63 results match your criteria Metastasizing Benign Mixed Tumor


[Hepatic metastasis of a pleomorphic adenoma].

Medicina (B Aires) 2019 ;79(1):64-66

Servicio de Cirugía General, Hospital Alemán, Buenos Aires, Argentina.

Pleomorphic adenoma is the most benign tumor of the salivary glands. It can undergo a malignant transformation to carcinoma and metastasize to distant organs, sometimes it can metastasize as a benign tumor. We present the case of an 82 years old male with hepatic lesion detected by ultrasound in routine urologic follow-up. Read More

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January 2019
4 Reads

Metastasizing uterine mullerian adenosarcoma in a young female: Diagnostic enigma.

Indian J Pathol Microbiol 2018 Jul-Sep;61(3):440-442

Department of Surgical Oncology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.

Uterine adenosarcomas are uncommon tumors. It is a biphasic tumor with both epithelial and mesenchymal component. The epithelial component is benign in nature, and the mesenchymal component is malignant. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_1_18DOI Listing
November 2018
7 Reads

Metastasizing pleomorphic adenoma in the multiple organs: A case report on FDG-PET/CT imaging.

Medicine (Baltimore) 2018 Jun;97(23):e11077

Department of Pathology, The Cancer Institute Hospital of JFCR, Tokyo, Japan.

Rationale: Pleomorphic adenoma, the most common tumor of the salivary glands, is usually benign. It is well known, however, that pleomorphic adenomas occasionally undergo malignant transformation to carcinoma ex pleomorphic adenoma and can metastasize. More rarely pleomorphic adenomas can metastasize without histological malignant transformation. Read More

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http://dx.doi.org/10.1097/MD.0000000000011077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999481PMC
June 2018
5 Reads

Metastasising Pleomorphic Salivary Adenoma: A Rare Case Report of a Massive Untreated Minor Salivary Gland Pleomorphic Adenoma with Concurrent Ipsilateral Cervical Node Metastases.

Head Neck Pathol 2018 May 3. Epub 2018 May 3.

OMFS Consultant, St John's Hospital, Livingston, Scotland, UK.

Salivary gland tumours constitute approximately 1-5% of all human neoplasms. Pleomorphic adenoma (PA) is the commonest benign neoplasm affecting the parotid gland most often (> 75%), followed by the submandibular gland (13%), then the palate (9%). Metastasising pleomorphic adenoma (MPA) is extremely rare. Read More

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http://dx.doi.org/10.1007/s12105-018-0920-8DOI Listing
May 2018
15 Reads

Metastasizing pleomorphic adenoma of the parotid gland.

Ecancermedicalscience 2017 15;11:758. Epub 2017 Aug 15.

Hospital de Clinicas, Piso 2, Consultorio 228, San Bernardino, Caracas, 1010 584248518639/2125086228, Venezuela.

Salivary gland tumours are estimated to represent approximately 3% of all head and neck tumours. About 70-80% of these neoplasms occur in the major salivary glands, with the parotid gland being the most commonly affected site. The metastasizing pleomorphic adenoma (MPA) has histological characteristics of pleomorphic adenoma, but it has the capacity to generate local recurrences and distant metastases (mainly bones, lungs, and lymph nodes). Read More

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http://dx.doi.org/10.3332/ecancer.2017.758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574653PMC
August 2017
5 Reads

Metastasizing Pleomorphic Adenoma Case Report and Review of the Literature.

Head Neck Pathol 2017 Dec 25;11(4):487-493. Epub 2017 May 25.

Department of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, 355 Squire Hall, Buffalo, NY, 14214, USA.

Pleomorphic adenoma (PA) is by far the most common salivary gland tumor. It is well known that PA can undergo malignant transformation. However, in rare occasions it can metastasize preserving its benign phenotype. Read More

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http://dx.doi.org/10.1007/s12105-017-0815-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677069PMC
December 2017
35 Reads

Benign metastasizing pleomorphic adenoma in liver mimicking synchronic metastatic disease from colorectal cancer: a case report with emphasis on imaging findings.

Acta Radiol Open 2015 Aug 7;4(8):2058460115594199. Epub 2015 Aug 7.

Department of Radiology, Oslo University Hospital, Oslo, Norway.

Pleomorphic adenoma of the parotid gland with metastases to the liver is a rare etiology of focal liver lesions, and there are no described pathognomonic imaging features. We report a patient who presented with a newly diagnosed rectal cancer and multiple cystic liver lesions suspicious of mucinous synchronous liver metastases. Following chemotherapy no reduction in the number or size of the liver lesions was observed. Read More

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http://dx.doi.org/10.1177/2058460115594199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548729PMC
August 2015
9 Reads

Metastasising pleomorphic adenoma: Systematic review.

Int J Surg 2015 Jul 6;19:137-45. Epub 2015 May 6.

Department of General Surgery, Royal Surrey County Hospital, UK.

Background: Pleomorphic adenoma (PA) is the commonest benign neoplasm of salivary glands.(1) PA can undergo malignant transformation to ex-pleomorphic adenoma (2,3) but rarely, can metastasise without malignant transformation.(4,5) Metastasising pleomorphic adenoma (MPA) is a rare malignant tumour which, histologically, is indistinguishable from PA yet produces secondary tumours in distant sites. Read More

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http://dx.doi.org/10.1016/j.ijsu.2015.04.084DOI Listing
July 2015
6 Reads

Carcinoma ex pleomorphic adenoma: Diagnostic dilemma and treatment protocol.

Indian J Dent 2014 Jul;5(3):157-60

Department of Oral and Maxillofacial Surgery, Vokkaligara Sangha Dental College and Hospital and Research Centre, KR Road, VV Puram, Bangalore, Karnataka, India.

Carcinoma ex pleomorphic adenoma (CXPA) is a carcinoma arising from a primary or recurrent benign pleomorphic adenoma. It often poses a diagnostic challenge to clinicians and pathologists. The entity is difficult to diagnose preoperatively. Read More

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http://dx.doi.org/10.4103/0975-962X.140840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213878PMC
July 2014
5 Reads
2 Citations

Metastasizing pleomorphic adenoma of the submandibular gland: a case report.

Pathologica 2014 Mar;106(1):29-31

Pleomorphic adenoma (PA), originally called mixed tumour, is the most common neoplasm of the salivary glands. It is usually a benign, slow-growing and well-circumscribed tumour. However, PA may occasionally give rise to metastases that usually occur after a previous recurrence. Read More

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March 2014
4 Reads

Metastasizing "benign" pleomorphic salivary adenoma: a dramatic case-report and literature review.

J Craniomaxillofac Surg 2014 Dec 14;42(8):1562-5. Epub 2014 Jan 14.

Maxillofacial Surgery Unit, Alma Mater Studiorum University of Bologna, Bologna, Italy.

Pleomorphic salivary adenomas are the most common benign neoplasms affecting the salivary glands. Very occasionally however, metastatic lesions are identified in patients with a history of PSA, which, on detailed pathological evaluation, are found to exhibit all the histological hallmarks of the preceding benign lesions. Diagnosis of benign metastasizing pleomorphic adenoma of the salivary gland is extremely rare and still under debate. Read More

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http://dx.doi.org/10.1016/j.jcms.2014.01.014DOI Listing
December 2014
6 Reads

A case of metastasizing pleomorphic adenoma in the maxillary bone appearing twenty years after initial resection of pleomorphic adenoma of the hard palate.

Pathol Int 2013 Sep 28;63(9):463-8. Epub 2013 Aug 28.

Department of Pathology, Kurume University School of Medicine, Kurume, Japan.

Metastasizing pleomorphic adenoma (MPA) is the inexplicable metastasis of a histologically benign pleomorphic adenoma (PA). Approximately 50 cases have been reported. A 62-year-old woman noticed pain in the upper molar area. Read More

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http://dx.doi.org/10.1111/pin.12087DOI Listing
September 2013
6 Reads

Metastasizing "benign" cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases.

Am J Surg Pathol 2013 Apr;37(4):484-95

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Cutaneous fibrous histiocytoma (FH) is considered a benign tumor; however, certain types of FH have been shown to have a tendency for local recurrence, and there are rare reported cases of metastasis. In this study, 16 cases of morphologically benign FH with locoregional or distant metastasis were identified in consult files. Pathologic features of primary, recurrent, and metastatic tumors, as well as clinical outcome, were evaluated. Read More

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http://dx.doi.org/10.1097/PAS.0b013e31827070d4DOI Listing
April 2013
4 Reads

Benign metastasizing pleomorphic adenoma presenting as a solitary kidney mass: imaging features.

Urology 2012 Aug 27;80(2):e17-8. Epub 2012 Jun 27.

Division of Abdominal Imaging and Intervention, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Benign metastasizing pleomorphic adenoma is a rare condition that occurs in patients with a prior history of pleomorphic adenoma of the salivary glands. Metastases to the kidney are extremely rare, and, to the best of our knowledge, their imaging appearance on multiple cross-sectional imaging modalities has not been described. We present a solitary metastasis to the kidney in a 40-year-old woman. Read More

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http://dx.doi.org/10.1016/j.urology.2012.04.055DOI Listing
August 2012
9 Reads

Benign pleomorphic adenoma of the soft palate metastasizing to the sphenoid sinus.

Clin Exp Otorhinolaryngol 2010 Sep 17;3(3):172-5. Epub 2010 Sep 17.

Department of Otorhinolaryngology-Head and Neck Surgery, Yeungnam University College of Medicine, Daegu, Korea.

A benign pleomorphic adenoma is the most common tumor of the salivary glands. This tumor has the potential to metastasize to bone, the head and neck region, visceral organs and skin. Although there a few reports about a benign pleomorphic adenoma metastasizing to the maxillary sinus in the paranasal sinuses, there are no reports about a metastatic benign pleomorphic adenoma in the sphenoid sinus. Read More

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http://dx.doi.org/10.3342/ceo.2010.3.3.172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958505PMC
September 2010
5 Reads

A hepatic metastasis from pleomorphic adenoma of salivary gland: an unusual presentation.

Hepatogastroenterology 2010 Mar-Apr;57(98):330-3

Nazih Zuhdi Transplant Institute, Integris Baptist Medical Center, 3300 NW Expressway, Oklahoma City, Oklahoma 73112, USA.

Metastasizing pleomorphic adenoma (PA) is a rare condition displaying benign histological features as of PA in the metastatic lesion. The present study report a case of 46 years old male presented with space occupying lesion in the right lobe of liver. Patient underwent extended right hepatectomy for space occupying lesion in liver and the histological features were suggestive of metastatic benign pleomorphic adenoma. Read More

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August 2010
5 Reads

Expression of hormonal receptor in patients with metastasizing pleomorphic adenoma of the major salivary gland; a clinicopathological report of three cases.

J Med Assoc Thai 2009 Sep;92(9):1250-5

Department of Pathology, Faculty ofMedicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Metastasizing pleomorphic adenoma is an uncommon malignant tumor of the salivary gland demonstrating benign epithelial and modified myoepithelial elements intermingling with tissue of mucoid, myxoid, or chondroid appearance that inexplicably manifests local or distant metastasis.

Objective: To determine the expression of hormonal receptor in the patients with metastasizing pleomorphic adenoma of the major salivary gland.

Material And Method: Medical records, clinical and pathologic findings of three patients who were diagnosed as metastasizing pleomorphic adenoma were reviewed. Read More

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September 2009
7 Reads

An intracapsular carcinoma ex pleomorphic adenoma with lung metastases composed exclusively of benign elements: histological evidence of a continuum between metastasizing pleomorphic adenoma and carcinoma ex pleomorphic adenoma.

Pathol Res Pract 2010 Jul 7;206(7):480-3. Epub 2009 Aug 7.

Department of Cellular Pathology, Birmingham Heartlands Hospital, Bordesley Green, B9 5SS, UK.

Malignant mixed tumors of the salivary glands, encompassing carcinoma ex pleomorphic adenoma (ca ex PA), carcinosarcoma and metastasizing pleomorphic adenoma (mPA), are rare neoplasms. Ca ex PA arises in a pre-existing pleomorphic adenoma (PA). When the malignant component does not breach the capsule of the parent PA, the lesion is termed intracapsular ca ex PA, a neoplasm which is thought to have no metastatic potential. Read More

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http://dx.doi.org/10.1016/j.prp.2009.07.008DOI Listing
July 2010
5 Reads

Fine-needle aspiration (FNA) and pleural fluid cytology diagnosis of benign metastasizing pleomorphic adenoma of the parotid gland in the lung: a case report and review of literature.

Diagn Cytopathol 2009 Nov;37(11):828-31

Department of Pathology, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, Florida 33136, USA.

Lesions that contain abundant benign myoepithelial cells, including pleomorphic adenomas of salivary gland origin, may present a diagnostic challenge in fine-needle aspiration (FNA) specimens. Benign metastasizing pleomorphic adenoma is a rare neoplasm, in which the benign appearing pleomorphic adenoma, without any histological evidence of malignancy, metastasizes to distant sites including lung. In the absence of clinical history of a pre-existing myoepithelial neoplasm, the presence of myoepithelial cells in the lung or any other organs besides salivary glands may create diagnostic difficulty. Read More

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http://dx.doi.org/10.1002/dc.21123DOI Listing
November 2009
6 Reads

Spectrum of malignancy in mixed tumors of salivary gland: a morphological and immunohistochemical review of 23 cases.

Indian J Pathol Microbiol 2009 Apr-Jun;52(2):150-4

Section of Histopathology, Aga Khan University, Karachi, Pakistan.

Malignancy arising in mixed tumors of the salivary gland is a distinct entity that can occur sporadically or in association with a background of pleomorphic adenoma. Carcinoma arising with a background of pleomorphic adenoma is well documented. However, there are rare occurrences of aggressive de novo carcinosarcomas of the parotid that have been reported. Read More

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May 2009
17 Reads
1 Citation
0.642 Impact Factor

Metastasizing pleomorphic adenoma presenting as an asymptomatic kidney tumor twenty-nine years after parotidectomy - urological viewpoint and overview of the literature to date.

Rare Tumors 2009 Dec 28;1(2):e54. Epub 2009 Dec 28.

Department of Urology, and.

Pleomorphic adenomas (benign mixed tumors) are the most common tumors of glandular origin in the head and neck and are one of the few benign neoplasms that can undergo malignant transformation.(1) Mixed tumors that are seemingly benign at the microscopic level but metastasize have been termed metastasizing mixed tumors (MZMTs). The entity of metastasizing benign mixed tumors has been reported since the early 1940s, with up to approximately 50 cases described in the literature to date. Read More

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http://dx.doi.org/10.4081/rt.2009.e54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994456PMC
December 2009
19 Reads

Pleomorphic adenoma of the parotid gland metastasizing to the scapular region: a case report.

Acta Cytol 2008 Nov-Dec;52(6):733-5

Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Background: Metastasizing pleomorphic adenoma (MPA) is a rare, incompletely understood enigmatic entity having the histologic appearance of benign pleomorphic adenoma and clinically malignant behavior. We report a case of MPA of the parotid gland that metastasized to the scapular region 6 years after the appearance of the primary lesion in the left parotid gland.

Case: A 35-year-old woman presented with a palpable soft to firm mass of 3-cm diameter in the left scapular region that was slightly mobile over the underlying structures and a small swelling at the operated site of the parotid region. Read More

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http://dx.doi.org/10.1159/000325632DOI Listing
January 2009
21 Reads
1 Citation
1.562 Impact Factor

Metastasizing pleomorphic adenoma of the salivary gland.

Arch Pathol Lab Med 2008 Sep;132(9):1445-7

Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.

Metastasizing pleomorphic adenoma of salivary glands is a group of rare tumors that are histologically identical to benign mixed tumors and that inexplicably metastasize. A review of the literature revealed that it usually occurs after multiple local recurrences, and the interval between diagnosis of primary pleomorphic adenoma and metastases ranges between 3 and 52 years. The most common site for metastasis is bone, followed by the head and neck and lung. Read More

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http://dx.doi.org/10.1043/1543-2165(2008)132[1445:MPAOTS]2.0.CO;2DOI Listing
September 2008
4 Reads

[Carcinoma ex pleomorphic adenoma of major salivary glands--a clinicopathologic review].

Otolaryngol Pol 2007 ;61(5):687-93

Katedra i Klinika Chorób Uszu, Nosa, Gardła i Krtani AM w Gdańsku.

Background: Pleomorphic adenoma (PA) is the most common neoplasm of the major salivary glands. There are three subtypes of malignant PA: carcinoma ex pleomorphic adenoma (CXPA); carcinosarcoma (true malignant mixed tumor) and metastasizing pleomorphic adenoma. The most common subtype of malignant PA is CXPA which develops in primary or recurrent PA. Read More

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http://dx.doi.org/10.1016/S0030-6657(07)70507-3DOI Listing
August 2008
6 Reads

Multiple pulmonary metastases from benign pleomorphic adenoma.

Asian Cardiovasc Thorac Ann 2008 Jan;16(1):62-4

Division of Cardiothoracic Surgery, Department of Surgery, University of Hong Kong Medical Center, Grantham Hospital, Hong Kong, China.

Metastasizing pleomorphic adenoma is a rare condition of metastasis from a histologically benign salivary gland tumor. We report a case of metastasizing pleomorphic adenoma presenting with multiple bilateral lung metastases, and discuss the clinical aspects of this disease. Read More

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http://journals.sagepub.com/doi/10.1177/021849230801600116
Publisher Site
http://dx.doi.org/10.1177/021849230801600116DOI Listing
January 2008
6 Reads

[Metastasizing pleomorphic adenoma of the submandibular gland: a case report].

Hua Xi Kou Qiang Yi Xue Za Zhi 2007 Jun;25(3):307-9

Dept. of Pathology, West China College of Stomatology, Sichuan University, Chengdu 610041, China.)

Metastasizing pleomorphic adenomas without histological evidence of malignancy have rarely been reported. A case of 30-year-old woman with a mass which showed a benign pleomorphic adenoma appearanced histologically in the left submandibular gland and right supercollarbone respectively was described. Eight years ago, the patient suffered from pleomorphic adenoma of the left submandibular gland. Read More

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June 2007
5 Reads

A case of pleomorphic adenoma of the parotid gland metastasizing to a mediastinal lymph node.

Am J Otolaryngol 2007 Mar-Apr;28(2):130-3

Department of Otolaryngology-Head and Neck Surgery, Beth Israel Medical Center, New York, NY 10467, USA.

Objective: Pleomorphic adenomas are the most common salivary gland tumors and are typically cured with complete surgical excision. There are rare reports, however, in which these histologically benign tumors have inexplicably metastasized to distant sites. We present a case of a patient who presented, 27 years after excision of a parotid pleomorphic adenoma, with a recurrence in the parotid bed and a mediastinal metastasis. Read More

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http://dx.doi.org/10.1016/j.amjoto.2006.07.002DOI Listing
May 2007
12 Reads

Metastasizing pleomorphic salivary adenoma.

Arch Otolaryngol Head Neck Surg 2006 Jul;132(7):788-93

Department of Otolaryngology-Head and Neck Surgery, Charing Cross Hospital, London, England.

Objective: To address questions about the etiology, behavior, optimal treatment, and prognosis of metastasizing pleomorphic adenoma (MPA), we undertook a review of the literature (1953-2005) and constructed a virtual series of all identified cases of MPA, metastatic lesions that are very occasionally identified in patients with a history of pleomorphic salivary adenoma and, on detailed pathological evaluation, found to exhibit all the histological hallmarks of the preceding benign lesions.

Data Sources: A review of the English-language literature between 1953 and 2005 using MEDLINE, secondary references identified from bibliographies of pertinent articles, and a further case from one of our institutions.

Data Synthesis: A virtual case series was constructed and quantitatively analyzed. Read More

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http://dx.doi.org/10.1001/archotol.132.7.788DOI Listing
July 2006
5 Reads

Sentinel lymph node biopsy in patients with "atypical Spitz tumors." A report on 12 cases.

Hum Pathol 2006 Jul 19;37(7):816-23. Epub 2006 May 19.

Department of Anatomic Pathology, Dermatopathology Section, S. M. Annunziata Hospital, Florence, Italy.

The distinction between Spitz nevus and melanoma is currently possible, applying a set of definite histological criteria. However, in certain lesions deviating from the stereotypical morphology of classic Spitz nevi ("atypical Spitz tumors"), the differentiation between benign and malignant cases appears problematic because objective criteria for a reliable diagnosis are lacking. We report the clinicopathologic findings of 12 patients with atypical Spitz tumors, who underwent sentinel node biopsy. Read More

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http://dx.doi.org/10.1016/j.humpath.2006.02.001DOI Listing
July 2006
4 Reads

Metastasizing mixed tumour of the parotid gland presenting as multiple lung metastases.

J Laryngol Otol 2004 Sep;118(9):724-6

Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan.

Metastasis is a feature of malignant neoplasms. Although rare, metastasizing pathologically benign mixed tumour has been reported. This report describes a 33-year-old woman with multiple lung metastases from mixed tumour. Read More

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http://dx.doi.org/10.1258/0022215042244750DOI Listing
September 2004
3 Reads

Pleomorphic adenoma and carcinoma ex pleomorphic adenoma: immunohistochemical demonstration of the association between tenascin expression and malignancy.

Histopathology 2004 Aug;45(2):187-92

Serviço de Anatomia Patológica, Instituto Português de Oncologia de Francisco Gentil, Lisboa, Portugal.

Aims: To investigate tenascin expression in salivary gland tumours. Tenascin is a matricellular protein that has been studied in several tumour types. Its expression has been correlated with tumour morphogenesis as well as with local invasiveness and tumour metastatic behaviour. Read More

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http://dx.doi.org/10.1111/j.1365-2559.2004.01924.xDOI Listing
August 2004
4 Reads

[Malignant mixed tumor].

Gan To Kagaku Ryoho 2004 Mar;31(3):314-7

Dept. of Otorhinolarygology, Chiba National Hospital, 4-1-2 Tsubakimori, Chuo-ku, Chiba 260-8606, Japan.

The term "malignant mixed tumor" is usually synonymous with "carcinoma in pleomorphic adenoma," a secondary carcinoma developing in pre-existing pleomorphic adenoma. However, it sometimes indicates a group of tumors consisting of carcinoma in pleomorphic adenoma, carcinosarcoma (true malignant mixed tumor) and metastasizing benign mixed tumor, the latter 2 being the most infrequent. According to the data of the Japanese committee on TNM classification for salivary gland carcinomas, carcinoma in pleomorphic adenoma accounted for about 10% of all salivary gland carcinomas, both in the parotid and submandibular glands. Read More

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March 2004
9 Reads

Carcinosarcoma of the submandibular gland: an autopsy case.

Auris Nasus Larynx 2003 Dec;30(4):439-42

Department of Otolaryngology, Head and Neck Surgery, Shiga University of Medical Science, Seta Tsukinowa, Ohtsu, 520-2192, Shiga, Japan.

Malignant mixed tumors of salivary glands are classified as three types:carcinoma arising in a pleomorphic adenoma, the most common; benign metastasizing pleomorphic adenoma; and carcinosarcoma (true malignant mixed tumor), which is very rare [Ann. Otol. Rhinol. Read More

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December 2003
6 Reads

Benign metastasizing pleomorphic adenoma of the parotid gland: a clinicopathologic puzzle.

Head Neck 2003 Dec;25(12):1071-6

Department of Otolaryngology-Head and Neck Surgery, University of Padua, Via Giustiani 2, Padua, Italy.

Background: Pleomorphic adenoma constitutes the most common benign parotid gland tumor. Local recurrence after surgical treatment (lateral or total parotidectomy) has been described in 1% to 5% of cases. Malignant degeneration has been reported in 2% to 9% of cases of pleomorphic adenoma of salivary gland origin. Read More

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http://dx.doi.org/10.1002/hed.10319DOI Listing
December 2003
16 Reads

Endometrial stromal sarcomas with unusual histologic features: a report of 24 primary and metastatic tumors emphasizing fibroblastic and smooth muscle differentiation.

Am J Surg Pathol 2002 Sep;26(9):1142-50

Department of Pathology, Memorial Sloan-Kettering Cancer Center and Weill Medical College of Cornell University, New York, NY 10021, USA.

We report the clinicopathologic features of 24 uterine primary and metastatic endometrial stromal sarcomas with fibromyxoid features (ESS-F) and smooth muscle differentiation (ESS-SM) (endometrial stromal sarcoma variants). Two groups of tumors were retrieved from the surgical pathology files at Memorial Sloan-Kettering Cancer Center: 1) gynecologic mesenchymal neoplasms with striking smooth muscle or fibroblastic differentiation that did not meet the clinical or histologic criteria for leiomyosarcoma or other established neoplasms containing smooth muscle; and 2) metastatic lesions showing ovoid and spindle cell morphology, involving lung, originally diagnosed as low-grade leiomyosarcoma, low-grade smooth muscle neoplasm, intravenous leiomyomatosis, fibrous hamartoma, and benign metastasizing leiomyoma. We identified 12 patients with 30 tumors; 24 were available for review. Read More

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September 2002
10 Reads

Unusual presentations of uncommon tumors: case 1. Benign metastasizing pleomorphic adenoma.

J Clin Oncol 2002 May;20(9):2400-3

University of Hawaii, Honolulu, HI, USA.

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http://dx.doi.org/10.1200/JCO.2002.20.9.2400DOI Listing
May 2002
9 Reads

First insights into the molecular basis of pleomorphic adenomas of the salivary glands.

Adv Dent Res 2000 Dec;14:81-3

Laboratory for Molecular Oncology, Center for Human Genetics, University of Leuven & Flanders Interuniversity Institute for Biotechnology, Belgium.

Pleomorphic adenoma, or mixed tumor of the salivary glands, is a benign tumor originating from the major and minor salivary glands. Eighty-five percent of these tumors are found in the parotid gland, 10% in the minor (sublingual) salivary glands, and 5% in the submandibular gland. It is the most common type of salivary gland tumor, accounting for almost 50% of all neoplasms in these organs. Read More

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http://dx.doi.org/10.1177/08959374000140011301DOI Listing
December 2000
4 Reads

Metastasizing mixed tumor of the parotid: initial presentation as a solitary kidney tumor and ultimate carcinomatous transformation at the primary site.

Am J Surg Pathol 2000 Aug;24(8):1159-64

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

Benign mixed tumors of the salivary glands are generally regarded as indolent and harmless neoplasms. A subset of benign mixed tumors, however, can undergo carcinomatous transformation (that is, carcinoma ex-mixed tumor). Even more rarely, a mixed tumor that is seemingly benign at the microscopic level will metastasize like a true carcinoma (that is, metastasizing mixed tumor [MZMT]). Read More

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August 2000
2 Reads

Laminin and collagen IV in pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: an immunohistochemical study.

Hum Pathol 1999 Aug;30(8):964-9

Departamento de Patologia Morfológica, Instituto Português de Oncologia de Francisco Gentil, Lisboa Codex.

Laminin and collagen have been studied in several tumor types and their immunomorphological expression correlated with tumor morphogenesis, local invasiveness, and metastatic behavior. In a series of 53 cases of pleomorphic adenomas (PA) and 16 cases of carcinomas ex-pleomorphic adenoma (Ca ex-PA), we investigated by immunohistochemistry the distribution pattern of laminin (lam) and collagen IV (col IV) at the basement membrane (BM) and the interstitial compartments, and their potential relationship with the metastatic behavior of Ca ex-PA. At the BM compartment, lam and col IV were expressed in 37 and 41 of all cases, respectively. Read More

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August 1999
6 Reads

A case of metastasizing pleomorphic adenoma.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999 Mar;87(3):341-5

Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Otago, New Zealand.

The pleomorphic adenoma is the most common benign salivary neoplasm. A case is presented in which a palatal pleomorphic adenoma seeded a metastasis in the medullary cavity of the anterior maxilla, apparently by hematogenous spread after surgical manipulation. Read More

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March 1999
3 Reads

Fine-needle aspiration findings in patients with polymorphous low grade adenocarcinoma of the salivary glands.

Cancer 1999 Feb;87(1):31-6

Department of Pathology, University of Texas, Southwestern Medical Center at Dallas, 75235-9073, USA.

Background: Polymorphous low grade adenocarcinoma of the salivary glands (PLAC) is a low grade neoplasm that predominantly occurs in the minor salivary glands. In this site it is amenable to biopsy and histologic diagnosis. However, experience with fine-needle aspiration (FNA) biopsy findings in these tumors is limited. Read More

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February 1999
5 Reads

[A case of very late malignant degeneration of pleomorphic adenoma].

Ann Otolaryngol Chir Cervicofac 1998 Dec;115(6):373-7

Service de Chirurgie Maxillo-Faciale, Plastique et Reconstructrice, Clinique Ste Elisabeth, Namur, Belgique.

Incomplete excision of a pleomorphic adenoma exposes to a high risk of recurrence and tumor spread, making secondary surgery more difficult or a malignant transformation with a poor vital prognosis likely. Three histological types of pleomorphic adenomas can be observed when the tumor undergoes a transformation, namely the carcinoma ex-pleomorphic adenoma, the true malignant mixed tumor and the benign metastasizing mixed tumour. Read More

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December 1998
5 Reads

Metastasizing mixed tumor of the parotid gland: a rare tumor with unusually rapid progression in a cardiac transplant recipient.

Mod Pathol 1998 Nov;11(11):1142-5

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

We report the case of a 69-year-old man who had a mixed tumor (pleomorphic adenoma) removed from his parotid gland 3 years after orthotopic heart transplantation. Two years later, he presented with widely metastatic mixed tumor, which resulted in his death within 6 months. Metastatic mixed tumor is histologically identical to a benign mixed tumor, but it inexplicably metastasizes. Read More

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November 1998
3 Reads

A case of pleomorphic adenoma of the lung with multiple distant metastases--observations on its oncogene and tumor suppressor gene expression.

Anticancer Res 1998 May-Jun;18(3B):2015 -20

Third Department of Internal Medicine, University of Tokushima School of Medicine, Japan.

Pleomorphic adenoma of the lung is a rare neoplasm. Here we describe the first report on oncogenes and tumor suppressor genes in metastasizing pleomorphic adenoma of the lung. A 48-year-old Japanese woman presented with metastasizing pleomorphic adenoma in which both the primary lung tumor and metastatic lesions were composed of benign pleomorphic structures. Read More

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July 1998
3 Reads

Unbalanced chromosomal rearrangements in a metastasizing salivary gland tumor with benign histology.

Cancer Genet Cytogenet 1998 Apr;102(1):59-64

Department of Clinical Genetics, University Hospital, Lund, Sweden.

Benign metastasizing pleomorphic adenoma (BMPA) is a rare tumor of the salivary glands. Despite benign histopathologic features, it can metastasize and is sometimes lethal. No chromosomal data have been reported for this tumor type. Read More

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April 1998
3 Reads

Carcinomatous change in the cranial metastasis from a metastasizing mixed tumor of the salivary gland--case report.

Neurol Med Chir (Tokyo) 1997 Jul;37(7):546-50

Department of Neurosurgery, Iwate Prefectural Central Hospital, Morioka.

A 57-year-old female who had had a mixed tumor of the submandibular gland for 30 years presented with a cranial metastasis in the ipsilateral occipital region. Detailed histological examinations of the primary tumor failed to detect any carcinomatous component. In contrast, the metastasis contained a carcinomatous component. Read More

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July 1997
4 Reads

[Metastasizing pleomorphic adenoma of the parotid. Apropos of a case].

Arch Anat Cytol Pathol 1996 ;44(5-6):259-62

Service d'Anatomie et de Cytologie Pathologiques A, CHRU de Lille, Paris.

A case of metastasizing pleomorphic adenoma of the parotid in which both the primary tumor and metastasis were composed of benign pleomorphic structures is reported in a 55 year-old white woman. The pulmonary metastasis developed nine years after excision of the primary tumor without local recurrence. No mitotic activity or infiltrative growth pattern were present in the primary tumor. Read More

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November 1997
3 Reads

[Metastasizing pleomorphic adenomas. Clinical and cytometric analysis].

Rev Stomatol Chir Maxillofac 1996 ;97(1):26-31

Service de Chirurgie Orale et Maxillofaciale, Université d'Oviedo, Hôpital Central Universitaire des Asturies, Espagne.

Metastasizing pleomorphic adenoma is a rare lesion, histologically benign but with a malignant clinical behaviour. Two cases are reported with a flow cytometric study. Recurrent adenoma and its metastasis were aneuploid in one case. Read More

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June 1996
6 Reads

Benign metastasizing pleomorphic adenoma.

Otolaryngol Head Neck Surg 1995 Apr;112(4):612-5

Department of Otolaryngology-Head and Neck Surgery, Lahey Clinic, Burlington, Massachusetts, USA.

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http://dx.doi.org/10.1177/019459989511200420DOI Listing
April 1995
4 Reads

"Benign" metastasizing pleomorphic adenoma. A case report and review of literature.

Clin Orthop Relat Res 1994 Nov(308):192-8

Department of Orthopaedics, Rush Presbyterian St. Luke's Medical Center, Chicago, IL.

A case of a 34-year-old man with a pathologic fracture through a lytic lesion in the left glenoid is presented. The results of a needle biopsy of the lesion showed a benign pleomorphic adenoma. Sixteen years previously, the patient had a pleomorphic adenoma of the parotid gland. Read More

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November 1994
3 Reads