153,229 results match your criteria Metastatic Carcinoma


The Role of Anti-PD-1/PD-L1 in the Treatment of Skin Cancer.

BioDrugs 2020 May 23. Epub 2020 May 23.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Skin cancers remain the most common group of cancers globally, and the incidence continues to rise. Although localized skin cancers tend to have excellent outcomes following surgical excisions, the less common cases that become surgically unresectable or metastatic have been associated with poor prognosis and suboptimal treatment responses to cytotoxic chemotherapy. Development of monoclonal antibodies to programmed cell death-1 receptor and its ligand (PD-1/PD-L1) have transformed the management of metastatic melanoma, squamous cell carcinoma, and Merkel cell carcinoma. Read More

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http://dx.doi.org/10.1007/s40259-020-00428-9DOI Listing

The paratumoral immune cell signature reveals the potential for the implementation of immunotherapy in esophageal carcinoma patients.

J Cancer Res Clin Oncol 2020 May 23. Epub 2020 May 23.

Department of Immunology, Second Faculty of Medicine, Charles University and University Hospital Motol, V Uvalu 84, Praha 5, 150 06, Prague, Czech Republic.

Purpose: Esophageal cancer (EC) is one of the most lethal gastrointestinal malignancies. Immunotherapy is a promising treatment modality for this disease. However, broader implementation of EC immunotherapy has been discouraged because of insufficient understanding of tumor interactions with the immune system. Read More

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http://dx.doi.org/10.1007/s00432-020-03258-yDOI Listing

Treatment of High-grade Non-muscle-invasive Bladder Carcinoma by Standard Number and Dose of BCG Instillations Versus Reduced Number and Standard Dose of BCG Instillations: Results of the European Association of Urology Research Foundation Randomised Phase III Clinical Trial "NIMBUS".

Eur Urol 2020 May 20. Epub 2020 May 20.

EAU Research Foundation, Arnhem, The Netherlands.

Background: Intravesical instillation of bacillus Calmette-Guérin (BCG) is an accepted strategy to prevent recurrence of non-muscle-invasive bladder cancer (NMIBC) but associated with significant toxicity.

Objective: NIMBUS assessed whether a reduced number of standard-dose BCG instillations are noninferior to the standard number and dose in patients with high-grade NMIBC.

Design, Setting, And Participants: A total of 345 patients from 51 sites were randomised between December 2013 and July 2019. Read More

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http://dx.doi.org/10.1016/j.eururo.2020.04.066DOI Listing

Antioxidants suppress radiation-induced apoptosis via inhibiting MAPK pathway in nasopharyngeal carcinoma cells.

Biochem Biophys Res Commun 2020 May 20. Epub 2020 May 20.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China; Department of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China; Guangzhou Concord Cancer Center, Guangzhou, China. Electronic address:

Nasopharyngeal carcinoma (NPC) is relatively sensitive to ionizing radiation, and radiotherapy is the main treatment modality for non-metastatic NPC. Radiation therapy generates overproduction of reactive oxygen species (ROS), which can cause DNA damage and induce apoptosis in tumors, thereby killing the malignant cells. Although dietary antioxidant supplementation reduces oxidative stress and promotes tumor progression, the effects of antioxidants on the NPC cells upon radiation have not been reported. Read More

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http://dx.doi.org/10.1016/j.bbrc.2020.04.093DOI Listing

Is Merkel Cell Carcinoma of Lymph Node Actually Metastatic Cutaneous Merkel Cell Carcinoma?

Am J Clin Pathol 2020 May 23. Epub 2020 May 23.

Department of Pathology, Stanford University School of Medicine, Stanford, CA.

Objectives: The possibility of a so-called primary lymph node neuroendocrine carcinoma has been described in the literature. Here we evaluate cases fitting such a diagnosis and find that the cases demonstrate a convincing and pervasive pattern consistent with metastatic Merkel cell carcinoma.

Methods: Six cases of primary lymph node Merkel cell carcinoma and one case of metastatic neuroendocrine carcinoma at a bony site, all with unknown primary, were sequenced using a combination of whole-exome and targeted panel methods. Read More

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http://dx.doi.org/10.1093/ajcp/aqaa051DOI Listing

Study of ER, PR, HER2/neu, p53, and Ki67 expression in primary breast carcinomas and synchronous metastatic axillary lymph nodes.

Indian J Cancer 2020 Apr-Jun;57(2):190-197

Department of Pathology, Shrimati Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India.

Background: Breast cancer (BCA) is the second most common cancer among women in India and accounts for 7% of global burden of BCA. The axillary lymph node status is an independent prognostic factor. The combined estrogen receptor (ER), progesterone receptor (PR), and HER2/neu biomarker expression is a predictor of BCA status for therapeutic guidance. Read More

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http://dx.doi.org/10.4103/ijc.IJC_610_18DOI Listing

Uro-oncology in times of COVID-19: The available evidence and recommendations in the Indian scenario.

Indian J Cancer 2020 Apr-Jun;57(2):129-138

Department of Urology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

The Corona Virus Disease-2019 (COVID-19), one of the most devastating pandemics ever, has left thousands of cancer patients to their fate. The future course of this pandemic is still an enigma, but health care services are expected to resume soon in a phased manner. This might be a long drawn process and we need to have policies in place, to be able to fight both, the SARS-CoV-2 virus and cancer, simultaneously, and emerge triumphant. Read More

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http://dx.doi.org/10.4103/ijc.IJC_356_20DOI Listing

β-Arrestin1 involves in hepatocellular carcinoma metastasis via ERK mediated epithelial-mesenchymal transition.

J Gastroenterol Hepatol 2020 May 22. Epub 2020 May 22.

Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Background And Aim: Hepatocellular carcinoma (HCC) is a malignant disease worldwide. It is implicated in high cancer-related mortality rates in humans. β-Arrestin1 (ARRB1) has been demonstrated to be related to the development of several cancers, while the relationship between ARRB1 and metastasis in HCC is unknown. Read More

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http://dx.doi.org/10.1111/jgh.15115DOI Listing

Association Between Systemic Therapy and/or Cytoreductive Nephrectomy and Survival in Contemporary Metastatic Non-clear Cell Renal Cell Carcinoma Patients.

Eur Urol Focus 2020 May 19. Epub 2020 May 19.

Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Quebec, Canada.

Background: Optimal management of metastatic non-clear cell renal cell carcinoma (non-ccmRCC) remains largely unknown.

Objective: To test the effect of systemic therapy (ST) and/or cytoreductive nephrectomy (CNT) on overall mortality (OM) in patients with non-ccmRCC.

Design, Setting, And Participants: Within the Surveillance, Epidemiology and End Results (SEER) registry (2006-2015), we identified patients with papillary, chromophobe, sarcomatoid, and collecting duct metastatic renal cell carcinoma (mRCC). Read More

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http://dx.doi.org/10.1016/j.euf.2020.04.009DOI Listing

Non-Invasive Papillary Urothelial Carcinoma with "Micropapillary" Architecture: Clinicopathologic Study of 18 Patients Emphasizing Clinical Outcomes.

Histopathology 2020 May 22. Epub 2020 May 22.

Cleveland Clinic, Pathology, Cleveland, OH, USA.

Aim: Invasive micropapillary carcinoma is a recognized aggressive urothelial carcinoma variant. One prior study focusing on non-invasive (pTa) high grade papillary urothelial carcinoma with micropapillary architecture has been reported.

Methods And Results: We collected bladder transurethral resection specimens showing non-invasive high grade papillary urothelial carcinoma with non-hierarchical secondary papillae lacking fibrovascular cores (i. Read More

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http://dx.doi.org/10.1111/his.14161DOI Listing

FUT7 promotes the malignant transformation of follicular thyroid carcinoma through α1,3-Fucosylation of EGF receptor.

Exp Cell Res 2020 May 19:112095. Epub 2020 May 19.

Department of Pathology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China. Electronic address:

Aberrant protein glycosylation is involved in many diseases including cancer. This study investigated the role of fulcosytransferase VII (FUT7) in the progression of follicular thyroid carcinoma (FTC). FUT7 expression was found to be upregulated in FTC compared to paracancerous thyroid tissue, and in FTC with T2 stage of TMN classification compared to FTC with T1 stage. Read More

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http://dx.doi.org/10.1016/j.yexcr.2020.112095DOI Listing

Real-world use of sorafenib for advanced renal cell carcinoma patients with cardiovascular disease: nationwide survey in Japan.

Expert Rev Anticancer Ther 2020 May 22. Epub 2020 May 22.

Research Centre for Advanced Science and Technology, The University of Tokyo , Tokyo, Japan.

Objectives: To assess whether the clinical outcome of advanced/metastatic renal cell carcinoma (mRCC) treated with sorafenib, in real-world conditions, differs in patients with cardiovascular disease (CVD).

Methods: mRCC patients (n=2256 before matching) were matched by propensity score into CVD (n=560) and non-CVD groups (n=560), followed by safety and effectiveness analyses.

Results: After matching, patients' features used for matching were balanced between the CVD and non-CVD groups, except for age (p=0. Read More

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http://dx.doi.org/10.1080/14737140.2020.1773805DOI Listing

A prospective randomized trial of desmopressin in canine mammary carcinoma.

Vet Comp Oncol 2020 May 22. Epub 2020 May 22.

Department of Clinical Studies- New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA.

Metastatic disease represents a serious and often fatal development in patients with solid tumors, including women with breast cancer and dogs with mammary tumors. Therefore, preventing and treating metastatic disease has remained a priority in cancer research. Desmopressin, a synthetic derivative of vasopressin, traditionally used to treat patients with bleeding disorders, has been proposed as a potential antimetastatic agent due to its effect on hemostasis as well as multiple other antiproliferative and antiangiogenic mechanisms. Read More

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http://dx.doi.org/10.1111/vco.12619DOI Listing

Hematological predictive markers for recurrent or metastatic squamous cell carcinomas of the head and neck treated with nivolumab: A multicenter study of 88 patients.

Cancer Med 2020 May 22. Epub 2020 May 22.

Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University School of Medicine, Sagamihara, Japan.

Background: There is increasing evidence that immunotherapy with nivolumab, an anti-programmed death 1 monoclonal antibody, is effective in the treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). However, the predictive role of hematological inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR) and the modified Glasgow prognostic score (mGPS) in patients with R/M SCCHN treated with nivolumab remains unclear.

Methods: We conducted a multi-institutional cohort study to evaluate the impact of pretreatment NLR and mGPS on overall survival (OS) and progression-free survival (PFS) in patients with R/M SCCHN treated with nivolumab in Japan. Read More

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http://dx.doi.org/10.1002/cam4.3124DOI Listing

Efficacy of combining electric-field and C-plane imaging to obtain ultrasound-ultrasound fusion images in monopolar radiofrequency ablation for patients with liver cancer.

Hepatol Res 2020 May 22. Epub 2020 May 22.

Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa 454, Toon, Ehime, 791-0295, Japan.

Aim: For radiofrequency ablation to treat patients diagnosed with liver cancer, the ablation area cannot be envisaged beforehand, even by experts. This study aimed to assess the clinical feasibility of applying a combination of electric-field (E-field) and coronal (C)-plane simulations to ultrasound-ultrasound (US-US) fusion images.

Methods: The study protocols were approved by the institutional ethics committee. Read More

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http://dx.doi.org/10.1111/hepr.13527DOI Listing

Human T cells interacting with HNSCC-derived mesenchymal stromal cells acquire Tissue-Resident memory like properties.

Eur J Immunol 2020 May 22. Epub 2020 May 22.

Department of Experimental and Clinical Medicine, University of Florence, Firenze, 50121, Italy.

Tissue-resident memory (Trm) cells are specialized components of both CD4+ and CD8+ T cell subsets that persist in peripheral non-lymphoid tissues following infections and provide fast response in case of a secondary invasion by the same pathogen. Trm cells express the surface markers CD69, CD103 and the immune checkpoint molecule PD-1. Trm cells develop not only in the context of infections but also in tumors, where they can provide a line of defense as suggested by the positive correlation between the frequency of tumor-infiltrating Trm cells and patients' survival. Read More

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http://dx.doi.org/10.1002/eji.202048544DOI Listing

Positive consequences of splenectomy for patients with schistosomiasis-induced variceal bleeding.

Surg Endosc 2020 May 21. Epub 2020 May 21.

Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.

Background: Patients with hepatic schistosomiasis are at high risk of gastroesophageal variceal bleeding, which is highly torrential and life threatening. This study aimed to assess the effects of splenectomy on patients with schistosomiasis-induced variceal bleeding, especially those influences related to overall survival (OS) rate.

Methods: From January 2005 to December 2018, 112 patients with schistosomiasis-induced varices were enrolled. Read More

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http://dx.doi.org/10.1007/s00464-020-07648-8DOI Listing

Diagnostic performance of Liver Imaging Reporting and Data System in patients at risk of both hepatocellular carcinoma and metastasis.

Abdom Radiol (NY) 2020 May 21. Epub 2020 May 21.

Department of Radiology, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.

Objective: The purpose of this study was to evaluate the diagnostic performance of the Liver Imaging Reporting and Data System (LI-RADS) in patients with both chronic liver disease and a history of extrahepatic malignancy.

Materials And Methods: This retrospective study included 59 hepatocellular carcinomas (HCCs) and 45 metastases pathologically confirmed between 2008 and 2017 in 104 patients with chronic liver disease (cirrhosis or chronic hepatitis B) and a history of extrahepatic malignancy. Two radiologists blinded to the final diagnosis independently reviewed MRI (95 patients) or CT (9 patients) images, and their consensus data were used to calculate the diagnostic performance of LI-RADS categories. Read More

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http://dx.doi.org/10.1007/s00261-020-02581-9DOI Listing

The Clinical Value of Postoperative Transarterial Chemoembolization for Resectable Patients with Intermediate Hepatocellular Carcinoma After Radical Hepatectomy: a Propensity Score-Matching Study.

J Gastrointest Surg 2020 May 21. Epub 2020 May 21.

Department of Hepatopancreatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Xihong Road 312, Fuzhou, 350025, Fujian, People's Republic of China.

Background And Aims: Surgical resection for patients with intermediate hepatocellular carcinoma (HCC) is preferred in China, but the prognosis remains far from satisfactory. Postoperative transarterial chemoembolization (p-TACE) has been conducted prevalently to prevent recurrence, but its efficacy remains controversial. Hence, we collected the data from primary liver cancer big data (PLCBD) to investigate the clinical value of p-TACE for patients with intermediate HCC and identify the potential beneficiaries. Read More

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http://dx.doi.org/10.1007/s11605-020-04588-5DOI Listing

Good Visual Outcome Following Corticosteroid Treatment for Compressive Optic Neuropathy Secondary to Sinonasal Carcinoma.

Cureus 2020 Apr 18;12(4):e7732. Epub 2020 Apr 18.

Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MYS.

Most patients with sinonasal carcinoma present to the otorhinolaryngologist with nasal symptoms. It is however uncommon for them to present with acute visual loss at first presentation. We report a case of compressive optic neuropathy secondary to sinonasal carcinoma, which presented acutely with right eye blurring of vision upon waking up. Read More

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http://dx.doi.org/10.7759/cureus.7732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237059PMC

Peripheral leg ischemia detected via intraoperative neurophysiological monitoring during a multilevel complex anterior and posterior operation.

J Surg Case Rep 2020 May 18;2020(5):rjaa049. Epub 2020 May 18.

Division of Orthopaedic Surgery, University of Manitoba, Winnipeg, Canada.

Intraoperative neurophysiologic monitoring is a technique utilized during spinal operations to minimize sensory and motor function morbidity. We herein report a case of a 73-year-old female with renal cell carcinoma and metastatic involvement of the cervical and thoracic spine, who underwent a multilevel complex anterior and posterior operation. Neurophysiological monitoring was able to localize the lower limb ischemia utilizing somatosensory evoked potentials. Read More

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http://dx.doi.org/10.1093/jscr/rjaa049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232934PMC

Accelerates Hepatocellular Carcinoma Progression by Driving the Epithelial-to-Mesenchymal Transition.

Onco Targets Ther 2020 8;13:3931-3942. Epub 2020 May 8.

Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, People's Republic of China.

Introduction: A poor prognosis owing to cancer invasion and metastasis, hepatocellular carcinoma (HCC) is one of the leading causes of malignancy deaths worldwide. A dominant epithelial-to-mesenchymal transition or EMT function in tumour metastasis is substantially evidenced. Prior reports identified a likely correlation of the nuclear hormone receptor with HCC progression, but the underlying molecular mechanisms and role of invasion and metastasis are still to be adequately documented. Read More

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http://dx.doi.org/10.2147/OTT.S237804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217318PMC

Personalized neoantigen-based immunotherapy for advanced collecting duct carcinoma: case report.

J Immunother Cancer 2020 May;8(1)

The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China

Background: Collecting duct carcinoma (CDC) of the kidney is a rare and highly aggressive malignant tumor with the worst prognosis among all renal cancers. Nevertheless, the first-line treatments, including chemotherapy and target therapy, usually show poor response to CDC. Recent studies have suggested that immunotherapy targeting personal tumor-specific neoantigens could be a promising strategy for several solid cancers. Read More

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http://dx.doi.org/10.1136/jitc-2019-000217DOI Listing

Previously undiagnosed neuroendocrine tumour mimicking breast cancer metastasis to the orbit.

BMJ Case Rep 2020 May 20;13(5). Epub 2020 May 20.

Department of Ophthalmology and Vision Science, University of California Davis Health Eye Center, Sacramento, California, USA

Metastatic neuroendocrine neoplasms to the breast are rare and histopathologic overlap with mammary carcinomas has led to misdiagnosis. We present a case of a middle-aged woman with diplopia and a right medial rectus mass. Metastatic breast cancer was initially suspected based on a history of invasive ductal carcinoma. Read More

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http://dx.doi.org/10.1136/bcr-2020-234629DOI Listing

Overall survival and PD-L1 expression in patients with recurrent or metastatic head and neck cancer treated with nivolumab.

Auris Nasus Larynx 2020 May 18. Epub 2020 May 18.

Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Objective: Our facility measures programmed cell death ligand 1 (PD-L1) expression in all patients before administering nivolumab. The aim of the present study is to clarify the association between overall survival (OS) and PD-L1 expression.

Patients And Methods: Subjects in this study were 52 patients with R/M-HNC cancer (45 men, 7 women) administered nivolumab in our facility between June 1, 2017 and January 31, 2019. Read More

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http://dx.doi.org/10.1016/j.anl.2020.04.001DOI Listing

Chemical, Bioactivity, and Biosynthetic Screening of Epiphytic Fungus .

Molecules 2020 May 19;25(10). Epub 2020 May 19.

Department of Chemistry, Oregon State University, Corvallis, OR 97331, USA.

We report the first secondary metabolite, 8,8'-bijuglone, obtained from pure cultures of the slow growing Douglas fir- ( var. ) foliage-associated fungus . The quinone was characterized using extensive LC/MS and NMR-based spectroscopic methods. Read More

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http://dx.doi.org/10.3390/molecules25102358DOI Listing

Increasing burden of advanced hepatocellular carcinoma in New Zealand-the need for better surveillance.

N Z Med J 2020 May 22;133(1515):25-34. Epub 2020 May 22.

New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland.

Background: Regular surveillance for hepatocellular carcinoma (HCC) in patients with chronic hepatitis B viral (HBV) infection and hepatitis C (HCV) cirrhosis improves survival by earlier detection of the cancer at an earlier stage when curative intervention may still be possible. We compared patient characteristics, surveillance history and outcomes in patients presenting with advanced HCC secondary to HBV and HCV.

Method: In this retrospective study, clinical databases and notes were reviewed in all cases of advanced HCC related to HBV or HCV referred to the tertiary HCC service in Auckland, New Zealand between 1 January 2003 and 31 December 2017. Read More

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Pseurotin A as a novel suppressor of hormone dependent breast cancer progression and recurrence by inhibiting PCSK9 secretion and interaction with LDL receptor.

Pharmacol Res 2020 May 11;158:104847. Epub 2020 May 11.

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA, 71201, USA. Electronic address:

Hypercholesterolemia has been documented to drive hormone-dependent breast cancer (BC) progression and resistance to hormonal therapy. Proprotein convertase subtilisin/kexin type-9 (PCSK9) regulates cholesterol metabolism through binding to LDL receptor (LDLR) and targeting the receptor for lysosomal degradation. Inhibition of PCSK9 is an established strategy to treat hypercholesterolemia. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.104847DOI Listing
May 2020
4.408 Impact Factor

Intramedullary-Extramedullary Breast Metastasis to the Caudal Neuraxis Two Decades after Primary Diagnosis: Case Report and Review of the Literature.

World Neurosurg 2020 May 10. Epub 2020 May 10.

Department of Neurosurgery, Beth Israel Deaconess Medical Center, Lowry Medical Office Building, 110 Francis St Ste 3B, Boston, MA, 02215, USA.

Background: Intramedullary metastases to the caudal neuraxis with exophytic extension to the extramedullary space are rare. We describe the unique case of a patient with locally recurrent breast cancer who developed an intramedullary-extramedullary metastasis to the conus medullaris and cauda equina twenty-two years after primary diagnosis, the longest interval between primary breast cancer and intramedullary spread to date. We also review the published literature on focal breast metastases to the conus medullaris or cauda equina. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.002DOI Listing

Substance P accelerates the progression of human esophageal squamous cell carcinoma via MMP-2, MMP-9, VEGF-A, and VEGFR1 overexpression.

Mol Biol Rep 2020 May 20. Epub 2020 May 20.

Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Tachykinins such as Substance P (SP) are a group of neuropeptides that are involved in cancer development. Neurokinin-1 receptor (NK-1R) is the main tachykinin receptor mediating the effects of SP, which is overexpressed in human esophageal squamous cell carcinoma (ESCC) and other malignant tissues. However, the effects of SP/NK-1R system on the migration of esophageal cancer cells and angiogenesis is not clear yet. Read More

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http://dx.doi.org/10.1007/s11033-020-05532-1DOI Listing

Incidence of Pericardial Effusion in Patients with Advanced Non-Small Cell Lung Cancer Receiving Immunotherapy.

Adv Ther 2020 May 20. Epub 2020 May 20.

S.C. Cardiologia, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Napoli, Italy.

Introduction: Cardiovascular toxicity of immunotherapy represents an underreported but potentially fatal side effect. A relatively high incidence of pericardial disease has been noticed in patients with non-small cell lung cancer (NSCLC).

Methods: We retrospectively analyzed a population of patients with advanced NSCLC receiving immune checkpoint inhibitors (ICIs) looking for the presence of pericardial effusion at baseline or during treatment. Read More

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http://dx.doi.org/10.1007/s12325-020-01386-yDOI Listing

Study Protocol of the ESAP Study: Endoscopic Papillectomy vs. Surgical Ampullectomy vs. Pancreaticoduodenectomy for Ampullary Neoplasm-A Pancreas2000/EPC Study.

Front Med (Lausanne) 2020 6;7:152. Epub 2020 May 6.

Department of Digestive, Hepatobiliary and Endocrine Surgery, Paris Descartes University, Cochin Hospital, Paris, France.

Lesions of the Ampulla of Vater are a rare condition and represent <10% of peri-ampullary neoplasms. Nevertheless, ampullary adenomas have the potential for malignant transformation to ampullary carcinomas by an adenoma-to-carcinoma sequence. Thus, adequate patient selection and complete resection (R0) of non-invasive ampullary lesions either by endoscopic papillectomy (EP), surgical ampullectomy (SA), or pancreaticoduodenectomy (PD) is essential. Read More

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http://dx.doi.org/10.3389/fmed.2020.00152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218136PMC

MTA1 Promotes Hepatocellular Carcinoma Progression by Downregulation of DNA-PK-Mediated H1.2 Phosphorylation.

Front Oncol 2020 6;10:567. Epub 2020 May 6.

Department of General Surgery, The China-Japan Union Hospital, Jilin University, Changchun, China.

Global incidence and mortality associated with hepatocellular carcinoma (HCC) is steadily increasing. Metastasis-associated 1 (MTA1) can induce tumorigenesis and metastatic progression in HCC. However, the mechanistic details of MTA1-mediated regulation of HCC has not been completely defined. Read More

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http://dx.doi.org/10.3389/fonc.2020.00567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218115PMC

Bioinformatics Analysis of Domain 1 of HCV-Core Protein: Iran.

Int J Pept Res Ther 2020 20;26(1):303-320. Epub 2019 Apr 20.

Shiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, 71937 Iran.

Hepatitis C virus (HCV) infection is a serious global health problem and a cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). Bioinformatics software has been an effective tool to study the HCV genome as well as core domains. Our research was based on employing several bioinformatics software applications to find important mutations in domain 1 of core protein in Iranian HCV infected samples from 2006 to 2017, and an investigation of general properties, B-cell and T-cell epitopes, modification sites, and structure of domain 1. Read More

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http://dx.doi.org/10.1007/s10989-019-09838-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223762PMC

Lymphaticovenular Anastomosis for Treatment of Lymphedema Developed After Liver Transplantation: A Case Report.

Transplant Proc 2020 May 17. Epub 2020 May 17.

Department of Plastic and Reconstructive Surgery, Ewha Womans University Mokdong Hospital, College of Medicine, Ewha Womans University, Seoul, Republic of Korea. Electronic address:

Objective: Secondary lymphedema of the extremities usually develops well after lymph node dissection or radiation therapy in oncologic surgery. In this report, we present a case of lymphedema developed after liver transplantation and treatment by lymphaticovenular anastomosis (LVA).

Methods: A 52-year-old man was diagnosed with hepatocellular carcinoma in April 2016, and a liver transplantation was performed in June 2016. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.02.179DOI Listing

Poorly Differentiated Breast Adenocarcinoma as a Rare Cause of Right Ventricular Outflow Tract Compression: Case Report and Review of the Literature.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620923237

Department of Internal Medicine, Division of Pulmonary and Critical Care, Eastern Virginia Medical School, Norfolk, VA, USA.

Metastatic cancer that involves the structures of the heart is a rare complication and most commonly diagnosed during postmortem examination. Classically, the development of secondary tumors involves invasion of the pericardium or the myocardium and may disrupt the cardiac conduction system, causing new arrhythmias and heart failure. In this article, we present the case of a 58-year-old female with new diagnosis of ventricular bigeminy, and evidence of cardiac tamponade physiology from direct compression of the right ventricular outflow tract from high-grade carcinoma of the left breast. Read More

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http://dx.doi.org/10.1177/2324709620923237DOI Listing

Systemic therapy for advanced hepatocellular carcinoma: targeted therapies.

Chin Clin Oncol 2020 May 14. Epub 2020 May 14.

Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA.

Therapeutic options for advanced, unresectable hepatocellular carcinoma (HCC) have changed dramatically over the last 3 years. While surgical resection, orthotropic liver transplantation, and localized therapeutic options such as ablation, radiation therapy, and embolization remain therapeutics of choice in localized disease, systemic therapy is the only option in advanced, metastatic HCC. Since the United States Food and Drug Administration (US FDA) approval of sorafenib in 2008, targeted therapies such as sunitinib, tivantinib, brivanib, erlotinib, and linifanib; monoclonal antibody- bevacizumab showed no meaningful improvement in treatment of HCC. Read More

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http://dx.doi.org/10.21037/cco-20-117DOI Listing

Sorafenib Inhibits Proliferation, Migration and Invasion of Breast Cancer Cells.

Oncology 2020 May 20:1-9. Epub 2020 May 20.

Stem Cells and Cancer Biology Research Group, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India,

Introduction: Metastatic breast cancer has poor prognosis due to limited therapeutic options. Protein kinase dysregulations have a major role in breast cancer progression and metastasis. In this study, we investigated the anti-cancer activity of sorafenib, a multikinase inhibitor, which targets receptor tyrosine kinases in breast cancer. Read More

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http://dx.doi.org/10.1159/000505521DOI Listing

Establishment of rat liver cancer cell lines with different metastatic potential.

Sci Rep 2020 May 20;10(1):8329. Epub 2020 May 20.

Department of Laboratory Animal Science of Hebei Medical University, Heibei Key Laboratory of Laboratory Animals, Shijiazhuang, 050017, Hebei, China.

The gloomy outcome of liver cancer is mainly due to the high rates of metastasis and recurrence, even after curative resection for early stage liver cancer. Our study was conducted to find the animal model suitable for the study of liver cancer metastasis. In our study, two liver cancer cells were obtained from N-nitrosodiethylamine (DEN) and N-nitrosomorpholine (NMOR) induced rats, and they were cultivated, screened and cloning cultivated. Read More

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http://dx.doi.org/10.1038/s41598-020-65338-wDOI Listing

Radioiodine Retention Within Dilated Common Biliary Duct Mimicking Metastatic Thyroid Cancer Diagnosed by the Combination of SPECT/CT and MRI.

Clin Nucl Med 2020 May 19. Epub 2020 May 19.

From the Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China.

A 55-year-old woman with papillary thyroid carcinoma under total thyroidectomy and cervical lymph node dissection was referred for I radioiodine therapy. Posttherapeutic whole-body scintigraphy revealed increased focal uptake in the right upper abdomen, which localized to the region of the head of the pancreas on SPECT/CT fusion images. Further evaluation with MRI affirmed the radioiodine retention corresponded to bile duct dilation. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003054DOI Listing

Incidental Finding of Colon Carcinoma Related to High Uptake in 18F-PSMA-1007 PET.

Clin Nucl Med 2020 May 19. Epub 2020 May 19.

From the Department of Nuclear Medicine, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.

We present a 78-year-old man with suspicion of prostate cancer due to a PSA of 200 ng/mL, who underwent F-PSMA-1007 (prostate specific membrane antigen) PET/CT for primary staging. Besides heterogeneous uptake to the prostate, an increased PSMA uptake in the cecum was observed, located in the thickened cecal wall with suspicion of a secondary malignancy. Colonoscopic biopsy followed by hemicolectomy confirmed the diagnosis of colon adenocarcinoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003081DOI Listing

Immune checkpoint inhibitors in patients with recurrent hepatocellular carcinoma after liver transplantation: one case report and literature review.

Curr Cancer Drug Targets 2020 May 19. Epub 2020 May 19.

Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016. China.

Background: Immune checkpoint modulators, such as the programmed death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitor, cytotoxic T-Lymphocyte-associated antigen 4 (CTLA-4) inhibitor have been investigated with encouraging results for hepatocellular carcinoma (HCC). However, the safety of this strategy in patients with previous liver transplantation (LT) is not well studied.

Objective: To explore the safety and feasibility of immune checkpoints inhibitors in recurrent and metastatic HCC patients on a background of LT. Read More

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http://dx.doi.org/10.2174/1568009620666200520084415DOI Listing

Granulocyte colony-stimulating factor-producing squamous cell carcinoma of the tongue exhibiting characteristic fluorine-18 deoxyglucose accumulation on positron emission tomography-computed tomography: A case report.

World J Clin Cases 2020 May;8(9):1666-1673

Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8549, Japan.

Background: Granulocyte colony-stimulating factor (G-CSF) is a cytokine produced in inflammatory environments that induces differentiation and proliferation of neutrophils in bone marrow. We report a rare case of aggressive G-CSF-producing squamous cell carcinoma of the tongue exhibiting fluorine-18 deoxyglucose (FDG) accumulation in primary lesion, metastatic lymph nodes, spleen, and bone marrow on positron emission tomography-computed tomography (PET/CT).

Case Summary: We report a 58-year-old female with a rapid enlarged lingual mass with partial necrosis. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i9.1666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211540PMC

Serous Microcystic Cystadenocarcinoma of the Pancreas with Synchronous Liver Metastases: Clinical Characteristics and Management.

Cureus 2020 Apr 17;12(4):e7707. Epub 2020 Apr 17.

2nd Department of Surgery, "Aretaeio" Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, GRC.

Serous cystadenocarcinoma of the pancreas is a rare but well-established entity. The origin and evolution of this disorder remain unclear, but even metastatic cases have an excellent prognosis. These tumors are very similar to benign serous cystic neoplasms (SCNs) of the pancreas, except that they tend to be larger, are locally invasive, and present distant metastasis. Read More

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http://dx.doi.org/10.7759/cureus.7707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233488PMC

Cavitating pulmonary metastases from a renal cell carcinoma.

Clin Pract 2020 Mar 11;10(1):1234. Epub 2020 May 11.

Division of Pulmonary Diseases and Critical Care.

Cavitary lung lesions are quite common findings on chest imaging and often pose a diagnostic challenge to the clinicians. We describe a case of a 75-year-old male who presented to the emergency room with hemoptysis. Computed tomography of the chest demonstrated multiple cavitary pulmonary nodules with peripheral groundglass opacities. Read More

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http://dx.doi.org/10.4081/cp.2020.1234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232016PMC

Impact of F-FDG-PET/CT on the identification of regional lymph node metastases and delineation of the primary tumor in esophageal squamous cell carcinoma patients.

Strahlenther Onkol 2020 May 19. Epub 2020 May 19.

Department of Radiation Oncology, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Bachstraße 18, 07743, Jena, Germany.

Purpose: In patients undergoing chemoradiation for esophageal squamous cell carcinoma (ESCC), the extent of elective nodal irradiation (ENI) is still discussed controversially. This study aimed to analyze patterns of lymph node metastases and their correlation with the primary tumor using F‑fludeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans.

Methods: 102 ESCC patients with pre-treatment FDG-PET/CT scans were evaluated retrospectively. Read More

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http://dx.doi.org/10.1007/s00066-020-01630-yDOI Listing

Pathway-specific genome editing of PI3K/mTOR tumor suppressor genes reveals that PTEN loss contributes to cetuximab resistance in head and neck cancer.

Mol Cancer Ther 2020 May 19. Epub 2020 May 19.

Moores Cancer Center, University of California, San Diego

Cetuximab, a monoclonal antibody targeting EGFR, is a standard of care for the treatment for locally advanced or metastatic head and neck squamous cell carcinoma (HNSCC). However, despite overexpression of EGFR in over 90% of HNSCC lesions, most HNSCC patients fail to respond to cetuximab treatment. In addition, there are no available biomarkers to predict sensitivity or resistance to cetuximab in the clinic. Read More

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http://dx.doi.org/10.1158/1535-7163.MCT-19-1036DOI Listing

The contrasting roles of Dysferlin during tumor progression in renal cell carcinoma.

Urol Oncol 2020 May 17. Epub 2020 May 17.

Department of Urology, University Hospital Bonn, Bonn, Germany.

Background: The vesicle fusion protein Dysferlin (DYSF) is mainly known as a membrane repair protein in muscle cells. Mutations of DYSF lead to muscular dystrophies and cardiomyopathies. In contrast to other members of the Ferlin protein family, few is known about its role in cancer. Read More

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http://dx.doi.org/10.1016/j.urolonc.2020.04.021DOI Listing
May 2020
2.768 Impact Factor