1,001 results match your criteria Metabolic Syndrome and Related Disorders [Journal]


Moderate Serum γ-Glutamyl Transferase Level Is Beneficial for Heart Failure After Percutaneous Coronary Intervention.

Metab Syndr Relat Disord 2019 Apr 16. Epub 2019 Apr 16.

2 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China.

Objective: Previous studies suggested that elevated serum γ-glutamyl transferase (GGT) level is an independent predictor of coronary artery disease (CAD) and heart failure (HF). However, whether serum GGT level has a predictive role for HF after percutaneous coronary intervention (PCI) remains unclear. This study aimed to evaluate the association of GGT with HF after PCI in a Chinese population. Read More

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http://dx.doi.org/10.1089/met.2019.0009DOI Listing

Lower Relative Handgrip Strength is Significantly Associated with a Higher Prevalence of the Metabolic Syndrome in Adults.

Metab Syndr Relat Disord 2019 Apr 4. Epub 2019 Apr 4.

1 Department of Sport Industry Studies, Yonsei University, Seoul, South Korea.

Purpose: In previous studies, there were debates on the association between handgrip strength (HGS) and prevalence of metabolic syndrome. Since body weight is associated with both HGS and prevalence of metabolic syndrome, whether HGS is corrected with body weight (relative HGS) or not (absolute HGS) can directly influence outcome of the study. Therefore, this study analyzed the relationship between HGS and prevalence of metabolic syndrome using both relative and absolute HGS. Read More

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http://dx.doi.org/10.1089/met.2018.0111DOI Listing
April 2019
1.916 Impact Factor

The Role of Visceral Adiposity Index Levels in Predicting the Presence of Metabolic Syndrome and Insulin Resistance in Overweight and Obese Patients.

Metab Syndr Relat Disord 2019 Mar 30. Epub 2019 Mar 30.

1 The Department of Family Medicine, Konya Health Application and Research Center, University of Health Sciences, Konya, Turkey.

Background: To investigate visceral adiposity index (VAI) levels in obese patients with and without metabolic syndrome (MetS) and its relationship with insulin resistance (IR), and define cutoff value of VAI in the determination of patients with MetS and IR.

Methods: Aged between 18 and 65, 92 patients with obesity were included. Levels of homeostasis model assessment of IR (HOMA-IR) and VAI were calculated. Read More

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http://dx.doi.org/10.1089/met.2019.0005DOI Listing
March 2019
4 Reads

Metabolic Syndrome in Endometrial Cancer Patients: Systematic Review.

Metab Syndr Relat Disord 2019 Mar 30. Epub 2019 Mar 30.

1 Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, Pennsylvania.

Large numbers of previously published studies show the importance of Metabolic syndrome (MetS) in the development of endometrial cancer (EC), the most common gynecologic malignancy in the United States. Defining the association between EC and MetS is complicated by inconsistencies among the MetS definitions used in EC. The aim of this study was to identify the MetS definition that is most practical for EC patients, as well as to estimate the prevalence of MetS using each definition in EC patients. Read More

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http://dx.doi.org/10.1089/met.2018.0106DOI Listing
March 2019
7 Reads

Prevalence of and Factors Associated with Metabolic Syndrome in Afro-Descendant Communities in a Situation of Vulnerability in Northern Brazil: A Cross-Sectional Study.

Metab Syndr Relat Disord 2019 Mar 20. Epub 2019 Mar 20.

1 Laboratório de Epidemiologia e Análise de dados, Faculdade de Medicina do ABC, Santo André, Brazil.

Background: Quilombos are Brazilian communities developed by survivor groups following fight against slavery. They are found in the whole of the Brazilian territory, far from urban centers, living in vulnerable and poor socioeconomic situations and continuously suffering from influence of occidentalization. Based on the hypothesis that the way Quilombolas live may be associated with metabolic syndrome (MS), the objective of this study was to estimate the prevalence of MS and to analyze the associated factors in adult residents of Quilombola communities in the northern region of Brazil. Read More

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http://dx.doi.org/10.1089/met.2018.0107DOI Listing

Cardiometabolic Proteins Associated with Metabolic Syndrome.

Metab Syndr Relat Disord 2019 Mar 18. Epub 2019 Mar 18.

3 Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.

Background: Although metabolic syndrome (MetS) was described in the late 80s, the molecular mechanisms underlying clustering of risk factors in certain individuals are not fully understood. The present study used targeted proteomics to establish cardiometabolic proteins related to all MetS components, thereby providing new hypotheses regarding pathways involved in the pathogenesis of MetS.

Methods: In the EpiHealth study, 249 cardiometabolic proteins were measured by proximity extension assay (PEA) and related to the five MetS components [consensus-modified National Cholesterol Education Program (NCEP) criteria] in 2,444 participants aged 45-75 years (50% women). Read More

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http://dx.doi.org/10.1089/met.2018.0123DOI Listing

Metabolically Healthy Obesity Is Characterized by a Proinflammatory Phenotype of Circulating Monocyte Subsets.

Metab Syndr Relat Disord 2019 Mar 13. Epub 2019 Mar 13.

1 Department of Endocrinology, University of Ioannina, Ioannina, Greece.

Background: Obesity is associated with macrophage infiltration in adipose tissue that induces insulin resistance and contributes to the development of metabolic syndrome (MS). The aim of this study was to investigate whether circulating monocyte subsets (macrophage precursors) differ among obese subjects with MS [metabolically unhealthy obese (MUO)], obese subjects without MS [metabolically healthy obese (MHO)], and metabolically healthy lean (MHL) individuals.

Methods: Fifty-eight obese (33 MUO, 25 MHO) and 25 MHL individuals participated in the study. Read More

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http://dx.doi.org/10.1089/met.2018.0132DOI Listing
March 2019
1 Read

Body Weight Reduction of 5% Improved Blood Pressure and Lipid Profiles in Obese Men and Blood Glucose in Obese Women: A Four-Year Follow-up Observational Study.

Metab Syndr Relat Disord 2019 Mar 6. Epub 2019 Mar 6.

1 Department of Diabetology and Metabolism, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.

Background: Body weight reduction (BWR) of at least 3% in obese Japanese individuals through lifestyle interventions has improved the risk factors for cardiovascular disease (CVD). We aimed to assess the relation between body weight change (BWC) and CVD risk change and to identify lifestyle improvement related to BWR in obese Japanese individuals.

Methods: Subjects were 2579 health checkup examinees without medicated diabetes, hypertension or dyslipidemia, and a body mass index ≥25 kg/m who completed lifestyle questionnaires in 2008 and 2012. Read More

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http://dx.doi.org/10.1089/met.2018.0115DOI Listing
March 2019
2 Reads

A Tale of Three Gorges in the Yangtze River: Comparing the Prevalence of Metabolic Syndrome According to ATPIII, WHO, and IDF Criteria and the Association with Vascular Health in Modernizing China.

Metab Syndr Relat Disord 2019 Apr 5;17(3):137-142. Epub 2019 Mar 5.

7 Department of Cardiology, The University of Sydney, Sydney, Australia.

Background: Metabolic syndrome (MS) is associated with atherosclerotic diseases. The prevalence of MS according to the Adult Treatment Panel III (ATPIII), World Health Organization (WHO), and International Diabetes Federation (IDF) criteria are variable but increasing in western countries and modernizing China. This study aimed to evaluate the prevalence of MS according to these three criteria, in farmers or ex-farming residents in three-gorges territories undergoing rapid lifestyle changes. Read More

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http://dx.doi.org/10.1089/met.2018.0091DOI Listing
April 2019
2 Reads

Performance of Anthropometric Indicators in the Prediction of Metabolic Syndrome in the Elderly.

Metab Syndr Relat Disord 2019 Feb 26. Epub 2019 Feb 26.

1 Graduate Program in Biomedical Gerontology, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.

Introduction: Studies have demonstrated the relevance of anthropometric indicators in the prediction of metabolic syndrome (MetS). However, researches involving older people are still scarce. Therefore, the objective was to describe the frequency of MetS and to determine the performance of anthropometric indicators as predictors of MetS in the total sample, in men and women. Read More

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http://dx.doi.org/10.1089/met.2018.0113DOI Listing
February 2019

Influence of K656N Polymorphism of the Leptin Receptor Gene on Obesity-Related Traits in Nondiabetic Afro-Caribbean Individuals.

Metab Syndr Relat Disord 2019 Feb 26. Epub 2019 Feb 26.

1 Research Team on Cardiometabolic Risk ECM/LAMIA EA4540, University of Antilles, Pointe-à-Pitre, Guadeloupe, FWI, France.

Background: Ethnic variations have been reported in allelic frequencies of the leptin receptor gene (LEPR) with population-specific effects. We aimed to explore the association of LEPR polymorphisms with obesity, metabolic syndrome (MetS), and leptin levels in Afro-Caribbean nondiabetic subjects.

Methods: Genotypic analysis of three LEPR polymorphisms (K109R, Q223R, and K656N) was performed using TaqMan allelic discrimination assays. Read More

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http://dx.doi.org/10.1089/met.2018.0133DOI Listing
February 2019

Benefits of 1-Year Lifestyle Modification Program on Exercise Capacity and Diastolic Function Among Coronary Artery Disease Men With and Without Type 2 Diabetes.

Metab Syndr Relat Disord 2019 Apr 21;17(3):149-159. Epub 2019 Feb 21.

1 Department of Cardiology, Quebec Heart and Lung Institute, Quebec, Canada.

Background: To assess the benefits of a 1-year lifestyle modification program on exercise capacity and diastolic function in men with left ventricular (LV) diastolic dysfunction (LVDD) and coronary artery disease (CAD), according to glucose tolerance status.

Methods: Fifty-three men (62 ± 8 years; BMI: 27.3 ± 3. Read More

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http://dx.doi.org/10.1089/met.2018.0092DOI Listing

Association Between Thyroid Nodules and Volume and Metabolic Syndrome in an Iodine-Adequate Area: A Large Community-Based Population Study.

Metab Syndr Relat Disord 2019 Feb 11. Epub 2019 Feb 11.

1 Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Background: Given its high incidence, thyroid nodule (TN) warrants public attention. Thyroid volume (TV) has also been associated with multiple factors, such as iodine deficiency and supply and body mass index. It is well known that metabolic syndrome (MetS) comprises many metabolic disturbances, with insulin resistance being its major component. Read More

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http://dx.doi.org/10.1089/met.2018.0094DOI Listing
February 2019
1 Read

Comparison of Body Mass Index Percentiles to Detect Metabolic Syndrome Using the Korean, United States Centers for Disease Control and Prevention, and World Health Organization References in Korean Children Aged 10-16 Years.

Authors:
Kayoung Lee

Metab Syndr Relat Disord 2019 Feb 11. Epub 2019 Feb 11.

Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.

Background: Few studies have compared the local and international body mass index (BMI) reference sets for their relationship with metabolic syndrome (MetS) in children. This study aimed to compare the BMI percentiles using Korean, United States Centers for Disease Control and Prevention (US-CDC), and World Health Organization (WHO) charts for their ability to detect MetS in Korean children and examine their associations with the severity of MetS.

Methods: Among 3094 children (1653 boys, age: 10-16 years) from the Korean National Health and Examination Survey 2011-2016, age and sex-specific BMI percentiles using the three charts (Korean, US-CDC, and WHO charts) were determined. Read More

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http://dx.doi.org/10.1089/met.2018.0126DOI Listing
February 2019
1 Read

Changes in Cardiovascular Disease Risk Factors with Unintentional Versus Intentional Weight Loss: The Coronary Artery Risk Development in Young Adults Study.

Metab Syndr Relat Disord 2019 Apr 7;17(3):143-148. Epub 2019 Feb 7.

1 Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: It is well known that total and intentional weight loss (IWL) are associated with reductions in cardiovascular disease (CVD) risk factors, however, associations with unintentional weight loss (UWL) have not been studied.

Methods: We examined annual changes in blood pressure and lipids associated with UWL versus IWL in 576 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study who had lost weight over one of two time intervals (i.e. Read More

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http://dx.doi.org/10.1089/met.2018.0114DOI Listing
April 2019
1 Read

The Effect of Proton Pump Inhibitors on Glycemic Control in Patients with Type 2 Diabetes.

Metab Syndr Relat Disord 2019 Feb 7. Epub 2019 Feb 7.

2 Medical Service, VA Northern California Health Care System, Martinez, California.

Background: Type 2 diabetes patients have decreased pancreatic beta cell mass with a decline in beta cell function. Gastrin has increased beta cell proliferation in vitro and in animal studies. High gastric acid levels inhibit gastrin secretion. Read More

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http://dx.doi.org/10.1089/met.2018.0138DOI Listing
February 2019
1 Read

The Role of Glucagon-Like Peptide-1 in Energy Homeostasis.

Metab Syndr Relat Disord 2019 Feb 5. Epub 2019 Feb 5.

3 The Knight Cardiovascular Institute, Mailcode MDYMI, Oregon Health and Science University, Portland, Oregon.

Energy homeostasis is coordinated by bidirectional communication pathways between the brain and peripheral organs, including adipose tissue, muscle, the pancreas, liver, and gut. Disruption of the integrated chemical, hormonal, and neuronal signals that constitute the gut-brain axis significantly contributes to disorders of metabolism and body weight. Initial studies of glucagon-like peptide-1 (GLP-1), a gut hormone released in response to the ingestion of nutrients, focused on its incretin actions to improve postprandial glucose homeostasis by enhancing meal-induced insulin secretion. Read More

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http://dx.doi.org/10.1089/met.2018.0088DOI Listing
February 2019
2 Reads

Age, Sex, and Cardiovascular Risk Attributable to Lipoprotein Cholesterol Among Chinese Individuals with Coronary Artery Disease: A Case-Control Study.

Metab Syndr Relat Disord 2019 Feb 5. Epub 2019 Feb 5.

1 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China.

Aim: To understand age- and gender-related differences and secular trends in coronary artery disease (CAD) lipid profiles and the characteristic of dyslipidemia in western China.

Methods: An age-matched case-control study, including 2400 patients and 1200 controls was performed. All blood lipid tests evaluated from January 2012 to January 2015 at First Affiliated Hospital of Xinjiang Medical University were analyzed. Read More

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http://dx.doi.org/10.1089/met.2018.0067DOI Listing
February 2019
1 Read

Even Short-Term Telmisartan Treatment Ameliorated Insulin Resistance But Had No Influence on Serum Adiponectin and Tumor Necrosis Factor-Alpha Levels in Hypertensive Patients with Metabolic Syndrome.

Metab Syndr Relat Disord 2019 Apr 28;17(3):167-172. Epub 2019 Jan 28.

4 Department of Endocrinology and Metabolism, Medical Faculty, Uludag University, Bursa, Turkey.

Background: We investigated the effect of short-term telmisartan usage in addition to lifestyle changes such as diet and exercise on insulin resistance, lipid metabolism, and serum adiponectin and tumor necrosis factor-alpha (TNF-α) levels in hypertensive patients with metabolic syndrome (MetS).

Methods: A total of 36 hypertensive patients with MetS were randomized to telmisartan and control groups in an open-labeled prospective study.

Results: There were significant decreases in anthropometric variables of patients according to baseline measurements in both groups at the end of the study. Read More

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http://dx.doi.org/10.1089/met.2018.0129DOI Listing

Salt, Hypertension, and the Lens.

Metab Syndr Relat Disord 2019 Apr 22;17(3):173-181. Epub 2019 Jan 22.

2 Urfa Education and Training Hospital, University of Health Sciences, Urfa, Turkey.

Background: Salt is important in the pathogenesis of hypertension (HT). Salt-sensitive hypertension (SSH) accounts for about half of all HT cases. In SSH, sodium/potassium adenosine triphosphatase (Na/K-ATPase) activity is impaired. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0117
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http://dx.doi.org/10.1089/met.2018.0117DOI Listing
April 2019
5 Reads

The Relationship Between Housing Types and Metabolic and Weight Phenotypes: A Nationwide Survey.

Authors:
Kayoung Lee

Metab Syndr Relat Disord 2019 Apr 22;17(3):129-136. Epub 2019 Jan 22.

Department of Family Medicine, College of Medicine, Busan Paik Hospital, Inje University, Busan, Republic of Korea.

Background: Compared to studies evaluating the effect of environmental factors on weight and health, relationships between housing types and health conditions are understudied. This study aimed to assess the relationship between housing types and metabolic and weight phenotypes using data from the 2014 to 2015 Korea National Health and Nutrition Examination Survey.

Methods: A total of 9586 Korean adults (4128 men and 5458 women; mean age, 50. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0109
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http://dx.doi.org/10.1089/met.2018.0109DOI Listing
April 2019
9 Reads

Metabolic Health in Severely Obese Subjects: A Descriptive Study.

Metab Syndr Relat Disord 2019 Mar 16;17(2):115-119. Epub 2019 Jan 16.

3 Steno Diabetes Center Copenhagen, Gentofte, Denmark.

Background: The prevalence of metabolically healthy obese (MHO) subjects among morbidly obese subjects is poorly described.

Aim: To describe the prevalence of metabolically healthy subjects in a group of morbidly obese referred for bariatric surgery.

Methods: Descriptive cross-sectional study, 1209 subjects (825 women/384 men) mean body mass index (BMI) of 45. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0083
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http://dx.doi.org/10.1089/met.2018.0083DOI Listing
March 2019
4 Reads

Determinants of Changes in Metabolic Syndrome Components in a 12-Year Cohort of Iranian Adults.

Metab Syndr Relat Disord 2019 Mar 8;17(2):120-127. Epub 2019 Jan 8.

1 Public Health, School of Medicine and Menzies Health Institute Queensland, Griffith University, Southport, Australia.

Background: The prevalence of metabolic syndrome (MetS) and its components have been increasing globally; therefore, there is a need for better understanding of MetS components and their risk factors, as well as their development and changes over time. This study was designed to identify the determinants of the changes in the components of MetS in a cohort of Iranian adults from 2001 to 2013.

Methods: A total of 6504 adults, ≥35 years of age, were recruited from central Iran in 2001and were followed up in an ongoing longitudinal population-based study for 12 years. Read More

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http://dx.doi.org/10.1089/met.2018.0026DOI Listing

Assessment of Arterial Stiffness in Metabolic Syndrome Related to Insulin Resistance in Apparently Healthy Men.

Metab Syndr Relat Disord 2019 Mar 8;17(2):90-96. Epub 2019 Jan 8.

3 Division of Metabolic Diseases, Epidemiology Research Center, AJA University of Medical Science, Tehran, Iran.

Background: Assessment of subclinical atherosclerosis in metabolic syndrome is one of the global health targets' priorities. This study aimed to evaluate the subclinical atherosclerosis in metabolic syndrome related to insulin resistance in healthy and physically active men.

Methods: A consecutive group of 68 healthy men, 30-55 years of age, was studied. Read More

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http://dx.doi.org/10.1089/met.2018.0090DOI Listing
March 2019
3 Reads
1.916 Impact Factor

The Relationship Between Cardiorespiratory Fitness and Arterial Stiffness in Middle-Aged Men with Abdominal Obesity.

Metab Syndr Relat Disord 2019 Mar 8;17(2):97-101. Epub 2019 Jan 8.

Department of Sports Medicine Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Abdominal obesity increases rapidly after middle age in Korean men, and there is an associated trend toward increasing levels of cardiovascular disease (CVD). The purpose of this study was to examine the effect of cardiorespiratory fitness (CRF) on arterial stiffness in men with abdominal obesity.

Methods: A total of 387 middle-aged men (ages 42-59 years) with abdominal obesity participated in this cross-sectional study. Read More

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http://dx.doi.org/10.1089/met.2018.0068DOI Listing
March 2019
2 Reads

Prevalence of Metabolic Syndrome and Its Relation to Physical Activity and Nutrition in Azerbaijan.

Metab Syndr Relat Disord 2019 Apr 8;17(3):160-166. Epub 2019 Jan 8.

1 Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey.

Background: Metabolic syndrome (MetS) is an important public health concern associated with an increased risk for cardiovascular disease and type 2 diabetes. Despite its global significance, the prevalence of MetS in Azerbaijan is unknown. The purpose of this study was to examine the prevalence of MetS and its relation to physical activity (PA) and nutrition in a representative sample of Azerbaijani adults. Read More

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http://dx.doi.org/10.1089/met.2018.0096DOI Listing
April 2019
1 Read

Pubertal Status and Gonadal Functions in Obese Boys with Fatty Liver.

Metab Syndr Relat Disord 2019 Mar 7;17(2):102-107. Epub 2019 Jan 7.

1 Department of Biochemistry, University of Health Sciences, Konya Training and Research Hospital, Konya, Turkey.

Background: In adult studies, obese subjects with nonalcoholic fatty liver disease (NAFLD) have been shown to have poor sperm quality, and lower testosterone and luteinizing hormone levels. The aim of this study was to investigate the pubertal status and gonadal functions in obese boys with NAFLD.

Materials And Methods: The study included 119 obese and 78 nonobese age-matched adolescents. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0050
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http://dx.doi.org/10.1089/met.2018.0050DOI Listing
March 2019
14 Reads

Serum Uric Acid to Creatinine Ratio Independently Predicts Incident Metabolic Syndrome Among Community-Dwelling Persons.

Metab Syndr Relat Disord 2019 Mar 7;17(2):81-89. Epub 2019 Jan 7.

1 Department of Community Medicine, Ehime University Graduate School of Medicine, Toon, Japan.

Background: Metabolic syndrome (MetS) is related to the increased risk of major cardiovascular disease. The link between high serum uric acid (SUA) and creatinine (Cr) levels is causally related to MetS and its components. However, whether renal function-normalized SUA [i. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0055
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http://dx.doi.org/10.1089/met.2018.0055DOI Listing
March 2019
10 Reads

Effects of the Relative Distribution of Body Mass Index on the Incidence of Hypertension and Diabetes Mellitus, Using the Korean Obesity Index.

Metab Syndr Relat Disord 2019 Mar 13;17(2):108-114. Epub 2018 Dec 13.

Big Data Steering Department, National Health Insurance Service, Wonju, Korea.

Background: The Korean Obesity Index, which contains standard reference data (SRD) of obesity, was established in 2016 and revised in 2017 based on national health screening data to provide the distribution of the body mass index (BMI) of the whole population of Korea as a reference. This study aimed to investigate the effect of the SRD of obesity on the incidence of hypertension (HTN) and diabetes mellitus (DM).

Methods: The percentile of BMI was calculated for each of the 864 subgroups by defined by gender, region, and age group according to the groupings in the SRD. Read More

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http://dx.doi.org/10.1089/met.2018.0104DOI Listing

Prevalence of Optimal Metabolic Health in American Adults: National Health and Nutrition Examination Survey 2009-2016.

Metab Syndr Relat Disord 2019 Feb 27;17(1):46-52. Epub 2018 Nov 27.

1 Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: Several guidelines for cardiometabolic risk factor identification and management have been released in recent years, but there are no estimates of current prevalence of metabolic health among adults in the United States. We estimated the proportion of American adults with optimal cardiometabolic health, using different guidelines.

Methods: Data from the National Health and Nutrition Examination Survey 2009-2016 were analyzed (n = 8721). Read More

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http://dx.doi.org/10.1089/met.2018.0105DOI Listing
February 2019

Brain-Derived Neurotrophic Factor and Its Associations with Metabolism and Physical Activity in a Latino Sample.

Metab Syndr Relat Disord 2019 Mar 10;17(2):75-80. Epub 2018 Nov 10.

2 Mayo Clinic Translational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, Arizona.

Background: Brain-derived neurotrophic factor (BDNF) is associated with body weight and other health conditions but remains understudied in the Latino population. The aim of this study was to examine the associations of BDNF serum levels with body mass index (BMI), physical activity, and the rs6265 nonconservative polymorphism among 349 Latinos aged ≥18 years enrolled in the Arizona Insulin Resistance Registry.

Materials And Methods: Data on physical activity were acquired using a self-reported questionnaire. Read More

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http://dx.doi.org/10.1089/met.2018.0028DOI Listing

Prediction of Insulin Resistance with Anthropometric and Clinical Laboratory Measures in Nondiabetic Teenagers.

Metab Syndr Relat Disord 2019 Feb 3;17(1):37-45. Epub 2018 Nov 3.

3 Department of Research, Womack Army Medical Center, Fort Bragg, North Carolina.

Background: Adolescent obesity is an important risk factor for cardiovascular disease in part due to its relationship to type 2 diabetes. Therefore, screening for type 2 diabetes is recommended. However, since insulin resistance (IR) is an early precursor of diabetes, it would be beneficial if IR predictors from routine assessments could identify those at greatest metabolic risk before diabetes has developed. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0072
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http://dx.doi.org/10.1089/met.2018.0072DOI Listing
February 2019
13 Reads

A Global MicroRNA Profile in Fanconi Anemia: A Pilot Study.

Metab Syndr Relat Disord 2019 Feb 30;17(1):53-59. Epub 2018 Oct 30.

1 Mutagenesis and Preventive Oncology, Ospedale Policlinico San Martino, Genova, Italy.

Purpose: Fanconi anemia (FA) is a complex tumor-prone disease defined by an entangled genotype and phenotype. Despite enormous efforts in the last 20 years, a comprehensive and integrated view of the disease is still missing. The aim of this pilot study was to establish whether a global microRNA (miRNA) analysis approach could be helpful in defining aspects in FA phenotype, which might deserve future attention with the perspective to develop miRNA-based therapies. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0085
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http://dx.doi.org/10.1089/met.2018.0085DOI Listing
February 2019
21 Reads

The Association Between Metabolic Syndrome and Serum Concentrations of Micronutrients, Inflammation, and Oxidative Stress Outside of the Clinical Reference Ranges: A Cross-Sectional Study.

Metab Syndr Relat Disord 2019 Feb 27;17(1):29-36. Epub 2018 Oct 27.

1 School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.

Background: Clinical reference ranges are often used to assess nutritional status, but whether having lower or higher than the current clinical reference range for micronutrients, inflammation, and oxidative stress is related to metabolic syndrome (MetS) is not known. Our objectives are to estimate the odds of having MetS outside of established clinical references, and to identify any effect modifications by sex have for these relationships.

Methods: Data from the 2005 to 2006 National Health and Nutrition Examination Survey were used (≥20 years; N = 2049) with MetS defined utilizing the harmonized criteria from the Joint Interim Statement. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0080
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http://dx.doi.org/10.1089/met.2018.0080DOI Listing
February 2019
10 Reads

Plasma Growth Arrest-Specific 6 Protein and Genetic Variations in the GAS6 Gene in Patients with Metabolic Syndrome.

Metab Syndr Relat Disord 2019 Feb 20;17(1):22-28. Epub 2018 Oct 20.

1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background: Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted by immune cells, endothelial cells, vascular smooth muscle cells, and adipocytes. Recent studies indicate that Gas6 and receptors of the TAM (Tyro3, Axl, and Mer) family may be involved in the pathogenesis of obesity, systemic inflammation, and insulin resistance. The aim of this study was to investigate the association between plasma Gas6 protein and the c. Read More

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http://dx.doi.org/10.1089/met.2017.0143DOI Listing
February 2019
1 Read

Growth Hormone Deficiency and Nonalcoholic Fatty Liver Disease with Insights from Humans and Animals: Pediatric Implications.

Authors:
Rohan K Henry

Metab Syndr Relat Disord 2018 Oct 20. Epub 2018 Oct 20.

Division of Endocrinology, Department of Pediatrics, Nationwide Children's Hospital/The Ohio State University College of Medicine , Columbus, Ohio.

In addition to its growth promoting role, growth hormone (GH) has a significant effect on intermediary metabolism in the well state. Despite the latter fact, pediatric practitioners are usually focused on the growth promoting aspects of GH as opposed to those metabolic. In recent years various animal and human studies (in adults mainly) and clinical reports in children have repeatedly shown the association of GH deficiency (GHD) and fatty liver disease. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0056
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http://dx.doi.org/10.1089/met.2018.0056DOI Listing
October 2018
14 Reads

Acute Physical Effort Increases Sympathovagal Balance Responses to Autonomic Stimulation in Metabolic Syndrome.

Metab Syndr Relat Disord 2019 Feb 17;17(1):67-74. Epub 2018 Oct 17.

3 Centre of Human and Applied Physiological Sciences, Department of Physiology, School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

Background: There is little evidence of how metabolic syndrome (MS) affects sympathovagal balance responses to acute physical effort (APE) and autonomic stimulation (AS). This study aimed to evaluate the heart rate variability (HRV) responses to the combined APE and AS challenges.

Methods: Fourteen subjects (8 men; 49. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0065
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http://dx.doi.org/10.1089/met.2018.0065DOI Listing
February 2019
5 Reads

Determinants of Fasting Hyperglucagonemia in Patients with Type 2 Diabetes and Nondiabetic Control Subjects.

Metab Syndr Relat Disord 2018 12 16;16(10):530-536. Epub 2018 Oct 16.

1 Clinical Metabolic Physiology, Steno Diabetes Center Copenhagen, Gentofte Hospital, Hellerup, Denmark .

Background: Fasting hyperglucagonemia can be detrimental to glucose metabolism in patients with type 2 diabetes (T2D) and may contribute to metabolic disturbances in obese and/or prediabetic subjects. However, the mechanisms underlying fasting hyperglucagonemia remain elusive.

Methods: We evaluated the interrelationship between fasting hyperglucagonemia and demographic and biochemical parameters in 106 patients with T2D (31% female, age: 57 ± 9 years [mean ± standard deviation; body mass index (BMI): 30. Read More

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http://dx.doi.org/10.1089/met.2018.0066DOI Listing
December 2018
6 Reads

Diabetes Is Associated with Cognitive Decline in Middle-Aged Patients.

Metab Syndr Relat Disord 2018 Oct 11. Epub 2018 Oct 11.

1 Escuela de Medicina, Universidad Catolica Santiago de Guayaquil , Guayaquil, Ecuador .

Background: Diabetes is a major contributor to dementia in the elderly. Identifying mild cognitive decline in younger individuals with diabetes could aid in preventing the progression of the disease. The aim of our study is to compare whether patients with diabetes experience greater cognitive decline than those without diabetes. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0014
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http://dx.doi.org/10.1089/met.2018.0014DOI Listing
October 2018
19 Reads

Hypertensive Waist and Lipid Accumulation Product as Predictors of Metabolic Syndrome.

Metab Syndr Relat Disord 2018 12 6;16(10):505-506. Epub 2018 Oct 6.

1 Department of Diabetes and Nutrition, Iuliu Hatieganu University of Medicine and Pharmacy , Cluj-Napoca, Romania .

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https://www.liebertpub.com/doi/10.1089/met.2018.0098
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http://dx.doi.org/10.1089/met.2018.0098DOI Listing
December 2018
3 Reads

Relationship Between Obesity and Lumbar Spine Degeneration: A Cross-Sectional Study from the Fifth Korean National Health and Nutrition Examination Survey, 2010-2012.

Metab Syndr Relat Disord 2019 Feb 6;17(1):60-66. Epub 2018 Oct 6.

2 Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background: Although several studies have shown that obesity affects low back pain (LBP), the relationship between degenerative lumbar spine (LSD) and obesity has not been fully investigated. This study evaluated whether obesity is independently associated with LSD in the general population.

Methods: This cross-sectional study used public data from the Fifth Korean National Health and Nutrition Examination Survey (2010-2012). Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0051
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http://dx.doi.org/10.1089/met.2018.0051DOI Listing
February 2019
3 Reads

Objectively Measured Physical Activity, Sedentary Behavior, and Metabolic Syndrome in Adults: Systematic Review of Observational Evidence.

Metab Syndr Relat Disord 2019 Feb 29;17(1):1-21. Epub 2018 Sep 29.

School of Nutrition and Dietetics, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Kuala Nerus, Terengganu, Malaysia.

Objective measurement of physical activity (PA) and sedentary behavior (SB) associated with metabolic syndrome (MetS) has gained more attention among researchers in recent years. Although almost similar trends of results have been reported worldwide, they were not always statistically significant. This systematic review summarizes the evidence of observational studies reporting the associations between objectively measured PA, SB, and MetS in adults. Read More

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http://dx.doi.org/10.1089/met.2018.0032DOI Listing
February 2019
19 Reads

Gender as an Independent Risk Factor for the Components of Metabolic Syndrome Among Individuals Within the Normal Range of Body Mass Index.

Metab Syndr Relat Disord 2018 Sep 11. Epub 2018 Sep 11.

1 Department of Medicine F - Recanati and Clinical Pharmacology Unit, Rabin Medical Center (Beilinson Hospital) , Petah Tikva, Israel .

Background: Overweight and obesity are more common in men than in women. This explains the higher prevalence of risk factors for metabolic syndrome (MetS) found in men. We aimed to assess whether gender, per se, might be an independent risk factor for the components of MetS in a large cohort of subjects within the normal range of body mass index (BMI). Read More

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http://dx.doi.org/10.1089/met.2018.0071DOI Listing
September 2018

Predictive Value of Lipid Accumulation Product, Fatty Liver Index, Visceral Adiposity Index for Metabolic Syndrome According to Menopausal Status.

Metab Syndr Relat Disord 2018 11 5;16(9):477-482. Epub 2018 Sep 5.

Department of Obstetrics and Gynecology, School of Medicine, Medical Research Institute, Pusan National University Hospital , Busan, Korea.

Background: The aim of this study is to investigate the value of clinical indicators of metabolic syndrome according to menopausal status in healthy Korean women.

Methods: The study included 3936 female patients who were managed at Pusan National University Hospital Health Promotion Center from 2008 to 2014. Each patient completed self-report questionnaires and underwent personal interviews with a healthcare provider to assess their past medical history such as any previous disease, medication and/or menstrual histories along with the measurement of her current body size. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0019
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http://dx.doi.org/10.1089/met.2018.0019DOI Listing
November 2018
10 Reads

Determining Factors of Arterial Stiffness in Subjects with Metabolic Syndrome.

Metab Syndr Relat Disord 2018 11 5;16(9):490-496. Epub 2018 Sep 5.

6 Clinical Center of Diabetes, Nutrition, Metabolic Diseases, "Iuliu Haţieganu" University of Medicine and Pharmacy , Cluj-Napoca, Romania .

Background: Metabolic syndrome (MS) is a clustering entity characterized by obesity, hypertension, hyperglycemia, dyslipidemia, and insulin resistance. Early detection of atherosclerosis is important in patients with MS because cardiovascular diseases are the main cause of mortality in these patients.

Methods: We aimed to investigate the factors influencing arterial stiffness, pulse wave velocity, and the augmentation index, respectively, in 150 subjects with MS (94 women and 56 men; mean age 60. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0057
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http://dx.doi.org/10.1089/met.2018.0057DOI Listing
November 2018
8 Reads

Can the Plasma Concentration Ratio of Triglyceride/High-Density Lipoprotein Cholesterol Identify Individuals at High Risk of Cardiovascular Disease During 40-Year Follow-Up?

Metab Syndr Relat Disord 2018 10 5;16(8):433-439. Epub 2018 Sep 5.

2 Department of Medicine, Stanford University , Stanford, California.

Background: The plasma concentration ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) is a simple way to estimate insulin resistance. We aimed to evaluate the TG/HDL-C ratio as a simple clinical way to identify apparently healthy individuals with insulin resistance and enhanced risk of future cardiovascular disease (CVD).

Methods: One thousand seven hundred twenty men, aged 50 years, free from diabetes and CVD when evaluated at baseline in 1970-1974 were followed for 40 years regarding incident CVD (myocardial infarction and/or ischemic stroke, n = 576). Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0058
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http://dx.doi.org/10.1089/met.2018.0058DOI Listing
October 2018
7 Reads

Detection of Glycemia and Osmolarity Changes Using Eye Examinations.

Metab Syndr Relat Disord 2018 Sep 5. Epub 2018 Sep 5.

4 Department of Ophthalmology, Keçiören Education and Training Hospital, University of Health Sciences, Ankara, Turkey .

Background: Glycated hemoglobin (HbA1c) is an index of the average blood glucose level over the preceding 2-3 months. In experimental studies, the lens responded to changes in osmolarity by forming vacuoles. By observing the vacuoles of the lens during eye examination, can we detect changes in osmolarity and glycemia over the last 6 months through HbA1c levels?

Methods: In total, 400 patients (mean age, 67. Read More

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http://dx.doi.org/10.1089/met.2018.0076DOI Listing
September 2018
4 Reads

Obesity, Visceral Fat, and Hypertension-Related Complications.

Metab Syndr Relat Disord 2018 Sep 5. Epub 2018 Sep 5.

1 Department of Cardiology, School of Health Sciences, Medical University of Silesia , Katowice, Poland .

Background: Hypertension and obesity are very common and complex cardiovascular (CV) risk factors. Our aim was to provide a comprehensive assessment of associations between visceral fat depots and vascular or cardiac complications of hypertension.

Methods: All the consecutive patients (age: 45-80 years old) scheduled for elective coronary angiography in the Department of Cardiology were screened, and 400 patients were included into the study group. Read More

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http://dx.doi.org/10.1089/met.2018.0062DOI Listing
September 2018
2 Reads
1.916 Impact Factor

High Body Mass Index Masks Body Composition Differences in Physically Active Versus Sedentary Participants.

Metab Syndr Relat Disord 2018 11 21;16(9):483-489. Epub 2018 Aug 21.

1 Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota , Minnesota, Minneapolis.

Background: Despite the benefits of aerobic exercise on body composition, runners with high body mass index (BMI) remain understudied. We examined body composition differences between sedentary insulin-resistant [obese insulin-resistant sedentary (OS-IR)], sedentary insulin-sensitive [obese insulin-sensitive sedentary (OS-IS)], and trained [obese trained (OT)] individuals with high BMI (≥25 kg/m). We hypothesized that after matching for high BMI, OT individuals would have less fat mass (absolute and relative) and greater lean mass than OS-IR or OS-IS individuals. Read More

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http://www.liebertpub.com/doi/10.1089/met.2018.0042
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http://dx.doi.org/10.1089/met.2018.0042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211370PMC
November 2018
6 Reads