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    7982 results match your criteria Metastatic Carcinoma of the Skin

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    Secondary Cutaneous Amyloidosis in a Patient with Mycosis Fungoides.
    Ann Dermatol 2017 Feb 3;29(1):79-82. Epub 2017 Feb 3.
    Department of Dermatology, Dankook University Medical College, Cheonan, Korea.
    Secondary cutaneous amyloidosis refers to clinically unapparent amyloid deposits within the skin in association with a pre-existing skin condition or skin tumors, such as basal cell carcinoma, porokeratosis, solar elastosis, Bowen's disease, and mycosis fungoides. A 70-year-old woman presented with a 6-month history of asymptomatic multiple yellowish plaques on both legs. She had been diagnosed with mycosis fungoides 7 years ago and was treated with psoralen and ultraviolet A radiation (PUVA) therapy, narrow-band ultraviolet B (UVB) therapy, and acitretin for 5 years. Read More

    A Rare Case of CK20/CK7 Double Negative Merkel Cell Carcinoma.
    Am J Dermatopathol 2017 Mar;39(3):208-211
    *Department of Pathology, University of California Los Angeles, Los Angeles, CA; †Southern California Permanente Medical Group, Department of Dermatology, Sunset Medical Center, Los Angeles, CA; and ‡Department of Pathology, Kaiser Southern California Permanente Medical Group, Los Angeles, CA.
    The authors present a case of Merkel cell carcinoma (MCC) with unique immunohistochemical staining characteristics. A 57-year-old woman presented with a firm 0.3 cm tan papule on her left nasal-labial fold that was reportedly increasing in size and bleeding. Read More

    Multiple nonsyndromic acquired basal cell carcinomas : Uncommon clinical presentation in a Bulgarian patient.
    Wien Med Wochenschr 2017 Feb 20. Epub 2017 Feb 20.
    Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany.
    Basal cell carcinoma is the most frequent cutaneous neoplasm, with slowly progressive nature and locally invasive behavior. Despite the low metastatic potential, local tissue destruction and disfigurement caused by the tumor can be large if not eradicated in time by early diagnosis and treatment. Both genetic predisposition and exposure to environmental risks are involved in the pathogenesis of the malignant transformation in BCC. Read More

    Cytology of the neovagina in transgender women and individuals with congenital or acquired absence of a natural vagina.
    Cytopathology 2017 Feb 20. Epub 2017 Feb 20.
    Institute of Clinical Pathology, University Hospital Zurich, Zurich, Switzerland.
    Objective: The primary objective of this study was to describe the cytological findings of bowel and (penile) skin-lined neovaginas in patients with gender dysphoria (GD) and individuals with a congenital or acquired absence of a natural vagina. The secondary objective was to correlate the cytological findings with clinical characteristics such as oestrogen replacement therapy (ERT).

    Methods: A retrospective review of an institutional pathology archive over a 15-year-period was performed to identify cytological samples of neovaginal vaults. Read More

    Inguinal lymph node presenting as the delayed site of metastasis in early stage endometrial carcinoma: Case report.
    Int J Surg Case Rep 2017 Jan 19;32:12-15. Epub 2017 Jan 19.
    Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, 59046, Saudi Arabia. Electronic address:
    Introduction: Inguinal lymph nodes are the frequent sites of metastasis for malignant lymphoma, squamous cell carcinoma of anal canal, vulva and penis, malignant melanoma and squamous cell carcinoma of skin over lower extremities or trunk. Anatomically, endometrial carcinoma is less likely to spread to the superficial or deep inguinal lymph nodes, thus metastatic involvement of these lymph nodes can easily be overlooked.

    Case Presentation: Here-in we report a case of a 65-year old Saudi morbid obese female, who presented with left inguinal lymphadenopathy as initial delayed site of metastasis almost 19 months after the initial treatment for FIGO IA endometrial carcinoma. Read More

    Undermining plastic surgery as a possible option for treating basal cell carcinoma of the forehead.
    Wien Med Wochenschr 2017 Feb 13. Epub 2017 Feb 13.
    Department of Pathology, University of Virginia Health System, 1215 Lee Street, 800214, 22908, Charlottesville, VA, USA.
    Basal cell carcinoma (BCC) is the most common cutaneous cancer. Although most cases can be cured with simple surgical procedures and are associated with a good prognosis, a minority of BCCs may pose significant therapeutic challenges. This occurs mostly in cases of so-called advanced BCC, which a loosely defined term that encompasses locally advanced lesions and tumors with metastatic spread. Read More

    Capecitabine-Associated Loss of Fingerprints: Report of Capecitabine-Induced Adermatoglyphia in Two Women with Breast Cancer and Review of Acquired Dermatoglyphic Absence in Oncology Patients Treated with Capecitabine.
    Cureus 2017 Jan 9;9(1):e969. Epub 2017 Jan 9.
    Department of Dermatology, University of California, San Diego.
    Capecitabine, an oral 5-fluorouracil prodrug, is currently used in the treatment of metastatic colorectal carcinoma and breast cancer. Fingerprints, also referred to as dermatoglyphics and characterized by the pattern of ridges and furrows on the fingertips, are used for identification by government agencies and personal electronic devices. Two women with breast cancer who were treated with capecitabine and developed drug-associated loss of their fingerprints are described. Read More

    Renal Cell Carcinoma Metastatic to the Scalp.
    Rare Tumors 2016 Nov 20;8(4):6400. Epub 2016 Dec 20.
    The University of Texas Southwestern Medical School, Dallas; Veterans' Affairs Hospital, Dallas, TX, USA.
    Because of the asymptomatic natural history of renal cell carcinoma (RCC), by the time a diagnosis is made, metastatic disease is present in about one third of the cases. Thus, the overall survival of patients with RCC remains poor. Ultimately up to 50% of patients with RCC will develop metastases. Read More

    Effectiveness of photodynamic therapy in Bowen's disease: a retrospective observational study in 423 lesions.
    J Eur Acad Dermatol Venereol 2017 Feb 11. Epub 2017 Feb 11.
    Department of Dermatology and Venereology, Sahlgrenska University Hospital, Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Background: Photodynamic therapy (PDT) is a well-known technique that is often used for treating superficial precancerous and cancerous skin lesions. However, only a handful of studies, with a relatively small number of treated lesions, have been carried out on the effectiveness of PDT for Bowen's disease (BD).

    Objectives: This study aimed to assess the effectiveness and recurrence risk of PDT in the treatment of BD. Read More

    Unusual sites of metastases of carcinoma cervix.
    BMJ Case Rep 2017 Feb 7;2017. Epub 2017 Feb 7.
    Department of Radiotherapy, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
    We present a case of metastatic squamous cell carcinoma cervix with solitary bone metastases to the right tibia and multiple cutaneous metastases. A woman aged 52 years with cancer of the cervix and lung metastases, after 21 months of initial diagnosis and palliative chemotherapy presented with pain in the right knee and multiple nodular skin lesions. Bone scintigraphy revealed intense increased tracer activity in the proximal and mid shaft of the right tibia. Read More

    Utility of prospective pathologic evaluation to inform clinical genetic testing for hereditary leiomyomatosis and renal cell carcinoma.
    Cancer 2017 Feb 7. Epub 2017 Feb 7.
    Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
    Background: Patients with hereditary leiomyomatosis and renal cell carcinoma (HLRCC) resulting from fumarate hydratase (FH) mutations may present with skin, uterine, and renal tumors, with each having unique pathologic features. This study investigated the association between prospectively identified suspicious pathology (SP) and FH mutations when patients were referred for genetic testing.

    Methods: This was an institutional review board-approved cohort study of patients receiving FH testing from 2008 to 2013. Read More

    Low-Grade Neuroendocrine Carcinoma of the Skin (Primary Cutaneous Carcinoid Tumor) as a Distinctive Entity of Cutaneous Neuroendocrine Tumors: A Clinicopathologic Study of 3 Cases With Literature Review.
    Am J Dermatopathol 2017 Feb 2. Epub 2017 Feb 2.
    *Department of Diagnostic Pathology, Kainan Hospital, Yatomi, Japan;†Sapporo Dermatopathology Institute, Sapporo, Japan;‡Department of Plastic and Reconstructive Surgery, Saitama Medical University, Saitama, Japan;§Departments of Dermatology, and¶Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan; and‖Department of Breast Surgery, Kainan Hospital, Yatomi, Japan.
    There is scarcity of information on primary cutaneous low-grade neoplasms commonly known as carcinoid tumors, owing to their rarity. The authors present 3 cases that were named "low-grade neuroendocrine carcinoma of the skin" (LGNECS). These occurred in the dermis and subcutis of the anterior chest or the inguinal region in the elderly. Read More

    Drug therapy of advanced cutaneous squamous cell carcinoma: is there any evidence?
    Curr Opin Oncol 2017 Mar;29(2):129-135
    aDepartment of Medical Sciences, Section of Dermatology, University of Turin, Turin bDepartment of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy cMoores Cancer Center, University of California, San Diego, San Diego, California, USA dDepartment of Dermatology, University of Bern, Inselspital, Berne, Switzerland.
    Purpose Of Review: There are few randomized controlled studies to guide the treatment of advanced cutaneous squamous cell carcinoma. The existing treatments are mostly based on case reports and small case series. Here we review recently available insights concerning the treatment of locally advanced and metastatic squamous cell carcinoma, with a special emphasis on novel targeted therapy and immunotherapy. Read More

    Stromal microenvironment in type VII collagen-deficient skin: The ground for squamous cell carcinoma development.
    Matrix Biol 2017 Jan 24. Epub 2017 Jan 24.
    Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Via dei Monti di Creta 104, 00167 Rome, Italy. Electronic address:
    Recessive dystrophic epidermolysis bullosa (RDEB) is a skin fragility disease caused by mutations that affect the function and/or the amount of type VII collagen (C7), the major component of anchoring fibrils. Hallmarks of RDEB are unremitting blistering and chronic wounds leading to tissue fibrosis and scarring. Nearly all patients with severe RDEB develop highly metastatic squamous cell carcinomas (SCC) which are the main cause of death. Read More

    Silibinin Treatment Inhibits the Growth of Hedgehog Inhibitor Resistant Basal Cell Carcinoma Cells via Targeting EGFR-MAPK-Akt and Hedgehog Signaling.
    Photochem Photobiol 2017 Jan 25. Epub 2017 Jan 25.
    Department of Pharmaceutical Sciences, University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus.
    Basal cell carcinoma (BCC) is the most common skin malignancy. Deregulated hedgehog signaling plays a central role in BCC development; therefore hedgehog inhibitors have been approved to treat locally advanced or metastatic BCC. However, the development of resistance to hedgehog inhibitors is the major challenge in effective treatment of this disease. Read More

    Intraepidermal proliferation of Merkel cells within a seborrheic keratosis: Merkel cell carcinoma in situ or Merkel cell hyperplasia?
    J Cutan Pathol 2017 Jan 20. Epub 2017 Jan 20.
    Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania.
    Intradepidermal proliferation of Merkel cells without any dermal component has been interpreted as either a hyperplastic process secondary to chronic ultraviolet radiation or a neoplastic process, namely Merkel cell carcinoma (MCC) in situ. The recent criteria that have been proffered to diagnose MCC in situ, unfortunately, are identical to those that have been applied to Merkel cell hyperplasia in the past, posing a diagnostic quandary when faced with an intraepidermal proliferation of Merkel cells. Most previously reported cases of MCC in situ have occurred within associated epithelial lesion that includes solar (actinic) keratosis and squamous-cell carcinoma in situ. Read More

    Cancer-associated fibroblasts enact field cancerization by promoting extratumoral oxidative stress.
    Cell Death Dis 2017 Jan 19;8(1):e2562. Epub 2017 Jan 19.
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore.
    Histological inspection of visually normal tissue adjacent to neoplastic lesions often reveals multiple foci of cellular abnormalities. This suggests the presence of a regional carcinogenic signal that spreads oncogenic transformation and field cancerization. We observed an abundance of mutagenic reactive oxygen species in the stroma of cryosectioned patient tumor biopsies, indicative of extratumoral oxidative stress. Read More

    Risk of Aggressive Skin Cancers Following Kidney Retransplantation in Patients With Previous Posttransplant Cutaneous Squamous Cell Carcinomas: A Retrospective Study of 53 Cases.
    Transplantation 2017 Jan 17. Epub 2017 Jan 17.
    a Hospices Civils de Lyon, Department of Dermatology, Edouard Herriot Hospital, Lyon, France b Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands c Hospices Civils de Lyon, Pole IMER, Lyon, France d Université de Lyon, Lyon, France e Department of Dermatology, Nantes University Medical Center, Nantes, France f Department of Dermatology, Saint Louis Hospital, APHP, University Paris VII, INSERM U976 Paris, France g Department of Dermatology, Tenon Hospital, APHP, University Paris VI, Paris, France h Department of Transplantation and Nephrology, Edouard Herriot Hospital, Université de Lyon, Lyon, France i Department of Nephrology-Transplantation, Necker Hospital, APHP, Paris, France j Department of Dermatology, Charles-Nicolle University Medical Center, Rouen, France kDepartment of Renal Medicine and Transplantation, Nantes University Medical Center, Nantes, France.
    Background: The course of skin cancer after retransplantation in organ-transplant recipients who have already developed posttransplant skin cancer has not been assessed.

    Methods: This retrospective multicentric study included 53 patients with a history of cutaneous squamous cell carcinoma (SCC) after a first kidney transplantation who received a second kidney transplantation. The primary end-point was the occurrence of aggressive cutaneous SCC after the second transplantation. Read More

    Successful surgical treatment for squamous cell carcinoma arising from hidradenitis suppurativa: A case report and literature review.
    Medicine (Baltimore) 2017 Jan;96(3):e5857
    aDivision of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital, Beijing, P.R. China bDepartment of Medicine, the University of Melbourne, Parkville, Victoria, Australia cDepartment of Pathology, Peking Union Medical College Hospital, Beijing, P.R. China.
    Rationale: Hidradenitis suppurativa (HS) is a disabling inflammatory disease mainly affecting apocrine glands. Marjolin ulcer (MU) is a term used to describe a rare type of squamous cell carcinoma (SCC) arising within sites of chronic wounds or preexisting scars. Chronic HS may result in a rare type of SCC, MU, which has a poor prognosis due to its high metastatic rate. Read More

    Late side-effects and cosmetic results of accelerated partial breast irradiation with interstitial brachytherapy versus whole-breast irradiation after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: 5-year results of a randomised, controlled, phase 3 trial.
    Lancet Oncol 2017 Feb 14;18(2):259-268. Epub 2017 Jan 14.
    Department of Radiation Oncology, University Hospital Erlangen, Erlangen, Germany.
    Background: We previously confirmed the non-inferiority of accelerated partial breast irradiation (APBI) with interstitial brachytherapy in terms of local control and overall survival compared with whole-breast irradiation for patients with early-stage breast cancer who underwent breast-conserving surgery in a phase 3 randomised trial. Here, we present the 5-year late side-effects and cosmetic results of the trial.

    Methods: We did this randomised, controlled, phase 3 trial at 16 centres in seven European countries. Read More

    Successful recovery from a subclavicular ulcer caused by lenvatinib for thyroid cancer: a case report.
    World J Surg Oncol 2017 Jan 14;15(1):24. Epub 2017 Jan 14.
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, 606-8507, Japan.
    Background: There are currently no effective therapeutic methods for locally recurrent, metastatic, or progressive radioactive iodine (RAI)-refractory differentiated thyroid cancer. However, multitargeted tyrosine kinase inhibitors (TKIs) such as lenvatinib or sorafenib have been approved for patients with RAI-refractory differentiated thyroid cancer as a second targeted therapy, and these agents can prolong patient survival. However, several cases have been reported that TKIs have caused fatal complications such as fistula formation or bleeding. Read More

    Giant Anterior Chest Wall Basal Cell Carcinoma: An Approach to Palliative Reconstruction.
    Case Rep Oncol Med 2016 19;2016:5067817. Epub 2016 Dec 19.
    Department of Plastic Surgery, University of California, Irvine, CA, USA.
    Anterior chest wall giant basal cell carcinoma (GBCC) is a rare skin malignancy that requires a multidisciplinary treatment approach. This case report demonstrates the challenges of anterior chest wall GBCC reconstruction for the purpose of palliative therapy in a 72-year-old female. Surgical resection of the lesion included the manubrium and upper four ribs. Read More

    Patterns of Care and Clinical Outcomes in Patients With Metastatic Renal Cell Carcinoma-Results From a Tertiary Cancer Center in India.
    Clin Genitourin Cancer 2016 Oct 19. Epub 2016 Oct 19.
    Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India. Electronic address:
    Introduction: The current treatment of metastatic renal cell carcinoma (mRCC) revolves around targeted agents, which have resulted in a median overall survival of 22 to 26 months in registration trials. However, the outcomes in a non-trial, real-world Indian population have not yet been evaluated.

    Materials And Methods: The present study was a part of a prospective Clinical Trials Registry-India-registered study, the Kidney Cancer Registry, a prospectively maintained kidney cancer registry. Read More

    Anti-metastatic effect of rhodomyrtone from Rhodomyrtus tomentosa on human skin cancer cells.
    Int J Oncol 2017 Mar 9;50(3):1035-1043. Epub 2017 Jan 9.
    Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand.
    This study focused on the inhibitory effect of rhodomyrtone, a bioactive compound isolated from the leaves of Rhodomyrtus tomentosa (Aiton) Hassk., on cancer metastasis in epidermoid carcinoma A431 cells and on the verification of the underlying related molecular mechanisms of this event. We demonstrated that rhodomyrtone at the subcytotoxic concentration (0. Read More

    Pneumonitis in cancer patients receiving anti-PD-1 and radiotherapies: Three case reports.
    Medicine (Baltimore) 2017 Jan;96(1):e5747
    aDepartment of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung bDivision of Hematology/Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei cDivision of Hematology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
    Introduction: In development of novel therapies for the treatment of patient with cancer, the use of radiotherapy (RT) can produce significant local control and, in recent studies, has also been shown to mediate anti-tumor responses at distant sites by triggering and enhancing the endogenous cellular immune responses. Although RT induces an abscopal effect in some patients due to enhanced immune response to the tumor, immune-escape mechanisms, including up-regulation of programmed death-ligand 1 (PD-L1) on tumor cells, limit this benefit in other patients. Hence, many studies have promoted the synergy of RT and anti-programmed cell death protein 1 (PD-1) treatment for antitumor immunity. Read More

    Clinico-pathological factors affecting lymph node yield in Indian patients with locally advanced squamous cell carcinoma of mandibular Gingivo-Buccal sulcus.
    Indian J Cancer 2016 Apr-Jun;53(2):239-243
    Department of Pathology, KLE VK Institute of Dental Sciences, KLE University, Belgaum, Karnataka, India.
    Aim: Lymph node yield (LNY) is a valid marker of prognosis in oral cancer. Precise estimation of LNY in Indian patients with T3/T4 gingivobuccal sulcus squamous cell carcinoma (GBS-SCC) has not been well documented. Hence, the primary objective of the study was to determine the LNY in patients with T3/T4 SCC of mandibular GBS, and the secondary objective was to study the association of LNY with clinicopathological factors such as tumor thickness, histological differentiation, number of positive nodes, and extracapsular spread (ECS). Read More

    CT-guided percutaneous microwave ablation of pulmonary malignant tumors.
    J Thorac Dis 2016 Oct;8(Suppl 9):S659-S665
    Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan.
    Background: Microwave ablation (MWA) of lung tumors is a new approach for local tumor control. The purpose of this retrospective study was to evaluate the preliminary results of safety and efficacy of MWA with a dynamic frequency range (902-928 MHz) and power (10-32 W) for local tumor control of thoracic malignancies.

    Methods: From December 1, 2013 to February 1, 2016, there were total 32 lung tumors among 15 patients (7 men, 8 women, age range 43-82 years, mean 57. Read More

    Extramammary Paget's Disease of Anal Canal Associated With Rectal Adenoma Without Invasive Carcinoma.
    Gastroenterology Res 2016 Dec 23;9(6):99-102. Epub 2016 Dec 23.
    Pathology and Laboratory Medicine, Albany Medical College, Albany, NY, USA.
    Extramammary Paget's disease (EMPD) is a rare disease which is found in apocrine-rich locations such as anogenital region, axilla and rarely in other sites. Perianal EMPD is often reported as the involvement of perianal skin, but involvement of anal mucosa is very rare. Based on pathogenesis and association with either synchronous or metachronous malignancy, EMPD can be divided into primary and secondary types. Read More

    Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions.
    PLoS One 2016 28;11(12):e0168031. Epub 2016 Dec 28.
    Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America.
    The Hedgehog pathway is a potent regulator of cellular growth and plays a central role in the development of many cancers including basal cell carcinoma (BCC). The majority of BCCs arise from mutations in the Patched receptor resulting in constitutive activation of the Hedgehog pathway. Secondary driver mutations promote BCC oncogenesis and occur frequently due to the high mutational burden resulting from sun exposure of the skin. Read More

    Metastatic Squamous Cell Carcinoma of the Pleura: A Rare Complication of Hidradenitis Suppurativa.
    Am J Case Rep 2016 Dec 28;17:989-992. Epub 2016 Dec 28.
    Division of Pulmonary, Critical Care and Sleep Medicine, University of Tennessee Health Sciences Center, Memphis, TN, USA.
    BACKGROUND Squamous cell carcinoma (SCC), also known as Marjolin ulcer, is a rare complication of hidradenitis suppurativa (HS). Metastatic SCC from HS typically involves the axial skeleton or abdominopelvic viscera. Metastatic disease to the lungs is a rare phenomenon with only three reported cases of lung parenchyma. Read More

    Cystic metastatic lymph nodes in malignant melanoma: a case report.
    Clin Imaging 2017 Mar - Apr;42:158-160. Epub 2016 Dec 15.
    Columbia University Medical Center, Herbert Irving Pavilion, 161 Fort Washington Ave., 10th Floor, New York, NY 10032, United States. Electronic address:
    Melanoma is a rare type of skin cancer with a high mortality rate. Local invasion and metastatic spread are primarily responsible for the morbidity and mortality of melanoma. While metastatic lesions vary from cystic to solid, cystic metastases can be challenging to diagnose. Read More

    Cutaneous Metastasis: A Study of 138 Cases Diagnosed by Fine-Needle Aspiration Cytology.
    Acta Cytol 2017 22;61(1):47-54. Epub 2016 Dec 22.
    Department of Pathology, Government Medical College and Hospital, Chandigarh, India.
    Background: Cutaneous metastases can occur in a wide variety of internal malignancies and may be the first sign of a clinically silent visceral cancer.

    Study Design: A retrospective analysis was made of 138 cases diagnosed with cutaneous and subcutaneous metastasis on fine-needle aspiration cytology (FNAC). Primary tumors of the skin/subcutis were excluded. Read More

    FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi-institutional study of 184 cases.
    Cancer 2017 Feb 21;125(2):91-103. Epub 2016 Dec 21.
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Background: Secondary malignancies of salivary glands (SMSGs) are among the most common malignant neoplasms to involve the salivary glands. Fine-needle aspiration biopsy (FNAB) of SMSG can present diagnostic challenges. The current report presents the largest such FNAB series to date. Read More

    Primary cutaneous histiocytoid carcinoma with distant metastasis.
    J Cutan Pathol 2016 Dec 21. Epub 2016 Dec 21.
    Department of Dermatology, The University of Texas Medical Branch, Galveston, Texas.
    Distinguishing primary cutaneous adnexal carcinoma from metastatic carcinoma of unknown primary can be a diagnostic challenge due to the frequent overlap of histologic and immunohistochemical features. A 58-year-old man presented with a tender, indurated plaque on axillary skin. Biopsy revealed infiltrating atypical cells throughout the dermis, without connection to the epidermis. Read More

    Fine-needle aspiration of skin metastasis in ovarian cancer-report of two cases and review of the literature.
    Ann Transl Med 2016 Nov;4(22):447
    Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    Ovarian cancer is known to be the first cause of death of gynecological malignancy in Europe and United States. Skin metastases consist of an unusual event during the course of ovarian carcinoma and occur in 2-3.5% of the patients. Read More

    Characterization of nivolumab-associated skin reactions in patients with metastatic non-small cell lung cancer.
    Oncoimmunology 2016 19;5(11):e1231292. Epub 2016 Sep 19.
    Department of Dermatology and Allergology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland; Institute of Immunobiolology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland; Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.
    Immune checkpoint inhibitors have led to considerable therapy improvement in cancer patients. Autoimmune side effects including skin reactions are frequently observed. In melanoma, those include rash and vitiligo and were shown to be associated with a prolonged overall survival. Read More

    Expression of claudin-11 by tumor cells in cutaneous squamous cell carcinoma is dependent on the activity of p38δ.
    Exp Dermatol 2016 Dec 19. Epub 2016 Dec 19.
    Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland.
    The incidence of cutaneous squamous cell carcinoma (cSCC) is rapidly increasing and the prognosis of patients with metastatic disease is poor. There is an emerging need to identify molecular markers for predicting aggressive behavior of cSCC. Here, we have examined the role of tight junction components in the progression of cSCC. Read More

    Head and neck nonmelanoma cutaneous malignancy treatment in a skin cancer referral center.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Feb 13;123(2):183-187. Epub 2016 Oct 13.
    Consultant Oral and Maxillofacial Surgeon, Northampton General Hospital, UK.
    Objective: The purpose of our study was to determine the level of accuracy provided by clinical diagnosis in head and neck cutaneous malignancy as confirmed by histopathologic examination of the specimen in a skin cancer referral center. Positive predictive value was selected as a reliable measure of diagnostic accuracy. We also aimed to audit our surgical outcomes and record and present the completeness of excision, the rates of recurrence and metastasis, and the reconstructive method. Read More

    Merkel cell carcinoma: Epidemiology, prognosis, therapy and unmet medical needs.
    Eur J Cancer 2017 Jan 14;71:53-69. Epub 2016 Dec 14.
    Translational Skin Cancer Research (TSCR), German Cancer Consortium Partner Site Essen/Düsseldorf, Dermatology, Essen University Hospital, Essen, Germany. Electronic address:
    Merkel cell carcinoma (MCC) is a rare skin cancer that is associated with Merkel cell polyomavirus infection in most cases. Incidence rates of MCC have increased in past decades. Risk factors for MCC include ultraviolet light exposure, immunosuppression and advanced age. Read More

    Sorafenib dose escalation in treatment-naïve patients with metastatic renal cell carcinoma: a non-randomised, open-label, Phase 2b study.
    BJU Int 2016 Dec 15. Epub 2016 Dec 15.
    Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ, USA.
    Objective: To assess the efficacy and safety of sorafenib dose escalation in metastatic renal cell carcinoma (mRCC).

    Patients And Methods: Intra-patient dose escalation may enhance the clinical benefit of targeted anticancer agents in metastatic disease. In this non-randomised, open-label, Phase 2b study, treatment-naïve patients with mRCC were initially treated with the standard oral sorafenib dose [400 mg twice daily (BID)]. Read More

    Phase I/II Randomized Trial of Sorafenib and Bevacizumab as First-Line Therapy in Patients with Locally Advanced or Metastatic Hepatocellular Carcinoma: North Central Cancer Treatment Group Trial N0745 (Alliance).
    Target Oncol 2016 Dec 9. Epub 2016 Dec 9.
    Mayo Clinic, 200 First Street, SW, Rochester, MN, 55905, USA.
    Background: Angiogenesis has been a major target of novel drug development in hepatocellular carcinoma (HCC). It is hypothesized that the combination of two antiangiogenic agents, sorafenib and bevacizumab, will provide greater blockade of angiogenesis.

    Objective: To determine the optimal dose, safety, and effectiveness of dual anti-angiogenic therapy with sorafenib and bevacizumab in patients with advanced HCC. Read More

    HATT: a phase IV, single-arm, open-label study of sorafenib in Taiwanese patients with advanced hepatocellular carcinoma.
    Hepatol Int 2016 Dec 1. Epub 2016 Dec 1.
    Global Clinical Development Oncology, Bayer Healthcare Pharmaceuticals, 100 Bayer Road, Whippany, NJ, USA.
    Background: Sorafenib significantly improves survival in patients with advanced hepatocellular carcinoma (HCC). This phase IV study assessed sorafenib efficacy/safety in Taiwanese patients with advanced HCC and Child-Pugh A status.

    Methods: All patients received 400 mg sorafenib BID. Read More

    Differential mutation frequencies in metastatic cutaneous squamous cell carcinomas versus primary tumors.
    Cancer 2016 Dec 1. Epub 2016 Dec 1.
    Department of Cancer Biology and Genetics, The Ohio State Wexner Medical Center, The Ohio State University, Columbus, Ohio.
    Background: Exome and targeted sequencing studies have identified potential driver mutations for a variety of tumor types. Cutaneous squamous cell carcinoma (cSCC) is one of the most highly mutated cancers but typically is associated with low rates of metastasis and high survival rates. Nevertheless, metastatic cSCC is a significant health threat; up to 8800 individuals die each year of this disease. Read More

    Metastatic spinal cord compression from basal cell carcinoma of the skin treated with surgical decompression and vismodegib: case report and review of Hedgehog signalling pathway inhibition in advanced basal cell carcinoma.
    Clin Exp Dermatol 2017 Jan 30;42(1):80-83. Epub 2016 Nov 30.
    Department of Oncology, Royal Cornwall Hospital, Truro, Cornwall.
    We report a case of a 66-year-old man with locally advanced and metastatic basal cell carcinoma (BCC) causing spinal cord compression, which was treated with spinal surgery and subsequent vismodegib. The patient presented with a large fungating chest wall lesion and a metastasis in T8 that was causing cord compression. He had neurosurgical decompression of the T8 lesion and fixation of the spine. Read More

    Sunitinib in the treatment of metastatic renal cell carcinoma.
    Ther Adv Urol 2016 Dec 23;8(6):348-371. Epub 2016 Aug 23.
    Royal Marsden NHS Foundation Trust, London, UK.
    Sunitinib is an oral multi-targeted tyrosine kinase inhibitor (TKI) that targets various receptors, including vascular endothelial growth factor receptors (VEGFRs). Sunitinib received approval in 2006 and became a standard treatment option in the first-line treatment of metastatic renal cell cancer (mRCC) after a phase III trial showed superiority compared with interferon alpha (IFN-α). Sunitinib has also shown activity in second-line treatment in several trials. Read More

    Unravelling site-specific breast cancer metastasis: a microRNA expression profiling study.
    Oncotarget 2017 Jan;8(2):3111-3123
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
    Distant metastasis is still the main cause of death from breast cancer. MicroRNAs (miRs) are important regulators of many physiological and pathological processes, including metastasis. Molecular breast cancer subtypes are known to show a site-specific pattern of metastases formation. Read More

    Synchronous papillary urothelial carcinoma of the bladder and squamous cell carcinoma with sarcomatoid differentiation: A case report.
    Oncol Lett 2016 Nov 30;12(5):3475-3477. Epub 2016 Aug 30.
    Department of Dermatology, Sakarya University Training and Research Hospital, Adapazari, 54100 Sakarya, Turkey.
    The incidence rate of multiple primary tumors is 37% in all types of cancer. A patient diagnosed with primary cancer is 1.29 times more likely to develop an additional primary cancer when compared with the general population. Read More

    Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition.
    Cell Stem Cell 2017 Feb 23;20(2):191-204.e5. Epub 2016 Nov 23.
    Université libre de Buxelles (ULB), Institut de recherche interdisciplinaire en biologie humaine et moléculaire (IRIBHM), 808 route de Lennik, 1070 Brussels, Belgium; WELBIO, Université Libre de Bruxelles (ULB), 1070 Bruxelles, Belgium. Electronic address:
    Epithelial to mesenchymal transition (EMT) in cancer cells has been associated with metastasis, stemness, and resistance to therapy. Some tumors undergo EMT while others do not, which may reflect intrinsic properties of their cell of origin. However, this possibility is largely unexplored. Read More

    Preliminary results of comparative study for subsequent photodynamic therapy versus secondary excision after primary excision for treating basal cell carcinoma.
    Photodiagnosis Photodyn Ther 2016 Nov 22. Epub 2016 Nov 22.
    Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, 12 Jiangwangmiao St, Nanjing, 210042, China. Electronic address:
    Some basal cell carcinomas (BCCs) are indistinguishable from nevi based on clinical manifestations. Therefore, it is often difficult for the excision margins of the initial surgical treatment to achieve radical removal of the malignancy. This study was a comparative analysis of the clinical results of aminolevulinic acid (ALA)-photodynamic therapy (PDT) or secondary surgery after the primary excision. Read More

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