7,679,331 results match your criteria Metabolism: clinical and experimental[Journal]

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Effect of glycolysis inhibition by miR-448 on glioma radiosensitivity.

J Neurosurg 2019 Apr 19:1-9. Epub 2019 Apr 19.

4Department of Neurosurgery, The Affiliated Hospital of Xiangnan University, Chenzhou, Hunan, People's Republic of China.

OBJECTIVEAlthough glucose metabolism reengineering is a typical feature of various tumors, including glioma, key regulators of glycolytic reprogramming are still poorly understood. The authors sought to investigate whether glycolysis inhibition by microRNA (miR)-448 increases radiosensitivity in glioma cells.METHODSThe authors used glioma tissue samples from glioma patients, cells from glioblastoma (GBM) cell lines and normal human astrocyte cells, and subcutaneous tumor-bearing U87 cells in mice to examine the effects of signaling regulation by miR-448 in the response of glioma tissues and cells to radiation treatment. Read More

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https://thejns.org/view/journals/j-neurosurg/aop/article-10.
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http://dx.doi.org/10.3171/2018.12.JNS181798DOI Listing
April 2019
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Effect of plant-based diets with varying ratios of ω6 to ω3 fatty acids on growth performance, tissue composition, fatty acid biosynthesis and lipid-related gene expression in Atlantic salmon (Salmo salar).

Comp Biochem Physiol Part D Genomics Proteomics 2019 Mar 16;30:290-304. Epub 2019 Mar 16.

Department of Ocean Sciences, Memorial University of Newfoundland, St. John's A1C 5S7, NL. Canada. Electronic address:

Little is known about how variation in omega-6 to omega-3 (ω6:ω3) fatty acid (FA) ratios affects lipid metabolism and eicosanoid synthesis in salmon, and the potential underlying molecular mechanisms. The current study examined the impact of five plant-based diets (12-week exposure) with varying ω6:ω3 (0.3-2. Read More

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http://dx.doi.org/10.1016/j.cbd.2019.03.004DOI Listing

Comparative study of Cu uptake and early transcriptome responses in the green microalga Chlamydomonas reinhardtii and the macrophyte Elodea nuttallii.

Environ Pollut 2019 Apr 10;250:331-337. Epub 2019 Apr 10.

Department F.-A. Forel for Environmental and Aquatic Sciences, Earth and Environmental Sciences, Faculty of Sciences, University of Geneva, 66, Boulevard Carl-Vogt, CH-1211, Geneva 4, Switzerland. Electronic address:

Microalgae are widely used as representative primary producers in ecotoxicology, while macrophytes are much less studied. Here we compared the bioavailability and cellular toxicity pathways of 2 h-exposure to 10 mol L Cu in the macrophyte Elodea nuttallii and the green microalga Chlamydomonas reinhardtii. Uptake rate was similar but faster in the algae than in the macrophyte, while RNA-Sequencing revealed a similar number of regulated genes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183557
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http://dx.doi.org/10.1016/j.envpol.2019.04.032DOI Listing
April 2019
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Moderate hearing loss is related with social frailty in a community-dwelling older adults: The Korean Frailty and Aging Cohort Study (KFACS).

Arch Gerontol Geriatr 2019 Apr 12;83:126-130. Epub 2019 Apr 12.

Department of Family Medicine, Kyung Hee University Medical Center, kyungheedaero 23, dongdaemun-gu, 02447, Seoul, Republic of Korea; Elderly Frailty Research Center, Department of Family Medicine, Kyung Hee University College of Medicine, kyungheedaero 23, dongdaemun-gu, 02447, Seoul, Republic of Korea. Electronic address:

Objectives: To determine whether hearing loss is associated with social frailty in older adults.

Methods: Cross-sectional analysis of cohort study data. Hearing was measured using of Pure-tone audiometry. Read More

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http://dx.doi.org/10.1016/j.archger.2019.04.004DOI Listing

Association between sarcopenia and diabetes in community dwelling elderly in the Amazon region - Viver Mais Project.

Arch Gerontol Geriatr 2019 Mar 27;83:121-125. Epub 2019 Mar 27.

State University Of Pará, Brazil; Hospital Cynthia Charone, Brazil.

Background: Studies indicate the intrinsic relationship between sarcopenia and diabetes mellitus (DM) pathophysiological mechanisms. Changes in insulin and muscular metabolism are features of diabetic patients and can interact as sarcopenic accelerators. Conversely, sarcopenic patients feature lower glucose tolerance and higher serum insulin levels, predisposing them to DM. Read More

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http://dx.doi.org/10.1016/j.archger.2019.03.020DOI Listing

PCB52 induces hepatotoxicity in male offspring through aggravating loss of clearance capacity and activating the apoptosis: Sex-biased effects on rats.

Chemosphere 2019 Apr 12;227:389-400. Epub 2019 Apr 12.

Department of Forensic Pathology, School of Forensic Medicine, Southern Medical University, No. 1838 North Guangzhou Road, 510515, Guangzhou, China. Electronic address:

Polychlorinated biphenyls (PCBs), a kind of persistent organic pollutant, can induce hepatotoxicity in mammals. However, PCB-induced hepatotoxicity in offspring and the underlying mechanisms have been rarely studied. In the present study, Wistar rats were administered with corn oil or PCB52 (1 mg/kg body weight/day, by gavage) from gestational day 7 to postnatal day 21. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193072
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http://dx.doi.org/10.1016/j.chemosphere.2019.04.077DOI Listing
April 2019
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Associations between urinary organophosphate ester metabolites and measures of adiposity among U.S. children and adults: NHANES 2013-2014.

Environ Int 2019 Apr 16;127:754-763. Epub 2019 Apr 16.

Maryland Institute of Applied Environmental Health, School of Public Health, University of Maryland, College Park, MD, USA. Electronic address:

Background: Organophosphate esters (OPEs) are synthetic chemicals found in many consumer products, including furniture, electronics, processed foods, and building materials. Emerging in vitro and in vivo studies suggest that OPEs are metabolism disrupting compounds; however, epidemiologic studies investigating their associations with adiposity markers are sparse.

Objective: We examined cross-sectional associations between OPE biomarkers and adiposity measures among U. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01604120183283
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http://dx.doi.org/10.1016/j.envint.2019.03.055DOI Listing
April 2019
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Ecotoxicological effects of lanthanum in Mytilus galloprovincialis: Biochemical and histopathological impacts.

Aquat Toxicol 2019 Mar 25;211:181-192. Epub 2019 Mar 25.

Departamento de Biologia & CESAM, Universidade de Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

Inappropriate processing and disposal of electronic waste contributes to the contamination of aquatic systems by various types of pollutants such as the rare-earth elements (REE) in which lanthanum (La) is included. Knowledge on the toxicity of these elements in marine organisms is still scarce when compared to other metals such as mercury (Hg) and arsenic (As). Therefore, this study aims to assess the toxicity of La on the mussel Mytilus galloprovincialis, considered a good bioindicator of aquatic pollution, through the analysis of metabolic, oxidative stress, neurotoxicity and histopathological markers. Read More

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http://dx.doi.org/10.1016/j.aquatox.2019.03.017DOI Listing

The skeletal renin-angiotensin system: A potential therapeutic target for the treatment of osteoarticular diseases.

Int Immunopharmacol 2019 Apr 16;72:258-263. Epub 2019 Apr 16.

Translational Medicine Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, China.

The classical renin-angiotensin system (RAS) is known to be a key regulator of blood pressure as well as fluid and electrolyte homeostasis. Additionally, it is now evident that components of the RAS are produced and act locally in many tissues, including liver, kidney, heart, lung, eye, bone, reproductive organ, adipose, and adrenal tissue, and these components are collectively known as tissue RAS. Recently, several studies have shown that local bone RAS is directly involved in bone metabolism, and activation of skeletal RAS plays an important role in bone diseases, such as osteoporosis, arthritis, and deterioration as well as in fracture healing. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.023DOI Listing
April 2019
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A proteomic and biochemical investigation on the effects of sulfadiazine in Arabidopsis thaliana.

Ecotoxicol Environ Saf 2019 Apr 16;178:146-158. Epub 2019 Apr 16.

DAFNAE, University of Padova, Viale Università 16, 30520 Legnaro, PD, Italy.

Animal manure or bio-solids used as fertilizers are the main routes of antibiotic exposure in the agricultural land, which can have immense detrimental effects on plants. Sulfadiazine (SDZ), belonging to the class of sulfonamides, is one of the most detected antibiotics in the agricultural soil. In this study, the effect of SDZ on the growth, changes in antioxidant metabolite content and enzyme activities related to oxidative stress were analysed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513193042
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http://dx.doi.org/10.1016/j.ecoenv.2019.04.008DOI Listing
April 2019
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Oxidative stress-induced senescence markedly increases disc cell bioenergetics.

Mech Ageing Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Orthopedic Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, 15213, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Electronic address:

Cellular senescence is a phenotype characterized by irreversible growth arrest, chronic elevated secretion of proinflammatory cytokines and matrix proteases, a phenomenon known as senescence associated secretory phenotype (SASP). Biomarkers of cellular senescence have been shown to increase with age and degeneration of human disc tissue. Senescent disc cells in culture recapitulate features associated with age-related disc degeneration, including increased secretion of proinflammatory cytokines, matrix proteases, and fragmentation of matrix proteins. Read More

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http://dx.doi.org/10.1016/j.mad.2019.04.006DOI Listing

Role of AMPK and its molecular intermediates in subjugating cancer survival mechanism.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, Hebei, China.

The gradual energy dissipation of all organisms allows adapting to energy demands. Pathological situations of uncured diseases such as cancer, diabetes, and other obesity-related diseases are caused by an abrupt energy imbalance. As an energy sensor, AMP-activated kinase (AMPK) can regulate the cellular energy status. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.039DOI Listing

Abnormality of hepatic triglyceride metabolism in Apc mice with colon cancer cachexia.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, No.5333 Xi'an Road, Lvyuan District, Changchun 130062, Jilin Province, China. Electronic address:

Aims: Colorectal cancer syndrome has been one of the greatest concerns in the world. Although several epidemiological studies have shown that hepatic low lipoprotein lipase (LPL) mRNA expression may be associated with dyslipidemia and tumor progression, it is still not known whether the liver plays an essential role in hyperlipidemia of Apc mice.

Main Methods: We measured the expression of metabolic enzymes that involved fatty acid uptake, de novo lipogenesis (DNL), β-oxidation and investigated hepatic triglyceride production in the liver of wild-type and Apc mice. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.041DOI Listing

Maternal hyperuricemia superimposed on maternal hypertension aggravates the risk of small-for-gestational-age fetus.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong 250021, China. Electronic address:

Aims: Small-for-gestational-age (SGA) fetus is an important public health issue because of its high mortality and long-term effects on health. Maternal hyperuricemia is associated with diverse adverse pregnant outcomes and neonatal disturbance. We aimed to evaluate whether maternal hyper-uric acid (HUA) is associated with the risk of SGA fetus and to explore whether it can modify the association between maternal hyper-blood pressure (HBP) and SGA fetus. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.033DOI Listing

Insulin treatment protects the brain against neuroinflammation by reducing cerebral cytokines and modulating mitochondrial function.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-00 Criciúma, SC, Brazil. Electronic address:

In the central nervous system, glial cells protect the brain against neuronal stress by inducing inflammatory responses; namely, intracellular signaling and cytokine production. However, chronic inflammation is often associated with degenerative diseases that can damage hormone signaling and mitochondrial function. Lipopolysaccharide (LPS) induces neuroinflammation by stimulating the production of interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α); moreover, it generates oxidative stress and impairs cognitive functions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183094
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http://dx.doi.org/10.1016/j.brainresbull.2019.04.011DOI Listing
April 2019
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Comparative transcriptome analyses reveal changes of gene expression in fresh and cryopreserved yellow catfish (Pelteobagrus fulvidraco) sperm and the effects of Cryoprotectant MeSO.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:

This study, for the first time in fish, compared the transcriptome of fresh and frozen-thawed sperm, and would help to better understand the effect of cryopreservation on fish sperm and then better preserve the aquatic germplasm resources. Here, we employed high-throughput sequencing technology to obtain the transcriptome of yellow catfish from fresh sperm, cryopreserved sperm with and without cryoprotectant. When cryoprotectant (MeSO) was excluded, down-regulated genes were significantly enriched into calcium ion binding, cytoskeletal protein binding, microfilament motor activity and carnitine O-acyltransferase activity, which affected Ca regulation, cellular morphology, motility and metabolism. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.050DOI Listing

The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea.

Alcohol 2019 Apr 16. Epub 2019 Apr 16.

Division of Endocrine and Metabolic Disease, Center for Biomedical Sciences, Korea National Institute of Health, Cheongju, Chungbuk, 28159, South Korea.

Background: Excessive alcohol consumption is a major public health problem in East Asian countries. Alcohol use leads to a cascade of problems including increased chances of risky behavior and wide range of negative health consequences from alcoholic liver disease to upper gastric and liver cancer. These alcohol effects are known to be influenced by ethnic variability and genetics. Read More

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http://dx.doi.org/10.1016/j.alcohol.2019.03.004DOI Listing

Metabolic and physiological perturbations of Escherichia coli W3100 by bacterial small RNA RyhB.

Biochimie 2019 Apr 16. Epub 2019 Apr 16.

Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, 230027, People's Republic of China. Electronic address:

RyhB is a key regulator of iron level in Escherichia coli (E. coli), which assists in conserving iron for life-sustaining cellular functions when cytoplasmic levels of the ferrous form of iron is limited. RyhB affects glucose metabolism. Read More

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http://dx.doi.org/10.1016/j.biochi.2019.04.016DOI Listing

Effect of estradiol on hepatopancreatic lipid metabolism in the swimming crab, Portunus trituberculatus.

Gen Comp Endocrinol 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai 201306, China; Centre for Research on Environmental Ecology and Fish Nutrition of Ministry of Agriculture and Rural Affairs, Shanghai Ocean University, Shanghai, 201306, China; National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, China. Electronic address:

Estradiol is an important sex steroid hormone that involved in regulation of animal lipid metabolism. However, the effect of estradiol on lipid metabolism in swimming crab (Portunus trituberculatus) is unclear. The present study investigated the effect of four concentrations of exogenous estradiol (0, 0. Read More

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http://dx.doi.org/10.1016/j.ygcen.2019.04.019DOI Listing

Inhibitory action of thymol on fecal microbial activity in Tamandua tetradactyla and its effect on glucocorticoid metabolite measurement.

Gen Comp Endocrinol 2019 Apr 16. Epub 2019 Apr 16.

Instituto de Ciencia y Tecnología de los Alimentos and Facultad de Ciencias Exactas, Físicas y Naturales (FCEFyN), Universidad Nacional de Córdoba (UNC), Argentina.

Faecal glucocorticoid measurement is a potentially important tool for improving wildlife conservation, but its use is still limited by methodological issues including the need to avoid modifications of steroids by faecal microorganisms during storage. The freezing of faeces is recommended as a means of avoiding such alterations, but this is costly under non-controlled environmental conditions. The present study was designed to determine whether the application of thymol reduced the proliferation of microorganisms in the faeces of Tamandua tetradactyla and whether it influenced faecal glucocorticoid metabolite (FGM) measurements. Read More

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http://dx.doi.org/10.1016/j.ygcen.2019.04.015DOI Listing

Human adipocytes and CD34 cells from the stromal vascular fraction of the same adipose tissue differ in their energy metabolic enzyme configuration.

Exp Cell Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Cell Biology, University Medicine Rostock, Schillingallee 69, 18057 Rostock, Germany. Electronic address:

Adipose tissue plays a role in energy storage and metabolic balance and is composed of different cell types. The metabolic activity of the tissue itself has been a matter of research for a long time, but comparative data about the energy metabolism of different cell types of human subcutaneous adipose tissue are sparse. Therefore, we compared the activity of major energy metabolic pathways of adipocytes and CD34 cells from the stromal vascular fraction (SVF) separated from the same tissue. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144827193019
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http://dx.doi.org/10.1016/j.yexcr.2019.04.018DOI Listing
April 2019
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Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.

Cell 2019 Apr;177(3):587-596.e9

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Severe obesity is a rapidly growing global health threat. Although often attributed to unhealthy lifestyle choices or environmental factors, obesity is known to be heritable and highly polygenic; the majority of inherited susceptibility is related to the cumulative effect of many common DNA variants. Here we derive and validate a new polygenic predictor comprised of 2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193029
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http://dx.doi.org/10.1016/j.cell.2019.03.028DOI Listing
April 2019
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Chemerin and Dermcidin in Human Milk and Their Alteration in Gestational Diabetes.

J Hum Lact 2019 Apr 19:890334419837523. Epub 2019 Apr 19.

5 Department of Medical Biochemistry and Clinical Biochemistry, Firat Hormones Research Group, Medical School, Firat University, Elazig, Turkey.

Background: Chemerin and dermcidin, which have antimicrobial properties, are molecules that are also related to insulin resistance and inflammation.

Research Aims: The aims were to determine the amounts of chemerin and dermcidin in the milk and blood of mothers with gestational diabetes, and to compare the amounts of chemerin and dermcidin in the milk and blood of mothers with and without diabetes.

Methods: This was a two-group nonrandomized longitudinal study with a convenience sampling of mothers without gestational diabetes ( n = 27) and mothers with gestational diabetes ( n = 26). Read More

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http://dx.doi.org/10.1177/0890334419837523DOI Listing

Niche-specific metabolic adaptation in biotrophic and necrotrophic oomycetes is manifested in differential use of nutrients, variation in gene content, and enzyme evolution.

PLoS Pathog 2019 Apr 19;15(4):e1007729. Epub 2019 Apr 19.

Department of Microbiology and Plant Pathology, University of California, Riverside United States of America.

The use of host nutrients to support pathogen growth is central to disease. We addressed the relationship between metabolism and trophic behavior by comparing metabolic gene expression during potato tuber colonization by two oomycetes, the hemibiotroph Phytophthora infestans and the necrotroph Pythium ultimum. Genes for several pathways including amino acid, nucleotide, and cofactor biosynthesis were expressed more by Ph. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007729DOI Listing

Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma.

PLoS One 2019 19;14(4):e0215770. Epub 2019 Apr 19.

Departments of Medicine and Biochemistry & the Stony Brook Cancer Center at Stony Brook University, Stony Brook, New York, United States of America.

The purpose of this study was to determine the profile of bioactive sphingolipids in xenograft mouse tissues of head and neck squamous cell carcinoma. We utilized UHPLC-MS/MS to determine the profile of full set of ceramides, sphingosine, and sphingosine 1-phosphate in this xenograft mouse model. The tissues isolated and investigated were from brain, lung, heart, liver, spleen, kidney, bladder, tumors and blood. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215770PLOS

Identification of cotton MOTHER OF FT AND TFL1 homologs, GhMFT1 and GhMFT2, involved in seed germination.

PLoS One 2019 19;14(4):e0215771. Epub 2019 Apr 19.

Special Plant Genomics Laboratory, College of Life Sciences, Shihezi University, Shihezi, Xinjiang, China.

Plant phosphatidylethanolamine-binding protein (PEBP) is comprised of three clades: FLOWERING LOCUS T (FT), TERMINAL FLOWER1 (TFL1) and MOTHER OF FT AND TFL1 (MFT). FT/TFL1-like clades regulate identities of the determinate and indeterminate meristems, and ultimately affect flowering time and plant architecture. MFT is generally considered to be the ancestor of FT/TFL1, but its function is not well understood. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215771PLOS

Epigenetic regulator G9a provides glucose as a sweet key to stress resistance.

PLoS Biol 2019 Apr 19;17(4):e3000236. Epub 2019 Apr 19.

Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, The University of British Columbia, Vancouver, British Columbia, Canada.

The ability to adapt to acute and chronic stress is important for organisms to thrive in evolutionary niches and for cells to survive in adverse conditions. The regulatory networks that control stress responses are evolutionarily conserved, and many factors that selectively activate stress responses have been identified. Less well understood are mechanisms that guard against unnecessary induction of cytoprotective factors and that connect stress responses with cellular metabolism to control energy expenditure during stress. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000236DOI Listing

Investigating the deregulation of metabolic tasks via Minimum Network Enrichment Analysis (MiNEA) as applied to nonalcoholic fatty liver disease using mouse and human omics data.

PLoS Comput Biol 2019 Apr 19;15(4):e1006760. Epub 2019 Apr 19.

Laboratory of Computational Systems Biotechnology, EPFL, Lausanne, Switzerland.

Nonalcoholic fatty liver disease (NAFLD) is associated with metabolic syndromes spanning a wide spectrum of diseases, from simple steatosis to the more complex nonalcoholic steatohepatitis. To identify the deregulation that occurs in metabolic processes at the molecular level that give rise to these various NAFLD phenotypes, algorithms such as pathway enrichment analysis (PEA) can be used. These analyses require the use of predefined pathway maps, which are composed of reactions describing metabolic processes/subsystems. Read More

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http://dx.plos.org/10.1371/journal.pcbi.1006760
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http://dx.doi.org/10.1371/journal.pcbi.1006760DOI Listing
April 2019
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Effects of Sleep Deprivation (SD) on Rats via ERK1/2 Signaling Pathway.

Med Sci Monit 2019 Apr 19;25:2886-2895. Epub 2019 Apr 19.

Department of Neurology, Yantai Yuhuangding Hospital, Yantai, Shandong, China (mainland).

BACKGROUND Sleep deprivation (SD) is common in humans, and sleep loss has a significant influence on health and produces related diseases. Orexin-A has been demonstrated to play a role in physiological processes, including feeding, sleep/wake cycle, and energy metabolism. The aim of this study was to investigate the effect of SD on rats and to define the underlying mechanism. Read More

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http://dx.doi.org/10.12659/MSM.913839DOI Listing

Expression of Gstt1 in Type 2 Diabetic Retinopathy Patients.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):47-50

Department of Zoology, Lahore College for Women University, Lahore, Pakistan.

Type 2 diabetes mellitus (T2DM) is the most common metabolic and multifactorial disease in which both genetic and environmental factors are involved. In diabetes, the defects in the cellular metabolism result in higher levels of free radicals. These radicals react with other vital cellular molecules, which are responsible in diabetes side effects and known as diabetic retinopathy (DR), a disease of the retina that results in impairment or loss of vision. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2019025074DOI Listing
January 2019

Evaluating crisaborole as a treatment option for atopic dermatitis.

Expert Opin Pharmacother 2019 Apr 19:1-7. Epub 2019 Apr 19.

d Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.

Introduction: Atopic dermatitis (AD) is a chronic and recurrent disease presenting with eczematous lesions and pruritus. It impacts patient and family quality of life, increases morbidity, and accounts for large health-care expenditures. Although nonpharmacologic, topical, and systemic treatments exist, management of AD remains challenging due to limited treatment options. Read More

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http://dx.doi.org/10.1080/14656566.2019.1604688DOI Listing

Myonectin deletion promotes adipose fat storage and reduces liver steatosis.

FASEB J 2019 Apr 19:fj201900520R. Epub 2019 Apr 19.

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

We recently described myonectin (also known as erythroferrone) as a novel skeletal muscle-derived myokine with metabolic functions. Here, we use a genetic mouse model to determine myonectin's requirement for metabolic homeostasis. Female myonectin-deficient mice had larger gonadal fat pads and developed mild insulin resistance when fed a high-fat diet (HFD) and had reduced food intake during refeeding after an unfed period but were otherwise indistinguishable from wild-type littermates. Read More

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http://dx.doi.org/10.1096/fj.201900520RDOI Listing

Mammary adipose stromal cells derived from obese women reduce sensitivity to the aromatase inhibitor anastrazole in an organotypic breast model.

FASEB J 2019 Apr 19:fj201802347RRR. Epub 2019 Apr 19.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Aromatase inhibitors are the preferred treatment for certain women with estrogen receptor (ER)-positive breast cancer, but evidence suggests that women with obesity experience aromatase inhibitor resistance at higher rates. To compare how stromal cells derived from women who are lean or obese influence response to the aromatase inhibitor (anastrazole), we incorporated patient-derived stroma in a previously characterized MCF7-derived duct model. Coculture with adipose stromal cells enabled the metabolism of testosterone (T) to E, which induced estrogen response element activity, epithelial proliferation, and hyperplasia in MCF7 cells. Read More

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http://dx.doi.org/10.1096/fj.201802347RRRDOI Listing

Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial.

Obesity (Silver Spring) 2019 Apr 19. Epub 2019 Apr 19.

Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

Objective: This study aimed to assess the effects of 9-hour time-restricted feeding (TRF), early (TRFe) or delayed (TRFd), on glucose tolerance in men at risk for type 2 diabetes.

Methods: Fifteen men (age 55 ± 3 years, BMI 33.9 ± 0. Read More

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http://dx.doi.org/10.1002/oby.22449DOI Listing

Normothermic Machine Perfusion in Liver Transplantation: Avoiding Recooling Before Engrafting Is Feasible and Promising.

Liver Transpl 2019 Apr 19. Epub 2019 Apr 19.

Abdominal Surgery and Organ Transplantation Unit, Department for the Treatment and Study of Abdominal Diseases and Abdominal Transplantation, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Palermo, Italy.

It is well known that ischemia and the reperfusion process are distinct nonimmunological events that negatively impact graft outcome and induce delayed graft function, which are associated with high rates of organ failure, retransplantation, and death. Cooling the organ slows metabolism but does not prevent its progressive dysfunction and destruction of cellular integrity. On the other hand, in the reperfusion phase, the reactive oxygen metabolites cause leukocyte accumulation and therefore increased microvascular permeability and cellular injury. Read More

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http://dx.doi.org/10.1002/lt.25473DOI Listing

Nitrogen utilization and metabolism in maize (Zea mays L.) plants under different rates of biochar addition and nitrogen input conditions.

Plant Biol (Stuttg) 2019 Apr 19. Epub 2019 Apr 19.

Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, Liaoning Province, China.

Biochar (BC) application could improve plant nitrogen (N) utilization and potentially reduce N fertilizer requirements. However, the fate of N in crop-soil systems and the metabolic responses of crops under the condition of BC coapplied with reduced N are not well understood. The urea- N isotope and pot experiments with three BC rates (0%, 5% and 15%; w/w) combined with three N fertilizer levels (100%-N, 85%-N and 55%-N) were conducted for maize. Read More

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http://dx.doi.org/10.1111/plb.12997DOI Listing

Closed-loop insulin delivery in end-of-life care: a case report.

Diabet Med 2019 Apr 19. Epub 2019 Apr 19.

Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

Background: Glucose management for people with diabetes approaching the end of life can be very challenging. The aim is to balance a minimally invasive approach with avoidance of symptomatic hypo- and hyperglycaemia.

Case Report: We present a case of a hospitalized individual whose glucose was managed with closed-loop insulin delivery within a randomized controlled trial setting during a period of terminal illness. Read More

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http://dx.doi.org/10.1111/dme.13974DOI Listing

Population modeling highlights drug disposition differences between tenofovir alafenamide and tenofovir disoproxil fumarate in the blood and semen.

Clin Pharmacol Ther 2019 Apr 19. Epub 2019 Apr 19.

Unc Eshelman School Of Pharmacy, Division Of Pharmacotherapy And Experimental Therapeutics, University Of North Carolina At Chapel Hill, Chapel Hill, NC.

Understanding antiretroviral disposition in the male genital tract, a distinct viral compartment, can provide insight for HIV eradication. Population pharmacokinetic modeling was conducted to investigate the disposition of tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF), and emtricitabine and their metabolites in blood and semen. Blood plasma and seminal plasma (SP) concentrations of tenofovir and emtricitabine, and tenofovir-diphosphate and emtricitabine-triphosphate concentrations in the peripheral blood mononuclear cells (PBMC) and seminal mononuclear cells, were measured. Read More

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http://dx.doi.org/10.1002/cpt.1464DOI Listing

Use of 4β-hydroxycholesterol plasma concentrations as an endogenous biomarker of CYP3A activity: Clinical validation in individuals with type 2 diabetes.

Clin Pharmacol Ther 2019 Apr 19. Epub 2019 Apr 19.

Faculty of Pharmacy, Université de Montréal, Montreal, QC, Canada.

The relevance of endogenous 4β-hydroxycholesterol (4β-OHC) plasma concentrations or of the 4β-OHC/total cholesterol concentration ratio (4β-OHC ratio) as surrogate markers of CYP3A activity was evaluated in individuals with (n=38) or without (n=35) type 2 diabetes (T2D). Midazolam was used as a comparator to validate exploratory measures of phenotypic CYP3A activity. Metabolic ratios (MR) of orally administered midazolam in the non-diabetic and diabetic populations correlated significantly with 4β-OHC (r =0. Read More

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http://dx.doi.org/10.1002/cpt.1472DOI Listing

[Corrigendum] Metformin suppresses hypoxia‑induced migration via the HIF‑1α/VEGF pathway in gallbladder cancer in vitro and in vivo.

Oncol Rep 2019 Apr 5. Epub 2019 Apr 5.

Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

The authors have noted that the address given for the Affiliated Hospital of Zhengzhou University in the above article was presented incorrectly: This should have been written as the First Affiliated Hospital of Zhengzhou University. Therefore, the author affiliations for this paper should have appeared as follows: Jianwen Ye1,2, Kunlun Chen1,2, Lei Qi3, Renfeng Li1,2, Hongwei Tang2, Chuang Zhou1,2 and Wenlong Zhai1,2. 1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University; 2Key Laboratory of Digestive Organ Transplantation of Henan Province; Open and Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities; Zhengzhou Key Laboratory of Hepatobiliary and Pancreatic Disease and Organ Transplantation; 3Department of Endocrinology and Metabolism, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P. Read More

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http://dx.doi.org/10.3892/or.2019.7101DOI Listing

Cellular response to glutamine and/or glucose deprivation in in vitro transformed human fibroblasts.

Oncol Rep 2019 Apr 17. Epub 2019 Apr 17.

Institute of Molecular Genetics, Italian National Research Council (CNR), I‑27100 Pavia, Italy.

Neoplastic transformation is characterized by metabolic rewiring to sustain the elevated biosynthetic demands of highly proliferative cancer cells. To obtain the precursors for macromolecule biosynthesis, cancer cells avidly uptake and metabolize glucose and glutamine. Thus, targeting the availability or metabolism of these nutrients is an attractive anticancer therapeutic strategy. Read More

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http://www.spandidos-publications.com/10.3892/or.2019.7125
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http://dx.doi.org/10.3892/or.2019.7125DOI Listing
April 2019
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Longitudinal Muscle and Myocellular Changes in Community-Dwelling Men Over Two Decades of Successful Aging-The ULSAM Cohort Revisited.

J Gerontol A Biol Sci Med Sci 2019 Apr 19. Epub 2019 Apr 19.

Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, and Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.

Participants of the population-based Uppsala longitudinal study of adult men (ULSAM) cohort reaching more than 88 years of age (survivors, S) were investigated at age 70, 82, and 88-90 and compared at 70 years with non-survivors (NS) not reaching 82 years. Body composition, muscle mass and muscle histology were remarkably stable over 18 years of advanced aging in S. Analysis of genes involved in muscle remodeling showed that S had higher mRNA levels of myogenic differentiation factors (Myogenin, MyoD), embryonic myosin (eMyHC), enzymes involved in regulated breakdown of myofibrillar proteins (Smad2, Trim32, MuRF1,) and NCAM compared with healthy adult men (n = 8). Read More

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http://dx.doi.org/10.1093/gerona/glz068DOI Listing

Metabolomics and cytokine analysis for identification of severe drug-induced liver injury.

J Proteome Res 2019 Apr 19. Epub 2019 Apr 19.

Aim: To evaluate the levels of metabolites and cytokines in the serum of patients with severe and non-severe idiosyncratic drug-induced liver injury (DILI), and to identify biomarkers of DILI severity.

Methods: Gas chromatography-mass spectrometry (GC-MS) and ultra-performance liquid chromatography-mass spectrometry (UPLC-MS)-based metabolomic approaches were used to evaluate the metabolome of serum samples from 29 DILI patients of severity grade 3 (non-severe), 27 of severity grade 4 (severe), and 36 healthy controls (HCs). The levels of total Keratin-18 (K18), fragment K18 and 27 cytokines were determined by enzyme-linked immunosorbent assay. Read More

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http://pubs.acs.org/doi/10.1021/acs.jproteome.9b00047
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http://dx.doi.org/10.1021/acs.jproteome.9b00047DOI Listing
April 2019
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Nutrition-related factors associated with waiting list mortality in patients with interstitial lung disease: a retrospective cohort study.

Clin Transplant 2019 Apr 19:e13566. Epub 2019 Apr 19.

Department of Metabolism and Clinical Nutrition, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto-city, Kyoto, Japan.

Japanese patients with interstitial lung disease (ILD) sometimes die waiting for lung transplantation (LTx) because it takes about 2 years to receive it in Japan. We evaluated nutrition-related factors associated with waiting list mortality. Seventy-six ILD patients were hospitalized in Kyoto University Hospital at registration for LTx from 2013 to 2015. Read More

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http://dx.doi.org/10.1111/ctr.13566DOI Listing

PET imaging during hypoglycemia to study adipose tissue metabolism.

Eur J Clin Invest 2019 Apr 19:e13120. Epub 2019 Apr 19.

Departments of Radiology and Nuclear Medicine, Nijmegen, Netherlands.

Background: Disturbances in adipose tissue glucose uptake may play a role in the pathogenesis of type 2 diabetes, yet its examination by 2-deoxy-2-[ F]fluorodeoxyglucose ([ F]FDG) PET/CT is challenged by relatively low uptake kinetics. We tested the hypothesis that performing [ F]FDG PET/CT during a hypoglycemic clamp would improve adipose tissue tracer uptake to allow specific comparison of adipose tissue glucose handling between people with or without type 2 diabetes.

Design: We enrolled participants with or without diabetes who were at least overweight, to undergo a hyperinsulinemic hypoglycemic clamp or a hyperinsulinemic euglycemic clamp (n=5 per group). Read More

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http://dx.doi.org/10.1111/eci.13120DOI Listing

HOXD-AS1: a novel oncogenic long intergenic non-coding RNA in humans.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2898-2907

Department of Hepatobiliary Surgery, Haikou People's Hospital/Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, Haikou, Hainan, P.R. China.

Objective: Long non-coding RNAs are an emerging special class of regulatory RNAs with more than 200 nucleotides that play vital roles in gene regulation, metabolism, drug resistance, cell differentiation, and other processes. These RNAs were also reported to be dysregulated in human disease, especially malignant tumors. However, the underlying mechanisms remain elusive. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17568DOI Listing
April 2019
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[Progression of Chronic Heart Failure: Prognostic Criteria and Non-Drug Prevention].

Kardiologiia 2019 Apr 16;59(4):26-32. Epub 2019 Apr 16.

Republic Scientific and Practical Center "Cardiology", Minsk.

Purpose: to study frequency of progression of chronic heart failure (CHF), to develop multifactorial models for evaluation of risk of progression, and measures of non-drug secondary prevention of CHF.

Materials And Methods: We included in this study 531 patients with functional class (FC) I-III CHF (FC I - n=254, FC II - n=255, FC III - n=22). Examination included clinical-instrumental, clinical-functional, and laboratory (with determination of NT-proBNP concentration) investigations, use of the AUDIT and Morisky Green questionnaires. Read More

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https://lib.ossn.ru/jour/article/view/587
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http://dx.doi.org/10.18087/cardio.2019.4.10248DOI Listing
April 2019
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[Genome-wide identification and expression analysis of gibberellin biosynthesis, metabolism and signaling family genes in Phyllostachys edulis].

Sheng Wu Gong Cheng Xue Bao 2019 Apr;35(4):647-666

State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China.

Gibberellin is an essential plant hormone that plays an important regulatory role throughout the life cycle of higher plants. A total of 23 genes involved in gibberellin action were identified from Phyllostachys edulis genome, including 8 GA20ox and 1 GA3ox genes involved in the gibberellin biosynthesis, 8 GA2ox genes involved in the metabolism of gibberellin, 2 GID1 genes involved in gibberellin perception, 2 GID2 genes and 2 DELLA genes involved in gibberellin signal transduction. Phylogenetic analysis of these genes from Arabidopsis, Oryza sativa and Phyllostachys edulis revealed that gibberellin biosynthesis, metabolism, and signaling pathways are conserved in these species. Read More

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http://dx.doi.org/10.13345/j.cjb.180424DOI Listing

Predictive Factors for Efficacy of AST-120 Treatment in Diabetic Nephropathy: a Prospective Single-Arm, Open-Label, Multi-Center Study.

J Korean Med Sci 2019 Apr 22;34(15):e117. Epub 2019 Apr 22.

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Removal of uremic toxins such as indoxyl sulfate by AST-120 is known to improve renal function and delay the initiation of dialysis in patients with advanced chronic kidney disease. However, it is unclear whether the addition of AST-120 to conventional treatments is effective in delaying the progression of renal dysfunction in patients with diabetic nephropathy.

Methods: A total of 100 patients with type 2 diabetes and renal dysfunction (serum creatinine levels ranging from 1. Read More

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http://dx.doi.org/10.3346/jkms.2019.34.e117DOI Listing

Hepcidin is not essential for mediating testosterone's effects on erythropoiesis.

Andrology 2019 Apr 19. Epub 2019 Apr 19.

Research Program in Men's Health: Aging and Metabolism, The Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.

Background: We have shown that testosterone administration suppresses hepcidin, stimulates iron-dependent erythropoiesis, and increases hemoglobin and hematocrit.

Objective: We investigated whether testosterone-mediated suppression of hepcidin plays an essential role in mediating testosterone's stimulatory effects on erythropoiesis.

Methods: We utilized two mouse models to elucidate the role of hepcidin as a mediator of testosterone's effects on erythropoiesis: First, we used a whole-body hepcidin knockout (HepKO) mouse. Read More

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http://dx.doi.org/10.1111/andr.12622DOI Listing
April 2019
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