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    8186 results match your criteria Metastatic Carcinoma of the Skin

    1 OF 164

    Supportive care for patients undergoing immunotherapy.
    Support Care Cancer 2017 Jul 13. Epub 2017 Jul 13.
    University of the Witwatersrand and Wits Donald Gordon Medical Center, Johannesburg, South Africa.
    Immune checkpoint inhibitors, a new class of cancer therapeutic agents, play an important role in the management of melanoma, NSCLC, and other malignancies. A workshop organized by three MASCC Study Groups: Oral Care, Skin Toxicities, and Neutropenia, Infection, and Myelosuppression during the MASCC Annual Meeting held in Adelaide, Australia on 23-25 June, 2016 focused on the new class of anti-cancer therapeutic agents. Topics in the workshop included the mechanism of action and clinical uses of immune anti-CTL4 and anti-PD1 antibodies, checkpoint inhibitor toxicities, including skin adverse events, gastrointestinal toxicities, oral complications, pulmonary toxicities, and endocrinological and immune-related infections. Read More

    Low incidence of metastasis and recurrence from cutaneous squamous cell carcinoma found in a UK population: Do we need to adjust our thinking on this rare but potentially fatal event?
    J Surg Oncol 2017 Jul 13. Epub 2017 Jul 13.
    St Marys Hospital Newport, Isle of Wight, United Kingdom.
    Background And Methods: Cutaneous squamous cell carcinoma (cSCC) is the commonest skin cancer with metastatic potential, however, reported rates of metastasis varies greatly. All cases of primary cSCC on the Isle of Wight between 2005 and 2014 were identified and retrospectively followed for recurrence and/or metastasis. Primary outcome was to identify the rate of metastasis/recurrence from cSCC. Read More

    Retiform Purpura After Transcatheter Arterial Chemoembolization: A Case Report.
    Am J Dermatopathol 2017 Jul 6. Epub 2017 Jul 6.
    *School of Medicine, Oregon Health and Science University, Portland, OR; and †Department of Dermatology, Oregon Health and Science University, Portland, OR.
    Cutaneous complications secondary to transcatheter arterial chemoembolization (TACE) are exceptionally rare and may occur because of nontarget embolization of terminal vessels supplying the skin. We present a patient who developed painful retiform purpura on the right flank shortly after TACE for treatment of hepatocellular carcinoma. Biopsy revealed intravascular tan to yellow amorphous spherical structures within the dermis, confirming the presence of foreign material within these vessels. Read More

    [Application of muscle pedicled platysma myocutaneous flap in the reconstruction of buccal mucosa defects].
    Hua Xi Kou Qiang Yi Xue Za Zhi 2017 Apr;35(2):162-166
    Centre of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China.
    Objective: This study aimed to explore the main features and advantages of the muscle pedicled platysma myocutaneous flap (PMF), the degree of improvement of flap harvest. To evaluate the application value of the flap in the reconstruction of buccal mucosa carcinoma defects.

    Methods: Twenty-three patients received PMF with MacFee incision to reconstruct buccal mucosa defects that were caused by the resection of precancer lesions and benign and malignant tumors from August 2012 to April 2015. Read More

    Metastatic triple-negative breast cancer patient with TP53 tumor mutation experienced 11 months progression-free survival on bortezomib monotherapy without adverse events after ending standard treatments with grade 3 adverse events.
    Cold Spring Harb Mol Case Stud 2017 Jul 5;3(4). Epub 2017 Jul 5.
    Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Schleswig-Holstein, D-24105 Kiel, Germany.
    A triple-negative breast cancer patient had no hereditary BRCA1, BRCA2, or TP53 risk variants. After exhaustion of standard treatments, she underwent experimental treatments and whole-exome sequencing of tumor, blood, and a metastasis. Well-tolerated experimental bortezomib monotherapy was administered for a progression-free period of 11 mo. Read More

    Metastatic cutaneous squamous cell carcinoma of the parotid gland: prognostic factors.
    J Laryngol Otol 2017 Jul 5:1-6. Epub 2017 Jul 5.
    Department of Otolaryngology Head and Neck Surgery,Christchurch Hospital,New Zealand.
    Background: Metastatic cutaneous squamous cell carcinoma is the most common parotid malignancy in Australasia. Prognostic indicators are not clearly defined and the extent of surgical resection required is controversial.

    Methods: A retrospective analysis was conducted of 63 patients who underwent surgery for metastatic cutaneous squamous cell carcinoma of the parotid gland at a tertiary hospital over a 10-year period. Read More

    Reconstruction of Cheek Defects Secondary to Mohs Microsurgery or Wide Local Excision.
    Facial Plast Surg Clin North Am 2017 Aug;25(3):443-461
    Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical Center, 1500 East Medical Center Drive SPC 5312, 1904 Taubman Center, Ann Arbor, MI 48109-5312, USA. Electronic address:
    Successful reconstruction of the cheek following excision for cutaneous malignancy requires careful consideration of defect location, size, and depth in relation to the anatomic properties of the affected cheek unit. Various reconstructive options are available to the surgeon, ranging from simple excisions to complex cervicofacial advancements to meet the needs for functional and aesthetically pleasing reconstructive outcomes. The surgeon must prevent distortion of mobile structures, such as the eyelid, nose, and lips; respect aesthetic subunits; and avoid blunting natural creases. Read More

    Giant desmoplastic cutaneous squamous cell carcinoma of the gluteal region.
    World J Surg Oncol 2017 Jul 4;15(1):121. Epub 2017 Jul 4.
    Department of Oncology,Faculty of Medicine, University Hospital Centre Zagreb, University of Zagreb, Zagreb, Croatia.
    Cutaneous squamous cell carcinoma (cSCC) is the most common type of skin tumour with the ability of metastatic spread. It represents about 20% of all malignancies diagnosed worldwide each year. Despite increased knowledge regarding the causes of skin cancer, the incidence of cSCC rises. Read More

    Characteristics of adverse drug reactions in a vemurafenib early post-marketing phase vigilance study in Japan.
    Clin Transl Oncol 2017 Jul 3. Epub 2017 Jul 3.
    Department of Dermatologic Oncology, National Cancer Center Hospital, Tokyo, Japan.
    Background: Post-approval research or monitoring is important to determine real-world safety of new products; however, evidence is scant for vemurafenib in Japanese patients. In Japan, a unique system is officially obligated to investigate post-approval safety. Here we report the first adverse drug reaction (ADR) data from vemurafenib-treated Japanese patients with metastatic melanoma. Read More

    PD-L1 expression predicts longer disease free survival in high risk head and neck cutaneous squamous cell carcinoma.
    Pathology 2017 Jun 27. Epub 2017 Jun 27.
    Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia; Central Clinical School, University of Sydney, Sydney, Australia. Electronic address:
    Programmed cell death (PD-1) and its ligand (PD-L1) inhibitors have shown clinical response in many tumours. PD-L1 data are limited in head and neck cutaneous squamous cell carcinoma (HNcSCC) and no clinical trials of PD-1/PD-L1 inhibitors are published. We performed PD-L1 immunohistochemistry on 74 cases of high risk HNcSCC with 38 matched metastases and evaluated clinicopathological associations, prognostic significance and heterogeneity in matched metastases. Read More

    F-18 FDG PET/CT Imaging of Eccrine Sweat Gland Carcinoma of the Scrotum with Extensive Regional and Distant Metastases.
    Asia Ocean J Nucl Med Biol 2017 ;5(2):104-108
    Department of Nuclear Medicine, Konyang University Hospital, Daejeon, Republic of Korea.
    Eccrine carcinoma is an extremely rare malignant skin cancer arising from eccrine sweat glands with a high metastatic potential. It mainly occurs in the elderly, with equal incidence in both sexes. It usually spreads to regional lymph nodes, with liver, lungs, and bones being the most common sites of distant metastasis. Read More

    Merkel cell carcinoma, melanoma, metastatic mimics of breast cancer.
    Semin Diagn Pathol 2017 May 31. Epub 2017 May 31.
    Stanford University School of Medicine, Dept of Pathology, L235 300 Pasteur Drive, Stanford, CA 94305, United States. Electronic address:
    Merkel cell carcinoma and melanoma can each occur primarily in breast skin, or metastasize to the breast. The breast is a rare site of metastasis of essentially any and every type of tumor, including carcinomas, sarcomas, and hematolymphoid neoplasms, and 10-30% of breast metastases may represent the initial presentation of disease. Although metastases generally recapitulate histologic features of the primary tumor, they are diagnostically challenging given their rarity and morphologic overlap with breast carcinoma, including special types of breast cancer. Read More

    Multiple papulonodular lesions on central area of the face: what is your diagnosis?
    Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.
    Department of Dermatology, Hospital de Santarém EPE, Santarém, Portugal.
    A healthy 31-year-old woman presented with a 20-year history of asymptomatic skin-colored papules and nodules on the central area of the face. Her maternal grandmother, aunts, mother, and sister also had similar lesions. Clinical, histopathological, and genetic features allowed the diagnosis of multiple familial trichoepithelioma. Read More

    Inoperable infiltrative basal cell carcinoma successfully treated with vismodegib.
    Dermatol Ther 2017 Jun 19. Epub 2017 Jun 19.
    Sina Pathobiology Laboratory, Rasht, Iran.
    Basal cell carcinoma (BCC) is the most common skin cancer but usually has a good prognosis. However, there is a subset of BCC cases with a less favorable prognosis. For patients with locally advanced, recurrent or metastatic BCCs who are not suitable for surgery or radiotherapy, small-molecule drug inhibitors of hedgehog pathway are a new therapeutic opportunity. Read More

    Concurrent BRAF and PTEN mutations in melanoma of unknown origin presenting as a breast mass.
    SAGE Open Med Case Rep 2017 31;5:2050313X17711064. Epub 2017 May 31.
    Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, FL, USA.
    Background: Metastases represent a small percentage of the malignancies affecting the breast, and only 5% of melanomas originate from non-cutaneous sites. Multiple genetic aberrations have been associated with the development of melanocytic lesions, including BRAF V600E mutation. Mutations in PTEN gene have also been related to the pathogenesis of multiple malignancies. Read More

    A new long noncoding RNA (LncRNA) is induced in cutaneous squamous cell carcinoma and downregulates several anticancer and cell-differentiation genes in mouse.
    J Biol Chem 2017 Jun 8. Epub 2017 Jun 8.
    Universite Cote d Azur-CNRS-IPMC, France.
    Keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Although some of the early events involved in this pathology have been identified, the subsequent steps leading to tumor development are poorly defined. We demonstrate here that the development of mouse tumors induced by the concomitant application of a carcinogen and a tumor promoter (7,12 dimethylbenz[a]anthracene [DMBA] and 12-O-tetradecanoylphorbol-13-acetate [TPA], respectively) is associated with the upregulation of a previously uncharacterized long noncoding RNA (lncRNA), termed AK144841. Read More

    Correlation Between Microvessel Density and Morphological Features in Skin Squamous Cell Carcinoma.
    Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Mar;38(1):63-73
    Macedonian Academy of Sciences and Arts, Skopje.
    Introduction: Abnormal angiogenesis is described in tumor growth and it facilitates its metastatic spread. Tumors with high angiogenic activity belong to the category of aggressive tumors with poor prognosis for patients. The aim of this study was to determine the blood vessels density (BVD), i. Read More

    Keratoacanthoma of the Nasal Septum Secondary to Ranibizumab Use.
    Case Rep Pathol 2017 11;2017:8257590. Epub 2017 May 11.
    Department of Otolaryngology-Head and Neck Surgery, Crozer-Chester Medical Center, One Medical Center Boulevard, Upland, PA, USA.
    Keratoacanthoma (KA) is a benign epithelial tumor that typically presents as a firm, cone-shaped, flesh-colored nodule with a central horn-filled crater. KA is considered to be a low-grade variant of squamous cell carcinoma (SCC). We report a rare case of a 72-year-old male who presented with a KA involving the nasal septum, possibly related to ranibizumab use. Read More

    Regorafenib for the treatment of unresectable hepatocellular carcinoma.
    Expert Rev Anticancer Ther 2017 Jul 9;17(7):567-576. Epub 2017 Jun 9.
    a Medical Oncology and Hematology Unit, Humanitas Cancer Center , Humanitas Clinical and Research Center , Rozzano ( Milan ), Italy.
    Introduction: Sorafenib is the standard of care for patients with advanced hepatocellular carcinoma (HCC) and well preserved liver function. However, until recent approval of regorafenib by the Food and Drug Administration (FDA), no effective therapeutic options were available for patients resistant to sorafenib. Areas covered: The present article reviews the preclinical and clinical data of regorafenib, putting them into the context of current and future landscape of treatment options for patients with HCC. Read More

    Deletion of tumor suppressors adenomatous polyposis coli and Smad4 in murine luminal epithelial cells causes invasive prostate cancer and loss of androgen receptor expression.
    Oncotarget 2017 May 17. Epub 2017 May 17.
    Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
    Prostate cancer is the most diagnosed non-skin cancer in the US and kills approximately 27,000 men per year in the US. Additional genetic mouse models are needed that recapitulate the heterogeneous nature of human prostate cancer. The Wnt/beta-catenin signaling pathway is important for human prostate tumorigenesis and metastasis, and also drives tumorigenesis in mouse models. Read More

    Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.
    Mol Carcinog 2017 Jun 2. Epub 2017 Jun 2.
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
    Basal cell carcinoma (BCC) of the skin is driven by aberrant hedgehog signaling. Thus blocking this signaling pathway by small molecules such as vismodegib inhibits tumor growth. Primary cilium in the epidermal cells plays an integral role in the processing of hedgehog signaling related proteins. Read More

    A Phase I Study of Combination Therapy with Sorafenib and 5-Fluorouracil in Patients with Advanced Hepatocellular Carcinoma.
    Drugs R D 2017 Jun 1. Epub 2017 Jun 1.
    Division of Gastroenterology and Hepatology, Hokkaido University Hospital, Kita 15 Nishi 7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.
    Background And Aims: Sorafenib is the first molecular targeted drug approved for the treatment of advanced hepatocellular carcinoma (HCC) and is a potent small molecule inhibitor of multiple kinases. Combination therapy with sorafenib and other cytotoxic agents for HCC may result in additive anticancer activity. The purpose of this phase I study was to investigate the safety and tolerability of combination therapy with sorafenib and 5-fluorouracil (5-FU) and to determine the optimum dose of 5-FU for a phase II trial. Read More

    Spiradenocarcinoma: A Comprehensive Data Review.
    Am J Dermatopathol 2017 May 16. Epub 2017 May 16.
    *Research Fellow, Department of Visceral- and Transplant Surgery, University Hospital of Zurich, Zurich, Switzerland; †Senior Physician, Department of Pathology, Triemli Hospital, Zurich, Switzerland; ‡Senior Physician, Department of Oncology, Limmattal Hospital, Zurich-Schlieren, Switzerland; §Senior Physician, Department of Surgery, Limmattal Hospital, Zurich-Schlieren, Switzerland; and ¶Director and Chief Physician, Department of Surgery, Limmattal Hospital, Zurich-Schlieren, Switzerland.
    Introduction: Spiradenocarcinomas (SCs) are rare and potentially aggressive skin adnexal tumors. Optimal treatment has not yet been established. Experiences with this carcinoma are mostly presented in case reports and few case series. Read More

    Basal cell carcinoma: 10-year experience with electrochemotherapy.
    J Transl Med 2017 May 31;15(1):122. Epub 2017 May 31.
    Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padova, Padua, Italy.
    Background: Electrochemotherapy (ECT), by combining manageable cytotoxic agents with short electric pulses, represents an effective palliative skin-directed therapy. The accumulated evidence indicates that ECT stands out as a safe and well-tolerated alternative treatment for patients with multiple or large basal cell carcinoma (BCC), who are not suitable for conventional treatments. However, long-term data and shared indications are lacking. Read More

    Comorbidity between HTLV-1-associated adult T-cell lymphoma/leukemia and verrucous carcinoma: a case report.
    Colomb Med (Cali) 2017 Mar 30;48(1):35-38. Epub 2017 Mar 30.
    Escuela de Medicina Facultad de Salud, Universidad del Valle Cali, Colombia.
    Background: Adult T-cell Leukemia/Lymphoma (ATLL) is classified as a peripheral CD4+ T-cell neoplasm caused by the human T-cell lymphotropic virus type 1 (HTLV-1). Typical symptoms are associated with leukemic infiltration; however, atypical and exaggerated manifestations of verrucous carcinoma have also been described.

    Case Report: We present here the case of a patient with multiple skin lesions, ischemic necrosis in the hallux and lymphadenopathies. Read More

    Primary cutaneous perivascular epithelioid cell tumor (PEComa): Five new cases and review of the literature.
    J Cutan Pathol 2017 May 30. Epub 2017 May 30.
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
    PEComas represent a family of uncommon mesenchymal tumors composed of "perivascular epithelioid cells" with a distinct immunophenotype that typically shows both myogenic and melanocytic differentiation. The PEComa family includes angiomyolipoma (AML), clear cell "sugar" tumor of the lung and extra pulmonary sites, lymphangioleiomyomatosis and clear cell myomelanocytic tumor of the falciform ligament/ligamentum teres. Very rarely, PEComas may arise in the skin. Read More

    Postrenal Transplant Metastatic Colonic Neoplasm: Posttransplant Lymphoproliferative Disorder or Adenocarcinoma?
    Indian J Nephrol 2017 May-Jun;27(3):218-221
    Department of Nuclear Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
    Transplant recipients are vulnerable to a horde of infections and neoplastic conditions due to immunosuppression. Posttransplant lymphoproliferative disorder (PTLD) is a condition unique to the transplant recipient occurring due to monoclonal lymphocytic proliferation. It may affect any organ system with reportedly highest incidence in the gastrointestinal tract. Read More

    Frequency and locations of systemic metastases in Merkel cell carcinoma by imaging.
    Acta Radiol Open 2017 Mar 24;6(3):2058460117700449. Epub 2017 Mar 24.
    Medical Imaging Center, Helsinki University Hospital, Helsinki, Finland.
    Background: The primary neuroendocrine skin cancer, Merkel cell carcinoma (MCC), has a well-known predilection to metastasize systemically. However, the experience of systemic metastases in MCC is mainly disseminated through case reports due to the rarity of MCC.

    Purpose: To elucidate the frequency and locations of systemic metastasis in MCC by reviewing the imaging of patients with metastatic MCC in a national cohort. Read More

    "Clown nose" as first manifestation of squamous cell carcinoma of the lung.
    J Dermatol Case Rep 2017 Mar 31;11(1):9-11. Epub 2017 Mar 31.
    Department of Dermatology, IDIBELL, Hospital de Bellvitge, University of Barcelona, Barcelona, Spain.
    Background: Skin metastases occur in 0.7% to 9% of all patients with cancer and are usually considered a late event in the evolution of most visceral carcinomas. The development of a nodular metastatic lesion on the nasal tip is known as clown nose sign. Read More

    Ductal eccrine carcinoma of the axilla: a diagnostic pitfall.
    An Bras Dermatol 2017 Mar-Apr;92(2):239-242
    Department of Dermatology, Instituto Português de Oncologia de Lisboa - Lisboa, Portugal.
    Ductal eccrine carcinoma (DEC) is a rare sweat gland carcinoma with ductular differentiation. Clinically, it is characterized by a slowly growing, hardened plaque or nodule predominantly located on the head and neck. Histologically, DEC shares similar features to invasive breast carcinoma, thus causing great diagnostic challenges. Read More

    A nodule on the scalp as the first sign of extranodal disease in medullary thyroid carcinoma.
    Dermatol Online J 2017 May 15;23(5). Epub 2017 May 15.
    Department of Dermatology, Hospital Universitari de Bellvitge, Barcelona, Spain.
    Medullary carcinoma of the thyroid gland accounts for only 5-10% of thyroid carcinomas. Also, metastases to the skin of malignant tumors are infrequently (2-9% of patients). In the case herein reported in a 64-year old woman, a metastatic nodule on the scalp was the presenting clinical manifestation of a medullary thyroid carcinoma. Read More

    FDA Approval Summary: Pembrolizumab for the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma with Disease Progression on or After Platinum-Containing Chemotherapy.
    Oncologist 2017 Jul 22;22(7):873-878. Epub 2017 May 22.
    Office of Hematology and Oncology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
    On August 5, 2016, the U.S. Food and Drug Administration granted accelerated approval to pembrolizumab (KEYTRUDA injection, Merck Sharp & Dohme Corp. Read More

    A single-center experience of sorafenib monotherapy in patients with advanced intrahepatic cholangiocarcinoma.
    Oncol Lett 2017 May 13;13(5):2957-2964. Epub 2017 Mar 13.
    Department of Hepatic Surgery, Affiliated Provincial Hospital of Anhui Medical University, Hefei, Anhui 230001, P.R. China.
    Patients with advanced intrahepatic cholangiocarcinoma (ICC) have a poor prognosis and the therapeutic options available for treating ICC are limited. Sorafenib, a multikinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet derived growth factor receptor-β, B-Raf proto-oncogene, serine/threonine kinase and C-Raf proto-oncogene, serine/threonine kinase, is a novel reference standard for the treatment of advanced hepatocellular carcinoma. Sorafenib has previously been demonstrated to exhibit significant antitumor activity in various cholangiocarcinoma cell lines and in xenograft ICC models. Read More

    Tumor cell-specific AIM2 regulates growth and invasion of cutaneous squamous cell carcinoma.
    Oncotarget 2017 Jul;8(28):45825-45836
    Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland.
    Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Inflammation is a typical feature in cSCC progression. Analysis of the expression of inflammasome components in cSCC cell lines and normal human epidermal keratinocytes revealed upregulation of the expression of AIM2 mRNA and protein in cSCC cells. Read More

    An immunohistochemical analysis of lymphocytic infiltrations in canine skin cancers.
    Pol J Vet Sci 2017 Mar;20(1):141-147
    Lymphocytic infiltrations located in the extracellular matrix often accompany canine skin cancer. They can be characterised as an inflammatory infiltration and/or a second tumour - lymphoma. The aim of this study was an immunohistochemical analysis of a lymphocytic infiltration which accompanies spontaneous skin cancer. Read More

    Expression of PD-L1 in keratoacanthoma and different stages of progression in cutaneous squamous cell carcinoma.
    Cancer Immunol Immunother 2017 May 13. Epub 2017 May 13.
    Skin Cancer Center of the Department of Dermatology, St. Josef Hospital, Ruhr-University Bochum, Gudrunstr. 56, 44791, Bochum, Germany.
    Background: Programmed cell death 1 (PD-1) and its ligands (PD-L1) play a major role in the immune responses of a variety of cancers.

    Objectives: To investigate the expression of PD-L1 in different progression forms of cutaneous squamous cell carcinoma (cSCC) and keratoacanthoma (KA).

    Methods: We performed immunohistochemical staining of 21 KA, 26 actinic keratoses (AK), 20 Bowen´s diseases (BD), and 26 high-risk cSCC. Read More

    Open-label, multicentre safety study of vemurafenib in 3219 patients with BRAF(V600) mutation-positive metastatic melanoma: 2-year follow-up data and long-term responders' analysis.
    Eur J Cancer 2017 Jul 11;79:176-184. Epub 2017 May 11.
    Cancer Clinical Trials Unit, Royal Adelaide Hospital, Adelaide, Australia; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, Australia; Discipline of Medicine, University of Adelaide, Adelaide, Australia. Electronic address:
    Background: The orally available BRAF kinase inhibitor vemurafenib is an effective and tolerable treatment option for patients with metastatic melanoma harbouring BRAF(V600) mutations. We assessed the safety of vemurafenib in a large population of patients with few alternative treatment options; we report updated 2-year safety.

    Methods: This was an open-label, multicentre study of vemurafenib (960 mg bid) in patients with previously treated or untreated BRAF mutation-positive metastatic melanoma (cobas(®) 4800 BRAF V600 Mutation Test). Read More

    The cost of major head and neck cancer surgery.
    N Z Med J 2017 May 12;130(1455):111-119. Epub 2017 May 12.
    Wellington Regional Plastic, Maxillofacial and Burns Unit, Hutt Hospital; and Gillies McIndoe Research Institute, Wellington.
    Aim: This study quantified the cost of major head and neck cancer (HNC) surgery.

    Methods: Consecutive patients undergoing major HNC surgery between July 2007 and June 2012 were identified from our head and neck database. Patient demographics, tumour type, site, stage and types of resection and reconstruction, length of stay and surgical complications occurring within six months of initial surgery were retrospectively analysed. Read More

    Estrogen receptor-positive primary squamous cell carcinoma of the breast.
    Radiol Case Rep 2017 Jun 4;12(2):211-214. Epub 2017 Feb 4.
    Department of Diagnostic Radiology, Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612, USA.
    Pure primary squamous cell carcinoma of the breast (SCCB) represents around 0.1% of breast carcinomas. Diagnosis requires independence from adjacent skin without metastatic disease. Read More

    Breast metastases from extramammary malignancies: multimodality imaging aspects.
    Br J Radiol 2017 May 25:20170197. Epub 2017 May 25.
    1 Department of Imaging, AC Camargo Cancer Center, São Paulo, São Paulo, Brazil.
    Breast metastases from extramammary cancers are rare and usually related to poor prognosis. The extramammary tumours most frequently exhibiting breast metastases are melanoma, lymphomas, ovarian cancer, lung and neuroendocrine tumours, and sarcomas. Owing to the lack of reliable and specific clinical or radiological signs for the diagnosis of breast metastases, a combination of techniques is needed to differentiate these lesions from primary breast carcinoma or even benign breast lesions. Read More

    Unusual asymptomatic presentation of bladder cancer metastatic to the penis.
    Pathol Res Pract 2017 Jun 2;213(6):717-720. Epub 2016 Dec 2.
    Department of Histology and Molecular Pathology, Careggi Hospital, University of Florence, Largo Brambilla, 3, 50134 Florence, Italy.
    Penile metastasis is an extremely rare event and mainly originate from primary pelvic tumor sites such us urinary bladder, gastro-intestinal tract and prostate and more rarely from respiratory system, bone tumors and melanoma. Here we describe the unusual presentation of two bladder urothelial cancer metastatic to the penis with no relevant clinical symptoms. Namely, a 69 years-old man with a warthy lesions of the foreskin and the glans misunderstood for a condylomata that at histological and immunohistochemical analysis showed a bladder urothelial carcinoma; and a 71 years-old man with reddish skin lesion of the glans, a previous history of bladder and urethral carcinoma and histological pagetoid spread of urothelial cancer to the glans. Read More

    A case of HER2-positive male occult breast carcinoma with skin and lymph node metastases that exhibited complete response to trastuzumab monotherapy.
    Clin Case Rep 2017 May 17;5(5):591-593. Epub 2017 Mar 17.
    Division of Digestive and General SurgeryRyukyu University Graduate School of MedicineOkinawaJapan.
    Metastatic male occult HER2-positive breast cancer can be successfully treated with trastuzumab monotherapy. Read More

    The PP4R1 sub-unit of protein phosphatase PP4 is essential for inhibition of NF-κB by merkel polyomavirus small tumour antigen.
    Oncotarget 2017 Apr;8(15):25418-25432
    School of Molecular and Cellular Biology, Faculty of Biological Sciences, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.
    Merkel cell carcinoma (MCC) is a highly aggressive skin cancer with a high metastatic potential. The majority of MCC cases are caused by the Merkel cell polyomavirus (MCPyV), through expression of the virus-encoded tumour antigens. Whilst mechanisms attributing tumour antigen expression to transformation are being uncovered, little is known of the mechanisms by which MCPyV persists in the host. Read More

    Non-melanoma skin cancer: new and future synthetic drug treatments.
    Expert Opin Pharmacother 2017 May 17;18(7):689-699. Epub 2017 Apr 17.
    a Center for Dermatooncology, Department of Dermatology , University Hospital Tübingen , Tübingen , Germany.
    Introduction: Non-melanoma skin cancers (NMSC) mainly comprise two different entities: basal cell carcinoma (BCC) and squamous cell carcinoma (SCC); beneath these two entities, Merkel cell carcinoma, adnexal tumors, dermatofibrosarcoma protuberans, angiosarcoma, and cutaneous lymphoma belong to NMSC. These rare skin tumors are not the topic of this review. BCC and SCC are the most common cancers diagnosed in humans. Read More

    CYFIP1 is directly controlled by NOTCH1 and down-regulated in cutaneous squamous cell carcinoma.
    PLoS One 2017 14;12(4):e0173000. Epub 2017 Apr 14.
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    Squamous cell carcinoma of the skin (SCC) represents one of the most common cancers in the general population and is associated with a substantial risk of metastasis. Previous work uncovered the functional role of CYFIP1 in epithelial tumors as an invasion inhibitor. It was down-regulated in some cancers and correlated with the metastatic properties of these malignant cells. Read More

    Local treatment of a pharyngocutaneous fistula secondary to osteoradionecrosis.
    Enferm Clin 2017 May - Jun;27(3):193-202. Epub 2017 Apr 11.
    Servicio de Digestivo y Otorrinolaringología, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, España. Electronic address:
    Radionecrosis is a late, and difficult to treat,complication of radiotherapy performed on head and neck tumours, and it is difficult to treat. This process causes significant damage, not only in the skin, but also in muscular, nervous, vascular, and bone structures. This, in turn, leads to airway and digestive tract involvement, as well as a functional loss and a cosmetic defect that usually requires reconstructive surgery. Read More

    MGMT promoter methylation status in Merkel cell carcinoma: in vitro versus invivo.
    J Cancer Res Clin Oncol 2017 Aug 12;143(8):1489-1497. Epub 2017 Apr 12.
    Department of Translational Skin Cancer Research (tscr), University Hospital Essen, Universitätstraße 1, 45141, Essen, Germany.
    Purpose: Expression of O6-methylguanine-DNA methyltransferase (MGMT) in Merkel cell carcinoma (MCC) is very variable; thus, we tested whether this may be due to differential methylation of the MGMT gene promoter.

    Methods: Quantitative analysis of MGMT mRNA and protein expression, as well as MGMT promoter methylation status, was performed in a series of tissue samples of MCC tumors, representing both primary and metastatic lesions, as well as in six MCC cell lines.

    Results: These analyses revealed a very heterogeneous MGMT mRNA and protein expression in MCC both in vivo and in vitro. Read More

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