12,713 results match your criteria Metabolism[Journal]


Corrigendum to "The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling" [Metab Clin Exp 85 (2018) 59-75].

Metabolism 2019 Apr 17. Epub 2019 Apr 17.

Pharmacology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2019.04.009DOI Listing

Lipoxygenase drives Lipidomic and metabolic reprogramming in ischemic heart failure.

Metabolism 2019 Apr 15. Epub 2019 Apr 15.

Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, AL, United States.

Background: After myocardial infarction (MI), delayed progression or reversal of cardiac remodeling is a prime target to limit advanced chronic heart failure (HF). However, the temporal kinetics of lipidomic and systemic metabolic signaling is unclear in HF. There is no consensus on metabolic and lipidomic signatures that influence structure, function, and survival in HF. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.04.011DOI Listing
April 2019
1 Read

Fatty acid binding protein 4 (FABP4) as a potential biomarker reflecting myocardial lipid storage in type 2 diabetes.

Metabolism 2019 Apr 15. Epub 2019 Apr 15.

Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, "Sant Joan" University Hospital, Universitat Rovira i Virgili, Institut de Investigació Sanitaria Pere Virgili (IISPV), Reus, Spain; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Institute of Health Carlos III, Madrid, Spain. Electronic address:

Objective: Fatty acid binding protein 4 (FABP4) is an intracellular lipid chaperone involved in the crosstalk between adipose and peripheral tissues, and it contributes to widespread insulin resistance in cells, including cardiac cells. However, the role of this adipokine in regulating cardiac metabolism and myocardial neutral lipid content in patients with type 2 diabetes has not been elucidated.

Methods: The impact of circulating FABP4 on the cardiac neutral lipid content were measured by proton magnetic resonance spectroscopy (H-MRS) in patients with type 2 diabetes. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.04.007DOI Listing
April 2019
1 Read

Fractional turnover of apolipoprotein(a) and apolipoprotein B-100 within plasma lipoprotein(a) particles in statin-treated patients with elevated and normal Lp(a) concentration.

Metabolism 2019 Apr 14. Epub 2019 Apr 14.

School of Medicine, University of Western Australia, Perth, Australia; Lipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, Australia. Electronic address:

Context: Lipoprotein(a) [Lp(a)] is a highly atherogenic lipoprotein characterized by apolipoprotein(a) [apo(a)] covalently bounded to apoB-100 (apoB). However, the metabolism of apo(a) and apoB within plasma Lp(a) particles in patients on statins remains unclear.

Methods: The kinetics of Lp(a)-apo(a) and Lp(a)-apoB were determined in 20 patients with elevated Lp(a) (≥0. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.04.010DOI Listing

Sodium-glucose co-transporter-2 inhibitors (SGLT2i) use and risk of amputation: an expert panel overview of the evidence.

Metabolism 2019 Apr 11. Epub 2019 Apr 11.

Beth-Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Section of Endocrinology, Boston VA Healthcare System, Harvard Medical School, Boston, MA, USA.

Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are oral antidiabetic agents that exert their glucose-lowering effect by increasing renal excretion of glucose. These drugs have been reported to beneficially affect cardiovascular (CV) and renal outcomes. However, concerns have recently been raised in relation to increased risk of lower-extremities amputation with canagliflozin and it remains unclear whether and to what extent this side effect could also occur with other SGLT2i. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.04.008DOI Listing

FOXO1 localizes to mitochondria of adipose tissue and is affected by nutrient stress.

Metabolism 2019 Apr 8. Epub 2019 Apr 8.

Dept. of Biology, University of Rome "Tor Vergata", Via della Ricerca Scientifica, 00133 Rome, Italy; IRCCS San Raffaele Roma, Via di Val Cannuta 247, 00166, Rome, Italy. Electronic address:

Objective: Mitochondria play pivotal roles in orchestrating signaling pathways in order to guarantee metabolic homeostasis under different stimuli. It has been demonstrated that the mito-nuclear communication is fundamental for facing physiological and/or stress-mediated cellular response through the activation of nuclear transcription factors. Here, we focused on the Forkhead box protein O1 (FoxO1) transcription factor that belongs to the FoxOs family proteins and is considered a "nutrients sensor" modulating the expression of nutrient-stress response genes. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.04.006DOI Listing
April 2019
2 Reads

ACC/AHA Lipids & ASCVD Guidelines: 2018 Update.

Authors:
Michael Miller

Metabolism 2019 Apr 8. Epub 2019 Apr 8.

Department of Medicine, Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, 21201. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2019.03.008DOI Listing

Characteristics of bile acids metabolism profile in the second and third trimesters of normal pregnancy.

Metabolism 2019 Apr 5. Epub 2019 Apr 5.

Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Clinical Prenatal Diagnosis Center, Women's Hospital, School of Medicine, Zhejiang University. Electronic address:

Purpose: Bile acids are a group of cholesterol metabolites functioning as key regulators of glucose, lipid, and energy metabolism. Their homeostatic control is essential to the physiology of the normal pregnancy. Abnormalities of bile acids regulation in pregnancy lead to intrahepatic cholestasis of pregnancy, a serious condition associated with a number of fetal and maternal morbidities. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.04.004DOI Listing
April 2019
2 Reads

Maternal, neonatal insulin resistance and neonatal anthropometrics in pregnancies following bariatric surgery.

Metabolism 2019 Apr 5. Epub 2019 Apr 5.

Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology, Institute of Reproductive and Developmental Biology, Chelsea and Westminster Hospital, Imperial College London, London, UK; Academic Department of Obstetrics and Gynaecology, Institute of Reproductive and Developmental Biology, Chelsea and Westminster Hospital, Imperial College London, London, UK. Electronic address:

Objective: An increasing number of women present pregnant having undergone bariatric surgery, a popular treatment for sustainable weight loss. The aim of the study was to investigate the effect, if any, of bariatric surgery on maternal and neonatal insulin resistance (IR) and neonatal body fat composition.

Methods: Maternal IR, at 28 weeks of gestation during 2-h 75 g oral glucose tolerance test (OGTT), neonatal IR, from umbilical cord venous blood, and neonatal birthweight and body fat composition (calculated by measuring skin folds) at birth were evaluated in 41 post-bariatric and 82 pregnant women with similar early pregnancy body mass index but no history of such surgery. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.04.005DOI Listing
April 2019
2 Reads

The effect of frequency of activity interruptions in prolonged sitting on postprandial glucose metabolism: a randomized crossover trial.

Metabolism 2019 Apr 4. Epub 2019 Apr 4.

The Centre of Inflammation and Metabolism (CIM) and the Centre for Physical Activity Research (CFAS), Rigshospitalet, University of Copenhagen, Denmark.

Objective: The primary objective was to test the hypothesis that increased frequency of interruptions in prolonged sitting reduces postprandial glycemia independent of energy intake and expenditure.

Materials/methods: Healthy, sedentary, centrally obese men (n = 14; age*, 28.2 (23. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.04.003DOI Listing

Alterations in the metabolism of phospholipids, bile acids and branched-chain amino acids predicts development of type 2 diabetes in black south African women: a prospective cohort study.

Metabolism 2019 Apr 4. Epub 2019 Apr 4.

Department of Public Health and Clinical Medicine, Umeå University, Sweden. Electronic address:

Background: South Africa (SA) has the highest global projected increase in diabetes risk. Factors typically associated with insulin resistance and type 2 diabetes risk in Caucasians are not significant correlates in black African populations. Therefore, we aimed to identify circulating metabolite patterns that predict type 2 diabetes development in this high-risk, yet understudied SA population. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.04.001DOI Listing
April 2019
1 Read

Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder.

Metabolism 2019 Apr 4. Epub 2019 Apr 4.

Institute of Clinical Pharmacology, Goethe-University Hospital Frankfurt, Germany. Electronic address:

Changes of sphingolipid metabolism were suggested to contribute to the patho-etiology of major depression (MD) and bipolar disorder (BD). In a pilot study we assessed if lipid allostasis manifested in pathological plasma concentrations of bioactive lipids i.e. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.04.002DOI Listing
April 2019
6 Reads

Chitinase-3-like-1 deficiency attenuates ethanol-induced liver injury by inhibition of sterol regulatory element binding protein 1-dependent triglyceride synthesis.

Metabolism 2019 Mar 29. Epub 2019 Mar 29.

College of Pharmacy and Medical Research Center, Chungbuk National University, Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, Chungbuk, 28160, Republic of Korea. Electronic address:

Objective: Alcohol overconsumption and abuse lead to alcoholic liver disease (ALD), which is a major chronic liver disease worldwide. Chitinase-3-like protein 1 (CHI3L1) have an important role in the pathogenesis of inflammatory disease. However, the role of CHI3L1 in ALD has not yet been reported. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.03.010DOI Listing
March 2019
3 Reads

Diagnosis, treatment-monitoring and follow-up of children and adolescents with X-linked hypophosphatemia (XLH).

Metabolism 2019 Mar 27. Epub 2019 Mar 27.

APHP, Endocrinology and Diabetology for Children, Bicêtre Paris Sud Hospital, Le Kremlin-Bicêtre, France; APHP, Reference Center for Rare Disorders of Calcium and Phosphate Metabolism, filière OSCAR, Paris, France; APHP, Platform of Expertise for Rare Disorders Paris-Sud, Bicêtre Paris Sud Hospital, Le Kremlin-Bicêtre, France.

Early diagnosis, optimal therapeutic management and regular follow up of children with X-linked hypophosphatemia (XLH) determine their long term outcomes and future quality of life. Biochemical screening of potentially affected newborns in familial cases and improving physician's knowledge on clinical signs, symptoms and biochemical characteristics of XLH for de novo cases should lead to earlier diagnosis and treatment initiation. The follow-up of children with XLH includes clinical, biochemical and radiological monitoring of treatment (efficacy and complications) and screening for XLH-related dental, neurosurgical, rheumatological, cardiovascular, renal and ENT complications. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.03.009DOI Listing
March 2019
2 Reads

Of mice and men: Why progress in the pharmacological management of obesity is slower than anticipated and what could be done about it?

Metabolism 2019 Mar 22. Epub 2019 Mar 22.

Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Section of Endocrinology, Boston VA Healthcare System, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2019.03.007DOI Listing

Angiotensin-(1-7), Adipokines and Inflammation: Inflammation and adipokines.

Metabolism 2019 Mar 21. Epub 2019 Mar 21.

Institute of Agricultural Sciences. Food Engineering College, Universidade Federal de Minas Gerais (UFMG); Montes Claros, Minas Gerais, Brazil; Laboratory of Health Science, Post Graduate Program in Health Sciences; Universidade Estadual de Montes Claros (UNIMONTES), Montes Claros, Minas Gerais, Brazil. Electronic address:

Nowadays the adipose tissue is recognized as one of the most critical endocrine organs releasing many adipokines that regulate metabolism, inflammation and body homeostasis. There are several described adipokines, including the Renin-Angiotensin System (RAS) components that are especially activated in some diseases with increased production of Angiotensin II and several pro-inflammatory hormones. On the other hand, RAS also expresses Angiotensin-(1-7), which is now recognized as the main peptide on counteracting Ang II effects. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.03.006DOI Listing
March 2019
3 Reads

Effects of liraglutide plus phentermine in adults with obesity following 1 year of treatment by liraglutide alone: A randomized placebo-controlled pilot trial.

Metabolism 2019 Mar 20. Epub 2019 Mar 20.

Perelman School of Medicine at the University of Pennsylvania, Department of Psychiatry, Center for Weight and Eating Disorders, Philadelphia, PA, United States of America; University of Pennsylvania School of Nursing, Department of Biobehavioral Health Sciences, Philadelphia, PA, United States of America.

Background: This pilot study evaluated whether adding phentermine to liraglutide would induce further weight loss in participants who had previously lost weight with liraglutide alone.

Subjects/methods: Participants were 45 adults with obesity (75.6% female, 55. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.03.005DOI Listing

SUMO-specific protease 2 mediates leptin-induced fatty acid oxidation in skeletal muscle.

Metabolism 2019 Mar 19. Epub 2019 Mar 19.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, College of Medicine, Seoul National University, Seoul, Republic of Korea. Electronic address:

Background And Purpose: In addition to the central nervous system-mediated action, leptin also directly induces fatty acid oxidation in skeletal muscle. Rapid induction of FAO by leptin is mediated by the AMP-activated protein kinase (AMPK) pathway, but the mechanism of prolonged FAO by leptin was previously unknown. In an earlier study, we showed that free fatty acids increase transcription of small ubiquitin-like modifier (SUMO) specific protease 2 (SENP2) in skeletal muscle, and that SENP2 stimulates expression of FAO-associated enzymes by deSUMOylating peroxisome proliferator-activated receptors, PPARδ and PPARγ. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.03.004DOI Listing

Epicardial fat: the role of testosterone and lipid metabolism in a cohort of patients with Klinefelter syndrome.

Metabolism 2019 Mar 13. Epub 2019 Mar 13.

Centre for Rare Diseases, Policlinico Umberto I, Rome, Italy; Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy.

Context: Klinefelter syndrome (KS), in which subjects have additional copies of X chromosomes, is the most common male sex chromosome abnormality, with a prevalence of 1 in 660 and an incidence of about 1 in 500-700 newborns. Its sign and symptoms include infertility, generally low testosterone levels, and an increased prevalence of obesity and metabolic syndrome. Epicardial fat thickness (EFT) reflects visceral adiposity rather than general obesity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495193005
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http://dx.doi.org/10.1016/j.metabol.2019.03.002DOI Listing
March 2019
7 Reads

Systemic PPARγ deletion in mice provokes lipoatrophy, organomegaly, severe type 2 diabetes and metabolic inflexibility.

Metabolism 2019 Mar 13. Epub 2019 Mar 13.

Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH-1015 Lausanne, Switzerland. Electronic address:

Background: The peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-dependent transcription factor involved in many aspects of metabolism, immune response and development. Numerous studies relying on tissue-specific invalidation of the Pparg gene have shown distinct facets of its activity, whereas the effects of its systemic inactivation remain unexplored due to embryonic lethality. By maintaining PPARγ expression in the placenta, we recently generated a mouse model carrying Pparg full body deletion (Pparg), which in contrast to a previously published model is totally deprived of any form of adipose tissue. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.03.003DOI Listing

GAD65 antibodies and incident type 2 Diabetes mellitus.

Metabolism 2019 Mar 7. Epub 2019 Mar 7.

Amsterdam UMC, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.

Context: Antibodies to the 65kD isoform of glutamic acid decarboxylase (GAD65) have been associated with incident Type 2 Diabetes Mellitus, however results are inconsistent.

Objective: To assess the association between GAD65 antibody positivity and incident Type 2 Diabetes Mellitus in a non-diabetic adult (≥18 years) population, in a systematic review and meta-analysis.

Data Sources: A systematic literature search was conducted in Pubmed (MEDLINE) and Embase until January 14th, 2019. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.03.001DOI Listing

PAQR3 modulates blood cholesterol level by facilitating interaction between LDLR and PCSK9.

Metabolism 2019 May 1;94:88-95. Epub 2019 Mar 1.

CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China; School of Life Sciences and Technology, Shanghai Tech University, Shanghai 200031, China. Electronic address:

Objective: Low-density lipoprotein cholesterol (LDL-C) is the hallmark of atherosclerotic cardiovascular diseases. The hepatic LDL receptor (LDLR) plays an important role in clearance of circulating LDL-C. PCSK9 facilitates degradation of LDLR in the lysosome and antagonizing PCSK9 has been successfully used in the clinic to reduce blood LDL-C level. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.02.005DOI Listing
May 2019
2 Reads
3.894 Impact Factor

Extracellular vesicles: Squeezing every drop of regenerative potential of umbilical cord blood.

Metabolism 2019 Mar 1. Epub 2019 Mar 1.

Servei de Teràpia Cel·lular, Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain; Musculoskeletal Tissue Engineering Group, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Passeig de la Vall d'Hebron 129-139, 08035 Barcelona, Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Passeig de la Vall d'Hebron 129-139, 08035 Barcelona, Spain. Electronic address:

Collection, cryopreservation and transplantation of umbilical cord blood (UCB)-derived cells have become a popular option for regenerative medicine, not limited to the transplantation of hematopoietic cell progenitors only. Indeed, increasing evidence shows that extracellular vesicles (EV), which include a heterogeneous pool of membranous structures secreted by the vast majority of cells, can serve as powerful tools for cell-free therapy due to precise multifunctional molecular cargoes. In this issue, Hu et al. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.02.006DOI Listing
March 2019
3 Reads

Association between obesity and biomarkers of inflammation and metabolism with cancer mortality in a prospective cohort study.

Metabolism 2019 May 23;94:69-76. Epub 2019 Feb 23.

Department of Epidemiology, University of Kentucky, Lexington, KY, USA; Markey Cancer Center, University of Kentucky, Lexington, KY, USA; Department of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA. Electronic address:

Objective: To investigate the association between biomarkers of inflammation and metabolic dysregulation and cancer mortality by obesity status.

Methods: Data from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort was used to examine the associations between baseline biomarkers of inflammation (IL-6, IL-8, IL-10, and CRP) and metabolism (adiponectin, resisting and lipoprotein (a)) with cancer mortality among 1822 participants cancer-free at baseline. Weighted Cox proportional hazard regression with the robust sandwich method was used to estimate the hazard ratios and 95% confidence intervals (CIs) adjusting for baseline covariates and stratified by BMI (normal, overweight/obese) given the significant interaction between biomarkers and BMI (p < 0. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.007DOI Listing

Beyond glycemic control: New guidance on cardio-renal protection.

Metabolism 2019 Feb 22. Epub 2019 Feb 22.

Section of Endocrinology, VA Boston Healthcare System, Jamaica, Plain, MA, USA; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00260495193004
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http://dx.doi.org/10.1016/j.metabol.2019.02.004DOI Listing
February 2019
4 Reads

Combination of exercise and calorie restriction exerts greater efficacy on cardioprotection than monotherapy in obese-insulin resistant rats through the improvement of cardiac calcium regulation.

Metabolism 2019 May 21;94:77-87. Epub 2019 Feb 21.

Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai 50200, Thailand; Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address:

Background: Long-term high-fat diet (HFD) consumption causes obese-insulin resistance which is known to be a major risk factor for cardiovascular diseases due to its impact on the impairment of left ventricular (LV) contractile function and cardiac mitochondrial function. Intracellular calcium [Ca]i regulation plays an important role in the maintenance of LV function. Although either caloric restriction (CR) or exercise (Ex) are shown to strongly affect metabolic status and LV function, the combined effects of exercise and calorie restriction on cardiometabolic status, cardiac mitochondrial dynamics and cardiac [Ca]i transient homeostasis under conditions of obese-insulin resistance have never been investigated. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.02.003DOI Listing
May 2019
1 Read

Role of PCSK9 in lipid metabolic disorders and ovarian dysfunction in polycystic ovary syndrome.

Metabolism 2019 May 12;94:47-58. Epub 2019 Feb 12.

Department of Physiology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, Chengdu, China. Electronic address:

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a critical role in the cholesterol metabolism by negatively regulating the low-density lipoprotein receptor (LDLR). Lipid metabolic and ovarian disorders are the common clinical manifestation of polycystic ovary syndrome (PCOS). Here, we intended to elucidate the role of PCSK9 in the pathogenesis of PCOS conducted on a human population in case-control design and animal part in an interventional study. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.02.002DOI Listing
May 2019
2 Reads

A novel GTPCH deficiency mouse model exhibiting tetrahydrobiopterin-related metabolic disturbance and infancy-onset motor impairments.

Metabolism 2019 May 10;94:96-104. Epub 2019 Feb 10.

Department of Genetics and Endocrine, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China. Electronic address:

Background: GTP cyclohydrolase I (GTPCH) deficiency could impair the synthesis of tetrahydrobiopterin and causes metabolic diseases involving phenylalanine catabolism, neurotransmitter synthesis, nitric oxide production and so on. Though improvements could be achieved by tetrahydrobiopterin and neurotransmitter precursor levodopa supplementation, residual motor and mental deficits remain in some patients. An appropriate GTPCH deficiency animal model with clinical symptoms, especially the motor impairments, is still not available for mechanism and therapy studies yet. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.02.001DOI Listing
May 2019
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Effects of isolated soy protein and strength exercise training on exercise performance and biochemical profile in postpartum mice.

Metabolism 2019 May 5;94:18-27. Epub 2019 Feb 5.

Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan. Electronic address:

Objective: Postpartum women are at an increased risk for obesity and metabolic diseases because of excessive weight gain during pregnancy and weight retention after delivery. Maintenance of good nutrition and regular physical activity is used as a therapeutic approach for promotion of health and well-being in postpartum women. The aim of this study is to assess the independent and additive effects of isolated soy protein (ISP) and strength exercise training (ET) on weight management, exercise performance and health maintenance in postpartum mice. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.012DOI Listing
May 2019
1 Read
3.894 Impact Factor

The tRNA-associated dysregulation in diabetes mellitus.

Metabolism 2019 May 1;94:9-17. Epub 2019 Feb 1.

Department of Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China. Electronic address:

Diabetes mellitus (DM) is a complex endocrine and metabolic disorder for human health and well-being. Deregulated glucose and lipid metabolism are the primary underlying manifestations associated with this disease. Transfer RNAs (tRNAs) are considered to mainly participate in protein translation and may contribute to complex human pathologies. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.017DOI Listing

LncRNA MEG3 functions as a ceRNA in regulating hepatic lipogenesis by competitively binding to miR-21 with LRP6.

Metabolism 2019 May 1;94:1-8. Epub 2019 Feb 1.

Emergency Department, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha 410013, China. Electronic address:

Background: Hepatic lipogenesis dysregulation is essential for the development of non-alcoholic fatty liver disease (NAFLD). Emerging evidence indicates the importance of the involvement of long non-coding RNAs (LncRNAs) in lipogenesis. However, the specific mechanism underlying this process is not clear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495193003
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http://dx.doi.org/10.1016/j.metabol.2019.01.018DOI Listing
May 2019
19 Reads

A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity.

Metabolism 2019 May 30;94:28-38. Epub 2019 Jan 30.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA; Departments of Medicine and Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

Background: Long-lived individuals and their offspring have healthier metabolic characteristics than expected, such as more favorable levels of fasting glucose, insulin, and lipids than controls without longevity. Dysregulation in metabolic pathways has also shown to predict accelerated aging. Using information from the Long Life Family Study (LLFS), a multi-center study of two-generation families selected for exceptional longevity, we developed an indicator of healthy metabolism to determine whether metabolic health was more prevalent in a subset of LLFS families and whether it was heritable and associated with other metrics of healthy aging. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.010DOI Listing
May 2019
1 Read

Inflammation and ER stress differentially regulate STAMP2 expression and localization in adipocytes.

Metabolism 2019 Apr 30;93:75-85. Epub 2019 Jan 30.

Department of Biosciences, University of Oslo, Postboks 1066 Blindern, 0316 Oslo, Norway; Institute for Cancer Genetics and Informatics, Oslo University Hospital, 0310 Oslo, Norway. Electronic address:

Background: Chronic ER stress and dysfunction is a hallmark of obesity and a critical contributor to metaflammation, abnormal hormone action and altered substrate metabolism in metabolic tissues, such as liver and adipocytes. Lack of STAMP2 in lean mice induces inflammation and insulin resistance on a regular diet, and it is dysregulated in the adipose tissue of obese mice and humans. We hypothesized that the regulation of STAMP2 is disrupted by ER stress. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460919PMC
April 2019
1 Read

Core body temperature, energy expenditure, and epinephrine during fasting, eucaloric feeding, and overfeeding in healthy adult men: evidence for a ceiling effect for human thermogenic response to diet.

Metabolism 2019 May 31;94:59-68. Epub 2019 Jan 31.

Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, 2412 N. 16th St, Phoenix, AZ 85016, USA. Electronic address:

Background: In homeothermic animals, approximately 50% of daily energy expenditure (EE) is spent to maintain a consistent core body temperature (CBT). In humans, little is known about CBT responses to feeding and overfeeding and their relationship to diet-related changes in EE.

Objective: To study the effects of feeding and overfeeding on CBT and its association with diet-induced thermogenesis (DIT). Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446552PMC
May 2019
1 Read

Diagnosis of disorders of glucose tolerance in women with polycystic ovary syndrome (PCOS) at a tertiary care center: fasting plasma glucose or oral glucose tolerance test?

Metabolism 2019 Apr 30;93:86-92. Epub 2019 Jan 30.

Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramón y Cajal & Universidad de Alcalá & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) & Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, 28034, Spain. Electronic address:

Background: The risk of developing prediabetes and type 2 diabetes (dysglycemia) may be increased in women with PCOS. Whether an oral glucose tolerance test (OGTT) should be performed routinely in all PCOS women at presentation or should be recommended only to a selected subset of patients is still controversial.

Basic Procedures: At a tertiary care center, we conducted a retrospective, observational study including 400 women with PCOS submitted to an OGTT. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.015DOI Listing
April 2019
4 Reads

Handgrip strength is inversely associated with metabolic syndrome and its separate components in middle aged and older adults: a large-scale population-based study.

Metabolism 2019 Apr 25;93:61-67. Epub 2019 Jan 25.

Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China; Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health; Center for International Collaborative Research on Environment, Nutrition and Public Health. Electronic address:

Background: Muscle weakness is followed by insulin resistance which is associated with metabolic disorders leading to metabolic syndrome (MetS). Therefore, muscle strength decline may be associated with MetS. The aim of this study was to investigate the relationships between muscle strength and MetS and its separate components. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495193002
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http://dx.doi.org/10.1016/j.metabol.2019.01.011DOI Listing
April 2019
10 Reads

Irisin: good or bad for the bone? A new path forward after the reported discovery of irisin receptor?

Metabolism 2019 Apr 25;93:100-102. Epub 2019 Jan 25.

Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.metabol.2019.01.013DOI Listing
April 2019
3 Reads

Extracellular vesicles from human umbilical cord blood ameliorate bone loss in senile osteoporotic mice.

Metabolism 2019 Jan 19. Epub 2019 Jan 19.

Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Hunan Key Laboratory of Organ Injury, Aging and Regenerative Medicine, Changsha, Hunan 410008, China; Hunan Key Laboratory of Bone Joint Degeneration and Injury, Changsha, Hunan 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Electronic address:

Objective: Senile osteoporosis is one of the most common age-related diseases worldwide. Accumulating evidences have indicated that young blood can reverse age-related impairments. Extracellular vesicles (EVs) exert therapeutic effects in a variety of diseases by delivering bioactive molecules such as microRNAs (miRNAs). Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.009DOI Listing
January 2019
2 Reads

Physiology of FGF23 and overview of genetic diseases associated with renal phosphate wasting.

Metabolism 2019 Jan 19. Epub 2019 Jan 19.

Paris Descartes University of Medicine, Necker-Enfants Malades Institute, INSERM U1151, France; Functional Exploration Department, Necker-Enfants Malades Hospital, AP-HP, Paris, France.

Phosphate is a cornerstone of several physiological pathways including skeletal development, bone mineralization, membrane composition, nucleotide structure, maintenance of plasma pH, and cellular signaling. The kidneys have a key role in phosphate homeostasis with three hormones having important functions in renal phosphate handling or intestinal absorption: parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and 1-25-dihydroxyvitamin D (1,25(OH)2D). FGF23 is mainly synthesized by osteocytes; it is a direct phosphaturic factor that also inhibits 1,25(OH)2D and PTH. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.006DOI Listing
January 2019
32 Reads

Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis.

Metabolism 2019 Apr 19;93:33-43. Epub 2019 Jan 19.

Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA; Diabetes Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA. Electronic address:

Background: CEACAM1 regulates insulin sensitivity by promoting insulin clearance. Accordingly, global C57BL/6J.Cc1 null mice display hyperinsulinemia due to impaired insulin clearance at 2 months of age, followed by insulin resistance, steatohepatitis, visceral obesity and leptin resistance at 6 months. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401268PMC
April 2019
3 Reads

Fibroblast growth factor 21: A role in cardiometabolic disorders and cardiovascular risk prediction?

Metabolism 2019 Apr 16;93:iii-v. Epub 2019 Jan 16.

Metabolism, Clinical and Experimental and Beth-Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States of America.

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http://dx.doi.org/10.1016/j.metabol.2019.01.005DOI Listing
April 2019
1 Read

Duodenal-jejunal lining increases postprandial unconjugated bile acid responses and disrupts the bile acid-FXR-FGF19 axis in humans.

Metabolism 2019 Apr 15;93:25-32. Epub 2019 Jan 15.

Amsterdam UMC, University of Amsterdam, Department of Endocrinology and Metabolism, Amsterdam Gastroenterology & Metabolism Research Institute, Meibergdreef 9, Amsterdam, the Netherlands. Electronic address:

Background And Aims: Placement of the duodenal-jejunal bypass liner (DJBL) leads to rapid weight loss and restoration of insulin sensitivity in a similar fashion to bariatric surgery. Increased systemic bile acid levels are candidate effectors for these effects through postprandial activation of their receptors TGR5 and FXR. We aimed to quantify postprandial bile acid, GLP-1 and FGF19 responses and assess their temporal relation to the weight loss and metabolic and hormonal changes seen after DJBL placement. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.12.009DOI Listing
April 2019
12 Reads

Does metformin therapy influence the effects of intensive lifestyle intervention? Exploring the interaction between first line therapies in the Look AHEAD trial.

Metabolism 2019 May 14;94:39-46. Epub 2019 Jan 14.

Faculty of Kinesiology, Sport, and Recreation, and Alberta Diabetes Institute, University of Alberta, 1-052 Li Ka Shing Centre for Health Research Innovation, Edmonton, AB T6G 2E1, Canada. Electronic address:

Aims: Metformin and lifestyle intervention are frequently prescribed together as first-line treatments for type 2 diabetes. However, little is known about their interplay. We investigated if the effects of a lifestyle intervention on glycemia, body mass and cardiorespiratory fitness (CRF) were influenced by metformin therapy. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.004DOI Listing
May 2019
2 Reads

Transition from metabolically benign to metabolically unhealthy obesity and 10-year cardiovascular disease incidence: The ATTICA cohort study.

Metabolism 2019 Apr 11;93:18-24. Epub 2019 Jan 11.

First Cardiology Clinic, School of Medicine, University of Athens, Greece.

Background/objectives: Metabolically benign obesity remains a scientific field of considerable debate. The aim of the present work was to evaluate whether metabolically healthy obese (MHO) status is a transient condition which propagates 10-year cardiovascular disease (CVD) onset.

Methods: A prospective longitudinal study was conducted during 2001-2012, the ATTICA study studying 1514 (49. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.003DOI Listing
April 2019
3 Reads
3.894 Impact Factor

A low resting metabolic rate in late childhood is associated with weight gain in adolescence.

Metabolism 2019 Apr 9;93:68-74. Epub 2019 Jan 9.

Phoenix Epidemiology and Clinical Research Branch, 4212 N 16th Street, Phoenix, AZ 85016, United States of America.

Background And Objectives: Lower total energy expenditure (TEE) and resting metabolic rate (RMR) are associated with greater weight gain in Native American adults. Whether these effects exist in childhood is unclear. We hypothesized that lower energy expenditure measured in childhood would predict greater relative change in body mass index (BMI) during adolescence. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407417PMC

The pathogenesis of obesity.

Metabolism 2019 Mar 9;92:26-36. Epub 2019 Jan 9.

Department of Endocrinology and Metabolism, Amsterdam University Medical Centers, location Academic Medical Center, Amsterdam, the Netherlands. Electronic address:

Body fat mass increases when energy intake exceeds energy expenditure. In the long term, a positive energy balance will result in obesity. The worldwide prevalence of obesity has increased dramatically, posing a serious threat to human health. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.12.012DOI Listing

Dietary modifications for weight loss and weight loss maintenance.

Metabolism 2019 Mar 6;92:153-162. Epub 2019 Jan 6.

Department of Nutrition and Dietetics, Harokopio University of Athens, Greece.

Worldwide obesity rates remain at a rise, and to treat obesity is at the top of the global public health agenda. In 2013, the AHA/ACC/TOS obesity management guidelines were published, in essence suggesting that any dietary scheme seems to be effective for weight loss, as long as it can induce a sustainable energy deficit. In the present review, we update and critically discuss available information regarding dietary modifications for weight loss and weight loss maintenance, published after the 2013 guidelines. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.001DOI Listing
March 2019
2 Reads

Obesity: seize the day, fight the fat.

Metabolism 2019 Mar 6;92:1-5. Epub 2019 Jan 6.

Metabolism, Clinical and Experimental, Harvard Medical School, Boston, MA 02215, USA; Section of Endocrinology, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2018.12.011DOI Listing

Vitamin D supplementation in obesity and during weight loss: A review of randomized controlled trials.

Metabolism 2019 Mar 4;92:193-205. Epub 2019 Jan 4.

Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, Division of Endocrinology and Metabolism, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Vitamin D deficiency is common in obese individuals and during weight loss. The recommended vitamin D doses in this specific population are higher than for healthy adults. We reviewed vitamin D supplementation trials in obesity, and during medical or surgical weight loss, and report the effects on 25-hydroxyvitamin D [25(OH)D] concentrations and other relevant outcomes. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.12.010DOI Listing
March 2019
3 Reads

Specific PERK inhibitors enhanced glucose-stimulated insulin secretion in a mouse model of type 2 diabetes.

Metabolism 2019 Jan 4. Epub 2019 Jan 4.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Innovative Research Institute for Cell Therapy, Seoul 03080, Republic of Korea. Electronic address:

Background: We have reported that partial PERK attenuation using PERK inhibitors (PI) enhanced glucose-stimulated insulin secretion (GSIS) from pancreatic islets and mice through induction of ER chaperone BIP. Therefore, we investigated if PI would have the same effects in a diabetic condition as well.

Methods: GSK2606414 was treated to mouse islets under 20-mM glucose and 0. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.12.007DOI Listing
January 2019
1 Read