3,033 results match your criteria Metabolic Neuropathy


Impaired fat oxidation during exercise in Long-Chain Acyl-CoA Dehydrogenase Deficiency patients and effect of IV-glucose.

J Clin Endocrinol Metab 2019 Apr 16. Epub 2019 Apr 16.

Copenhagen Neuromuscular Center, Department of Neurology, Rigshospitalet, Copenhagen Denmark.

Context: Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) affects oxidation of long-chain fatty acids (FAO) and is associated with risk of metabolic crises and episodic rhabdomyolysis.

Case Description: We present two patients with LCHADD. Patient 1 (male, 26 years) was severely affected by muscle weakness and neuropathy. Read More

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http://dx.doi.org/10.1210/jc.2019-00453DOI Listing

[Diagnosis, treatment and monitoring of diabetic eye disease (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Universitäts-Augenklinik, Medizinische Universität Graz, Graz, Österreich.

Diabetes mellitus can cause diabetic retinopathy, diabetic macular edema, optic neuropathy, cataract or dysfunction of the eye muscles. The incidence of these defects correlates with disease duration and quality of metabolic control. Recommendations of the Austrian Diabetes Association for diagnosis, therapeutic procedures and requirements for adequate follow-up depending on stage of diabetic eye disease are summarized. Read More

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http://dx.doi.org/10.1007/s00508-019-1445-1DOI Listing
April 2019
1 Read

Biallelic variants in AGTPBP1, involved in tubulin deglutamylation, are associated with cerebellar degeneration and motor neuropathy.

Eur J Hum Genet 2019 Apr 11. Epub 2019 Apr 11.

Department of Genetic and Metabolic Diseases, Hadassah-Hebrew University Medical Center, 9112001, Jerusalem, Israel.

The ATP/GTP-Binding Protein 1 (AGTPBP1) gene (OMIM *606830) catalyzes deglutamylation of polyglutamylated proteins, and its deficiency manifests by cerebellar ataxia and peripheral neuropathy in mice and lower motor neuron-like disease in sheep. In the mutant mice, cerebellar atrophy due to Purkinje cell degeneration is observed, likely due to increased tubulin polyglutamylation in affected brain areas. We report two unrelated individuals who presented with early onset cerebellar atrophy, developmental arrest with progressive muscle weakness, and feeding and respiratory difficulties, accompanied by severe motor neuronopathy. Read More

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http://dx.doi.org/10.1038/s41431-019-0400-yDOI Listing

Small-fiber neuropathy definition, diagnosis, and treatment.

Neurol Sci 2019 Apr 9. Epub 2019 Apr 9.

Laboratory of the Mosaic of Autoimmunity, Federal State Budget Educational Institution of Higher Education "St. Petersburg State University", University Emb., 7-9, Saint-Petersburg, Russia, 199034.

In the last 30 years, improvement of diagnostic methods enabled routine evaluation of small A-delta and C nerve fibers impairment, which results with the clinical condition known as a small-fiber neuropathy (SFN). This syndrome develops as a result of metabolic, toxic, immune-mediated, or genetic factors. The main clinical features include neuropathic pain and autonomic disturbance, which are occasionally disclaimed due to outstanding fatigue, daily performance decline, anxiety, and depression. Read More

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http://dx.doi.org/10.1007/s10072-019-03871-xDOI Listing
April 2019
1 Read

Diabetes and heart failure: Is it hyperglycemia or hyperinsulinemia?

Curr Vasc Pharmacol 2019 Apr 8. Epub 2019 Apr 8.

Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University of Tübingen and Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen. Germany.

The cardiac effects of exogenously administered insulin for the treatment of diabetes (DM) have recently attracted much attention. In particular, it has been questioned whether insulin is the appropriate treatment for patients with type 2 diabetes mellitus (T2DM) and heart failure. While several old and some new studies suggested that insulin treatment has beneficial effects for the heart, recent observational studies indicate associations of insulin treatment with increased risk of developing or worsening of a pre-existing heart failure and higher mortality rates. Read More

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http://dx.doi.org/10.2174/1570161117666190408164326DOI Listing
April 2019
1 Read

Evaluating All Potential Oral Complications of Diabetes Mellitus.

Front Endocrinol (Lausanne) 2019 18;10:56. Epub 2019 Feb 18.

Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit, Amsterdam, Netherlands.

Diabetes mellitus (DM) is associated with several microvascular and macrovascular complications, such as retinopathy, nephropathy, neuropathy, and cardiovascular diseases. The pathogenesis of these complications is complex, and involves metabolic and hemodynamic disturbances, including hyperglycemia, insulin resistance, dyslipidemia, hypertension, and immune dysfunction. These disturbances initiate several damaging processes, such as increased reactive oxygen species (ROS) production, inflammation, and ischemia. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2019.00056
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http://dx.doi.org/10.3389/fendo.2019.00056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439528PMC
February 2019
7 Reads

Thyroidectomy Complications in Patients with Diabetes Mellitus.

Otolaryngol Head Neck Surg 2019 Apr 9:194599819835793. Epub 2019 Apr 9.

1 Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA.

Objective: To (1) analyze postoperative thyroidectomy outcomes in patients with diabetes mellitus (DM), who are prone to deleterious effects of glucose dysmetabolism, and (2) apply findings to optimize perioperative management of diabetics requiring thyroid surgery.

Study Design: Retrospective database analysis.

Setting: University hospital. Read More

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http://dx.doi.org/10.1177/0194599819835793DOI Listing
April 2019
1 Read

Visual loss post Ross procedure in an adolescent with newly diagnosed Mucopolysaccharidosis Type II.

Ann Thorac Surg 2019 Apr 3. Epub 2019 Apr 3.

Congenital Cardiology Directorate, Royal Brompton & Harefield NHS Trust, Sydney Street, London, UK. Electronic address:

Perioperative visual loss is a rare but serious complication after cardiac surgery. Despite this, its etiology is not fully understood and there is no consensus on the optimal management of this condition. A 15-year-old male developed severe visual impairment attributed to non-arteritic anterior ischemic optic neuropathy after a Ross aortic root replacement procedure. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.03.011DOI Listing
April 2019
2 Reads

Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8 T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness.

Immunity 2019 Mar 23. Epub 2019 Mar 23.

T Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany. Electronic address:

Patients with the neurological disorder HSAN-I suffer frequent infections, attributed to a lack of pain sensation and failure to seek care for minor injuries. Whether protective CD8 T cells are affected in HSAN-I patients remains unknown. Here, we report that HSAN-I-associated mutations in serine palmitoyltransferase subunit SPTLC2 dampened human T cell responses. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.03.005DOI Listing

Metabolomic signature of type 1 diabetes-induced sensory loss and nerve damage in diabetic neuropathy.

J Mol Med (Berl) 2019 Apr 4. Epub 2019 Apr 4.

Institute of Pharmacology, Heidelberg University, Im Neuenheimer Feld 366, D-69120, Heidelberg, Germany.

Diabetic-induced peripheral neuropathy (DPN) is a highly complex and frequent diabetic late complication, which is manifested by prolonged hyperglycemia. However, the molecular mechanisms underlying the pathophysiology of nerve damage and sensory loss remain largely unclear. Recently, alteration in metabolic flux has gained attention as a basis for organ damage in diabetes; however, peripheral sensory neurons have not been adequately analyzed with respect to metabolic dysfunction. Read More

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http://dx.doi.org/10.1007/s00109-019-01781-1DOI Listing
April 2019
4 Reads

AMPK in microvascular complications of diabetes and the beneficial effects of AMPK activators from plants.

Phytomedicine 2018 Dec 24. Epub 2018 Dec 24.

Department of Molecular Nutrition, CSIR-Central Food Technological Research Institute, Mysuru, Karnataka 570 020, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-CFTRI campus, Mysuru, Karnataka 570 020, India. Electronic address:

Background: Diabetes mellitus is a multifactorial disorder with the risk of micro- and macro-vascular complications. High glucose-induced derangements in metabolic pathways are primarily associated with the initiation and progression of secondary complications namely, diabetic nephropathy, neuropathy, and retinopathy. Adenosine monophosphate-activated protein kinase (AMPK) has emerged as an attractive therapeutic target to treat various metabolic disorders including diabetes mellitus. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.031DOI Listing
December 2018

Vision Impairment in CKD Patients: Epidemiology, Mechanisms, Differential Diagnoses, and Prevention.

Am J Kidney Dis 2019 Mar 28. Epub 2019 Mar 28.

Singapore Eye Research Institute, Singapore National Eye Centre; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School. Electronic address:

Eyes and kidneys have numerous structural, developmental, physiologic, and pathogenic pathways in common, suggesting that many kidney and eye diseases may be interlinked. Studies suggest that the prevalence of eye diseases and vision impairment are higher among persons with end-stage kidney disease and earlier stages of chronic kidney disease (CKD) than in those without. Ocular morbidity in persons with CKD and end-stage kidney disease may be due to the following risk factors: (1) underlying conditions and risk factors for CKD such as diabetes or hypertension, (2) metabolic disorders associated with CKD, (3) uremia and anemia, and (4) CKD treatment. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.047DOI Listing
March 2019
5 Reads
5.900 Impact Factor

Methylglyoxal - An emerging biomarker for diabetes mellitus diagnosis and its detection methods.

Biosens Bioelectron 2019 May 8;133:107-124. Epub 2019 Mar 8.

School of Electrical & Electronics Engineering, SASTRA Deemed University, Thanjavur 613004, India; Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), SASTRA Deemed University, Thanjavur 613004, India. Electronic address:

Diabetes Mellitus (DM) is one among the supreme metabolic issues observed in history since 3000 BCE and has gained much interest recently due to the increasing number of diabetic cases every year. Glucose is considered as the most iconic biomarker for diabetes detection, and fluctuations in its levels are related to different stages of DM. However, methylglyoxal (MG) is evolving as a diabetes marker since it plays a significant role in biological processes Apart from DM, MG causes several metabolic irregularities like hypertension, neuropathy, nephropathy, oxidative stress. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.010DOI Listing
May 2019
1 Read

Impact of chrysin on the molecular mechanisms underlying diabetic complications.

J Cell Physiol 2019 Mar 27. Epub 2019 Mar 27.

Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.

Diabetes mellitus is a chronic metabolic disorder, resulting in high morbidity and mortality worldwide. Neuropathy, ocular diseases, kidney diseases, and cardiovascular disease are common complications of diabetes that threats the patient's life. Chrysin (CH), a natural flavonoid, has several pharmacological effects, including antioxidant, antiapoptotic, anti-inflammatory, and anticancer. Read More

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http://dx.doi.org/10.1002/jcp.28488DOI Listing
March 2019
2 Reads
3.839 Impact Factor

The neuropathic pain: An overview of the current treatment and future therapeutic approaches.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419838383

1 I.R.C.C.S. Centro Neurolesi Bonino Pulejo, Messina, Italy.

Neuropathic pain is characterized by abnormal hypersensitivity to stimuli (hyperalgesia) and nociceptive responses to non-noxious stimuli (allodynia). The conditions and the pathophysiological states that determine the onset of neuropathic pain are heterogeneous, such as metabolic disorders, neuropathy caused by viral infections, and autoimmune diseases affecting the central nervous system (CNS). Neuropathic pain in the general population is estimated to have a prevalence ranging between 3% and 17%. Read More

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http://dx.doi.org/10.1177/2058738419838383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431761PMC

Fetal chronic hypoxia and oxidative stress in diabetic pregnancy. Could fetal erythropoietin improve offspring outcomes?

Free Radic Biol Med 2019 Mar 18. Epub 2019 Mar 18.

Neonatal Research Unit, Health Research Institute La Fe, Valencia, Spain.

Oxidative stress is responsible for microvascular complications (hypertension, nephropathy, retinopathy, peripheral neuropathy) of diabetes, which during pregnancy increase both maternal and fetal complications. Chronic hypoxia and hyperglycemia result in increased oxidative stress and decreased antioxidant enzyme activity. However, oxidative stress induces also anti-oxidative reactions both in pregnant diabetes patients and in their fetuses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915849183264
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http://dx.doi.org/10.1016/j.freeradbiomed.2019.03.012DOI Listing
March 2019
6 Reads

The divergent roles of dietary saturated and monounsaturated fatty acids on nerve function in murine models of obesity.

J Neurosci 2019 Mar 18. Epub 2019 Mar 18.

Departments of Neurology, University of Michigan, Ann Arbor, MI 48109, USA

Neuropathy is the most common complication of prediabetes and diabetes and presents as distal-to-proximal loss of peripheral nerve function in the lower extremities. Neuropathy progression and disease severity in prediabetes and diabetes correlates with dyslipidemia in man and murine models of disease. Dyslipidemia is characterized by elevated levels of circulating saturated fatty acids (SFAs) that associate with the progression of neuropathy. Read More

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.3173-1
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http://dx.doi.org/10.1523/JNEUROSCI.3173-18.2019DOI Listing
March 2019
4 Reads

Uric Acid Levels Correlate with Sensory Nerve Function in Healthy Subjects.

Can J Neurol Sci 2019 Mar 18:1-5. Epub 2019 Mar 18.

Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine,University Health Network, University of Toronto,Toronto,Canada.

Background: High levels of uric acid (UA) are associated with various peripheral neuropathies. Furthermore, uric acid levels have been found to correlate with both the clinical and electrophysiological severity of diabetic sensorimotor polyneuropathy, mainly with sensory functions.

Objectives: To determine whether higher UA levels are associated negatively with nerve function in healthy subjects. Read More

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http://dx.doi.org/10.1017/cjn.2019.9DOI Listing
March 2019
1 Read

DNA polymerase-γ hypothesis in nucleoside reverse transcriptase-induced mitochondrial toxicity revisited: A potentially protective role for citrus fruit-derived naringenin?

Eur J Pharmacol 2019 Jun 12;852:159-166. Epub 2019 Mar 12.

Molecular and Clinical Pharmacology Research Laboratory, Department of Pharmacology, Discipline of Pharmaceutical, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Private Bag X5400, Durban 3629, South Africa. Electronic address:

Nucleoside reverse transcriptase inhibitors (NRTIs) form the backbone in combination antiretroviral therapy (cARVs). They halt chain elongation of the viral cDNA by acting as false substrates in counterfeit incorporation mechanism to viral RNA-dependent DNA polymerase. In the process genomic DNA polymerase as well as mitochondrial DNA (mtDNA) polymerase-γ (which has a much higher affinity for these drugs at therapeutic doses) are also impaired. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.03.017DOI Listing
June 2019
1 Read

The Role of Iron and Nerve Inflammation in Diabetes Mellitus Type 2-Induced Peripheral Neuropathy.

Neuroscience 2019 Mar 10;406:496-509. Epub 2019 Mar 10.

Institute of Anatomy, University of Leipzig, Liebigstr. 13, D-04103 Leipzig, Germany. Electronic address:

Peripheral diabetic neuropathy (PDN) is one of the most common complications of diabetes mellitus. Previous studies showed an association between dietary iron load and inflammation in the development of PDN in a rat model of type 1 diabetes (T1D). Here we investigated the role of iron and neural inflammation in development of PDN in a animal model of obesity and type 2 diabetes (T2D). Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.03.005DOI Listing
March 2019
1 Read

Relationship Between HbA1c And Capillary Blood Glucose Self-Monitoring In Type 2 Diabetics.

Rom J Intern Med 2018 Dec 1. Epub 2018 Dec 1.

School of Technology and Management, Polytechnic Institute of Viseu, Portugal.

Introduction: Diabetes Control and Complications Trial has established the importance of glycemic control in reducing the progression of retinopathy, nephropathy, and neuropathy in type 1 diabetics. There is little literature linking the frequency of glycemic monitoring with glycated hemoglobin A (HbA1c) in type 2 diabetics. The objectives were to assess the influence of glycemic self-monitoring on HbA1c in three groups of patients with type 2 diabetes (with insulin, with oral antidiabetics and with combination therapy). Read More

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http://content.sciendo.com/view/journals/rjim/ahead-of-print
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http://dx.doi.org/10.2478/rjim-2018-0043DOI Listing
December 2018
7 Reads

Is our treatment in type 1 diabetes mellitus (insulin therapy models, metabolic control) optimal for preventing cardiovascular autonomic neuropathy?

Endokrynol Pol 2019 Mar 7. Epub 2019 Mar 7.

Katedra i Klinika Chorób Metabolicznych, Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie, Poland.

Introduction: Long-term poor metabolic control promotes the occurrence of microvascular complications, such cardiovascular autonomic neuropathy and atherogenic hyperlipidaemia, which translates into increased mortality in patients with type 1 diabetes (T1DM).

Aims: To assess the prevalence of cardiovascular autonomic neuropathy (CAN) in patients with T1DM in relation to treatment method (continuous subcutaneous insulin infusion (CSII) versus multiple daily injections using pens (MDI)) and lipid control.

Material And Methods: The study group comprised 93 adults (60 women, 33 men), median age 31, with T1DM being treated in a local clinical centre in 2011-2015. Read More

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http://dx.doi.org/10.5603/EP.a2019.0011DOI Listing
March 2019
3 Reads

Recurrent acute liver failure associated with novel mutation: A case report.

World J Clin Cases 2019 Feb;7(4):494-499

The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai 201102, China.

Background: Pediatric recurrent acute liver failure (RALF) with recovery between episodes is rare. Causes include autoimmune disease, which may flare and subside; intermittent exposure to toxins, as with ingestions; and metabolic disorders, among them the fever-associated crises ascribed to biallelic mutations in , with RALF beginning in infancy. disease manifest with RALF, as known to date, includes central and peripheral neurologic and muscular morbidity (hepatocerebellar neuropathy syndrome). Read More

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http://dx.doi.org/10.12998/wjcc.v7.i4.494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397814PMC
February 2019
2 Reads

Ocular dysfunctions and toxicities induced by antiepileptic medications: Types, pathogenic mechanisms, and treatment strategies.

Authors:
Sherifa A Hamed

Expert Rev Clin Pharmacol 2019 Apr 20;12(4):309-328. Epub 2019 Mar 20.

a Department of Neurology and Psychiatry , Assiut University Hospital , Assiut , Egypt.

Introduction: Ocular dysfunctions and toxicities induced by antiepileptic drugs (AEDs) are rarely reviewed and not frequently received attention by treating physicians compared to other adverse effects (e.g. endocrinologic, cognitive and metabolic). Read More

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http://dx.doi.org/10.1080/17512433.2019.1591274DOI Listing
April 2019
8 Reads

Pancreatic kallikrein protects against diabetic retinopathy in KK Cg-A/J and high-fat diet/streptozotocin-induced mouse models of type 2 diabetes.

Diabetologia 2019 Mar 5. Epub 2019 Mar 5.

NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Metabolic Diseases Hospital & Institute of Endocrinology, Tianjin Medical University, Tianjin, 300070, China.

Aims/hypothesis: Many studies have shown that tissue kallikrein has effects on diabetic vascular complications such as nephropathy, cardiomyopathy and neuropathy, but its effects on diabetic retinopathy are not fully understood. Here, we investigated the retinoprotective role of exogenous pancreatic kallikrein and studied potential mechanisms of action.

Methods: We used KK Cg-A/J (KKAy) mice (a mouse model of spontaneous type 2 diabetes) and mice with high-fat diet/streptozotocin (STZ)-induced type 2 diabetes as our models. Read More

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http://dx.doi.org/10.1007/s00125-019-4838-9DOI Listing
March 2019
5 Reads

Levodopa-Induced Neuropathy: A Systematic Review.

Mov Disord Clin Pract 2019 Feb 8;6(2):96-103. Epub 2018 Nov 8.

Department of Neuroscience "Rita Levi Montalcini" University of Turin Torino Italy.

Background: Clinical, neurophysiological, and pathological evidence suggest an association between Parkinson's disease (PD) and peripheral neuropathy (PNP), with a possible causative role of levodopa metabolic products, such as homocysteine and methylmalonic acid.

Methods: We conducted a systematic review of studies reporting cases of PNP in l-dopa-treated PD patients indexed in PubMed between January 1990 and March 2018.

Results: We identified 38 articles reporting cases of PNP in PD patients treated with oral l-dopa or with l-dopa/carbidopa intestinal gel infusion (LCIG). Read More

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http://dx.doi.org/10.1002/mdc3.12688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384168PMC
February 2019
3 Reads

Cysteinyl-tRNA Synthetase Mutations Cause a Multi-System, Recessive Disease That Includes Microcephaly, Developmental Delay, and Brittle Hair and Nails.

Am J Hum Genet 2019 Mar 26;104(3):520-529. Epub 2019 Feb 26.

Department of Clinical Genetics, Erasmus Medical Center, University Medical Center, 3015 GD Rotterdam, the Netherlands.

Aminoacyl-tRNA synthetases (ARSs) are essential enzymes responsible for charging tRNA molecules with cognate amino acids. Consistent with the essential function and ubiquitous expression of ARSs, mutations in 32 of the 37 ARS-encoding loci cause severe, early-onset recessive phenotypes. Previous genetic and functional data suggest a loss-of-function mechanism; however, our understanding of the allelic and locus heterogeneity of ARS-related disease is incomplete. Read More

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http://dx.doi.org/10.1016/j.ajhg.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407526PMC
March 2019
1 Read

HbA1C Variability Is Strongly Associated With the Severity of Peripheral Neuropathy in Patients With Type 2 Diabetes.

Front Neurosci 2019 13;13:90. Epub 2019 Feb 13.

Department of Biological Science, National Sun Yat-Sen University, Kaohsiung, Taiwan.

Variability in HbA1c is associated with a higher risk of cardiovascular disease and microvascular complications in patients with type 2 diabetes. The present study evaluated the severity of somatic nerve dysfunction at different stages of chronic glycemic impairment, and its correlation with different cardio-metabolic parameters. The study was conducted on 223 patients with type 2 diabetes. Read More

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http://dx.doi.org/10.3389/fnins.2019.00090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381926PMC
February 2019
1 Read

Dietary fibers as emerging nutritional factors against diabetes: focus on the involvement of gut microbiota.

Crit Rev Biotechnol 2019 Jun 27;39(4):524-540. Epub 2019 Feb 27.

a Department of Food Science and Nutrition, National Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing , Zhejiang University , Hangzhou , PR China.

Diabetes mellitus (DM) increases the risk of cardiovascular diseases and other secondary complications, such as nephropathy, neuropathy, retinopathy, etc. The important risk factors for the pathogenesis of DM are aging, family history, sedentary lifestyle, unhealthy dietary habits, and obesity. Evidence from epidemiological studies also indicates that DM is characterized by specific alterations in the human gut microbiota (GM). Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2019.1
Publisher Site
http://dx.doi.org/10.1080/07388551.2019.1576025DOI Listing
June 2019
2 Reads

Bortezomib-induced aerobic glycolysis contributes to chemotherapy-induced painful peripheral neuropathy.

Mol Pain 2019 Jan-Dec;15:1744806919837429

1 Department of Neural and Pain Sciences, School of Dentistry, University of Maryland Baltimore, Baltimore, MD, USA.

Chemotherapy-induced painful peripheral neuropathy (CIPN) is the most common toxicity associated with widely used chemotherapeutics. CIPN is the major cause of dose reduction or discontinuation of otherwise life-saving treatment. Unfortunately, CIPN can persist in cancer survivors, which adversely affects their quality of life. Read More

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http://dx.doi.org/10.1177/1744806919837429DOI Listing
February 2019
1 Read

Impact of Active Antihyperglycemic Components as herbal therapy for Preventive Health Care Management of Diabetes.

Curr Mol Med 2019 Feb 19. Epub 2019 Feb 19.

Department of Bioscience and Biotechnology, Banasthali Vidyapith, Rajasthan. India.

Diabetes is a metabolic hyperglycemic condition that progressively develops, effect small and large sensory fibers in affected population. It has various complications as hypertension, coronary artery disease, stroke, blindness, kidney disease as well as peripheral neuropathy. Sulfonylureas, thiazolidinediones, metformin, biguanidine, acarbose and insulin are commonly used drugs by diabetic patients, but these all have certain side effects. Read More

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http://dx.doi.org/10.2174/1566524019666190219124301DOI Listing
February 2019
6 Reads

Randomized Controlled Trial of Physical Exercise in Diabetic Veterans With Length-Dependent Distal Symmetric Polyneuropathy.

Front Neurosci 2019 11;13:51. Epub 2019 Feb 11.

Research Service, Department of Veterans Affairs, Edward Hines Jr. VA Hospital, Hines, IL, United States.

Physical exercise is an essential adjunct to the management of patients with type 2 diabetes mellitus. Therapeutic interventions that improve blood flow to peripheral nerves, such as exercise, may slow the progression of neuropathy in the diabetic patient. This randomized clinical trial was conducted to determine whether a structured program of aerobic, isokinetic strength, or the combination of aerobic-isokinetic strength exercise intervention alters peripheral nerve function in glycemic-controlled diabetic patients with advanced length-dependent distal symmetric polyneuropathy. Read More

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http://dx.doi.org/10.3389/fnins.2019.00051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379046PMC
February 2019
2 Reads

An update on the genetics, clinical presentation, and pathomechanisms of human riboflavin transporter deficiency.

J Inherit Metab Dis 2019 Jan 12. Epub 2019 Jan 12.

MRC Centre for Neuromuscular Diseases, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK.

Riboflavin transporter deficiency (RTD) is a rare neurological condition that encompasses the Brown-Vialetto-Van Laere and Fazio-Londe syndromes since the discovery of pathogenic mutations in the SLC52A2 and SLC52A3 genes that encode human riboflavin transporters RFVT2 and RFVT3. Patients present with a deteriorating progression of peripheral and cranial neuropathy that causes muscle weakness, vision loss, deafness, sensory ataxia, and respiratory compromise which when left untreated can be fatal. Considerable progress in the clinical and genetic diagnosis of RTDs has been made in recent years and has permitted the successful lifesaving treatment of many patients with high dose riboflavin supplementation. Read More

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http://dx.doi.org/10.1002/jimd.12053DOI Listing
January 2019
1 Read

Randomised controlled trial of the impact of haemodiafiltration on uraemic neuropathy: FINESSE study protocol.

BMJ Open 2019 Jan 15;9(1):e023736. Epub 2019 Jan 15.

Renal and Metabolic, The George Institute for Global Health, UNSW, Newtown, New South Wales, Australia.

Introduction: The majority of patients undergoing haemodialysis (HD) show evidence of uraemic neuropathy, a condition with no known disease-modifying treatments. The pathogenesis of uraemic neuropathy is poorly understood, but may be related to cumulative exposure to middle molecules or other solutes such as potassium. It is not known whether haemodiafiltration (HDF) reduces the progression of uraemic neuropathy. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340424PMC
January 2019
4 Reads

Intestinal nerve cell injury occurs prior to insulin resistance in female mice ingesting a high-fat diet.

Cell Tissue Res 2019 Feb 18. Epub 2019 Feb 18.

Department of Biological Sciences, University of Idaho, 875 Perimeter Drive, LSS 252, Moscow, ID, 83844, USA.

Diabetic patients suffer from gastrointestinal disorders associated with dysmotility, enteric neuropathy and dysbiosis of gut microbiota; however, gender differences are not fully known. Previous studies have shown that a high-fat diet (HFD) causes type two diabetes (T2D) in male mice after 4-8 weeks but only does so in female mice after 16 weeks. This study seeks to determine whether sex influences the development of intestinal dysmotility, enteric neuropathy and dysbiosis in mice fed HFD. Read More

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http://dx.doi.org/10.1007/s00441-019-03002-0DOI Listing
February 2019
2 Reads

Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease.

Front Cell Neurosci 2019 29;13. Epub 2019 Jan 29.

Departamento de Neurología, Escuela de Medicina and Centro Interdisciplinario de Neurociencias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Oligodendrocytes are the myelin forming cells in the central nervous system (CNS). In addition to this main physiological function, these cells play key roles by providing energy substrates to neurons as well as information required to sustain proper synaptic transmission and plasticity at the CNS. The latter requires a fine coordinated intercellular communication with neurons and other glial cell types, including astrocytes. Read More

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http://dx.doi.org/10.3389/fncel.2019.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361860PMC
January 2019

The Importance of Peripheral Nerves in Adipose Tissue for the Regulation of Energy Balance.

Biology (Basel) 2019 Feb 12;8(1). Epub 2019 Feb 12.

Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME 04469, USA.

Brown and white adipose tissues are essential for maintenance of proper energy balance and metabolic health. In order to function efficiently, these tissues require both endocrine and neural communication with the brain. Brown adipose tissue (BAT), as well as the inducible brown adipocytes that appear in white adipose tissue (WAT) after simulation, are thermogenic and energy expending. Read More

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http://dx.doi.org/10.3390/biology8010010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466238PMC
February 2019

Small heat shock proteins: multifaceted proteins with important implications for life.

Cell Stress Chaperones 2019 Mar 13;24(2):295-308. Epub 2019 Feb 13.

Laboratory of Cell and Developmental Genetics, IBIS, and Department of Molecular Biology, Medical Biochemistry and Pathology, Medical School, Université Laval, QC, Québec, G1V 0A6, Canada.

Small Heat Shock Proteins (sHSPs) evolved early in the history of life; they are present in archaea, bacteria, and eukaryota. sHSPs belong to the superfamily of molecular chaperones: they are components of the cellular protein quality control machinery and are thought to act as the first line of defense against conditions that endanger the cellular proteome. In plants, sHSPs protect cells against abiotic stresses, providing innovative targets for sustainable agricultural production. Read More

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http://dx.doi.org/10.1007/s12192-019-00979-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439001PMC
March 2019
7 Reads

Neurologic Conditions: Common Peripheral Neuropathies.

FP Essent 2019 Feb;477:11-15

University of South Alabama College of Medicine Department of Family Medicine, 1601 Center Street, 2N Mobile, AL 36604.

Peripheral neuropathies (PNs) are a group of conditions caused by damage to the peripheral nervous system. PN is a condition commonly seen in the family medicine setting and can lead to reduced quality of life due to pain, ulceration, and falls. More than 100 etiologies of PN have been identified; the most common are metabolic, drug-related, and systemic etiologies. Read More

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February 2019
2 Reads

The Effect of Sodium Channel Blocker, Mexiletine, on Body Weight in Type 2 Diabetes Patients with Visceral Obesity.

Authors:
Naohiko Ueno

Clin Med Insights Endocrinol Diabetes 2019 22;12:1179551418825049. Epub 2019 Jan 22.

Ueno Internal Medicine and Diabetes Clinic, Kobe, Japan.

Objective: Mexiletine is an anti-arrhythmic agent also used for the treatment of painful diabetic neuropathy. In this study, the effect of mexiletine on body weight was evaluated in type 2 diabetes patients with diabetic neuropathy exhibiting visceral obesity.

Methods: Type 2 diabetes patients with neuropathy exhibiting visceral obesity (n = 21) treated by mexiletine (300 mg/day) and a control group of type 2 diabetes patients with the same condition who received vitamin B (n = 12) were retrospectively evaluated. Read More

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http://dx.doi.org/10.1177/1179551418825049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343451PMC
January 2019
1 Read

Integrative metabolomics reveals unique metabolic traits in Guillain-Barré Syndrome and its variants.

Sci Rep 2019 Jan 31;9(1):1077. Epub 2019 Jan 31.

The Department of Bio and Fermentation Convergence Technology, BK21 PLUS Program, Kookmin University, Seoul, 02707, Republic of Korea.

Guillain-Barré syndrome (GBS) is an acute fatal progressive disease caused by autoimmune mechanism mainly affecting peripheral nervous system. Although the syndrome is clinically sub-classified into several variants, specific biomarker and exact pathomechanism of each subtypes are not well elucidated yet. In current study, integrative metabolomic and lipidomic profiles were acquisitioned from cerebrospinal fluid samples of 86 GBS from three variants and 20 disease controls. Read More

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http://dx.doi.org/10.1038/s41598-018-37572-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355784PMC
January 2019
3 Reads

Mitochondrial uncoupling has no effect on microvascular complications in type 2 diabetes.

Sci Rep 2019 Jan 29;9(1):881. Epub 2019 Jan 29.

Department of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA.

Diabetic peripheral neuropathy (DPN), diabetic kidney disease (DKD), and diabetic retinopathy (DR) contribute to significant morbidity and mortality in diabetes patients. The incidence of these complications is increasing with the diabetes epidemic, and current therapies minimally impact their pathogenesis in type 2 diabetes (T2D). Improved mechanistic understanding of each of the diabetic complications is needed in order to develop disease-modifying treatments for patients. Read More

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http://www.nature.com/articles/s41598-018-37376-y
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http://dx.doi.org/10.1038/s41598-018-37376-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351661PMC
January 2019
3 Reads

Late-onset and fast progressive neuropathy and cardiomyopathy in Val32Ala transthyretin gene mutation.

Neurol Sci 2019 Jan 26. Epub 2019 Jan 26.

Neuroalgology Unit, Department of Clinical Neurosciences, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Via Celoria, 11, 20133, Milan, Italy.

More than 100 mutations of the transthyretin gene have been reported in autosomal dominant familial amyloid polyneuropathy. This rare disease causes severe motor and sensory disability, dysautonomia, and in some patients also cardiomyopathy. The diagnosis can be challenging mainly in sporadic adult patients showing clinical, laboratory, and neurophysiological findings overlapping other forms of chronic neuropathy. Read More

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http://dx.doi.org/10.1007/s10072-019-3716-zDOI Listing
January 2019

HADHA and HADHB gene associated phenotypes - Identification of rare variants in a patient cohort by Next Generation Sequencing.

Mol Cell Probes 2019 04 22;44:14-20. Epub 2019 Jan 22.

Medical Genetics Center, Munich, Germany; Department of Neurology, Friedrich-Baur-Institute, Klinikum der Ludwig-Maximilians-University, Munich, Germany. Electronic address:

The heterooctameric mitochondrial trifunctional protein (MTP), composed of four α- and β-subunits harbours three enzymes that each perform a different function in mitochondrial fatty acid β-oxidation. Pathogenic variants in the MTP genes (HADHA and HADHB) cause MTP deficiency, a rare autosomal recessive metabolic disorder characterized by phenotypic heterogeneity ranging from severe, early-onset, cardiac disease to milder, later-onset, myopathy and neuropathy. Since metabolic myopathies and neuropathies are a group of rare genetic disorders and their associated muscle symptoms may be subtle, the diagnosis is often delayed. Read More

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http://dx.doi.org/10.1016/j.mcp.2019.01.003DOI Listing
April 2019
1 Read

Tannins and vascular complications of Diabetes: An update.

Phytomedicine 2019 Mar 22;56:229-245. Epub 2018 Oct 22.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400 056, India. Electronic address:

Background: Diabetes mellitus is a chronic metabolic disorder associated with persistent increased level of glucose in the blood. According to a report by World Health Organisation (WHO), prevalence of diabetes among adults over 18 years of age had reached to 8.5% in year 2014 which was 4. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.10.026DOI Listing
March 2019
5 Reads

Methylglyoxal, a potent inducer of AGEs, connects between diabetes and cancer.

Diabetes Res Clin Pract 2019 Feb 18;148:200-211. Epub 2019 Jan 18.

Metastasis Research Laboratory, GIGA-Cancer, University of Liège, Belgium. Electronic address:

Diabetes is one of the most frequent diseases throughout the world and its incidence is predicted to exponentially progress in the future. This metabolic disorder is associated with major complications such as neuropathy, retinopathy, atherosclerosis, and diabetic nephropathy, the severity of which correlates with hyperglycemia, suggesting that they are triggered by high glucose condition. Reducing sugars and reactive carbonyl species such as methylglyoxal (MGO) lead to glycation of proteins, lipids and DNA and the gradual accumulation of advanced glycation end products (AGEs) in cells and tissues. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.002DOI Listing
February 2019
21 Reads
2.538 Impact Factor

The diabetes pandemic and associated infections: suggestions for clinical microbiology.

Rev Med Microbiol 2019 Jan 1;30(1):1-17. Epub 2018 Nov 1.

Institute of Clinical Physiology, CNR, Pisa, Italy.

There are 425 million people with diabetes mellitus in the world. By 2045, this figure will grow to over 600 million. Diabetes mellitus is classified among noncommunicable diseases. Read More

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http://dx.doi.org/10.1097/MRM.0000000000000155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319590PMC
January 2019
24 Reads

The 2017 Banting Memorial Lecture The diabetic lower limb - a forty year journey: from clinical observation to clinical science.

Diabet Med 2019 Jan 19. Epub 2019 Jan 19.

Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, University of Manchester, Manchester, UK.

A series of clinical research projects conducted over the past 40 years, all of which were informed by clinical observation or discussions with people with diabetes and staff colleagues are described in this review. A study of necrobiosis lipoidica diabeticorum confirmed that this rare skin complication occurs predominantly in young women with Type 1 diabetes and other microvascular complications. Biopsies of necrobiotic lesions showed destruction of superficial nerve fibres by inflammatory tissue, which likely causes the sensory loss in lesions that is pathognomonic of the condition. Read More

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http://dx.doi.org/10.1111/dme.13901DOI Listing
January 2019
4 Reads

High rates of atherogenic dyslipidemia, β-cell function loss, and microangiopathy among Turkish migrants with T2DM.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):716-720. Epub 2018 Nov 24.

Division of Cardiology, Cliniques universitaires St-Luc and Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Brussels, Belgium.

Aims: Non-Caucasian migrants require dedicated approaches in diabetes management due to specific genetic; socio-cultural; demographic and anthropological determinants. Documenting such phenotypes allows for better understanding unmet needs and management priorities.

Methods: This age- and sex-adjusted case-control (1:6 ratio) study compared 56 T2DM Turkish migrants (70% males) resident in Belgium [Tu] with 336 T2DM Caucasians [Ca], all benefiting from state-funded healthcare. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18714021183056
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http://dx.doi.org/10.1016/j.dsx.2018.11.049DOI Listing
November 2018
8 Reads

Ethnicity and diabetes complications in Sudanese population: The need for further genetic population testing.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):430-433. Epub 2018 Oct 11.

Department of Pathology, Faculty of Medicine, University of Medical Sciences and Technology, Khartoum, Sudan.

Background: The aim of the present study was to assess whether there is an association between ethnicity and the high prevalence of diabetes complications in Sudan.

Methods: This was cross-sectional hospital-based study with 316 individuals with diabetes conducted in Khartoum state, Sudan. A questionnaire was used to collect demographic information. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.10.017DOI Listing
October 2018
2 Reads