinate) in the treatment of non-aggressive BCC with photodynamic therapy (PDT). Read More

    GATA3 staining in primary cutaneous apocrine cribriform carcinoma: Usefulness to differentiate it from breast cancer metastasis.
    J Cutan Pathol 2018 May 12;45(5):348-351. Epub 2018 Mar 12.
    Dermatopathology Department, Dermatopathologie Friedrichshafen, Friedrichshafen, Germany.
    Background: Primary cutaneous apocrine cribriform carcinoma (PCACC) is a rare tumor, clinically appearing as a solitary nodule, mostly involving extremities of females and this lesion usually raises a differential diagnosis with metastatic cribriform carcinomas, especially breast cancer.

    Objective: To study GATA3 expression in a series of 14 primary cutaneous cribriform carcinomas and to test its usefulness to differentiate this tumor from metastatic breast cancer.

    Methods: We retrieved 14 cases with PCACC (each from a different patient) from the files of the authors. Read More

    Cutaneous Metastases from Salivary Duct Carcinoma of the Submandibular Gland.
    Case Rep Dermatol 2017 Sep-Dec;9(3):254-258. Epub 2017 Dec 5.
    Department of Plastic and Breast Surgery, Zealand University Hospital - Roskilde, Roskilde, Denmark.
    Salivary duct carcinoma is a rare and highly aggressive malignant neoplasm that frequently metastasises to other organs, but cutaneous metastasis is uncommon. There are only 6 cases reported in the literature with metastases to the skin and in all cases the tumour originates from the parotid gland. We present a case of skin metastases from the submandibular gland that was mistaken for basal cell carcinoma. Read More

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