83,599 results match your criteria Metabolic Syndrome


Obesity and Higher Risk for Severe Complications of Covid-19: What to do when the two pandemics meet.

J Popul Ther Clin Pharmacol 2020 Jun 29;27(S Pt 1):e31-e36. Epub 2020 Jun 29.

Co-Editor-in-Chief - Journal of Population Therapeutics and Clinical Pharmacology, Brisbane, QLD, Australia.

The coronavirus disease 2019 (COVID-19) pandemic has spread around the globe, infecting more than ten million individuals, with more than 500,000 dead; about one half of the infected people have recovered. Despite this fact, a subgroup of individuals affected by COVID-19 is at greater risk of developing worse outcomes and experience a high rate of mortality. Data on the association between obesity and COVID-19 are growing; the available studies, have reported a high prevalence of overweight and obesity in patients experiencing a severe COVID-19 course, with serious complications requiring hospitalization and admission to intensive care units. Read More

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http://dx.doi.org/10.15586/jptcp.v27iSP1.708DOI Listing

Prevalence of elevated liver enzymes and comorbidities in children and adolescents with overweight and obesity.

Acta Paediatr 2020 Jul 10. Epub 2020 Jul 10.

Institute of Liver Diseases, Lady Davis Carmel Medical Center, Haifa, Israel.

Aim: We investigated the prevalence of elevated liver aminotrasferases (ALT) and additional comorbidities in a large cohort of Israeli children and adolescents with overweight and obesity.

Methods: This study included data from medical records of 2 to 18 year old children and adolescents, with body mass index (BMI) in the overweight or obesity range (WHO definitions), for whom ALT testing was performed.

Results: Overweight was present in 50418 (10. Read More

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http://dx.doi.org/10.1111/apa.15469DOI Listing

Complex nutritional deficiencies in a large cohort of Italian patients with Cornelia de Lange syndrome spectrum.

Am J Med Genet A 2020 Jul 9. Epub 2020 Jul 9.

Department of Pediatrics, ASST-Lariana, Sant'Anna Hospital, San Fermo della Battaglia (Como), Italy.

Cornelia de Lange syndrome Spectrum (CdLSp) is characterized by intellectual disability, facial dysmorphisms, and growth impairment. Although eating difficulties are a well-known feature of the disease, there is no data regarding the nutritional deficiencies of these patients. The food intake was tracked using a dietary transcription provided by the family/caregivers, biochemical nutritional parameters were measured with laboratory tests and through an accurate clinical evaluation of the incidence of qualitative and quantitative imbalances in a cohort of 73 patients with CdLSp ware determined. Read More

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http://dx.doi.org/10.1002/ajmg.a.61749DOI Listing

Relationship between butyrylcholinesterase activity and lipid parameters in workers occupationally exposed to pesticides.

Environ Sci Pollut Res Int 2020 Jul 9. Epub 2020 Jul 9.

Laboratorio de Contaminación y Toxicología Ambiental, Secretaría de Investigación y Posgrado, Universidad Autónoma de Nayarit, Ciudad de la Cultura s/n. Col. Los Fresnos, 63190, Tepic, Nayarit, Mexico.

Exposure to organophosphate pesticides (OP) has been associated with the inhibition of cholinesterase enzymatic activity, such as butyrylcholinesterase (BuChE). Changes in BuChE activity have been associated with obesity, diabetes, hyperthyroidism, and metabolic syndrome. However, few studies have evaluated the effects of pesticides on both BuChE and lipid parameters. Read More

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http://dx.doi.org/10.1007/s11356-020-08197-2DOI Listing

The difference between steroid diabetes mellitus and type 2 diabetes mellitus: a whole-body F-FDG PET/CT study.

Acta Diabetol 2020 Jul 9. Epub 2020 Jul 9.

Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin 2nd Road, Shanghai, 200025, China.

Aims: Steroid diabetes mellitus (SDM) is a metabolic syndrome caused by an increase in glucocorticoids, and its pathogenesis is unclear. F-FDG PET/CT can reflect the glucose metabolism of tissues and organs under living conditions. Here, PET/CT imaging of SDM and type 2 diabetes mellitus (T2DM) rats was used to visualize changes in glucose metabolism in the main glucose metabolizing organs and investigate the pathogenesis of SDM. Read More

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http://dx.doi.org/10.1007/s00592-020-01566-wDOI Listing

[Causes, spectrum, and treatment of the diabetic neuropathy].

Nervenarzt 2020 Jul 9. Epub 2020 Jul 9.

Neurologie, Uniklinik RWTH Aachen, Pauwelsstr. 30, Aachen, Deutschland.

Background: Half of all diabetics are affected by a diabetic neuropathy. Microangiopathy, dysfunctional Schwann cell interactions, accumulation of toxic metabolites, and inflammatory processes all contribute to nerve damage.

Objective: Overview and perspectives of the pathophysiology as well as the current and future treatment implications. Read More

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http://dx.doi.org/10.1007/s00115-020-00948-3DOI Listing

The metabolic hypothesis is more likely than the epileptogenic hypothesis to explain stroke-like lesions.

Authors:
Josef Finsterer

Wellcome Open Res 2020 26;5:51. Epub 2020 Mar 26.

Krankenanstalt Rudolfstiftung, Messerli Institute, Vienna, 1180, Austria.

Stroke-like episodes (SLEs) are a hallmark of mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS) syndrome but occur in other mitochondrial disorders (MIDs) as well. The morphological equivalent of the SLE is the stroke-like lesion (SLL) on magnetic resonance imaging (MRI). The pathophysiology of SLLs is under debate, but several hypotheses have been raised to explain the phenomenon. Read More

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http://dx.doi.org/10.12688/wellcomeopenres.15758.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324943PMC

A case study of three patients with mucopolysaccharidoses in Hue Central Hospital.

SAGE Open Med Case Rep 2020 29;8:2050313X20938245. Epub 2020 Jun 29.

Pediatric Center, Hue Central Hospital, Hue City, Vietnam.

Mucopolysaccharidosis is a group of rare metabolic disorders characterized by a deficiency of enzymes in the degradation of glycosaminoglycans. The incomplete degradation process leads to the accumulation of glycosaminoglycans in lysosomes of various tissues, which interferes with cell function. We report three cases that were classified as Hurler-Mucopolysaccharidosis I, Morquio-Mucopolysaccharidosis IV A, and Maroteaux-Lamy-Mucopolysaccharidosis VI. Read More

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http://dx.doi.org/10.1177/2050313X20938245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325546PMC

Clinical Features and Natural History of PRKAG2 Variant Cardiac Glycogenosis.

J Am Coll Cardiol 2020 Jul;76(2):186-197

Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology, Hospital Universitario Puerta de Hierro, Madrid, Spain; Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares, Madrid, Spain; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart; Universidad Francisco de Vitoria, Pozuelo de Alarcon, Spain. Electronic address:

Background: PRKAG2 gene variants cause a syndrome characterized by cardiomyopathy, conduction disease, and ventricular pre-excitation. Only a small number of cases have been reported to date, and the natural history of the disease is poorly understood.

Objectives: The aim of this study was to describe phenotype and natural history of PRKAG2 variants in a large multicenter European cohort. Read More

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http://dx.doi.org/10.1016/j.jacc.2020.05.029DOI Listing

Daily consumption of one teaspoon of trehalose can help maintain glucose homeostasis: a double-blind, randomized controlled trial conducted in healthy volunteers.

Nutr J 2020 Jul 9;19(1):68. Epub 2020 Jul 9.

Hayashibara Co. Ltd., 675 Fujisaki, Naka-ku, Okayama, 702-8006, Japan.

Background: Trehalose is a natural disaccharide that is widely distributed. A previous study has shown that daily consumption of 10 g of trehalose improves glucose tolerance in individuals with signs of metabolic syndrome. In the present study, we determined whether a lower dose (3. Read More

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http://dx.doi.org/10.1186/s12937-020-00586-0DOI Listing

Oral Administration of Sodium Nitrate to Metabolic Syndrome Patients Attenuates Mild Inflammatory and Oxidative Responses to Acute Exercise.

Antioxidants (Basel) 2020 Jul 7;9(7). Epub 2020 Jul 7.

Research Group in Community Nutrition and Oxidative Stress, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma, Spain.

The beneficial effects of exercise for the treatment and prevention of metabolic syndrome pathologies have been related to its anti-inflammatory and antioxidant effects. Dietary nitrate supplementation is an emerging treatment strategy to alleviate the symptoms of metabolic syndrome affections and to improve vascular function. In this double-blind crossover trial, metabolic syndrome patients performed two exercise tests for 30 min at 60-70% maximal heart rate after the intake of a placebo or a nitrate-enriched beverage. Read More

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http://dx.doi.org/10.3390/antiox9070596DOI Listing

Metabolic syndrome components and disease disability in egyptian multiple sclerosis patients.

Mult Scler Relat Disord 2020 Jul 3;44:102336. Epub 2020 Jul 3.

Neurology Department, Faculty of Medicine, Zagazig University; Sharkia, Egypt.

Background: There is limited and inconsistent data on metabolic syndrome (MetS) in multiple sclerosis (MS) patients. The aim of this study was to estimate the frequency of MetS and its components in MS patients and to evaluate their association with disease disability in Egyptian MS patients.

Methods: A cross-section study was carried out on 60 patients (19 males and 41 females) with relapsing remitting MS. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102336DOI Listing

The hallmark of pro- and anti-inflammatory cytokine ratios in women with polycystic ovary syndrome.

Cytokine 2020 Jul 6;134:155187. Epub 2020 Jul 6.

Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Polycystic Ovary Syndrome (PCOS) is a heterogeneous endocrinopathy considered to be the most common metabolic disorder in women of reproductive age. Women with PCOS present with an increased risk of noncommunicable diseases (NCDs), especially low-grade chronic inflammation mediated by proinflammatory cytokines, and insulin resistance. This study aimed to investigate cytokine levels and their ratios in PCOS women compared to a healthy control group. Read More

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http://dx.doi.org/10.1016/j.cyto.2020.155187DOI Listing

Identifying early abdominal obesity risk in adolescents by telemedicine: a cross-sectional study in Greece.

Food Chem Toxicol 2020 Jul 6:111532. Epub 2020 Jul 6.

Center for Adolescent Medicine and UNESCO Chair on Adolescent Health Care, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, 1 Thivon Street, Athens, 11527, Greece. Electronic address:

Obesity and thus, lipotoxicity, is a major health risk factor. Modern exposure to environmental chemicals has contributed significantly to the obesity epidemic. The purpose of this study was to assess, via telemedicine and using bioelectrical impedance analysis (BIA) in schools, the levels of adiposity and other body composition parameters of Greek adolescents in relation with their metabolic syndrome (MetS) characteristics. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111532DOI Listing

The impact of metabolically healthy obesity in primary infertile men: Results from a cross-sectional study.

Andrology 2020 Jul 9. Epub 2020 Jul 9.

University Vita-Salute San Raffaele, Milan, Italy.

Background: A number of studies showed that obesity may negatively impact on sperm quality and consequently couple's fertility. Recently, specific attention was given to a clinical condition known as Metabolically Healthy Obesity (MHO).

Objectives: To evaluate the effects of MHO on semen and hormonal parameters of men presenting for primary couple's infertility associated with pure male factor infertility (MFI). Read More

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http://dx.doi.org/10.1111/andr.12861DOI Listing

Early-stage predictors of the acute phase duration in uncomplicated COVID-19 pneumonia.

J Med Virol 2020 Jul 9. Epub 2020 Jul 9.

Metabolic Diseases Unit, Department of Clinical and Experimental Medicine, "Magna Graecia" University, Viale Europa, 88100, Catanzaro, Italy.

Objective: In this study, we aimed to highlight the common early-stage clinical and laboratory variables independently related to the acute phase duration in patients with uncomplicated coronavirus disease (COVID-19) pneumonia.

Methods: In hospitalized patients, the acute phase disease duration was followed using the Brescia-COVID respiratory severity scale (BCRSS). Noninvasive ventilation was administered based on clinical judgment. Read More

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http://dx.doi.org/10.1002/jmv.26281DOI Listing

Association of Major Food Sources of Fructose-Containing Sugars With Incident Metabolic Syndrome: A Systematic Review and Meta-analysis.

JAMA Netw Open 2020 Jul 1;3(7):e209993. Epub 2020 Jul 1.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Importance: Sugar-sweetened beverages (SSBs) are associated with increased risk of metabolic syndrome (MetS). However, the role of other important food sources of fructose-containing sugars in the development of MetS remains unclear.

Objective: To examine the association of major food sources of fructose-containing sugars with incident MetS. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.9993DOI Listing

Current Intake and Demographic Disparities in the Association of Fructose-Rich Foods and Metabolic Syndrome.

JAMA Netw Open 2020 Jul 1;3(7):e2010224. Epub 2020 Jul 1.

Department of Nutrition and Food Studies, Steinhardt School of Culture, Education and Human Development, New York University, New York.

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http://dx.doi.org/10.1001/jamanetworkopen.2020.10224DOI Listing

[Endogenous metabolites involving effects of moxibustion on injured gastric mucosal tissue in rats with stomach heat or cold syndrome based on nuclear magnetic resonance spectroscopy].

Zhen Ci Yan Jiu 2020 Jun;45(6):446-53

Medical College of Xiamen University, Xiamen 361005, Fujian Province.

Objective: To investigate the profile of metabolites of gastric mucosa involving the effectiveness of moxibustion in the treatment of syndromes of stomach heat (SH) and stomach cold (SC) by H-nuclear magnetic resonance (H-NMR) spectroscopy in rats, so as to reveal its mechanisms underlying improvement of gastric disorders.

Methods: Male SD rats were randomly divided into control, SH-model, SC-model, SH-moxibustion and SC-moxibustion groups (=6 rats/group). The SH-model and SC-model were established by gavage of pepper liquid plus ethanol, and ice water plus NaOH, respectively. Read More

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http://dx.doi.org/10.13702/j.1000-0607.190480DOI Listing

Spectrum of Neurological Manifestations in Covid-19: A Review.

Authors:
Ravindra K Garg

Neurol India 2020 May-Jun;68(3):560-572

Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.

COVID-19, in most patients, presents with mild flu-like illness. Elderly patients with comorbidities, like hypertension, diabetes, or lung and cardiac disease, are more likely to have severe disease and deaths. Neurological complications are frequently reported in severely or critically ill patients with comorbidities. Read More

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http://dx.doi.org/10.4103/0028-3886.289000DOI Listing

Metabolic syndrome and female gender, but not methotrexate, are the important associations of significant liver fibrosis in patients with moderate-to-severe psoriasis as detected by transient elastography.

Indian J Dermatol Venereol Leprol 2020 Jul 8. Epub 2020 Jul 8.

Department of Immunopathology, PGIMER, Chandigarh, India.

Background: Many international guidelines on psoriasis management have emphasized upon the need to identify risk factors for liver fibrosis and that the risk may be increased after a certain total cumulative dose of methotrexate.

Methods: Consecutive patients with moderate-to-severe psoriasis were assessed for liver fibrosis using transient elastography and noninvasive scores. Based on the presence of significant liver fibrosis, the Odds ratio associated with various factors was calculated using logistic regression analysis. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_152_19DOI Listing
July 2020
1.325 Impact Factor

Botryosphaeran Attenuates Tumor Development and the Cancer Cachexia Syndrome in Walker-256 Tumor-Bearing Obese Rats and Improves the Metabolic and Hematological Profiles of These Rats.

Nutr Cancer 2020 Jul 8:1-18. Epub 2020 Jul 8.

Núcleo de Pesquisa e Apoio Didático em Saúde (NUPADS), Instituto de Ciências da Saúde, Câmpus Universitário de Sinop, Universidade Federal de Mato Grosso, Sinop, MT, Brazil.

Studies demonstrate that obesity can increase tumor development. Botryosphaeran, a fungal (1→3)(1→6)-β-D-glucan, presents antimutagenic, antiproliferative and pro-apoptotic activities. This study evaluated the effects of botryosphaeran on tumor development and metabolic and hematological parameters in tumor-bearing obese and non-obese rats. Read More

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http://dx.doi.org/10.1080/01635581.2020.1789681DOI Listing

Thyroid hormone levels are associated with metabolic components: a cross-sectional study.

Croat Med J 2020 Jul;61(3):230-238

Tatijana Zemunik, Department of Medical Biology, University of Split School of Medicine,Šoltanska 2, 21000 Split, Croatia,

Aim: To analyze the association of thyroid function and hormone levels with metabolic syndrome (MetS) and its components.

Methods: This cross-sectional population-based study involved 2183 Croatian individuals with no history of thyroid disease, hypertension, diabetes, and hyperlipidemia. MetS was diagnosed according to the National Cholesterol Education Program's Adult Treatment Panel III criteria. Read More

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Perinatal Exposure to Maternal Obesity: Lasting Cardiometabolic Impact on Offspring.

Prenat Diagn 2020 Jul 8. Epub 2020 Jul 8.

Massachusetts General Hospital Research Institute and Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, US.

Evidence from epidemiological, clinical, and animal model studies clearly demonstrates that prenatal and lactational maternal obesity and high-fat diet consumption are associated with cardiometabolic morbidity in offspring. Fetal and offspring sex may be an important effect modifier. Adverse offspring cardiometabolic outcomes observed in the setting of maternal obesity include an increased risk for obesity, features of metabolic syndrome (hypertension, hyperglycemia and insulin resistance, hyperlipidemia, increased adiposity), and non-alcoholic fatty liver disease. Read More

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http://dx.doi.org/10.1002/pd.5784DOI Listing

Intracranial calcifications in childhood: Part 2.

Pediatr Radiol 2020 Jul 8. Epub 2020 Jul 8.

Division of Neuroradiology, Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.

This article is the second of a two-part series on intracranial calcification in childhood. In Part 1, the authors discussed the main differences between physiological and pathological intracranial calcification. They also outlined histological intracranial calcification characteristics and how these can be detected across different neuroimaging modalities. Read More

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http://dx.doi.org/10.1007/s00247-020-04716-yDOI Listing

Minimally Invasive Surfactant Therapy: An Analytical Report of Our Prospective Dubai Cohort.

Cureus 2020 Jun 5;12(6):e8455. Epub 2020 Jun 5.

Neonatology, Medeor Hospital, Dubai, ARE.

Introduction:  Type 2 pneumocytes of the respiratory epithelium secrete the endogenous surfactant, a detergent-like substance that lines the alveolar sacs of the lungs. The surfactant facilitates the gas exchange process across the alveolar membrane by preventing the collapse of the alveoli and thereby maintaining their distended state. Respiratory distress syndrome of the premature neonates is characterized by quantitative and/or qualitative defects of endogenous surfactant metabolic pathways. Read More

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http://dx.doi.org/10.7759/cureus.8455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336671PMC

The effects of aerobic, resistance, and combined exercises on the plasma irisin levels, HOMA-IR, and lipid profiles in women with metabolic syndrome: A randomized controlled trial.

J Exerc Sci Fit 2020 Sep 20;18(3):168-176. Epub 2020 Jun 20.

Department of Nutrition, School of Health, Larestan University of Medical Sciences, Larestan, Iran.

Background/objective: Irisin is suggested to be an exercise beneficial effects mediator. This study aimed to examine the effects of the aerobic exercise (AE), resistance exercise (RE), and combined exercise (CE) on the plasma levels of irisin and some metabolic and anthropometric indices.

Methods: Sixty overweight women with metabolic syndrome were assigned equally into four groups: AE, RE, CE, and control. Read More

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http://dx.doi.org/10.1016/j.jesf.2020.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334615PMC
September 2020

Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate.

Nat Commun 2020 Jul 8;11(1):3412. Epub 2020 Jul 8.

Centre for Inflammation Biology and Cancer Immunology, School of Immunology and Microbial Sciences, King's College London, London, SE1 1UL, UK.

Regulatory B cells restrict immune and inflammatory responses across a number of contexts. This capacity is mediated primarily through the production of IL-10. Here we demonstrate that the induction of a regulatory program in human B cells is dependent on a metabolic priming event driven by cholesterol metabolism. Read More

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http://dx.doi.org/10.1038/s41467-020-17179-4DOI Listing

Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition.

Sci Rep 2020 Jul 8;10(1):11235. Epub 2020 Jul 8.

The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.

HIV infection affects up to 30% of children presenting with severe acute malnutrition (SAM) in Africa and is associated with increased mortality. Children with SAM are treated similarly regardless of HIV status, although mechanisms of nutritional recovery in HIV and/or SAM are not well understood. We performed a secondary analysis of a clinical trial and plasma proteomics data among children with complicated SAM in Kenya and Malawi. Read More

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http://dx.doi.org/10.1038/s41598-020-68143-7DOI Listing

Omeprazole-induced hypomagnesaemia, causing renal tubular acidosis with hypokalaemia, hypocalcaemia, hyperlactacidaemia and hyperammonaemia.

BMJ Case Rep 2020 Jul 8;13(7). Epub 2020 Jul 8.

Department of Internal Medicine, Ako City Hospital, Ako, Hyogo, Japan.

A 72-year-old Japanese man treated with omeprazole for 11 years was admitted due to loss of consciousness and muscle weakness. Wolff-Parkinson-White syndrome-induced tachycardia was considered as the cause of syncope. His blood examination revealed rhabdomyolysis, hypokalaemia, hypomagnesaemia, hypocalcaemia, hyperlactacidaemia, hyperammonaemia and high-anion-gap metabolic acidosis. Read More

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http://dx.doi.org/10.1136/bcr-2020-235385DOI Listing

Lifestyle Modification Practices and Drug Prescription Use in Elderly Americans with Metabolic Syndrome: A Nationwide Population-Based Study.

J Natl Med Assoc 2020 Jul 5. Epub 2020 Jul 5.

Department of Health Policy and Behavioral Sciences, Georgia State School of Public Health, Atlanta, GA, USA; Global Research Against Noncommunicable Diseases (GRAND), Georgia State School of Public Health, Atlanta, USA.

Aim: To determine differences in lifestyle modification practices and use of prescription drugs in a representative sample of Mexican American (MA), non-Hispanic White (NHW), and non-Hispanic Black (NHB) elderly Americans with metabolic syndrome (MetS).

Methods: Data from the United States National Health and Nutritional Examination Surveys were used in this study. Lifestyle modification practices include ongoing physical activity, weight control, and ongoing diet modifications. Read More

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http://dx.doi.org/10.1016/j.jnma.2020.06.008DOI Listing

The association between nutrient patterns and metabolic syndrome among Iranian adults: cross-sectional analysis of Shahedieh cohort study.

Public Health Nutr 2020 Jul 9:1-10. Epub 2020 Jul 9.

Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Objective: To assess the association between patterns of nutrient intake and metabolic syndrome (MetS) in a large sample of Iranian adults.

Design: Baseline data from the Shahedieh cohort study were used in the current cross-sectional study. Dietary intakes were assessed through the use of a validated semi-quantitative FFQ. Read More

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http://dx.doi.org/10.1017/S1368980020001639DOI Listing

Incorporating an Increase in Plant-Based Food Choices into a Model of Culturally Responsive Care for Hispanic/Latino Children and Adults Who Are Overweight/Obese.

Int J Environ Res Public Health 2020 Jul 6;17(13). Epub 2020 Jul 6.

Department of Family Medicine, Adventist Health White Memorial Medical Center, Los Angeles, CA 90033, USA.

The national rate of obesity in US Hispanic/Latinos exceeds all other major ethnic subgroups and represents an important health disparity. Plant-based diet interventions that emphasize whole plant foods with minimal processing and less refined grains and sugar have shown have shown great promise in control of obesity, but there is a paucity of data translating this treatment effect to disparate populations. The objective of our study was to evaluate the efficacy of the Healthy Eating Lifestyle Program (HELP) for accomplishing weight management in a hospital-based, family centered, culturally tailored, plant-based diet intervention for Hispanic/Latino children who were overweight or obese. Read More

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http://dx.doi.org/10.3390/ijerph17134849DOI Listing

COVID-19 and ethnicity: A novel pathophysiological role for inflammation.

Diabetes Metab Syndr 2020 Jun 30;14(5):1043-1051. Epub 2020 Jun 30.

Diabetes Research Centre, University of Leicester, UK.

Introduction: There have been recent mounting concerns regarding multiple reports stating a significantly elevated relative-risk of COVID-19 mortality amongst the Black and Minority Ethnic (BAME) population. An urgent national enquiry investigating the possible reasons for this phenomenon has been issued in the UK. Inflammation is at the forefront of COVID-19 research as disease severity appears to correlate with pro-inflammatory cytokine dysregulation. Read More

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http://dx.doi.org/10.1016/j.dsx.2020.06.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326443PMC

Gonadal Hormones and Stroke Risk: PCOS as a Case Study.

Front Neuroendocrinol 2020 Jul 5:100853. Epub 2020 Jul 5.

Department of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center College of Medicine, Bryan, Texas 77807. Electronic address:

It is well known that stroke incidence and outcome is sex-dependent and influenced by age and gonadal hormones. In post-menopausal and/or aged females, declining estrogen levels increases stroke risk. However, women who experience early menopause also have an increase in stroke risk. Read More

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http://dx.doi.org/10.1016/j.yfrne.2020.100853DOI Listing

Obesity, menstrual irregularity and polycystic ovary syndrome in young women with type 1 diabetes: a population-based study.

Clin Endocrinol (Oxf) 2020 Jul 8. Epub 2020 Jul 8.

Monash Centre for Health Research and Implementation, School of Public Health and Preventative Medicine, Monash University, Clayton, Victoria, Australia.

Background: Type 1 diabetes (T1D) is associated with reproductive dysfunction, particularly in the setting of poor metabolic control. Improvements in contemporary management ameliorates these problems, albeit at the cost of increased exogenous insulin and rising obesity, with emerging reproductive implications.

Objective: To evaluate changes in body mass index (BMI), and the relationship between obesity, menstrual irregularity and polycystic ovary syndrome (PCOS) in young women with T1D, compared with controls. Read More

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http://dx.doi.org/10.1111/cen.14281DOI Listing

Methylenetetrahydrofolate reductase gene polymorphisms in the risk of polycystic ovary syndrome and ovarian cancer.

Biosci Rep 2020 Jul 8. Epub 2020 Jul 8.

West China Second Hospital, Chengdu, China.

Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) in hormone metabolism pathways might cause metabolic disturbances and contribute to the development of polycystic ovary syndrome (PCOS) and ovarian cancer, but the published studies were inconsistent. The aim of this study was to evaluate the MTHFR C677T (rs1801133) and A1298C (rs1801131) gene polymorphisms in the risk of PCOS and ovarian cancer by meta-analysis. A comprehensive electronic search was conducted in databases for studies published from 1995 to 2020. Read More

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http://dx.doi.org/10.1042/BSR20200995DOI Listing

Vortioxetine on Cognition in Schizophrenia: A Pilot Study.

J Clin Psychopharmacol 2020 Jul/Aug;40(4):381-385

From the Departments of Biomedical and Dental Sciences and Morphofunctional Imaging.

Background: Given the wide implications of cognitive impairment for prognosis and outcome in schizophrenia, the research on pharmacological approaches aimed at addressing dysfunctional cognition has been extensive; nevertheless, there are no currently available licensed drugs, and the evidence in this field is still unimpressive. Vortioxetine is a multimodal antidepressant, which has been proposed as a suitable treatment option for cognitive symptoms in depression.

Methods: Twenty schizophrenia outpatients (mean age ± SD, 40. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001242DOI Listing
July 2020
3.243 Impact Factor

Vitamin D levels are not associated with non-alcoholic fatty liver disease severity in a Brazilian population.

Int J Vitam Nutr Res 2020 Jul 8:1-8. Epub 2020 Jul 8.

Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. Read More

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http://dx.doi.org/10.1024/0300-9831/a000667DOI Listing

Comorbidities in Older Persons with Controlled HIV Infection: Correlations with Frailty Index Subtypes.

AIDS Patient Care STDS 2020 Jul;34(7):284-294

Department of Neurology and Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Frailty is prevalent in persons with human immunodeficiency virus (PWH), but factors predisposing older PWH to frailty remain uncertain. We examined factors associated with frailty and determined whether there were multiple frailty subtypes in older adults with controlled HIV infection. This was a cross-sectional outpatient study in an urban HIV clinic. Read More

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http://dx.doi.org/10.1089/apc.2020.0051DOI Listing

Level of leisure-time physical activity and its association with the prevalence of metabolic syndrome in adults: a population-based study.

Rev Bras Epidemiol 2020 6;23:e200070. Epub 2020 Jul 6.

Discipline of General Practice Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.

Objective: To analyze the associations between changes in the level of leisure-time physical activity in adults and the prevalence of metabolic syndrome.

Methods: This is a population-based study conducted with 818 adults aged 20 years or older from Florianópolis, Santa Catarina, Southern Brazil, between 2009 and 2014. We tested the association of maintenance and/or changes in the level of physical activity with the prevalence of metabolic syndrome, adjusted for sociodemographic variables (gender, age, schooling, income, marital status, and ethnicity) and smoking habits. Read More

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http://dx.doi.org/10.1590/1980-549720200070DOI Listing

Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways.

Med Sci Monit 2020 Jul 8;26:e923073. Epub 2020 Jul 8.

College of Acupuncture, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China (mainland).

BACKGROUND The aim of this study was to explore whether letrozole and high-fat diets (HFD) can induce obese insulin-resistant polycystic ovary syndrome (PCOS) with all reproductive and metabolic phenotypes in a rat model. MATERIAL AND METHODS Twenty-four 3-week-old female Sprague-Dawley rats were randomized into 4 groups: control, Letrozole, HFD, and Letrozol+HFD. The PCOS model was induced by 12 weeks of Letrozole treatment (1 mg/kg p. Read More

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http://dx.doi.org/10.12659/MSM.923073DOI Listing

Wide QRS-T angles are associated with markers of increased inflammatory activity independently of hypertension and diabetes.

Ann Noninvasive Electrocardiol 2020 Jul 8:e12781. Epub 2020 Jul 8.

Region Västra Götaland, Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden.

Background: Wide QRS-T angles and inflammatory activity are markers of future cardiovascular events including sudden cardiac death (SCD). The association between wide QRS-T angles and inflammatory activation is however not fully understood.

Methods: 1,094 study participants of both sexes, 50-64 years old, were included from a randomly selected population-based cohort as a part of the Swedish CArdioPulmonary bioImage Study (SCAPIS) pilot study. Read More

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http://dx.doi.org/10.1111/anec.12781DOI Listing

Invasive liver abscess syndrome accompanied by spondylodiscitis: a case report and review of the literature.

Clin J Gastroenterol 2020 Jul 7. Epub 2020 Jul 7.

Department of Internal Medicine, Nagano Prefectural Kiso Hospital, Kiso, Japan.

A 65-year-old man who had diabetes mellitus was referred to our hospital due to fever and back pain. Laboratory findings showed liver dysfunction and C-reactive protein (CRP) elevation. Enhanced computed tomography (CT) showed multiple liver abscesses, hepatic vein and inferior vena cava thrombosis, and spondylodiscitis in the fourth lumbar vertebrae. Read More

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http://dx.doi.org/10.1007/s12328-020-01161-0DOI Listing

The metabolic performance predicts home range size of bank voles: a support for the behavioral-bioenergetics theory.

Oecologia 2020 Jul 7. Epub 2020 Jul 7.

Institute of Environmental Sciences, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland.

The pace-of-life syndrome describes covariation between life-history, behavioral and physiological traits; while, the emerging behavioral-bioenergetics theory proposes mechanistic links between those traits in a spatial-ecological context. However, little is known about the association between the limits to metabolic rate and spatial performance (i.e. Read More

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http://dx.doi.org/10.1007/s00442-020-04704-xDOI Listing

Protein intake and osteosarcopenic adiposity in Korean adults aged 50 years and older.

Authors:
M-K Choi Y-J Bae

Osteoporos Int 2020 Jul 8. Epub 2020 Jul 8.

Division of Food Science and Biotechnology, Korea National University of Transportation, Jeungpyeong, South Korea.

Intake of plant-based protein and recommended protein intake are associated with a lower risk of osteosarcopenic adiposity (co-occurrence of osteopenia/osteoporosis, sarcopenia, and adiposity) in elderly Korean men.

Introduction: Osteosarcopenic adiposity (OSA) syndrome is defined as the concurrent presence of osteopenia/osteoporosis, sarcopenia, and adiposity and leads to negative functional and metabolic outcomes in late adulthood. This study aimed to investigate the association between OSA and protein intake in adults aged 50 or older. Read More

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http://dx.doi.org/10.1007/s00198-020-05529-3DOI Listing

Health benefits of xylitol.

Appl Microbiol Biotechnol 2020 Jul 7. Epub 2020 Jul 7.

Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo i Rana, Norway.

Many diseases, including caries, chronic inflammatory diseases, diabetes, and obesity, are associated with uncontrolled sugar consumption. Artificial sweeteners are commonly used in food and pharmaceutical industries as sugar substitutes for the prevention of several dental and body diseases; they also have a favorable impact on body weight as they may help to restrict simple sugar consumption. Xylitol is a sugar alcohol that is commonly used as a sweetener. Read More

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http://dx.doi.org/10.1007/s00253-020-10708-7DOI Listing

Blau Syndrome and Early-Onset Sarcoidosis: A Six Case Series and Review of the Literature.

Arch Rheumatol 2020 Mar 6;35(1):117-127. Epub 2019 Nov 6.

Division of Pediatric Rheumatology, Erciyes University Faculty of Medicine, Kayseri, Turkey.

Objectives: This study aims to discuss the clinical, laboratory and genetic findings, and treatment options for six patients who were diagnosed with Blau syndrome (BS)/early-onset sarcoidosis (EOS).

Patients And Methods: The study included four patients (2 males,2 females; mean age 7 years; range 4 to 10 years) with EOS and two siblings (1 male, 1 female; mean age 10 years; range, 9 to 11 years) with BS. Age, age of initial symptoms, age of diagnosis; articular involvement, presence of uveitis, dermatitis, or fever, other organ involvement, laboratory findings, results of metabolic tests for mucopolysaccharidosis and mucolipidosis, results of genetic, pathologic, and immunologic tests, radiologic findings to evaluate skeletal dysplasia, and treatment options were collected. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2020.7060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322314PMC

Maternal and neonatal outcomes among pregnant women with different polycystic ovary syndrome phenotypes: A cross-sectional study.

Int J Reprod Biomed (Yazd) 2020 May 31;18(5):339-346. Epub 2020 May 31.

Shahid Sadougui Hospital, Shahid Sadougui University of Medical Sciences, and Health Services, Yazd, Iran.

Background: Pregnancy is a process associated with various metabolic and hormonal changes, and polycystic ovary syndrome (PCOS) can affect this process.

Objective: This study aimed to evaluate and compare the maternal and neonatal outcomes among pregnant women with different polycystic ovary syndrome phenotypes.

Materials And Methods: In this cross-sectional study, 200 pregnant women with PCOS according to the 2003 ESHRE/ASRM criteria were categorized into four phenotype groups (A-D). Read More

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http://dx.doi.org/10.18502/ijrm.v13i5.7154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306059PMC