66 results match your criteria Metastasizing Benign Mixed Tumor


Maxillofacial diagnostic features of the enigmatic metastasizing pleomorphic adenoma.

Int J Oral Maxillofac Surg 2020 Jul 28;49(7):841-847. Epub 2020 Jan 28.

Department of Oral and Maxillofacial Surgery, Hebrew University-Hadassah, Jerusalem, Israel; Arab American University-AAUP, Palestinian Authority.

Considering the confusion in the literature regarding local recurrence, spread, or metastases of pleomorphic adenoma (PA) in the head and neck region, the aim of this study was to enhance understanding of the characteristics of metastasizing pleomorphic adenoma (MPA) by reviewing the literature and presenting a case. English language articles with proof of metastases were included in the literature review. Of the 80 cases in the literature with MPA, 46 were female and 33 were male (sex missing for one case). Read More

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Metastasizing Pleomorphic Adenoma: Recurrent PLAG1/HMGA2 Rearrangements and Identification of a Novel HMGA2-TMTC2 Fusion.

Am J Surg Pathol 2019 08;43(8):1145-1151

Department of Laboratory Medicine and Pathobiology, University of Toronto.

Pleomorphic adenoma (PA) is the most common salivary gland neoplasm. On a molecular level PA is characterized by a translocation involving PLAG1 or HMGA2. PA is considered to be a benign tumor although it can undergo malignant transformation. Read More

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CD73 a novel marker for the diagnosis of benign and malignant salivary gland tumors.

J Clin Exp Dent 2019 Mar 1;11(3):e213-e218. Epub 2019 Mar 1.

Undergraduate Student, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Ecto-5'-nucleotidase (CD73) plays an important role in the development of several types of cancer; however, its prognostic significance in salivary gland tumors remains unknown. The current study was conducted to investigate the expression of CD73 in such tumors.

Material And Methods: In this retrospective study, immunohistochemical expression of CD73 was evaluated in 25 pleomorphic adenomas, 20 mucoepidermoid carcinomas and 20 adenoid cystic carcinomas using the Envision technique. Read More

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[Hepatic metastasis of a pleomorphic adenoma].

Medicina (B Aires) 2019 ;79(1):64-66

Servicio de Cirugía General, Hospital Alemán, Buenos Aires, Argentina.

Pleomorphic adenoma is the most benign tumor of the salivary glands. It can undergo a malignant transformation to carcinoma and metastasize to distant organs, sometimes it can metastasize as a benign tumor. We present the case of an 82 years old male with hepatic lesion detected by ultrasound in routine urologic follow-up. Read More

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Metastasizing uterine mullerian adenosarcoma in a young female: Diagnostic enigma.

Indian J Pathol Microbiol 2018 Jul-Sep;61(3):440-442

Department of Surgical Oncology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.

Uterine adenosarcomas are uncommon tumors. It is a biphasic tumor with both epithelial and mesenchymal component. The epithelial component is benign in nature, and the mesenchymal component is malignant. Read More

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November 2018

Metastasizing pleomorphic adenoma in the multiple organs: A case report on FDG-PET/CT imaging.

Medicine (Baltimore) 2018 Jun;97(23):e11077

Department of Nuclear Medicine Department of Diagnostic Imaging Department of Pathology, The Cancer Institute Hospital of JFCR, Tokyo, Japan.

Rationale: Pleomorphic adenoma, the most common tumor of the salivary glands, is usually benign. It is well known, however, that pleomorphic adenomas occasionally undergo malignant transformation to carcinoma ex pleomorphic adenoma and can metastasize. More rarely pleomorphic adenomas can metastasize without histological malignant transformation. Read More

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Metastasising Pleomorphic Salivary Adenoma: A Rare Case Report of a Massive Untreated Minor Salivary Gland Pleomorphic Adenoma with Concurrent Ipsilateral Cervical Node Metastases.

Head Neck Pathol 2019 Sep 3;13(3):500-506. Epub 2018 May 3.

OMFS Consultant, St John's Hospital, Livingston, Scotland, UK.

Salivary gland tumours constitute approximately 1-5% of all human neoplasms. Pleomorphic adenoma (PA) is the commonest benign neoplasm affecting the parotid gland most often (> 75%), followed by the submandibular gland (13%), then the palate (9%). Metastasising pleomorphic adenoma (MPA) is extremely rare. Read More

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September 2019

Metastasizing pleomorphic adenoma of the parotid gland.

Ecancermedicalscience 2017 15;11:758. Epub 2017 Aug 15.

Hospital de Clinicas, Piso 2, Consultorio 228, San Bernardino, Caracas, 1010 584248518639/2125086228, Venezuela.

Salivary gland tumours are estimated to represent approximately 3% of all head and neck tumours. About 70-80% of these neoplasms occur in the major salivary glands, with the parotid gland being the most commonly affected site. The metastasizing pleomorphic adenoma (MPA) has histological characteristics of pleomorphic adenoma, but it has the capacity to generate local recurrences and distant metastases (mainly bones, lungs, and lymph nodes). Read More

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Metastasizing Pleomorphic Adenoma Case Report and Review of the Literature.

Head Neck Pathol 2017 Dec 25;11(4):487-493. Epub 2017 May 25.

Department of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, 355 Squire Hall, Buffalo, NY, 14214, USA.

Pleomorphic adenoma (PA) is by far the most common salivary gland tumor. It is well known that PA can undergo malignant transformation. However, in rare occasions it can metastasize preserving its benign phenotype. Read More

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December 2017

Benign metastasizing pleomorphic adenoma in liver mimicking synchronic metastatic disease from colorectal cancer: a case report with emphasis on imaging findings.

Acta Radiol Open 2015 Aug 7;4(8):2058460115594199. Epub 2015 Aug 7.

Department of Radiology, Oslo University Hospital, Oslo, Norway.

Pleomorphic adenoma of the parotid gland with metastases to the liver is a rare etiology of focal liver lesions, and there are no described pathognomonic imaging features. We report a patient who presented with a newly diagnosed rectal cancer and multiple cystic liver lesions suspicious of mucinous synchronous liver metastases. Following chemotherapy no reduction in the number or size of the liver lesions was observed. Read More

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Metastasising pleomorphic adenoma: Systematic review.

Int J Surg 2015 Jul 6;19:137-45. Epub 2015 May 6.

Department of General Surgery, Royal Surrey County Hospital, UK.

Background: Pleomorphic adenoma (PA) is the commonest benign neoplasm of salivary glands.(1) PA can undergo malignant transformation to ex-pleomorphic adenoma (2,3) but rarely, can metastasise without malignant transformation.(4,5) Metastasising pleomorphic adenoma (MPA) is a rare malignant tumour which, histologically, is indistinguishable from PA yet produces secondary tumours in distant sites. Read More

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Carcinoma ex pleomorphic adenoma: Diagnostic dilemma and treatment protocol.

Indian J Dent 2014 Jul;5(3):157-60

Department of Oral and Maxillofacial Surgery, Vokkaligara Sangha Dental College and Hospital and Research Centre, KR Road, VV Puram, Bangalore, Karnataka, India.

Carcinoma ex pleomorphic adenoma (CXPA) is a carcinoma arising from a primary or recurrent benign pleomorphic adenoma. It often poses a diagnostic challenge to clinicians and pathologists. The entity is difficult to diagnose preoperatively. Read More

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Metastasizing pleomorphic adenoma of the submandibular gland: a case report.

Pathologica 2014 Mar;106(1):29-31

Pleomorphic adenoma (PA), originally called mixed tumour, is the most common neoplasm of the salivary glands. It is usually a benign, slow-growing and well-circumscribed tumour. However, PA may occasionally give rise to metastases that usually occur after a previous recurrence. Read More

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Metastasizing "benign" pleomorphic salivary adenoma: a dramatic case-report and literature review.

J Craniomaxillofac Surg 2014 Dec 14;42(8):1562-5. Epub 2014 Jan 14.

Maxillofacial Surgery Unit, Alma Mater Studiorum University of Bologna, Bologna, Italy.

Pleomorphic salivary adenomas are the most common benign neoplasms affecting the salivary glands. Very occasionally however, metastatic lesions are identified in patients with a history of PSA, which, on detailed pathological evaluation, are found to exhibit all the histological hallmarks of the preceding benign lesions. Diagnosis of benign metastasizing pleomorphic adenoma of the salivary gland is extremely rare and still under debate. Read More

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December 2014

A case of metastasizing pleomorphic adenoma in the maxillary bone appearing twenty years after initial resection of pleomorphic adenoma of the hard palate.

Pathol Int 2013 Sep 28;63(9):463-8. Epub 2013 Aug 28.

Department of Pathology, Kurume University School of Medicine, Kurume, Japan.

Metastasizing pleomorphic adenoma (MPA) is the inexplicable metastasis of a histologically benign pleomorphic adenoma (PA). Approximately 50 cases have been reported. A 62-year-old woman noticed pain in the upper molar area. Read More

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September 2013

Metastasizing "benign" cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases.

Am J Surg Pathol 2013 Apr;37(4):484-95

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Cutaneous fibrous histiocytoma (FH) is considered a benign tumor; however, certain types of FH have been shown to have a tendency for local recurrence, and there are rare reported cases of metastasis. In this study, 16 cases of morphologically benign FH with locoregional or distant metastasis were identified in consult files. Pathologic features of primary, recurrent, and metastatic tumors, as well as clinical outcome, were evaluated. Read More

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Benign metastasizing pleomorphic adenoma presenting as a solitary kidney mass: imaging features.

Urology 2012 Aug 27;80(2):e17-8. Epub 2012 Jun 27.

Division of Abdominal Imaging and Intervention, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Benign metastasizing pleomorphic adenoma is a rare condition that occurs in patients with a prior history of pleomorphic adenoma of the salivary glands. Metastases to the kidney are extremely rare, and, to the best of our knowledge, their imaging appearance on multiple cross-sectional imaging modalities has not been described. We present a solitary metastasis to the kidney in a 40-year-old woman. Read More

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Benign pleomorphic adenoma of the soft palate metastasizing to the sphenoid sinus.

Clin Exp Otorhinolaryngol 2010 Sep 17;3(3):172-5. Epub 2010 Sep 17.

Department of Otorhinolaryngology-Head and Neck Surgery, Yeungnam University College of Medicine, Daegu, Korea.

A benign pleomorphic adenoma is the most common tumor of the salivary glands. This tumor has the potential to metastasize to bone, the head and neck region, visceral organs and skin. Although there a few reports about a benign pleomorphic adenoma metastasizing to the maxillary sinus in the paranasal sinuses, there are no reports about a metastatic benign pleomorphic adenoma in the sphenoid sinus. Read More

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September 2010

A hepatic metastasis from pleomorphic adenoma of salivary gland: an unusual presentation.

Hepatogastroenterology 2010 Mar-Apr;57(98):330-3

Nazih Zuhdi Transplant Institute, Integris Baptist Medical Center, 3300 NW Expressway, Oklahoma City, Oklahoma 73112, USA.

Metastasizing pleomorphic adenoma (PA) is a rare condition displaying benign histological features as of PA in the metastatic lesion. The present study report a case of 46 years old male presented with space occupying lesion in the right lobe of liver. Patient underwent extended right hepatectomy for space occupying lesion in liver and the histological features were suggestive of metastatic benign pleomorphic adenoma. Read More

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Expression of hormonal receptor in patients with metastasizing pleomorphic adenoma of the major salivary gland; a clinicopathological report of three cases.

J Med Assoc Thai 2009 Sep;92(9):1250-5

Department of Pathology, Faculty ofMedicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Metastasizing pleomorphic adenoma is an uncommon malignant tumor of the salivary gland demonstrating benign epithelial and modified myoepithelial elements intermingling with tissue of mucoid, myxoid, or chondroid appearance that inexplicably manifests local or distant metastasis.

Objective: To determine the expression of hormonal receptor in the patients with metastasizing pleomorphic adenoma of the major salivary gland.

Material And Method: Medical records, clinical and pathologic findings of three patients who were diagnosed as metastasizing pleomorphic adenoma were reviewed. Read More

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September 2009

An intracapsular carcinoma ex pleomorphic adenoma with lung metastases composed exclusively of benign elements: histological evidence of a continuum between metastasizing pleomorphic adenoma and carcinoma ex pleomorphic adenoma.

Pathol Res Pract 2010 Jul 7;206(7):480-3. Epub 2009 Aug 7.

Department of Cellular Pathology, Birmingham Heartlands Hospital, Bordesley Green, B9 5SS, UK.

Malignant mixed tumors of the salivary glands, encompassing carcinoma ex pleomorphic adenoma (ca ex PA), carcinosarcoma and metastasizing pleomorphic adenoma (mPA), are rare neoplasms. Ca ex PA arises in a pre-existing pleomorphic adenoma (PA). When the malignant component does not breach the capsule of the parent PA, the lesion is termed intracapsular ca ex PA, a neoplasm which is thought to have no metastatic potential. Read More

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Fine-needle aspiration (FNA) and pleural fluid cytology diagnosis of benign metastasizing pleomorphic adenoma of the parotid gland in the lung: a case report and review of literature.

Diagn Cytopathol 2009 Nov;37(11):828-31

Department of Pathology, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, Florida 33136, USA.

Lesions that contain abundant benign myoepithelial cells, including pleomorphic adenomas of salivary gland origin, may present a diagnostic challenge in fine-needle aspiration (FNA) specimens. Benign metastasizing pleomorphic adenoma is a rare neoplasm, in which the benign appearing pleomorphic adenoma, without any histological evidence of malignancy, metastasizes to distant sites including lung. In the absence of clinical history of a pre-existing myoepithelial neoplasm, the presence of myoepithelial cells in the lung or any other organs besides salivary glands may create diagnostic difficulty. Read More

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November 2009

Spectrum of malignancy in mixed tumors of salivary gland: a morphological and immunohistochemical review of 23 cases.

Indian J Pathol Microbiol 2009 Apr-Jun;52(2):150-4

Section of Histopathology, Aga Khan University, Karachi, Pakistan.

Malignancy arising in mixed tumors of the salivary gland is a distinct entity that can occur sporadically or in association with a background of pleomorphic adenoma. Carcinoma arising with a background of pleomorphic adenoma is well documented. However, there are rare occurrences of aggressive de novo carcinosarcomas of the parotid that have been reported. Read More

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Metastasizing pleomorphic adenoma presenting as an asymptomatic kidney tumor twenty-nine years after parotidectomy - urological viewpoint and overview of the literature to date.

Rare Tumors 2009 Dec 28;1(2):e54. Epub 2009 Dec 28.

Department of Urology, and.

Pleomorphic adenomas (benign mixed tumors) are the most common tumors of glandular origin in the head and neck and are one of the few benign neoplasms that can undergo malignant transformation.(1) Mixed tumors that are seemingly benign at the microscopic level but metastasize have been termed metastasizing mixed tumors (MZMTs). The entity of metastasizing benign mixed tumors has been reported since the early 1940s, with up to approximately 50 cases described in the literature to date. Read More

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December 2009

Pleomorphic adenoma of the parotid gland metastasizing to the scapular region: a case report.

Acta Cytol 2008 Nov-Dec;52(6):733-5

Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Background: Metastasizing pleomorphic adenoma (MPA) is a rare, incompletely understood enigmatic entity having the histologic appearance of benign pleomorphic adenoma and clinically malignant behavior. We report a case of MPA of the parotid gland that metastasized to the scapular region 6 years after the appearance of the primary lesion in the left parotid gland.

Case: A 35-year-old woman presented with a palpable soft to firm mass of 3-cm diameter in the left scapular region that was slightly mobile over the underlying structures and a small swelling at the operated site of the parotid region. Read More

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January 2009

Metastasizing pleomorphic adenoma of the salivary gland.

Arch Pathol Lab Med 2008 Sep;132(9):1445-7

Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.

Metastasizing pleomorphic adenoma of salivary glands is a group of rare tumors that are histologically identical to benign mixed tumors and that inexplicably metastasize. A review of the literature revealed that it usually occurs after multiple local recurrences, and the interval between diagnosis of primary pleomorphic adenoma and metastases ranges between 3 and 52 years. The most common site for metastasis is bone, followed by the head and neck and lung. Read More

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September 2008

[Carcinoma ex pleomorphic adenoma of major salivary glands--a clinicopathologic review].

Otolaryngol Pol 2007 ;61(5):687-93

Katedra i Klinika Chorób Uszu, Nosa, Gardła i Krtani AM w Gdańsku.

Background: Pleomorphic adenoma (PA) is the most common neoplasm of the major salivary glands. There are three subtypes of malignant PA: carcinoma ex pleomorphic adenoma (CXPA); carcinosarcoma (true malignant mixed tumor) and metastasizing pleomorphic adenoma. The most common subtype of malignant PA is CXPA which develops in primary or recurrent PA. Read More

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Multiple pulmonary metastases from benign pleomorphic adenoma.

Asian Cardiovasc Thorac Ann 2008 Jan;16(1):62-4

Division of Cardiothoracic Surgery, Department of Surgery, University of Hong Kong Medical Center, Grantham Hospital, Hong Kong, China.

Metastasizing pleomorphic adenoma is a rare condition of metastasis from a histologically benign salivary gland tumor. We report a case of metastasizing pleomorphic adenoma presenting with multiple bilateral lung metastases, and discuss the clinical aspects of this disease. Read More

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January 2008

[Metastasizing pleomorphic adenoma of the submandibular gland: a case report].

Hua Xi Kou Qiang Yi Xue Za Zhi 2007 Jun;25(3):307-9

Dept. of Pathology, West China College of Stomatology, Sichuan University, Chengdu 610041, China.)

Metastasizing pleomorphic adenomas without histological evidence of malignancy have rarely been reported. A case of 30-year-old woman with a mass which showed a benign pleomorphic adenoma appearanced histologically in the left submandibular gland and right supercollarbone respectively was described. Eight years ago, the patient suffered from pleomorphic adenoma of the left submandibular gland. Read More

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A case of pleomorphic adenoma of the parotid gland metastasizing to a mediastinal lymph node.

Am J Otolaryngol 2007 Mar-Apr;28(2):130-3

Department of Otolaryngology-Head and Neck Surgery, Beth Israel Medical Center, New York, NY 10467, USA.

Objective: Pleomorphic adenomas are the most common salivary gland tumors and are typically cured with complete surgical excision. There are rare reports, however, in which these histologically benign tumors have inexplicably metastasized to distant sites. We present a case of a patient who presented, 27 years after excision of a parotid pleomorphic adenoma, with a recurrence in the parotid bed and a mediastinal metastasis. Read More

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