Thromb Res 2013 Aug 16;132(2):170-4. Epub 2013 Jul 16.
Department of Pediatrics and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado and Children's Hospital Colorado, Aurora, CO, USA; Department of Medicine and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado and Children's Hospital Colorado, Aurora, CO, USA.
Objective: Elevated plasma homocysteine (tHcy) and the MTHFR c.677C>T variant have been postulated to increase the risk of venous thromboembolism (VTE), although mechanisms and implications to pediatrics remain incompletely understood. The objectives of this study were to determine the prevalences of elevated tHcy and MTHFR variant in a pediatric population with VTE or arterial ischemic stroke (AIS), and to determine associations with thrombus outcomes. Read More