2,997 results match your criteria Metabolic Neuropathy


Randomised controlled trial of the impact of haemodiafiltration on uraemic neuropathy: FINESSE study protocol.

BMJ Open 2019 Jan 15;9(1):e023736. Epub 2019 Jan 15.

Renal and Metabolic, The George Institute for Global Health, UNSW, Newtown, New South Wales, Australia.

Introduction: The majority of patients undergoing haemodialysis (HD) show evidence of uraemic neuropathy, a condition with no known disease-modifying treatments. The pathogenesis of uraemic neuropathy is poorly understood, but may be related to cumulative exposure to middle molecules or other solutes such as potassium. It is not known whether haemodiafiltration (HDF) reduces the progression of uraemic neuropathy. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023736DOI Listing
January 2019

Intestinal nerve cell injury occurs prior to insulin resistance in female mice ingesting a high-fat diet.

Cell Tissue Res 2019 Feb 18. Epub 2019 Feb 18.

Department of Biological Sciences, University of Idaho, 875 Perimeter Drive, LSS 252, Moscow, ID, 83844, USA.

Diabetic patients suffer from gastrointestinal disorders associated with dysmotility, enteric neuropathy and dysbiosis of gut microbiota; however, gender differences are not fully known. Previous studies have shown that a high-fat diet (HFD) causes type two diabetes (T2D) in male mice after 4-8 weeks but only does so in female mice after 16 weeks. This study seeks to determine whether sex influences the development of intestinal dysmotility, enteric neuropathy and dysbiosis in mice fed HFD. Read More

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http://dx.doi.org/10.1007/s00441-019-03002-0DOI Listing
February 2019

Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease.

Front Cell Neurosci 2019 29;13. Epub 2019 Jan 29.

Departamento de Neurología, Escuela de Medicina and Centro Interdisciplinario de Neurociencias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Oligodendrocytes are the myelin forming cells in the central nervous system (CNS). In addition to this main physiological function, these cells play key roles by providing energy substrates to neurons as well as information required to sustain proper synaptic transmission and plasticity at the CNS. The latter requires a fine coordinated intercellular communication with neurons and other glial cell types, including astrocytes. Read More

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http://dx.doi.org/10.3389/fncel.2019.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361860PMC
January 2019

The Importance of Peripheral Nerves in Adipose Tissue for the Regulation of Energy Balance.

Biology (Basel) 2019 Feb 12;8(1). Epub 2019 Feb 12.

Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME 04469, USA.

Brown and white adipose tissues are essential for maintenance of proper energy balance and metabolic health. In order to function efficiently, these tissues require both endocrine and neural communication with the brain. Brown adipose tissue (BAT), as well as the inducible brown adipocytes that appear in white adipose tissue (WAT) after simulation, are thermogenic and energy expending. Read More

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http://dx.doi.org/10.3390/biology8010010DOI Listing
February 2019

Small heat shock proteins: multifaceted proteins with important implications for life.

Cell Stress Chaperones 2019 Feb 13. Epub 2019 Feb 13.

Laboratory of Cell and Developmental Genetics, IBIS, and Department of Molecular Biology, Medical Biochemistry and Pathology, Medical School, Université Laval, QC, Québec, G1V 0A6, Canada.

Small Heat Shock Proteins (sHSPs) evolved early in the history of life; they are present in archaea, bacteria, and eukaryota. sHSPs belong to the superfamily of molecular chaperones: they are components of the cellular protein quality control machinery and are thought to act as the first line of defense against conditions that endanger the cellular proteome. In plants, sHSPs protect cells against abiotic stresses, providing innovative targets for sustainable agricultural production. Read More

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http://dx.doi.org/10.1007/s12192-019-00979-zDOI Listing
February 2019
2 Reads

Neurologic Conditions: Common Peripheral Neuropathies.

FP Essent 2019 Feb;477:11-15

University of South Alabama College of Medicine Department of Family Medicine, 1601 Center Street, 2N Mobile, AL 36604.

Peripheral neuropathies (PNs) are a group of conditions caused by damage to the peripheral nervous system. PN is a condition commonly seen in the family medicine setting and can lead to reduced quality of life due to pain, ulceration, and falls. More than 100 etiologies of PN have been identified; the most common are metabolic, drug-related, and systemic etiologies. Read More

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February 2019
1 Read

The Effect of Sodium Channel Blocker, Mexiletine, on Body Weight in Type 2 Diabetes Patients with Visceral Obesity.

Authors:
Naohiko Ueno

Clin Med Insights Endocrinol Diabetes 2019 22;12:1179551418825049. Epub 2019 Jan 22.

Ueno Internal Medicine and Diabetes Clinic, Kobe, Japan.

Objective: Mexiletine is an anti-arrhythmic agent also used for the treatment of painful diabetic neuropathy. In this study, the effect of mexiletine on body weight was evaluated in type 2 diabetes patients with diabetic neuropathy exhibiting visceral obesity.

Methods: Type 2 diabetes patients with neuropathy exhibiting visceral obesity (n = 21) treated by mexiletine (300 mg/day) and a control group of type 2 diabetes patients with the same condition who received vitamin B (n = 12) were retrospectively evaluated. Read More

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http://dx.doi.org/10.1177/1179551418825049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343451PMC
January 2019
1 Read

Integrative metabolomics reveals unique metabolic traits in Guillain-Barré Syndrome and its variants.

Sci Rep 2019 Jan 31;9(1):1077. Epub 2019 Jan 31.

The Department of Bio and Fermentation Convergence Technology, BK21 PLUS Program, Kookmin University, Seoul, 02707, Republic of Korea.

Guillain-Barré syndrome (GBS) is an acute fatal progressive disease caused by autoimmune mechanism mainly affecting peripheral nervous system. Although the syndrome is clinically sub-classified into several variants, specific biomarker and exact pathomechanism of each subtypes are not well elucidated yet. In current study, integrative metabolomic and lipidomic profiles were acquisitioned from cerebrospinal fluid samples of 86 GBS from three variants and 20 disease controls. Read More

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http://dx.doi.org/10.1038/s41598-018-37572-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355784PMC
January 2019
1 Read

Mitochondrial uncoupling has no effect on microvascular complications in type 2 diabetes.

Sci Rep 2019 Jan 29;9(1):881. Epub 2019 Jan 29.

Department of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA.

Diabetic peripheral neuropathy (DPN), diabetic kidney disease (DKD), and diabetic retinopathy (DR) contribute to significant morbidity and mortality in diabetes patients. The incidence of these complications is increasing with the diabetes epidemic, and current therapies minimally impact their pathogenesis in type 2 diabetes (T2D). Improved mechanistic understanding of each of the diabetic complications is needed in order to develop disease-modifying treatments for patients. Read More

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http://www.nature.com/articles/s41598-018-37376-y
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http://dx.doi.org/10.1038/s41598-018-37376-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351661PMC
January 2019
2 Reads

Late-onset and fast progressive neuropathy and cardiomyopathy in Val32Ala transthyretin gene mutation.

Neurol Sci 2019 Jan 26. Epub 2019 Jan 26.

Neuroalgology Unit, Department of Clinical Neurosciences, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Via Celoria, 11, 20133, Milan, Italy.

More than 100 mutations of the transthyretin gene have been reported in autosomal dominant familial amyloid polyneuropathy. This rare disease causes severe motor and sensory disability, dysautonomia, and in some patients also cardiomyopathy. The diagnosis can be challenging mainly in sporadic adult patients showing clinical, laboratory, and neurophysiological findings overlapping other forms of chronic neuropathy. Read More

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http://dx.doi.org/10.1007/s10072-019-3716-zDOI Listing
January 2019

HADHA and HADHB gene associated phenotypes - Identification of rare variants in a patient cohort by Next Generation Sequencing.

Mol Cell Probes 2019 Jan 22. Epub 2019 Jan 22.

Medical Genetics Center, Munich, Germany; Department of Neurology, Friedrich-Baur-Institute, Klinikum der Ludwig-Maximilians-University, Munich, Germany. Electronic address:

The heterooctameric mitochondrial trifunctional protein (MTP), composed of four α- and β-subunits harbours three enzymes that each perform a different function in mitochondrial fatty acid β-oxidation. Pathogenic variants in the MTP genes (HADHA and HADHB) cause MTP deficiency, a rare autosomal recessive metabolic disorder characterized by phenotypic heterogeneity ranging from severe, early-onset, cardiac disease to milder, later-onset, myopathy and neuropathy. Since metabolic myopathies and neuropathies are a group of rare genetic disorders and their associated muscle symptoms may be subtle, the diagnosis is often delayed. Read More

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http://dx.doi.org/10.1016/j.mcp.2019.01.003DOI Listing
January 2019
1 Read

Tannins and vascular complications of Diabetes: An update.

Phytomedicine 2018 Oct 22;56:229-245. Epub 2018 Oct 22.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400 056, India. Electronic address:

Background: Diabetes mellitus is a chronic metabolic disorder associated with persistent increased level of glucose in the blood. According to a report by World Health Organisation (WHO), prevalence of diabetes among adults over 18 years of age had reached to 8.5% in year 2014 which was 4. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.10.026DOI Listing
October 2018
4 Reads

Methylglyoxal, a potent inducer of AGEs, connects between diabetes and cancer.

Diabetes Res Clin Pract 2019 Feb 18;148:200-211. Epub 2019 Jan 18.

Metastasis Research Laboratory, GIGA-Cancer, University of Liège, Belgium. Electronic address:

Diabetes is one of the most frequent diseases throughout the world and its incidence is predicted to exponentially progress in the future. This metabolic disorder is associated with major complications such as neuropathy, retinopathy, atherosclerosis, and diabetic nephropathy, the severity of which correlates with hyperglycemia, suggesting that they are triggered by high glucose condition. Reducing sugars and reactive carbonyl species such as methylglyoxal (MGO) lead to glycation of proteins, lipids and DNA and the gradual accumulation of advanced glycation end products (AGEs) in cells and tissues. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.002DOI Listing
February 2019
9 Reads
2.538 Impact Factor

The diabetes pandemic and associated infections: suggestions for clinical microbiology.

Rev Med Microbiol 2019 Jan 1;30(1):1-17. Epub 2018 Nov 1.

Institute of Clinical Physiology, CNR, Pisa, Italy.

There are 425 million people with diabetes mellitus in the world. By 2045, this figure will grow to over 600 million. Diabetes mellitus is classified among noncommunicable diseases. Read More

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http://dx.doi.org/10.1097/MRM.0000000000000155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319590PMC
January 2019
7 Reads

The 2017 Banting Memorial Lecture The diabetic lower limb - a forty year journey: from clinical observation to clinical science.

Diabet Med 2019 Jan 19. Epub 2019 Jan 19.

Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, University of Manchester, Manchester, UK.

A series of clinical research projects conducted over the past 40 years, all of which were informed by clinical observation or discussions with people with diabetes and staff colleagues are described in this review. A study of necrobiosis lipoidica diabeticorum confirmed that this rare skin complication occurs predominantly in young women with Type 1 diabetes and other microvascular complications. Biopsies of necrobiotic lesions showed destruction of superficial nerve fibres by inflammatory tissue, which likely causes the sensory loss in lesions that is pathognomonic of the condition. Read More

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http://dx.doi.org/10.1111/dme.13901DOI Listing
January 2019
3 Reads

High rates of atherogenic dyslipidemia, β-cell function loss, and microangiopathy among Turkish migrants with T2DM.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):716-720. Epub 2018 Nov 24.

Division of Cardiology, Cliniques universitaires St-Luc and Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Brussels, Belgium.

Aims: Non-Caucasian migrants require dedicated approaches in diabetes management due to specific genetic; socio-cultural; demographic and anthropological determinants. Documenting such phenotypes allows for better understanding unmet needs and management priorities.

Methods: This age- and sex-adjusted case-control (1:6 ratio) study compared 56 T2DM Turkish migrants (70% males) resident in Belgium [Tu] with 336 T2DM Caucasians [Ca], all benefiting from state-funded healthcare. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18714021183056
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http://dx.doi.org/10.1016/j.dsx.2018.11.049DOI Listing
November 2018
6 Reads

Ethnicity and diabetes complications in Sudanese population: The need for further genetic population testing.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):430-433. Epub 2018 Oct 11.

Department of Pathology, Faculty of Medicine, University of Medical Sciences and Technology, Khartoum, Sudan.

Background: The aim of the present study was to assess whether there is an association between ethnicity and the high prevalence of diabetes complications in Sudan.

Methods: This was cross-sectional hospital-based study with 316 individuals with diabetes conducted in Khartoum state, Sudan. A questionnaire was used to collect demographic information. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.10.017DOI Listing
October 2018
1 Read

Correlation between basal metabolic rate, visceral fat and insulin resistance among type 2 diabetes mellitus with peripheral neuropathy.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):344-348. Epub 2018 Oct 10.

Department of General Medicine, Dr. T.M.A Pai Hospital, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. Electronic address:

Background: Basal Metabolic Rate (BMR) means the amount of energy utilized by body in physical and psychological resting rate, after a night sleep, awake without any previous physical activity post meal (10 h after last meal) & neutral environment. In people with type 2 diabetes mellitus (T2DM) there is an increase in BMR which is said to be associated with the level of glycaemic control. So, the objective of the study was to find out the correlation between BMR, Insulin resistance and Visceral fat in T2DM with peripheral neuropathy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18714021183040
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http://dx.doi.org/10.1016/j.dsx.2018.10.005DOI Listing
October 2018
10 Reads

[Relation between sexual dysfunction and metabolic syndrome].

Orv Hetil 2019 Jan;160(3):98-103

Egészségfejlesztési és Népegészségtani Tanszék, Pécsi Tudományegyetem, Egészségtudományi Kar Pécs.

The prevalence of the metabolic syndrome, type 2 diabetes mellitus, cardiovascular diseases, obesity and depression have increased during the recent years. As the sexual dysfunction is also frequent, we aimed to search for the associations between sexual dysfunction and the metabolic syndrome and its components, respectively, by reviewing the literature. The clinical and biochemical components of the metabolic syndrome included cardiovascular disease, type 2 diabetes mellitus, visceral obesity and depression, furthermore, insulin resistance, atherogenic lipid profile, hypogonadism, chronic systemic inflammation and endothelial dysfunction were all demonstrated to affect adversely the sexual function. Read More

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https://www.akademiai.com/doi/10.1556/650.2019.31235
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http://dx.doi.org/10.1556/650.2019.31235DOI Listing
January 2019
6 Reads

The role of dietary non-heme iron load and peripheral nerve inflammation in the development of peripheral neuropathy (PN) in obese non-diabetic leptin-deficient ob/ob mice.

Neurol Res 2019 Jan 13:1-13. Epub 2019 Jan 13.

b Institute of Anatomy , University of Leipzig , Leipzig , Germany.

Introduction: Here, we investigated inflammatory signs of peripheral nerves in leptin-deficient obese ob/ob mice and the modulating effects of the exogenous iron load.

Methods: Ob/ob and ob/+ control mice were fed with high, standard, or low iron diet for four months.

Results: We found intraepidermal nerve fiber degeneration in foot skin and low-grade neuropathic abnormalities including mildly slowed motor and compound sensory nerve conduction velocities and low-grade macrophage and T-cell infiltration without overt neuropathology in sciatic nerves of all ob/ob mice. Read More

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https://www.tandfonline.com/doi/full/10.1080/01616412.2018.1
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http://dx.doi.org/10.1080/01616412.2018.1564191DOI Listing
January 2019
4 Reads

Combined heart and liver transplantation: State of knowledge and outlooks.

Clin Res Hepatol Gastroenterol 2019 Jan 8. Epub 2019 Jan 8.

Cardio-thoracic surgery department, hôpital de la Pitié-Salpêtrière (AP-HP), 47-83, boulevard de l'Hôpital, 75013 Paris, France.

Various types of liver impairment have been described in patients with end-stage heart failure who are awaiting heart transplantation. The liver impairment may be severe, characterized by a high model for end-stage liver disease (MELD) Score and/or the presence of ascites, both of which are associated with a high risk of failure after single heart transplantation. A liver function assessment is therefore necessary before registration on the heart transplant list, moreover in case of long-developing heart failure, such as with congenital heart disease or in the presence of risk factors for chronic liver disease including excessive alcohol consumption, metabolic syndrome or chronic viral hepatitis B or C. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22107401183017
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http://dx.doi.org/10.1016/j.clinre.2018.08.009DOI Listing
January 2019
4 Reads

Atherogenic Index in Type 2 Diabetes and Its Relationship with Chronic Microvascular Complications.

Int J Endocrinol 2018 29;2018:1765835. Epub 2018 Nov 29.

Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.

Objective: This study was designed to investigate risk factors related to atherogenic index of plasma (AIP), as well as the relationship between AIP and chronic microvascular complications in patients with type 2 diabetes (T2DM).

Methods: This study included 2523 patients with T2DM who had not been treated with lipid-lowering drugs and were admitted to the Department of Endocrinology at Zhongnan Hospital, Wuhan University, during the period from January 2015 to February 2018. Anthropometric indicators were measured after overnight fasting. Read More

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https://www.hindawi.com/journals/ije/2018/1765835/
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http://dx.doi.org/10.1155/2018/1765835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304911PMC
November 2018
7 Reads

Mitochondrial Neurogastrointestinal Encephalomyopathy: Into the Fourth Decade, What We Have Learned So Far.

Front Genet 2018 21;9:669. Epub 2018 Dec 21.

Molecular and Clinical Sciences Research Institute, St George's, University of London, London, United Kingdom.

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an ultra-rare metabolic autosomal recessive disease, caused by mutations in the nuclear gene which encodes the enzyme thymidine phosphorylase. The resulting enzyme deficiency leads to a systemic accumulation of the deoxyribonucleosides thymidine and deoxyuridine, and ultimately mitochondrial failure due to a progressive acquisition of secondary mitochondrial DNA (mtDNA) mutations and mtDNA depletion. Clinically, MNGIE is characterized by gastrointestinal and neurological manifestations, including cachexia, gastrointestinal dysmotility, peripheral neuropathy, leukoencephalopathy, ophthalmoplegia and ptosis. Read More

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https://www.frontiersin.org/article/10.3389/fgene.2018.00669
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http://dx.doi.org/10.3389/fgene.2018.00669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309918PMC
December 2018
4 Reads

Coaching of lifestyle recommendations improves sensory neurophysiological parameters in neuropathies related to glycemic disorder or metabolic syndrome. A pilot study.

Neurophysiol Clin 2019 Feb 4;49(1):59-67. Epub 2019 Jan 4.

EA 4391, Faculté de médecine de Créteil, Université Paris Est Créteil, 94010 Créteil, France; Service de neurologie, Groupe hospitalier Henri-Mondor, Centre hospitalier universitaire Henri-Mondor, Assistance publique-Hôpitaux de Paris, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address:

Objectives: Metabolic abnormalities, such as, glycemic disorders and metabolic syndrome (GDMS) are one of the main causes of peripheral neuropathies. The objective of this study was to evaluate the impact of adding specific coaching care (CC) to standard care (SC) of therapeutic education based on lifestyle recommendations for neuropathies associated with GDMS.

Methods: This prospective randomized study included two groups of four patients (SC vs. Read More

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http://dx.doi.org/10.1016/j.neucli.2018.12.004DOI Listing
February 2019
2 Reads

Management of people with Type 2 diabetes shared between a specialized outpatient clinic and primary health care is noninferior to management in a specialized outpatient clinic: a randomized, noninferiority trial.

Diabet Med 2019 Jan 6. Epub 2019 Jan 6.

Clinical Metabolic Physiology, Steno Diabetes Center Copenhagen, University of Copenhagen, Gentofte.

Aim: To evaluate whether management of people with Type 2 diabetes shared between a specialized outpatient clinic and primary health care has noninferior HbA outcomes compared with mono-sectorial management in a specialized outpatient clinic.

Methods: A randomized controlled, noninferiority study. People with moderate hyperglycaemia, hypertension and/or incipient complications were eligible for the study. Read More

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http://dx.doi.org/10.1111/dme.13896DOI Listing
January 2019

Suppression Failure of Cortisol Secretion by Dexamethasone May Occur in Glucagon-like Peptide-1 Receptor Agonist-treated Patients with Diabetic Autonomic Neuropathy.

Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan.

Two diabetic women (case 1, 75 years old; case 2, 49 years old) being treated with GLP-1 receptor agonists (GLP-1 RAs) showed no suppression of cortisol secretion on a dexamethasone suppression test (DST). However, its secretion was suppressed after switching from GLP-1 RAs to insulin. We also checked the cortisol secretion by a DST in five consecutive inpatients (case 3-7) being treated with GLP-1 RAs. Read More

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http://dx.doi.org/10.2169/internalmedicine.1585-18DOI Listing
December 2018
1 Read

A shared comparison of diabetes mellitus and neurodegenerative disorders.

J Cell Biochem 2018 Dec 19. Epub 2018 Dec 19.

Triplex Consulting, Northampton, Massachusetts.

Diabetes mellitus (DM), one of the most prevalent metabolic diseases in the world population, is associated with a number of comorbid conditions including obesity, pancreatic endocrine changes, and renal and cardio-cerebrovascular alterations, coupled with peripheral neuropathy and neurodegenerative disease, some of these disorders are bundled into metabolic syndrome. Type 1 DM (T1DM) is an autoimmune disease that destroys the insulin-secreting islet cells. Type 2 DM (T2DM) is diabetes that is associated with an imbalance in the glucagon/insulin homeostasis that leads to the formation of amyloid deposits in the brain, pancreatic islet cells, and possibly in the kidney glomerulus. Read More

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http://dx.doi.org/10.1002/jcb.28094DOI Listing
December 2018
3.263 Impact Factor

Can we link foot ulcer with risk factors in diabetics? A study in a tertiary care hospital.

Pak J Med Sci 2018 Nov-Dec;34(6):1375-1380

Zohaib Abbas Khan, Director technical (Add), Drug Testing Laboratory, Punjab, Rawalpindi.

Objective: Although many studies worldwide explained the risk factors for developing Diabetic Foot Ulceration (DFU), little has been done to assess medical factors in DFU formation and link them in patients of Pakistan. This study aimed to link the DFU with different risk factors.

Methods: This descriptive cross-sectional retrospective study was conducted in Diabetes Endocrine and Metabolic Centre / Post Graduate Medical Institute / Lahore General Hospital. Read More

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http://dx.doi.org/10.12669/pjms.346.16199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290204PMC
December 2018
1 Read

Peripheral nervous system involvement in lymphomas.

J Peripher Nerv Syst 2018 Dec 16. Epub 2018 Dec 16.

Hematology and Clinical Immunology Unit, Department of Medicine, University of Padova, Padova, Italy.

The peripheral nervous system may be involved at any stage in the course of lymphoproliferative diseases. The different underlying mechanisms include neurotoxicity secondary to chemotherapy, direct nerve infiltration (neurolymphomatosis), infections, immune-mediated, paraneoplastic or metabolic processes and nutritional deficiencies. Accordingly, the clinical features are heterogeneous and depend on the localization of the damage (ganglia, roots, plexi, and peripheral nerves) and on the involved structures (myelin, axon, and cell body). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jns.12295
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http://dx.doi.org/10.1111/jns.12295DOI Listing
December 2018
5 Reads
2.758 Impact Factor

Genetic variants in DNMT1 and the risk of cardiac autonomic neuropathy in women with type 1 diabetes.

J Diabetes Investig 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Carbohydrates and Radioimuneassays (LIM-18), Clinical Hospital, Medical School, University of Sao Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil.

Aims/introduction: Epigenetics participate in the pathogenesis of metabolic memory, a situation in which hyperglycemia exerts prolonged deleterious effects even after its normalization. We tested the hypothesis that genetic variants in an epigenetic gene could predispose to diabetes complications.

Material And Methods: We assessed the frequency of five single-nucleotide polymorphisms in the gene encoding deoxyribonucleic acid methytransferase 1 (DNMT1; rs8112895, rs7254567, rs11085721, rs17291414 and rs10854076), and their associations with diabetic kidney disease, retinopathy, distal polyneuropathy and autonomic cardiovascular neuropathy in 359 individuals with long-term type 1 diabetes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdi.12988
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http://dx.doi.org/10.1111/jdi.12988DOI Listing
December 2018
9 Reads

Late adult-onset adrenomyeloneuropathy evolving with atypical severe frontal lobe syndrome: Importance of neuroimaging.

Radiol Case Rep 2019 Mar 5;14(3):309-314. Epub 2018 Dec 5.

Department of Medical, Surgical, Neurological, Metabolic Sciences, and Aging, 2nd Division of Neurology, Center for Rare Diseases and InterUniversity Center for Research in Neurosciences, University of Campania "Luigi Vanvitelli", Via Sergio Pansini, 80131 Naples, Italy.

X-linked adrenoleukodystrophy (X-ALD) is a rare inherited metabolic disease affecting the nervous system and the adrenal glands. It is caused by a mutation of the gene, resulting in the impaired degradation of very long-chain fatty acids and their subsequent accumulation in several organs and tissues. X-ALD is notable for its high phenotypical variability, that includes isolated adrenocortical insufficiency, slowly progressive myelopathy with paraparesis, ataxia, and peripheral neuropathy to severe childhood cerebral forms. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282458PMC
March 2019
1 Read

Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications.

J Diabetes Res 2018 12;2018:5205126. Epub 2018 Nov 12.

Department of Internal Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.

The prevalence of diabetes is steadily rising, and once it occurs, it can cause multiple complications with a negative impact on the whole organism. Complications of diabetes may be macrovascular: such as stroke and ischemic heart disease as well as peripheral vascular and microvascular diseases-retinopathy, nephropathy, and neuropathy. Key factors that cause cardiovascular disease in people with diabetes include hyperglycemia, dyslipidemia, obesity, insulin resistance, inflammation, hypertension, autonomic dysfunction, and decreased vascular response capacity. Read More

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http://dx.doi.org/10.1155/2018/5205126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260408PMC
November 2018
3 Reads

The LKB1-AMPK and mTORC1 Metabolic Signaling Networks in Schwann Cells Control Axon Integrity and Myelination: Assembling and upholding nerves by metabolic signaling in Schwann cells.

Authors:
Bogdan Beirowski

Bioessays 2019 Jan 11;41(1):e1800075. Epub 2018 Dec 11.

Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, 14203, USA.

The Liver kinase B1 with its downstream target AMP activated protein kinase (LKB1-AMPK), and the key nutrient sensor mammalian target of rapamycin complex 1 (mTORC1) form two signaling systems that coordinate metabolic and cellular activity with changes in the environment in order to preserve homeostasis. For example, nutritional fluctuations rapidly feed back on these signaling systems and thereby affect cell-specific functions. Recent studies have started to reveal important roles of these strategic metabolic regulators in Schwann cells for the trophic support and myelination of axons. Read More

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http://dx.doi.org/10.1002/bies.201800075DOI Listing
January 2019
2 Reads

Giant Axonal Neuropathy: Clinical, Radiological, and Genetic Features.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):304-308

Department of Pediatric Neurosciences, Bai Jerbai Wadia Hospital for Children, Mumbai, India.

Introduction: Giant axonal neuropathy (GAN) is an inherited neurodegenerative disorder caused by mutations in the GAN gene. It affects both the central and peripheral nervous systems. We discuss clinical, electrophysiological, radiological and genetic features in three new unrelated patients with GAN. Read More

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http://dx.doi.org/10.4103/aian.AIAN_82_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238561PMC
December 2018
14 Reads

Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice.

PLoS One 2018 10;13(12):e0208596. Epub 2018 Dec 10.

National Research Council-CNR, Institute of Cell Biology and Neurobiology, Rome, Italy.

There is a growing interest on the role of autophagy in diabetes pathophysiology, where development of neuropathy is one of the most frequent comorbidities. We have previously demonstrated that neuropathic pain after nerve damage is exacerbated in autophagy-defective heterozygous Ambra1 mice. Here, we show the existence of a prediabetic state in Ambra1 mice, characterized by hyperglycemia, intolerance to glucose and insulin resistance. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208596PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287902PMC
December 2018
5 Reads
3.234 Impact Factor

Cobalamin (Vitamin B12) Induced a Shift in Microbial Composition and Metabolic Activity in an Colon Simulation.

Front Microbiol 2018 16;9:2780. Epub 2018 Nov 16.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, China.

Cobalamin deficiency is believed to be related to disturbances in cell division, neuropathy, nervous system disease and pernicious anemia. Elderly people are usually advised to supplement their diets with cobalamin. As cobalamin has several forms, the effects of different forms of cobalamin on gut microbiota were investigated in this study. Read More

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http://dx.doi.org/10.3389/fmicb.2018.02780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250798PMC
November 2018
1 Read

Discovery and evaluation of novel FAAH inhibitors in neuropathic pain model.

Bioorg Med Chem Lett 2019 Jan 24;29(2):238-243. Epub 2018 Nov 24.

Drug Discovery Facility - Pune, Advinus Therapeutics Limited, Head Office: Block No. 21 & 22, Phase II, Peenya Industrial Area, Bangalore 560058, India.

Conceptual design and modification of urea moiety in chemotype PF-3845/04457845, the bench marking irreversible inhibitor of fatty acid amide hydrolase (FAAH), led to discovery of a novel nicotinamide-based lead 12a having reversible mechanism of action. Focused SAR around the pyridine heterocycle (Ar) in 12a (Tables 1 and 2) resulted into four shortlisted compounds, (-)-12a, (-)-12i, (-)-12l-m. The required (-)-enantiomers were obtained via diastereomeric resolution of a novel chiral dissymmetric intermediate 15. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183092
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http://dx.doi.org/10.1016/j.bmcl.2018.11.048DOI Listing
January 2019
9 Reads

Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: Presentations, causes and treatment strategies.

Authors:
Sherifa A Hamed

Expert Rev Clin Pharmacol 2018 Dec 2. Epub 2018 Dec 2.

a Department of Neurology and Psychiatry , Assiut University Hospital , Assiut , Egypt.

Introduction: Uremic syndrome of chronic kidney disease (CKD) is a term used to describe clinical, metabolic and hormonal abnormalities associated with progressive kidney failure. It is a rapidly growing public health problem worldwide. Nervous system complications occur in every patient with uremic syndrome of CKD. Read More

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http://dx.doi.org/10.1080/17512433.2019.1555468DOI Listing
December 2018
2 Reads

SIV-Induced Immune Activation and Metabolic Alterations in the Dorsal Root Ganglia During Acute Infection.

J Neuropathol Exp Neurol 2019 Jan;78(1):78-87

Department of Molecular and Comparative Pathobiology.

Human immunodeficiency virus-associated sensory neuropathy (HIV-SN) remains a frequent neurologic complication of HIV infection. Little is known about alterations in the peripheral nervous system during the early stages of HIV, a time when neuroprotective interventions may be most beneficial. We performed Nanostring gene expression analysis on lumbar dorsal root ganglia (DRG) from 6 simian immunodeficiency virus (SIV)-infected pigtailed macaques killed at 7 days post-inoculation and 8 uninfected controls. Read More

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http://dx.doi.org/10.1093/jnen/nly111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289222PMC
January 2019

Peripheral nerve disease.

Authors:
Gita Ramdharry

Handb Clin Neurol 2018 ;159:403-415

Faculty of Health, Social Care and Education, Kingston University and Queen Square MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, United Kingdom. Electronic address:

Polyneuropathies are common neurologic disorders affecting the peripheral nerves. There are a number of causes of damage to these structures, such as genetic and metabolic factors, autoimmune disorders, infection, drug or environmental toxicity, and malignancy. Motor and sensory impairments are commonly encountered in these conditions, leading to altered balance and gait with increased risk of falling. Read More

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http://dx.doi.org/10.1016/B978-0-444-63916-5.00026-4DOI Listing
January 2018

Calcimimetic restores diabetic peripheral neuropathy by ameliorating apoptosis and improving autophagy.

Cell Death Dis 2018 Nov 26;9(12):1163. Epub 2018 Nov 26.

Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Decreased AMPK-eNOS bioavailability mediates the development of diabetic peripheral neuropathy (DPN) through increased apoptosis and decreased autophagy activity in relation to oxidative stress. Schwann cells are responsible for maintaining structural and functional integrity of neurons and for repairing damaged nerves. We evaluated the neuro-protective effect of cinacalcet on DPN by activating the AMPK-eNOS pathway using db/db mice and human Schwann cells (HSCs). Read More

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http://www.nature.com/articles/s41419-018-1192-7
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http://dx.doi.org/10.1038/s41419-018-1192-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255917PMC
November 2018
11 Reads

Vertical displacement of the centre of mass during walking in people with diabetes and diabetic neuropathy does not explain their higher metabolic cost of walking.

J Biomech 2019 Jan 20;83:85-90. Epub 2018 Nov 20.

Research Centre for Musculoskeletal Science & Sports Medicine, School of Healthcare Science, Faculty of Science & Engineering, Manchester Metropolitan University, UK. Electronic address:

People with diabetes display biomechanical gait alterations compared to controls and have a higher metabolic cost of walking (CoW), but it remains unknown whether differences in the vertical displacement of the body centre of mass (CoM) may play a role in this higher CoW. The aim of this study was to investigate vertical CoM displacement (and step length as a potential underpinning factor) as an explanatory factor in the previously observed increased CoW with diabetes. Thirty-one non-diabetic controls (Ctrl); 22 diabetic patients without peripheral neuropathy (DM) and 14 patients with moderate/severe Diabetic Peripheral Neuropathy (DPN), underwent gait analysis using a motion analysis system and force plates while walking at a range of matched speeds between 0. Read More

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http://dx.doi.org/10.1016/j.jbiomech.2018.11.027DOI Listing
January 2019
1 Read

0.075% capsaicin lotion for the treatment of painful diabetic neuropathy: A randomized, double-blind, crossover, placebo-controlled trial.

J Clin Neurosci 2018 Nov 22. Epub 2018 Nov 22.

Center of Excellence for Diabetic Foot Care, Thammasat University Hospital, Pathumthani, Thailand; Department of Nursing, Thammasat University Hospital, Pathumthani, Thailand.

Objective: A randomized, double-blinded, crossover, placebo controlled trial was conducted to evaluate the efficacy and safety of 0.075% capsaicin lotion for treating painful diabetic neuropathy (PDN).

Patients And Methods: PDN subjects were randomized to receive 0. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.11.036DOI Listing
November 2018
2 Reads

Emerging role of Unfolded Protein Response (UPR) mediated proteotoxic apoptosis in diabetes.

Life Sci 2019 Jan 22;216:246-258. Epub 2018 Nov 22.

Herbal Research Laboratory, Food, Drug & Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan 31, M.G Marg, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Toxicology Research, Lucknow 226001, Uttar Pradesh, India. Electronic address:

Endoplasmic reticulum (ER) is a crucial single membrane organelle that acts as a quality control system for cellular proteins as it is intricately involved in their synthesis, folding and trafficking to the respective targets. Type 2 diabetes is characterized by enhanced blood glucose level that promotes insulin resistance and hampers cellular glucose metabolism. Hyperglycemia provokes mitochondrial ROS production and glycation of proteins which exert a tremendous load on ER for conventional refolding of misfolded/unfolded and nascent proteins that perturb ER homeostasis resulting in apoptotic cell death. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.11.041DOI Listing
January 2019
8 Reads

Modeling Diabetic Corneal Neuropathy in a 3D In Vitro Cornea System.

Sci Rep 2018 Nov 23;8(1):17294. Epub 2018 Nov 23.

Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.

Diabetes mellitus is a disease caused by innate or acquired insulin deficiency, resulting in altered glucose metabolism and high blood glucose levels. Chronic hyperglycemia is linked to development of several ocular pathologies affecting the anterior segment, including diabetic corneal neuropathy and keratopathy, neovascular glaucoma, edema, and cataracts leading to significant visual defects. Due to increasing disease prevalence, related medical care costs, and visual impairment resulting from diabetes, a need has arisen to devise alternative systems to study molecular mechanisms involved in disease onset and progression. Read More

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http://dx.doi.org/10.1038/s41598-018-35917-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251923PMC
November 2018
18 Reads

Madelung Disease: Analysis of Clinicopathological Experience in Taipei Veterans General Hospital.

Ann Plast Surg 2019 Jan;82(1S Suppl 1):S66-S71

From the Division of Plastic Surgery, Department of Surgery, and.

Background: The main feature of Madelung disease (MD), a rare condition, is the growth of adipose tissue without a capsule. Usually, this disease is known for its prominent features with fat deposition around the neck, shoulder, back, or chest wall. Clinically, the patient is likely to exhibit alcohol, neuropathy, and metabolic disorders; however, no clear cause has been confirmed. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001719DOI Listing
January 2019
11 Reads

A Case of Fulminant Type 1 Diabetes with Gastric and Urinary Retention.

Diabetes Ther 2019 Feb 20;10(1):291-298. Epub 2018 Nov 20.

First Endocrinology Department, Shengjing Hospital Affiliated to China Medical University, Shenyang, People's Republic of China.

Fulminant type 1 diabetes (fT1D) is a severe subtype of type 1 diabetes which progresses rapidly with islet cells destroyed almost completely within a short period of time. It is often characterized by flu-like or gastrointestinal symptoms at the onset with negative islet-associated autoantibodies, resulting in an absolute deficiency of endogenous insulin secretion. Poor prognosis can be caused by the significantly higher incidence of metabolic disorders (such as severe ion disorders and elevated serum pancreatic enzymes), acute and chronic complications if not diagnosed and treated in a timely manner. Read More

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http://dx.doi.org/10.1007/s13300-018-0533-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349281PMC
February 2019
15 Reads

POLG-related disorders and their neurological manifestations.

Nat Rev Neurol 2019 Jan;15(1):40-52

Mitochondrial DNA Replication Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Durham, NC, USA.

The POLG gene encodes the mitochondrial DNA polymerase that is responsible for replication of the mitochondrial genome. Mutations in POLG can cause early childhood mitochondrial DNA (mtDNA) depletion syndromes or later-onset syndromes arising from mtDNA deletions. POLG mutations are the most common cause of inherited mitochondrial disorders, with as many as 2% of the population carrying these mutations. Read More

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http://www.nature.com/articles/s41582-018-0101-0
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http://dx.doi.org/10.1038/s41582-018-0101-0DOI Listing
January 2019
11 Reads

Surgical options for meralgia paresthetica: long-term outcomes in 13 cases.

Br J Neurosurg 2018 Nov 19:1-4. Epub 2018 Nov 19.

c Department of Neurosurgery , Eskisehir State Hospital , Eskisehir , Turkey.

Background: Meralgia paresthetica is an entrapment neuropathy of the lateral femoral cutaneous nerve that may cause paresthesias, pain, and sensory loss of the anterior and lateral thigh. Treatment is primarily medical. Surgery is an option for patients who do not respond to medical treatments. Read More

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https://www.tandfonline.com/doi/full/10.1080/02688697.2018.1
Publisher Site
http://dx.doi.org/10.1080/02688697.2018.1538480DOI Listing
November 2018
25 Reads
0.950 Impact Factor