12,656 results match your criteria Metabolism[Journal]


Research developments in metabolism 2018.

Metabolism 2018 Nov 29. Epub 2018 Nov 29.

Section of Endocrinology, Beth-Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States of America.

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November 2018

Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics.

Metabolism 2018 Nov 28. Epub 2018 Nov 28.

Section of Endocrinology, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA.

The obesity epidemic is closely associated with the rising prevalence and severity of nonalcoholic fatty liver disease (NAFLD): obesity has been linked not only with simple steatosis (SS), but also with advanced disease, i.e., nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis and hepatocellular carcinoma (HCC). Read More

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November 2018
1 Read

Central obesity transition increased urinary levels of 8-hydroxydeoxyguanosine in male adults: A 3-year follow up study.

Metabolism 2018 Dec 1. Epub 2018 Dec 1.

Department of Occupational and Environmental Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR. China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR. China. Electronic address:

Objective: Association of oxidative DNA damage with gain in anthropometric indices has not been fully elucidated.

Methods: In this study, participants (n = 1151) were derived from the baseline visit of Wuhan residents in the Wuhan-Zhuhai Cohort Study. The participants finished the physical examinations at both baseline and 3-year follow up. Read More

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December 2018
1 Read

FoxO1 regulates leptin-induced mood behavior by targeting tyrosine hydroxylase.

Metabolism 2018 Nov 27. Epub 2018 Nov 27.

Department of Oral Biology, BK21 PLUS, Yonsei University College of Dentistry, Seoul, 03722, Korea; Departments of Global Medical Science and Wellness & Healthy Aging, Wonju College of Medicine, Yonsei University, Wonju, 26426, Korea. Electronic address:

Purpose: While leptin has been associated with various psycho-physiological functions, the molecular network in leptin-mediated mood regulation remains elusive.

Methods: Anxiolytic behaviors and tyrosine hydroxylase (TH) levels were examined after leptin administration. Functional roles of STAT3 and FoxO1 in regulation of TH expression were investigated using in vivo and in vitro systems. Read More

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November 2018

Physiology of energy homeostasis: models, actors, challenges and the glucoadipostatic loop.

Metabolism 2018 Nov 27. Epub 2018 Nov 27.

Institut de Recherche Biomédicale des Armées, Unité de Physiologie des Exercices et Activités en Conditions Extrêmes, Département Environnements Opérationnels, Brétigny-sur-Orge, France.

The aim of this review is to discuss the physiology of energy homeostasis (EH), which is a debated concept. Thus, we will see that the set-point theory is highly challenged and that other models integrating an anticipative component, such as energy allostasis, seem more relevant to experimental reports and life preservation. Moreover, the current obesity epidemic suggests that EH is poorly efficient in the modern human dietary environment. Read More

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November 2018
2 Reads

Adiponectin homolog novel osmotin protects obesity/diabetes-induced NAFLD by upregulating AdipoRs/PPARα signaling in ob/ob and db/db transgenic mouse models.

Metabolism 2019 Jan 25;90:31-43. Epub 2018 Oct 25.

Division of Applied Life Science (BK 21), College of Natural Sciences, Gyeongsang National University, Jinju 660-701, Republic of Korea. Electronic address:

Background: In metabolic disorders, adiponectin and adiponectin receptors (AdipoR1/R2) signaling has a key role in improving nonalcoholic fatty liver disease (NAFLD) in obesity-associated diabetes.

Objective: To the best of our knowledge, here, we reported for the first time the underlying mechanistic therapeutic efficacy of the novel osmotin, a homolog of mammalian adiponectin, against NAFLD in leptin-deficient ob/ob and db/db mice.

Methods: The ob/ob and db/db mice were treated with osmotin at a dose of 5 μg/g three times a week for two weeks. Read More

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January 2019
3 Reads

Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα.

Metabolism 2018 Nov 20. Epub 2018 Nov 20.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Scientific Research Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Background: Metformin is a first-line drug for treating type 2 diabetes and has gained considerable interest as a potential anticancer agent. Increasing evidence suggests that metformin antagonizes diabetes and tumors through disrupting metabolic homeostasis and altering energy state. However, whether AMP activated protein kinase (AMPK) contributes to such effects of metformin remains controversial. Read More

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November 2018
2 Reads

Maternal lipid profile differs by gestational diabetes physiologic subtype.

Metabolism 2018 Nov 20. Epub 2018 Nov 20.

Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, United States of America; Centre de Recherche du Centre hospitalier universitaire de Sherbrooke (CHUS), Québec, Canada; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America. Electronic address:

Aim To characterize lipid profiles in women with different gestational diabetes mellitus (GDM) physiologic subtypes.

Methods: We measured seven lipid markers (total cholesterol, LDL, HDL, triglycerides, non-esterified fatty acids (NEFA), ApoA, ApoB) in fasting plasma collected in a prospective cohort of 805 pregnant women during second trimester. We estimated insulin sensitivity and secretion using oral glucose tolerance test-based validated indices. Read More

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November 2018
2 Reads

Metabolically healthy versus metabolically unhealthy obesity.

Metabolism 2018 Nov 17. Epub 2018 Nov 17.

Department of Clinical and Molecular Medicine, "La Sapienza" University, Rome, Italy. Electronic address:

Obesity-related disease complications reduce life quality and expectancy and increase health-care costs. Some studies have suggested that obesity not always entails metabolic abnormalities and increased risk of cardiometabolic complications. Because of the lack of universally accepted criteria to identify metabolically healthy obesity (MHO), its prevalence varies widely among studies. Read More

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November 2018

Could the endocrine disruptor bisphenol-a be implicated in the pathogenesis of oral and oropharyngeal cancer? Metabolic considerations and future directions.

Metabolism 2018 Nov 17. Epub 2018 Nov 17.

Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias street, 11527 Athens, Greece. Electronic address:

Bisphenol-A (BPA), a prototype endocrine disrupting molecule, has been associated with many disease entities such as diabetes mellitus, obesity, polycystic ovarian disease, cardiovascular disease, reproductive and neurodevelopmental disorders. BPA has also been associated mainly with hormone sensitive cancers such as breast, prostate, endometrial, ovarian, testicular and thyroid cancers but also non-hormonal sensitive cancers such as cervical and lung cancers, osteosarcoma and meningioma. Recent research has investigated the sources of contamination which are responsible for higher BPA concentrations in the oral cavity and oropharyngeal space, representing the first site of BPA exposure after ingestion. Read More

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November 2018
2 Reads

High plasma FGF21 levels predicts major cardiovascular events in patients treated with atorvastatin (from the Treating to New Targets [TNT] Study).

Metabolism 2018 Nov 16. Epub 2018 Nov 16.

Lipid Research Group, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.

Background: Higher plasma fibroblast growth factor 21 (FGF21) levels predict incident cardiovascular events in type 2 diabetes patients. However, whether FGF21 levels predict cardiovascular events in statin-treated patients in the general population is unknown. We investigated whether FGF21 levels predict major cardiovascular event (MCVE) in the Treating to New Targets (TNT) trial participants. Read More

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November 2018
2 Reads

Glucagon-like peptide 1 (GLP-1) drives postprandial hyperinsulinemic hypoglycemia in pregnant women with a history of roux-en-Y gastric bypass operation.

Metabolism 2018 Nov 15. Epub 2018 Nov 15.

Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Unit of Gender Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. Electronic address:

Background: The influential role of incretin hormones on glucose metabolism in patients with a history of Roux-en-Y gastric bypass (RYGB) has been investigated thoroughly, but there has been little examination of the effect of incretins and ectopic lipids on altered glucose profiles, especially severe hypoglycemia in pregnant women with RYGB.

Methods: In this prospective clinical study, an oral glucose tolerance test (OGTT), an intravenous glucose tolerance test (IVGTT), and continuous glucose monitoring (CGM) were conducted in 25 women with RYGB during pregnancy, 19 of normal weight (NW) and 19 with obesity (OB) between the 24th and the 28th weeks of pregnancy, and 3 to 6 months post-partum. Post-partum, the ectopic lipid content in the liver, heart, and skeletal muscle was analyzed using H-magnetic resonance spectroscopy (H-MRS). Read More

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November 2018
6 Reads

Obesity and dyslipidemia.

Metabolism 2018 Nov 14. Epub 2018 Nov 14.

Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.

Obesity, a pandemic of the modern world, is intimately associated with dyslipidemia, which is mainly driven by the effects of insulin resistance and pro-inflammatory adipokines. However, recent evidence suggests that obesity-induced dyslipidemia is not a unique pathophysiological entity, but rather has distinct characteristics depending on many individual factors. In line with that, in a subgroup of metabolically healthy obese (MHO) individuals, dyslipidemia is less prominent or even absent. Read More

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November 2018
3 Reads

Obesity and Cancer Risk: Emerging biological mechanisms and perspectives.

Metabolism 2018 Nov 13. Epub 2018 Nov 13.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece. Electronic address:

Continuously rising trends in obesity-related malignancies render this disease spectrum a public health priority. Worldwide, the burden of cancer attributable to obesity, expressed as population attributable fraction, is 11.9% in men and 13. Read More

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November 2018
12 Reads

CHARACTERISTICS OF OBESITY IN POLYCYSTIC OVARY SYNDROME: ETIOLOGY, TREATMENT, AND GENETICS.

Metabolism 2018 Nov 13. Epub 2018 Nov 13.

The Cholesterol, Metabolism, and Thrombosis Research Center, 3906 Middleton Avenue, Cincinnati, OH, 45220.

Polycystic ovary syndrome (PCOS) has multiple etiologies including ovarian and adrenal hyperandrogenism, neuro-endocrine and hypothalamic-pituitary dysfunction, and disorders of peripheral insulin resistance. Obesity is neither necessary nor sufficient for the PCOS phenotype, and the association of PCOS with obesity is not universal, with national, cultural, and ethnic differences. Obesity, particularly visceral adiposity which is common in obese and non-obese women with PCOS, amplifies and worsens all metabolic and reproductive outcomes in PCOS. Read More

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November 2018
4 Reads

Conditioned media from contracting skeletal muscle potentiates insulin secretion and enhances mitochondrial energy metabolism of pancreatic beta-cells.

Metabolism 2018 Nov 13. Epub 2018 Nov 13.

School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, UK; Institute for Metabolism and Systems Research (IMSR), University of Birmingham, UK.

Aims/hypothesis: In this study, we aimed to examine real-time effects of molecules released by contracting skeletal muscle on the insulin secretory function of β-cells using a novel perifusion platform. We hypothesised that media conditioned by contracting skeletal muscle will influence insulin secretion and mitochondrial energy metabolism in β-cells under normal and type-2 diabetic conditions.

Methods: INS-1832/3 pseudoislets were perifused with media from C2C12 myotubes treated with or without electrical pulse stimulation (EPS; 40 V, 1. Read More

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November 2018
1 Read

Leptin trajectories from birth to mid-childhood and cardio-metabolic health in early adolescence.

Metabolism 2018 Nov 6. Epub 2018 Nov 6.

Division of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address:

Objectives: Leptin is a hormone produced by adipose tissue that promotes satiety, and some evidence suggests that greater early life leptin exposure prevents excessive adiposity gain in later life. However, few studies have analyzed dynamic changes in leptin throughout childhood in relation to later cardio-metabolic health. Our study aims to identify distinct leptin trajectories in childhood, and to examine their associations with cardio-metabolic outcomes in adolescence. Read More

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November 2018
4 Reads

Burden of cancer attributable to obesity, type 2 diabetes and associated risk factors.

Metabolism 2018 Nov 6. Epub 2018 Nov 6.

Hospital Virgen del Camino, carretera de Chipiona km 0.64, 11540 Sanlúcar de Barrameda, Cádiz, Spain. Electronic address:

Overweight and obesity constitute a global pandemic with devastating consequences that affect >2 billion people. Obesity plays a central role in morbidity and mortality of diseases of multiple organs and systems, and it is a major contributor to the growing incidence of cancer. There is now sufficient level of evidence for the association between overweight and 11 types of cancer, among which are two of the most common cancers worldwide, those of the colorectum and postmenopausal breast. Read More

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November 2018
12 Reads

Obesity and cardiovascular disease: revisiting an old relationship.

Metabolism 2018 Nov 3. Epub 2018 Nov 3.

First Department of Propaedeutic Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece. Electronic address:

A wealth of clinical and epidemiological evidence has linked obesity to a broad spectrum of cardiovascular diseases (CVD) including coronary heart disease, heart failure, hypertension, stroke, atrial fibrillation and sudden cardiac death. Obesity can increase CVD morbidity and mortality directly and indirectly. Direct effects are mediated by obesity-induced structural and functional adaptations of the cardiovascular system to accommodate excess body weight, as well as by adipokine effects on inflammation and vascular homeostasis. Read More

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November 2018
3 Reads

Genetics and epigenetics in obesity.

Metabolism 2018 Nov 3. Epub 2018 Nov 3.

Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig 04103, Germany; University of Oslo, Institute of Clinical Medicine, Oslo 0316, Norway; Akershus University Hospital, Department of Clinical Molecular Biology, Medical Division, Lørenskog 1478, Norway. Electronic address:

Obesity is among the most threatening health burdens worldwide and its prevalence has markedly increased over the last decades. Obesity maybe considered a heritable trait. Identifications of rare cases of monogenic obesity unveiled that hypothalamic circuits and the brain-adipose axis play an important role in the regulation of energy homeostasis, appetite, hunger and satiety. Read More

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November 2018
4 Reads

Pharmacotherapy of obesity: Available medications and drugs under investigation.

Metabolism 2018 Nov 1. Epub 2018 Nov 1.

Division of Endocrinology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA 02215.

Obesity is a chronic disease with a continuously rising prevalence that currently affects more than half a billion people worldwide. Energy balance and appetite are highly regulated via central and peripheral mechanisms, and weight loss triggers a homeostatic response leading to weight regain. Lifestyle and behavioral modifications are the cornerstones of obesity management; however, they often fail to achieve or sustain long-term weight loss. Read More

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November 2018
7 Reads

VOmax is associated with measures of energy expenditure in sedentary condition but does not predict weight change.

Metabolism 2019 Jan 29;90:44-51. Epub 2018 Oct 29.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.

Background/objectives: Energy expenditure measured under sedentary conditions predicts weight change but evidence that directly measured VOmax is associated with weight change is lacking. The aim of this study was to determine the associations of VOmax with measures of predominantly sedentary 24-h thermogenesis, and subsequent weight change.

Subjects/methods: Three hundred fifty-seven individuals (162 females; 27 Blacks, 72 Caucasians, and 258 American Indians) had measures of body composition, resting metabolic rate (RMR), and intermittent treadmill run test for assessment of VOmax. Read More

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January 2019
2 Reads

Exercise in the management of obesity.

Metabolism 2018 Oct 29. Epub 2018 Oct 29.

Laboratory of Evaluation of Human Biological Performance, School of Physical Education and Sport Science at Thessaloniki, Aristotle University of Thessaloniki, Greece. Electronic address:

Obesity is a multifactorial disease with increasing incidence and burden on societies worldwide. Obesity can be managed through everyday behavioral changes involving energy intake and energy expenditure. Concerning the latter, there is strong evidence that regular exercise contributes to body weight and fat loss, maintenance of body weight and fat reduction, and metabolic fitness in obesity. Read More

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October 2018
2 Reads

Association between arginase-containing platelet-derived microparticles and altered plasma arginine metabolism in polycystic ovary syndrome.

Metabolism 2019 Jan 24;90:16-19. Epub 2018 Oct 24.

Institute for Vascular Signalling, Centre of Molecular Medicine, Goethe University, Frankfurt am Main D-60596, Germany; German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt am Main, Germany. Electronic address:

Background: Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disease associated with insulin resistance and increased risk of cardiovascular diseases. However, a biomarker for potential cardiovascular disease in PCOS patients is not available.

Materials And Methods: Twenty-two patients with PCOS and 22 healthy controls were included in the present study and amino acid profiling was performed on fasting plasma samples. Read More

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January 2019
1 Read

Role of the α2 subunit of AMP-activated protein kinase and its nuclear localization in mitochondria and energy metabolism-related gene expressions in C2C12 cells.

Metabolism 2019 Jan 23;90:52-68. Epub 2018 Oct 23.

Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan. Electronic address:

Background: AMP-activated protein kinase (AMPK), a heterotrimer with α1 or α2 catalytic subunits, acts as an energy sensor and regulates cellular homeostasis. Whereas AMPKα1 is necessary for myogenesis in skeletal muscle, the role of AMPKα2 in myogenic differentiation and energy metabolism-related gene expressions has remained unclear. We here examined the specific roles of AMPKα1 and AMPKα2 in the myogenic differentiation and mitochondria and energy metabolism-related gene expressions in C2C12 cells. Read More

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January 2019
3 Reads

Stem cells in the treatment of diabetes mellitus - Focus on mesenchymal stem cells.

Metabolism 2019 Jan 18;90:1-15. Epub 2018 Oct 18.

Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Diabetes mellitus type 1 and type 2 have become a global epidemic with dramatically increasing incidences. Poorly controlled diabetes is associated with severe life-threatening complications. Beside traditional treatment with insulin and oral anti-diabetic drugs, clinicians try to improve patient's care by cell therapies using embryonic stem cells (ESC), induced pluripotent stem cells (iPSC) and adult mesenchymal stem cells (MSC). Read More

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January 2019
3 Reads

Effectiveness of artificial pancreas in the non-adult population: A systematic review and network meta-analysis.

Metabolism 2019 Jan 12;90:20-30. Epub 2018 Oct 12.

First Department of Cardiology, Biomedical Engineering Unit, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Objective: Artificial pancreas is a technology that minimizes user input by bridging continuous glucose monitoring and insulin pump treatment, and has proven safety in the adult population. The purpose of this systematic review and meta-analysis is to evaluate the efficacy of closed-loop (CL) systems in the glycemic control of non-adult type 1 diabetes patients in both a pairwise and network meta-analysis (NMA) context and investigate various parameters potentially affecting the outcome.

Methods: Literature was systematically searched using the MEDLINE (1966-2018), Scopus (2004-2018), Cochrane Central Register of Controlled Trials (CENTRAL) (1999-2018), Clinicaltrials. Read More

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January 2019
3 Reads

Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition.

Metabolism 2018 Nov 3;88:61-71. Epub 2018 Jul 3.

State Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, China; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China; Department of Basic Science of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China. Electronic address:

Objective: B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) deficiency (Bmi-1) leads to an osteoporotic phenotype with a significant downregulation of Sirt1 protein expression. Sirtuin 1 (Sirt1) haploinsufficiency results in a bone loss by decreased bone formation; however, it is unclear whether Sirt1 overexpression in mesenchymal stem cells (MSCs) plays an anti-osteoporotic role. The aim of the study is to identify whether the overexpression of Sirt1 in MSCs could restore skeletal growth retardation and osteoporosis in Bmi-1 deficient mice. Read More

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November 2018
2 Reads

PPARγ is a major regulator of branched-chain amino acid blood levels and catabolism in white and brown adipose tissues.

Metabolism 2018 Dec 11;89:27-38. Epub 2018 Oct 11.

Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address:

Objective: We investigated whether PPARγ modulates adipose tissue BCAA metabolism, and whether this mediates the attenuation of obesity-associated insulin resistance induced by pharmacological PPARγ activation.

Methods: Mice with adipocyte deletion of one or two PPARγ copies fed a chow diet and rats fed either chow, or high fat (HF) or HF supplemented with BCAA (HF/BCAA) diets treated with rosiglitazone (30 or 15 mg/kg/day, 14 days) were evaluated for glucose and BCAA homeostasis.

Results: Adipocyte deletion of one PPARγ copy increased mice serum BCAA and reduced inguinal white (iWAT) and brown (BAT) adipose tissue BCAA incorporation into triacylglycerol, as well as mRNA levels of branched-chain aminotransferase (BCAT)2 and branched-chain α-ketoacid dehydrogenase (BCKDH) complex subunits. Read More

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December 2018
2 Reads

Obesity-induced upregulation of miR-361-5p promotes hepatosteatosis through targeting Sirt1.

Metabolism 2018 Nov 14;88:31-39. Epub 2018 Sep 14.

Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. Electronic address:

Objective: Obesity is associated with an increased risk of many metabolic disorders, including non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanisms remain poorly understood. Recent studies have demonstrated that MicroRNA-mediated gene silencing plays an important role in hepatic triglyceride (TG) metabolism. Read More

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November 2018
5 Reads

TET2: Is a potential gatekeeper for the action of thiazolidinedione in fat cells?

Metabolism 2018 Dec 5;89:A1-A2. Epub 2018 Oct 5.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, United States of America. Electronic address:

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December 2018

Insights into pathogenesis of five novel GCK mutations identified in Chinese MODY patients.

Metabolism 2018 Dec 23;89:8-17. Epub 2018 Sep 23.

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

Objective: Heterozygous inactivating mutations in GCK are associated with defects in pancreatic insulin secretion and/or hepatic glycogen synthesis leading to mild chronic hyperglycaemia of maturity onset diabetes of young type 2 (MODY2). However, the effect of naturally occurring GCK mutations on the pathogenesis for MODY2 hyperglycaemia remains largely unclear, especially in the Asian population. The aim of this study is to explore the potential pathogenicity of novel GCK mutations related to MODY2. Read More

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December 2018
8 Reads

MicroRNAs and type 2 diabetes mellitus: Molecular mechanisms and the effect of antidiabetic drug treatment.

Metabolism 2018 Oct 3;87:48-55. Epub 2018 Jul 3.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

The incidence of type 2 diabetes mellitus (T2DM), the most prevalent metabolic disease, is rapidly growing worldwide. T2DM has several underlying causes involved in its development. In recent decades, there is compelling evidence demonstrating that microRNAs (miRs) are implicated in the pathophysiology of T2DM. Read More

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October 2018
2 Reads
3.890 Impact Factor

Obesity modifies the stoichiometry of mitochondrial proteins in a way that is distinct to the subcellular localization of the mitochondria in skeletal muscle.

Metabolism 2018 Dec 22;89:18-26. Epub 2018 Sep 22.

Center for Metabolic and Vascular Biology, Arizona State University, Scottsdale, AZ 85259, United States of America; College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, United States of America. Electronic address:

Background: Skeletal muscle mitochondrial content and function appear to be altered in obesity. Mitochondria in muscle are found in well-defined regions within cells, and they are arranged in a way that form distinct subpopulations of subsarcolemmal (SS) and intermyofibrillar (IMF) mitochondria. We sought to investigate differences in the proteomes of SS and IMF mitochondria between lean subjects and subjects with obesity. Read More

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December 2018

The epidemiology of obesity.

Metabolism 2018 Sep 22. Epub 2018 Sep 22.

Clinical Nutrition Research Centre (CNRC), Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), National University Health System, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore; Department of Nutrition, Exercise and Sports - Obesity Research, University of Copenhagen, Denmark. Electronic address:

Obesity is a complex multifactorial disease. The worldwide prevalence of overweight and obesity has doubled since 1980 to an extent that nearly a third of the world's population is now classified as overweight or obese. Obesity rates have increased in all ages and both sexes irrespective of geographical locality, ethnicity or socioeconomic status, although the prevalence of obesity is generally greater in older persons and women. Read More

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September 2018
10 Reads

A novel role for zinc transporter 8 in the facilitation of zinc accumulation and regulation of testosterone synthesis in Leydig cells of human and mouse testicles.

Metabolism 2018 Nov 17;88:40-50. Epub 2018 Sep 17.

School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address:

Objective: Zinc is intimately involved in testosterone production. Zinc transporter 8 (ZnT8) is found to be localized in insulin secretory granules as a β-cell specific Zn transporter. The effect of ZnT8 and related zinc accumulation in steroidogenesis, however, is still unknown. Read More

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November 2018

Limitations of platform assays to measure serum 25OHD level impact on guidelines and practice decision making.

Metabolism 2018 Dec 15;89:1-7. Epub 2018 Sep 15.

Department of Internal Medicine, Division of Endocrinology, Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Context: Liquid Chromatography Mass Spectroscopy (LC-MS/MS) is the preferred method to measure 25 hydroxyvitamin D (25OHD) levels, but laboratories are increasingly adopting automated platform assays.

Objective: We assessed the performance of commonly used automated immunoassays, with that of LC-MS/MS, and the National Institute of Standards and Technology (NIST) reference values, to measure 25OHD levels.

Methods/setting: We compared serum 25OHD levels obtained from 219 elderly subjects, enrolled in a vitamin D trial, using the Diasorin Liaison platform assay, and the tandem LC-MS/MS method. Read More

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December 2018
3 Reads

cGMP-dependent protein kinase I (cGKI) modulates human hepatic stellate cell activation.

Metabolism 2018 Nov 6;88:22-30. Epub 2018 Sep 6.

Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Otfried-Müller-Str 10, 72076 Tübingen, Germany; Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, University of Tübingen, Otfried-Müller-Str 10, 72076 Tübingen, Germany; German Center for Diabetes Research (DZD e.V.), Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.

Background: The activation of hepatic stellate cells (HSCs) plays a crucial role in liver fibrosis, however the role of HSCs is less understood in hepatic insulin resistance. Since in the liver cGMP-dependent protein kinase I (cGKI) was detected in HSC but not in hepatocytes, and cGKI-deficient mice that express cGKI selectively in smooth muscle but not in other cell types (cGKI-SM mice) displayed hepatic insulin resistance, we hypothesized that cGKI modulates HSC activation and insulin sensitivity.

Materials And Methods: To study stellate cell activation in cGKI-SM mice, retinol storage and gene expression were studied. Read More

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November 2018
4 Reads
1 PubMed Central Citation(source)
3.890 Impact Factor

TET2 facilitates PPARγ agonist-mediated gene regulation and insulin sensitization in adipocytes.

Metabolism 2018 Dec 5;89:39-47. Epub 2018 Sep 5.

Department of Nutritional Sciences and Toxicology, UC Berkeley, Berkeley, CA 94720, USA. Electronic address:

Emerging evidence indicates that epigenetic mechanisms like DNA methylation directly contribute to metabolic regulation. For example, we previously demonstrated that de novo DNA methyltransferase Dnmt3a plays a causal role in the development of adipocyte insulin resistance. Recent studies suggest that DNA demethylation plays an important role in the developmental process of adipocytes. Read More

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December 2018
3 Reads

Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic connexin 43.

Metabolism 2018 Nov 1;88:51-60. Epub 2018 Sep 1.

Department of Biomedical Science, Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea; Appetite Regulation Laboratory, Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea; Division of Endocrinology and Metabolism, Asan Medical Center, Seoul 05505, Republic of Korea. Electronic address:

Background: Nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 is an important regulator of hypothalamic neuronal function. Thus, an adequate hypothalamic NAD content is critical for maintaining normal energy homeostasis.

Methods: We investigated whether NAD supplementation increases hypothalamic NAD levels and affects energy metabolism in mice. Read More

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November 2018

Involvement of acetyl-CoA-producing enzymes in the deterioration of the functional potential of adipose-derived multipotent cells from subjects with metabolic syndrome.

Metabolism 2018 Nov 31;88:12-21. Epub 2018 Aug 31.

Department of Clinical Endocrinology and Nutrition, Institute of Biomedical Research of Málaga (IBIMA), Hospital of Málaga (Virgen de la Victoria), University of Málaga (UMA), Spain; Pathophysiology of Obesity and Nutrition, CIBEROBN, Institute of Health Carlos III, ISCIII, Spain. Electronic address:

Objective: The expansion capacity of white adipose tissue influences the distribution of fat depots in the body, the visceral accumulation of which is linked to metabolic syndrome, regardless of the degree of obesity of the subjects. Alterations in the adipose tissue-derived mesenchymal stem cells (ASCs) may contribute to the adipose tissue remodeling associated with metabolic syndrome and impact the regional distribution of adipose tissue by generating inherently dysfunctional adipocytes. Here we examine the expression levels of acetyl-CoA-producing enzymes and their relationship with the lipogenic, antioxidant and oxidative potential of adipocytes generated from visceral ASCs (adipo-visASCs) and subcutaneous ASCs (adipo-subASCs) from subjects with different metabolic profiles. Read More

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November 2018
1 Read
3.890 Impact Factor

Non-alcoholic fatty liver disease and colorectal cancer: A marker of risk or common causation?

Metabolism 2018 Oct 30;87:A10-A13. Epub 2018 Aug 30.

Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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October 2018
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Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice.

Metabolism 2018 Nov 8;88:1-11. Epub 2018 Aug 8.

Departamento de Ciencias de la Salud, Universidad de Burgos, Burgos, Spain. Electronic address:

The role of insulin-degrading enzyme (IDE), a metalloprotease with high affinity for insulin, in insulin clearance remains poorly understood.

Objective: This study aimed to clarify whether IDE is a major mediator of insulin clearance, and to define its role in the etiology of hepatic insulin resistance.

Methods: We generated mice with liver-specific deletion of Ide (L-IDE-KO) and assessed insulin clearance and action. Read More

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November 2018
2 Reads

Omics, big data and machine learning as tools to propel understanding of biological mechanisms and to discover novel diagnostics and therapeutics.

Metabolism 2018 Oct 8;87:A1-A9. Epub 2018 Aug 8.

Department of Endocrinology, VA Boston Healthcare System, Jamaica Plain, Boston, MA 02130, USA; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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October 2018
3 Reads

Sugar or fat: The metabolic choice of the trained heart.

Metabolism 2018 Oct 3;87:98-104. Epub 2018 Aug 3.

Unidade de Investigação Cardiovascular, Departamento de Cirurgia e Fisiologia, Faculdade de Medicina, Universidade do Porto, Porto, Portugal; CIAFEL, Faculty of Sport, University of Porto, Porto, Portugal. Electronic address:

Mammals respond to muscular exercise by increasing cardiac output to meet the increased demand for oxygen in the working muscles and it is well-established that regular bouts of exercise results in myocardial remodeling. Depending on exercise type, intensity and duration, these cardiac adaptations lead to changes in the energetic substrates required to sustain cardiac contractility. In contrast to the failing heart, fatty acids are the preferred substrate in the trained heart, though glucose metabolism is also enhanced to support oxidative phosphorylation. Read More

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October 2018
10 Reads

Sex-Biased Physiological Roles of NPFF1R, the Canonical Receptor of RFRP-3, in Food Intake and Metabolic Homeostasis Revealed by its Congenital Ablation in mice.

Metabolism 2018 Oct 31;87:87-97. Epub 2018 Jul 31.

Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Hospital Universitario Reina Sofia, Instituto de Salud Carlos III, 14004 Cordoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Cordoba, Spain; FiDiPro Program, Institute of Biomedicine, University of Turku, Turku, Finland. Electronic address:

Background: RF-amide-related peptide-3 (RFRP-3), the mammalian ortholog of gonadotropin-inhibiting hormone, operates as inhibitory signal for the reproductive axis. Recently, RFRP-3 has been also suggested to stimulate feeding, and therefore might contribute to the control of body weight and its alterations. Yet, characterization of the metabolic actions of RFRP-3 has been so far superficial and mostly pharmacological. Read More

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October 2018
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The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials.

Metabolism 2018 Oct 7;87:56-69. Epub 2018 Jul 7.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R., Iran. Electronic address:

Objective: This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to summarize the effect of alpha-lipoic acid (ALA) supplementation on glycemic control and lipid profiles among patients with metabolic diseases.

Methods: We searched the following databases till October 2017: MEDLINE, EMBASE, Web of Science and Cochrane Central Register of Controlled Trials. The relevant data were extracted and assessed for quality of the studies according to the Cochrane risk of bias tool. Read More

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October 2018
3 Reads

The prebiotic inulin improves substrate metabolism and promotes short-chain fatty acid production in overweight to obese men.

Metabolism 2018 Oct 25;87:25-35. Epub 2018 Jun 25.

Top Institute Food and Nutrition, Wageningen, the Netherlands; Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Universiteitssingel 50, 6229 ER Maastricht, the Netherlands. Electronic address:

Background And Aims: Human gut microbiota play an important role in maintaining human health. Dietary fibers, i.e. Read More

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October 2018
11 Reads

Potential impact of Helicobacter pylori-related metabolic syndrome on upper and lower gastrointestinal tract oncogenesis.

Metabolism 2018 Oct 21;87:18-24. Epub 2018 Jun 21.

Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Both Helicobacter pylori infection and metabolic syndrome present significant global public health burdens. Metabolic syndrome is closely related to insulin resistance, the major underlying mechanism responsible for metabolic abnormalities, and Helicobacter pylori infection has been proposed to be a contributing factor. There is growing evidence for a potential association between Helicobacter pylori infection and insulin resistance, metabolic syndrome and related morbidity, including abdominal obesity, type 2 diabetes mellitus, dyslipidemia, hypertension, all of which increase mortality related to cardio-cerebrovascular disease, neurodegenerative disorders, nonalcoholic fatty liver disease and malignancies. Read More

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October 2018
6 Reads

The OEA effect on food intake is independent from the presence of PPARα in the intestine and the nodose ganglion, while the impact of OEA on energy expenditure requires the presence of PPARα in mice.

Metabolism 2018 Oct 21;87:13-17. Epub 2018 Jun 21.

Laboratory of Metabolism, Department of Medicine Specialties, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Electronic address:

Background: Oleoylethanolamide (OEA) is an endocannabinoid that controls food intake, energy expenditure and locomotor activity. Its anorexigenic effect appears to be mediated by PPARα, but the tissue where the presence of this receptor is required for OEA to inhibit feeding is unknown as yet. Previous studies point to a possible role of proximal enterocytes and neurons of the nodose ganglion. Read More

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October 2018
2 Reads