8,944 results match your criteria Metastatic Carcinoma of the Skin


Nasopharyngeal carcinoma with cutaneous metastases.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of radiotherapy, Farhat Hached hospital, Sousse, Tunisia.

Introduction: Cutaneous metastases from nasopharyngeal carcinoma are extremely rare and associated with a poor prognosis.

Case Reports: We retrospectively reviewed 820 patients with nasopharyngeal carcinoma treated over a 20-year period in the radiotherapy department of Farhat Hached hospital in Sousse and Ibn Khaldoun Medical centre, Hammam Sousse. Two of these patients presented cutaneous metastases. Read More

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http://dx.doi.org/10.1016/j.anorl.2019.04.005DOI Listing
April 2019
2 Reads

MHC class-I downregulation in PD-1/PD-L1 inhibitor refractory Merkel cell carcinoma and its potential reversal by histone deacetylase inhibition: a case series.

Cancer Immunol Immunother 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, University Clinic Essen, Essen, Germany.

Background: Merkel cell carcinoma (MCC) is an aggressive skin cancer in which PD-1/PD-L1 blockade has shown remarkable response rates. However, a significant proportion of patients shows primary or secondary resistance against PD-1/PD-L1 inhibition, with HLA class-I downregulation and insufficient influx of CD8 T cells into the tumor as possible immune escape mechanisms. Histone deacetylase inhibitors (HDACi) have been demonstrated to reverse low HLA class-I expression caused by epigenetic downregulation of the antigen machinery (APM) in vitro and in pre-clinical models in vivo. Read More

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http://dx.doi.org/10.1007/s00262-019-02341-9DOI Listing
April 2019
1 Read

Detection and quantification of VEGFR-1 in the nuclei of tumor cells by a new flow cytometry-based method.

J Immunotoxicol 2019 Dec;16(1):74-81

a Laboratory of Experimental Diagnostics and Biotherapy of Tumors, Research Institute of Experimental Diagnostics and Therapy of Tumors, N. N. Blokhin National Medical Research Center of Oncology , Ministry of Health of Russia , Moscow , Russia.

Flow cytometry using fluorescent antibodies (FC) is the method of choice for the quantitation of proteins expressed at the surface or inside the cell, but, however, does not allow to selectively measure nuclear expression. We therefore sought to develop a method for the extraction of intact cell nuclei, which can be used for their subsequent immunofluorescent analysis by FC. The studied protein was vascular endothelial growth factor-receptor-type 1 (VEGFR-1) which is important in tumor survival and metastasis. Read More

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http://dx.doi.org/10.1080/1547691X.2019.1598522DOI Listing
December 2019
4 Reads

Evaluating the trend of cutaneous malignant tumors in Ilam from 2002 to 2011.

J Family Med Prim Care 2019 Feb;8(2):717-721

Department of Cardiology, Ilam University of Medical Sciences, Ilam, Iran.

Introduction: Skin cancer, the melanoma type of which causes high mortality, is the most common malignancy in Iran and all over the world. UV is the most important cause of the incidence of this disease. This study evaluates the frequency of different types of cancer and their trajectory in Ilam province from 2012 to 2011. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_178_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436317PMC
February 2019
3 Reads

Palliative Radiation Therapy for Vertebral Metastases and Metastatic Cord Compression in Patients Treated With Anti-PD-1 Therapy.

Front Oncol 2019 29;9:199. Epub 2019 Mar 29.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

There is increasing use of immune checkpoint blockade (ICB) across multiple cancer types, including in patients at risk for vertebral metastases and cord compression. These patients are often treated with palliative radiotherapy (PRT); however, data evaluating the combination of PRT and ICB in patients with vertebral metastases is limited. Furthermore, patients with cord compression are generally excluded from prospective clinical trials. Read More

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http://dx.doi.org/10.3389/fonc.2019.00199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450051PMC
March 2019
2 Reads

A rare case of Merkel cell carcinoma with ovarian metastasis.

Gynecol Oncol Rep 2019 May 20;28:76-78. Epub 2019 Mar 20.

Gynecology and Obstetrics, Hospital Grabs, Spitalstrasse 44, CH-9472 Grabs, Switzerland.

Introduction: Merkel cell carcinoma (MCC) is a rare cutaneous malignancy that normally occurs in sun-exposed areas of the skin. Risk factors are immundeficency and Merkel cell polyomavirus.Treatment options are surgery, radiotherapy, chemotherapy and immunotherapy in clinical trials. Read More

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http://dx.doi.org/10.1016/j.gore.2019.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434058PMC
May 2019
1 Read

Recent Therapeutic Advances and Change in Treatment Paradigm of Patients with Merkel Cell Carcinoma.

Oncologist 2019 Apr 8. Epub 2019 Apr 8.

Medical Oncology Department, University General Hospital of Valencia, Valencia, Spain.

Merkel cell carcinoma (MCC) is a rare, aggressive, primary cutaneous neuroendocrine tumor that typically presents as an indurated nodule on sun-exposed areas of the head and neck in the white population. Major risk factors include immunosuppression, UV light exposure, and advanced age. Up to 80% of MCC are associated with Merkel cell polyomavirus. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0718DOI Listing
April 2019
1 Read

A phase 1b study evaluating the safety and pharmacokinetics of regorafenib in combination with cetuximab in patients with advanced solid tumors.

Int J Cancer 2019 Apr 8. Epub 2019 Apr 8.

University of Southern California/Norris Comprehensive Center, Los Angeles, CA.

Regorafenib 160 mg orally once daily (QD) 3 weeks on/1 week off is approved in colorectal cancer, gastrointestinal stromal tumors, and hepatocellular carcinoma. We established the safety and pharmacokinetics (PK) of regorafenib combined with cetuximab in advanced refractory solid tumors. This was a phase 1, open-label, dose-escalation study (NCT01973868) in patients with advanced/metastatic solid tumors who progressed after standard therapy. Read More

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http://dx.doi.org/10.1002/ijc.32317DOI Listing
April 2019
3 Reads

Chromosome 3q arm gain linked to immunotherapy response in advanced cutaneous squamous cell carcinoma.

Eur J Cancer 2019 Apr 4;113:1-9. Epub 2019 Apr 4.

Medical Oncology, Dana-Farber Cancer Institute, USA. Electronic address:

Aims: The activity that the immune checkpoint inhibitor (ICI) cemiplimab has recently demonstrated has led to a paradigm shift in the management of patients with advanced cutaneous squamous cell carcinoma (cSCC). To identify predictive biomarkers of response to ICIs in advanced cSCC, we studied 33 patients who received ICI therapy at the Dana-Farber/Harvard Cancer Center (DF/HCC) and analysed sequencing data for a subset of these patients.

Methods: We collected clinical data using electronic health records and genomic data using the institutional OncoPanel platform of the DF/HCC. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.03.004DOI Listing
April 2019
2 Reads

Safety and clinical activity of the Notch inhibitor, crenigacestat (LY3039478), in an open-label phase I trial expansion cohort of advanced or metastatic adenoid cystic carcinoma.

Invest New Drugs 2019 Apr 6. Epub 2019 Apr 6.

Drug Development Department (DITEP), Institut Gustave Roussy Cancer Campus, 114 rue Edouard Vaillant, 94800, Villejuif Cedex, France.

Background Deregulated Notch signaling is implicated in multiple cancers. The phase I trial (I6F-MC-JJCA) investigated the safety and anti-tumor activity of crenigacestat (LY3039478), a selective oral Notch inhibitor, in an expansion cohort of patients with adenoid cystic carcinoma (ACC) who received the dose-escalation-recommended phase 2 dose (RP2D), established previously (Massard C, et al., Annals Oncol 2018, 29:1911-17). Read More

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http://link.springer.com/10.1007/s10637-019-00739-x
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http://dx.doi.org/10.1007/s10637-019-00739-xDOI Listing
April 2019
9 Reads

Heterogeneity of PD-L1 expression and CD8 tumor-infiltrating lymphocytes among subtypes of cutaneous adnexal carcinomas.

Cancer Immunol Immunother 2019 Apr 5. Epub 2019 Apr 5.

Pathology Department, INSERM UMR_S1165, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris (APHP), 1 Avenue Claude Vellefaux, 75010, Paris, France.

Background: Adnexal carcinomas are rare and heterogeneous skin tumors, for which no standard treatments exist for locally advanced or metastatic tumors.

Aim Of The Study: To evaluate the expression of PD-L1 and CD8 in adnexal carcinomas, and to study the association between PD-L1 expression, intra-tumoral T cell CD8 infiltrate, and metastatic evolution.

Materials And Methods: Eighty-three adnexal carcinomas were included. Read More

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http://link.springer.com/10.1007/s00262-019-02334-8
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http://dx.doi.org/10.1007/s00262-019-02334-8DOI Listing
April 2019
3 Reads

Squamous Cell Carcinoma Larynx with Malignant Ascites: a Rare Entity.

Indian J Surg Oncol 2019 Mar 26;10(1):210-212. Epub 2018 Nov 26.

Department: Surgical Oncology and Pathology, Bhagwan Mahaveer Cancer Hospital and Research Center, JLN Road, Jaipur, Rajasthan 302017 India.

Usual sites of the spread of the squamous cell carcinoma (SCC) larynx is regional-cervical lymphadenopathy. The lung is the most frequent site of distant metastasis, accounting for 66% of distant metastasis. Other metastatic sites include bone (22%), liver (10%), skin, mediastinum, and bone marrow. Read More

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http://dx.doi.org/10.1007/s13193-018-0828-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414568PMC
March 2019
1 Read

Inflammation: A key process in skin tumorigenesis.

Oncol Lett 2019 May 19;17(5):4068-4084. Epub 2018 Nov 19.

Department of Pathology, Colentina Clinical Hospital, 020125 Bucharest, Romania.

The extremely delicate shift from an inflammatory process to tumorigenesis is a field of major scientific interest. While the inflammation induced by environmental agents has well known underlying mechanisms, less is known concerning the oncogenic changes that follow an inflammatory chronic status in the tissue microenvironment that can lead to pro-tumorigenic processes. Regardless of the origin of the environmental factors, the maintenance of an inflammatory microenvironment is a clear condition that favors tumorigenesis. Read More

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http://dx.doi.org/10.3892/ol.2018.9735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444305PMC
May 2019
2 Reads

Idiopathic Granulomatous Mastitis - a new approach in diagnostics and treatment.

Neoplasma 2019 Mar 31;2019. Epub 2019 Mar 31.

Department of Pathology, St. Elizabeth Cancer Institute, Bratislava, Slovakia.

Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease mimicking carcinoma and puerperal or non-puerperal mastitis. The primary purpose of this prospectively performed case control study was to compare clinical and imaging signs of IGM with the reference group of nonspecific, non- puerperal mastitis (NM) to identify the most typical clinical and imaging signs essential for a correct differential diagnosis. The secondary purpose was to present a new approach to non-invasive treatment. Read More

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http://dx.doi.org/10.4149/neo_2019_190201N100DOI Listing

Undifferentiated Sarcoma as Intermediate Step in Rhabdomyosarcomatous Transformation of a Metastatic Malignant Melanoma Resistant to Anti-BRAF Therapy: A Phenomenon Associated With Significant Diagnostic and Therapeutic Pitfalls.

Authors:
Tien Anh N Tran

Int J Surg Pathol 2019 Apr 3:1066896919839143. Epub 2019 Apr 3.

1 Florida Orlando Hospital, Orlando, FL, USA.

Undifferentiated sarcoma has been hypothesized as an intermediate step in the progression of malignant melanoma to rhabdomyosarcoma. The current report describes a new case of rhabdomyosarcomatous transformation in a malignant melanoma and documents the temporal progression of the malignant melanoma to rhabdomyosarcoma in different metastatic sites via undifferentiated sarcoma. A 65-year-old female with a past medical history of malignant melanoma presented with a new lung mass. Read More

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http://dx.doi.org/10.1177/1066896919839143DOI Listing
April 2019
6 Reads

An Unusual Presentation of Merkel Cell Carcinoma in a HIV Patient: A Case Report and Literature Review.

J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619836695

1 Brookdale University Hospitals and Medical Center, New York, NY, USA.

Merkel cell carcinoma (MCC) is a rare, rapidly growing, aggressive neuroendocrine skin cancer that generally arises on sun-exposed areas of body such as head, neck, upper limbs, and shoulders of people with light complexity. Typically, MCC presents as shiny, flesh-colored or bluish-red, intracutaneous nodule, possibly with ulceration or crusting. In most of the cases, there is an association with Merkel cell polyomavirus. Read More

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http://dx.doi.org/10.1177/2324709619836695DOI Listing
April 2019
3 Reads

Five-year outcome of ultrasound-guided interstitial permanent I seeds implantation for local head and neck recurrent tumors: a single center retrospective study.

J Contemp Brachytherapy 2019 Feb 28;11(1):28-34. Epub 2019 Feb 28.

Department of Radiation Oncology, Peking University Third Hospital, Beijing.

Purpose: The aim of this study was to evaluate the efficacy and safety of interstitial permanent low-dose-rate ultrasound-guided I seeds implantation of local head and neck recurrent tumors.

Material And Methods: Sixty-four consecutive patients, with 81 lesions in total, underwent permanent implantation of I seeds under ultrasound guidance. Post-operative dosimetry was performed for all patients. Read More

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http://dx.doi.org/10.5114/jcb.2019.83336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431107PMC
February 2019
3 Reads

Double trouble: two cases of dual adrenal pathologies in one adrenal mass.

Endocrinol Diabetes Metab Case Rep 2019 Mar 23;2019. Epub 2019 Mar 23.

St. Vincent's University Hospital and University College Dublin, Dublin, Ireland.

Context Adrenal incidentalomas (AI) represent an increasingly common problem in modern endocrine practice. The diagnostic approach to AIs can be challenging and occasionally reveals surprising features. Here we describe two rare cases of complex adrenal lesions consisting of phaeochromocytomas with synchronous metastases from extra-adrenal primaries. Read More

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http://dx.doi.org/10.1530/EDM-18-0151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432979PMC
March 2019
1 Read

Anlotinib Versus Sunitinib as First-Line Treatment for Metastatic Renal Cell Carcinoma: A Randomized Phase II Clinical Trial.

Oncologist 2019 Mar 22. Epub 2019 Mar 22.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China

Background: Anlotinib is a tyrosine kinase inhibitor inhibiting angiogenesis. This multicenter, randomized phase II trial aimed to investigate the efficacy and safety of anlotinib in comparison with sunitinib as first-line treatment for patients with metastatic renal cell carcinoma (mRCC).

Materials And Methods: Patients with mRCC from 13 clinical centers were randomly assigned in a 2:1 ratio to receive anlotinib ( = 90) or sunitinib ( = 43). Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0839DOI Listing
March 2019
2 Reads
4.865 Impact Factor

Epidemiology and survival of Merkel cell carcinoma in New Zealand: A population-based study between 2000 and 2015 with international comparison.

Australas J Dermatol 2019 Mar 21. Epub 2019 Mar 21.

Auckland Regional Plastic, Reconstructive & Hand Surgery Unit, Auckland, New Zealand.

Background/objectives: Merkel cell carcinoma is an aggressive neuroendocrine skin cancer. Australian studies report high incidence and poor survival rates compared internationally. While New Zealand has a comparable UV index and racial composition to Australia, survival outcomes are currently unknown. Read More

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http://dx.doi.org/10.1111/ajd.13023DOI Listing
March 2019
1 Read

Cutaneous Tumour of the Left Cricothyroid Area!?

Open Access Maced J Med Sci 2019 Feb 25;7(4):698-699. Epub 2019 Feb 25.

Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic surgery, General Skobelev 79, 1606 Sofia.

Background: The cricothyroid area is an atypical localisation for placement of basal cell carcinomas. The main differential diagnosis for cutaneous tumours in this area is between BCC, spinocellular carcinoma and melanoma. The area is problematic about the choice of therapeutic approach, especially in the case of a vague clinical tumour type accompanied by enlarged lymph nodes in the immediate proximity. Read More

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http://dx.doi.org/10.3889/oamjms.2019.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420945PMC
February 2019
1 Read

Substitution of low-risk skin cancer hospital care towards primary care: A qualitative study on views of general practitioners and dermatologists.

PLoS One 2019 19;14(3):e0213595. Epub 2019 Mar 19.

Department of Dermatology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

Background: Rising healthcare expenditures places the potential for substitution of hospital care towards primary care high on the political agenda. As low-risk basal cell carcinoma (BCC) care is one of the potential targets for substitution of hospital care towards primary care the objective of this study is to gain insight in the views of healthcare professionals regarding substitution of skin cancer care, and to identify perceived barriers and potential strategies to facilitate substitution.

Methods: A qualitative study was conducted consisting of 40 interviews with dermatologists and GPs and three focus groups with 18 selected GPs with noted willingness regarding substitution of skin cancer care. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213595PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424446PMC
March 2019
1 Read

Seed and soil? - Pharyngeal Merkel cell carcinoma after radiotherapy for laryngeal squamous cell carcinoma.

Am J Otolaryngol 2019 Mar 9. Epub 2019 Mar 9.

Department of Otolaryngology - Head and Neck Surgery, University of Iowa Hospitals and Clinics, 21151 Pomerantz Family Pavilion, 200 Hawkins Drive, 52240, Iowa City, IA, USA.

Merkel cell carcinoma (MCC) is a neuroendocrine cutaneous malignancy that may present as metastatic disease without a known primary site but, most commonly originates in the sun-exposed skin of the head, neck, and extremities. We present a 66-year-old male treated with chemo-radiation for T3N2cM0 laryngeal squamous cell carcinoma (SCCa) six years before he was diagnosed with MCC isolated to the radiated laryngopharynx. Mucosal MCC is rare and radiation-induced MCC has been hypothesized to occur in previously radiated tissue but, never before to the laryngopharynx. Read More

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http://dx.doi.org/10.1016/j.amjoto.2019.03.005DOI Listing
March 2019
1 Read

Merkel Cell Carcinoma of the Eyelid: a Review.

Surv Ophthalmol 2019 Mar 11. Epub 2019 Mar 11.

Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA; Ophthalmic Plastic Surgery Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA. Electronic address:

Merkel cell carcinoma (MCC) is a rare, aggressive tumor of both epithelial and neuroendocrine origin that carries a mortality rate of up to 40%. MCC tumors typically present as painless, expanding nodules on the sun-exposed skin areas of older, white patients. Eyelid and periocular tumors comprise approximately 2. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.03.002DOI Listing
March 2019
1 Read

Fatal squamous cell carcinoma from necrobiosis lipoidica diabeticorum in a diabetic patient.

Endocrinol Diabetes Metab Case Rep 2019 Mar 14;2019. Epub 2019 Mar 14.

Wolfson Diabetes Centre, Addenbrooke's Hospital Cambridge, Cambridge, UK.

Necrobiosis lipoidica diabeticorum (NLD) is a chronic granulomatous dermatitis generally involving the anterior aspect of the shin, that arises in 0.3-1.2% of patients with diabetes mellitus (1). Read More

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http://dx.doi.org/10.1530/EDM-19-0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432984PMC
March 2019
9 Reads

Large single cutaneous metastasis of colon adenocarcinoma mimicking a squamous cell carcinoma of the skin: A case report.

Int J Surg Case Rep 2019 7;56:96-100. Epub 2019 Mar 7.

Multidisciplinary Department of Medical and Dental Specialties, Università degli Studi della Campania "Luigi Vanvitelli", Plastic Surgery Unit, Naples, Italy.

Introduction: Metastases represent one of the most outstanding characteristics of malignant neoplasms and are relatively rare in the skin, in spite of the great extension of the cutaneous organs. Development of cutaneous metastases from colon cancer is a rare event, usually occurring in widely disseminated disease and commonly leading to a poor prognosis. As to location, cutaneous metastases often favor areas close to the primary malignancy, such as lung cancer and skin metastases on the trunk. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193010
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http://dx.doi.org/10.1016/j.ijscr.2019.02.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424055PMC
March 2019
9 Reads

Sustained complete response to erlotinib in squamous cell carcinoma of the head and neck: A case report.

World J Clin Cases 2019 Mar;7(5):616-622

Division of Medical Oncology and Hematology, Department of Medicine, Loma Linda University, Loma Linda, CA 92357, United States.

Background: Squamous cell carcinoma of head and neck (SCCHN) is the fifth most common cancer worldwide. Inhibition of epidermal growth factor receptor signaling has been shown to be a critical component of therapeutic option. Herein, we report a case of durable complete response to erlotinib. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i5.616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406195PMC
March 2019
11 Reads

Merkel cell carcinoma metastatic to cervical lymph node in a patient with rheumatoid arthritis: a case report.

Onco Targets Ther 2019 19;12:1395-1400. Epub 2019 Feb 19.

Department of Radiotherapy Oncology, Zhuji People's Hospital of Zhejiang Province, The Zhuji Affiliated Hospital of Wenzhou Medical University, Zhuji, Zhejiang 311800, China,

Merkel cell carcinoma (MCC) is a rare, aggressive skin malignancy that has a propensity for local recurrence and metastasis to the lymph nodes. In this case report, we discuss a 54-year-old female with rheumatoid arthritis (RA) who had received treatment with prednisone (15 mg/day) for symptom relief and management. The patient visited our hospital with complaints of a nodule in right preauricular area. Read More

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https://www.dovepress.com/merkel-cell-carcinoma-metastatic-t
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http://dx.doi.org/10.2147/OTT.S188403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388979PMC
February 2019
9 Reads
1.342 Impact Factor

Canine Spindle Cell Mammary Tumor: A Retrospective Study of 67 Cases.

Vet Pathol 2019 Mar 11:300985819829522. Epub 2019 Mar 11.

1 Department Animal Medicine, Surgery and Pathology, Veterinary Medicine School, Complutense University of Madrid (UCM), Madrid, Spain.

Canine spindle cell mammary tumor (CSCMT) is an infrequent canine mammary tumor (CMT) composed of spindle or fusiform cells, which represents a challenge for pathologists and clinicians. Mammary tumors submitted for histopathology from 1998 to 2013 and compatible with CSCMTs were retrospectively selected. The tumors were diagnosed based on the hematoxylin and eosin (HE)-stained section; malignant tumors were graded using a canine soft tissue sarcoma grading scheme and a canine mammary tumor grading scheme, and they were further assigned a diagnosis based on immunohistochemistry (IHC) for pancytokeratin, cytokeratin 14, p63, calponin, vimentin, Ki-67, CD31, desmin, myosin, smooth muscle actin, glial fibrillary acidic protein, and S-100. Read More

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http://dx.doi.org/10.1177/0300985819829522DOI Listing
March 2019
3 Reads

Identification of Rigosertib for the Treatment of Recessive Dystrophic Epidermolysis Bullosa-Associated Squamous Cell Carcinoma.

Clin Cancer Res 2019 Mar 7. Epub 2019 Mar 7.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

Squamous cell carcinoma (SCC) of the skin is the leading cause of death in patients with the severe generalized form of the genetic disease recessive dystrophic epidermolysis bullosa (RDEB). Although emerging data are identifying why patients suffer this fatal complication, therapies for treatment of RDEB SCC are in urgent need. We previously identified polo-like kinase 1 (PLK1) as a therapeutic target in skin SCC, including RDEB SCC. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2661DOI Listing
March 2019
1 Read

Uncommon Presentation of Metastatic Squamous Cell Carcinoma of the Skin and Treatment Challenges.

Am J Case Rep 2019 Mar 6;20:294-299. Epub 2019 Mar 6.

Department of Pathology, Brookdale University Hospital Medical Center, Brooklyn, NY, USA.

BACKGROUND Squamous cell carcinoma is one of the most common keratinocytic skin cancers, the other being basal cell carcinoma. It is the second most common skin cancer after melanoma. Cutaneous squamous cell carcinoma is mostly a localized disease. Read More

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http://dx.doi.org/10.12659/AJCR.913488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419533PMC
March 2019
4 Reads

Cabozantinib in advanced non-clear-cell renal cell carcinoma: a multicentre, retrospective, cohort study.

Lancet Oncol 2019 Apr 28;20(4):581-590. Epub 2019 Feb 28.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Electronic address:

Background: Cabozantinib is approved for patients with metastatic renal cell carcinoma on the basis of studies done in clear-cell histology. The activity of cabozantinib in patients with non-clear-cell renal cell carcinoma is poorly characterised. We sought to analyse the antitumour activity and toxicity of cabozantinib in advanced non-clear-cell renal cell carcinoma. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30907-0DOI Listing
April 2019
3 Reads

Merkel Cell Carcinoma: Therapeutic Update and Emerging Therapies.

Dermatol Ther (Heidelb) 2019 Feb 28. Epub 2019 Feb 28.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico, Naples, Italy.

Merkel cell carcinoma (MCC) is a rare but highly aggressive neuroendocrine skin cancer whose incidence has almost doubled in recent decades. Risk factors for MCC include age > 65 years, immunosuppression, sun exposure and infection by Merkel cell polyomavirus. MCC usually presents as rapidly growing, firm, red to violaceous nodule localized on the sun-exposed skin. Read More

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http://link.springer.com/10.1007/s13555-019-0288-z
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http://dx.doi.org/10.1007/s13555-019-0288-zDOI Listing
February 2019
5 Reads

B7-H3 Expression in Merkel Cell Carcinoma-Associated Endothelial Cells Correlates with Locally Aggressive Primary Tumor Features and Increased Vascular Density.

Clin Cancer Res 2019 Feb 26. Epub 2019 Feb 26.

Department of Pathology, the University of Texas MD Anderson Cancer Center, Houston, Texas.

Merkel cell carcinoma (MCC) is an aggressive cutaneous malignancy whose pathogenesis and prognosis are related to the integrity of the host immune system. Despite promising clinical responses to immune-checkpoint blockade, response and resistance remain unpredictable, underscoring a critical need to delineate novel prognostic biomarkers and/or therapeutic targets for this disease. Expression of immune-regulatory markers (PD-L2, B7-H3, B7-H4, IDO-1, ICOS, TIM3, LAG3, VISTA, and OX-40) was assessed using singlet chromogenic IHC in 10 primary MCCs. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2355DOI Listing
February 2019
6 Reads
8.722 Impact Factor

Concurrent Selective Lymph Node Radiotherapy and S-1 Plus Cisplatin for Esophageal Squamous Cell Carcinoma: A Phase II Study.

Ann Surg Oncol 2019 Feb 25. Epub 2019 Feb 25.

Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong Province, People's Republic of China.

Background: The efficacy, toxicity, and patterns of failure of esophageal squamous cell carcinoma (ESCC) treated with selective lymph node (SLN) conventional fraction radiotherapy (CFRT) and S-1 plus cisplatin (CDDP) were evaluated.

Patients And Methods: 67 Patients with clinical stage II-IVa ESCC were enrolled. The total dose of SLN CFRT was 60 Gy in 30 fractions over 6 weeks. Read More

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http://dx.doi.org/10.1245/s10434-019-07264-4DOI Listing
February 2019
2 Reads

Infrared and Raman Spectroscopic Studies of Molecular Disorders in Skin Cancer.

In Vivo 2019 Mar-Apr;33(2):567-572

Radiation Chemistry and Biospectroscopy, Chemical Engineering School, National Technical University of Athens, Athens, Greece

Aim: To investigate the molecular structural disorders of cancerous skin.

Materials And Methods: Human malignant melanoma and basal cell carcinoma biopsies were used for the investigation. Fourier transform infrared (FT-IR), Raman spectroscopy, and scanning electron microscopy were utilized. Read More

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http://dx.doi.org/10.21873/invivo.11512DOI Listing
November 2018
1 Read

Immune Checkpoint Inhibitors and Beyond: An Overview of Immune-Based Therapies in Merkel Cell Carcinoma.

Authors:
Mahtab Samimi

Am J Clin Dermatol 2019 Feb 19. Epub 2019 Feb 19.

Dermatology Department, University Hospital of Tours, Avenue de la République, 37170, Chambray-les-Tours, France.

Merkel cell carcinoma (MCC) is an aggressive skin cancer. Until 2017, patients with advanced disease were typically treated with conventional chemotherapies, with a median response duration of 3 months. Increased evidence of the role of the immune system in controlling this cancer has paved the way for immune-based therapies, with programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) inhibitors at the frontline. Read More

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http://dx.doi.org/10.1007/s40257-019-00427-9DOI Listing
February 2019
8 Reads

A case of capecitabine-induced dermatomyositis.

Indian J Pharmacol 2018 Nov-Dec;50(6):350-353

Department of Dermatology, MLN Medical College, Allahabad, Uttar Pradesh, India.

Dermatomyositis (DM) is an idiopathic, inflammatory connective tissue disorder characterized by symmetrical proximal myopathy and characteristic skin involvement. The pathogenesis of DM is widely debated; however, it is postulated to be an end result of immune-mediated cascade, triggered by multiple environmental factors in a genetically predisposed individual. In addition to underlying malignancies, many drugs have been reported to be associated with DM. Read More

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http://dx.doi.org/10.4103/ijp.IJP_356_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364339PMC
February 2019
0.679 Impact Factor

Viral genome integration of canine papillomavirus 16.

Papillomavirus Res 2019 Feb 13;7:88-96. Epub 2019 Feb 13.

Department of Pathology, Georgetown University Medical Center, Washington, DC, USA.

Papillomaviruses infect humans and animals, most often causing benign proliferations on skin or mucosal surfaces. Rarely, these infections persist and progress to cancer. In humans, this transformation most often occurs with high-risk papillomaviruses, where viral integration is a critical event in carcinogenesis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058521183012
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http://dx.doi.org/10.1016/j.pvr.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402295PMC
February 2019
4 Reads

Insight into Imiquimod Skin Permeation and Increased Delivery Using Microneedle Pre-treatment.

Eur J Pharm Biopharm 2019 Feb 13. Epub 2019 Feb 13.

Division of Advanced Materials and Healthcare Technologies, School of Pharmacy, The University of Nottingham, NG7 2RD, UK. Electronic address:

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only licensed by the FDA for superficial BCC. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.02.006DOI Listing
February 2019
4 Reads

Unusual Sites of Metastatic and Benign I 131 Uptake in Patients with Differentiated Thyroid Carcinoma.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):740-750

Department of Nuclear Medicine and Molecular Imaging, Amrita Institute of Medical Sciences, Amrita Vishwavidyapeetham, Cochin, Kerala, India.

Introduction: Differentiated thyroid carcinoma (DTC) is the most common pathological type of thyroid carcinoma, which includes papillary and follicular subtypes. DTC is usually indolent, characterized by good prognosis, and long-term survival. Total thyroidectomy is the mainstay of treatment in DTC which is followed by diagnostic whole body 131I (WBI) scan. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_70_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330860PMC
February 2019
4 Reads

Effects of thoracic epidural anesthesia/analgesia on the stress response, pain relief, hospital stay, and treatment costs of patients with esophageal carcinoma undergoing thoracic surgery: A single-center, randomized controlled trial.

Medicine (Baltimore) 2019 Feb;98(7):e14362

Department of Anesthesiology, The first affiliated hospital of Nanjing Medical University, Nanjing, 210029, China.

Background: Appropriate postoperative pain management can improve outcomes in patients with esophageal cancer (EC).

Objective: To compare different combinations of anesthesia and analgesia techniques in patients with EC undergoing open thoracotomy.

Methods: This randomized, controlled, open-label trial enrolled 100 patients with EC (aged 40-65 years; American Society of Anesthesiologists [ASA] grade I/II) receiving elective surgery at Jiangsu Province Hospital (China) between July 2016 and December 2017. Read More

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http://dx.doi.org/10.1097/MD.0000000000014362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408022PMC
February 2019
3 Reads
5.723 Impact Factor

Allyl isothiocyanate regulates lysine acetylation and methylation marks in an experimental model of malignant melanoma.

Eur J Nutr 2019 Feb 14. Epub 2019 Feb 14.

Department of Applied Sciences, Translational Biosciences Group, Northumbria University, Ellison Building, Newcastle Upon Tyne, NE1 8ST, UK.

Objective(s): Isothiocyanates (ITCs) are biologically active plant secondary metabolites capable of mediating various biological effects including modulation of the epigenome. Our aim was to characterize the effect of allyl isothiocyanate (AITC) on lysine acetylation and methylation marks as a potential epigenetic-induced anti-melanoma strategy.

Methods: Our malignant melanoma model consisted of (1) human (A375) and murine (B16-F10) malignant melanoma as well as of human; (2) brain (VMM1) and lymph node (Hs 294T) metastatic melanoma; (3) non-melanoma epidermoid carcinoma (A431) and (4) immortalized keratinocyte (HaCaT) cells subjected to AITC. Read More

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http://dx.doi.org/10.1007/s00394-019-01925-6DOI Listing
February 2019
4 Reads

Multiple cutaneous metastasis of synchronous urothelial carcinoma of the bladder and the renal pelvis: a case report.

J Med Case Rep 2019 Feb 14;13(1):34. Epub 2019 Feb 14.

Surgical Oncology Department, Institute Salah Azaiez de Cancer, Tunis, Tunisia.

Introduction: Cutaneous metastatic disease arising from urinary tract carcinoma is rare and associated with a poor prognosis. We report a case of metastatic disease occurring in a patient treated for synchronous urothelial tumor of the bladder and left renal pelvis.

Case Presentation: A 61-year-old Caucasian man was treated for a synchronous urothelial tumor of the bladder and left renal pelvis. Read More

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http://dx.doi.org/10.1186/s13256-019-1997-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375173PMC
February 2019
1 Read

Diagnosis and Management of Basal Cell Carcinoma.

Authors:
Keiji Tanese

Curr Treat Options Oncol 2019 Feb 11;20(2):13. Epub 2019 Feb 11.

Department of Dermatology, Keio University School of Medicine, Shinanomachi 35, Shinjuku, Tokyo, 160-8582, Japan.

Opinion Statement: Basal cell carcinomas (BCCs) are common skin cancers that tend to appear on sun-exposed skin. Pathobiologically, activation of the Hedgehog signaling pathway characterizes the majority of cases. In general, BCCs are slow-growing and rarely metastasize. Read More

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http://link.springer.com/10.1007/s11864-019-0610-0
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http://dx.doi.org/10.1007/s11864-019-0610-0DOI Listing
February 2019
10 Reads

Recurrent Metastatic Eccrine Porocarcinoma: A Case Report and Review of the Literature.

Am J Case Rep 2019 Feb 11;20:179-183. Epub 2019 Feb 11.

Division of Hematology and Oncology, Bronx Care Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, NY, USA.

BACKGROUND Eccrine porocarcinoma, or malignant eccrine poroma, is a rare primary skin tumor that develops in the sixth and seventh decades of life, and can present as a painless and solitary nodule. Histopathology is required to confirm the diagnosis. A rare case is presented of metastatic eccrine porocarcinoma, occurring four years after surgical excision of the primary scalp tumor, and includes a review of the literature. Read More

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http://dx.doi.org/10.12659/AJCR.913440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380207PMC
February 2019
3 Reads

Follicular thyroid carcinoma metastatic to skin: a small papule and a big diagnostic change.

An Bras Dermatol 2019 Jan-Feb;94(1):76-78

Department of Pathology, Laboratório Bacchi, Botucatu (SP), Brazil.

Cutaneous metastases are uncommon in daily practice, although very important, since they may be the first manifestation of an undiscovered primary neoplasm or the first indication of recurrence. Cutaneous metastases from the breast are the most frequent in women and cutaneous metastases from the lung are the most frequent in men. Thyroid carcinoma, despite representing the most frequent endocrine neoplasm, is considered a rare neoplasm, corresponding to 1% of malignant neoplasms diagnosed. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20198299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360978PMC
February 2019
13 Reads

Hand-Foot Syndrome and Progression-Free Survival in Patients Treated with Sunitinib for Metastatic Clear Cell Renal Cell Carcinoma.

Adv Exp Med Biol 2019;1133:35-40

Department of Uro-Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.

Patients with metastatic clear cell renal cell carcinoma (mRCC) typically receive systemic treatment with tyrosine kinase inhibitors (TKI). Side effects include the hand-foot syndrome (HFS), tiredness, nausea, decreased appetite, diarrhea, myelosuppression, and hypertension. This study seeks to define the relationship between the incidence of HFS after the first cycle of treatment with sunitinib as the first-line treatment for mRCC (50 mg/day, 6-week schedule: 4 weeks on and 2 weeks off) and progression-free survival. Read More

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http://link.springer.com/10.1007/5584_2018_328
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http://dx.doi.org/10.1007/5584_2018_328DOI Listing
January 2019
9 Reads