988 results match your criteria Metabolic Syndrome and Related Disorders [Journal]


Association Between Thyroid Nodules and Volume and Metabolic Syndrome in an Iodine-Adequate Area: A Large Community-Based Population Study.

Metab Syndr Relat Disord 2019 Feb 11. Epub 2019 Feb 11.

1 Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Background: Given its high incidence, thyroid nodule (TN) warrants public attention. Thyroid volume (TV) has also been associated with multiple factors, such as iodine deficiency and supply and body mass index. It is well known that metabolic syndrome (MetS) comprises many metabolic disturbances, with insulin resistance being its major component. Read More

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http://dx.doi.org/10.1089/met.2018.0094DOI Listing
February 2019

Comparison of Body Mass Index Percentiles to Detect Metabolic Syndrome Using the Korean, United States Centers for Disease Control and Prevention, and World Health Organization References in Korean Children Aged 10-16 Years.

Authors:
Kayoung Lee

Metab Syndr Relat Disord 2019 Feb 11. Epub 2019 Feb 11.

Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.

Background: Few studies have compared the local and international body mass index (BMI) reference sets for their relationship with metabolic syndrome (MetS) in children. This study aimed to compare the BMI percentiles using Korean, United States Centers for Disease Control and Prevention (US-CDC), and World Health Organization (WHO) charts for their ability to detect MetS in Korean children and examine their associations with the severity of MetS.

Methods: Among 3094 children (1653 boys, age: 10-16 years) from the Korean National Health and Examination Survey 2011-2016, age and sex-specific BMI percentiles using the three charts (Korean, US-CDC, and WHO charts) were determined. Read More

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http://dx.doi.org/10.1089/met.2018.0126DOI Listing
February 2019
1 Read

Changes in Cardiovascular Disease Risk Factors with Unintentional Versus Intentional Weight Loss: The Coronary Artery Risk Development in Young Adults Study.

Metab Syndr Relat Disord 2019 Feb 7. Epub 2019 Feb 7.

1 Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: It is well known that total and intentional weight loss (IWL) are associated with reductions in cardiovascular disease (CVD) risk factors, however, associations with unintentional weight loss (UWL) have not been studied.

Methods: We examined annual changes in blood pressure and lipids associated with UWL versus IWL in 576 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study who had lost weight over one of two time intervals (i.e. Read More

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http://dx.doi.org/10.1089/met.2018.0114DOI Listing
February 2019

The Effect of Proton Pump Inhibitors on Glycemic Control in Patients with Type 2 Diabetes.

Metab Syndr Relat Disord 2019 Feb 7. Epub 2019 Feb 7.

2 Medical Service, VA Northern California Health Care System, Martinez, California.

Background: Type 2 diabetes patients have decreased pancreatic beta cell mass with a decline in beta cell function. Gastrin has increased beta cell proliferation in vitro and in animal studies. High gastric acid levels inhibit gastrin secretion. Read More

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http://dx.doi.org/10.1089/met.2018.0138DOI Listing
February 2019
1 Read

The Role of Glucagon-Like Peptide-1 in Energy Homeostasis.

Metab Syndr Relat Disord 2019 Feb 5. Epub 2019 Feb 5.

3 The Knight Cardiovascular Institute, Mailcode MDYMI, Oregon Health and Science University, Portland, Oregon.

Energy homeostasis is coordinated by bidirectional communication pathways between the brain and peripheral organs, including adipose tissue, muscle, the pancreas, liver, and gut. Disruption of the integrated chemical, hormonal, and neuronal signals that constitute the gut-brain axis significantly contributes to disorders of metabolism and body weight. Initial studies of glucagon-like peptide-1 (GLP-1), a gut hormone released in response to the ingestion of nutrients, focused on its incretin actions to improve postprandial glucose homeostasis by enhancing meal-induced insulin secretion. Read More

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http://dx.doi.org/10.1089/met.2018.0088DOI Listing
February 2019

Age, Sex, and Cardiovascular Risk Attributable to Lipoprotein Cholesterol Among Chinese Individuals with Coronary Artery Disease: A Case-Control Study.

Metab Syndr Relat Disord 2019 Feb 5. Epub 2019 Feb 5.

1 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China.

Aim: To understand age- and gender-related differences and secular trends in coronary artery disease (CAD) lipid profiles and the characteristic of dyslipidemia in western China.

Methods: An age-matched case-control study, including 2400 patients and 1200 controls was performed. All blood lipid tests evaluated from January 2012 to January 2015 at First Affiliated Hospital of Xinjiang Medical University were analyzed. Read More

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http://dx.doi.org/10.1089/met.2018.0067DOI Listing
February 2019

Even Short-Term Telmisartan Treatment Ameliorated Insulin Resistance But Had No Influence on Serum Adiponectin and Tumor Necrosis Factor-Alpha Levels in Hypertensive Patients with Metabolic Syndrome.

Metab Syndr Relat Disord 2019 Jan 28. Epub 2019 Jan 28.

4 Department of Endocrinology and Metabolism, Medical Faculty, Uludag University, Bursa, Turkey.

Background: We investigated the effect of short-term telmisartan usage in addition to lifestyle changes such as diet and exercise on insulin resistance, lipid metabolism, and serum adiponectin and tumor necrosis factor-alpha (TNF-α) levels in hypertensive patients with metabolic syndrome (MetS).

Methods: A total of 36 hypertensive patients with MetS were randomized to telmisartan and control groups in an open-labeled prospective study.

Results: There were significant decreases in anthropometric variables of patients according to baseline measurements in both groups at the end of the study. Read More

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http://dx.doi.org/10.1089/met.2018.0129DOI Listing
January 2019

Salt, Hypertension, and the Lens.

Metab Syndr Relat Disord 2019 Jan 22. Epub 2019 Jan 22.

2 Urfa Education and Training Hospital, University of Health Sciences, Urfa, Turkey.

Background: Salt is important in the pathogenesis of hypertension (HT). Salt-sensitive hypertension (SSH) accounts for about half of all HT cases. In SSH, sodium/potassium adenosine triphosphatase (Na/K-ATPase) activity is impaired. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0117
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http://dx.doi.org/10.1089/met.2018.0117DOI Listing
January 2019
4 Reads

The Relationship Between Housing Types and Metabolic and Weight Phenotypes: A Nationwide Survey.

Authors:
Kayoung Lee

Metab Syndr Relat Disord 2019 Jan 22. Epub 2019 Jan 22.

Department of Family Medicine, College of Medicine, Busan Paik Hospital, Inje University, Busan, Republic of Korea.

Background: Compared to studies evaluating the effect of environmental factors on weight and health, relationships between housing types and health conditions are understudied. This study aimed to assess the relationship between housing types and metabolic and weight phenotypes using data from the 2014 to 2015 Korea National Health and Nutrition Examination Survey.

Methods: A total of 9586 Korean adults (4128 men and 5458 women; mean age, 50. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0109
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http://dx.doi.org/10.1089/met.2018.0109DOI Listing
January 2019
3 Reads

Metabolic Health in Severely Obese Subjects: A Descriptive Study.

Metab Syndr Relat Disord 2019 Jan 16. Epub 2019 Jan 16.

3 Steno Diabetes Center Copenhagen, Gentofte, Denmark.

Background: The prevalence of metabolically healthy obese (MHO) subjects among morbidly obese subjects is poorly described.

Aim: To describe the prevalence of metabolically healthy subjects in a group of morbidly obese referred for bariatric surgery.

Methods: Descriptive cross-sectional study, 1209 subjects (825 women/384 men) mean body mass index (BMI) of 45. Read More

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http://dx.doi.org/10.1089/met.2018.0083DOI Listing
January 2019

Determinants of Changes in Metabolic Syndrome Components in a 12-Year Cohort of Iranian Adults.

Metab Syndr Relat Disord 2019 Jan 8. Epub 2019 Jan 8.

1 Public Health, School of Medicine and Menzies Health Institute Queensland, Griffith University, Southport, Australia.

Background: The prevalence of metabolic syndrome (MetS) and its components have been increasing globally; therefore, there is a need for better understanding of MetS components and their risk factors, as well as their development and changes over time. This study was designed to identify the determinants of the changes in the components of MetS in a cohort of Iranian adults from 2001 to 2013.

Methods: A total of 6504 adults, ≥35 years of age, were recruited from central Iran in 2001and were followed up in an ongoing longitudinal population-based study for 12 years. Read More

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http://dx.doi.org/10.1089/met.2018.0026DOI Listing
January 2019

Assessment of Arterial Stiffness in Metabolic Syndrome Related to Insulin Resistance in Apparently Healthy Men.

Metab Syndr Relat Disord 2019 Jan 8. Epub 2019 Jan 8.

3 Division of Metabolic Diseases, Epidemiology Research Center, AJA University of Medical Science, Tehran, Iran.

Background: Assessment of subclinical atherosclerosis in metabolic syndrome is one of the global health targets' priorities. This study aimed to evaluate the subclinical atherosclerosis in metabolic syndrome related to insulin resistance in healthy and physically active men.

Methods: A consecutive group of 68 healthy men, 30-55 years of age, was studied. Read More

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http://dx.doi.org/10.1089/met.2018.0090DOI Listing
January 2019
2 Reads
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The Relationship Between Cardiorespiratory Fitness and Arterial Stiffness in Middle-Aged Men with Abdominal Obesity.

Metab Syndr Relat Disord 2019 Jan 8. Epub 2019 Jan 8.

Department of Sports Medicine Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Abdominal obesity increases rapidly after middle age in Korean men, and there is an associated trend toward increasing levels of cardiovascular disease (CVD). The purpose of this study was to examine the effect of cardiorespiratory fitness (CRF) on arterial stiffness in men with abdominal obesity.

Methods: A total of 387 middle-aged men (ages 42-59 years) with abdominal obesity participated in this cross-sectional study. Read More

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http://dx.doi.org/10.1089/met.2018.0068DOI Listing
January 2019
2 Reads

Prevalence of Metabolic Syndrome and Its Relation to Physical Activity and Nutrition in Azerbaijan.

Metab Syndr Relat Disord 2019 Jan 8. Epub 2019 Jan 8.

1 Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey.

Background: Metabolic syndrome (MetS) is an important public health concern associated with an increased risk for cardiovascular disease and type 2 diabetes. Despite its global significance, the prevalence of MetS in Azerbaijan is unknown. The purpose of this study was to examine the prevalence of MetS and its relation to physical activity (PA) and nutrition in a representative sample of Azerbaijani adults. Read More

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http://dx.doi.org/10.1089/met.2018.0096DOI Listing
January 2019

Pubertal Status and Gonadal Functions in Obese Boys with Fatty Liver.

Metab Syndr Relat Disord 2019 Jan 7. Epub 2019 Jan 7.

1 Department of Biochemistry, University of Health Sciences , Konya Training and Research Hospital, Konya, Turkey .

Background: In adult studies, obese subjects with nonalcoholic fatty liver disease (NAFLD) have been shown to have poor sperm quality, and lower testosterone and luteinizing hormone levels. The aim of this study was to investigate the pubertal status and gonadal functions in obese boys with NAFLD.

Materials And Methods: The study included 119 obese and 78 nonobese age-matched adolescents. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0050
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http://dx.doi.org/10.1089/met.2018.0050DOI Listing
January 2019
7 Reads

Serum Uric Acid to Creatinine Ratio Independently Predicts Incident Metabolic Syndrome Among Community-Dwelling Persons.

Metab Syndr Relat Disord 2019 Jan 7. Epub 2019 Jan 7.

1 Department of Community Medicine, Ehime University Graduate School of Medicine , Toon, Japan .

Background: Metabolic syndrome (MetS) is related to the increased risk of major cardiovascular disease. The link between high serum uric acid (SUA) and creatinine (Cr) levels is causally related to MetS and its components. However, whether renal function-normalized SUA [i. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0055
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http://dx.doi.org/10.1089/met.2018.0055DOI Listing
January 2019
3 Reads

Effects of the Relative Distribution of Body Mass Index on the Incidence of Hypertension and Diabetes Mellitus, Using the Korean Obesity Index.

Metab Syndr Relat Disord 2018 Dec 13. Epub 2018 Dec 13.

Big Data Steering Department, National Health Insurance Service , Wonju, Korea.

Background: The Korean Obesity Index, which contains standard reference data (SRD) of obesity, was established in 2016 and revised in 2017 based on national health screening data to provide the distribution of the body mass index (BMI) of the whole population of Korea as a reference. This study aimed to investigate the effect of the SRD of obesity on the incidence of hypertension (HTN) and diabetes mellitus (DM).

Methods: The percentile of BMI was calculated for each of the 864 subgroups by defined by gender, region, and age group according to the groupings in the SRD. Read More

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http://dx.doi.org/10.1089/met.2018.0104DOI Listing
December 2018

Prevalence of Optimal Metabolic Health in American Adults: National Health and Nutrition Examination Survey 2009-2016.

Metab Syndr Relat Disord 2019 Feb 27;17(1):46-52. Epub 2018 Nov 27.

1 Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: Several guidelines for cardiometabolic risk factor identification and management have been released in recent years, but there are no estimates of current prevalence of metabolic health among adults in the United States. We estimated the proportion of American adults with optimal cardiometabolic health, using different guidelines.

Methods: Data from the National Health and Nutrition Examination Survey 2009-2016 were analyzed (n = 8721). Read More

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http://dx.doi.org/10.1089/met.2018.0105DOI Listing
February 2019

Brain-Derived Neurotrophic Factor and Its Associations with Metabolism and Physical Activity in a Latino Sample.

Metab Syndr Relat Disord 2018 Nov 10. Epub 2018 Nov 10.

2 Mayo Clinic Translational Neuroscience and Aging Program, Mayo Clinic , Scottsdale, Arizona.

Background: Brain-derived neurotrophic factor (BDNF) is associated with body weight and other health conditions but remains understudied in the Latino population. The aim of this study was to examine the associations of BDNF serum levels with body mass index (BMI), physical activity, and the rs6265 nonconservative polymorphism among 349 Latinos aged ≥18 years enrolled in the Arizona Insulin Resistance Registry.

Materials And Methods: Data on physical activity were acquired using a self-reported questionnaire. Read More

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http://dx.doi.org/10.1089/met.2018.0028DOI Listing
November 2018

Prediction of Insulin Resistance with Anthropometric and Clinical Laboratory Measures in Nondiabetic Teenagers.

Metab Syndr Relat Disord 2019 Feb 3;17(1):37-45. Epub 2018 Nov 3.

3 Department of Research, Womack Army Medical Center, Fort Bragg, North Carolina.

Background: Adolescent obesity is an important risk factor for cardiovascular disease in part due to its relationship to type 2 diabetes. Therefore, screening for type 2 diabetes is recommended. However, since insulin resistance (IR) is an early precursor of diabetes, it would be beneficial if IR predictors from routine assessments could identify those at greatest metabolic risk before diabetes has developed. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0072
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http://dx.doi.org/10.1089/met.2018.0072DOI Listing
February 2019
5 Reads

A Global MicroRNA Profile in Fanconi Anemia: A Pilot Study.

Metab Syndr Relat Disord 2019 Feb 30;17(1):53-59. Epub 2018 Oct 30.

1 Mutagenesis and Preventive Oncology, Ospedale Policlinico San Martino, Genova, Italy.

Purpose: Fanconi anemia (FA) is a complex tumor-prone disease defined by an entangled genotype and phenotype. Despite enormous efforts in the last 20 years, a comprehensive and integrated view of the disease is still missing. The aim of this pilot study was to establish whether a global microRNA (miRNA) analysis approach could be helpful in defining aspects in FA phenotype, which might deserve future attention with the perspective to develop miRNA-based therapies. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0085
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http://dx.doi.org/10.1089/met.2018.0085DOI Listing
February 2019
12 Reads

The Association Between Metabolic Syndrome and Serum Concentrations of Micronutrients, Inflammation, and Oxidative Stress Outside of the Clinical Reference Ranges: A Cross-Sectional Study.

Metab Syndr Relat Disord 2019 Feb 27;17(1):29-36. Epub 2018 Oct 27.

1 School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.

Background: Clinical reference ranges are often used to assess nutritional status, but whether having lower or higher than the current clinical reference range for micronutrients, inflammation, and oxidative stress is related to metabolic syndrome (MetS) is not known. Our objectives are to estimate the odds of having MetS outside of established clinical references, and to identify any effect modifications by sex have for these relationships.

Methods: Data from the 2005 to 2006 National Health and Nutrition Examination Survey were used (≥20 years; N = 2049) with MetS defined utilizing the harmonized criteria from the Joint Interim Statement. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0080
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http://dx.doi.org/10.1089/met.2018.0080DOI Listing
February 2019
7 Reads

Plasma Growth Arrest-Specific 6 Protein and Genetic Variations in the GAS6 Gene in Patients with Metabolic Syndrome.

Metab Syndr Relat Disord 2019 Feb 20;17(1):22-28. Epub 2018 Oct 20.

1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background: Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted by immune cells, endothelial cells, vascular smooth muscle cells, and adipocytes. Recent studies indicate that Gas6 and receptors of the TAM (Tyro3, Axl, and Mer) family may be involved in the pathogenesis of obesity, systemic inflammation, and insulin resistance. The aim of this study was to investigate the association between plasma Gas6 protein and the c. Read More

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http://dx.doi.org/10.1089/met.2017.0143DOI Listing
February 2019

Growth Hormone Deficiency and Nonalcoholic Fatty Liver Disease with Insights from Humans and Animals: Pediatric Implications.

Authors:
Rohan K Henry

Metab Syndr Relat Disord 2018 Oct 20. Epub 2018 Oct 20.

Division of Endocrinology, Department of Pediatrics, Nationwide Children's Hospital/The Ohio State University College of Medicine , Columbus, Ohio.

In addition to its growth promoting role, growth hormone (GH) has a significant effect on intermediary metabolism in the well state. Despite the latter fact, pediatric practitioners are usually focused on the growth promoting aspects of GH as opposed to those metabolic. In recent years various animal and human studies (in adults mainly) and clinical reports in children have repeatedly shown the association of GH deficiency (GHD) and fatty liver disease. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0056
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http://dx.doi.org/10.1089/met.2018.0056DOI Listing
October 2018
14 Reads

Acute Physical Effort Increases Sympathovagal Balance Responses to Autonomic Stimulation in Metabolic Syndrome.

Metab Syndr Relat Disord 2019 Feb 17;17(1):67-74. Epub 2018 Oct 17.

3 Centre of Human and Applied Physiological Sciences, Department of Physiology, School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

Background: There is little evidence of how metabolic syndrome (MS) affects sympathovagal balance responses to acute physical effort (APE) and autonomic stimulation (AS). This study aimed to evaluate the heart rate variability (HRV) responses to the combined APE and AS challenges.

Methods: Fourteen subjects (8 men; 49. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0065
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http://dx.doi.org/10.1089/met.2018.0065DOI Listing
February 2019
4 Reads

Determinants of Fasting Hyperglucagonemia in Patients with Type 2 Diabetes and Nondiabetic Control Subjects.

Metab Syndr Relat Disord 2018 Dec 16;16(10):530-536. Epub 2018 Oct 16.

1 Clinical Metabolic Physiology, Steno Diabetes Center Copenhagen, Gentofte Hospital, Hellerup, Denmark .

Background: Fasting hyperglucagonemia can be detrimental to glucose metabolism in patients with type 2 diabetes (T2D) and may contribute to metabolic disturbances in obese and/or prediabetic subjects. However, the mechanisms underlying fasting hyperglucagonemia remain elusive.

Methods: We evaluated the interrelationship between fasting hyperglucagonemia and demographic and biochemical parameters in 106 patients with T2D (31% female, age: 57 ± 9 years [mean ± standard deviation; body mass index (BMI): 30. Read More

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http://dx.doi.org/10.1089/met.2018.0066DOI Listing
December 2018
1 Read

Diabetes Is Associated with Cognitive Decline in Middle-Aged Patients.

Metab Syndr Relat Disord 2018 Oct 11. Epub 2018 Oct 11.

1 Escuela de Medicina, Universidad Catolica Santiago de Guayaquil , Guayaquil, Ecuador .

Background: Diabetes is a major contributor to dementia in the elderly. Identifying mild cognitive decline in younger individuals with diabetes could aid in preventing the progression of the disease. The aim of our study is to compare whether patients with diabetes experience greater cognitive decline than those without diabetes. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0014
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http://dx.doi.org/10.1089/met.2018.0014DOI Listing
October 2018
14 Reads

Hypertensive Waist and Lipid Accumulation Product as Predictors of Metabolic Syndrome.

Metab Syndr Relat Disord 2018 Dec 6;16(10):505-506. Epub 2018 Oct 6.

1 Department of Diabetes and Nutrition, Iuliu Hatieganu University of Medicine and Pharmacy , Cluj-Napoca, Romania .

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https://www.liebertpub.com/doi/10.1089/met.2018.0098
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http://dx.doi.org/10.1089/met.2018.0098DOI Listing
December 2018
2 Reads

Relationship Between Obesity and Lumbar Spine Degeneration: A Cross-Sectional Study from the Fifth Korean National Health and Nutrition Examination Survey, 2010-2012.

Metab Syndr Relat Disord 2019 Feb 6;17(1):60-66. Epub 2018 Oct 6.

2 Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background: Although several studies have shown that obesity affects low back pain (LBP), the relationship between degenerative lumbar spine (LSD) and obesity has not been fully investigated. This study evaluated whether obesity is independently associated with LSD in the general population.

Methods: This cross-sectional study used public data from the Fifth Korean National Health and Nutrition Examination Survey (2010-2012). Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0051
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http://dx.doi.org/10.1089/met.2018.0051DOI Listing
February 2019
3 Reads

Objectively Measured Physical Activity, Sedentary Behavior, and Metabolic Syndrome in Adults: Systematic Review of Observational Evidence.

Metab Syndr Relat Disord 2019 Feb 29;17(1):1-21. Epub 2018 Sep 29.

School of Nutrition and Dietetics, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Kuala Nerus, Terengganu, Malaysia.

Objective measurement of physical activity (PA) and sedentary behavior (SB) associated with metabolic syndrome (MetS) has gained more attention among researchers in recent years. Although almost similar trends of results have been reported worldwide, they were not always statistically significant. This systematic review summarizes the evidence of observational studies reporting the associations between objectively measured PA, SB, and MetS in adults. Read More

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http://dx.doi.org/10.1089/met.2018.0032DOI Listing
February 2019
10 Reads

Gender as an Independent Risk Factor for the Components of Metabolic Syndrome Among Individuals Within the Normal Range of Body Mass Index.

Metab Syndr Relat Disord 2018 Sep 11. Epub 2018 Sep 11.

1 Department of Medicine F - Recanati and Clinical Pharmacology Unit, Rabin Medical Center (Beilinson Hospital) , Petah Tikva, Israel .

Background: Overweight and obesity are more common in men than in women. This explains the higher prevalence of risk factors for metabolic syndrome (MetS) found in men. We aimed to assess whether gender, per se, might be an independent risk factor for the components of MetS in a large cohort of subjects within the normal range of body mass index (BMI). Read More

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http://dx.doi.org/10.1089/met.2018.0071DOI Listing
September 2018

Predictive Value of Lipid Accumulation Product, Fatty Liver Index, Visceral Adiposity Index for Metabolic Syndrome According to Menopausal Status.

Metab Syndr Relat Disord 2018 Nov 5;16(9):477-482. Epub 2018 Sep 5.

Department of Obstetrics and Gynecology, School of Medicine, Medical Research Institute, Pusan National University Hospital , Busan, Korea.

Background: The aim of this study is to investigate the value of clinical indicators of metabolic syndrome according to menopausal status in healthy Korean women.

Methods: The study included 3936 female patients who were managed at Pusan National University Hospital Health Promotion Center from 2008 to 2014. Each patient completed self-report questionnaires and underwent personal interviews with a healthcare provider to assess their past medical history such as any previous disease, medication and/or menstrual histories along with the measurement of her current body size. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0019
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http://dx.doi.org/10.1089/met.2018.0019DOI Listing
November 2018
10 Reads

Determining Factors of Arterial Stiffness in Subjects with Metabolic Syndrome.

Metab Syndr Relat Disord 2018 Nov 5;16(9):490-496. Epub 2018 Sep 5.

6 Clinical Center of Diabetes, Nutrition, Metabolic Diseases, "Iuliu Haţieganu" University of Medicine and Pharmacy , Cluj-Napoca, Romania .

Background: Metabolic syndrome (MS) is a clustering entity characterized by obesity, hypertension, hyperglycemia, dyslipidemia, and insulin resistance. Early detection of atherosclerosis is important in patients with MS because cardiovascular diseases are the main cause of mortality in these patients.

Methods: We aimed to investigate the factors influencing arterial stiffness, pulse wave velocity, and the augmentation index, respectively, in 150 subjects with MS (94 women and 56 men; mean age 60. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0057
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http://dx.doi.org/10.1089/met.2018.0057DOI Listing
November 2018
8 Reads

Can the Plasma Concentration Ratio of Triglyceride/High-Density Lipoprotein Cholesterol Identify Individuals at High Risk of Cardiovascular Disease During 40-Year Follow-Up?

Metab Syndr Relat Disord 2018 Oct 5;16(8):433-439. Epub 2018 Sep 5.

2 Department of Medicine, Stanford University , Stanford, California.

Background: The plasma concentration ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) is a simple way to estimate insulin resistance. We aimed to evaluate the TG/HDL-C ratio as a simple clinical way to identify apparently healthy individuals with insulin resistance and enhanced risk of future cardiovascular disease (CVD).

Methods: One thousand seven hundred twenty men, aged 50 years, free from diabetes and CVD when evaluated at baseline in 1970-1974 were followed for 40 years regarding incident CVD (myocardial infarction and/or ischemic stroke, n = 576). Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0058
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http://dx.doi.org/10.1089/met.2018.0058DOI Listing
October 2018
6 Reads

Detection of Glycemia and Osmolarity Changes Using Eye Examinations.

Metab Syndr Relat Disord 2018 Sep 5. Epub 2018 Sep 5.

4 Department of Ophthalmology, Keçiören Education and Training Hospital, University of Health Sciences, Ankara, Turkey .

Background: Glycated hemoglobin (HbA1c) is an index of the average blood glucose level over the preceding 2-3 months. In experimental studies, the lens responded to changes in osmolarity by forming vacuoles. By observing the vacuoles of the lens during eye examination, can we detect changes in osmolarity and glycemia over the last 6 months through HbA1c levels?

Methods: In total, 400 patients (mean age, 67. Read More

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http://dx.doi.org/10.1089/met.2018.0076DOI Listing
September 2018
3 Reads

Obesity, Visceral Fat, and Hypertension-Related Complications.

Metab Syndr Relat Disord 2018 Sep 5. Epub 2018 Sep 5.

1 Department of Cardiology, School of Health Sciences, Medical University of Silesia , Katowice, Poland .

Background: Hypertension and obesity are very common and complex cardiovascular (CV) risk factors. Our aim was to provide a comprehensive assessment of associations between visceral fat depots and vascular or cardiac complications of hypertension.

Methods: All the consecutive patients (age: 45-80 years old) scheduled for elective coronary angiography in the Department of Cardiology were screened, and 400 patients were included into the study group. Read More

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http://dx.doi.org/10.1089/met.2018.0062DOI Listing
September 2018
1 Read

High Body Mass Index Masks Body Composition Differences in Physically Active Versus Sedentary Participants.

Metab Syndr Relat Disord 2018 Nov 21;16(9):483-489. Epub 2018 Aug 21.

1 Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota , Minnesota, Minneapolis.

Background: Despite the benefits of aerobic exercise on body composition, runners with high body mass index (BMI) remain understudied. We examined body composition differences between sedentary insulin-resistant [obese insulin-resistant sedentary (OS-IR)], sedentary insulin-sensitive [obese insulin-sensitive sedentary (OS-IS)], and trained [obese trained (OT)] individuals with high BMI (≥25 kg/m). We hypothesized that after matching for high BMI, OT individuals would have less fat mass (absolute and relative) and greater lean mass than OS-IR or OS-IS individuals. Read More

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http://www.liebertpub.com/doi/10.1089/met.2018.0042
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http://dx.doi.org/10.1089/met.2018.0042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211370PMC
November 2018
6 Reads

Relationship Between Handgrip Strength and Nonalcoholic Fatty Liver Disease: Nationwide Surveys.

Authors:
Kayoung Lee

Metab Syndr Relat Disord 2018 Nov 21;16(9):497-503. Epub 2018 Aug 21.

Department of Family Medicine, Busan Paik Hospital, College of Medicine, Inje University , Busan, Republic of Korea.

Background: The association of handgrip strength with nonalcoholic fatty liver disease (NAFLD) has not been studied yet. This study investigated the relationship between handgrip strength and NAFLD in South Korean adults.

Methods: Referring to the Korea National Health and Nutrition Examination Survey 2014 and 2015 database, South Korean adults (n = 8001, women: 55. Read More

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http://dx.doi.org/10.1089/met.2018.0077DOI Listing
November 2018
1 Read

Effects of Freeze-Dried Grape Powder on High-Density Lipoprotein Function in Adults with Metabolic Syndrome: A Randomized Controlled Pilot Study.

Metab Syndr Relat Disord 2018 Nov 21;16(9):464-469. Epub 2018 Aug 21.

Department of Nutritional Sciences, University of Connecticut , Storrs, Connecticut.

Background: High-density lipoprotein (HDL) particles are protective against atherosclerosis. However, HDL function is impaired in metabolic syndrome (MetS) due to low-grade inflammation and dyslipidemia. Foods containing polyphenols, such as grapes, may prevent HDL dysfunction via antioxidant or anti-inflammatory effects. Read More

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http://dx.doi.org/10.1089/met.2018.0052DOI Listing
November 2018
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Mixed Meal and Intravenous L-Arginine Tests Both Stimulate Incretin Release Across Glucose Tolerance in Man: Lack of Correlation with β Cell Function.

Metab Syndr Relat Disord 2018 Oct 17;16(8):406-415. Epub 2018 Aug 17.

12 ROI BioPharma Consulting , East Lyme, Connecticut.

Background: The aims of this study were to 1. define the responses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), glucagon, and peptide YY (PYY) to an oral meal and to intravenous L-arginine; and 2. examine correlation of enteroendocrine hormones with insulin secretion. Read More

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http://dx.doi.org/10.1089/met.2018.0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167614PMC
October 2018
16 Reads

The Metabolic Syndrome and Health Behaviors in School Children Aged 13-16 Years in Ubon Ratchathani: UMeSIA Project.

Metab Syndr Relat Disord 2018 Oct 14;16(8):425-432. Epub 2018 Aug 14.

2 Ubon Ratchathani Provincial Public Health Office , Ubon Ratchathani, Thailand .

Background: Although metabolic syndrome (MetS) has become a significant public health problem worldwide, little evidence exists to describe the prevalence of MetS in school children using MetS different classifications, and its association with health-related behaviors.

Methods: Using data on 393 children and adolescents aged 13-16 years participating in the Ubon Ratchathani Metabolic Syndrome in Adolescent (UMeSIA) Project, the prevalence of MetS was determined using the International Diabetes Federation (IDF) 2007 definition and other three classifications reported in the previous literature. The prevalence of the MetS was compared across sex, a family history of diabetes, type of schools, and health behaviors using chi-square test. Read More

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http://dx.doi.org/10.1089/met.2017.0150DOI Listing
October 2018

Relationship Between Platelet Count and Insulin Resistance in Korean Adolescents: A Nationwide Population-Based Study.

Metab Syndr Relat Disord 2018 Nov 10;16(9):470-476. Epub 2018 Aug 10.

1 Department of Family Medicine, Gangnam Severance Hospital , Seoul, Republic of Korea.

Background: To examine the relationship between platelet count and insulin resistance, as measured by a homeostasis model assessment of insulin resistance (HOMA-IR), in a nationally representative sample of Korean adolescents.

Methods: The study population comprised 1133 participants (636 male and 497 female participants) aged 12-18 years selected from the 2008-2010 Korea National Health and Nutrition Examination Survey. Insulin resistance was defined as a HOMA-IR value greater than the 85th percentile. Read More

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http://www.liebertpub.com/doi/10.1089/met.2018.0016
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http://dx.doi.org/10.1089/met.2018.0016DOI Listing
November 2018
11 Reads

Are Risk Factors for Coronary Artery Disease Different in Persons With and Without Obesity?

Metab Syndr Relat Disord 2018 Oct 8;16(8):440-445. Epub 2018 Aug 8.

4 Department of Nutrition and Food Technology, Faculty of Agriculture, University of Jordan , Amman, Jordan .

Background: Although obesity is an independent risk factor for coronary artery disease (CAD), observational studies have found that persons with obesity have a better prognosis in established CAD compared with those with a normal body weight, suggesting that the underlying risk factors might differ between the two groups. In this study, we studied risk factors for CAD in persons with and without obesity in a Middle Eastern setting where obesity is endemic.

Methods: Five hundred and fifty-six patients referred for elective coronary catheterization at Prince Hamza Hospital, Amman were included in a cross-sectional study. Read More

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http://dx.doi.org/10.1089/met.2017.0152DOI Listing
October 2018
17 Reads

Prevalence of Metabolic Syndrome in Mexico: A Systematic Review and Meta-Analysis.

Metab Syndr Relat Disord 2018 Oct 31;16(8):395-405. Epub 2018 Jul 31.

2 Center for Research and Advanced Studies (CINVESTAV-IPN) , Mérida, Yucatan, Mexico .

Background: Metabolic syndrome (MetS) is closely linked with type 2 diabetes mellitus (T2DM) and cardiovascular diseases. The T2DM is one of the major causes of mortality and public health concern in Mexico. Some studies reported MetS prevalence in different regions from Mexico. Read More

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http://dx.doi.org/10.1089/met.2017.0157DOI Listing
October 2018
17 Reads

Association of Plasma Pentraxin-3 Levels with Retinopathy and Systemic Factors in Diabetic Patients.

Metab Syndr Relat Disord 2018 Sep 23;16(7):358-365. Epub 2018 Jul 23.

5 Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University , Istanbul, Turkey .

Background: Diabetic retinopathy (DR) is mainly caused by metabolic factors, vascular inflammation, and endothelial dysfunction. We aimed to evaluate the relationship of DR with inflammatory and biochemical alterations in type 2 diabetics.

Methods: A total of 89 diabetic patients with retinopathy [(DR (+) (n = 30)], without retinopathy [(DR (-) (n = 32)], and 27 control subjects were involved in the study. Read More

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http://dx.doi.org/10.1089/met.2018.0023DOI Listing
September 2018
15 Reads

Combination Therapies for Obesity.

Metab Syndr Relat Disord 2018 Oct 11;16(8):390-394. Epub 2018 Jul 11.

Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic , Rochester, Minnesota.

The objective of this review is to examine advances in the development of combination therapies for the treatment of obesity beyond diet or lifestyle interventions. Experimental combination pharmacotherapies include combinations of pramlintide and phentermine as well as amylin and bupropion-naltrexone. Incretin and pancreatic hormones generally inhibit upper gastrointestinal motor functions, and combinations showing efficacy in obesity are coadministration of glucagon-like peptide-1 (GLP-1) with glucagon, a unimolecular dual incretin of PEGylated GLP-1/GIP coagonist, the combination of GLP-1 and PYY, and, in proof of concept studies, combined infusions of GLP-1, peptide YY, and oxyntomodulin. Read More

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http://dx.doi.org/10.1089/met.2018.0075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167613PMC
October 2018
6 Reads

What Can Diabetes-Associated Genetic Variation in TCF7L2 Teach Us About the Pathogenesis of Type 2 Diabetes?

Metab Syndr Relat Disord 2018 Oct 11;16(8):383-389. Epub 2018 Jul 11.

Endocrine Research Unit, Department of Endocrinology, Diabetes and Nutrition, Mayo Clinic College of Medicine , Rochester, Minnesota.

Type 2 diabetes mellitus (T2DM) is a polygenic metabolic disorder characterized by hyperglycemia occurring as a result of impaired insulin secretion and/or insulin resistance. Among the various genetic factors associated with T2DM, a common genetic variant within the transcription factor 7-like 2 locus (TCF7L2) confers the greatest genetic risk for development of the disease. However, the mechanism(s) by which TCF7L2 predisposes to diabetes remain uncertain. Read More

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http://dx.doi.org/10.1089/met.2018.0024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167616PMC
October 2018
7 Reads

Association Between Serum CK-18 Levels and the Degree of Liver Damage in Fructose-Induced Metabolic Syndrome.

Metab Syndr Relat Disord 2018 Sep 10;16(7):350-357. Epub 2018 Jul 10.

6 Department of Biochemistry, Molecular Medicine and Nutrigenomics, Faculty of Pharmacy, Medical University of Varna , Varna, Bulgaria .

Background: The pathogenesis of nonalcoholic fatty liver disease as a component of metabolic syndrome (MetS) involves the activation of apoptosis in steatotic hepatocytes. Caspase-generated fragments such as cytokeratin-18 (CK-18) in patients with various hepatic impairments are investigated as markers for diagnosis and assessment of disease severity. The goal of the study was to capture early biomarkers of apoptosis and elucidate their role in assessing the presence and extent of hepatic damage in a MetS model. Read More

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http://dx.doi.org/10.1089/met.2017.0162DOI Listing
September 2018
8 Reads
1.916 Impact Factor

Educational Disparities in Risk for Metabolic Syndrome.

Metab Syndr Relat Disord 2018 Oct 5;16(8):416-424. Epub 2018 Jul 5.

1 Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul, South Korea .

Background: The objective of this study was to evaluate the relationship between educational level as a surrogate marker of socioeconomic status and the risk of developing metabolic syndrome (MetS).

Methods: Study subjects were 1915 Korean adults (1193 women and 722 men) who participated in a cohort study. Educational level was categorized into two groups: (1) high education (more than 12 years of education), and (2) low education (less than 12 years of education). Read More

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http://dx.doi.org/10.1089/met.2017.0170DOI Listing
October 2018
6 Reads

Should Waist Circumference Cutoffs in the Context of Cardiometabolic Risk Factor Assessment be Specific to Sex, Age, and BMI?

Metab Syndr Relat Disord 2018 Sep 5;16(7):366-374. Epub 2018 Jul 5.

1 Faculty of Physical Activity Sciences, Department of Kinanthropology, University of Sherbrooke , Sherbrooke, Quebec, Canada .

Objective: A sex-specific standard waist circumference (WC) is widely used to determine cardiometabolic risk across ages even though aging impacts the link between fat distribution and cardiometabolic risk. The objective was to propose WC thresholds that better predict metabolic abnormalities according to sex, age, and body mass index (BMI) categories.

Methods: First, receiver operating characteristic analyses were performed to identify optimal age (20-49, 50-64, and 65-80 years) and BMI (normal weight, overweight, obese I, and obese II+) specific WC thresholds to correctly identify at-risk individuals, that is, presenting ≥2 cardiometabolic risk factors of metabolic syndrome (n = 23,482; NHANES 2007-2014). Read More

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http://dx.doi.org/10.1089/met.2017.0177DOI Listing
September 2018
13 Reads