74,443 results match your criteria Metabolic Syndrome


Relationships Between Biochemical Markers of Hyperandrogenism and Metabolic Parameters in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.

Horm Metab Res 2019 Jan 16;51(1):22-34. Epub 2019 Jan 16.

Endocrinology Unit, Department of Health Sciences and Mother and Child Care, University of Palermo, Palermo, Italy.

While several studies have documented an increased risk of metabolic disorders in patients with polycystic ovary syndrome (PCOS), associations between androgenic and metabolic parameters in these patients are unclear. We aimed to investigate the relationships between biochemical markers of hyperandrogenism (HA) and metabolic parameters in women with PCOS. In this systematic review and meta-analysis, a literature search was performed in the PubMed, Scopus, Google Scholar, ScienceDirect, and Web of Science from 2000 to 2018 for assessing androgenic and metabolic parameters in PCOS patients. Read More

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http://dx.doi.org/10.1055/a-0806-8281DOI Listing
January 2019

Diabetes and Metabolic Syndrome in Survivors of Childhood Cancer.

Horm Res Paediatr 2019 Jan 16:1-10. Epub 2019 Jan 16.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Endocrine complications, including diabetes and metabolic syndrome, are highly prevalent in childhood cancer survivors. These metabolic derangements may contribute to survivors' risk of excess cardiovascular morbidity and premature mortality. This review summarizes existing knowledge on risk of diabetes and metabolic syndrome among childhood cancer survivors, focusing specifically on known risk factors, potential mechanisms, and screening recommendations. Read More

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http://dx.doi.org/10.1159/000495698DOI Listing
January 2019

Metabolic Syndrome and Economic Strain Among Sexual Minority Young Adults.

LGBT Health 2019 Jan;6(1):1-8

1 Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Purpose: The study tested if sexual orientation is associated with metabolic syndrome (MetS) in young adulthood (ages 24-32), and if economic strain impacts associations.

Methods: Gender-stratified logistic regressions were fit among 11,575 young adults (1644 sexual minority [SM]) in Wave IV of The National Longitudinal Study of Adolescent to Adult Health.

Results: MetS was not associated with sexual orientation for either gender, yet economic strain was more prevalent among both SM males and females. Read More

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http://dx.doi.org/10.1089/lgbt.2018.0053DOI Listing
January 2019

Red meat consumption and metabolic syndrome in the Costa Rica Heart Study.

Eur J Nutr 2019 Jan 16. Epub 2019 Jan 16.

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.

Purpose: Several epidemiologic investigations have found associations between the consumption of red meat and the metabolic syndrome (MetS). Very few studies have looked at populations undergoing the nutrition transition with smaller levels of red meat consumption than those in Westernized countries. In this population-based cross-sectional study, we examined the association between red meat consumption and MetS in Costa Rican adults, a population with comparably lower consumption of red meat. Read More

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http://dx.doi.org/10.1007/s00394-019-01898-6DOI Listing
January 2019

Adipose Insulin Resistance in Normal-Weight Polycystic Ovary Syndrome Women.

J Clin Endocrinol Metab 2019 Jan 11. Epub 2019 Jan 11.

Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 (D.A.D, J.D.P., K.L.L., L.R.H., G.D.C.).

Context: Normal-weight polycystic ovary syndrome (PCOS) women may have adipose insulin resistance (adipose-IR).

Objective: To examine whether adipose-IR and subcutaneous (SC) abdominal adipose stem cell (ASC) gene expression are altered in normal-weight PCOS women and correlated with hyperandrogenemia and/or insulin resistance.

Design: Prospective cohort study. Read More

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http://dx.doi.org/10.1210/jc.2018-02086DOI Listing
January 2019

Adipocyte GR inhibits healthy adipose expansion through multiple mechanisms in Cushing's syndrome.

Endocrinology 2019 Jan 15. Epub 2019 Jan 15.

Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.

In Cushing's syndrome, excessive glucocorticoids lead to metabolic disturbances, such as insulin resistance, adipocyte hypertrophy and liver steatosis. In vitro experiments have highlighted the importance of adipocyte glucocorticoid receptor (Gr), but its metabolic roles in vivo have not been fully elucidated in Cushing's syndrome. In this study, using clinical samples from patients with Cushing's syndrome and adipocyte-specific Gr knockout mice (AGRKO), we investigated the roles of adipocyte GR and its clinical relevance in Cushing's syndrome. Read More

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http://dx.doi.org/10.1210/en.2018-01029DOI Listing
January 2019

Thyroid Dysfunction and Diabetes Mellitus : Two Closely Associated Disorders.

Endocr Rev 2019 Jan 14. Epub 2019 Jan 14.

R. Paul Robertson, M.D. Division of Endocrinology and Metabolism, Department of Medicine and Pharmacology, University of Washington, Seattle, WA, USA.

Thyroid dysfunction and diabetes mellitus are closely linked. Several studies have documented the increased prevalence of thyroid disorders in patients with diabetes mellitus and viceversa. This review critically discusses the different underlying mechanisms linking type 1 and 2 diabetes and thyroid dysfunction to demonstrate that the association of these two common disorders is unlikely a simple coincidence. Read More

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http://dx.doi.org/10.1210/er.2018-00163DOI Listing
January 2019

COmplexome Profiling ALignment (COPAL) reveals remodeling of mitochondrial protein complexes in Barth syndrome.

Bioinformatics 2019 Jan 14. Epub 2019 Jan 14.

CMBI, Radboud Centre for Mitochondrial Medicine, Radboud Institute for Molecular Life Sciences, 260 Radboud University Medical Centre, PO Box 9101, HB Nijmegen.

Motivation: Complexome profiling combines native gel electrophoresis with mass spectrometry to obtain the inventory, composition and abundance of multiprotein assemblies in an organelle. Applying complexome profiling to determine the effect of a mutation on protein complexes requires separating technical and biological variations from the variations caused by that mutation.

Results: We have developed the COmplexome Profiling ALignment (COPAL) tool that aligns multiple complexome profiles with each other. Read More

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http://dx.doi.org/10.1093/bioinformatics/btz025DOI Listing
January 2019

Polycystic ovary syndrome: is the cardiometabolic risk increased after menopause?

Menopause 2019 Jan 14. Epub 2019 Jan 14.

Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania.

Although more commonly known for its fertility sequelae, dermatologic, metabolic, and psychological morbidities associated with polycystic ovary syndrome (PCOS) are not well recognized. This Practice Pearl reviews the effect of PCOS on cardiometabolic risk during the reproductive years and the consequence of these findings in middle-aged women. Current screening and management recommendations are reviewed. Read More

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http://Insights.ovid.com/crossref?an=00042192-900000000-9743
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http://dx.doi.org/10.1097/GME.0000000000001286DOI Listing
January 2019
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Association of sedentary behavior and metabolic syndrome.

Public Health 2019 Jan 12;167:96-102. Epub 2019 Jan 12.

Department of Physical Education, School of Sciences, São Paulo State University - UNESP. 14-01 Luiz Edmundo Carrijo Coube Av., 17033-360, Bauru, Brazil.

Objectives: To examine the association of sedentary behavior (SB) with metabolic syndrome (MetS) in adults, as well as to identify the impact of physical inactivity and economic condition on such association.

Study Design: This is a cross-sectional study.

Methods: This study was conducted in the city of Bauru, São Paulo State, Brazil (n = 970). Read More

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http://dx.doi.org/10.1016/j.puhe.2018.11.007DOI Listing
January 2019

Ferritin levels throughout childhood and metabolic syndrome in adolescent stage.

Nutr Metab Cardiovasc Dis 2018 Dec 4. Epub 2018 Dec 4.

Division of Child Development and Community Health, University of California, San Diego, La Jolla, CA, USA.

Background And Aim: Increased ferritin levels have been widely associated with cardiovascular risk in adults. Whether ferritin levels and their changes during childhood are related to metabolic syndrome (MetS) at adolescence is unknown. We aimed to evaluate these associations using levels of ferritin at 5, 10 and 16 years and their linear increases and patterns of sustained increased levels across childhood. Read More

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http://dx.doi.org/10.1016/j.numecd.2018.11.008DOI Listing
December 2018

Associations of metabolically healthy obesity with prevalence and progression of coronary artery calcification: Results from the Heinz Nixdorf Recall Cohort Study.

Nutr Metab Cardiovasc Dis 2018 Nov 15. Epub 2018 Nov 15.

Center of Clinical Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Medical Faculty, University Duisburg-Essen, Essen, Germany; School of Public Health, Department of Epidemiology, Boston University, 715 Albany, Street, Talbot Building, Boston, MA 02118, USA.

Background And Aims: There is controversy on the potentially benign nature of metabolically healthy obesity (MHO), i.e., obese persons with few or no metabolic abnormalities. Read More

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http://dx.doi.org/10.1016/j.numecd.2018.11.002DOI Listing
November 2018

In vitro α-amylase and pancreatic lipase inhibitory activity of Cornus mas L. and Cornus alba L. fruit extracts.

J Food Drug Anal 2019 Jan 3;27(1):249-258. Epub 2018 Jul 3.

Department of Pharmacognosy and Molecular Basis of Phytotherapy, Medical University of Warsaw, Banacha 1, 02-097, Warsaw, Poland. Electronic address:

Less-common fruits from Cornus spp. (Cornaceae), also named dogwoods, have shown antidiabetic, antibacterial and anti-allergic properties and are thus considered a source of phytochemicals that are beneficial to human health. The study aimed to compare the chemical compositions of the aqueous and ethanolic extracts of lyophilized fresh-picked and commercially available dried fruits of Cornus mas (Cm, cornelian cherry) and Cornus alba (Ca) fruits using HPLC-DAD-MS/MS method. Read More

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http://dx.doi.org/10.1016/j.jfda.2018.06.005DOI Listing
January 2019

Pathophysiological mechanisms linking type 2 diabetes and dementia: Review of evidence from clinical, translational and epidemiological research.

Curr Diabetes Rev 2019 Jan 15. Epub 2019 Jan 15.

Department of Endocrinolgy and Metabolism. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico.

Background: Type 2 diabetes represents an increasing health burden world-wide and its prevalence in particularly higher in elderly population. Consistent epidemiological evidence suggests an increased risk of dementia associated to type 2 diabetes; the mechanisms underlying these associations, however, remain unclear.

Objective: To review epidemiological, clinical and pre-clinical data that weigh on pathophysiological links, mechanisms of disease and associations between type 2 diabetes and dementia to identify areas of opportunity for future research. Read More

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http://dx.doi.org/10.2174/1573399815666190115151500DOI Listing
January 2019

Impact of curcumin on energy metabolism in HIV infection: A case study.

Phytother Res 2019 Jan 15. Epub 2019 Jan 15.

Center of Health Science, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.

Prolonged use of antiretroviral therapy (ART) has been associated with dyslipidemia and impaired energy substrate oxidation (SOxi). Curcumin is a natural bioactive compound, which interacts with molecular targets and holds important metabolic properties. The aim of this study was to evaluate the effect of curcumin supplementation on energetic metabolism of an adult female with HIV/AIDS and under ART. Read More

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http://doi.wiley.com/10.1002/ptr.6258
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http://dx.doi.org/10.1002/ptr.6258DOI Listing
January 2019
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Physiologic and pathologic effects of dietary free fatty acids on cells of the joint.

Ann N Y Acad Sci 2019 Jan 15. Epub 2019 Jan 15.

Department of Orthopaedic Surgery, Washington University, St. Louis, Missouri.

Fatty acids (FAs) are potent organic compounds that not only can be used as an energy source during nutrient deprivation but are also involved in several essential signaling cascades in cells. Therefore, a balanced intake of different dietary FAs is critical for the maintenance of cellular functions and tissue homeostasis. A diet with an imbalanced fat composition creates a risk for developing metabolic syndrome and various musculoskeletal diseases, including osteoarthritis (OA). Read More

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http://dx.doi.org/10.1111/nyas.13999DOI Listing
January 2019

A New Insight into the Roles of MiRNAs in Metabolic Syndrome.

Biomed Res Int 2018 17;2018:7372636. Epub 2018 Dec 17.

Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.

Metabolic syndrome (MetS), which includes several clinical components such as abdominal obesity, insulin resistance (IR), dyslipidemia, microalbuminuria, hypertension, proinflammatory state, and oxidative stress (OS), has become a global epidemic health issue contributing to a high risk of type 2 diabetes mellitus (T2DM). In recent years, microRNAs (miRNAs), used as noninvasive biomarkers for diagnosis and therapy, have aroused global interest in complex processes in health and diseases, including MetS and its components. MiRNAs can exist stably in serum, liver, skeletal muscle (SM), heart muscle, adipose tissue (AT), and cells, because of their ability to escape the digestion of RNase. Read More

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http://dx.doi.org/10.1155/2018/7372636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311798PMC
December 2018

Madelung's disease: long-term follow-up.

J Surg Case Rep 2019 Jan 9;2019(1):rjy356. Epub 2019 Jan 9.

Department of Human Pathology, Matsunami General Hospital, 185-1, Dendai, Kasamatsu, Hashima-gun, Gifu, Japan.

Madelung's disease (MD) is a rare lipid metabolic disorder of adipose tissue overgrowth, which has been reported to be related to alcohol abuse. Although it does not affect survival itself, alcoholism and metabolic disorders associated with MD can be life-threatening. Although surgical procedures and classifications have been reported, long-term follow-up has rarely been reported. Read More

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http://dx.doi.org/10.1093/jscr/rjy356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326107PMC
January 2019

The Relation Between Free Testosterone and Components of Metabolic Syndrome in Women With Polycystic Ovary Syndrome.

J Family Reprod Health 2018 Mar;12(1):1-7

Reproductive Health Research Center, Guilan University of Medical Sciences, Rasht, Iran.

To assess the relationship between free testosterone level and components of MS in women with PCOS. This is a cross-sectional study which was conducted on 215 women with PCOS. PCOS was diagnosed based on the Rotterdam criteria. Read More

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Estimation of cardiosurgical intervention risk according to EuroSCORE in patients with acute coronary syndrome and different gallbladder conditions before coronary artery bypass grafting.

Kardiochir Torakochirurgia Pol 2018 Dec 31;15(4):238-240. Epub 2018 Dec 31.

Department of Family Medicine, Lviv National Medical University named after Danylo Halytsky, Lviv, Ukraine.

Introduction: Estimation of cardiosurgical intervention risk according to EuroSCORE is an important aspect of cardiosurgery. EuroSCORE allows prediction of the probability of a post-operational fatal outcome.

Aim: To estimate the influence of gallbladder condition on the prognosis after coronary artery bypass grafting (CABG) and and the interactions between metabolic background and cardiosurgical intervention risk. Read More

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http://dx.doi.org/10.5114/kitp.2018.80920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329887PMC
December 2018

Metabolic Syndrome and Its Components Predict the Risk of Type 2 Diabetes Mellitus in the Mainland Chinese: A 3-Year Cohort Study.

Int J Endocrinol 2018 13;2018:9376179. Epub 2018 Dec 13.

Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Introduction: It has well established that metabolic syndrome (MetS) can predict the risk of type 2 diabetes mellitus (T2DM) in some population groups. However, limited evidence is available regarding the predictive effect of MetS for incident T2DM in mainland Chinese population.

Methods: A 3-year cohort study was performed for 9735 Chinese without diabetes at baseline. Read More

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http://dx.doi.org/10.1155/2018/9376179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311882PMC
December 2018

Increase of body mass index and waist circumference predicts development of metabolic syndrome criteria in apparently healthy individuals with 2 and 5 years follow-up.

Int J Obes (Lond) 2019 Jan 15. Epub 2019 Jan 15.

Internal Medicine Department "C", "D" &"E", The Tel Aviv-Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: The metabolic syndrome (MetS) is associated with overweight and abdominal obesity. Our aim was to use longitudinal measurements to provide clinically relevant information on the relative influence of changes in body mass index (BMI), waist circumference (WC), and weekly physical exercise duration on the development of each of the MetS components.

Methods: We analyzed data collected at the Tel-Aviv Medical Center Inflammation Survey (TAMCIS). Read More

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http://dx.doi.org/10.1038/s41366-018-0312-xDOI Listing
January 2019

Transcriptomic signature reveals mechanism of flower bud distortion in witches'-broom disease of soybean (Glycine max).

BMC Plant Biol 2019 Jan 15;19(1):26. Epub 2019 Jan 15.

Centre for Agricultural Bioinformatics, ICAR-Indian Agricultural Statistics Research Institute, Library Avenue, PUSA, New Delhi, 110012, India.

Background: Soybean (Glycine max L. Merril) crop is major source of edible oil and protein for human and animals besides its various industrial uses including biofuels. Phytoplasma induced floral bud distortion syndrome (FBD), also known as witches' broom syndrome (WBS) has been one of the major biotic stresses adversely affecting its productivity. Read More

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http://dx.doi.org/10.1186/s12870-018-1601-1DOI Listing
January 2019

The pressing need for standardization in epidemiologic studies of PCOS across the globe.

Gynecol Endocrinol 2019 Jan 16:1-3. Epub 2019 Jan 16.

d Department of Obstetrics and Gynecology Medical College of Georgia , Augusta University , Augusta , GA , USA.

The polycystic ovary syndrome (PCOS) is a common and important complex endocrine metabolic disorder affecting women mainly in the reproductive age. The prevalence of the disorder varies depending on the epidemiologic design and criterion used to study the disease. This variation in methodology and subsequent effect on epidemiologic estimate makes it difficult to compare prevalences and phenotypes across geographical areas and assess the effect of cultural and racial variations on PCOS phenotypes. Read More

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http://dx.doi.org/10.1080/09513590.2018.1488958DOI Listing
January 2019

[Group preventive consulting influence on body mass correction and nutrition disorders. 5-year prospective survey].

Vopr Pitan 2016 23;85(3):49-60. Epub 2016 Jun 23.

Tyumen State Medical University.

The aim of the work was to analyze education technologies efficacy using group methods of prevention (body mass correction school) in patients with overweight and obesity, living in Extreme North, according to a 5-year prospective survey. 181 Extreme North alien inhabitants have been investigated (23.2% men, 76. Read More

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http://dx.doi.org/10.24411/0042-8833-2016-00035DOI Listing

[The study of energy balance in individuals with the Trp64Arg polymorphism of the β3-adrenoreceptor gene].

Vopr Pitan 2016 23;85(3):42-48. Epub 2016 Jun 23.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

The study involved 104 people living in the Moscow region, including 18 men and 86 women aged 18 to 67 years. Genotyping of rs4994 ADRB3 polymorphisms was performed using allele-specific amplification, with result detection in real time and using TaqMan-probes complementary to polymorphic DNA regions. The frequency of the mutant allele in individuals was 8. Read More

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http://dx.doi.org/10.24411/0042-8833-2016-00034DOI Listing

[Efficiency of polyphenol-rich grape products for the prevention of metabolic disorders in the experiment].

Vopr Pitan 2017 28;86(1):100-107. Epub 2016 Dec 28.

North Caucasian Regional Research Institute of Horticulture and Viticulture, Krasnodar.

The article presents the results of study of the effect of polyphenol-rich materials obtained from grapes on the clinical symptoms, activity of non-specific proteases, and parameters of lipid peroxidation (LPO) of blood of rats with fructose model of metabolic syndrome (MS). White male rats (n=54, with initial body weight of 190-210 g) were randomly divided into five groups: control and 4 experimental groups. Body weight, circumference of the abdomen, blood serum level of glucose, total cholesterol, triglycerides and high density (HDL) lipoproteins were monitored in all animals in dynamics. Read More

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http://dx.doi.org/10.24411/0042-8833-2017-00027DOI Listing
December 2016

[The effectiveness of com bined treatment with simbiotiks and antioxidants in patients with periodontal disease and metabolic syndrome].

Vopr Pitan 2017 28;86(1):87-92. Epub 2016 Dec 28.

I.M. Sechenov First Moscow State Medical University.

The article discusses the pathophysiological mechanisms of the relationship between inflammatory periodontal diseases and metabolic syndrome (MS). Clinical and biochemical assessment of the dynamics of indicators of lipid blood profile, carbohydrate metabolism and oxidative stress has been conducted in patients with periodontal disease and MS. We examined and treated 73 patients aged from 35 to 55 years with clinical and biochemical features of the MS (body mass index (BMI) >25 kg/m, abdominal type of obesity, impaired glucose tolerance and atherogenic dyslipidemia). Read More

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http://dx.doi.org/10.24411/0042-8833-2017-00025DOI Listing
December 2016

[Assessment of the relationship of inflammation markers, adipokines and parameters of lipid metabolism in patient].

Vopr Pitan 2017 28;86(1):41-47. Epub 2016 Dec 28.

Samara State Medical University.

Objective - to assess the changes and the relationship of inflammation markers, adipokine levels and lipid metabolism in overweight and obesity, with signs of the metabolic syndrome. The study involved 62 women aged from 25 to 50 years. Group 1 included women (n=20) with a BMI<27. Read More

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http://dx.doi.org/10.24411/0042-8833-2017-00019DOI Listing
December 2016

[Treating Type 2 Diabetes Mellitus Patients Complicated with Metabolic Syndrome by Benefiting Qi Dissolving Method].

Zhongguo Zhong Xi Yi Jie He Za Zhi 2016 Sep;36(9):1065-1071

Objective To observe clinical efficacy of Yiqi Huaju Recipe (YHR) combined routine Western medical treatment on type 2 diabetes mellitus (T2DM) patients complicated metabolic syndrome (MetS). Methods Totally 96 T2DM patients complicated MetS were assigned to the treatment group (YHR +routine Western drugs) and the control group (placebo +routine Western drugs) according to random digit table, 48 cases in each group. The therapeutic course for all was 12 weeks. Read More

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September 2016

[Importance of sleep and circadian rhythm for energy metabolism].

Internist (Berl) 2019 Jan 15. Epub 2019 Jan 15.

Medizinische Klinik I, Universitätsklinikum Schleswig-Holstein, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

The circadian clock is a complex and highly specialized network of the human organism and is key for metabolic health. Circadian rhythms are modulated by behavioral patterns, physical activity, food intake as well as sleep loss and sleep disorders. Furthermore, an altered expression of clock genes (e. Read More

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http://dx.doi.org/10.1007/s00108-018-0543-xDOI Listing
January 2019

Physical activity counteracts metabolic syndrome-induced hypogonadotropic hypogonadism and erectile dysfunction in the rabbit.

Am J Physiol Endocrinol Metab 2019 Jan 15. Epub 2019 Jan 15.

University of Florence, Italy.

Metabolic syndrome (MetS) clusters cardiovascular and metabolic risk factors, along with hypogonadism (HG) and erectile dysfunction (ED). Lifestyle modifications including physical exercise (PhyEx) are well-known treatments for this condition. In this study, we analyzed the effect of PhyEx on hypothalamus-pituitary-testis axis and erectile function using an animal MetS model, previously established in rabbits fed a high fat diet (HFD). Read More

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http://dx.doi.org/10.1152/ajpendo.00377.2018DOI Listing
January 2019

High prevalence of metabolic alterations in Latin American patients at initial stages of psychosis.

Early Interv Psychiatry 2019 Jan 15. Epub 2019 Jan 15.

Early Intervention Program, J. Horwitz Psychiatric Institute, Santiago, Chile.

Aim: Studies conducted in the United States have highlighted a higher prevalence of metabolic alterations (MA) in Latino population and Latino psychotic patients. Metabolic risk in psychosis is known to be present from initial stages of the disease. To better characterize this population, we explored the prevalence of MA and metabolic syndrome (MS) in early psychosis patients in a Latin American country. Read More

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http://dx.doi.org/10.1111/eip.12777DOI Listing
January 2019

The antileukemic effects of saffron (Crocus sativus L.) and its related molecular targets: A mini review.

J Cell Biochem 2019 Jan 15. Epub 2019 Jan 15.

Department of New Sciences and Technology, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Saffron (Crocus sativus L.), and its main constituents, crocin, and crocetin have shown promising effects as an antileukemic agent in animal models and cell culture systems. Saffron retards the growth of cancer cells via inhibiting nucleic acid synthesis and enhancing antioxidative system. Read More

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http://dx.doi.org/10.1002/jcb.27525DOI Listing
January 2019

Patient empowerment and the Mediterranean diet as a possible tool to tackle prediabetes associated with overweight or obesity: a pilot study.

Hormones (Athens) 2019 Jan 14. Epub 2019 Jan 14.

Department of Clinical Medicine and Surgery, University "Federico II", Via Sergio Pasini 5, 80121, Naples, Italy.

Aim: The objective of this study was to investigate the effect of implementation of short-term patient empowerment as applied to Mediterranean diet (MD) adherence on metabolic and anthropometric parameters in prediabetic overweight or obese subjects.

Methods: The sample included 42 subjects with prediabetes, aged 18-75 years and with body mass index (BMI) > 25 kg/m, who received dietary advice on MD by nutritionists during session groups every 2 weeks for 4 months. Data on energy caloric intake and macronutrient consumption were collected using a 7-day food diary record. Read More

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http://dx.doi.org/10.1007/s42000-018-0090-9DOI Listing
January 2019

Association between serum zinc and copper levels and antioxidant defense in subjects infected with human T-lymphotropic virus type 1.

J Blood Med 2019 27;10:29-35. Epub 2018 Dec 27.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran,

Introduction: Copper (Cu) and zinc (Zn) are important trace elements that are also structural ions of superoxide dismutase (SOD), which reduce oxidative stress. Zinc deficiency and excess copper have been reported to be associated with inflammation. The human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus, which is believed to cause systemic inflammation. Read More

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http://dx.doi.org/10.2147/JBM.S184913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312056PMC
December 2018

Prevalence and Incidence of Atrial Fibrillation in the General Population Based on National Health Insurance Special Health Checkups - TAMA MED Project-AF.

Circ J 2019 Jan 11. Epub 2019 Jan 11.

Department of Cardiovascular Medicine, Nippon Medical School.

Background: Although National Health Insurance special health checkups have been useful for the diagnosis of metabolic syndrome, they are insufficient to identify atrial fibrillation (AF). In Tama City in Tokyo, 12-lead electrocardiogram has been included as an essential examination in special health checkups to diagnose AF since 2008. Methods and Results: In subjects aged 40-74 years at entry, prevalence of AF was 0. Read More

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http://dx.doi.org/10.1253/circj.CJ-18-1038DOI Listing
January 2019

Homeostasis of Glucose and Lipid in Non-Alcoholic Fatty Liver Disease.

Int J Mol Sci 2019 Jan 13;20(2). Epub 2019 Jan 13.

Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.

Industrialized society-caused dysregular human behaviors and activities such as overworking, excessive dietary intake, and sleep deprivation lead to perturbations in the metabolism and the development of metabolic syndrome. Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease worldwide, affects around 30% and 25% of people in Western and Asian countries, respectively, which leads to numerous medical costs annually. Insulin resistance is the major hallmark of NAFLD and is crucial in the pathogenesis and for the progression from NAFLD to non-alcoholic steatohepatitis (NASH). Read More

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http://dx.doi.org/10.3390/ijms20020298DOI Listing
January 2019
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Altered Adipose Tissue DNA Methylation Status in Metabolic Syndrome: Relationships Between Global DNA Methylation and Specific Methylation at Adipogenic, Lipid Metabolism and Inflammatory Candidate Genes and Metabolic Variables.

J Clin Med 2019 Jan 13;8(1). Epub 2019 Jan 13.

Unidad de Gestión Clínica de Endocrinología y Nutrición del Hospital Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, 29010 Málaga, Spain.

Metabolic syndrome (MetS) has been postulated to increase the risk for type 2 diabetes, cardiovascular disease and cancer. Adipose tissue (AT) plays an important role in metabolic homeostasis, and AT dysfunction has an active role in metabolic diseases. MetS is closely related to lifestyle and environmental factors. Read More

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http://dx.doi.org/10.3390/jcm8010087DOI Listing
January 2019

Beneficial Effects of an Aged Black Garlic Extract in the Metabolic and Vascular Alterations Induced by a High Fat/Sucrose Diet in Male Rats.

Nutrients 2019 Jan 12;11(1). Epub 2019 Jan 12.

Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid. C/Arzobispo Morcillo n°2 28029 Madrid, Spain.

Aged black garlic (ABG) is a functional food with antioxidant and anti-inflammatory properties. Recent studies also report its beneficial metabolic effects in a context of obesity or diabetes, although the mechanisms involved are poorly understood. The aim of this work was to analyze the effects of an ABG extract in the vascular and metabolic alterations induced by a high-fat/sucrose diet in rats. Read More

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http://dx.doi.org/10.3390/nu11010153DOI Listing
January 2019

Relationship of leukocytes, platelet indices and adipocytokines in metabolic syndrome patients.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):874-880. Epub 2018 Dec 20.

Biochemistry Division, Chemistry Department, Faculty of Science, Beni-Suef University, Egypt.

Aims: The current study aimed to explore the correlation between leukocytes and platelets indices with adipocytokines (leptin and adiponectin) and MetS components.

Methods: A total of 100 healthy subjects and 200 patients diagnosed with different MetS components were enrolled in the study. Eligible patients were allocated into four groups (50 patients). Read More

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http://dx.doi.org/10.1016/j.dsx.2018.12.016DOI Listing
December 2018

Association Between dietary patterns and the risk of metabolic syndrome among Iranian population: A cross-sectional study.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):858-865. Epub 2018 Dec 1.

Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: The role of dietary patterns in metabolic syndrome has not been investigated sufficiently among Iranian population. The aim of this study is to investigate the association of major dietary patterns with the risk of metabolic syndrome and its components among healthy individuals of Iran.

Methods: This is a cross-sectional study that was performed on 5895 men and women who participated in MASHAD study project. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.11.059DOI Listing
December 2018

Metabolic syndrome and its components are related to a higher risk for albuminuria and proteinuria: Evidence from a meta-analysis on 10,603,067 subjects from 57 studies.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):830-843. Epub 2018 Dec 8.

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address:

Background & Aim: Previous studies have explored the relation of metabolic syndrome (MetS), its components and the risk of albuminuria/proteinuria but their results are inconsistent. Then, we aimed to conduct a meta-analysis in order to resolve these controversies.

Method: PubMed and Scopus were systematically searched from their inception to 1 march 2018. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.12.006DOI Listing
December 2018

Prevalence of metabolic syndrome in Gwalior region of Central India: A comparative study using NCEP ATP III, IDF and Harmonized criteria.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):816-821. Epub 2018 Dec 8.

School of Studies in Biochemistry, Jiwaji University, Gwalior, Madhya Pradesh, India. Electronic address:

Background: The aim of this study is to determine the prevalence of Metabolic syndrome (MetS) in the people of Gwalior. Three criteria viz., National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria, International Diabetes Federation (IDF) criteria and Harmonized criteria for MetS were employed to assess the prevalence of metabolic syndrome in this region, their concordance with respect to this population was recorded. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.12.003DOI Listing
December 2018

Prevalence of metabolic syndrome in Iran: A meta-analysis of 69 studies.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):792-799. Epub 2018 Dec 5.

Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. Electronic address:

Aims: Metabolic syndrome increases the risk of chronic diseases including cardiovascular diseases and diabetes. The present study investigated the prevalence of metabolic syndrome in Iran.

Materials And Methods: Published articles in English and Persian during 2000-2016 identified using keywords of prevalence, metabolic syndrome, and Iran in the following databases: Web of Science, PubMed, Scopus, Google scholar, SID and Magiran. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.11.055DOI Listing
December 2018

The association between serum irisin levels and cardiovascular disease in diabetic patients.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):786-790. Epub 2018 Nov 30.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Cardiovascular disease is the most common cause of mortality and morbidity in diabetic patients. Insulin resistance has been shown to be reduced by the secretion of irisin from muscle and adipose tissues. This study was aimed at determining the relationship between serum irisin levels and angiographically defined coronary artery disease (CAD) in type II diabetic patients. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.11.050DOI Listing
November 2018

Metabolic syndrome components and prostatic hyperplasia among diabetic and non-diabetic men in the Eastern DR Congo: A cross-sectional study.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):776-780. Epub 2018 Dec 5.

Department of Urology, Université Catholique de Louvain (UCL). Brussels, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18714021183052
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http://dx.doi.org/10.1016/j.dsx.2018.11.064DOI Listing
December 2018
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The morphofunctional features of platelets against the background of metabolic syndrome in patients with generalized marginal periodontitis.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):730-733. Epub 2018 Dec 3.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Department of Operative Surgery and Topographic Anatomy, Moscow, Russia.

According to modern ideas, disorders in the system of hemostasis in cardiovascular diseases are mainly due to an increase in the functional activity of platelets, namely their increased ability to adhere and aggregate. Aim of the research was to evaluate morphofunctional platelets of patients with marginal periodontitis. Material and methods of the study involved 129 men aged 28-50 years (mean age 42. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.11.057DOI Listing
December 2018

Hypertriglyceridaemic waist is associated with hyperuricaemia and metabolic syndrome in rheumatoid arthritis patients.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):722-729. Epub 2018 Dec 1.

Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, Mexico. Electronic address:

Background: /Aim: The hypertriglyceridaemic waist (HTGW) phenotype has been described and suggested in general population as a cardiovascular risk marker. The aim of the present study was to evaluate the HTGW phenotype as a marker related to HUC and MetS in rheumatoid arthritis (RA).

Materials And Methods: This was a cross-sectional study was designed in 250 RA Mexicans patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18714021183053
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http://dx.doi.org/10.1016/j.dsx.2018.11.053DOI Listing
December 2018
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High rates of atherogenic dyslipidemia, β-cell function loss, and microangiopathy among Turkish migrants with T2DM.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):716-720. Epub 2018 Nov 24.

Division of Cardiology, Cliniques universitaires St-Luc and Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Brussels, Belgium.

Aims: Non-Caucasian migrants require dedicated approaches in diabetes management due to specific genetic; socio-cultural; demographic and anthropological determinants. Documenting such phenotypes allows for better understanding unmet needs and management priorities.

Methods: This age- and sex-adjusted case-control (1:6 ratio) study compared 56 T2DM Turkish migrants (70% males) resident in Belgium [Tu] with 336 T2DM Caucasians [Ca], all benefiting from state-funded healthcare. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.11.049DOI Listing
November 2018