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    8423 results match your criteria Metastatic Carcinoma of the Skin

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    Impact of baseline characteristics on outcomes of advanced HCC patients treated with sorafenib: a secondary analysis of a phase III study.
    J Cancer Res Clin Oncol 2018 Feb 17. Epub 2018 Feb 17.
    Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
    Background: The current study aims to investigate the impact of baseline characteristics on the outcomes of sorafenib-treated advanced Hepatocellular carcinoma (HCC) patients in the setting of a clinical trial.

    Methods: This is a secondary analysis of the comparator arm (sorafenib arm) of the NCT00699374 study which is a phase III multicenter study conducted between 2008 and 2010. The univariate probability of overall and progression-free survival was assessed among different patient subsets through Kaplan-Meier analysis and log-rank testing. Read More

    A phase I and pharmacokinetic study of taladegib, a Smoothened inhibitor, in Japanese patients with advanced solid tumors.
    Invest New Drugs 2018 Feb 17. Epub 2018 Feb 17.
    Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
    Background This phase I dose-escalation study investigated the safety of the Smoothened inhibitor taladegib in Japanese patients with advanced solid tumors. Methods Patients received taladegib orally once daily for 28-day cycles, using a 3 + 3 dose-escalation method. The primary objective was the safety and tolerability of taladegib at doses up to the global recommended dose (400 mg). Read More

    Parotid metastasis of renal cell carcinoma, mimicking primary clear cell oncocytoma: report of a case and brief review of the literature.
    Pathologica 2017 Dec;109(4):384-388
    Pathology Unit, ASST Valle Olona, Busto Arsizio, Italy.
    Malignancies of the parotid gland are relatively uncommon, accounting for only 3-6% of all head and neck cancers. Most of them are primary neoplasms, metastases are uncommon. Renal cell carcinoma (RCC) represents 3% of adult malignancies, the clear cell type comprises up to 70% of all RCC. Read More

    Cabozantinib in Patients with Advanced Merkel Cell Carcinoma.
    Oncologist 2018 Feb 14. Epub 2018 Feb 14.
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
    Background: This study sought to determine the efficacy and safety profile of cabozantinib in patients with advanced Merkel cell carcinoma (MCC).

    Experimental Design: This prospective, phase II, single-institution trial enrolled patients with platinum-failure, recurrent/metastatic MCC to receive cabozantinib 60 mg orally daily until disease progression, withdrawal from study, or severe toxicity. The primary endpoint was disease control rate. Read More

    Eyelashes Trichomegaly: An Unusual Side Effect of Gefitinib Therapy.
    Int J Trichology 2018 Jan-Feb;10(1):44-46
    Department of Obstetrics and Gynecology, Baba Saheb Ambedkar Medical College and Hospital, New Delhi, India.
    Evolution of targeted therapy has changed the spectrum of treatment in oncology since the past two decades as lots of newer agents are being added to the pharmacologic armamentarium of cancer therapy. Epidermal growth factor receptor inhibitors form one such advancing field with many newer agents being investigated and they are used in wide variety of malignancies such as head and neck cancer, lung cancer, and even gastrointestinal malignancies such as pancreatic cancer. Various troublesome side effects of these agents include diarrhea, severe fatigability, severe skin rashes, and deranged liver function tests which may require treatment interruption or dose reduction resulting in decreased response to treatment. Read More

    Ulcerated Basal Cell Carcinomas Masquerading as Venous Leg Ulcers.
    Adv Skin Wound Care 2018 Mar;31(3):130-134
    Catherine N. Tchanque-Fossuo, MD, MS, is a Clinical Wound Fellow, at both the Department of Dermatology, University of California Davis, Sacramento, and the Dermatology Service, VA Northern California Health Care Systems, Mather, California. Jillian W. Millsop, MD, MS, is a Dermatology Resident, Department of Dermatology, University of California Davis, Sacramento, California. Mary Ann Johnson, MD, MS, is a Dermatologist, Mercy Medical Group-Dignity Health, El Dorado Hills, California. Sara E. Dahle, DPM, MPH, is Chief, Podiatry Section, Department of Surgery, VA Northern California Health Care Systems, Mather, and Assistant Professor, Department of Dermatology, University of California Davis, Sacramento, California. R. Rivkah Isseroff, MD, is Chief, Dermatology Service, VA Northern California Health Care Systems, Mather, and Professor, Department of Dermatology, University of California Davis, Sacramento, California. The authors have disclosed they have no financial relationships related to this article. Submitted January 15, 2017; accepted in revised form October 27, 2017.
    Background: Nonmelanoma skin cancers rarely arise from venous leg ulcers (VLUs). Although basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer, its association with lower-extremity ulcers is not as frequently reported as other malignancies.

    Objective: To report a case series of biopsy-proven BCC from lower-extremity ulcers of patients who presented at a multispecialty wound clinic. Read More

    Therapy-associated myelodysplastic syndrome with monosomy 7 arising in a Muir-Torre Syndrome patient carryingmutation.
    Mol Clin Oncol 2018 Feb 8;8(2):306-309. Epub 2017 Dec 8.
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
    Muir-Torre Syndrome (MTS) is a rare hereditary autosomal dominant cancer syndrome and is linked to hereditary non-polyposis colorectal carcinoma (Lynch Syndrome). Individuals develop various skin neoplasms in addition to colorectal, endometrial and upper gastrointestinal malignancies. Therapy-associated myelodysplastic syndrome (T-MDS) is an aggressive hematologic malignancy and is considered a pre-leukemic phase. Read More

    A randomized, multi-national, non-inferiority, phase III trial to evaluate the safety and efficacy of BF-200 ALA gel versus MAL cream in the treatment of non-aggressive basal cell carcinoma with photodynamic therapy (PDT).
    Br J Dermatol 2018 Feb 12. Epub 2018 Feb 12.
    Department of Dermatology and Allergology, Vest Clinic, Recklinghausen, Germany.
    Background: Basal cell carcinoma (BCC) represents the most common non-melanoma skin cancer worldwide affecting mainly adult, fair-skinned individuals. The WHO distinguishes aggressive and non-aggressive forms of which prototypical variants of the latter are primary nodular and superficial BCC.

    Objectives: To demonstrate non-inferiority of BF-200 ALA (a nanoemulsion gel containing 5-aminolaevulinic acid) compared to MAL (a cream containing methyl-aminolevulinate) in the treatment of non-aggressive BCC with photodynamic therapy (PDT). Read More

    GATA-3 staining in primary cutaneous apocrine cribriform carcinoma: usefulness To differentiate it from breast cancer metastasis.
    J Cutan Pathol 2018 Feb 12. Epub 2018 Feb 12.
    Dermatopathologie Friedrichshafen, Friedrichshafen, Germany.
    Background: Primary cutaneous apocrine cribriform carcinoma (PCACC) is a rare tumor, clinically appearing as a solitary nodule, mostly involving extremities of females and this lesion usually raise a differential diagnosis with metastatic cribriform carcinomas, especially breast cancer.

    Design: To study GATA3 expression in a series of 14 primary cutaneous cribriform carcinomas and to test this immunostaining usefulness to differentiate this tumor from metastatic breast cancer.

    Results: No primary cutaneous apocrine cribriform carcinoma express GATA3. Read More

    Cutaneous Metastases from Salivary Duct Carcinoma of the Submandibular Gland.
    Case Rep Dermatol 2017 Sep-Dec;9(3):254-258. Epub 2017 Dec 5.
    Department of Plastic and Breast Surgery, Zealand University Hospital - Roskilde, Roskilde, Denmark.
    Salivary duct carcinoma is a rare and highly aggressive malignant neoplasm that frequently metastasises to other organs, but cutaneous metastasis is uncommon. There are only 6 cases reported in the literature with metastases to the skin and in all cases the tumour originates from the parotid gland. We present a case of skin metastases from the submandibular gland that was mistaken for basal cell carcinoma. Read More

    Phase II trial of combination treatment with paclitaxel, carboplatin and cetuximab (PCE) as first-line treatment in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (CSPOR-HN02).
    Ann Oncol 2018 Feb 2. Epub 2018 Feb 2.
    Department of Biostatistics, Yokohama City University School of Medicine, Yokohama, Japan.
    Background: The standard of care for first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) is combination treatment with platinum, 5-FU and cetuximab (PFE). However, this regimen requires hospitalization to ensure proper hydration and continuous infusion of 5-FU, and causes severe nausea and anorexia. We evaluated the efficacy and safety of paclitaxel, carboplatin and cetuximab (PCE) as first-line treatment in patients with R/M SCCHN. Read More

    Emerging trends in the treatment of advanced basal cell carcinoma.
    Cancer Treat Rev 2017 Dec 14;64:1-10. Epub 2017 Dec 14.
    Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
    Basal cell carcinoma (BCC) is the most commonly diagnosed skin cancer worldwide. In most patients, BCC can be effectively treated with standard surgical excision, Mohs micrographic surgery, curettage and electrodessication, radiotherapy, and/or superficial field therapies (including 5-fluorouracil, imiquimod, and photodynamic therapy); however, a minority of patients develop advanced BCC, for which treatment can be challenging and outcomes are poorer. Advanced BCC encompasses a heterogeneous assortment of cases, including metastatic BCC as well as locally advanced BCC (for which no formal definition exists but which generally includes large, deep, aggressive, or recurrent tumors). Read More

    [Breast Cancer Occurring in the Axillary Area - A Case Report].
    Gan To Kagaku Ryoho 2017 Nov;44(12):1635-1637
    Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.
    A 50-year-old woman aware a lump in the right axillary area 5 years ago.She noticed that the lump gradually became bigger, accompanied by redness and gathering of the skin; therefore, she consulted a dermatologist.On receiving the result of skin biopsy, she was referred for a suspected metastatic lesion from breast cancer. Read More

    [A Case of Stage IV Breast Cancer with Extensive Metastasis Successfully Treated with S-1 plus Anastrozole Therapy].
    Gan To Kagaku Ryoho 2017 Nov;44(12):1479-1481
    Mugitani Clinic.
    We report the case of a patient in which S-1 plus anastrozole was administered as first-line chemotherapy for Stage IV breast cancer with skin invasion, multiple lymph node metastasis, and lymphangitis carcinomatosis. A 77-year-old woman had a mass destroyed immediately outside the axilla with dry coughs. An 11mm unpalpable mass in the right breast and an axillary mass were confirmed to be scirrhous carcinoma(Luminal type B), respectively, by core needle biopsy. Read More

    [Neoadjuvant Chemoradiotherapy for Locally Advanced Carcinoma Associated with Anal Fistula].
    Gan To Kagaku Ryoho 2017 Nov;44(12):1437-1439
    Dept. of Surgery, Ohtanishinouchi Hospital.
    The patient was a 59-year-old man. He was admitted to our hospital because of increasing anal pain with induration of the perianal region. There were large secondary orifices with mucous discharge on the left side of the perineal resion and buttock. Read More

    [A Case Report of Adenocarcinoma with Pagetoid Growth(Secondary Paget's Disease)of the Anal Canal].
    Gan To Kagaku Ryoho 2017 Nov;44(12):1332-1334
    Division of Digestive Surgery, Dept. of Surgery, Kyoto Prefectural University of Medicine.
    Differentiating primary Paget's disease from secondary Paget's disease, which is also known as Pagetoid growth of other cancers, in the perianal region is difficult. Given that the treatment strategies of both disease are significantly different, diagnosis of such conditions should be performed with caution. We report a case of secondary Paget's disease. Read More

    Different Toxicity of Cetuximab and Panitumumab in Metastatic Colorectal Cancer Treatment: A Systematic Review and Meta-Analysis.
    Oncology 2018 Jan 23. Epub 2018 Jan 23.
    Oncology Unit, Oncology Department, ASST Ospedale di Cremona, Cremona, Italy.
    Background: Over the last few years only one large randomized phase III study has tried to prospectively assess the safety of cetuximab and panitumumab in a head-to-head comparison. Despite the similar overall toxicity profile, cetuximab and panitumumab retain peculiar safety characteristics that deserve to be deeply investigated.

    Methods: We conducted a systematic review for randomized trials in PubMed, the Cochrane Central Register of Controlled Trials, SCOPUS, Web of Science, and EMBASE using the terms ("cetuximab" or "panitumumab") AND ("colorectal cancer" OR "colorectal carcinoma"). Read More

    Defect Reconstruction of the Nose After Surgery for Nonmelanoma Skin Cancer: Our Clinical Experience.
    Turk Arch Otorhinolaryngol 2017 Sep 1;55(3):111-118. Epub 2017 Sep 1.
    Department of Otorhinolaryngology, Ege University School of Medicine, İzmir, Turkey.
    Objective: This study aimed to investigate reconstruction methods according to nasal subunits in patients who were surgically treated with diagnosis of non-melanoma skin cancer of the nose.

    Methods: All patients were retrospectively investigated. This study was conducted between April 2004 and December 2010; 180 patients who were surgically treated with diagnoses of skin basal cell carcinoma, squamous cell carcinoma, cancer of skin appendages, and precancerous lesions and 194 lesions were included. Read More

    Pembrolizumab for recurrent/metastatic head and neck squamous cell carcinoma in an Asian population.
    Medicine (Baltimore) 2017 Dec;96(52):e9519
    Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital.
    Head and neck squamous cell carcinoma (HNSCC) has a high prevalence and is a major cause of cancer deaths in Taiwan. However, there is still no effective salvage therapy that prolongs the life expectancy of patients with recurrent/metastatic (R/M) HNSCC. Immune checkpoint therapy that targets the programmed cell death protein 1 (PD-1) may provide clinical benefit for these patients. Read More

    Multicenter retrospective study of cetuximab plus platinum-based chemotherapy for recurrent or metastatic oral squamous cell carcinoma.
    Cancer Chemother Pharmacol 2018 Jan 30. Epub 2018 Jan 30.
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
    Purpose: The purpose of this study was to assess the efficacy and safety of cetuximab plus platinum-based chemotherapy for patients specifically diagnosed with recurrent or metastatic oral squamous cell carcinoma (OSCC).

    Methods: We conducted a multicenter retrospective observational study of patients who underwent first-line cetuximab plus platinum-based chemotherapy between December 2012 and June 2015. 65 patients received weekly cetuximab (week 1, 400 mg/m; subsequent weeks, 250 mg/m) plus a maximum of six 3-weekly cycles of cisplatin (80 or 100 mg/m, day 1) or carboplatin (at an area under the curve of 5 mg/mL/min as a 1-h intravenous infusion on day 1) and 5-fluorouracil (800 or 1000 mg/m/day, days 1-4). Read More

    Skin CanceR Brachytherapy vs External beam radiation therapy (SCRiBE) meta-analysis.
    Radiother Oncol 2018 Jan 19. Epub 2018 Jan 19.
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, USA.
    Background And Purpose: To compare cosmesis and local recurrence (LR) of definitive external beam radiation therapy (EBRT) vs brachytherapy (BT) for indolent basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin.

    Materials And Methods: Studies including patients with T1-2 N0 SCCs/BCCs treated with definitive EBRT/BT and ≥10 months follow-up were analyzed. The primary endpoint was post-treatment cosmesis, categorized as "good," "fair," or "poor. Read More

    Nihon Hinyokika Gakkai Zasshi 2017 ;108(1):41-44
    Department of Urology, National Hospital Organization Higashi-Hiroshima Medical Center.
    The patient was a 71-year-old man referred to our department because of asymptomatic gross hematuria. Detailed examination led to a diagnosis of bilateral ureteral cancer and prostate cancer. Total nephroureterectomy was performed for bilateral ureteral cancers on separate occasions, while prostate cancer was managed with hormone therapy. Read More

    Primary Cutaneous Mucinous Carcinoma with Extramammary Paget's Disease: Eccrine or Apocrine?
    J Pathol Transl Med 2018 Jan 25. Epub 2018 Jan 25.
    Department of Pathology, Kosin University Gospel Hospital, Busan, Korea.
    Primary cutaneous mucinous carcinoma (PCMC) is an uncommon tumor of the sweat gland origin. The occurrence of PCMC is mostly in middle-aged and older patients, with a slight male predominance. Most cases of PCMC arise on the head, with a preference for eyelids. Read More

    [A Case of Port Site Recurrence of Gallbladder Carcinoma after Laparoscopic Cholecystectomy].
    Gan To Kagaku Ryoho 2018 Jan;45(1):82-84
    Dept. of Surgery, Kansai Medical University.
    The patient was a 76-year-old man who underwent laparoscopic cholecystectomy with a diagnosis of cholecystolithiasis. Since the definite diagnosis of gallbladder carcinoma was made after the operation, he underwent additional resection. Four years later, he revisited the hospital complaining of painful swelling of the port site of his epigastrium. Read More

    Head and neck squamous cell carcinoma of unknown primary: Outcomes of a pre-defined institutional treatment policy in a region with a high prevalence of skin cancer.
    Oral Oncol 2018 Feb 20;77:43-48. Epub 2017 Dec 20.
    Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, Queensland, Australia; The University of Queensland, Queensland, Australia.
    Objectives: To determine the rate of subsequent primary site failure in patients with head and neck squamous cell carcinoma of unknown primary (UKP HNSCC) in a region with a high prevalence of cutaneous squamous cell carcinoma, according to a pre-determined institutional policy. Secondary aims included regional and distant control, and overall survival.

    Material And Methods: Patients presenting between April 2005 and June 2016 to the Princess Alexandra Hospital Head and Neck Multidisciplinary Meeting with UKP HNSCC from either presumed mucosal or cutaneous sites treated with curative intent were eligible. Read More

    Unusual skin mass (primary cutaneous mucinous carcinoma).
    BMJ Case Rep 2018 Jan 18;2018. Epub 2018 Jan 18.
    Department of Pathology, Army Medical College, Rawalpindi, Pakistan.
    Primary mucinous carcinoma of the skin is a rare malignant tumour of sweat gland origin. Diagnostic concerns include its deceptively benign appearance in some cases and the difficulty in differentiating it from secondary mucinous carcinoma of skin metastasising from a primary source elsewhere. A case of a 75-year-old man is reported who presented with a slowly growing painless mass near the lateral canthus of the right eye for about 2 years. Read More

    Updated efficacy of avelumab in patients with previously treated metastatic Merkel cell carcinoma after ≥1 year of follow-up: JAVELIN Merkel 200, a phase 2 clinical trial.
    J Immunother Cancer 2018 Jan 19;6(1). Epub 2018 Jan 19.
    University of Washington Medical Center at South Lake Union, Seattle, WA, USA.
    Background: Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer associated with poor survival outcomes in patients with distant metastatic disease (mMCC). In an initial analysis from JAVELIN Merkel 200, a phase 2, prospective, open-label, single-arm trial in mMCC, avelumab-a human anti-programmed death-ligand 1 (PD-L1) monoclonal antibody-showed promising efficacy and a safety profile that was generally manageable and tolerable. Here, we report the efficacy of avelumab after ≥1 year of follow-up in patients with distant mMCC that had progressed following prior chemotherapy for metastatic disease. Read More

    Comparison of the diagnostic performances of ultrasonography, CT and fine needle aspiration cytology for the prediction of lymph node metastasis in patients with lymph node dissection of papillary thyroid carcinoma: A retrospective cohort study.
    Int J Surg 2018 Jan 11;51:145-150. Epub 2018 Jan 11.
    Institution: Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, 06273, Seoul, Republic of Korea. Electronic address:
    Purpose: To evaluate the diagnostic performances of ultrasonographic (US) findings, computed tomography (CT) findings and fine needle aspiration cytology (FNAC) for the prediction of cervical lymph node (LN) metastases of papillary thyroid carcinoma (PTC) to determine which LN should be dissected.

    Methods: 376 LNs in 302 patients who underwent both US-guided skin surface LN markings and CT before LN dissection were analyzed retrospectively. Indications for LN dissection were suspicious US findings of LN metastases (n = 300), suspicious CT findings (n = 67) or surgeon's request (n = 9). Read More

    Nivolumab for recurrent cutaneous squamous cell carcinoma: three cases.
    Eur J Dermatol 2018 Jan 16. Epub 2018 Jan 16.
    Division of Medical Oncology.
    Programmed cell death ligand 1 (PD-L1) is frequently expressed in cutaneous squamous cell cancer (CSCC) and preliminary data from an ongoing clinical trial suggest that programmed death receptor 1 (PD-1) checkpoint inhibitors may be useful to treat patients with metastatic non-melanoma skin cancer. To report a series of three patients with advanced CSCC treated with nivolumab, showing that commercially available PD-1 checkpoint inhibitors may be useful in non-melanoma skin cancer patients without access to a clinical trial. All patients had previous chemotherapy. Read More

    [Initially undetected de novo psoriasis triggered by nivolumab for metastatic base of the tongue carcinoma].
    Hautarzt 2018 Jan 12. Epub 2018 Jan 12.
    Klinik für Hautkrankheiten und Allergologie, HELIOS Vogtland-Klinikum Plauen GmbH, Postfach 100153, 08505, Plauen, Deutschland.
    Nivolumab is a monoclonal antibody that binds to the PD-1 receptor on T cells and inhibits the interaction with the PD-L1 and PD-L2 ligands on cancer cells. Thus, nivolumab has immunostimulatory properties. The known side effects of this therapy include fatigue, skin rash, dysfunction of the thyroid gland and colitis, which are explained by the immunoregulatory mechanisms of the drug. Read More

    A comparison ofF-FDG PET/CT findings in HIV positive compared to HIV negative patients with recurrent cervical cancer.
    Hell J Nucl Med 2017 Sep-Dec;20 Suppl:71-79
    Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Private Bag X169, Pretoria, 0001, South Africa.
    Objective: HIV-positive women with cervical cancer have higher recurrence and death rates with shorter time to recurrence and death compared with HIV-negative subjects. The objective of this study was to compare the recurrence patterns in HIV-positive women with invasive cervical cancer to their HIV-negative counterparts usingF-FDG PET/CT.

    Subjects And Methods: We evaluated 40 HIV- seropositive and 79 HIV-seronegative patients with recurrent cervical carcinoma usingF-FDG PET/CT. Read More

    Patient-reported symptoms and stepwise symptom management in patients on epidermal growth factor inhibitors: A retrospective, descriptive cohort study.
    Eur J Cancer Care (Engl) 2018 Jan 4. Epub 2018 Jan 4.
    Department of Primary Care, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
    Adverse events (AEs) of epidermal growth factor inhibitors (EGFRi) influence well-being with a risk to dose modifications (DMs). Hereby, clinical benefit of treatment might be affected. This retrospective cohort study was set up to gain insight into the suitability and added value of a patient-reported outcome measurement tool (PROM), together with a stepwise intervention management plan for EGFRi-related AEs in daily practice. Read More

    Never too old to regenerate? Wound induced hair follicle neogenesis after secondary intention healing in a geriatric patient?
    J Tissue Viability 2018 Jan 4. Epub 2018 Jan 4.
    Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
    Wound healing is a natural process to restore the structure and function of injured or diseased tissues. Repair of a skin wound usually leads to a scar while regeneration implies fully recovery of function and structure of the damaged tissue. Adult skin wound usually heals with scar while fetal skin heals scarless. Read More

    Pancreatic panniculitis: the "bright" side of the moon in solid cancer patients.
    BMC Gastroenterol 2018 Jan 4;18(1). Epub 2018 Jan 4.
    Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, I.R.C.C.S. Fondazione Cà Granda, Ospedale Maggiore Policlinico, via Pace 9, 20122, Milan, Italy.
    Background: Pancreatic panniculitis is a rare complication of pancreas disorders occurring in 0.3-3% of patients, most often accompanied by the pancreatic acinar carcinoma. It presents multiple, painful, deep, ill-defined, red-brown, migratory nodules and plaques of hard elastic consistency; often ulcerated and typically located on the lower proximal and distal extremities. Read More

    Metastatic Basal Cell Carcinoma: A Rare Manifestation of a Common Disease.
    Case Rep Med 2017 27;2017:8929745. Epub 2017 Nov 27.
    Department of Pathological Anatomy, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.
    Introduction: Basal cell carcinoma (BCC) is considered the most common malignancy in Caucasians. It constituted about 80% of all nonmelanoma skin tumors and, despite its high prevalence, is an extremely rare occurrence of metastases, with incidence rates varying from 0.0028% to 0. Read More

    A 48-Year-Old Male with Cutaneous Metastases of NUT Midline Carcinoma Misdiagnosed as Herpes Zoster.
    Case Rep Oncol 2017 Sep-Dec;10(3):987-991. Epub 2017 Nov 6.
    Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    NUT (nuclear protein of the testis) midline carcinoma (NMC) is a rare, poorly differentiated neoplasm with dismal prognosis. Though NMC are often metastatic by the time of presentation, cutaneous metastases have not been well described in the literature. We report a case of NMC in a patient who presented with grouped well-demarcated tender non-ulcerated erythematous nodules on the right mid-back. Read More

    A Case of Metastatic Basal Cell Carcinoma Treated with Cisplatin and Adriamycin.
    J Nippon Med Sch 2017 ;84(6):286-290
    Department of Dermatology, Nippon Medical School.
    A 72-year-old man was referred to our hospital for treatment of an ulcer that had been growing on his back for 10 years. Physical examination showed an ulcerated tumor from the neck to the back and swollen cervical lymph nodes. The tumor size was 12×9 cm. Read More

    Efficacy of anti-PD-1 on skin carcinomas and melanoma metastases in an Xeroderma Pigmentosum patient.
    Br J Dermatol 2017 Dec 23. Epub 2017 Dec 23.
    Dermatology, Paul Sabatier-Toulouse III University, Institut Universitaire du Cancer de Toulouse and Larrey Hospital, Toulouse, France.
    Xeroderma pigmentosum is an orphan disease of poor prognosis. We report one case of parallel efficacy with anti-PD-1 antibody on both melanoma and skin carcinoma in a xeroderma pigmentosum patient. A 17-year old patient presented with metastatic melanoma and multiple non melanoma skin cancers. Read More

    Cutaneous metastases in a patient with no previous diagnosis of cancer: diagnostic challenge.
    An Bras Dermatol 2017 ;92(5 Suppl 1):47-49
    Dr. Günter Hans Department of Dermatology, at Hospital Universitário da Universidade Federal de Mato Grosso do Sul (NHU-UFMS) - Campo Grande (MS), Brazil.
    On rare occasions, skin lesions are the first local of metastatic manifestation of internal malignancies. In case of no previous diagnosis of these tumors, the approach of suspicious skin lesions becomes a challenge, especially in differentiating cutaneous metastases and adnexal primary neoplasms. Currently, besides epidemiologic, dermoscopic and histopathologic aspects, the evaluation also integrates immunohistochemical exams and cell markers such as p40 and p63, highly specific for skin metastases. Read More

    Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers.
    Skin Pharmacol Physiol 2017 Dec 21;31(2):59-73. Epub 2017 Dec 21.
    Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Coimbra, Portugal.
    Neoplastic skin lesions are multifocal, diffuse skin infiltrations of particular relevance in the differential diagnosis of ulcerative, nodular, or crusting skin lesions. Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and also actinic keratosis (AK), are the most common malignant tumors in humans. BCCs do not proliferate rapidly and most of the times do not metastasize, while SCCs are more infiltrative, metastatic, and destructive. Read More

    Histology of Non-Melanoma Skin Cancers: An Update.
    Biomedicines 2017 Dec 20;5(4). Epub 2017 Dec 20.
    Department of Dermatology, Dipartimento di Medicina Interna e Specialità Mediche, La Sapienza University of Rome, 00161 Rome, Italy.
    Non-melanoma skin cancer (NMSC) is the most frequently diagnosed cancer in humans. Several different non-melanoma skin cancers have been reported in the literature, with several histologic variants that frequently cause important differential diagnoses with other cutaneous tumors basal cell carcinoma (BCC) is the most common malignant skin tumor, with different histologic variants that are associated with a greater or less aggressive behavior and that usually may be confused with other primitive skin tumors. Actinic keratosis, Bowen's disease, keratoacanthoma, and invasive squamous cell carcinoma (SCC) correspond to the other line of NMSC, that may have only local tumoral behavior, easy to treat and with local management (as in the case of actinic keratosis (AK), Bowen's disease, and keratoacanthoma) or a more aggressive behavior with a potential metastatic spread, as in case of invasive SCC. Read More

    The Most Recent Oncologic Emergency: What Emergency Physicians Need to Know About the Potential Complications of Immune Checkpoint Inhibitors.
    Cureus 2017 Oct 13;9(10):e1774. Epub 2017 Oct 13.
    Emergency Medicine, University of Calgary.
    Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte associated protein 4 (CTLA-4) and programmable cell death protein 1 (PD-1)/PD-L1 have shown antitumor activity in cancers such as melanoma, non-small cell lung cancer, renal cell carcinoma, and urothelial cancer. Certain checkpoint inhibitors have been approved for use in Canada, and are becoming a mainstay in the treatment of melanoma and other malignancies. These drugs have a unique side effect profile and are known to cause immune-related adverse events (irAEs). Read More

    Critical Appraisal of the Risk of Secondary Cancer Induction From Breast Radiation Therapy With Volumetric Modulated Arc Therapy Relative to 3D Conformal Therapy.
    Int J Radiat Oncol Biol Phys 2018 Mar 31;100(3):785-793. Epub 2017 Oct 31.
    Radiotherapy and Radiosurgery Department, Humanitas Research Hospital and Cancer Center, Milan-Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Milan-Rozzano, Italy.
    Purpose: To evaluate the excess absolute risk (EAR) comparing volumetric modulated arc therapy (VMAT) and 3-dimensional (3D) conformal radiation therapy (CRT) in breast cancer radiation therapy treatment.

    Methods And Materials: Two VMAT arrangements (VMAT_tang and VMAT_full, i.e. Read More

    [What's new in oncodermatology?]
    Ann Dermatol Venereol 2017 Dec;144 Suppl 4:IVS40-IVS46
    AP-HP dermatologie, INSERM U976, université Paris 7-Diderot, hôpital Saint-Louis, Paris, France. Electronic address:
    This 'What's new in oncodermatology?' addresses the developments in 2017 on the epidemiology and management of skin cancers. We observe a constant increase in carcinomas, risk factors for squamous cell carcinoma, especially in transplant recipients where skin cancer mortality is important. Among epidemiological developments in melanoma are increased mortality despite screening, occupational exposure to UV, second melanoma and higher risk after carcinoma. Read More

    Merkel Cell Carcinoma Patients Presenting Without a Primary Lesion Have Elevated Markers of Immunity, Higher Tumor Mutation Burden, and Improved Survival.
    Clin Cancer Res 2018 Feb 15;24(4):963-971. Epub 2017 Dec 15.
    Department of Medicine (Dermatology), University of Washington, Seattle, Washington.
    Patients presenting with nodal Merkel cell carcinoma without an identifiable (unknown) primary lesion (MCC-UP) are nearly twice as likely to survive compared with similarly staged patients with known primary lesions (MCC-KP). The basis of this previously reported finding is unclear.Survival analyses and markers of immunity were evaluated in 123 patients with advanced MCC. Read More

    Two independent incidences of skin metastases in the umbilicus and abdominal wall in ovarian serous adenocarcinoma: A case report and review of the literature.
    Medicine (Baltimore) 2017 Dec;96(49):e9118
    aDepartment of Obstetrics and Gynecology, Qilu HospitalbQilu Medical School, Shandong UniversitycDepartment of Medicine, University of Ji'nandDepartment of Radiology, Qilu Hospital, Shandong University, Ji'nan, Shandong, PR China.
    Rationale: Advanced ovarian cancer is usually associated with intra-abdominal metastases and while it commonly spreads directly to the omentum, intestine, liver, or other organs, it can also metastasize through the lymphatic channels and the hematogenous pathway. With an increasing number of invasive operations being performed with chemoradiotherapy, the incidence of extra-abdominal metastases has risen. Nevertheless, ovarian cancer with skin metastases is quite rare. Read More

    Evaluation of the National Swiss Skin Cancer Screening Campaign 2013: Do We Do the Right Thing?
    Dermatology 2017 Dec 14. Epub 2017 Dec 14.
    Department of Dermatology, University of Zurich, Zurich, Switzerland.
    Background: Skin cancer prevention and screening programs are performed in many countries. Their benefit is discussed controversially.

    Objective: Our aim is to evaluate the Skin Cancer Screening Program 2013 in Switzerland by following up screenees upon interventions. Read More

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