12,686 results match your criteria Metabolism[Journal]


A novel GTPCH deficiency mouse model exhibiting tetrahydrobiopterin-related metabolic disturbance and infancy-onset motor impairments.

Metabolism 2019 Feb 8. Epub 2019 Feb 8.

Department of Genetics and Endocrine, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, China. Electronic address:

Background: GTP cyclohydrolase I (GTPCH) deficiency could impair the synthesis of tetrahydrobiopterin and causes metabolic diseases involving phenylalanine catabolism, neurotransmitter synthesis, nitric oxide production and so on. Though improvements could be achieved by tetrahydrobiopterin and neurotransmitter precursor levodopa supplementation, residual motor and mental deficits remain in some patients. An appropriate GTPCH deficiency animal model with clinical symptoms, especially the motor impairments, is still not available for mechanism and therapy studies yet. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.02.001DOI Listing
February 2019

Effects of isolated soy protein and strength exercise training on exercise performance and biochemical profile in postpartum mice.

Metabolism 2019 Feb 4. Epub 2019 Feb 4.

Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan. Electronic address:

Objective: Postpartum women are at an increased risk for obesity and metabolic diseases because of excessive weight gain during pregnancy and weight retention after delivery. Maintenance of good nutrition and regular physical activity is used as a therapeutic approach for promotion of health and well-being in postpartum women. The aim of this study is to assess the independent and additive effects of isolated soy protein (ISP) and strength exercise training (ET) on weight management, exercise performance and health maintenance in postpartum mice. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.012DOI Listing
February 2019
1 Read
3.894 Impact Factor

The tRNA-associated dysregulation in diabetes mellitus.

Metabolism 2019 Jan 31. Epub 2019 Jan 31.

Department of Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China. Electronic address:

Diabetes mellitus (DM) is a complex endocrine and metabolic disorder for human health and well-being. Deregulated glucose and lipid metabolism are the primary underlying manifestations associated with this disease. Transfer RNAs (tRNAs) are considered to mainly participate in protein translation and may contribute to complex human pathologies. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.017DOI Listing
January 2019

LncRNA MEG3 functions as a ceRNA in regulating hepatic lipogenesis by competitively binding to miR-21 with LRP6.

Metabolism 2019 Jan 31. Epub 2019 Jan 31.

Emergency Department, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha 410013, China. Electronic address:

Background: Hepatic lipogenesis dysregulation is essential for the development of non-alcoholic fatty liver disease (NAFLD). Emerging evidence indicates the importance of the involvement of long non-coding RNAs (LncRNAs) in lipogenesis. However, the specific mechanism underlying this process is not clear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495193003
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http://dx.doi.org/10.1016/j.metabol.2019.01.018DOI Listing
January 2019
8 Reads

A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity.

Metabolism 2019 Jan 30. Epub 2019 Jan 30.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA; Departments of Medicine and Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

Background: Long-lived individuals and their offspring have healthier metabolic characteristics than expected, such as more favorable levels of fasting glucose, insulin, and lipids than controls without longevity. Dysregulation in metabolic pathways have also shown to predict accelerated aging. Using information from the Long Life Family Study (LLFS), a multi-center study of two-generation families selected for exceptional longevity, we developed an indicator of healthy metabolism to determine whether metabolic health was more prevalent in a subset of LLFS families and whether it was heritable and associated with other metrics of healthy aging. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.010DOI Listing
January 2019

Inflammation and ER stress differentially regulate STAMP2 expression and localization in adipocytes.

Metabolism 2019 Jan 30. Epub 2019 Jan 30.

Department of Biosciences, University of Oslo, Postboks 1066 Blindern, 0316 Oslo, Norway; Institute for Cancer Genetics and Informatics, Oslo University Hospital, 0310 Oslo, Norway. Electronic address:

Background: Chronic ER stress and dysfunction is a hallmark of obesity and a critical contributor to metaflammation, abnormal hormone action and altered substrate metabolism in metabolic tissues, such as liver and adipocytes. Lack of STAMP2 in lean mice induces inflammation and insulin resistance on a regular diet, and it is dysregulated in the adipose tissue of obese mice and humans. We hypothesized that the regulation of STAMP2 is disrupted by ER stress. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.014DOI Listing
January 2019

Core body temperature, energy expenditure, and epinephrine during fasting, eucaloric feeding, and overfeeding in healthy adult men: evidence for a ceiling effect for human thermogenic response to diet.

Metabolism 2019 Jan 30. Epub 2019 Jan 30.

Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, 2412 N. 16th St, Phoenix, AZ, USA, 85016. Electronic address:

Background: In homeothermic animals, approximately 50% of daily energy expenditure (EE) is spent to maintain a consistent core body temperature (CBT). In humans, little is known about CBT responses to feeding and overfeeding and their relationship to diet-related changes in EE.

Objective: To study the effects of feeding and overfeeding on CBT and its association with diet-induced thermogenesis (DIT). Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.016DOI Listing
January 2019

Diagnosis of disorders of glucose tolerance in women with polycystic ovary syndrome (PCOS) at a tertiary care center: fasting plasma glucose or oral glucose tolerance test?

Metabolism 2019 Jan 30. Epub 2019 Jan 30.

Diabetes, Obesity and Hum Reprod Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramón y Cajal & Universidad de Alcalá & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) & Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, 28034, Spain. Electronic address:

Background: The risk of developing prediabetes and type 2 diabetes (dysglycemia) may be increased in women with PCOS. Whether an oral glucose tolerance test (OGTT) should be performed routinely in all PCOS women at presentation or should be recommended only to a selected subset of patients is still controversial.

Basic Procedures: At a tertiary care center, we conducted a retrospective, observational study including 400 women with PCOS submitted to an OGTT. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.015DOI Listing
January 2019
3 Reads

Handgrip strength is inversely associated with metabolic syndrome and its separate components in middle aged and older adults: a large-scale population-based study.

Metabolism 2019 Jan 25. Epub 2019 Jan 25.

Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China; Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China. Electronic address:

Background: Muscle weakness is followed by insulin resistance which is associated with metabolic disorders leading to metabolic syndrome (MetS). Therefore, muscle strength decline may be associated with MetS. The aim of this study was to investigate the relationships between muscle strength and MetS and its separate components. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495193002
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http://dx.doi.org/10.1016/j.metabol.2019.01.011DOI Listing
January 2019
3 Reads

Irisin: good or bad for the bone? A new path forward after the reported discovery of irisin receptor?

Metabolism 2019 Jan 25. Epub 2019 Jan 25.

Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.metabol.2019.01.013DOI Listing
January 2019
1 Read

Extracellular vesicles from human umbilical cord blood ameliorate bone loss in senile osteoporotic mice.

Metabolism 2019 Jan 19. Epub 2019 Jan 19.

Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Hunan Key Laboratory of Organ Injury, Aging and Regenerative Medicine, Changsha, Hunan 410008, China; Hunan Key Laboratory of Bone Joint Degeneration and Injury, Changsha, Hunan 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Electronic address:

Objective: Senile osteoporosis is one of the most common age-related diseases worldwide. Accumulating evidences have indicated that young blood can reverse age-related impairments. Extracellular vesicles (EVs) exert therapeutic effects in a variety of diseases by delivering bioactive molecules such as microRNAs (miRNAs). Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.009DOI Listing
January 2019

Physiology of FGF23 and overview of genetic diseases associated with renal phosphate wasting.

Metabolism 2019 Jan 19. Epub 2019 Jan 19.

Paris Descartes University of Medicine, Necker-Enfants Malades Institute, INSERM U1151, France; Functional Exploration Department, Necker-Enfants Malades Hospital, AP-HP, Paris, France.

Phosphate is a cornerstone of several physiological pathways including skeletal development, bone mineralization, membrane composition, nucleotide structure, maintenance of plasma pH, and cellular signaling. The kidneys have a key role in phosphate homeostasis with three hormones having important functions in renal phosphate handling or intestinal absorption: parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and 1-25-dihydroxyvitamin D (1,25(OH)2D). FGF23 is mainly synthesized by osteocytes; it is a direct phosphaturic factor that also inhibits 1,25(OH)2D and PTH. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495193002
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http://dx.doi.org/10.1016/j.metabol.2019.01.006DOI Listing
January 2019
11 Reads

Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis.

Metabolism 2019 Jan 18. Epub 2019 Jan 18.

Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA; Diabetes Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA. Electronic address:

Background: CEACAM1 regulates insulin sensitivity by promoting insulin clearance. Accordingly, global C57BL/6J.Cc1 null mice display hyperinsulinemia due to impaired insulin clearance at 2 months of age, followed by insulin resistance, steatohepatitis, visceral obesity and leptin resistance at 6 months. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.008DOI Listing
January 2019
2 Reads

Fibroblast growth factor 21: A role in cardiometabolic disorders and cardiovascular risk prediction?

Metabolism 2019 Jan 16. Epub 2019 Jan 16.

Metabolism, Clinical and Experimental and Beth-Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States of America.

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http://dx.doi.org/10.1016/j.metabol.2019.01.005DOI Listing
January 2019
1 Read

Duodenal-jejunal lining increases postprandial unconjugated bile acid responses and disrupts the bile acid-FXR-FGF19 axis in humans.

Metabolism 2019 Jan 15. Epub 2019 Jan 15.

Amsterdam UMC, University of Amsterdam, department of Endocrinology and Metabolism, Amsterdam Gastroenterology & Metabolism research institute, Meibergdreef 9, Amsterdam, the Netherlands. Electronic address:

Background And Aims: Placement of the duodenal-jejunal bypass liner (DJBL) leads to rapid weight loss and restoration of insulin sensitivity in a similar fashion to bariatric surgery. Increased systemic bile acid levels are candidate effectors for these effects through postprandial activation of their receptors TGR5 and FXR. We aimed to quantify postprandial bile acid, GLP-1 and FGF19 responses and assess their temporal relation to the weight loss and metabolic and hormonal changes seen after DJBL placement. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495193000
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http://dx.doi.org/10.1016/j.metabol.2018.12.009DOI Listing
January 2019
6 Reads

Does metformin therapy influence the effects of intensive lifestyle intervention? Exploring the interaction between first line therapies in the look AHEAD trial.

Metabolism 2019 Jan 14. Epub 2019 Jan 14.

Faculty of Kinesiology, Sport, and Recreation, 1-052 Li Ka Shing Centre for Health Research Innovation, Edmonton, AB, Canada T6G 2E1. Electronic address:

Aims: Metformin and lifestyle intervention are frequently prescribed together as first-line treatments for type 2 diabetes. However, little is known about their interplay. We investigated if the effects of a lifestyle intervention on glycemia, body mass and cardiorespiratory fitness (CRF) were influenced by metformin therapy. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.004DOI Listing
January 2019
2 Reads

Transition from metabolically benign to metabolically unhealthy obesity and 10-year cardiovascular disease incidence: the ATTICA cohort study.

Metabolism 2019 Jan 10. Epub 2019 Jan 10.

First Cardiology Clinic, School of Medicine, University of Athens, Greece.

Background/objectives: Metabolically benign obesity remains a scientific field of considerable debate.The aim of the present work was to evaluate whether metabolically healthy obese (MHO) status is a transient condition which propagates 10-year cardiovascular disease (CVD) onset.

Methods: A prospective longitudinal study was conducted during 2001-2012, the ATTICA study studying 1514 (49. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495193001
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http://dx.doi.org/10.1016/j.metabol.2019.01.003DOI Listing
January 2019
2 Reads
3.894 Impact Factor

A low resting metabolic rate in late childhood is associated with weight gain in adolescence.

Metabolism 2019 Jan 9. Epub 2019 Jan 9.

Phoenix Epidemiology and Clinical Research Branch, 4212 N 16(th) Street, Phoenix, AZ 85016, United States of America.

Background And Objectives: Lower total energy expenditure (TEE) and resting metabolic rate (RMR) are associated with greater weight gain in Native American adults. Whether these effects exist in childhood is unclear. We hypothesized that lower energy expenditure measured in childhood would predict greater relative change in body mass index (BMI) during adolescence. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.12.008DOI Listing
January 2019

The pathogenesis of obesity.

Metabolism 2019 Mar 9;92:26-36. Epub 2019 Jan 9.

Department of Endocrinology and Metabolism, Amsterdam University Medical Centers, location Academic Medical Center, Amsterdam, the Netherlands. Electronic address:

Body fat mass increases when energy intake exceeds energy expenditure. In the long term, a positive energy balance will result in obesity. The worldwide prevalence of obesity has increased dramatically, posing a serious threat to human health. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.12.012DOI Listing

Dietary modifications for weight loss and weight loss maintenance.

Metabolism 2019 Mar 6;92:153-162. Epub 2019 Jan 6.

Department of Nutrition and Dietetics, Harokopio University of Athens, Greece.

Worldwide obesity rates remain at a rise, and to treat obesity is at the top of the global public health agenda. In 2013, the AHA/ACC/TOS obesity management guidelines were published, in essence suggesting that any dietary scheme seems to be effective for weight loss, as long as it can induce a sustainable energy deficit. In the present review, we update and critically discuss available information regarding dietary modifications for weight loss and weight loss maintenance, published after the 2013 guidelines. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495193000
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http://dx.doi.org/10.1016/j.metabol.2019.01.001DOI Listing
March 2019
2 Reads

Obesity: seize the day, fight the fat.

Metabolism 2019 Mar 6;92:1-5. Epub 2019 Jan 6.

Metabolism, Clinical and Experimental, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2018.12.011DOI Listing

Vitamin D supplementation in obesity and during weight loss: A review of randomized controlled trials.

Metabolism 2019 Mar 4;92:193-205. Epub 2019 Jan 4.

Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, Division of Endocrinology and Metabolism, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Vitamin D deficiency is common in obese individuals and during weight loss. The recommended vitamin D doses in this specific population are higher than for healthy adults. We reviewed vitamin D supplementation trials in obesity, and during medical or surgical weight loss, and report the effects on 25-hydroxyvitamin D [25(OH)D] concentrations and other relevant outcomes. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.12.010DOI Listing

Specific PERK inhibitors enhanced glucose-stimulated insulin secretion in a mouse model of type 2 diabetes.

Metabolism 2019 Jan 4. Epub 2019 Jan 4.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea; Innovative Research Institute for Cell Therapy, Seoul, 03080, Republic of Korea. Electronic address:

Background: We have reported that partial PERK attenuation using PERK inhibitors (PI) enhanced glucose-stimulated insulin secretion (GSIS) from pancreatic islets and mice through induction of ER chaperone BIP. Therefore, we investigated if PI would have the same effects in a diabetic condition as well.

Methods: GSK2606414 was treated to mouse islets under 20-mM glucose and 0. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.12.007DOI Listing
January 2019
1 Read

Effects of alternate day fasting and exercise on cholesterol metabolism in overweight or obese adults: a pilot randomized controlled trial.

Metabolism 2019 Jan 4. Epub 2019 Jan 4.

Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Republic of Korea. Electronic address:

Background And Purpose: The objective of this pilot randomized controlled trial was to investigate the effect of alternate day fasting (ADF) and exercise on serum sterol signatures, which are surrogate markers of cholesterol absorption and biosynthesis.

Methods: We randomly assigned 112 overweight or obese participants to four groups: 1) ADF and exercise (E-ADF); 2) ADF; 3) exercise; and 4) control. We studied 31 completers in this exploratory analysis and measured their serum sterol signatures using gas chromatography-mass spectrometry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495193000
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http://dx.doi.org/10.1016/j.metabol.2019.01.002DOI Listing
January 2019
4 Reads
3.894 Impact Factor

Contribution of endogenous glucagon-like Peptide-1 to changes in glucose metabolism and islet function in people with type 2 diabetes four weeks after roux-en-Y gastric bypass (RYGB).

Metabolism 2018 Dec 23. Epub 2018 Dec 23.

Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, USA 55905. Electronic address:

Glucagon-Like Peptide-1 (GLP-1) is an insulin secretagogue which is elevated after Roux-en-Y Gastric Bypass (RYGB). However, its contribution to glucose metabolism after RYGB remains uncertain.

Aims: We tested the hypothesis that GLP-1 lowers postprandial glucose concentrations and improves β-cell function after RYGB. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.12.005DOI Listing
December 2018
1 Read

The role of metabolism in the pathogenesis of systemic sclerosis.

Metabolism 2018 Dec 23. Epub 2018 Dec 23.

Department of Rheumatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. Electronic address:

Systemic sclerosis (SSc) is an immune-mediated autoimmune disease characterized by fibrosis and vascular abnormalities. The cellular and molecular mechanisms remain unclear, and current therapies are limited. Cell metabolism has been shown to play an essential role in cancer survival and tumour invasion as well as in rheumatic diseases such as systemic lupus erythematosus, rheumatoid arthritis and osteoarthritis. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.12.004DOI Listing
December 2018
1 Read

Diagnosis of obesity and use of obesity biomarkers in science and clinical medicine.

Metabolism 2019 Mar 23;92:61-70. Epub 2018 Dec 23.

Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany; Charité Universitätsmedizin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany; DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany.

The global epidemic of obesity is a major public health problem today. Obesity increases the risk of many chronic diseases, such as type 2 diabetes, coronary heart disease, and certain types of cancer, and is associated with lower life expectancy. The body mass index (BMI), which is currently used to classify obesity, is only an imperfect measure of abnormal or excessive body fat accumulation. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.12.006DOI Listing
March 2019
1 Read

Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-Hydroxysteroid dehydrogenase type 1 transgenic mice.

Metabolism 2018 Dec 18. Epub 2018 Dec 18.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA. Electronic address:

Context: Excessive adipose glucocorticoid action is associated with insulin resistance, but the mechanisms linking adipose glucocorticoid action to insulin resistance are still debated. We hypothesized that insulin resistance from excess glucocorticoid action may be attributed in part to increased ectopic lipid deposition in liver.

Methods: We tested this hypothesis in the adipose specific 11β-Hydroxysteroid dehydrogenase-1 (HSD11B1) transgenic mouse, an established model of adipose glucocorticoid excess. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495183025
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http://dx.doi.org/10.1016/j.metabol.2018.12.003DOI Listing
December 2018
6 Reads

Surgical management of obesity.

Metabolism 2019 Mar 18;92:206-216. Epub 2018 Dec 18.

Department of Surgery, Boston University School of Medicine, Boston, MA, United States of America; Department of Surgery, VA Boston Healthcare System, Boston, MA, United States of America. Electronic address:

Weight loss surgery is the most effective intervention for addressing obesity and related metabolic disorders such as diabetes. We describe common surgical procedures as well as emerging and investigational procedures in terms of their capacity to induce weight reduction and their risk profiles. We then discuss the impact of weight loss surgery on important obesity related disorders including diabetes, cardiovascular disease, and non-alcoholic fatty liver disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495183025
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http://dx.doi.org/10.1016/j.metabol.2018.12.002DOI Listing
March 2019
4 Reads

Childhood obesity: increased risk for cardiometabolic disease and cancer in adulthood.

Metabolism 2019 Mar 5;92:147-152. Epub 2018 Dec 5.

Department of Pediatrics I, Martin-Luther-University Halle-Wittenberg, Halle, Germany.

Prevalence of childhood obesity has worldwide more than doubled since 1980. Underlying factors are complex and are far from completely understood. Strategies to prevent childhood obesity have mainly focused on behavioral intervention; and obesity therapy was mainly based on lifestyle modification to date. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.12.001DOI Listing

Research developments in metabolism 2018.

Metabolism 2019 Feb 29;91:70-79. Epub 2018 Nov 29.

Section of Endocrinology, Beth-Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States of America.

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http://dx.doi.org/10.1016/j.metabol.2018.11.011DOI Listing
February 2019

Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics.

Metabolism 2019 Mar 29;92:82-97. Epub 2018 Nov 29.

Section of Endocrinology, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA.

The obesity epidemic is closely associated with the rising prevalence and severity of nonalcoholic fatty liver disease (NAFLD): obesity has been linked not only with simple steatosis (SS), but also with advanced disease, i.e., nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis and hepatocellular carcinoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495183025
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http://dx.doi.org/10.1016/j.metabol.2018.11.014DOI Listing
March 2019
16 Reads

Central obesity transition increased urinary levels of 8-hydroxydeoxyguanosine in male adults: A 3-year follow up study.

Metabolism 2019 Feb 1;91:53-60. Epub 2018 Dec 1.

Department of Occupational and Environmental Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. Electronic address:

Objective: Association of oxidative DNA damage with gain in anthropometric indices has not been fully elucidated.

Methods: In this study, participants (n = 1151) were derived from the baseline visit of Wuhan residents in the Wuhan-Zhuhai Cohort Study. The participants finished the physical examinations at both baseline and 3-year follow up. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.11.015DOI Listing
February 2019
6 Reads

FoxO1 regulates leptin-induced mood behavior by targeting tyrosine hydroxylase.

Metabolism 2019 Feb 27;91:43-52. Epub 2018 Nov 27.

Department of Oral Biology, BK21 PLUS, Yonsei University College of Dentistry, Seoul 03722, South Korea; Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, South Korea; Department of Wellness & Healthy Aging, Wonju College of Medicine, Yonsei University, Wonju 26426, South Korea. Electronic address:

Purpose: While leptin has been associated with various psycho-physiological functions, the molecular network in leptin-mediated mood regulation remains elusive.

Methods: Anxiolytic behaviors and tyrosine hydroxylase (TH) levels were examined after leptin administration. Functional roles of STAT3 and FoxO1 in regulation of TH expression were investigated using in vivo and in vitro systems. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.11.013DOI Listing
February 2019

Physiology of energy homeostasis: Models, actors, challenges and the glucoadipostatic loop.

Metabolism 2019 Mar 27;92:11-25. Epub 2018 Nov 27.

Institut de Recherche Biomédicale des Armées, Unité de Physiologie des Exercices et Activités en Conditions Extrêmes, Département Environnements Opérationnels, Brétigny-sur-Orge, France.

The aim of this review is to discuss the physiology of energy homeostasis (EH), which is a debated concept. Thus, we will see that the set-point theory is highly challenged and that other models integrating an anticipative component, such as energy allostasis, seem more relevant to experimental reports and life preservation. Moreover, the current obesity epidemic suggests that EH is poorly efficient in the modern human dietary environment. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.11.012DOI Listing
March 2019
17 Reads

Adiponectin homolog novel osmotin protects obesity/diabetes-induced NAFLD by upregulating AdipoRs/PPARα signaling in ob/ob and db/db transgenic mouse models.

Metabolism 2019 Jan 25;90:31-43. Epub 2018 Oct 25.

Division of Applied Life Science (BK 21), College of Natural Sciences, Gyeongsang National University, Jinju 660-701, Republic of Korea. Electronic address:

Background: In metabolic disorders, adiponectin and adiponectin receptors (AdipoR1/R2) signaling has a key role in improving nonalcoholic fatty liver disease (NAFLD) in obesity-associated diabetes.

Objective: To the best of our knowledge, here, we reported for the first time the underlying mechanistic therapeutic efficacy of the novel osmotin, a homolog of mammalian adiponectin, against NAFLD in leptin-deficient ob/ob and db/db mice.

Methods: The ob/ob and db/db mice were treated with osmotin at a dose of 5 μg/g three times a week for two weeks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495183021
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http://dx.doi.org/10.1016/j.metabol.2018.10.004DOI Listing
January 2019
11 Reads
3.894 Impact Factor

Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα.

Metabolism 2019 Feb 20;91:18-29. Epub 2018 Nov 20.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Scientific Research Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Background: Metformin is a first-line drug for treating type 2 diabetes and has gained considerable interest as a potential anticancer agent. Increasing evidence suggests that metformin antagonizes diabetes and tumors through disrupting metabolic homeostasis and altering energy state. However, whether AMP activated protein kinase (AMPK) contributes to such effects of metformin remains controversial. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.11.010DOI Listing
February 2019
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3.894 Impact Factor

Maternal lipid profile differs by gestational diabetes physiologic subtype.

Metabolism 2019 Feb 20;91:39-42. Epub 2018 Nov 20.

Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA; Centre de Recherche du Centre hospitalier universitaire de Sherbrooke (CHUS), Québec, Canada; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:

Aim: To characterize lipid profiles in women with different gestational diabetes mellitus (GDM) physiologic subtypes.

Methods: We measured seven lipid markers (total cholesterol, LDL, HDL, triglycerides, non-esterified fatty acids (NEFA), ApoA, ApoB) in fasting plasma collected in a prospective cohort of 805 pregnant women during second trimester. We estimated insulin sensitivity and secretion using oral glucose tolerance test-based validated indices. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.11.008DOI Listing
February 2019
4 Reads

Metabolically healthy versus metabolically unhealthy obesity.

Metabolism 2019 Mar 17;92:51-60. Epub 2018 Nov 17.

Department of Clinical and Molecular Medicine, "La Sapienza" University, Rome, Italy. Electronic address:

Obesity-related disease complications reduce life quality and expectancy and increase health-care costs. Some studies have suggested that obesity not always entails metabolic abnormalities and increased risk of cardiometabolic complications. Because of the lack of universally accepted criteria to identify metabolically healthy obesity (MHO), its prevalence varies widely among studies. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.11.009DOI Listing
March 2019
2 Reads

Could the endocrine disruptor bisphenol-A be implicated in the pathogenesis of oral and oropharyngeal cancer? Metabolic considerations and future directions.

Metabolism 2019 Feb 17;91:61-69. Epub 2018 Nov 17.

Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias street, 115 27 Athens, Greece. Electronic address:

Bisphenol-A (BPA), a prototype endocrine disrupting molecule, has been associated with many disease entities such as diabetes mellitus, obesity, polycystic ovarian disease, cardiovascular disease, reproductive and neurodevelopmental disorders. BPA has also been associated mainly with not only hormone sensitive cancers such as breast, prostate, endometrial, ovarian, testicular and thyroid cancers but also non-hormonal sensitive cancers such as cervical and lung cancers, osteosarcoma and meningioma. Recent research has investigated the sources of contamination which are responsible for higher BPA concentrations in the oral cavity and oropharyngeal space, representing the first site of BPA exposure after ingestion. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.11.007DOI Listing
February 2019
3 Reads

High plasma FGF21 levels predicts major cardiovascular events in patients treated with atorvastatin (from the Treating to New Targets [TNT] Study).

Metabolism 2018 Nov 16. Epub 2018 Nov 16.

Lipid Research Group, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.

Background: Higher plasma fibroblast growth factor 21 (FGF21) levels predict incident cardiovascular events in type 2 diabetes patients. However, whether FGF21 levels predict cardiovascular events in statin-treated patients in the general population is unknown. We investigated whether FGF21 levels predict major cardiovascular event (MCVE) in the Treating to New Targets (TNT) trial participants. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.11.006DOI Listing
November 2018
9 Reads

Glucagon-like peptide 1 (GLP-1) drives postprandial hyperinsulinemic hypoglycemia in pregnant women with a history of Roux-en-Y gastric bypass operation.

Metabolism 2019 Feb 15;91:10-17. Epub 2018 Nov 15.

Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Unit of Gender Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. Electronic address:

Background: The influential role of incretin hormones on glucose metabolism in patients with a history of Roux-en-Y gastric bypass (RYGB) has been investigated thoroughly, but there has been little examination of the effect of incretins and ectopic lipids on altered glucose profiles, especially severe hypoglycemia in pregnant women with RYGB.

Methods: In this prospective clinical study, an oral glucose tolerance test (OGTT), an intravenous glucose tolerance test (IVGTT), and continuous glucose monitoring (CGM) were conducted in 25 women with RYGB during pregnancy, 19 of normal weight (NW) and 19 with obesity (OB) between the 24th and the 28th weeks of pregnancy, and 3 to 6 months post-partum. Post-partum, the ectopic lipid content in the liver, heart, and skeletal muscle was analyzed using H-magnetic resonance spectroscopy (H-MRS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495183022
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http://dx.doi.org/10.1016/j.metabol.2018.10.006DOI Listing
February 2019
11 Reads

Obesity and dyslipidemia.

Metabolism 2019 Mar 14;92:71-81. Epub 2018 Nov 14.

Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.

Obesity, a pandemic of the modern world, is intimately associated with dyslipidemia, which is mainly driven by the effects of insulin resistance and pro-inflammatory adipokines. However, recent evidence suggests that obesity-induced dyslipidemia is not a unique pathophysiological entity, but rather has distinct characteristics depending on many individual factors. In line with that, in a subgroup of metabolically healthy obese (MHO) individuals, dyslipidemia is less prominent or even absent. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.11.005DOI Listing
March 2019
9 Reads

Obesity and cancer risk: Emerging biological mechanisms and perspectives.

Metabolism 2019 Mar 13;92:121-135. Epub 2018 Nov 13.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece. Electronic address:

Continuously rising trends in obesity-related malignancies render this disease spectrum a public health priority. Worldwide, the burden of cancer attributable to obesity, expressed as population attributable fraction, is 11.9% in men and 13. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495183023
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http://dx.doi.org/10.1016/j.metabol.2018.11.001DOI Listing
March 2019
27 Reads

Characteristics of obesity in polycystic ovary syndrome: Etiology, treatment, and genetics.

Metabolism 2019 Mar 13;92:108-120. Epub 2018 Nov 13.

The Cholesterol, Metabolism, and Thrombosis Research Center, 3906 Middleton Avenue, Cincinnati, OH 45220, United States of America.

Polycystic ovary syndrome (PCOS) has multiple etiologies including ovarian and adrenal hyperandrogenism, neuro-endocrine and hypothalamic-pituitary dysfunction, and disorders of peripheral insulin resistance. Obesity is neither necessary nor sufficient for the PCOS phenotype, and the association of PCOS with obesity is not universal, with national, cultural, and ethnic differences. Obesity, particularly visceral adiposity which is common in obese and non-obese women with PCOS, amplifies and worsens all metabolic and reproductive outcomes in PCOS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495183023
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http://dx.doi.org/10.1016/j.metabol.2018.11.002DOI Listing
March 2019
7 Reads

Conditioned media from contracting skeletal muscle potentiates insulin secretion and enhances mitochondrial energy metabolism of pancreatic beta-cells.

Metabolism 2019 Feb 13;91:1-9. Epub 2018 Nov 13.

School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, UK; Institute for Metabolism and Systems Research (IMSR), University of Birmingham, UK.

Aims/hypothesis: In this study, we aimed to examine real-time effects of molecules released by contracting skeletal muscle on the insulin secretory function of β-cells using a novel perifusion platform. We hypothesised that media conditioned by contracting skeletal muscle will influence insulin secretion and mitochondrial energy metabolism in β-cells under normal and type-2 diabetic conditions.

Methods: INS-1 832/3 pseudoislets were perifused with media from C2C12 myotubes treated with or without electrical pulse stimulation (EPS; 40 V, 1. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.11.004DOI Listing
February 2019
8 Reads

Leptin trajectories from birth to mid-childhood and cardio-metabolic health in early adolescence.

Metabolism 2019 Feb 7;91:30-38. Epub 2018 Nov 7.

Division of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address:

Objectives: Leptin is a hormone produced by adipose tissue that promotes satiety, and some evidence suggests that greater early life leptin exposure prevents excessive adiposity gain in later life. However, few studies have analyzed dynamic changes in leptin throughout childhood in relation to later cardio-metabolic health. Our study aims to identify distinct leptin trajectories in childhood, and to examine their associations with cardio-metabolic outcomes in adolescence. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366620PMC
February 2019
8 Reads

Burden of cancer attributable to obesity, type 2 diabetes and associated risk factors.

Metabolism 2019 Mar 6;92:136-146. Epub 2018 Nov 6.

Hospital Virgen del Camino, carretera de Chipiona km 0.64, 11540 Sanlúcar de Barrameda, Cádiz, Spain. Electronic address:

Overweight and obesity constitute a global pandemic with devastating consequences that affect >2 billion people. Obesity plays a central role in morbidity and mortality of diseases of multiple organs and systems, and it is a major contributor to the growing incidence of cancer. There is now sufficient level of evidence for the association between overweight and 11 types of cancer, among which are two of the most common cancers worldwide, those of the colorectum and postmenopausal breast. Read More

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http://dx.doi.org/10.1016/j.metabol.2018.10.013DOI Listing
March 2019
23 Reads

Obesity and cardiovascular disease: revisiting an old relationship.

Metabolism 2019 Mar 3;92:98-107. Epub 2018 Nov 3.

First Department of Propaedeutic Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece. Electronic address:

A wealth of clinical and epidemiological evidence has linked obesity to a broad spectrum of cardiovascular diseases (CVD) including coronary heart disease, heart failure, hypertension, stroke, atrial fibrillation and sudden cardiac death. Obesity can increase CVD morbidity and mortality directly and indirectly. Direct effects are mediated by obesity-induced structural and functional adaptations of the cardiovascular system to accommodate excess body weight, as well as by adipokine effects on inflammation and vascular homeostasis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495183022
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http://dx.doi.org/10.1016/j.metabol.2018.10.011DOI Listing
March 2019
3 Reads

Genetics and epigenetics in obesity.

Metabolism 2019 Mar 3;92:37-50. Epub 2018 Nov 3.

Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig 04103, Germany; University of Oslo, Institute of Clinical Medicine, Oslo 0316, Norway; Akershus University Hospital, Department of Clinical Molecular Biology, Medical Division, Lørenskog 1478, Norway. Electronic address:

Obesity is among the most threatening health burdens worldwide and its prevalence has markedly increased over the last decades. Obesity maybe considered a heritable trait. Identifications of rare cases of monogenic obesity unveiled that hypothalamic circuits and the brain-adipose axis play an important role in the regulation of energy homeostasis, appetite, hunger and satiety. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495183022
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http://dx.doi.org/10.1016/j.metabol.2018.10.007DOI Listing
March 2019
13 Reads