2,968 results match your criteria Metabolic Neuropathy


Can we link foot ulcer with risk factors in diabetics? A study in a tertiary care hospital.

Pak J Med Sci 2018 Nov-Dec;34(6):1375-1380

Zohaib Abbas Khan, Director technical (Add), Drug Testing Laboratory, Punjab, Rawalpindi.

Objective: Although many studies worldwide explained the risk factors for developing Diabetic Foot Ulceration (DFU), little has been done to assess medical factors in DFU formation and link them in patients of Pakistan. This study aimed to link the DFU with different risk factors.

Methods: This descriptive cross-sectional retrospective study was conducted in Diabetes Endocrine and Metabolic Centre / Post Graduate Medical Institute / Lahore General Hospital. Read More

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http://dx.doi.org/10.12669/pjms.346.16199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290204PMC
December 2018

Peripheral nervous system involvement in lymphomas.

J Peripher Nerv Syst 2018 Dec 16. Epub 2018 Dec 16.

Hematology and Clinical Immunology Unit, Department of Medicine, University of Padova, Padova.

The peripheral nervous system may be involved at any stage in the course of lymphoproliferative diseases. The different underlying mechanisms include neurotoxicity secondary to chemotherapy, direct nerve infiltration (neurolymphomatosis), infections, immune-mediated, paraneoplastic or metabolic processes and nutritional deficiencies. Accordingly, the clinical features are heterogeneous and depend on the localization of the damage (ganglia, roots, plexi, peripheral nerves) and on the involved structures (myelin, axon, cell body). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jns.12295
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http://dx.doi.org/10.1111/jns.12295DOI Listing
December 2018
1 Read

Genetic variants in DNMT1 and the risk of cardiac autonomic neuropathy in females with Type 1 diabetes.

J Diabetes Investig 2018 Dec 11. Epub 2018 Dec 11.

Laboratório de Carboidratos e Radioimunoensaio LIM-18, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR. Av. Dr. Arnaldo, 455São Paulo, SP, BR.

Aims/introduction: Epigenetics participate in the pathogenesis of metabolic memory, a situation in which hyperglycemia exerts prolonged deleterious effects even after its normalization. We tested the hypothesis that genetic variants in an epigenetic gene could predispose to diabetes complications.

Material And Methods: We assessed the frequency of 5 single nucleotide polymorphisms (SNPs) in the gene encoding DNA methytransferase 1 (DNMT1; rs8112895, rs7254567, rs11085721, rs17291414, and rs10854076) and their associations with diabetic kidney disease, retinopathy, distal polyneuropathy and autonomic cardiovascular neuropathy (CAN) in 359 long-term Type 1 diabetes individuals. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdi.12988
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http://dx.doi.org/10.1111/jdi.12988DOI Listing
December 2018
1 Read

Late adult-onset adrenomyeloneuropathy evolving with atypical severe frontal lobe syndrome: Importance of neuroimaging.

Radiol Case Rep 2019 Mar 5;14(3):309-314. Epub 2018 Dec 5.

Department of Medical, Surgical, Neurological, Metabolic Sciences, and Aging, 2nd Division of Neurology, Center for Rare Diseases and InterUniversity Center for Research in Neurosciences, University of Campania "Luigi Vanvitelli", Via Sergio Pansini, 80131 Naples, Italy.

X-linked adrenoleukodystrophy (X-ALD) is a rare inherited metabolic disease affecting the nervous system and the adrenal glands. It is caused by a mutation of the gene, resulting in the impaired degradation of very long-chain fatty acids and their subsequent accumulation in several organs and tissues. X-ALD is notable for its high phenotypical variability, that includes isolated adrenocortical insufficiency, slowly progressive myelopathy with paraparesis, ataxia, and peripheral neuropathy to severe childhood cerebral forms. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282458PMC

Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications.

J Diabetes Res 2018 12;2018:5205126. Epub 2018 Nov 12.

Department of Internal Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.

The prevalence of diabetes is steadily rising, and once it occurs, it can cause multiple complications with a negative impact on the whole organism. Complications of diabetes may be macrovascular: such as stroke and ischemic heart disease as well as peripheral vascular and microvascular diseases-retinopathy, nephropathy, and neuropathy. Key factors that cause cardiovascular disease in people with diabetes include hyperglycemia, dyslipidemia, obesity, insulin resistance, inflammation, hypertension, autonomic dysfunction, and decreased vascular response capacity. Read More

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http://dx.doi.org/10.1155/2018/5205126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260408PMC
November 2018
1 Read

The LKB1-AMPK and mTORC1 Metabolic Signaling Networks in Schwann Cells Control Axon Integrity and Myelination: Assembling and upholding nerves by metabolic signaling in Schwann cells.

Authors:
Bogdan Beirowski

Bioessays 2018 Dec 11:e1800075. Epub 2018 Dec 11.

Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, 14203, USA.

The Liver kinase B1 with its downstream target AMP activated protein kinase (LKB1-AMPK), and the key nutrient sensor mammalian target of rapamycin complex 1 (mTORC1) form two signaling systems that coordinate metabolic and cellular activity with changes in the environment in order to preserve homeostasis. For example, nutritional fluctuations rapidly feed back on these signaling systems and thereby affect cell-specific functions. Recent studies have started to reveal important roles of these strategic metabolic regulators in Schwann cells for the trophic support and myelination of axons. Read More

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http://dx.doi.org/10.1002/bies.201800075DOI Listing
December 2018

Giant Axonal Neuropathy: Clinical, Radiological, and Genetic Features.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):304-308

Department of Pediatric Neurosciences, Bai Jerbai Wadia Hospital for Children, Mumbai, India.

Introduction: Giant axonal neuropathy (GAN) is an inherited neurodegenerative disorder caused by mutations in the GAN gene. It affects both the central and peripheral nervous systems. We discuss clinical, electrophysiological, radiological and genetic features in three new unrelated patients with GAN. Read More

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http://dx.doi.org/10.4103/aian.AIAN_82_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238561PMC
December 2018
1 Read

Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice.

PLoS One 2018 10;13(12):e0208596. Epub 2018 Dec 10.

National Research Council-CNR, Institute of Cell Biology and Neurobiology, Rome, Italy.

There is a growing interest on the role of autophagy in diabetes pathophysiology, where development of neuropathy is one of the most frequent comorbidities. We have previously demonstrated that neuropathic pain after nerve damage is exacerbated in autophagy-defective heterozygous Ambra1 mice. Here, we show the existence of a prediabetic state in Ambra1 mice, characterized by hyperglycemia, intolerance to glucose and insulin resistance. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208596PLOS
December 2018
1 Read

Cobalamin (Vitamin B12) Induced a Shift in Microbial Composition and Metabolic Activity in an Colon Simulation.

Front Microbiol 2018 16;9:2780. Epub 2018 Nov 16.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, China.

Cobalamin deficiency is believed to be related to disturbances in cell division, neuropathy, nervous system disease and pernicious anemia. Elderly people are usually advised to supplement their diets with cobalamin. As cobalamin has several forms, the effects of different forms of cobalamin on gut microbiota were investigated in this study. Read More

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http://dx.doi.org/10.3389/fmicb.2018.02780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250798PMC
November 2018
1 Read

Discovery and evaluation of novel FAAH inhibitors in neuropathic pain model.

Bioorg Med Chem Lett 2018 Nov 24. Epub 2018 Nov 24.

Drug Discovery Facility - Pune, Advinus Therapeutics Limited, Head Office: Block No. 21 & 22, Phase II, Peenya Industrial Area, Bangalore 560058, India.

Conceptual design and modification of urea moiety in chemotype PF-3845/04457845, the bench marking irreversible inhibitor of fatty acid amide hydrolase (FAAH), led to discovery of a novel nicotinamide-based lead 12a having reversible mechanism of action. Focused SAR around the pyridine heterocycle (Ar) in 12a (Tables 1 and 2) resulted into four shortlisted compounds, (-)-12a, (-)-12i, (-)-12l-m. The required (-)-enantiomers were obtained via diastereomeric resolution of a novel chiral dissymmetric intermediate 15. Read More

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http://dx.doi.org/10.1016/j.bmcl.2018.11.048DOI Listing
November 2018

Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: Presentations, causes and treatment strategies.

Authors:
Sherifa A Hamed

Expert Rev Clin Pharmacol 2018 Dec 2. Epub 2018 Dec 2.

a Department of Neurology and Psychiatry , Assiut University Hospital , Assiut , Egypt.

Introduction: Uremic syndrome of chronic kidney disease (CKD) is a term used to describe clinical, metabolic and hormonal abnormalities associated with progressive kidney failure. It is a rapidly growing public health problem worldwide. Nervous system complications occur in every patient with uremic syndrome of CKD. Read More

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http://dx.doi.org/10.1080/17512433.2019.1555468DOI Listing
December 2018
1 Read

SIV-Induced Immune Activation and Metabolic Alterations in the Dorsal Root Ganglia During Acute Infection.

J Neuropathol Exp Neurol 2019 Jan;78(1):78-87

Department of Molecular and Comparative Pathobiology.

Human immunodeficiency virus-associated sensory neuropathy (HIV-SN) remains a frequent neurologic complication of HIV infection. Little is known about alterations in the peripheral nervous system during the early stages of HIV, a time when neuroprotective interventions may be most beneficial. We performed Nanostring gene expression analysis on lumbar dorsal root ganglia (DRG) from 6 simian immunodeficiency virus (SIV)-infected pigtailed macaques killed at 7 days post-inoculation and 8 uninfected controls. Read More

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http://dx.doi.org/10.1093/jnen/nly111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289222PMC
January 2019

Peripheral nerve disease.

Authors:
Gita Ramdharry

Handb Clin Neurol 2018 ;159:403-415

Faculty of Health, Social Care and Education, Kingston University and Queen Square MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, United Kingdom. Electronic address:

Polyneuropathies are common neurologic disorders affecting the peripheral nerves. There are a number of causes of damage to these structures, such as genetic and metabolic factors, autoimmune disorders, infection, drug or environmental toxicity, and malignancy. Motor and sensory impairments are commonly encountered in these conditions, leading to altered balance and gait with increased risk of falling. Read More

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http://dx.doi.org/10.1016/B978-0-444-63916-5.00026-4DOI Listing
January 2018

Calcimimetic restores diabetic peripheral neuropathy by ameliorating apoptosis and improving autophagy.

Cell Death Dis 2018 Nov 26;9(12):1163. Epub 2018 Nov 26.

Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Decreased AMPK-eNOS bioavailability mediates the development of diabetic peripheral neuropathy (DPN) through increased apoptosis and decreased autophagy activity in relation to oxidative stress. Schwann cells are responsible for maintaining structural and functional integrity of neurons and for repairing damaged nerves. We evaluated the neuro-protective effect of cinacalcet on DPN by activating the AMPK-eNOS pathway using db/db mice and human Schwann cells (HSCs). Read More

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http://www.nature.com/articles/s41419-018-1192-7
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http://dx.doi.org/10.1038/s41419-018-1192-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255917PMC
November 2018
4 Reads

Vertical displacement of the centre of mass during walking in people with diabetes and diabetic neuropathy does not explain their higher metabolic cost of walking.

J Biomech 2018 Nov 20. Epub 2018 Nov 20.

Research Centre for Musculoskeletal Science & Sports Medicine, School of Healthcare Science, Faculty of Science & Engineering, Manchester Metropolitan University, UK. Electronic address:

People with diabetes display biomechanical gait alterations compared to controls and have a higher metabolic cost of walking (CoW), but it remains unknown whether differences in the vertical displacement of the body centre of mass (CoM) may play a role in this higher CoW. The aim of this study was to investigate vertical CoM displacement (and step length as a potential underpinning factor) as an explanatory factor in the previously observed increased CoW with diabetes. Thirty-one non-diabetic controls (Ctrl); 22 diabetic patients without peripheral neuropathy (DM) and 14 patients with moderate/severe Diabetic Peripheral Neuropathy (DPN), underwent gait analysis using a motion analysis system and force plates while walking at a range of matched speeds between 0. Read More

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http://dx.doi.org/10.1016/j.jbiomech.2018.11.027DOI Listing
November 2018
1 Read

0.075% capsaicin lotion for the treatment of painful diabetic neuropathy: A randomized, double-blind, crossover, placebo-controlled trial.

J Clin Neurosci 2018 Nov 21. Epub 2018 Nov 21.

Center of Excellence for Diabetic Foot Care, Thammasat University Hospital, Pathumthani, Thailand; Department of Nursing, Thammasat University Hospital, Pathumthani, Thailand.

Objective: A randomized, double-blinded, crossover, placebo controlled trial was conducted to evaluate the efficacy and safety of 0.075% capsaicin lotion for treating painful diabetic neuropathy (PDN).

Patients And Methods: PDN subjects were randomized to receive 0. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.11.036DOI Listing
November 2018
2 Reads

Emerging role of Unfolded Protein Response (UPR) mediated proteotoxic apoptosis in diabetes.

Life Sci 2019 Jan 22;216:246-258. Epub 2018 Nov 22.

Herbal Research Laboratory, Food, Drug & Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan 31, M.G Marg, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Toxicology Research, Lucknow 226001, Uttar Pradesh, India. Electronic address:

Endoplasmic reticulum (ER) is a crucial single membrane organelle that acts as a quality control system for cellular proteins as it is intricately involved in their synthesis, folding and trafficking to the respective targets. Type 2 diabetes is characterized by enhanced blood glucose level that promotes insulin resistance and hampers cellular glucose metabolism. Hyperglycemia provokes mitochondrial ROS production and glycation of proteins which exert a tremendous load on ER for conventional refolding of misfolded/unfolded and nascent proteins that perturb ER homeostasis resulting in apoptotic cell death. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.11.041DOI Listing
January 2019
4 Reads

Modeling Diabetic Corneal Neuropathy in a 3D In Vitro Cornea System.

Sci Rep 2018 Nov 23;8(1):17294. Epub 2018 Nov 23.

Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.

Diabetes mellitus is a disease caused by innate or acquired insulin deficiency, resulting in altered glucose metabolism and high blood glucose levels. Chronic hyperglycemia is linked to development of several ocular pathologies affecting the anterior segment, including diabetic corneal neuropathy and keratopathy, neovascular glaucoma, edema, and cataracts leading to significant visual defects. Due to increasing disease prevalence, related medical care costs, and visual impairment resulting from diabetes, a need has arisen to devise alternative systems to study molecular mechanisms involved in disease onset and progression. Read More

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http://dx.doi.org/10.1038/s41598-018-35917-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251923PMC
November 2018
11 Reads

Madelung Disease: Analysis of Clinicopathological Experience in Taipei Veterans General Hospital.

Ann Plast Surg 2019 Jan;82(1S Suppl 1):S66-S71

From the Division of Plastic Surgery, Department of Surgery, and.

Background: The main feature of Madelung disease (MD), a rare condition, is the growth of adipose tissue without a capsule. Usually, this disease is known for its prominent features with fat deposition around the neck, shoulder, back, or chest wall. Clinically, the patient is likely to exhibit alcohol, neuropathy, and metabolic disorders; however, no clear cause has been confirmed. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001719DOI Listing
January 2019
4 Reads

A Case of Fulminant Type 1 Diabetes with Gastric and Urinary Retention.

Diabetes Ther 2018 Nov 20. Epub 2018 Nov 20.

First Endocrinology Department, Shengjing Hospital Affiliated to China Medical University, Shenyang, People's Republic of China.

Fulminant type 1 diabetes (fT1D) is a severe subtype of type 1 diabetes which progresses rapidly with islet cells destroyed almost completely within a short period of time. It is often characterized by flu-like or gastrointestinal symptoms at the onset with negative islet-associated autoantibodies, resulting in an absolute deficiency of endogenous insulin secretion. Poor prognosis can be caused by the significantly higher incidence of metabolic disorders (such as severe ion disorders and elevated serum pancreatic enzymes), acute and chronic complications if not diagnosed and treated in a timely manner. Read More

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http://dx.doi.org/10.1007/s13300-018-0533-yDOI Listing
November 2018
3 Reads

POLG-related disorders and their neurological manifestations.

Nat Rev Neurol 2018 Nov 19. Epub 2018 Nov 19.

Mitochondrial DNA Replication Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Durham, NC, USA.

The POLG gene encodes the mitochondrial DNA polymerase that is responsible for replication of the mitochondrial genome. Mutations in POLG can cause early childhood mitochondrial DNA (mtDNA) depletion syndromes or later-onset syndromes arising from mtDNA deletions. POLG mutations are the most common cause of inherited mitochondrial disorders, with as many as 2% of the population carrying these mutations. Read More

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http://www.nature.com/articles/s41582-018-0101-0
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http://dx.doi.org/10.1038/s41582-018-0101-0DOI Listing
November 2018
3 Reads

Surgical options for meralgia paresthetica: long-term outcomes in 13 cases.

Br J Neurosurg 2018 Nov 19:1-4. Epub 2018 Nov 19.

c Department of Neurosurgery , Eskisehir State Hospital , Eskisehir , Turkey.

Background: Meralgia paresthetica is an entrapment neuropathy of the lateral femoral cutaneous nerve that may cause paresthesias, pain, and sensory loss of the anterior and lateral thigh. Treatment is primarily medical. Surgery is an option for patients who do not respond to medical treatments. Read More

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https://www.tandfonline.com/doi/full/10.1080/02688697.2018.1
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http://dx.doi.org/10.1080/02688697.2018.1538480DOI Listing
November 2018
11 Reads
0.950 Impact Factor

All roads lead to glaucoma: Induced retinal injury cascades contribute to a common neurodegenerative outcome.

Exp Eye Res 2018 Nov 14. Epub 2018 Nov 14.

Department of Vision Science, Krembil Research Institute, University Health Network, Toronto, ON, Canada; Vision Science Research Program, Ophthalmology and Vision Science, University of Toronto, Toronto, ON, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

Glaucoma describes a distinct optic neuropathy with complex etiology and a variety of associated risk factors, but with similar pathological endpoints. Risk factors such as age, increased intraocular pressure (IOP), low mean arterial pressure, and autoimmune disease, can all be associated with death of retinal ganglion cells (RGCs) and optic nerve head remodeling. Today, IOP management remains the standard of care, even though IOP elevation is not pathognomonic of glaucoma, and patients can continue to lose vision despite effective IOP control. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144835183037
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http://dx.doi.org/10.1016/j.exer.2018.11.005DOI Listing
November 2018
2 Reads

Differences in skin blood flow oscillations between the plantar and dorsal foot in people with diabetes mellitus and peripheral neuropathy.

Microvasc Res 2019 Mar 9;122:45-51. Epub 2018 Nov 9.

Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, MD, USA.

Background: Understanding the differences in skin blood flow (SBF) on the plantar and dorsal foot in people with diabetes mellitus (DM) may help to assess the influence of diabetes and neuropathy on microvascular dysfunction and risks of diabetic foot ulcers in this population. However, there is no study comparing SBF oscillations between the plantar and dorsal foot in people with DM and peripheral neuropathy (PN).

Objective: The objective of this study was to compare SBF oscillations between the plantar and dorsal foot in people with DM and PN and investigate the underlying mechanisms responsible for the differences. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00262862183012
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http://dx.doi.org/10.1016/j.mvr.2018.11.002DOI Listing
March 2019
7 Reads
2.130 Impact Factor

Linezolid Inhibited Synthesis of ATP in Mitochondria: Based on GC-MS Metabolomics and HPLC Method.

Biomed Res Int 2018 16;2018:3128270. Epub 2018 Oct 16.

Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Linezolid has been widely used in serious infections for its effective inhibiting effect against multidrug-resistant gram-positive pathogens. However, linezolid caused severe adverse reactions, such as thrombocytopenia, anaemia, optic neuropathy, and near-fatal serotonin syndrome. In order to investigate the toxicity of linezolid, twenty-four Sprague-Dawley rats were randomly divided into: control group (n=7), low-group (n=8), and high-group (n=9). Read More

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https://www.hindawi.com/journals/bmri/2018/3128270/
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http://dx.doi.org/10.1155/2018/3128270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206563PMC
October 2018
3 Reads

Co-occurrence of early diabetes-related complications in adolescents and young adults with type 1 diabetes: an observational cohort study.

Lancet Child Adolesc Health 2019 Jan 6;3(1):35-43. Epub 2018 Nov 6.

Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA.

Background: One in three adolescents and young adults with type 1 diabetes have at least one early diabetes-related complication or comorbidity. We aimed to examine the prevalence and pattern of co-occurring complications in this population, as well as the related risk factors.

Methods: This observational cohort study includes data from individuals diagnosed with type 1 diabetes before age 20 years who participated in the SEARCH for Diabetes in Youth Study across five sites in the USA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23524642183030
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http://dx.doi.org/10.1016/S2352-4642(18)30309-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295346PMC
January 2019
10 Reads

Diabetes and Alzheimer's Disease: Mechanisms and Nutritional Aspects.

Clin Nutr Res 2018 Oct 23;7(4):229-240. Epub 2018 Oct 23.

Department of Food and Nutrition, Seoul Women's University, Seoul 01797, Korea.

Blood glucose homeostasis is well maintained by coordinated control of various hormones including insulin and glucagon as well as cytokines under normal conditions. However, chronic exposure to diabetic environment with high fat/high sugar diets and physical/mental stress can cause hyperglycemia, one of main characteristics of insulin resistance, metabolic syndrome, and diabetes. Hyperglycemia impairs organogenesis and induces organ abnormalities such as cardiac defect . Read More

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http://dx.doi.org/10.7762/cnr.2018.7.4.229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209735PMC
October 2018
8 Reads

Bi-allelic ADPRHL2 Mutations Cause Neurodegeneration with Developmental Delay, Ataxia, and Axonal Neuropathy.

Am J Hum Genet 2018 Nov 25;103(5):817-825. Epub 2018 Oct 25.

Institute of Human Genetics, Technische Universität München, 81675 Munich, Germany; Institute of Medical Genetics and Applied Genomics, University of Tuebingen, 72076 Tübingen, Germany; Centre for Rare Diseases, University of Tuebingen, 72076 Tübingen, Germany. Electronic address:

ADP-ribosylation is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases transfer ADP-ribose from NAD to the target protein, and ADP-ribosylhydrolases, such as ADPRHL2, reverse the reaction. We used exome sequencing to identify five different bi-allelic pathogenic ADPRHL2 variants in 12 individuals from 8 families affected by a neurodegenerative disorder manifesting in childhood or adolescence with key clinical features including developmental delay or regression, seizures, ataxia, and axonal (sensori-)motor neuropathy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183035
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http://dx.doi.org/10.1016/j.ajhg.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218634PMC
November 2018
8 Reads

Patterns of Nerve Conduction Abnormalities in Patients with Type 2 Diabetes Mellitus According to the Clinical Phenotype Determined by the Current Perception Threshold.

Diabetes Metab J 2018 Oct 24. Epub 2018 Oct 24.

Department of Internal Medicine, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.

Background: Clinical manifestations of diabetic peripheral neuropathy (DPN) vary along the course of nerve damage. Nerve conduction studies (NCS) have been suggested as a way to confirm diagnoses of DPN, but the results have limited utility for evaluating clinical phenotypes. The current perception threshold (CPT) is a complementary method for diagnosing DPN and assessing DPN symptoms. Read More

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https://e-dmj.org/DOIx.php?id=10.4093/dmj.2018.0068
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http://dx.doi.org/10.4093/dmj.2018.0068DOI Listing
October 2018
6 Reads

Proteomic approach for understanding milder neurotoxicity of Carfilzomib against Bortezomib.

Sci Rep 2018 Nov 5;8(1):16318. Epub 2018 Nov 5.

Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558, Nuthetal, Germany.

The proteasomal system is responsible for the turnover of damaged proteins. Because of its important functions in oncogenesis, inhibiting the proteasomal system is a promising therapeutic approach for cancer treatment. Bortezomib (BTZ) is the first proteasome inhibitor approved by FDA for clinical applications. Read More

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http://www.nature.com/articles/s41598-018-34507-3
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http://dx.doi.org/10.1038/s41598-018-34507-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218500PMC
November 2018
3 Reads

Cardiovascular Autonomic Neuropathy as a New Complication of Postsurgical Chronic Hypoparathyroidism.

J Bone Miner Res 2018 Nov 5. Epub 2018 Nov 5.

Unit of Endocrinology and Diabetes, University Campus Bio-Medico, Rome, Italy.

Postsurgical hypoparathyroidism (hypoPT) increases fatigue and seems to affect the risk of mortality. Cardiovascular autonomic neuropathy (CAN) is an impairment of the cardiovascular autonomic system, a cause of increased mortality, and associated with increased fatigability. The aim of this study is to evaluate CAN in hypoPT and its relationship with hypocalcemia, PTH levels, and hyperphosphatemia. Read More

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http://doi.wiley.com/10.1002/jbmr.3623
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http://dx.doi.org/10.1002/jbmr.3623DOI Listing
November 2018
3 Reads

Regulatory Mechanisms of the Wnt/β-Catenin Pathway in Diabetic Cutaneous Ulcers.

Front Pharmacol 2018 17;9:1114. Epub 2018 Oct 17.

Pharmacy Department, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Skin ulcers are a serious complication of diabetes. Diabetic patients suffer from vascular lesions and complications such as peripheral neuritis, peripheral vascular lesions, and collagen abnormalities, which result in skin wounds that are refractory and often develop into chronic ulcers. The healing of skin ulcers requires an inflammatory reaction, wound proliferation, remodeling regulation, and control of stem cells. Read More

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https://www.frontiersin.org/article/10.3389/fphar.2018.01114
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http://dx.doi.org/10.3389/fphar.2018.01114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199358PMC
October 2018
2 Reads

Soft Tissue Infections in Diabetic Patients.

Chirurgia (Bucur) 2018 Sept-Oct;113(5):651-667

the patient with diabetes has an increased susceptibility to infections, with negative evolutionary potential leading to increased morbidity and mortality compared to the general population. The cause is the alteration of immune defense mechanisms, the hyperglycemic environment leading to alteration of neutrophil function, suppression of the antioxidant system and humoral activity, systemic micro and macroangiopathy, neuropathy, depression of antibacterial activity of the genitourinary and digestive tract. Infections localized at the soft tissue (skin, fascia and aponeurosis, subcutaneous tissue, muscles) in the diabetic patient require a complex medico-surgical approach in which aggressive surgical treatment should be complemented by metabolic balancing and sustained antibiotic therapy. Read More

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http://www.revistachirurgia.ro/pdfs/2018-5-651.pdf
Publisher Site
http://dx.doi.org/10.21614/chirurgia.113.5.651DOI Listing
October 2018
5 Reads

Successful treatment of a genetic childhood ataxia due to riboflavin transporter deficiency.

Cerebellum Ataxias 2018 20;5:12. Epub 2018 Oct 20.

1Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 USA.

Background: Riboflavin transporter deficiency (Brown-Vialetto-Van Laere syndrome) is a rare recessive neurodegenerative disorder that can present with gait ataxia, primarily due to sensory neuropathy as well as cerebellar involvement. Although sensorineural hearing loss, bulbar palsy, and optic atrophy are typical, presentation may be variable and an atypical condition may be difficult to recognize clinically.

Case Presentation: Here we report a patient presenting at age 8 with progressive ataxia since the age of 2. Read More

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https://cerebellumandataxias.biomedcentral.com/articles/10.1
Publisher Site
http://dx.doi.org/10.1186/s40673-018-0091-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196015PMC
October 2018
6 Reads

Modeling WWOX Loss of Function : What Have We Learned?

Front Oncol 2018 10;8:420. Epub 2018 Oct 10.

Faculty of Medicine, The Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research, Israel-Canada (IMRIC), Hebrew University of Jerusalem, Jerusalem, Israel.

The WW domain-containing oxidoreductase ( gene encompasses a common fragile sites (CFS) known as , and is implicated in cancer. encodes a 46kDa adaptor protein, which contains two N-terminal WW-domains and a catalytic domain at its C-terminus homologous to short-chain dehydrogenase/reductase (SDR) family proteins. A high sequence conservation of orthologues from insects to rodents and ultimately humans suggest its significant role in physiology and homeostasis. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2018.00420/
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http://dx.doi.org/10.3389/fonc.2018.00420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194312PMC
October 2018
4 Reads

Hypoxia-inducible factor 1α protects peripheral sensory neurons from diabetic peripheral neuropathy by suppressing accumulation of reactive oxygen species.

J Mol Med (Berl) 2018 Dec 25;96(12):1395-1405. Epub 2018 Oct 25.

Institute of Pharmacology, Heidelberg University, Im Neuenheimer Feld 366, D-69120, Heidelberg, Germany.

Diabetic peripheral neuropathy (DPN) is one of the most common diabetic complications. Mechanisms underlying nerve damage and sensory loss following metabolic dysfunction remain largely unclear. Recently, hyperglycemia-induced mitochondrial dysfunction and the generation of reactive oxygen species (ROS) have gained attention as possible mechanisms of organ damage in diabetes. Read More

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http://link.springer.com/10.1007/s00109-018-1707-9
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http://dx.doi.org/10.1007/s00109-018-1707-9DOI Listing
December 2018
7 Reads

Rhabdomyolysis with Peripheral Neuropathy: A Case Series and Literature Review.

Am J Case Rep 2018 Oct 26;19:1272-1278. Epub 2018 Oct 26.

Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.

BACKGROUND Rhabdomyolysis is a syndrome characterized by muscle necrosis and secretion of intracellular muscle components into the blood circulation. Acute compartment syndrome is a potential complication of severe rhabdomyolysis. CASE REPORT We report 3 cases of compartment syndrome-related peripheral neuropathy in alcoholic individuals with rhabdomyolysis. Read More

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https://www.amjcaserep.com/abstract/index/idArt/911602
Publisher Site
http://dx.doi.org/10.12659/AJCR.911602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214146PMC
October 2018
6 Reads

Prion-related peripheral neuropathy in sporadic Creutzfeldt-Jakob disease.

J Neurol Neurosurg Psychiatry 2018 Oct 24. Epub 2018 Oct 24.

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy

Objective: To assess whether the involvement of the peripheral nervous system (PNS) belongs to the phenotypic spectrum of sporadic Creutzfeldt-Jakob disease (sCJD).

Methods: We examined medical records of 117 sCJDVV2 (ataxic type), 65 sCJDMV2K (kuru-plaque type) and 121 sCJDMM(V)1 (myoclonic type) subjects for clinical symptoms, objective signs and neurophysiological data. We reviewed two diagnostic nerve biopsies and looked for abnormal prion protein (PrP) by western blotting and real-time quaking-induced conversion (RT-QuIC) in postmortem PNS samples from 14 subjects. Read More

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http://dx.doi.org/10.1136/jnnp-2018-319221DOI Listing
October 2018
1 Read

Emerging Roles of Vascular Endothelium in Metabolic Homeostasis.

Circ Res 2018 Aug;123(4):477-494

University of Arkansas for Medical Sciences, Little Rock (C.P.).

Our understanding of the role of the vascular endothelium has evolved over the past 2 decades, with the recognition that it is a dynamically regulated organ and that it plays a nodal role in a variety of physiological and pathological processes. Endothelial cells (ECs) are not only a barrier between the circulation and peripheral tissues, but also actively regulate vascular tone, blood flow, and platelet function. Dysregulation of ECs contributes to pathological conditions such as vascular inflammation, atherosclerosis, hypertension, cardiomyopathy, retinopathy, neuropathy, and cancer. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31323
Publisher Site
http://dx.doi.org/10.1161/CIRCRESAHA.118.313237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205216PMC
August 2018
5 Reads

Evaluation of health utility values for diabetic complications, treatment regimens, glycemic control and other subjective symptoms in diabetic patients using the EQ-5D-5L.

Acta Diabetol 2018 Oct 23. Epub 2018 Oct 23.

Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.

Aims: This study aimed to reveal health utility values for diabetic complications and treatment regimens with adjustment for glycemic control and other clinical manifestations in a diabetic population.

Methods: The EuroQol 5-Dimension 5-Level (EQ-5D-5L) health utility values for 4963 Japanese diabetic patients were analyzed using a multivariate regression model including major complications and treatment regiments (minimally adjusted model), and that additionally included glycemic control and other subjective symptoms (musculoskeletal, dental, respiratory, gastrointestinal, urinary, and cutaneous symptoms, and hearing impairment) (further adjusted model).

Results: The mean utility value was 0. Read More

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http://dx.doi.org/10.1007/s00592-018-1244-6DOI Listing
October 2018
2 Reads

Elsberg syndrome related to varicella zoster virus infection with painless skin lesions in an elderly woman with poorly controlled type 2 diabetes mellitus.

Ther Clin Risk Manag 2018 9;14:1951-1954. Epub 2018 Oct 9.

Division of Diabetes and Metabolic Diseases, Nihon University School of Medicine, Tokyo, Japan,

Patients with diabetes mellitus (DM) are at increased risk of infections, with the urinary tract being the most frequent infection site. Incomplete bladder emptying, frequent urination and abdominal distension are typical symptoms of urinary tract infections (UTIs). A 68-year-old female with a long history of poorly controlled type 2 DM (T2DM) visited our hospital complaining of urinary retention, which was initially diagnosed as cystitis by another doctor. Read More

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http://dx.doi.org/10.2147/TCRM.S178782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186309PMC
October 2018
1 Read

Improving the Reliability and Utility of Streptozotocin-Induced Rat Diabetic Model.

J Diabetes Res 2018 23;2018:8054073. Epub 2018 Sep 23.

Department of Therapeutics, Chromocell Corporation, 685 U.S. Highway One, North Brunswick, NJ 08902, USA.

The Streptozotocin- (STZ-) induced diabetic model is widely used; however, unexplained acute toxicity has given the model an unreliable reputation. To improve the reliability and utility of this model, we characterize the age dependence of STZ toxicity and introduce novel endpoints to assess diabetic complications and reveal possible mechanisms for diabetic development. Diabetes was induced by STZ injection into male, 6 to 23 weeks old, Sprague-Dawley rats. Read More

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https://www.hindawi.com/journals/jdr/2018/8054073/
Publisher Site
http://dx.doi.org/10.1155/2018/8054073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174751PMC
September 2018
7 Reads

Sight-threatening Graves' orbitopathy: Twenty years' experience of a multidisciplinary thyroid-eye outpatient clinic.

Clin Endocrinol (Oxf) 2019 Jan 19;90(1):208-213. Epub 2018 Nov 19.

Department of Endocrinology, Metabolic Diseases and Nutrition, Hôpital Larrey, University Hospital Centre, Toulouse, France.

Context: Sight-threatening Graves' orbitopathy affects 3% to 5% of patients with Graves' orbitopathy.

Objectives: To describe the management of patients with sight-threatening Graves' orbitopathy seen in a multidisciplinary thyroid-eye outpatient clinic dedicated to Graves' orbitopathy (GO).

Patients And Methods: We enrolled all patients with sight-threatening GO (dysthyroid optic neuropathy and corneal ulcer as defined in the EUGOGO statement) seen and treated in our GO multidisciplinary thyroid-eye outpatient clinic over the last two decades. Read More

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http://dx.doi.org/10.1111/cen.13880DOI Listing
January 2019
5 Reads

Cognitive impairment and postural control deficit in adults with Type 2 diabetes.

Diabetes Metab Res Rev 2018 Oct 19:e3089. Epub 2018 Oct 19.

School of Nursing, The University of Texas Health San Antonio, San Antonio, TX, USA.

Background: Diseases induced by metabolic disorders, eg, Type 2 diabetes, has recently been linked to both sensory and motor deficit in the absence of a formal clinical diagnosis of peripheral neuropathy. Studies have demonstrated mild cognitive impairment in diabetic patients, which also plays a role in one's loss of ability to successfully perform basic motor activities. This project focused on evaluating cognitive function while maintaining balance. Read More

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http://doi.wiley.com/10.1002/dmrr.3089
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http://dx.doi.org/10.1002/dmrr.3089DOI Listing
October 2018
8 Reads

Observational clinical and nerve conduction study on effects of a nutraceutical combination on painful diabetic distal symmetric sensory-motor neuropathy in patients with diabetes type 1 and type 2.

Minerva Med 2018 Oct;109(5):358-362

Dementia Center, Neurology Clinic, Tor Vergata Polyclinic, Rome, Italy.

Background: Painful distal symmetric polyneuropathy (pDSPN) is one of the most common and invalidating complications of diabetes mellitus, both of type 1 and type 2. Mechanisms responsible for the occurrence of the pDSPN are multifactorial and involve metabolic pathways regulating inflammation, microvessel circulation, axonal degeneration and so on. Several therapeutic approaches have been proposed to treat pain and each of them showed positive effects associated to drug-related side effects. Read More

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http://dx.doi.org/10.23736/S0026-4806.18.05710-5DOI Listing
October 2018
1 Read

A phase II evaluation of elesclomol sodium and weekly paclitaxel in the treatment of recurrent or persistent platinum-resistant ovarian, fallopian tube or primary peritoneal cancer: An NRG oncology/gynecologic oncology group study.

Gynecol Oncol 2018 Dec 8;151(3):422-427. Epub 2018 Oct 8.

Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center, New York, NY, USA. Electronic address:

Objective: Preclinical data suggest elesclomol increases oxidative stress and enhances sensitivity to cytotoxic agents. The objective of this prospective multicenter phase 2 trial was to estimate the activity of IV elesclomol plus weekly paclitaxel in patients with platinum-resistant recurrent ovarian, tubal or peritoneal cancer through the frequency of objective tumor responses (ORR).

Methods: Patients with measurable disease, acceptable organ function, performance status ≤ 2, and one prior platinum containing regimen were eligible. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183128
Publisher Site
http://dx.doi.org/10.1016/j.ygyno.2018.10.001DOI Listing
December 2018
5 Reads

Neuropathology of vitamin B deficiency in the Cd320 mouse.

FASEB J 2018 Oct 10:fj201800754RR. Epub 2018 Oct 10.

Department of Medicine, and SUNY Downstate Medical Center, Brooklyn, New York, USA.

In humans, vitamin B deficiency causes peripheral and CNS manifestations. Loss of myelin in the peripheral nerves and the spinal cord (SC) contributes to peripheral neuropathy and motor deficits. The metabolic basis for the demyelination and brain disorder is unknown. Read More

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https://www.fasebj.org/doi/10.1096/fj.201800754RR
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http://dx.doi.org/10.1096/fj.201800754RRDOI Listing
October 2018
1 Read

Electrodiagnosis in the Patient with Metabolic Syndrome: Adding Value to Patient Care.

Authors:
Karen P Barr

Phys Med Rehabil Clin N Am 2018 11 17;29(4):735-749. Epub 2018 Sep 17.

Division of Physical Medicine and Rehabilitation, Department of Orthopaedics, West Virginia University, Box 9100, 1 Medical Center Drive, Morgantown, WV 26506, USA. Electronic address:

Patients with metabolic syndrome are at increased risk of peripheral neuropathy; entrapment neuropathies, such as carpal tunnel syndrome; and spine disease that can lead to radiculopathy or spinal stenosis. Electrodiagnostic studies are a valuable part of patient care in this population. They can confirm suspected diagnoses, uncover additional conditions, and lead to the diagnosis of other causes of neuropathy that require treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10479651183079
Publisher Site
http://dx.doi.org/10.1016/j.pmr.2018.06.008DOI Listing
November 2018
3 Reads

Value-Added Electrodiagnostics: Targeting Interventions for Fall Risk Reduction.

Phys Med Rehabil Clin N Am 2018 11 7;29(4):645-657. Epub 2018 Sep 7.

Department of Physical Medicine and Rehabilitation, Michigan Medicine, 325 E Eisenhower Parkway Suite 100, Ann Arbor, MI 48108-3364, USA.

Walking confers numerous health benefits, particularly for middle-aged and older patients with diabetes and metabolic syndrome. Nevertheless, it brings a risk of injurious falls, especially among populations with diabetes and metabolic syndrome-related distal neuromuscular decline and frank neuropathy. Those who stand to benefit most from walking are at greatest risk. Read More

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http://dx.doi.org/10.1016/j.pmr.2018.06.001DOI Listing
November 2018
4 Reads