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BMJ Support Palliat Care 2022 Jun 28. Epub 2022 Jun 28.

Geisinger Medical Center, Danville, Pennsylvania, USA.

We report an 80-year-old woman who developed severe hypophosphataemia and elevated urinary phosphate levels while started on valproic acid. This occurred within 1-2 days of starting valproic acid. There are rare single-patient reports of the association of valproic acid with adult Fanconi syndrome. Read More

Cell Rep Med 2022 Jun 21:100670. Epub 2022 Jun 21.

Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, University of Lorraine, INSERM UMR_S 1256, 54000 Nancy, France; Reference Center for Inborn Errors of Metabolism (ORPHA67872), University Hospital of Nancy, 54000 Nancy, France; Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, 54000 Nancy, France. Electronic address:

Inherited disorders of B metabolism produce a broad spectrum of manifestations, with limited knowledge of the influence of age and the function of related genes. We report a meta-analysis on 824 patients with a genetically proven diagnosis of an inherited disorder of vitamin B metabolism. Gene clusters and age categories are associated with patients' manifestations. Read More

Diabetes Metab Syndr 2022 Jun 20;16(7):102544. Epub 2022 Jun 20.

Department of Pediatrics and Clinical Epidemiology, Sitaram Bhartia Institute of Science and Research, New Delhi, 110016, India.

Background And Aims: Unhealthy food environment at work is believed to be playing a role in the burgeoning obesity, cardiometabolic risk, diabetes and cardiovascular diseases in India. Therefore, food environment assessment at work is crucial to understand the effect of food environment and to find its association with cardiometabolic risk among adults in Delhi, India.

Methodology: Mix-methods study to find association between worksite food environment on the food choices, dietary behavior, and cardio-metabolic health of 455 apparently healthy adults (both males and females) aged 25-55 years was done in urban India. Read More

Endocrine 2022 Jun 28. Epub 2022 Jun 28.

Department of Endocrinology and Metabolic Diseases, Cardiovascular and Metabolic Unit, CHU-Larrey, Toulouse, France.

Since the Covid-19 pandemic emerged in 2019, several adenoviral-vectored, mRNA-based and inactivated whole-virus vaccines have been developed. A massive vaccination campaign has been undertaken around the world, and an increasing number of SARS-CoV-2 vaccine-induced thyroid diseases have been described in the literature. Subacute thyroiditis has been reported in 52 patients, mean age 45. Read More

Circ Res 2022 Jun 28:101161CIRCRESAHA122320783. Epub 2022 Jun 28.

Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, OH (Z.Y., Z.L., V.P.-G., M.G., Y.M., M.G.).

Clin Genet 2022 Jun 27. Epub 2022 Jun 27.

Division of Pediatric Gastroenterology and Hepatology, Department of Pediatric Liver, Kidney and Metabolic Diseases, Hannover Medical School, Hannover, Germany.

Respir Res 2022 Jun 27;23(1):172. Epub 2022 Jun 27.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Street, Wenzhou, 325000, China.

Background: Acute respiratory distress syndrome (ARDS) is a challenging clinical problem. Discovering the potential metabolic alterations underlying the ARDS is important to identify novel therapeutic target and improve the prognosis. Serum and urine metabolites can reflect systemic and local changes and could help understanding metabolic characterization of community-acquired pneumonia (CAP) with ARDS. Read More

J Med Case Rep 2022 Jun 28;16(1):252. Epub 2022 Jun 28.

Department of Oncology, Keck School of Medicine of USC, Los Angeles, CA, USA.

Background: Tumor lysis syndrome is an oncologic emergency that involves multiple metabolic abnormalities and clinical symptoms such as acute renal failure, cardiac arrhythmias, seizures, and multiorgan failure, and may be fatal if not promptly recognized. Tumor lysis syndrome occurs most often in patients with hematologic malignancies, and relatively few cases have been described in patients with sarcoma.

Case Presentation: A 64-year-old male of Asian heritage presented to his primary care physician with a right lower-extremity mass and was ultimately diagnosed with widely metastatic osteosarcoma. Read More

BMC Endocr Disord 2022 Jun 27;22(1):166. Epub 2022 Jun 27.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, and Berlin Institut of Health, SPZ Interdisziplinär, Kinderendokrinologie und -diabetologie, Augustenburger Platz 1, 13353, Berlin, Germany.

Background: Differences in sexual development (DSD) are rare diseases, which affect the chromosomal, anatomical or gonadal sex differentiation. Although patient education is recommended as essential in a holistic care approach, standardised programmes are still lacking. The present protocol describes the aims, study design and methods of the Empower-DSD project, which developed an age-adapted multidisciplinary education programme to improve the diagnosis-specific knowledge, skills and empowerment of patients and their parents. Read More

BMC Cardiovasc Disord 2022 Jun 27;22(1):295. Epub 2022 Jun 27.

Department of Public Health, Centre for Rehabilitation Research, Aarhus University, P.P. Oerumsgade 11, building 1 b, 8000 Aarhus C, Aarhus, Denmark.

Aim: The benefits of cardiac rehabilitation (CR) after acute coronary syndrome (ACS) are well established. However, the relative benefit of CR in those with comorbidities, including diabetes, is not well understood. This systematic review and meta-analysis examined the benefit of CR on exercise capacity and secondary outcomes in ACS patients with a co-diagnosis of diabetes compared to those without. Read More

J Physiol 2022 Jun 27. Epub 2022 Jun 27.

Institute for Health and Sport (iHeS), Victoria University, Melbourne, Victoria, Australia.

Polycystic ovary syndrome (PCOS) is characterised by a hormonal imbalance affecting the reproductive and metabolic health of reproductive-aged women. Exercise is recommended as a first-line therapy for women with PCOS to improve their overall health; however, women with PCOS are resistant to the metabolic benefits of exercise training. Here, we aimed to gain insight into the mechanisms responsible for such resistance to exercise in PCOS. Read More

J Epidemiol Community Health 2022 Jun 27. Epub 2022 Jun 27.

Netherlands Interdisciplinary Demographic Institute (NIDI)-KNAW/University of Groningen, The Hague, The Netherlands.

Background: This study investigates (1) whether different employment transition types (ie, unemployment, work disability, early retirement and regular retirement) are associated with metabolic syndrome (MetS) incidence among older workers (50-64 years) and (2) whether occupational group moderates the association between employment transition type and MetS incidence.

Methods: A sample of 13 303 older Dutch workers from the Lifelines Cohort Study and Biobank was examined using longitudinal data from two comprehensive measurement waves with a mean follow-up time of 3.7 years. Read More

Fish Shellfish Immunol 2022 Jun 24. Epub 2022 Jun 24.

School of Agriculture, Ludong University, Yantai, 264025, PR China. Electronic address:

Infectious hypodermal and haematopoietic necrosis virus (IHHNV) is the smallest known virus in shrimp, which causes runt-deformity syndrome (RDS) and leads to huge economic loss every year in penaeid shrimp farming. Previous studies have shown that the juvenile Penaeus vannamei is more susceptible to IHHNV infection than the adults, but the mechanism is still unclear. In order to investigate the mechanism of pathogenic differences in IHHNV infection of P. Read More

Exp Gerontol 2022 Jun 24:111873. Epub 2022 Jun 24.

Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, Santa Catarina, Brazil. Electronic address:

Introduction: The consumption of soft drinks has increased considerably in recent decades, mainly cola soft drinks. Excessive consumption of cola-based soft drinks is associated with several diseases and cognitive decline, particularly memory impairment. Furthermore, diets with high sugar can promote insulin resistance, metabolic syndrome, and dyslipidemia. Read More

J Affect Disord 2022 Jun 24. Epub 2022 Jun 24.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Public Health, Amsterdam Neuroscience, Amsterdam, the Netherlands.

Background: Structural brain alterations are observed in major depressive disorder (MDD). However, MDD is a highly heterogeneous disorder and specific clinical or biological characteristics of depression might relate to specific structural brain alterations. Clinical symptom subtypes of depression, as well as immuno-metabolic dysregulation associated with subtypes of depression, have been associated with brain alterations. Read More

Nurs Res 2022 Jul-Aug 01;71(4):E28-E38. Epub 2022 Mar 4.

Background: Midlife perimenopausal and postmenopausal women with metabolic syndrome experience multiple symptoms concurrently.

Objective: The study objectives were to examine the relationship among symptoms through network visualization and identify and compare symptom clusters and key symptoms across symptom occurrence and symptom severity dimensions in midlife perimenopausal and postmenopausal women with and without metabolic syndrome.

Methods: Cross-sectional data from the Study of Women's Health Across the Nation (Visit 5) were used for analysis. Read More

Am J Physiol Cell Physiol 2022 Jun 27. Epub 2022 Jun 27.

Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montréal, Canada.

Gene mutations in the extracellular matrix protein fibrillin-1 cause connective tissue disorders including Marfan syndrome (MFS) with clinical symptoms in the cardiovascular, skeletal, and ocular systems. MFS patients also exhibit alterations in adipose tissues, which in some individuals leads to lipodystrophy, whereas in others to obesity. We have recently demonstrated that fibrillin-1 regulates adipose tissue homeostasis. Read More

Sports Med Open 2022 Jun 27;8(1):84. Epub 2022 Jun 27.

Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital in Prague and 1st Faculty of Medicine, Charles University, Na Bojišti 3, Praha 2, 12000, Prague, Czech Republic.

Objectives: Bilirubin is a potent endogenous antioxidant and immunomodulating substance, which is also implicated in both cell signalling and various metabolic pathways. Mild elevation of systemic bilirubin concentrations provides substantial protection against many diseases of civilization. Rare published reports have suggested that serum bilirubin might also be relevant to sports performance. Read More

Wiad Lek 2022 ;75(5 pt 1):1077-1082

UKRAINIAN MILITARY MEDICAL ACADEMY, KYIV, UKRAINE.

Objective: The aim: To study the impact of nutritional correction of protein metabolism disorders on the clinical course of pulmonary tuberculosis.

Patients And Methods: Materials and methods: The study involved 67 patients with pulmonary tuberculosis, which were divided into two groups: group I - 35 patients who underwent nutritional correction of protein metabolism disorders against the background of antimycobacterial therapy (AMBT) and group II - 32 patients who received standard AMBT. An assessment of clinical indicators and the condition of protein metabolism (PM) was conducted by determining the concentration of individual non-essential, essential amino acids and their total amount. Read More

Chronobiol Int 2022 Jun 27:1-7. Epub 2022 Jun 27.

Diseases, Qazvin University of Medical SciencesMetabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable, Qazvin, Iran.

The association of social jetlag (SJL), as a quantitative measure of circadian misalignment, with insulin resistance and metabolic syndrome has been reported. The present study was designed to investigate the association of SJL with gestational diabetes mellitus (GDM). Pregnant women with gestational age ≤14 weeks were enrolled in this longitudinal study. Read More

J Inherit Metab Dis 2022 Jun 27. Epub 2022 Jun 27.

Department of Neurology and Clinical Neurophysiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, RB, Groningen, the Netherlands.

Introduction: Inborn errors of metabolism are genetic disorders that need to be recognized as early as possible because treatment may be available. In late-onset forms, core symptoms are movement disorders, psychiatric symptoms, and cognitive impairment. Eye movement disorders are considered to be frequent too, although specific knowledge is lacking. Read More

Metabol Open 2022 Sep 14;15:100195. Epub 2022 Jun 14.

Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, PO Box: 812, Yaounde, Cameroon.

Objective: To determine antioxidant potentials of seeds extracts and three formulation-based extracts , and to evaluate the effects of the best formulation on oxidative stress and dyslipidemia on rats fed with high fat and high sucrose diet (HFHSD).

Methods: Aqueous extracts of , and three formulations were mixed at various portions (A. s/P. Read More

Front Public Health 2022 9;10:902393. Epub 2022 Jun 9.

School of Medicine and Dentistry, Griffith University, Gold Coast, QLD, Australia.

Purpose: This study aimed to investigate the association between serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and incident metabolic disease in a cohort of community-based older Chinese people.

Patients And Methods: Five thousand healthy Gaohang residents who attended community health checks at the Shanghai East Hospital in 2013 were recruited. Biological, biochemical, and lifestyle variables were collected. Read More

Front Endocrinol (Lausanne) 2022 9;13:908727. Epub 2022 Jun 9.

Centre for Metabolic Bone Diseases, Department of Geriatrics, University Hospitals Leuven, Leuven, Belgium.

Glucocorticoids are effective immunomodulatory drugs used for many inflammatory disorders as well as in transplant recipients. However, both iatrogenic and endogenous glucocorticoid excess are also associated with several side effects including an increased risk of osteoporosis and fractures. Glucocorticoid-induced osteoporosis (GIOP) is a common secondary cause of osteoporosis in adults. Read More

Front Endocrinol (Lausanne) 2022 9;13:868572. Epub 2022 Jun 9.

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Obesity, altered glucose homeostasis, hyperinsulinism, and reproductive dysfunction develops in female humans and mammals with hyperandrogenism. We previously reported that low dose dihydrotestosterone (DHT) administration results in metabolic and reproductive dysfunction in the absence of obesity in female mice, and conditional knock-out of the androgen receptor (Ar) in the liver (LivARKO) protects female mice from DHT-induced glucose intolerance and hyperinsulinemia. Since altered metabolic function will regulate reproduction, and liver plays a pivotal role in the reversible regulation of reproductive function, we sought to determine the reproductive phenotype of LivARKO mice under normal and hyperandrogenemic conditions. Read More

Front Endocrinol (Lausanne) 2022 9;13:893142. Epub 2022 Jun 9.

Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Background: Animal studies have found that GPHB5 has a similar effect on system metabolism as TSH. However, the relationship between GPHB5 and metabolic diseases remains unknown. This study investigates the relationship between GPHB5 and MetS in young women. Read More

Compr Psychoneuroendocrinol 2021 May 17;6:100048. Epub 2021 Mar 17.

Ralph H. Johnson VA Medical Center, Charleston, SC, 29425, United States.

Growing evidence indicates that disturbances in the inflammatory response system can have deleterious effects on neuronal function and mental health. While the correlation between elevated peripheral inflammatory markers and psychiatric disorders are well documented, the exact molecular and neuronal mechanism underlying the connection between activated inflammation and neuropsychiatric behaviour remain elusive. Microglia activation is the key interface between neuro-inflammation and manifestation of psychiatric symptoms. Read More

Front Nutr 2022 9;9:891339. Epub 2022 Jun 9.

AgroBioSciences Department, Mohammed VI Polytechnic University, Ben-Guerir, Morocco.

The metabolic syndrome (MS) is a multifactorial syndrome associated with a significant economic burden and healthcare costs. MS management often requires multiple treatments (polydrug) to ameliorate conditions such as diabetes mellitus, insulin resistance, obesity, cardiovascular diseases, hypertension, and non-alcoholic fatty liver disease (NAFLD). However, various therapeutics and possible drug-drug interactions may also increase the risk of MS by altering lipid and glucose metabolism and promoting weight gain. Read More

J Dent Sci 2022 Apr 23;17(2):1018-1023. Epub 2021 Nov 23.

Department of Medicine, Hualien Armed Forces General Hospital, Hualien, Taiwan.

Background/purpose: To investigate the associations between treated and untreated dental caries and periodontitis in young adults.

Materials And Methods: The study enrolled 1289 participants aged 18-45 years in Taiwan. Localized periodontitis was categorized into healthy and stage II/III (n = 936 and n = 353, respectively) based on the 2017 criteria of the World Workshop. Read More

Clin Kidney J 2022 Jul 15;15(7):1284-1289. Epub 2022 Apr 15.

Physiology Department, Instituto Universitario del Hospital Italiano de Buenos Aires, Argentina.

Organ crosstalk allows the interaction between systems to adapt to a constant changing environment, maintaining homeostasis. The process of placentation and the new hormonal environment during pregnancy trigger physiological changes that modulate kidney function to control extracellular volume, acid-base balance and filtration of metabolic waste products. The bidirectional communication means that acute or chronic dysfunction of one organ can compromise the other. Read More