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Thromb Res 2013 Aug 16;132(2):170-4. Epub 2013 Jul 16.

Department of Pediatrics and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado and Children's Hospital Colorado, Aurora, CO, USA; Department of Medicine and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado and Children's Hospital Colorado, Aurora, CO, USA.

Objective: Elevated plasma homocysteine (tHcy) and the MTHFR c.677C>T variant have been postulated to increase the risk of venous thromboembolism (VTE), although mechanisms and implications to pediatrics remain incompletely understood. The objectives of this study were to determine the prevalences of elevated tHcy and MTHFR variant in a pediatric population with VTE or arterial ischemic stroke (AIS), and to determine associations with thrombus outcomes. Read More

J Neurol Sci 2007 Sep 3;260(1-2):298-9. Epub 2007 May 3.

No To Shinkei 2004 Sep;56(9):781-4

Department of Neurosurgery, Aomori Prefectural Central Hospital, Japan.

Homocystinuria is a congenital metabolic disorder, and has been known as life-threatening risk factor of vascular disease including ischemic stroke. We report a case of cerebral infarction due to homocystinuria. The patient was a 21-year-old woman exhibiting left hemiparesis and a previous history of ectopia lentis. Read More

J Insur Med 1998 ;30(4):231-6

Lincoln National Re, Fort Wayne, IN 46804, USA.

Objective: To determine the importance of homocysteinemia as a risk factor for atherosclerotic vascular disease.

Design: Literature review of published studies homocysteine as risk factor for atherosclerotic vascular disease.

Methods: MEDLINE search from 1969 to 1998 using homocysteine and vascular disease as search terms, from which 13 articles were selected for review. Read More

Stroke 1984 Nov-Dec;15(6):1012-6

Highly elevated concentrations of homocysteine measured as homocysteine or cysteine-homocysteine mixed disulfide (MDS) are found in plasma and urine in subjects with inherited abnormalities of the methionine metabolism. These subjects have a high incidence of arteriosclerotic vascular complications during childhood. Homocysteine causes endothelial cell injury and cell detachment that initiates the development of arteriosclerosis. Read More