75,502 results match your criteria Metabolic Syndrome


Infectious encephalitis: mimics and chameleons.

Pract Neurol 2019 Mar 16. Epub 2019 Mar 16.

Department of Neurology, Chelsea and Westminster Hospital, London, UK

'Query encephalitis' is a common neurological consultation in hospitalised patients. Identifying the syndrome is only part of the puzzle. Although historically encephalitis has been almost synonymous with infection, we increasingly recognise parainfectious or postinfectious as well as other immune-mediated causes. Read More

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http://dx.doi.org/10.1136/practneurol-2018-002114DOI Listing

Metabolic Syndrome Associated with Increased Rates of Medical Complications Following Intracranial Tumor Resection.

World Neurosurg 2019 Mar 13. Epub 2019 Mar 13.

Division of Neurosurgery, University of Texas Medical Branch, Galveston, TX, USA.

Background: When diagnosed simultaneously, obesity, diabetes, and hypertension form a medical constellation called metabolic syndrome (MetS). The prevalence of MetS in Western cultures has been on a steady ascent and MetS has been associated with increased postoperative complications in multiple surgical settings.

Objective: In this study, we evaluate the relationship between MetS and the outcomes of craniotomy for supratentorial brain tumor. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.046DOI Listing

Epicardial fat: the role of testosterone and lipid metabolism in a cohort of patients with Klinefelter syndrome.

Metabolism 2019 Mar 13. Epub 2019 Mar 13.

Centre for Rare Diseases, Policlinico Umberto I, Rome, Italy; Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy.

Context: Klinefelter syndrome (KS), in which subjects have additional copies of X chromosomes, is the most common male sex chromosome abnormality, with a prevalence of 1 in 660 and an incidence of about 1 in 500-700 newborns. Its sign and symptoms include infertility, generally low testosterone levels, and an increased prevalence of obesity and metabolic syndrome. Epicardial fat thickness (EFT) reflects visceral adiposity rather than general obesity. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.03.002DOI Listing

Expression of the plasminogen system in the physiological mouse ovary and in the pathological polycystic ovary syndrome (PCOS) state.

Reprod Biol Endocrinol 2019 Mar 16;17(1):33. Epub 2019 Mar 16.

School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, 3083, Australia.

Background: The fibrinolytic system and its inhibitors play a number of roles, apart from their function in blood haemostasis and thrombosis, namely in ovarian folliculogenesis and in ovulation. Plasminogen is converted to active plasmin at the time of follicular rupture through a decrease in plasminogen activator inhibitor-1 (PAI-1) and an increase in plasminogen activators. Oligo-/anovulation and follicle arrest are key characteristics of PCOS, but studies evaluating fibrinolytic/proteolytic markers within human or animal PCOS ovaries are lacking. Read More

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http://dx.doi.org/10.1186/s12958-019-0472-0DOI Listing

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi007-A from a Long QT Syndrome type 1 patient carrier of two common variants in the NOS1AP gene.

Stem Cell Res 2019 Mar 6;36:101416. Epub 2019 Mar 6.

Coronary Care Unit and Laboratory of Experimental Cardiology for Cell and Molecular Therapy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.; Department of Molecular Medicine, Unit of Cardiology, Università degli studi di Pavia, Pavia, Italy.; Department of Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

We generated human induced pluripotent stem cells (hiPSCs) from a symptomatic Long QT Syndrome (LQTS) type 1 patient, belonging to a South African (SA) founder population segregating the heterozygous mutation c.1022C > T p.A341V on the KCNQ1 gene. Read More

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http://dx.doi.org/10.1016/j.scr.2019.101416DOI Listing

Artificial intelligence based discovery of the association between depression and chronic fatigue syndrome.

J Affect Disord 2019 Mar 8;250:380-390. Epub 2019 Mar 8.

Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address:

Background: Both of the modern medicine and the traditional Chinese medicine classify depressive disorder (DD) and chronic fatigue syndrome (CFS) to one type of disease. Unveiling the association between depressive and the fatigue diseases provides a great opportunity to bridge the modern medicine with the traditional Chinese medicine.

Methods: In this work, 295 general participants were recruited to complete Zung Self-Rating Depression Scales and Chalder Fatigue Scales, and meanwhile, to donate plasma and urine samples for H NMR-metabolic profiling. Read More

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http://dx.doi.org/10.1016/j.jad.2019.03.011DOI Listing

Lower Leg Fat Depots Are Associated with Albuminuria Independently of Obesity, Insulin Resistance, and Metabolic Syndrome (Korea National Health and Nutrition Examination Surveys 2008 to 2011).

Diabetes Metab J 2019 Mar 7. Epub 2019 Mar 7.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.

Background: Although the involvement of obesity in metabolic disorders is well known, leg fat depot influences on albuminuria have not been determined.

Methods: This population-based, cross-sectional study used a nationally representative sample of 2,076 subjects aged ≥20 years from the Korea National Health and Nutrition Examination Surveys of 2008 to 2011. The ratio of leg fat to total fat (LF/TF ratio) was assessed by dual X-ray absorptiometry, and albuminuria was defined as more than one positive dipstick test or an albumin-to-creatinine ratio of ≥30 mg/g. Read More

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http://dx.doi.org/10.4093/dmj.2018.0081DOI Listing

Impact of Longitudinal Changes in Metabolic Syndrome Status over 2 Years on 10-Year Incident Diabetes Mellitus.

Diabetes Metab J 2019 Feb 20. Epub 2019 Feb 20.

Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

Background: Metabolic syndrome (MetS) is a known predictor of diabetes mellitus (DM), but whether longitudinal changes in MetS status modify the risk for DM remains unclear. We investigated whether changes in MetS status over 2 years modify the 10-year risk of incident DM.

Methods: We analyzed data from 7,317 participants aged 40 to 70 years without DM at baseline, who took part in 2001 to 2011 Korean Genome Epidemiology Study. Read More

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http://dx.doi.org/10.4093/dmj.2018.0111DOI Listing
February 2019

The Protective Effects of Increasing Serum Uric Acid Level on Development of Metabolic Syndrome.

Diabetes Metab J 2019 Feb 21. Epub 2019 Feb 21.

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: It has not been determined whether changes in serum uric acid (SUA) level are associated with incident metabolic syndrome (MetS). The aim of the current study was to investigate the relationship between changes in SUA level and development of MetS in a large number of subjects.

Methods: In total, 13,057 subjects participating in a medical health check-up program without a diagnosis of MetS at baseline were enrolled. Read More

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http://dx.doi.org/10.4093/dmj.2018.0079DOI Listing
February 2019

A Comparative Study Evaluating the Incidence of Colorectal Neoplasia(s) in Candidates for Bariatric Surgery by Screening Colonoscopy, 40-49 Versus 50-65 Years Old: a Preliminary Study.

Obes Surg 2019 Mar 15. Epub 2019 Mar 15.

İstanbul Bariatrics, Obesity and Advanced Laparoscopy Center, Hakkı Yeten Cad, Yeşil Çimen sok, Polat Tower, Şişli, 34394, İstanbul, Turkey.

Introduction: Obesity and metabolic syndrome (MetS) are associated with colorectal neoplasia (CRN) and carcinoma (CRC). Whether such subjects must undergo screening colonoscopy (SC) earlier, is unknown. Incidences of CRNs in 40-49- versus 50-65-year-old bariatric patients were compared by SC. Read More

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http://link.springer.com/10.1007/s11695-019-03819-2
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http://dx.doi.org/10.1007/s11695-019-03819-2DOI Listing
March 2019
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The emerging concept of "individualized cholesterol-lowering therapy": A change in paradigm.

Pharmacol Ther 2019 Mar 12. Epub 2019 Mar 12.

Klinik für Innere Medizin I, Universitätsklinikum Jena, Jena, Germany. Electronic address:

High LDL-cholesterol concentrations constitute a risk for atherosclerotic cardiovascular disease. By consensus, cholesterol-lowering therapy is initiated with a statin that reduces endogenous cholesterol synthesis, upregulates hepatic LDL receptor activity, increases LDL clearance and lowers LDL-cholesterol concentrations in the bloodstream. The efficacy of statin treatment is dose dependent and achieves a risk reduction of up to 50%. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2019.03.004DOI Listing

Infant Psychosocial Environment Predicts Adolescent Cardiometabolic Risk: A Prospective Study.

J Pediatr 2019 Mar 12. Epub 2019 Mar 12.

Center for Human Growth and Development, University of Michigan, Ann Arbor, MI; Department of Pediatrics, University of California San Diego, San Diego, CA.

Objective: To prospectively assess whether the infant psychosocial environment was associated with cardiometabolic risk as early as adolescence.

Study Design: Participants were recruited in Santiago, Chile, and have been followed from infancy. Inclusion criteria included healthy infants with birth weight ≥3 kg and a stable caregiver. Read More

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http://dx.doi.org/10.1016/j.jpeds.2019.01.058DOI Listing

The Mediterranean Diet: From an Environment-Driven Food Culture to an Emerging Medical Prescription.

Int J Environ Res Public Health 2019 Mar 15;16(6). Epub 2019 Mar 15.

Diabetes, Nutrition and Metabolic Diseases, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.

The Mediterranean diet originates in the food cultures of ancient civilizations which developed around the Mediterranean Basin and is based on the regular consumption of olive oil (as the main source of added fat), plant foods (cereals, fruits, vegetables, legumes, tree nuts, and seeds), the moderate consumption of fish, seafood, and dairy, and low-to-moderate alcohol (mostly red wine) intake, balanced by a comparatively limited use of red meat and other meat products. A few decades ago, the Mediterranean diet drew the attention of medical professionals by proving extended health benefits. The first reports ascertained cardiovascular protection, as multiple large-scale clinical studies, starting with Ancel Keys' Seven Countries Study, showed a marked reduction of atherosclerotic clinical events in populations with a Mediterranean dietary pattern. Read More

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http://dx.doi.org/10.3390/ijerph16060942DOI Listing

Glycemia Lowering Effect of an Aqueous Extract of Leaves in Diabetic Rodent Models.

Nutrients 2019 Mar 14;11(3). Epub 2019 Mar 14.

School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.

has a long history of use worldwide as a food and in folk medicine. In this study, we aimed to investigate the effect of an aqueous extract of leaves (HC) on type 2 diabetes mellitus (T2DM). Two types of animal models were used in this study: Streptozotocin (STZ)-induced T2DM (Wistar rats; = 8) and C57BKSdb/db mice ( = 5). Read More

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http://dx.doi.org/10.3390/nu11030629DOI Listing

Associations between Macronutrient Intakes and Obesity/Metabolic Risk Phenotypes: Findings of the Korean National Health and Nutrition Examination Survey.

Nutrients 2019 Mar 14;11(3). Epub 2019 Mar 14.

Department of Family Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

Obesity is a risk factor for many health issues, as are metabolic abnormalities. However, few studies have addressed the associations between obesity/metabolic risk phenotypes and dietary macronutrient intakes (carbohydrate, protein, and fat). Therefore, this study examined the associations between macronutrient intakes and obesity/metabolic risk phenotypes in a Korean population. Read More

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http://dx.doi.org/10.3390/nu11030628DOI Listing

Influence of Living Arrangements and Eating Behavior on the Risk of Metabolic Syndrome: A National Cross-Sectional Study in South Korea.

Int J Environ Res Public Health 2019 Mar 14;16(6). Epub 2019 Mar 14.

Red Cross College of Nursing, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Korea.

Studies on the relationships between health, different living arrangements, and eating behaviors across age groups are limited. Therefore, we investigated these associations, focusing on metabolic syndrome, among 16,015 South Koreans aged ≥19 years who completed the Korean National Health and Nutrition Examination Survey (2013⁻2016). Multivariate logistic regression revealed that younger adults (<65 years) who lived and ate alone consumed more carbohydrates than those who lived and ate with others ( < 0. Read More

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http://dx.doi.org/10.3390/ijerph16060919DOI Listing

Statins and nonalcoholic fatty liver disease in the era of precision medicine: More friends than foes.

Atherosclerosis 2019 Mar 3;284:66-74. Epub 2019 Mar 3.

Operating Unit of Internal and Metabolic Medicine, Azienda Ospedaliero-Universitaria of Modena, Civil Hospital of Baggiovara, Via Giardini 1355, 41126, Modena, Italy.

Nonalcoholic fatty liver disease (NAFLD) describes a spectrum of alcohol-like hepatic histological changes, which occur in the absence of any competing causes of chronic liver disease, notably including significant alcohol consumption. A close and bi-directional relationship links NAFLD with the metabolic syndrome (MetS), and concurrent MetS will hasten the progression to more severe forms of NAFLD, including cirrhosis and hepatocellular carcinoma (HCC). Patients with NAFLD will typically exhibit atherogenic dyslipidemia and increased cardiovascular risk (CVR). Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.02.028DOI Listing

Shaping the future heart: transgenerational outcomes of maternal metabolic syndrome.

Am J Physiol Heart Circ Physiol 2019 Mar 15. Epub 2019 Mar 15.

Pediatrics, Nationwide Childrens Hospital and Ohio State University, United States.

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http://dx.doi.org/10.1152/ajpheart.00156.2019DOI Listing

AZATAX: Acetazolamide safety and efficacy in cerebellar syndrome in PMM2-CDG.

Ann Neurol 2019 Mar 14. Epub 2019 Mar 14.

Genetic Medicine Department and Pediatric Institute of Rare Diseases, Institut de Recerca Hospital Sant Joan de Déu Barcelona, Barcelona, Spain.

Objective: Phosphomannomutase deficiency (PMM2-CDG) causes cerebellar syndrome and stroke-like episodes (SLEs). SLEs are also described in patients with gain-of-function mutations in the CaV2.1 channel, for which acetazolamide therapy is suggested. Read More

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http://dx.doi.org/10.1002/ana.25457DOI Listing

The effects of trans-resveratrol on insulin resistance, inflammation, and microbiota in men with the metabolic syndrome: A pilot randomized, placebo-controlled clinical trial.

J Clin Transl Res 2019 Jan 7;4(2):122-135. Epub 2018 Dec 7.

Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York.

Background And Aim: The metabolic syndrome (MetS) is a pathological condition comprised of abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. It has become a major threat globally, resulting in rapidly increasing rates of diabetes, coronary heart disease, and stroke. The polyphenol resveratrol (RES) is believed to improve glucose homeostasis and insulin resistance by activating sirtuin, which acetylates and coactivates downstream targets and affects glucose and lipid homeostasis in the liver, insulin secretion in the pancreas, and glucose uptake in skeletal muscle. Read More

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January 2019
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Additional Impact of Glucose Tolerance on Telomere Length in Persons With and Without Metabolic Syndrome in the Elderly Ukraine Population.

Front Endocrinol (Lausanne) 2019 28;10:128. Epub 2019 Feb 28.

Laboratory of Epigenetics, Chebotariov Institute of Gerontology, Kyiv, Ukraine.

Association between different components of metabolic syndrome and the rate of age-related telomere shortening was reported repeatedly, although some findings are inconsistent across studies, suggesting the need for further research on the topic. In the present study, we examined relationships between different components of metabolic syndrome (MetS); glucose tolerance reflected in 2-h post-load plasma glucose (2hPG) levels and age on the leukocyte telomere length (LTL) in Ukraine population. The study was conducted on the 115 adult individuals residing in the Kyiv region (Ukraine). Read More

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http://dx.doi.org/10.3389/fendo.2019.00128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404635PMC
February 2019

Low Physical Activity and Cardiorespiratory Fitness in People With Schizophrenia: A Comparison With Matched Healthy Controls and Associations With Mental and Physical Health.

Front Psychiatry 2019 28;10:87. Epub 2019 Feb 28.

Department of Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands.

The aim of this study was to objectively assess time spent in physical activity (PA) and sedentary behavior (SB) in patients with schizophrenia compared to healthy controls matched for age, gender and socioeconomic status. Associations between both PA and cardiorespiratory fitness (CRF) and mental and physical health parameters in patients with schizophrenia were examined. Moderate and vigorous PA (MVPA), moderate PA, vigorous PA, total and active energy expenditure (TEE and AEE), number of steps, lying down and sleeping time was assessed with SenseWear Pro-2 body monitoring system for three 24-h bouts in patients with schizophrenia ( = 63) and matched healthy controls ( = 55). Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404550PMC
February 2019

Metabolic syndrome components including high abdominal obesity and sarcopenia in patients with inflammatory bowel disease.

Ann Gastroenterol 2019 Mar-Apr;32(2):214. Epub 2019 Jan 15.

Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Macedonia, Greece (Jannis Kountouras, Michael Doulberis, Stergios A. Polyzos, Panagiotis Katsinelos).

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http://dx.doi.org/10.20524/aog.2019.0349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394267PMC
January 2019

Obesity hypoventilation syndrome.

Eur Respir Rev 2019 Mar 14;28(151). Epub 2019 Mar 14.

CIBER de enfermedades respiratorias (CIBERES), Madrid, Spain.

Obesity hypoventilation syndrome (OHS) is defined as a combination of obesity (body mass index ≥30 kg·m), daytime hypercapnia (arterial carbon dioxide tension ≥45 mmHg) and sleep disordered breathing, after ruling out other disorders that may cause alveolar hypoventilation. OHS prevalence has been estimated to be ∼0.4% of the adult population. Read More

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http://err.ersjournals.com/lookup/doi/10.1183/16000617.0097-
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http://dx.doi.org/10.1183/16000617.0097-2018DOI Listing
March 2019
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The Goddess Who Spins the Thread of Life: Klotho, Psychiatric Stress, and Accelerated Aging.

Brain Behav Immun 2019 Mar 11. Epub 2019 Mar 11.

National Center for PTSD at VA Boston Healthcare System, Boston, MA, USA; Boston University School of Medicine, Department of Psychiatry, Boston, MA, USA.

Background: Longevity gene klotho (KL) is associated with age-related phenotypes but has not been evaluated against a direct human biomarker of cellular aging. We examined KL and psychiatric stress, including posttraumatic stress disorder (PTSD), which is thought to potentiate accelerated aging, in association with biomarkers of cellular aging.

Methods: 309 white, non-Hispanic genotyped veterans with measures of epigenetic age (DNA methylation age), telomere length (n = 252), inflammation (C-reactive protein), psychiatric symptoms, metabolic function, and white matter neural integrity (diffusion tensor imaging; n = 185). Read More

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http://dx.doi.org/10.1016/j.bbi.2019.03.007DOI Listing

Cardiometabolic Medicine: A Call for a New Subspeciality Training Track in Internal Medicine.

Am J Med 2019 Mar 11. Epub 2019 Mar 11.

Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology, Johns Hopkins School of Medicine. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.02.027DOI Listing

Green cardamom supplementation improves serum irisin, glucose indices, and lipid profiles in overweight or obese non-alcoholic fatty liver disease patients: a double-blind randomized placebo-controlled clinical trial.

BMC Complement Altern Med 2019 Mar 12;19(1):59. Epub 2019 Mar 12.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Background: Despite the reported health effects of cardamom on dyslipidemia, hepatomegaly, and fasting hyperglycemia, no human research has studied its potency in non-alcoholic fatty liver disease (NAFLD) as the hepatic part of metabolic syndrome. Our aim was determining the effects of green cardamom (GC) on serum glucose indices, lipids, and irisin level among overweight or obese NAFLD patients.

Methods: The place of participant recruitment was the polyclinic of the National Iranian Oil Company (NIOC) central hospital in Tehran. Read More

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http://dx.doi.org/10.1186/s12906-019-2465-0DOI Listing

Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice.

BMC Microbiol 2019 Mar 12;19(1):57. Epub 2019 Mar 12.

Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Diego, La Jolla, CA, 92093, USA.

Background: A majority of women with polycystic ovary syndrome (PCOS) have metabolic dysfunction that results in an increased risk of type 2 diabetes. We previously developed a pubertal mouse model using the aromatase inhibitor, letrozole, which recapitulates many of the reproductive and metabolic features of PCOS. To further our understanding of the effects of androgen excess, we compared the effects of letrozole treatment initiated in puberty versus adulthood on reproductive and metabolic phenotypes as well as on the gut microbiome. Read More

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http://dx.doi.org/10.1186/s12866-019-1425-7DOI Listing

Glycyrrhetinic Acid Improves Insulin-Response Pathway by Regulating the Balance between the Ras/MAPK and PI3K/Akt Pathways.

Nutrients 2019 Mar 12;11(3). Epub 2019 Mar 12.

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300353, China.

Glycyrrhetinic acid (GA), a bioactive component in the human diet, has been reported to improve hyperglycemia, dyslipidemia, insulin resistance and obesity in rats with metabolic syndrome. However, GA-specific target proteins and the mechanisms involved in the downstream signaling and cross-talk to improve insulin sensitivity have not been fully elucidated. In this study, the potential targets of GA were identified by chemical proteomics strategies using serial GA probes for target fishing and cell molecular imaging. Read More

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http://dx.doi.org/10.3390/nu11030604DOI Listing

Pharmacokinetic and Metabolomic Studies with BIO 300, a Nanosuspension of Genistein, in a Nonhuman Primate Model.

Int J Mol Sci 2019 Mar 12;20(5). Epub 2019 Mar 12.

Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, USUHS, Bethesda, MD 20814, USA.

Genistein is a naturally occurring phytoestrogen isoflavone and is the active drug ingredient in BIO 300, a radiation countermeasure under advanced development for acute radiation syndrome (H-ARS) and for the delayed effects of acute radiation exposure (DEARE). Here we have assessed the pharmacokinetics (PK) and safety of BIO 300 in the nonhuman primate (NHP). In addition, we analyzed serum samples from animals receiving a single dose of BIO 300 for global metabolomic changes using ultra-performance liquid chromatography (UPLC) quadrupole time-of-flight mass spectrometry (QTOF-MS). Read More

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http://dx.doi.org/10.3390/ijms20051231DOI Listing

Identifying mutations in epilepsy genes: Impact on treatment selection.

Epilepsy Res 2019 Mar 4;152:18-30. Epub 2019 Mar 4.

Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; Clinical Trial Center, IRCCS Mondino Foundation, Pavia, Italy.

The last decade saw impressive advances not only in the discovery of gene mutations causing epilepsy, but also in unraveling the molecular mechanisms underlying the clinical manifestations of the disease. Increasing evidence is emerging that understanding these mechanisms is relevant for selection of the most appropriate treatment in the affected individual(s). The present article discusses the therapeutic implications of epilepsy-causing variants affecting a broad range of targets, from ion channels to genes controlling cellular metabolism and cell signaling pathways. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.001DOI Listing

Further investigation of mitochondrial biogenesis and gene expression of key regulators in ascites- susceptible and ascites- resistant broiler research lines.

PLoS One 2019 14;14(3):e0205480. Epub 2019 Mar 14.

Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, AR, United States of America.

We have extended our previous survey of the association of mitochondrial prevalence in particular tissues with ascites susceptibility in broilers. We previously reported that in breast muscle of 22 week old susceptible line male birds had significantly higher mtDNA copy number relative to nuclear copy number (mtDNA/nucDNA), compared to resistant line male birds. The higher copy number correlated with higher expression of PPARGC1A mRNA gene. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205480PLOS

Health-related quality of life questionnaire for polycystic ovary syndrome (PCOSQ-50): a psychometric study with the Serbian version.

Women Health 2019 Mar 14:1-11. Epub 2019 Mar 14.

b Clinic of Endocrinology, Diabetes and Metabolic Diseases, Faculty of Medicine , University of Belgrade , Belgrade , Serbia.

This study aimed to analyze the measurement properties of the Health-related quality of life questionnaire for polycystic ovary syndrome (PCOSQ-50) in a sample of Serbian women with polycystic ovary syndrome (PCOS). Seventy-six women with PCOS from an endocrinology clinic and 28 healthy women participated between October 2016 and March 2017. The measure was rigorously translated and culturally adapted into Serbian. Read More

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http://dx.doi.org/10.1080/03630242.2019.1587664DOI Listing

Isocaloric Fructose Restriction Reduces Serum D-Lactate Concentration in Children With Obesity and Metabolic Syndrome.

J Clin Endocrinol Metab 2019 Mar 14. Epub 2019 Mar 14.

Glycation, Oxidation and Disease Laboratory, Department of Research, Touro University California College of Osteopathic Medicine, Vallejo, CA.

Objective: To investigate the link between dietary sugar consumption and two separate pathogenetic mechanisms associated with metabolic syndrome: de novo lipogenesis (DNL) and non-enzymatic glycation.

Design And Participants: We assessed changes in serum D-lactate (the detoxification end-product of methylglyoxal) concentration in response to nine days of isocaloric fructose restriction in 20 children with obesity and metabolic syndrome, and examined correlations with changes in DNL, liver fat, insulin sensitivity and other metrics of hepatic metabolism.

Interventions: Nine days of dietary sugar restriction, with substitution of equal amounts of refined starch. Read More

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http://dx.doi.org/10.1210/jc.2018-02772DOI Listing

[Clinical evaluation of a psoriatic patient].

Authors:
Mathilde Kemula

Rev Prat 2018 Nov;68(9):966-971

Service de dermatologie, hôpital Tarnier-Cochin, Paris, France.

Clinical evaluation of a psoriatic patient. Psoriasis is a frequent and burdening inflammatory dermatosis. It affects the quality of life of patients in a deep and sustained way, even if the disease is not very extensive. Read More

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November 2018

Effects of Colchicine in Adults with Metabolic Syndrome: A Pilot Randomized Controlled Trial.

Diabetes Obes Metab 2019 Mar 14. Epub 2019 Mar 14.

Section on Growth and Obesity, Division of Intramural Research (DIR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD.

Aims: Low-grade inflammation is believed to contribute to the metabolic dysregulation of obesity. Colchicine can reduce inflammation by inhibiting microtubule propagation and inflammasome assembly. We evaluated efficacy and safety of colchicine for improving metabolic and inflammatory outcomes in people with obesity and metabolic syndrome (MetS). Read More

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http://dx.doi.org/10.1111/dom.13702DOI Listing

Apolipoprotein M: a novel adipokine decreasing with obesity and upregulated by calorie restriction.

Am J Clin Nutr 2019 Mar 14. Epub 2019 Mar 14.

Franco-Czech Laboratory for Clinical Research on Obesity, Third Faculty of Medicine, Prague and Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Toulouse, France.

Background: The adipose tissue (AT) is a secretory organ producing a wide variety of factors that participate in the genesis of metabolic disorders linked to excess fat mass. Weight loss improves obesity-related disorders.

Objectives: Transcriptomic studies on human AT, and a combination of analyses of transcriptome and proteome profiling of conditioned media from adipocytes and stromal cells isolated from human AT, have led to the identification of apolipoprotein M (apoM) as a putative adipokine. Read More

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http://dx.doi.org/10.1093/ajcn/nqy331DOI Listing

Novel Cinnamic Acid Derivatives as Potential PPARδ Agonists for Metabolic Syndrome: Design, Synthesis, Evaluation and Docking Studies.

Curr Drug Discov Technol 2019 Mar 14. Epub 2019 Mar 14.

Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh. India.

Peroxisome proliferator-activated receptor (PPAR) δ is expressed universally in the entire tissues, particularly in those concerned with the lipid metabolism. PPAR δ stimulation alters body's energy fuel preference to fat from glucose and shows up as an emerging pharmacological target for the treatment of metabolic disorders. A new series of cinnamic acid derivatives was synthesized and evaluated for the antidiabetic and antiinflammatory activities in the animal models followed by in silico docking studies to determine the binding interactions for the best fit conformations in the binding site of the PPARδ protein. Read More

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http://dx.doi.org/10.2174/1570163816666190314124543DOI Listing

Association Of Non-Alcoholic Fatty Liver Disease With Serum Uric Acid.

J Ayub Med Coll Abbottabad 2019 Jan-Mar;31(1):64-66

Department of Surgery, Ayub Medical College Abbottabad, Pakistan.

Background: Non-alcoholic fatty liver disorder is a clinicopathological condition, characterized by macro vesicular steatosis in hepatic cells and metabolic stress related disorders without other causes of chronic hepatic disease. Uric acid is basically a heterocyclic compound of hydrogen, carbon, oxygen and nitrogen. Uric acid is the metabolic end product of purine metabolism. Read More

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March 2019
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The interaction of high and low-risk human papillomavirus genotypes increases the risk of developing genital warts: A population-based cohort study.

J Cell Biochem 2019 Mar 13. Epub 2019 Mar 13.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Cervical cancer is among the most common type of cancers in women and is associated with human papillomavirus (HPV) infection. Genital warts are also reported to be linked with HPV infection types 11 and 6. In turn, clinical characteristics and morphological features of warts may be useful in the prediction of prognosis and in making treatment decisions. Read More

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http://dx.doi.org/10.1002/jcb.28557DOI Listing

Oral glucose effectiveness and metabolic risk in obese children and adolescents.

Acta Diabetol 2019 Mar 13. Epub 2019 Mar 13.

Research Unit for Multifactorial Diseases, Bambino Gesù Children's Hospital, Rome, Italy.

Aim: To investigate whether GE is affected in children/adolescents with obesity and abnormalities of the metabolic syndrome (MetS).

Methods: Cross-sectional study of oral GE (oGE), insulin sensitivity and secretion (calculated on 5 time-points oral glucose tolerance test) and metabolic abnormalities in 1012 patients with overweight/obesity (aged 6.0-17. Read More

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http://link.springer.com/10.1007/s00592-019-01303-y
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http://dx.doi.org/10.1007/s00592-019-01303-yDOI Listing
March 2019
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Hypoxia exposure alleviates impaired muscular metabolism, glucose tolerance, and aerobic capacity in apelin-knockout mice.

FEBS Open Bio 2019 Mar 23;9(3):498-509. Epub 2019 Jan 23.

School of Sport Science Beijing Sport University China.

High altitude hypoxia adaptation can improve glucose tolerance in people with metabolic syndrome and type 2 diabetes (T2D). Apelin is an endogenous ligand of the G protein-coupled receptor APJ and has possible roles in energy metabolism. Apelin-null mice have been reported to exhibit impaired insulin sensitivity, which can be reversed by supplementation of exogenous apelin. Read More

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http://dx.doi.org/10.1002/2211-5463.12587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396165PMC

Gitelman Syndrome: A Rare Cause of Seizure Disorder and a Systematic Review.

Case Rep Med 2019 5;2019:4204907. Epub 2019 Feb 5.

Resident Physician, Abington Hospital-Jefferson Health, Abington, PA, USA.

Gitelman syndrome is one of the few inherited causes of metabolic alkalosis due to salt losing tubulopathy. It is caused by tubular defects at the level of distal convoluted tubules, mimicking a thiazide-like tumor. It usually presents in late childhood or in teenage as nonspecific weakness, fatigability, polyuria, and polydipsia but very rarely with seizures. Read More

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http://dx.doi.org/10.1155/2019/4204907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379858PMC
February 2019

Comorbidities and Nonalcoholic Fatty Liver Disease: The Chicken, the Egg, or Both?

Fed Pract 2019 Feb;36(2):64-71

is a Staff Physician, and is Chief of Gastroenterology and Associate Chief of Medicine, both at VA Ann Arbor Healthcare System. is a Physician Affiliate and Director of the Cooperative Studies Program Epidemiology Centers at Durham VAMC in North Carolina. is Chief of Hepatology and Liver Transplantation at Hunter Holmes McGuire VAMC. Christine Hunt is an Adjunct Associate Professor of Medicine at Duke University Medical Center in Durham. Lisa Glass is an Assistant Professor and Grace Su is a Professor of Medicine, both at the University of Michigan Medical School in Ann Arbor. Michael Fuchs is Professor of Medicine at Virginia Commonwealth University in Richmond.

Improvement in NAFLD may lead to improvement of metabolic syndrome, cardiovascular disease, and malignancy and vice versa. Read More

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February 2019

Metabolic syndrome alters relationships between cardiometabolic variables, cognition and white matter hyperintensity load.

Sci Rep 2019 Mar 13;9(1):4356. Epub 2019 Mar 13.

Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, United Kingdom.

Cardiometabolic risk factors influence white matter hyperintensity (WMH) development: in metabolic syndrome (MetS), higher WMH load is often reported but the relationships between specific cardiometabolic variables, WMH load and cognitive performance are uncertain. We investigated these in a Brazilian sample (aged 50-85) with (N = 61) and without (N = 103) MetS. Stepwise regression models identified effects of cardiometabolic and demographic variables on WMH load (from FLAIR MRI) and verbal recall performance. Read More

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http://dx.doi.org/10.1038/s41598-019-40630-6DOI Listing

Influence of metabolic syndrome on the relationship between fatty acids and the selected parameters in men with benign prostatic hyperplasia.

Aging (Albany NY) 2019 Mar;11(5):1524-1536

Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin 71-210, Poland.

The purpose of our investigation was to analyze the relationship between the serum levels of fatty acids and their metabolites and the levels of the selected metabolic and hormonal parameters in patients with benign prostatic hyperplasia (BPH) with regard to concomitant metabolic syndrome (MetS). We determined serum concentrations of total (TT) and free testosterone (FT), insulin (I), dehydroepiandrosterone sulphate (DHEAS), luteinizing hormone and insulin-like growth factor 1 (IGF-1) and sex hormone-binding globulin (SHBG). Gas chromatography was performed. Read More

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http://dx.doi.org/10.18632/aging.101850DOI Listing

High serum uric acid level is associated with greater handgrip strength in the aged population.

Arthritis Res Ther 2019 Mar 12;21(1):73. Epub 2019 Mar 12.

Division of Rheumatology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, #56, Dongsu-Ro, Bupyung-Gu, Incheon, South Korea.

Background: We aimed to investigate the association of serum UA level with muscle strength assessed by handgrip strength (HGS) in a large Korean adult population.

Methods: Cross-sectional data were obtained from the seventh Korea National Health and Nutrition Examination Survey (KNHANES) 2016. The KNHANES 2016 study included 8150 subjects, of whom 4230 subjects were analyzed in this study. Read More

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http://dx.doi.org/10.1186/s13075-019-1858-2DOI Listing

Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomised controlled study.

Clin Endocrinol (Oxf) 2019 Mar 13. Epub 2019 Mar 13.

Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, United Kingdom.

Background: Empagliflozin is a sodium-glucose-cotransporter-2 inhibitor that improves cardiovascular risk and promotes weight loss in patients with type 2 diabetes. Polycystic ovary syndrome (PCOS) is associated with obesity and increased cardiovascular risk; therefore, empagliflozin may be of benefit for these women. The aim of this study was to compare the effects of empagliflozin vs. Read More

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http://dx.doi.org/10.1111/cen.13968DOI Listing
March 2019
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Adipose tissue dysfunction in obese horses with Equine Metabolic Syndrome.

Equine Vet J 2019 Mar 13. Epub 2019 Mar 13.

Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, UK.

Background: Obesity is a common feature of equine metabolic syndrome (EMS). In other species obese adipose tissue shows pathological features such as adipocyte hypertrophy, fibrosis, inflammation and impaired insulin signalling all of which contribute to whole body insulin dysregulation. Such adipose tissue dysfunction has not been investigated in horses. Read More

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http://dx.doi.org/10.1111/evj.13097DOI Listing