3,278 results match your criteria Metabolic Neuropathy


Caspase-11-mediated enteric neuronal pyroptosis underlies Western diet-induced colonic dysmotility.

J Clin Invest 2020 Jun 2. Epub 2020 Jun 2.

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Enteric neuronal degeneration, as seen in inflammatory bowel disease, obesity, and diabetes, can lead to gastrointestinal dysmotility. Pyroptosis is a novel form of programmed cell death but little is known about its role in enteric neuronal degeneration. We observed higher levels of cleaved caspase-1, a marker of pyroptosis, in myenteric ganglia of overweight and obese human subjects compared with normal-weight subjects. Read More

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http://dx.doi.org/10.1172/JCI130176DOI Listing

[Severe polyneuropathy in primary Sjögren's syndrome : Sjögren's syndrome should be considered in patients with motor neuropathy].

Z Rheumatol 2020 May 30. Epub 2020 May 30.

Klinik für Rheumatologie und Immunologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

A 64-year-old male patient developed over a period of 20 years a peripheral neuropathy symmetrically affecting the upper and lower limbs. The histological examination of a sural nerve biopsy revealed a severe axonal neuropathy. Despite extensive laboratory investigations including immunological and metabolic tests the origin could not be identified. Read More

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http://dx.doi.org/10.1007/s00393-020-00821-3DOI Listing

Beneficial effects of ferulic acid alone and in combination with insulin in streptozotocin induced diabetic neuropathy in Sprague Dawley rats.

Life Sci 2020 May 27:117856. Epub 2020 May 27.

Pharmacology Division, University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh 160014, India. Electronic address:

Background: Ferulic acid (FA) is a phenolic phytochemical known to protect against various diabetic complications. However, its role in diabetic neuropathy is still unclear. The present study investigated the potential protective effects of FA alone and its combination with insulin against streptozotocin (STZ)-induced diabetic neuropathy in rats. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117856DOI Listing

BAG3 Pro209 mutants associated with myopathy and neuropathy relocate chaperones of the CASA-complex to aggresomes.

Sci Rep 2020 May 29;10(1):8755. Epub 2020 May 29.

Peripheral Neuropathy Research Group, Department of Biomedical Sciences, Institute Born Bunge, University of Antwerp, Antwerp, Belgium.

Three missense mutations targeting the same proline 209 (Pro209) codon in the co-chaperone Bcl2-associated athanogene 3 (BAG3) have been reported to cause distal myopathy, dilated cardiomyopathy or Charcot-Marie-Tooth type 2 neuropathy. Yet, it is unclear whether distinct molecular mechanisms underlie the variable clinical spectrum of the rare patients carrying these three heterozygous Pro209 mutations in BAG3. Here, we studied all three variants and compared them to the BAG3_Glu455Lys mutant, which causes dilated cardiomyopathy. Read More

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http://dx.doi.org/10.1038/s41598-020-65664-zDOI Listing

Systematic clinical approach for diagnosing upper limb tremor.

J Neurol Neurosurg Psychiatry 2020 May 26. Epub 2020 May 26.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

Tremor is the most common movement disorder worldwide, but diagnosis is challenging. In 2018, the task force on tremor of the International Parkinson and Movement Disorder Society published a consensus statement that proposes a tremor classification along two independent axes: a clinical tremor syndrome and its underlying aetiology. In line with this statement, we here propose a stepwise diagnostic approach that leads to the correct clinical and aetiological classification of upper limb tremor. Read More

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http://dx.doi.org/10.1136/jnnp-2019-322676DOI Listing

An unbiased lipidomics approach identifies key lipid molecules as potential therapeutic targets of Dohongsamul-tang against non-alcoholic fatty liver diseases in a mouse model of obesity.

J Ethnopharmacol 2020 May 23:112999. Epub 2020 May 23.

Clinical Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, 34054, Daejeon, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: . Dohongsamul-tang (DST) is a traditional herbal formula used to promote the blood circulation and inhibit inflammation, and also widely has been used in the treatment of patients with chronic liver diseases in Korea and China.

Aim Of The Study: . Read More

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http://dx.doi.org/10.1016/j.jep.2020.112999DOI Listing

Health Care Costs Associated With Macrovascular, Microvascular, and Metabolic Complications of Type 2 Diabetes Across Time: Estimates From a Population-Based Cohort of More Than 0.8 Million Individuals With Up to 15 Years of Follow-up.

Diabetes Care 2020 May 22. Epub 2020 May 22.

Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Objective: Developing country-specific unit-cost catalogs is a key area for advancing economic research to improve medical and policy decisions. However, little is known about how health care costs vary by type 2 diabetes (T2D) complications across time in Asian countries. We sought to quantify the economic burden of various T2D complications in Taiwan. Read More

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http://dx.doi.org/10.2337/dc20-0072DOI Listing

Inverse Correlation Between Grip Strength and Serum Phosphorus: A Retrospective Observational Study in Japanese Elderly with Poorly Controlled Type 2 Diabetes.

Geriatrics (Basel) 2020 May 19;5(2). Epub 2020 May 19.

Department of Internal Medicine, Nihon University Hospital, Tokyo 101-8309, Japan.

The aim of this study was to investigate factors associated with sarcopenia among elderly patients with poorly controlled diabetes mellitus (DM). We retrospectively analyzed 41 patients with type 2 DM, aged ≥65 years who required diabetes education hospitalization. Patients were classified into two groups according to the presence or absence of a weakened hand grip, and clinical characteristics were compared. Read More

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http://dx.doi.org/10.3390/geriatrics5020033DOI Listing

Which Method for Diagnosing Small Fiber Neuropathy?

Front Neurol 2020 5;11:342. Epub 2020 May 5.

Department of Neurology, Toulouse University Hospital, Toulouse, France.

Small fiber neuropathies (SFN) induce pain and/or autonomic symptoms. The diagnosis of SFN poses a challenge because the role of skin biopsy as a reference method and of each neurophysiological test remain to be discussed. This study compares six methods evaluating small sensory and autonomic nerve fibers: skin biopsy, Quantitative Sensory Testing (QST), quantitative sweat measurement system (Q-Sweat), Laser Evoked Potentials (LEP), Electrochemical Skin Conductance (ESC) measurement and Autonomic CardioVascular Tests (ACVT). Read More

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http://dx.doi.org/10.3389/fneur.2020.00342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214721PMC

Advances with Long Non-Coding RNAs in Diabetic Peripheral Neuropathy.

Diabetes Metab Syndr Obes 2020 30;13:1429-1434. Epub 2020 Apr 30.

Department of Endocrinology, Jinshan Hospital, Fudan University, Shanghai, People's Republic of China.

Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs longer than 200 nucleotides, which are defined as transcripts. The lncRNAs are involved in regulating gene expression at epigenetic, transcriptional, and post-transcriptional levels. Recent studies have found that lncRNA is closely related to many diseases like neurological diseases, endocrine and metabolic disorders. Read More

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http://dx.doi.org/10.2147/DMSO.S249232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201007PMC

Evolving concepts on the role of dyslipidemia, bioenergetics, and inflammation in the pathogenesis and treatment of diabetic peripheral neuropathy.

J Peripher Nerv Syst 2020 May 15. Epub 2020 May 15.

Department of Neurology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.

Diabetic peripheral neuropathy (DPN) is one of the most widespread and disabling neurological conditions, accounting for half of all neuropathy cases worldwide. Despite its high prevalence, no approved disease modifying therapies exist. There is now a growing body of evidence that DPN secondary to type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) represents different disease processes, with T2DM DPN best understood within the context of metabolic syndrome rather than hyperglycemia. Read More

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http://dx.doi.org/10.1111/jns.12387DOI Listing

Simplifying the clinical classification of polymerase gamma (POLG) disease based on age of onset; studies using a cohort of 155 cases.

J Inherit Metab Dis 2020 Jan 6. Epub 2020 Jan 6.

Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway.

Background: Variants in POLG are one of the most common causes of inherited mitochondrial disease. Phenotypic classification of POLG disease has evolved haphazardly making it complicated and difficult to implement in everyday clinical practise. The aim of our study was to simplify the classification and facilitate better clinical recognition. Read More

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http://dx.doi.org/10.1002/jimd.12211DOI Listing
January 2020

A Review of Statistical and Machine Learning Techniques for Microvascular Complications in Type 2 Diabetes.

Curr Diabetes Rev 2020 May 10. Epub 2020 May 10.

Department of Computer Science & Engineering, Punjab Engineering College, Sector 12, Chandigarh-160012. India.

Background and Introduction: Diabetes mellitus is a metabolic disorder that has emerged as a serious public health issue worldwide. According to the World Health Organization (WHO), without interventions, the number of diabetic incidences is expected to be at least 629 million by 2045. Uncontrolled diabetes gradually leads to progressive damage to eyes, heart, kidneys, blood vessels and nerves. Read More

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http://dx.doi.org/10.2174/1573399816666200511003357DOI Listing

Temperature- and Pressure-Regulating Insoles for Prevention of Diabetic Foot Ulcers.

J Foot Ankle Surg 2020 May 6. Epub 2020 May 6.

Principal Investigator, Vivonics Inc., Bedford, MA.

Diabetic foot ulcers (DFUs) pose a major threat to the United States healthcare system as well as patients and their families. High ulcer recurrence rates indicate that existing preventive measures are not effective. A new generation of multimodal preventive devices may reduce ulceration and amputation rates. Read More

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http://dx.doi.org/10.1053/j.jfas.2019.05.009DOI Listing
May 2020
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Characterization of experimental diabetic neuropathy using multicontrast magnetic resonance neurography at ultra high field strength.

Sci Rep 2020 May 5;10(1):7593. Epub 2020 May 5.

Department of Medicine I and Clinical Chemistry, Heidelberg University Hospital, INF 410, Heidelberg, Germany.

In light of the limited treatment options of diabetic polyneuropathy (DPN) available, suitable animal models are essential to investigate pathophysiological mechanisms and to identify potential therapeutic targets. In vivo evaluation with current techniques, however, often provides only restricted information about disease evolution. In the study of patients with DPN, magnetic resonance neurography (MRN) has been introduced as an innovative diagnostic tool detecting characteristic lesions within peripheral nerves. Read More

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http://dx.doi.org/10.1038/s41598-020-64585-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200726PMC

Variants in and Not Necessarily Indicate Familial Amyotrophic Lateral Sclerosis or Limb Girdle Muscular Dystrophy 1G in Acute Muscular Respiratory Failure.

J Neurosci Rural Pract 2020 Apr 2;11(2):353-354. Epub 2020 May 2.

Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria.

Genetic work-up is useful for the identification of a primary myopathy. However, even sophisticated genetic methods may fail to detect the underlying cause of myopathy as in the following case. The patient is a 52-year-old female with a history of epilepsy, arterial hypertension, atrial flutter requiring cardioversion, ablation, and anticoagulation, coronary heart disease, hyperlipidemia, and hyper-CKemia. Read More

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http://dx.doi.org/10.1055/s-0040-1709375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195953PMC

The Relevance of Oxidative Stress in the Pathogenesis and Therapy of Retinal Dystrophies.

Antioxidants (Basel) 2020 Apr 23;9(4). Epub 2020 Apr 23.

Departament de Genètica, Microbiologia i Estadística, Avda. Diagonal 643, Universitat de Barcelona, 08028 Barcelona, Spain.

Retinal cell survival requires an equilibrium between oxygen, reactive oxygen species, and antioxidant molecules that counteract oxidative stress damage. Oxidative stress alters cell homeostasis and elicits a protective cell response, which is most relevant in photoreceptors and retinal ganglion cells, neurons with a high metabolic rate that are continuously subject to light/oxidative stress insults. We analyze how the alteration of cellular endogenous pathways for protection against oxidative stress leads to retinal dysfunction in prevalent (age-related macular degeneration, glaucoma) as well as in rare genetic visual disorders (Retinitis pigmentosa, Leber hereditary optic neuropathy). Read More

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http://dx.doi.org/10.3390/antiox9040347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222416PMC

Evaluating the effectiveness of a support programme for people with type 2 diabetes mellitus in primary care: an observational prospective study in Ecuador.

BJGP Open 2020 Apr 21. Epub 2020 Apr 21.

College of Medicine, Pontifical Catholic University of Ecuador, Quito, Ecuador.

Background: The success of primary health care relies on the integration of empowered practitioners with cooperative patients regardless of socioeconomic status. Using resources efficiently would help to improve healthcare promotion and reduce complications of chronic non-communicable diseases (NCDs). The importance of network support programmes relies on the fact that they allow to accurately deliver medical care by shaping a sense of community and purpose among the patients. Read More

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http://dx.doi.org/10.3399/bjgpopen20X101025DOI Listing

Metabolic Factors, Lifestyle Habits, and Possible Polyneuropathy in Early Type 2 Diabetes: A Nationwide Study of 5,249 Patients in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Cohort.

Diabetes Care 2020 Jun 15;43(6):1266-1275. Epub 2020 Apr 15.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Objective: To investigate the association of metabolic and lifestyle factors with possible diabetic polyneuropathy (DPN) and neuropathic pain in patients with early type 2 diabetes.

Research Design And Methods: We thoroughly characterized 6,726 patients with recently diagnosed diabetes. After a median of 2. Read More

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http://dx.doi.org/10.2337/dc19-2277DOI Listing

Gitelman syndrome associated with chondrocalcinosis and severe neuropathy: a novel heterozygous mutation in SLC12A3 gene.

Reumatismo 2020 Apr 10;72(1):67-70. Epub 2020 Apr 10.

Unit of Rheumatology, Università di Modena e Reggio Emilia, Modena.

Gitelman syndrome (GS) is an inherited salt-wasting tubulopathy characterized by hypocalciuria, hypokalemia, hypomagnesemia and metabolic alkalosis, due to inactivating mutations in the SLC12A3 gene. Symptoms may be systemic, neurological, cardiovascular, ophthalmological or musculoskeletal. We describe a 70 year-old patient affected by recurrent arthralgias, hypoesthesia and hyposthenia in all 4 limbs and severe hypokalemia, complicated by atrial flutter. Read More

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http://dx.doi.org/10.4081/reumatismo.2020.1255DOI Listing

Early prevention of diabetes microvascular complications in people with hyperglycaemia in Europe. ePREDICE randomized trial. Study protocol, recruitment and selected baseline data.

PLoS One 2020 13;15(4):e0231196. Epub 2020 Apr 13.

Departamento de Salud Internacional, Escuela Nacional de Sanidad, Instituto de Salud Carlos III, Madrid, Spain.

Objectives: To assess the effects of early management of hyperglycaemia with antidiabetic drugs plus lifestyle intervention compared with lifestyle alone, on microvascular function in adults with pre-diabetes.

Methods: Trial design: International, multicenter, randomised, partially double-blind, placebo-controlled, clinical trial.

Participants: Males and females aged 45-74 years with IFG, IGT or IFG+IGT, recruited from primary care centres in Australia, Austria, Bulgaria, Greece, Kuwait, Poland, Serbia, Spain and Turkey. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231196PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153858PMC

Associations of food addiction with metabolic control, medical complications and depression among patients with type 2 diabetes.

Acta Diabetol 2020 Apr 10. Epub 2020 Apr 10.

Endocrinology and Nutrition Department, Hospital Son Llàtzer, University Institute of Health Science Research (IUNICS) and Health Research Institute of Balearic Islands (IdISBA), Ctra Manacor km 4, 07198, Palma de Mallorca, Baleares, Spain.

Aims: Food addiction (FA) is conceptualized as a behavioral pattern that is similar in some ways to addictions to alcohol and other substances. This disorder has not been well studied among patients with type 2 diabetes (T2DM). We aimed to analyze if there is any relationship between FA and clinical or psychological variables among patients with T2DM. Read More

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http://dx.doi.org/10.1007/s00592-020-01519-3DOI Listing

TRPV1 Tunes Optic Nerve Axon Excitability in Glaucoma.

Front Physiol 2020 26;11:249. Epub 2020 Mar 26.

Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN, United States.

The transient receptor potential vanilloid member 1 (TRPV1) in the central nervous system may contribute to homeostatic plasticity by regulating intracellular Ca, which becomes unbalanced in age-related neurodegenerative diseases, including Alzheimer's and Huntington's. Glaucomatous optic neuropathy - the world's leading cause of irreversible blindness - involves progressive degeneration of retinal ganglion cell (RGC) axons in the optic nerve through sensitivity to stress related to intraocular pressure (IOP). In models of glaucoma, genetic deletion of TRPV1 ( ) accelerates RGC axonopathy in the optic projection, whereas TRPV1 activation modulates RGC membrane polarization. Read More

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http://dx.doi.org/10.3389/fphys.2020.00249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113399PMC

Combining brentuximab vedotin with dexamethasone, high-dose cytarabine and cisplatin as salvage treatment in relapsed or refractory Hodgkin lymphoma: the phase II HOVON/LLPC Transplant BRaVE study.

Haematologica 2020 Apr 9. Epub 2020 Apr 9.

Dept of Hematology, Amsterdam UMC, University of Amsterdam, and LYMMCARE, Amsterdam, The Netherlands.

Achieving a metabolic complete response (mCR) before high-dose chemotherapy (HDC) and autologous peripheral blood stem-cell transplant (auto-PBSCT) predicts progression free survival (PFS) in relapsed/refractory classical Hodgkin lymphoma (R/R cHL). We added brentuximab vedotin (BV) to DHAP to improve the mCR rate. In a Phase I dose-escalation part in 12 patients, we showed that BV-DHAP is feasible. Read More

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http://dx.doi.org/10.3324/haematol.2019.243238DOI Listing

Glycaemic Control and Vascular Complications in Diabetes Mellitus Type 2.

Adv Exp Med Biol 2020 Apr 8. Epub 2020 Apr 8.

Vita-Salute San Raffaele University and San Raffaele Scientific Institute, Milan, Italy.

Diabetes mellitus is constantly increasing worldwide. Vascular complications are the most common in the setting of long-standing disease, claiming the greatest burden in terms of morbidity and mortality. Glucotoxicity is involved in vascular damage through different metabolic pathways, such as production of advanced glycation end-products, activation of protein kinase C, polyol pathway activation and production of reactive oxygen species. Read More

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http://dx.doi.org/10.1007/5584_2020_514DOI Listing

Expression profiles of long noncoding RNAs in retinopathy of prematurity.

Neural Regen Res 2020 Oct;15(10):1962-1968

Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China.

Long noncoding RNA (lncRNA) regulates the proliferation and migration of human retinal endothelial cells, as well as retinal neovascularization in diabetic retinopathy. Based on similarities between the pathogenesis of retinopathy of prematurity (ROP) and diabetic retinopathy, lncRNA may also play a role in ROP. Seven-day-old mice were administered 75 ± 2% oxygen for 5 days and normoxic air for another 5 days to establish a ROP model. Read More

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http://dx.doi.org/10.4103/1673-5374.280328DOI Listing
October 2020

Higher proteotoxic stress rather than mitochondrial damage is involved in higher neurotoxicity of bortezomib compared to carfilzomib.

Redox Biol 2020 May 21;32:101502. Epub 2020 Mar 21.

Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey. Electronic address:

Proteasome inhibitors have great success for their therapeutic potential against hematologic malignancies. First generation proteasome inhibitor bortezomib induced peripheral neuropathy is considered as a limiting factor in chemotherapy and its second-generation counterpart carfilzomib is associated with lower rates of neurotoxicity. The mitochondrial toxicity (mitotoxicity) hypothesis arises from studies with animal models of bortezomib induced peripheral neuropathy. Read More

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http://dx.doi.org/10.1016/j.redox.2020.101502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115161PMC

[New thoughts on material basis and mechanism of Yin-tonifying traditional Chinese medicine in treatment of diabetes mellitus and its complications].

Zhongguo Zhong Yao Za Zhi 2020 Feb;45(3):531-538

School of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 211198, China.

Diabetes mellitus is a serious chronic metabolic disease, and the patient's hyperglycemia is often accompanied by complications. In the circles of medical science, traditional Chinese medicine(TCM) has the earliest knowledge and research about diabetes. According to TCM, the clinical characteristics of diabetes mellitus were basically the same as "Xiaoke". Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20190826.502DOI Listing
February 2020

Dose Adjustment of Oxaliplatin Based on Renal Function in Patients With Metastatic Colorectal Cancer.

Anticancer Res 2020 Apr;40(4):2379-2386

Department of Pharmacy, Gifu University Hospital, Gifu, Japan.

Background/aim: The effect of renal dysfunction on the toxicity and efficacy of oxaliplatin remains unclear. We investigated the association between creatinine clearance (Ccr), a marker of renal function, and the toxicity and efficacy of oxaliplatin in patients with metastatic colorectal cancer (mCRC).

Patients And Methods: Patients with mCRC who received oxaliplatin-based chemotherapy as first-line treatment were included in this study. Read More

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http://dx.doi.org/10.21873/anticanres.14207DOI Listing

Specific gene expression in type 1 diabetic patients with and without cardiac autonomic neuropathy.

Sci Rep 2020 Mar 27;10(1):5554. Epub 2020 Mar 27.

Department of Metabolic Diseases, University Hospital, Krakow, Poland.

We hypothesized that some molecular pathways might interact to initiate the process of nervous tissue destruction, promoting cardiac autonomic neuropathy (CAN) in the course of diabetes type 1 (T1D). The study group consisted of 60 T1D patients (58.33% women/41. Read More

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http://dx.doi.org/10.1038/s41598-020-62498-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101413PMC

The Role of Autophagy in Glaucomatous Optic Neuropathy.

Front Cell Dev Biol 2020 4;8:121. Epub 2020 Mar 4.

Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, Rende, Italy.

Autophagy is a conserved lysosomal-dependent pathway responsible for the degradation of cytoplasmic macromolecules. Based on the mechanism of cargo delivery to lysosomes, mammalian cells can undergo micro, macro, and chaperone-mediated autophagy. Other than physiological turnover of proteins and organelles, autophagy regulates cellular adaptation to different metabolic states and stressful conditions by allowing cellular survival or, when overactivated, participating to cell death. Read More

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http://dx.doi.org/10.3389/fcell.2020.00121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066980PMC

Hyperpigmentation and thickening of skin with callosity formation over dorsum of both feet and healed ulceration over left lateral malleolus in a patient with type 2 diabetes performing prolonged prayers.

Diabetes Metab Syndr 2020 May - Jun;14(3):221-223. Epub 2020 Jan 3.

Fortis C-DOC Centre of Excellence for Diabetes, Metabolic Diseases and Endocrinology, India. Electronic address:

Many types of skin lesions have been described in patients with diabetes, but prolonged prayer-induced hyperkeratosis and callous formation are rare. We describe such lesions in a 62-year-old Muslim patient with uncontrolled glycemia who practiced prolonged, repeated religious prayers in sitting position causing significant pressure over dorsum of both ankles. He developed prayer-induced callous formation on dorsum of both ankles, with more thickening and a healed ulcer on left. Read More

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http://dx.doi.org/10.1016/j.dsx.2019.12.008DOI Listing
January 2020

A Metabolic Insight Into the Neuroprotective Effect of Jin-Mai-Tong (JMT) Decoction on Diabetic Rats With Peripheral Neuropathy Using Untargeted Metabolomics Strategy.

Front Pharmacol 2020 5;11:221. Epub 2020 Mar 5.

Medical Research Center, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Jin-Mai-Tong (JMT) decoction is a traditional Chinese compound prescription for treating diabetic peripheral neuropathy (DPN). The aim of this study is to investigate the neuroprotective effect of JMT decoction on diabetic rats with peripheral neuropathy and to elucidate the potential mechanism based on a metabolomics approach. Sprague-Dawley (SD) rats were randomly divided into four groups: control group, Streptozotocin (STZ) induced model group, JMT low dose (JMT-L) treated group and JMT high dose (JMT-H) treated group. Read More

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http://dx.doi.org/10.3389/fphar.2020.00221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066215PMC

Partial Inhibition of Glycolysis Reduces Atherogenesis Independent of Intraplaque Neovascularization in Mice.

Arterioscler Thromb Vasc Biol 2020 May 19;40(5):1168-1181. Epub 2020 Mar 19.

From the Laboratory of Physiopharmacology (P.P., B.V.d.V., P.-J.G., G.R.Y.D.M., W.M.), University of Antwerp, Belgium.

Objective: Intraplaque neovascularization is an important feature of unstable human atherosclerotic plaques. However, its impact on plaque formation and stability is poorly studied. Because proliferating endothelial cells generate up to 85% of their ATP from glycolysis, we investigated whether pharmacological inhibition of glycolytic flux by the small-molecule 3PO (3-[3-pyridinyl]-1-[4-pyridinyl]-2-propen-1-one) could have beneficial effects on plaque formation and composition. Read More

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http://dx.doi.org/10.1161/ATVBAHA.119.313692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176341PMC

European Headache Federation recommendations for neurologists managing giant cell arteritis.

J Headache Pain 2020 Mar 17;21(1):28. Epub 2020 Mar 17.

Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Background And Aim: Giant cell arteritis (GCA) remains a medical emergency because of the risk of sudden irreversible sight loss and rarely stroke along with other complications. Because headache is one of the cardinal symptoms of cranial GCA, neurologists need to be up to date with the advances in investigation and management of this condition. The aim of this document by the European Headache Federation (EHF) is to provide an evidence-based and expert-based recommendations on GCA. Read More

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http://dx.doi.org/10.1186/s10194-020-01093-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079499PMC

Guidelines on the classification of diabetic foot ulcers (IWGDF 2019).

Diabetes Metab Res Rev 2020 03;36 Suppl 1:e3273

Department of Diabetes and Endocrinology, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, United Kingdom.

The International Working Group on the Diabetic Foot (IWGDF) has been publishing evidence-based guidelines on the prevention and management of diabetic foot disease since 1999. This publication represents a new guideline addressing the use of classifications of diabetic foot ulcers in routine clinical practice and reviews those which have been published. We only consider systems of classification used for active diabetic foot ulcers and do not include those that might be used to define risk of future ulceration. Read More

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http://dx.doi.org/10.1002/dmrr.3273DOI Listing

CMT2Q-causing mutation in the Dhtkd1 gene lead to sensory defects, mitochondrial accumulation and altered metabolism in a knock-in mouse model.

Acta Neuropathol Commun 2020 03 13;8(1):32. Epub 2020 Mar 13.

Department of Medical Genetics, E-Institutes of Shanghai Universities, Shanghai Jiao Tong University School of Medicine (SJTUSM), 280 South Chongqing Road, Shanghai, 200025, People's Republic of China.

Charcot-Marie-Tooth disease (CMT) is a group of inherited neurological disorders of the peripheral nervous system. CMT is subdivided into two main types: a demyelinating form, known as CMT1, and an axonal form, known as CMT2. Nearly 30 genes have been identified as a cause of CMT2. Read More

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http://dx.doi.org/10.1186/s40478-020-00901-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071680PMC

What Every Neuropathologist Needs to Know: Peripheral Nerve Biopsy.

J Neuropathol Exp Neurol 2020 Apr;79(4):355-364

Department of Pathology, University of Chicago, Chicago, Illinois.

Peripheral neuropathy is a common disorder with many possible etiologies including metabolic diseases, inflammatory conditions, infections, malignancy, inherited diseases, drugs, and toxins. In most instances, diagnosis and treatment plan can be established based on clinical presentation, family history, laboratory results, genetic testing, and electrophysiological studies. But in some situations, a peripheral nerve biopsy remains a valuable tool. Read More

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http://dx.doi.org/10.1093/jnen/nlaa012DOI Listing

The prevalence and risk factors of stroke among Sudanese individuals with diabetes: Cross-sectional survey.

Brain Circ 2020 Jan-Mar;6(1):26-30. Epub 2020 Feb 18.

Department of Medicine and HIV Metabolic Clinic, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire, UK.

Introduction: Diabetes complications in Sudan were increasing at an alarming rate. The aim of this study was to assess the prevalence of stroke among Sudanese individuals with diabetes.

Methodology: This cross-sectional study recruited 283 individuals with diabetes from three diabetes centers in Sudan. Read More

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http://dx.doi.org/10.4103/bc.bc_15_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045532PMC
February 2020

A pyruvate dehydrogenase kinase inhibitor prevents retinal cell death and improves energy metabolism in rat retinas after ischemia/reperfusion injury.

Exp Eye Res 2020 Apr 9;193:107997. Epub 2020 Mar 9.

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan; Collaborative Program for Ophthalmic Drug Discovery, Tohoku University Graduate School of Medicine, Miyagi, Japan; Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Miyagi, Japan; Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Miyagi, Japan; Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Miyagi, Japan. Electronic address:

We aimed to assess the neuroprotective effect of a pyruvate dehydrogenase kinase (PDK) inhibitor, Nov3r after ischemia/reperfusion (IR) injury in rats. IR injury was induced by applying 150 mmHg of intraocular pressure for 50 min. Nov3r was orally administered (100 mg/kg) 3 h before and 24 h after IR injury. Read More

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http://dx.doi.org/10.1016/j.exer.2020.107997DOI Listing

Thiamine (vitamin B1) in septic shock: a targeted therapy.

J Thorac Dis 2020 Feb;12(Suppl 1):S78-S83

Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Thiamine (vitamin B1) is a water-soluble vitamin essential for human health. Thiamine deficiency is causal and/or contributory in a number of debilitating diseases including beri-beri, the Wernicke-Korsakoff syndrome, optic neuropathy, and others. While thiamine deficiency is relatively rare in developed nations as a result of dietary supplementation, thiamine deficiency is more common in nutritionally compromised populations. Read More

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http://dx.doi.org/10.21037/jtd.2019.12.82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024754PMC
February 2020

Levels of ankle-brachial index and the risk of diabetes mellitus complications.

BMJ Open Diabetes Res Care 2020 03;8(1)

ISV Girona, IDIAP Jordi Gol, Girona, Catalunya, Spain

Objective: We sought to compare the association of categorized ankle-brachial index (ABI) with mortality and complications of diabetes in persons with no symptoms of peripheral arterial disease (PAD) and in primary cardiovascular disease prevention.

Research Design And Methods: This is a retrospective cohort study of persons with type 2 diabetes aged 35-85 years, from 2006 to 2011. Data were obtained from the Sistema d'Informació per al Desenvolupament de la Investigació en Atenció Primària (SIDIAP). Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-000977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059529PMC

Inherited Metabolic Diseases and Cardiac Pathology in Adults: Diagnosis and Prevalence in a CardioMetabo Study.

J Clin Med 2020 Mar 4;9(3). Epub 2020 Mar 4.

Biochemistry and Molecular Genetic Department, CHU Clermont-Ferrand, Faculty of Medicine, Université Clermont-Auvergne, CNRS 6293, INSERM 1103, GReD, 63000 Clermont-Ferrand, France.

Many inherited metabolic diseases (IMD) have cardiac manifestations. The aim of this study was to estimate the prevalence of IMD in adult patients with hypertrophic cardiomyopathy (HCM) and cardiac rhythm abnormalities that require cardiac implantable electronic devices (CIEDs). The study included a review of the medical files of patients aged 18 to 65 years who were followed in our cardiology department during the period 2010-2017. Read More

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http://dx.doi.org/10.3390/jcm9030694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141305PMC

Prevalence and risk factors of diabetic retinopathy in diabetic patients: A community based cross-sectional study.

Medicine (Baltimore) 2020 Feb;99(9):e19236

Department of Ophthalmology.

In China, there is a significant lack of awareness of diabetes and its complications. Screening of diabetic retinopathy has important for early detection, prevention, and treatment. This large, cross-sectional study aimed to characterize the demographic, physical, serological, and ocular characteristics of subjects with diabetes mellitus in Shijiazhuang, China. Read More

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http://dx.doi.org/10.1097/MD.0000000000019236DOI Listing
February 2020
5.723 Impact Factor

Understanding Metabolic Memory: A Tale of Two Studies.

Diabetes 2020 Mar;69(3):291-299

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.

The results of the Diabetes Control and Complications Trial (DCCT) have given rise to much encouragement in the battle to stave off the complications of type 1 diabetes, showing dramatic declines in the development of severe retinopathy, nephropathy, and neuropathy in those treated intensively compared with conventional therapy. Particularly encouraging has been the continuing difference between the two groups despite both having similar HbA (∼8%) since the end of DCCT, when 96% of participants entered the observational Epidemiology of Diabetes Interventions and Complications (EDIC) study. This continuing relative benefit has been termed "metabolic memory," which implies altered metabolic regulation. Read More

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http://dx.doi.org/10.2337/db19-0514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034186PMC

Endothelin-1 predicts incident diabetic peripheral neuropathy in Type 2 Diabetes: a cohort study.

Eur J Endocrinol 2020 Apr;182(4):429-438

Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Singapore.

Introduction: Diabetic peripheral neuropathy (DPN) is a common microvascular complication in patients with type 2 diabetes (T2D). Apart from hyperglycemia, few modifiable risk factors have been identified. Endothelin-1 is a potent vasoconstrictor peptide, implicated in the causal pathway of microangiopathy. Read More

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http://dx.doi.org/10.1530/EJE-19-0523DOI Listing

A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications.

Biomed Pharmacother 2020 May 12;125:109767. Epub 2020 Feb 12.

Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China. Electronic address:

Diabetes mellitus (DM) is a major world health problem and one of the most studied diseases, which are highly prevalent in the whole world, it is frequently associated with severe clinical complications, such as diabetic cardiomyopathy, nephropathy, retinopathy, neuropathy etc. Scientific research is continuously casting about for new monomer molecules from Chinese herbal medicine that could be invoked as candidate drugs for fighting against diabetes and its complications. Resveratrol (RES), a polyphenol phytoalexin, possesses diverse biochemical and physiological actions, including antiplatelet, estrogenic, and anti-inflammatory properties. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.109767DOI Listing

Serum B12, Homocysteine Levels, and their Effect on Peripheral Neuropathy in Parkinson's Disease: Indian Cohort.

Ann Indian Acad Neurol 2020 Jan-Feb;23(1):48-53

Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Background: Cobalamin deficiency, either due to dietary inadequacy or increased consumption attributable to levodopa-mediated metabolic disturbance, and resultant hyperhomocysteinemia may contribute to peripheral neuropathy (PN) in Parkinson's disease (PD).

Aim: The aim of the study is to assess the prevalence of Vitamin B12 deficiency, hyperhomocysteinemia in Indian PD patients, and their association with PN.

Materials And Methods: Clinical details were collected in 93 patients over a period of 2 years. Read More

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http://dx.doi.org/10.4103/aian.AIAN_478_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001434PMC
February 2020
0.514 Impact Factor

Exercise and insulin-like growth factor 1 supplementation improve angiogenesis and angiogenic cytokines in a rat model of diabetes-induced neuropathy.

Exp Physiol 2020 May 21;105(5):783-792. Epub 2020 Apr 21.

Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

New Findings: What is the central question of this study? Do changes in levels of angiogenesis-related mediators [vascular endothelial growth factor-A (VEGF-A), thrombospondin-1 (TSP-1) and nuclear factor-κB (NF-κB)] in the sciatic nerve mediate diabetic neuropathy in the streptozotocin-induced type 1 diabetic male rat? Can exercise and insulin-like growth factor 1 (IGF-I) treatment improve the diabetes-related decrease in angiogenesis in sciatic nerve in these animals? What is the main finding and its importance? Levels of VEGF-A, TSP-1 and NF-κB change in the sciatic nerve of diabetic rats and might mediate diabetic neuropathy. Treatment with IGF-I and exercise could increase angiogenesis in the diabetic rats by increasing VEGF-A and decreasing TSP-1 and NF-κB expression in the sciatic nerve.

Abstract: Diabetic neuropathy is a severe complication of diabetes that affects 40-50% of diabetic people in the world. Read More

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http://dx.doi.org/10.1113/EP088069DOI Listing
May 2020
2.669 Impact Factor