5,161 results match your criteria Metastasizing Benign Mixed Tumor


Metastatic inflammatory myofibroblastic tumor of the bladder.

Urol Case Rep 2019 Mar 15;23:10-12. Epub 2018 Nov 15.

Department of Surgery - Division of Urology, 1 Hospital Drive, MC 301E, Columbia, MO, 65212, USA.

A 61-year-old male presented with gross hematuria and transurethral resection of bladder tumor revealed inflammatory myofibroblastic tumor (IMT). Due to extent of disease leading to ureteral obstruction and hydronephrosis, radical cystectomy (RC) with ileal conduit urinary diversion was performed. Five months after RC, the patient presented with decreased urine output. Read More

View Article

Cost-effectiveness analyses and cost analyses in castration-resistant prostate cancer: A systematic review.

PLoS One 2018 5;13(12):e0208063. Epub 2018 Dec 5.

Department of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Treatment of metastatic prostate cancer is associated with high personal and economic burden. Recently, new treatment options for castration-resistant prostate cancer became available with promising survival advantages. However, cost-effectiveness of those new treatment options is sometimes ambiguous or given only under certain circumstances. Read More

View Article
December 2018
1 Read

Benign Metastasizing Leiomyoma of the Uterus: Rare Manifestation of a Frequent Pathology.

Case Rep Obstet Gynecol 2018 30;2018:5067276. Epub 2018 Oct 30.

Department of Gynecology, Francisco Gentil Portuguese Oncology Institute, Porto, Portugal.

Benign Metastasizing Leiomyoma (BML) is a rare condition with few cases reported in the literature. It is usually incidentally diagnosed several years after a primary gynecological surgery for uterine leiomyoma. Differential diagnosis of BML is complex requiring an extensive work-up and exclusion of malignancy. Read More

View Article
October 2018

Coexistence of duodenum derived aggressive fibromatosis and paraduodenal hydatid cyst: A case report and review of literature.

World J Gastrointest Surg 2018 Nov;10(8):90-94

Department of Pathology, Inonu University Faculty of Medicine, Malatya 244280, Turkey.

Intra-abdominal aggressive fibromatosis is a locally aggressive tumor mostly originating from the mesentery or retroperitoneal space, infiltrating adjacent tissues, and very rarely metastasizing to distant organs. There are only two case reports in the English language literature where intra-abdominal aggressive fibromatosis originated from the intestinal wall. In this study, we aimed to report a case of aggressive fibromatosis originating from the muscularis propria layer of the duodenum and invading pancreas. Read More

View Article
November 2018

Association of Target Therapy Gene Expression with Metastasizing of Clear-Cell Renal Cell Carcinoma.

Bull Exp Biol Med 2018 Dec 28;166(2):257-259. Epub 2018 Nov 28.

Research Center for Medical Genetics, Moscow, Russia.

We analyzed association of the levels of VEGFA, RAF1, and mTOR gene expression in the tissue of clear-cell renal cell carcinoma (ccRCC) with tumor metastasizing. Significant association with metastases was found only for VEGFA gene: OR=6.641, 95%CI=2. Read More

View Article
December 2018
1 Read

Sentinel lymph node imaging in urologic oncology.

Transl Androl Urol 2018 Oct;7(5):887-902

Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Lymph node (LN) metastases in urological malignancies correlate with poor oncological outcomes. Accurate LN staging is of great importance since patients can benefit from an optimal staging, accordingly aligned therapy and more radical treatments. Current conventional cross-sectional imaging modalities [e. Read More

View Article
October 2018
9 Reads

"Tiny Tiny Little Nothings": Minimization and Reassurance in the Face of Cancer.

Authors:
Wayne A Beach

Health Commun 2018 Nov 19:1-14. Epub 2018 Nov 19.

a School of Communication, Center for Communication, Health, & the Public Good, SDSU/UCSD Joint Doctoral Program in Public Health , San Diego State University.

Drawing from a sub-sample of video recorded and transcribed oncology interviews, Conversation Analysis is used to examine moments when cancer is portrayed as absent or minimally present but not dangerously invasive. Though cancer patients and their doctors invest considerable efforts pursuing life-affirming and hopeful possibilities advancing the quality of living and healing outcomes, little is known about how"good news" and thus hopeful social actions get organized. An interactional practice is identified for depicting tumor sizes as small or shrinking - a displayed preference to tumors that are large, growing, and spreading (i. Read More

View Article
November 2018
1 Read

Cutaneous squamous cell carcinoma metastasis to the parotid region lymph nodes.

Laryngoscope 2018 Nov 16. Epub 2018 Nov 16.

Department of Clinical Sciences, Simmons Comprehensive Cancer Center , University of Texas Southwestern Medical Center, Dallas, Texas, U.S.A.

Objective: To determine the effect on survival of periauricular region cutaneous squamous cell carcinomas (cSCC) metastasizing to parotid region and cervical lymph nodes.

Methods: From May 1995 to October 2013, consecutive patients with cSCC undergoing parotidectomy/neck dissection ≥ 18 years without distant metastasis were included. Demographic, clinical, and pathologic data were analyzed. Read More

View Article
November 2018
1 Read

Loss of ATRX/DAXX expression and alternative lengthening of telomeres in uterine leiomyomas.

Cancer 2018 Nov 13. Epub 2018 Nov 13.

Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.

Background: Uterine leiomyomas (ULs) are the most common gynecologic tumors and affect 3 of every 4 women by the age of 50 years. The majority of ULs are classified as conventional tumors, whereas 10% represent various histopathological subtypes with features that mimic malignancy. These subtypes include cellular and mitotically active ULs and ULs with bizarre nuclei. Read More

View Article
November 2018
4 Reads

Mechanically stimulated osteocytes reduce the bone-metastatic potential of breast cancer cells in vitro by signaling through endothelial cells.

J Cell Biochem 2018 Nov 11. Epub 2018 Nov 11.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

Bone metastases occur in 65% to 75% of patients with advanced breast cancer and significantly worsen their survival and quality of life. We previously showed that conditioned medium (CM) from osteocytes stimulated with oscillatory fluid flow, mimicking bone mechanical loading during routine physical activities, reduced the transendothelial migration of breast cancer cells. Endothelial cells are situated at an ideal location to mediate signals between osteocytes in the bone matrix and metastasizing cancer cells in the blood vessels. Read More

View Article
November 2018
3 Reads

Axillary lymph node metastasis in second oropharyngeal cancer.

J Stomatol Oral Maxillofac Surg 2018 Nov 1. Epub 2018 Nov 1.

Service de stomatologie et chirurgie maxillo-faciale, Cliniques universitaires Saint-Luc, UCL, avenue Hippocrate 10, 1200 Bruxelles, Belgium.

Background: The risk of metastasizing in axillary lymph node is occasional in the head and neck cancers. This pattern of spread is difficult to explain and totally unpredictable even for these lymphophilic cancers.

Observation: A 72-year-old patient benefited, 11 years ago, of surgical oncology care associated with adjuvant radiotherapy for squamous cell carcinoma of the left floor of the mouth (pT4 pN2b M0). Read More

View Article
November 2018
7 Reads

CINSARC SIGNATURE AS A PROGNOSTIC MARKER FOR CLINICAL OUTCOME IN SARCOMAS AND BEYOND.

Genes Chromosomes Cancer 2018 Nov 1. Epub 2018 Nov 1.

INSERM U1037, Cancer Research Center of Toulouse (CRCT), Toulouse.

Prognostication is a key issue for sarcoma patients' care since it triggers the therapeutic approach including chemotherapy, which is still not standard for localized patients. Current prognostic evaluation, internationally based on the FNCLCC grading system, has recently been improved by the CINSARC signature. It outperforms the histology-based grading system by identifying high-risk patients in every grade, even in those considered as having a good clinical outcome. Read More

View Article
November 2018
2 Reads

Identification of highly connected and differentially expressed gene subnetworks in metastasizing endometrial cancer.

PLoS One 2018 1;13(11):e0206665. Epub 2018 Nov 1.

Computational Biology Unit, Department of Informatics, University of Bergen, Bergen, Norway.

We have identified nine highly connected and differentially expressed gene subnetworks between aggressive primary tumors and metastatic lesions in endometrial carcinomas. We implemented a novel pipeline combining gene set and network approaches, which here allows integration of protein-protein interactions and gene expression data. The resulting subnetworks are significantly associated with disease progression across tumor stages from complex atypical hyperplasia, primary tumors to metastatic lesions. Read More

View Article
November 2018
2 Reads

[Evidence of Neoadjuvant Treatment for Pancreatic Cancer].

Gan To Kagaku Ryoho 2018 Oct;45(10):1410-1414

Second Department of Surgery, Wakayama Medical University.

Several multicenter trials are in progressive regarding neoadjuvant treatment for pancreatic cancer to improve survival for pancreatic cancer. However, neoadjuvant treatment for pancreatic cancer is not yet standardized, although neoadjuvant treatment has gained increasing importance in recent years. No clear recommendation for any treatment standard is yet established. Read More

View Article
October 2018
1 Read

Testicular Choriocarcinoma Metastasizing to the Small Bowel Causing Intussusception: Case Report.

J Gastrointest Cancer 2018 Oct 27. Epub 2018 Oct 27.

Pathology Department, Texas Tech Health and Science Center, El Paso, TX, USA.

View Article
October 2018

Report of metastatic ileal neuroendocrine tumor to the submandibular gland.

Int J Surg Case Rep 2018 Oct 19;53:1-4. Epub 2018 Oct 19.

Division of Otolaryngology - Head & Neck Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada.

Background: Neuroendocrine tumors (NETs) of small intestinal origin are generally slow-growing tumors with a relatively high propensity for metastases to surrounding organs and lymphatic tissue. We present the first case of an ileal NET metastasizing to the submandibular gland in a woman with metastatic carcinoid syndrome.

Case Presentation: A 55-year-old female presented with a four-month history of a palpable, left-sided neck mass. Read More

View Article
October 2018
6 Reads

Imaging in secondary tumors of the ovary.

Abdom Radiol (NY) 2018 Oct 25. Epub 2018 Oct 25.

Department of Radiology, Faculty of Medicine, School of Medicine, Hacettepe Universitesi Tıp Fakültesi Hastanesi, 06100, Sıhhiye, Ankara, Turkey.

Metastatic involvement of the ovaries is not rare. The most common tumor types metastasizing to the ovaries, from non-gynecological organs, are breast, colorectal, gastric, and appendix tumors. Lymphogenous, hematogenous, and transcoelomic pathways have all been proposed among potential pathways. Read More

View Article
October 2018
2 Reads

Paget's "Seed and Soil" Theory of Cancer Metastasis: An Idea Whose Time has Come.

Adv Anat Pathol 2019 Jan;26(1):69-74

Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology.

The concept that the pattern of metastatic spread of cancer is not random and that cancer cells exhibit preferences when metastasizing to organs, dates back to 1889 when Steven Paget published his "seed and soil" hypothesis. He proposed that the spread of tumor cells is governed by interaction and cooperation between the cancer cells (seed) and the host organ (soil). Extensive studies during the last several decades have provided a better understanding of the process of metastatic spread of cancer and several stages such as intravasation, extravasation, tumor latency, and development of micrometastasis and macrometastasis have been defined. Read More

View Article
January 2019
19 Reads

Antitumorigenic effect of damnacanthal on melanoma cell viability through p53 and NF-κB/caspase-3 signaling pathways.

Oncol Lett 2018 Nov 3;16(5):6039-6044. Epub 2018 Sep 3.

Department of Dermatology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China.

Melanoma is highly malignant, particularly prone to metastasizing to the skin. The incidence of melanoma varies markedly between countries, and is relatively low in China. The aim of the present study was to investigate the antitumorigenic effect of damnacanthal on melanoma cells, and its molecular mechanism. Read More

View Article
November 2018
2 Reads

CX3CL1 involves in breast cancer metastasizing to the spine via the Src/FAK signaling pathway.

J Cancer 2018 8;9(19):3603-3612. Epub 2018 Sep 8.

Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University.

C-X3-C chemokine ligand 1 (CX3CL1) has been shown to be involved in the development of multiple tumors. Our previous study demonstrated that CX3CL1 may be involved in the process of metastasis of various malignant tumors to the spine, including breast cancer, but the molecular mechanism was still unknown. In the present study, we found that the receptor CX3CR1 was overexpressed in the spinal metastases of breast cancer than in para-tumor tissue. Read More

View Article
September 2018
4 Reads

Diagnostic utility of CD10 immunohistochemical staining on cellblock in differentiating hepatocellular carcinoma from secondary malignancies of liver.

Indian J Pathol Microbiol 2018 Oct-Dec;61(4):510-515

Department of Urology, CNMCH, Kolkata, West Bengal, India.

Background: Differentiation of hepatocellular carcinoma (HCC) from metastatic malignancy in liver may be difficult at times on fine-needle aspiration cytology, especially in case of moderate-to-poorly differentiated tumors. The benefit of cell-block technique is the recognition of histologic pattern of diseases along with application of a wide variety of immunohistochemical (IHC) stains to differentiate hepatic malignancies. In this study, CD10 IHC staining was done on cellblocks prepared from aspirates of clinicoradiologically/cytologically suspected malignant liver neoplasms to differentiate HCC from malignancies metastasizing to liver. Read More

View Article
October 2018
2 Reads

Stridor as the First Presentation of Metastatic Breast Cancer that Was Managed with Chemotherapy: a Case Report.

Indian J Surg Oncol 2018 Sep 25;9(3):336-339. Epub 2018 Jan 25.

3Department of Medical Oncology, Oncology Center- Mansoura University (OCMU), Mansoura, Egypt.

Supraclavicular nodal metastases of breast cancer are rare and occur in about 8% of newly diagnosed cases. It is rarely discussed in the literature that breast cancer was metastasizing to higher levels of the cervical nodes. We report a case of metastatic breast cancer to the deep cervical lymph nodes that caused stridor due to compression of the recurrent laryngeal nerve which was diagnosed by indirect laryngoscopy. Read More

View Article
September 2018
1 Read

Dysregulation of the endothelin pathway in lymphangioleiomyomatosis with no direct effect on cell proliferation and migration.

Sci Rep 2018 Oct 2;8(1):14698. Epub 2018 Oct 2.

Université de Lyon, Université Claude Bernard Lyon 1, INRA, EPHE, IVPC, Viral Infections and Comparative Pathology, UMR754, F69007, Lyon, France.

LAM is a rare low-grade metastasizing lung neoplasm. Inhibitors of mTOR improve clinical outcome of LAM patients by preventing loss of lung function. Nevertheless, other cell targets may be of interest for drug development. Read More

View Article
October 2018
8 Reads
5.080 Impact Factor

A new ligand of CD105 screened out by phage display technology provides a reliable identification of recurrent or metastasizing pleomorphic adenoma from pleomorphic adenoma.

Int Immunopharmacol 2018 Dec 28;65:37-43. Epub 2018 Sep 28.

Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, SunYat-sen University, Guangzhou 510055, China; Guangdong Provincial Key Laboratory of Stomatology, SunYat-sen University, Guangzhou 510055, China. Electronic address:

Objectives: To assess CD105 expression in pleomorphic adenoma (PA), recurrent pleomorphic adenoma (RPA) and metastasizing pleomorphic adenoma (MPA), to identify new epitopes and screen a ligand with high affinity to CD105 by phage display technology, to evaluate the reliability of the new ligand for identifying RPA/MPA from PA.

Methods: Phage display technology was used to screen ligands with high affinity to recombinant human CD105. The ligand with strongest affinity to CD105 was synthesized by FMOC Chemistry according to the sequencing results. Read More

View Article
December 2018
2 Reads
2.472 Impact Factor

Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs.

Dev Cell 2018 10 27;47(2):145-160.e6. Epub 2018 Sep 27.

Division of Molecular Medicine and Genetics, University of Michigan, 5000 LSI, 210 Washtenaw, Ann Arbor, MI 48109-2216, USA; Department of Internal Medicine, University of Michigan, 5000 LSI, 210 Washtenaw, Ann Arbor, MI 48109-2216, USA; Life Sciences Institute, University of Michigan, 5000 LSI, 210 Washtenaw, Ann Arbor, MI 48109-2216, USA; Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Metastasizing breast carcinoma cells have been hypothesized to mobilize tissue-invasive activity by co-opting the proteolytic systems employed by normal mammary epithelial cells undergoing branching morphogenesis. However, the critical effectors underlying morphogenesis remain unidentified, and their relationship to breast cancer invasion programs is yet to be established. Here, we identify the membrane-anchored matrix metalloproteinase, Mmp14/MT1-MMP, but not the closely related proteinase Mmp15/MT2-MMP, as the dominant proteolytic effector of both branching morphogenesis and carcinoma cell invasion in vivo. Read More

View Article
October 2018
1 Read
9.710 Impact Factor

Concurrent pulmonary benign metastasizing leiomyoma and primary lung adenocarcinoma: a case report.

AME Case Rep 2018 4;2:18. Epub 2018 May 4.

Department of Radiology, Shanghai Oriental Hospital, Shanghai 200120, China.

Benign metastasizing leiomyoma (BML) in the lung is a very rare metastatic disease. BML accompanied with primary lung cancer is even more uncommon. In our report, a 38-year-old female who undertook routine computed tomography (CT) scan revealed the pulmonary abnormality. Read More

View Article
May 2018
1 Read

Biomarker-driven targeted therapies for gastric/gastro-esophageal junction malignancies.

Semin Oncol 2018 Jun 20;45(3):133-150. Epub 2018 Mar 20.

Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY. Electronic address:

Gastroesophageal malignancies often contain high amounts of genetic and molecular alterations that result in an aggressive disease capable of rapidly metastasizing to distant organs and early development of drug resistance. Most patients in the Western hemisphere present with locally advanced or metastatic disease that is treated with systemic chemotherapy used either in the neoadjuvant or palliative setting, respectively. This article will review the various recent advances in the development of targeted therapies for the treatment of advanced gastric and gastroesophageal cancer. Read More

View Article
June 2018
8 Reads

Expanding the Spectrum of Genetic Alterations in Pseudomyogenic Hemangioendothelioma With Recurrent Novel ACTB-FOSB Gene Fusions.

Am J Surg Pathol 2018 Dec;42(12):1653-1661

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Pseudomyogenic hemangioendothelioma (PHE) is an uncommon, rarely metastasizing vascular neoplasm with predilection to affect young adults. The tumors often present as multiple nodules involving various tissue planes, including superficial and deep soft tissues as well as bone. Recurrent SERPINE1-FOSB gene fusions have been reported as the hallmark genetic abnormality in PHE, however, in our experience, a number of cases with typical histology lack this genetic abnormality. Read More

View Article
December 2018
5.140 Impact Factor

Malignant melanoma metastasizing to tonsil: A rare presentation.

J Cancer Res Ther 2018 Sep;14(Supplement):S815-S817

Department of Radiation Oncology, Regional Cancer Centre, Trivandrum, Kerala, India.

Malignant melanoma (MM) has a high potential of lymphatic and hematogeneous spread, and metastatic disease is always incurable with a high mortality. We present a rare phenomenon of MM metastasizing to the palatine tonsil. Read More

View Article
September 2018

Case of pulmonary benign metastasizing leiomyoma from synchronous uterine leiomyoma in a postmenopausal woman.

Authors:
H C Jo J C Baek

Gynecol Oncol Rep 2018 Nov 30;26:33-36. Epub 2018 Aug 30.

Department of Obstetrics and Gynecology, College of Medicine, Gyeongsang National University, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea.

Benign metastasizing leiomyoma (BML) is a rare tumor comprising histologically benign smooth muscle cells and exhibits the same histological findings as a uterine myoma although in an extra-uterine location. Most BMLs occur several years after surgery for uterine myoma in women of reproductive age. Here, we report a case of pulmonary BML in a 54-year-old postmenopausal woman with no previous history of myomectomy or hysterectomy. Read More

View Article
November 2018
1 Read

Unusual presentation of a cutaneous metastasis in the face arising from gastric cancer: a case report.

SAGE Open Med Case Rep 2018 10;6:2050313X18795080. Epub 2018 Sep 10.

Department of Dermatology, University Hospital Erlangen, Erlangen, Germany.

A well-known example of gastrointestinal cancers metastasizing to the skin is Sister Mary Joseph's nodule, which usually presents as a cutaneous nodule on the umbilicus. In this case, a 91-year-old man was referred to our dermatology clinic for a rapidly growing 3 cm × 2 cm ulcerative nodule at his chin. Biopsy showed skin metastasis originating from a gastric adenocarcinoma. Read More

View Article
September 2018

CD44/CD44v6 a Reliable Companion in Cancer-Initiating Cell Maintenance and Tumor Progression.

Front Cell Dev Biol 2018 28;6:97. Epub 2018 Aug 28.

Pancreas Section, University Hospital of Surgery, Heidelberg, Germany.

Metastasis is the leading cause of cancer death, tumor progression proceeding through emigration from the primary tumor, gaining access to the circulation, leaving the circulation, settling in distant organs and growing in the foreign environment. The capacity of a tumor to metastasize relies on a small subpopulation of cells in the primary tumor, so called cancer-initiating cells (CIC). CIC are characterized by sets of markers, mostly membrane anchored adhesion molecules, CD44v6 being the most frequently recovered marker. Read More

View Article

Autophagic flux response and glioblastoma sensitivity to radiation.

Cancer Biol Med 2018 Aug;15(3):260-274

Department of Radiotherapy/Oncology.

Objective: Glioblastoma is the most common primary brain tumor in adults and one of the most lethal human tumors. It constitutes a unique non-metastasizing human tumor model with high resistance to radiotherapy and chemotherapy. The current study investigates the association between autophagic flux and glioblastoma cell resistance. Read More

View Article

Nasopharyngeal carcinoma with unusual metastasis to urinary bladder.

J Cancer Res Ther 2018 Jul-Sep;14(5):1160-1161

Department of Histopathology and Cytopathology, Rajiv Gandhi Cancer Institute and Research Centre, Rohini, New Delhi, India.

Nasopharyngeal carcinoma (NPC) metastasizing to urinary bladder is an uncommon site. We report an interesting case of NPC, on follow-up, presenting with unusual urinary symptoms and mimicking a primary bladder cancer. Subsequent bladder cold cup biopsy and immunohistochemistry unfolded a metastasis of NPC, highlighting unexpected and a rare presentation. Read More

View Article
October 2018
1 Read

A rare clinical presentation: a pleomorphic xanthoastrocytoma presenting with intracerebral haemorrhage and metastasizing vigorously-case report and review of the literature.

Childs Nerv Syst 2018 Sep 4. Epub 2018 Sep 4.

Division of Pediatric Neurosurgery, Acıbadem University School of Medicine, Altunizade Mah. Yurtcan Sk. NO:1, 34662, Üsküdar/İstanbul, Turkey.

Metastasis of an intracranial tumour is not a common situation in our daily neurosurgical practice. Pleomorphic xanthoastrocytoma is also a rare glial tumour with relatively a favourable prognosis among other CNS pathologies. Here, we present an anaplastic pleomorphic xanthoastrocytoma case which shows both haematogenous and lymphatic metastasis which is described first time in the up-to-date literature. Read More

View Article
September 2018
7 Reads

Oropharyngeal Squamous Cell Carcinoma Metastasis to Distal Skeletal Muscle on FDG PET/CT.

Clin Nucl Med 2018 Nov;43(11):e402-e403

From the Department of Nuclear Medicine, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia.

We present a case of a tongue squamous cell carcinoma (SCC) metastasizing to distal skeletal muscle detected on FDG PET/CT imaging. A 48-year-old man with locally recurrent tongue SCC underwent a restaging FDG PET/CT to investigate neck and unilateral leg pain. The PET scan showed large, intensely FDG-avid lesions in the right scalene and left hamstring muscles, which were biopsy proven as metastatic SCC. Read More

View Article
November 2018
4 Reads

Cancer of the mandibular gingiva metastasizing to the small intestine.

Auris Nasus Larynx 2018 Aug 28. Epub 2018 Aug 28.

Department of Gastrointestinal Surgery, Saitama Cancer Center, Saitama, Japan.

Head and neck cancer metastasizing to the small intestine is very rare. Here we report a case of cancer of the mandibular gingiva metastasizing to the small intestine. The patient was an 82-year-old man who had squamous cell carcinoma of the mandibular gingiva staged as T2N2bM0. Read More

View Article
August 2018
5 Reads

Cripto-1 Plasmid DNA Vaccination Targets Metastasis and Cancer Stem Cells in Murine Mammary Carcinoma.

Cancer Immunol Res 2018 Nov 24;6(11):1417-1425. Epub 2018 Aug 24.

Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden.

Metastatic breast cancer is a fatal disease that responds poorly to treatment. Cancer vaccines targeting antigens expressed by metastatic breast cancer cells and cancer stem cells could function as anticancer therapies. Cripto-1 is an oncofetal protein overexpressed in invasive breast cancer and cancer-initiating cells. Read More

View Article
November 2018
2 Reads

Prolactin-Secreting Lung Adenocarcinoma Metastatic to the Pituitary Mimicking a Prolactinoma: A Case Report.

Neurosurgery 2018 Aug 20. Epub 2018 Aug 20.

Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background And Importance: Metastasis to the pituitary gland is uncommon in patients with systemic disseminated cancer. Individual articles have reported cases of pituitary metastasis mimicking a prolactinoma, but no case of a prolactin-secreting tumor metastasizing to the pituitary mimicking a prolactinoma has been reported so far.

Clinical Presentation: This article reports a 67-yr-old man with a recent onset of headaches, ophthalmoplegia, hypopituitarism, and hyperprolactinemia who was initially diagnosed with prolactinoma and given bromocriptine in the local hospital. Read More

View Article
August 2018
4 Reads

The Impact of Mesothelin in the Ovarian Cancer Tumor Microenvironment.

Cancers (Basel) 2018 Aug 21;10(9). Epub 2018 Aug 21.

Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46617, USA.

Ovarian cancer is the deadliest gynecological disease among U.S. women. Read More

View Article
August 2018
7 Reads

Malignant Melanoma Metastasizes to Colonic Polyp.

Cureus 2018 Jun 18;10(6):e2822. Epub 2018 Jun 18.

Gastroenterology, Monmouth Medical Center, Long Branch, USA.

Malignant tumors metastasizing to the colon has been observed rarely. Gastrointestinal metastasis can present as benign, unpigmented polyps endoscopically. Most patients do not display any symptoms, and if symptomatic, they usually present with gastrointestinal bleeding. Read More

View Article
June 2018
3 Reads

C-X-C Motif Ligand 1 (CXCL1) from melanoma cells down-regulates the invasion of their metastatic melanoma cells.

Oncotarget 2018 Jul 24;9(57):31090-31097. Epub 2018 Jul 24.

Department of Plastic and Reconstructive Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

The surgical resection of a primary melanoma is sometimes followed by the immediate development of distant metastases, suggesting that the primary melanoma might control the metastatic process. We hypothesized that a paracrine factor(s) from primary melanoma cells might regulate the progression of metastasizing melanoma cells. Here we attempted to identify the factor(s) from primary melanoma cells that regulate the invasion ability of metastatic melanoma cells. Read More

View Article

Functioning of Proteasomes in Lymphogenic Metastasizing of Non-Small-Cell Lung Cancer.

Bull Exp Biol Med 2018 Aug 18;165(4):486-489. Epub 2018 Aug 18.

N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.

Chymotrypsin- and caspase-like activities and expression of the total proteasome pool subunits (α1α2α3α5α6α7) were studied in patients with non-small-cell lung cancer. Proteasome activities were higher in the primary tumors and lymphogenic metastases than in corresponding adjacent lung tissue. The content of α1α2α3α5α6α7 subunits decreased in metastases and remained unchanged in primary tumor tissue. Read More

View Article
August 2018
6 Reads

Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan: from a questionnaire for JCOG 1610 study.

World J Surg Oncol 2018 Aug 8;16(1):160. Epub 2018 Aug 8.

Department of Orthopaedic Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Background: Giant cell tumor of bone (GCTB) is an intermediate tumor known to be locally aggressive, but rarely metastasizing. To plan a prospective study of GCTB, we performed a questionnaire survey for institutions participating in the Bone and Soft Tissue Tumor Study Group (BSTTSG) in the Japan Clinical Oncology Group (JCOG) in 2015.

Methods: We reviewed 158 consecutive patients with primary GCTB treated with curettage without perioperative denosumab from 2008 to 2010 in Japan. Read More

View Article
August 2018
20 Reads

Marked Response of a Hypermutated ACTH-Secreting Pituitary Carcinoma to Ipilimumab and Nivolumab.

J Clin Endocrinol Metab 2018 Oct;103(10):3925-3930

Multidisciplinary Pituitary and Skull Base Tumor Center, Memorial Sloan Kettering Cancer Center, New York, New York.

Context: Pituitary carcinoma is a rare and aggressive malignancy with a poor prognosis and few effective treatment options.

Case: A 35-year-old woman presented with an aggressive ACTH-secreting pituitary adenoma that initially responded to concurrent temozolomide and capecitabine prior to metastasizing to the liver. Following treatment with ipilimumab and nivolumab, the tumor volume of the dominant liver metastasis reduced by 92%, and the recurrent intracranial disease regressed by 59%. Read More

View Article
October 2018
2 Reads

Lobular breast cancer: patterns of intraabdominal metastatic spread on imaging and prognostic significance.

Abdom Radiol (NY) 2018 Aug 3. Epub 2018 Aug 3.

Department of Imaging, Harvard Medical School, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.

Objective: To retrospectively review the frequency, patterns and intra-abdominal sites of metastatic invasive lobular breast cancer, and to correlate the findings with overall survival.

Materials And Methods: From a pathology database search revealing 327 patients with metastatic lobular breast cancer at our institution from January 2004 through August 2014, imaging was available in 116 patients (age range, 31-87 years, mean age, 55). Simple descriptive statistics were performed to record and tabulate the abdominal metastatic spread. Read More

View Article
August 2018
1 Read

Lung metastases from benign uterine leiomyoma: does 18-FDG-PET/CT have a role to play?

Ir J Med Sci 2018 Aug 3. Epub 2018 Aug 3.

Department of Gynaecology Oncology, St. James's Hospital, Dublin8, Ireland.

Uterine leiomyomas are the most common benign gynaecological tumours. However, 0.13 to 6% of them have malignant potential (Robboy et al. Read More

View Article
August 2018
3 Reads

Choroidal metastasis from esophageal squamous cell carcinoma.

Taiwan J Ophthalmol 2018 Apr-Jun;8(2):104-107

Department of Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan.

We presented a rare case of a sole choroidal metastatic tumor from esophageal squamous cell carcinoma (ESCC) without other organ metastasis in Taiwan. A 43-year-old male with ESCC was referred for a 1-month history of decreased vision in his left eye. A 5. Read More

View Article
July 2018
21 Reads

Histopathologic differentiation as a prognostic factor in patients with carcinoma of the hepatopancreatic ampulla of Vater.

J Int Med Res 2018 Nov 20;46(11):4634-4639. Epub 2018 Jul 20.

3 Pathology Department, University of Nis Medical School, Bul.dr Z.Djindjica, Nis, Serbia.

Objective: Periampullary carcinomas are a group of neoplasms with variable histopathology that originate from the anatomical junction of different epithelial types including the bile duct, pancreatic duct, and duodenal mucosa. This study was performed to determine whether the histopathologic type of these tumors should be considered an independent prognostic factor.

Methods: We analyzed the specimen histopathology of 37 patients who underwent radical cephalic pancreatoduodenectomy for carcinoma of the ampulla of Vater during a 5-year period. Read More

View Article
November 2018
4 Reads
1.090 Impact Factor

Aberrant uterine leiomyomas with extrauterine manifestation: intravenous leiomyomatosis and benign metastasizing leiomyomas.

Obstet Gynecol Sci 2018 Jul 18;61(4):509-519. Epub 2018 Jun 18.

Department of Obstetrics and Gynecology, Institute of Women's Medical Life Science, Yonsei University College of Medicine, Seoul, Korea.

Objective: Intravenous leiomyomatosis (IVL) and benign metastasizing leiomyoma (BML) are uncommon variants of benign uterine leiomyomas with extrauterine manifestations. Categorizing the extent of disease allows clinicians to delineate the clinical spectrum and the level of sophistication for complete surgical resection.

Methods: Twelve patients with IVL and BML were reviewed. Read More

View Article
July 2018
6 Reads