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    3229 results match your criteria Metabolic Alkalosis

    1 OF 65

    Acid-base status and its clinical implications in critically ill patients with cirrhosis, acute-on-chronic liver failure and without liver disease.
    Ann Intensive Care 2018 Apr 19;8(1):48. Epub 2018 Apr 19.
    Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
    Background: Acid-base disturbances are frequently observed in critically ill patients at the intensive care unit. To our knowledge, the acid-base profile of patients with acute-on-chronic liver failure (ACLF) has not been evaluated and compared to critically ill patients without acute or chronic liver disease.

    Results: One hundred and seventy-eight critically ill patients with liver cirrhosis were compared to 178 matched controls in this post hoc analysis of prospectively collected data. Read More

    Accuracy of Acid-Base Diagnoses Using the Central Venous Blood Gas in the Medical Intensive Care Unit.
    Nephron 2018 Apr 12. Epub 2018 Apr 12.
    Renal, Electrolyte and Hypertension Division of the Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
    Background: Acid-base disturbances are frequent in critically ill patients. Arterial blood gas (ABG) is the gold standard in the diagnosis of these disturbances, but it is invasive with potential hazards. For patients with a central venous catheter, venous blood gas (VBG) sampling may be an alternative, less-invasive diagnostic tool. Read More

    Evaluating off-label uses of acetazolamide.
    Am J Health Syst Pharm 2018 Apr;75(8):524-531
    Department of Pharmacy, Wexner Medical Center, Ohio State University, Columbus, OH.
    Purpose: Current off-label uses of acetazolamide in hospitalized patients are reviewed.

    Summary: Acetazolamide is a carbonic anhydrase inhibitor typically used for indications including epilepsy, glaucoma, edema, and altitude sickness but it may be prescribed in hospitalized patients for off-label indications. It inhibits carbonic anhydrase, which leads to reduced hydrogen ion secretion in the proximal renal tubule, resulting in increased bicarbonate and cation excretion and causing urinary alkalization and diuresis. Read More

    Clinical Complications of Continuous Renal Replacement Therapy.
    Contrib Nephrol 2018 29;194:109-117. Epub 2018 Mar 29.
    The various complications of continuous renal replacement therapy (CRRT) are mostly preventable. Hemodynamic disturbances are dominated by hypotension due to the modification of volume status, myocardial dysfunction, cardiac arrhythmia, or modification of systemic vascular resistances, which are correlated with body temperature changes. Metabolic complications remain at the forefront and have profoundly changed with the use of regional citrate anticoagulation (RCA). Read More

    Furosemide-induced tubular dysfunction responding to prostaglandin synthesis inhibitor therapy in a child with nephrotic syndrome.
    CEN Case Rep 2018 Mar 22. Epub 2018 Mar 22.
    Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
    Furosemide is one of the most common drug used to treat anasarca in childhood nephrotic syndrome. It has minimal side effects on short-term usage, but prolonged use can result in polyuria, hypokalemia and metabolic alkalosis. This pseudo-bartter complication can be treated by discontinuation of the drug with adequate potassium replacement. Read More

    Sporadic hypothyroidism-related hypokalemic paralysis: Diagnosis in a resource-poor setting.
    J Family Med Prim Care 2017 Oct-Dec;6(4):862-864
    Department of Neurology, JIPMER, Puducherry, India.
    Hypothyroidism and distal renal tubular acidosis causing hypokalemic paralysis (HP) have been described only in four female patients. HP as the initial manifestation of uncomplicated diabetes has been reported only in three young males. We report two middle-aged patients presenting with gradual-onset areflexic quadriparesis and neck flop, associated with urinary potassium losses, and recovering over 3 days. Read More

    An unusual manifestation of olfactory neuroblastoma.
    BMJ Case Rep 2018 Mar 13;2018. Epub 2018 Mar 13.
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, Washington, USA.
    A 62-year-old woman presented with an 11-month history of worsening nasal symptoms of rhinorrhoea, anosmia, nasal congestion and intermittent epistaxis. MRI revealed a large mass in the upper nasal vault. Biopsy of the mass revealed an olfactory neuroblastoma. Read More

    Liddle Syndrome: Review of the Literature and Description of a New Case.
    Int J Mol Sci 2018 Mar 11;19(3). Epub 2018 Mar 11.
    Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Torino, Via Genova 3, 10126 Torino, Italy.
    Liddle syndrome is an inherited form of low-renin hypertension, transmitted with an autosomal dominant pattern. The molecular basis of Liddle syndrome resides in germline mutations of the , and genes, encoding the α, β, and γ-subunits of the epithelial Na⁺ channel (ENaC), respectively. To date, 31 different causative mutations have been reported in 72 families from four continents. Read More

    Bartter Syndrome Type 1 Presenting as Nephrogenic Diabetes Insipidus.
    Case Rep Pediatr 2018 21;2018:9175271. Epub 2018 Feb 21.
    Medical Genetics Laboratory, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy.
    Bartter syndrome (BS) type 1 (OMIM #601678) is a hereditary salt-losing renal tubular disorder characterized by hypokalemic metabolic alkalosis, hypercalciuria, nephrocalcinosis, polyuria, recurrent vomiting, and growth retardation. It is caused by loss-of-function mutations of the gene, encoding the furosemide-sensitive Na-K-Cl cotransporter. Recently, a phenotypic variability has been observed in patients with genetically determined BS, including absence of nephrocalcinosis, hypokalemia, and/or metabolic alkalosis in the first year of life as well as persistent metabolic acidosis mimicking distal renal tubular acidosis. Read More

    Vitamin C Pharmacokinetics in Critically Ill Patients: A Randomized Trial of Four IV Regimens.
    Chest 2018 Mar 6. Epub 2018 Mar 6.
    Department of Intensive Care, VU University Medical Center, Amsterdam.
    Background: Early high-dose IV vitamin C is being investigated as adjuvant therapy in patients who are critically ill, but the optimal dose and infusion method are unclear. The primary aim of this study was to describe the dose-plasma concentration relationship and safety of four different dosing regimens.

    Methods: This was a four-group randomized pharmacokinetic trial. Read More

    A Young Patient with Leg Weakness and Hypokalemia-Case Report.
    Rambam Maimonides Med J 2018 Apr 19;9(2). Epub 2018 Apr 19.
    Department of Internal Medicine B, Rambam Health Care Campus, Haifa, Israel.
    A 20-year-old female patient was admitted to hospital because of bilateral leg weakness. Laboratory investigation showed metabolic alkalosis and severe hypokalemia. Differential diagnosis included mineralocorticoid or apparent mineralocorticoid excess diseases, with a high aldosterone-to-renin ratio (ARR) after correcting hypokalemia. Read More

    Acid-base assessment of patients receiving hemodialysis. What are our management goals?
    Semin Dial 2018 Mar 1. Epub 2018 Mar 1.
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
    Acid-base assessment of patients receiving conventional hemodialysis (HD) has been based solely on predialysis serum [total CO ], and treatment is currently driven by the KDOQI guideline from 2000. This guideline was directed solely at minimizing metabolic acidosis and thereby improving bone and muscle metabolism. In 2000, no data were available to assess the effects of acid-base status on morbidity and mortality. Read More

    Downregulation of the Cl-/HCO3-Exchanger Pendrin in Kidneys of Mice with Cystic Fibrosis: Role in the Pathogenesis of Metabolic Alkalosis.
    Cell Physiol Biochem 2018 21;45(4):1551-1565. Epub 2018 Feb 21.
    Background/aims: Patients with cystic fibrosis (CF) are prone to the development of metabolic alkalosis; however, the pathogenesis of this life threatening derangement remains unknown. We hypothesized that altered acid base transport machinery in the kidney collecting duct underlies the mechanism of impaired bicarbonate elimination in the CF kidney.

    Methods: Balance studies in metabolic cages were performed in WT and CFTR knockout (CF) mice with the intestinal rescue in response to bicarbonate loading or salt restriction, and the expression levels and cellular distribution of acid base and electrolyte transporters in the proximal tubule, collecting duct and small intestine were examined by western blots, northern blots and/or immunofluorescence labeling. Read More

    Acid-Base and Electrolyte Managements in Chronic Kidney Disease and End-Stage Renal Disease: Case-Based Discussion.
    Blood Purif 2018 26;45(1-3):179-186. Epub 2018 Jan 26.
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, College of Medicine, Rochester, Minnesota, USA.
    Acid-base and electrolyte alterations are common in patients with chronic kidney disease (CKD) and end-stage kidney failure (ESRD). The alterations become more complex as CKD advances to ESRD, leading to morbidity and mortality. Three cases are presented illustrating some key prototypic features in CKD and ESRD. Read More

    [Hypercalcaemia due to the milk-alkali syndrome].
    Ugeskr Laeger 2018 Feb;180(7)
    This case report is about an 87-year-old woman with Alzheimer's disease and the milk-alkali syndrome, who took calcium carbonate as osteoporosis prophylaxis. We describe, how the milk-alkali syndrome can result in a triad of hypercalcaemia, metabolic alkalosis, and renal insufficiency. The syndrome is now the third most common cause of hypercalcaemia because of the use of calcium carbonate in osteoporosis prophylaxis and treatment, and the syndrome should be considered in patients with hypercalcaemia, as it may result in permanent renal impairment. Read More

    Consequences of SPAK inactivation on Hyperkalemic Hypertension caused by WNK1 mutations: evidence for differential roles of WNK1 and WNK4.
    Sci Rep 2018 Feb 19;8(1):3249. Epub 2018 Feb 19.
    Institut National de la Santé et de la Recherche Médicale (INSERM), Unit 970, Paris Cardiovascular Research Center, Paris, France.
    Mutations of the gene encoding WNK1 [With No lysine (K) kinase 1] or WNK4 cause Familial Hyperkalemic Hypertension (FHHt). Previous studies have shown that the activation of SPAK (Ste20-related Proline/Alanine-rich Kinase) plays a dominant role in the development of FHHt caused by WNK4 mutations. The implication of SPAK in FHHt caused by WNK1 mutation has never been investigated. Read More

    Novel Compound Heterozygous CLCNKB Gene Mutations (c.1755A>G/ c.848_850delTCT) Cause Classic Bartter Syndrome.
    Am J Physiol Renal Physiol 2018 Feb 14. Epub 2018 Feb 14.
    Nephrology, Children's Hospital of Nanjing Medical University, China.
    Inactivated variants in CLCNKB gene encoding the basolateral chloride channel ClC-Kb cause classic Bartter syndrome characterized by hypokalemic metabolic alkalosis and hyperreninemic hyperaldosteronism. Here we identified two cBS siblings presenting hypokalemia in a Chinese family due to novel compound heterozygous CLCNKB mutations (c.848_850delTCT/c. Read More

    MILK-ALKALI SYNDROME (MAS) as a complication of the treatment of hypoparathyroidism.
    Endokrynol Pol 2018 Feb 14. Epub 2018 Feb 14.
    Warsaw University of Medicine.
    Milk-alkali syndrome (MAS), characterized by renal failure, metabolic alkalosis and hypercalcemia, is a severe and life-threatening complication of the treatment of hypoparathyroidism. The clinical course is often sudden and is not preceded by any prodromal symptoms. Occurrence does not depend on the duration of hypoparathyroidism treatment, although it is closely related to the applied therapy, especially the dose of calcium carbonate and active vitamin D preparations. Read More

    Nephropathic Cystinosis Mimicking Bartter Syndrome: a Novel Mutation.
    Iran J Kidney Dis 2018 01;12(1):61-63
    Kayseri Education and Research Hospital, Department of Pediatric Nephrology, Kayseri, Turkey.
    Cystinosis is a rare autosomal recessive disorder resulting from defective lysosomal transport of cystine due to mutations in the cystinosin lysosomal cystine transporter (CTNS) gene. The clinical phenotype of nephropathic cystinosis is characterized by renal tubular Fanconi syndrome and development of end-stage renal disease during the first decade. Although metabolic acidosis is the classically prominent finding of the disease, a few cases may present with hypokalemic metabolic alkalosis mimicking Bartter syndrome. Read More

    Medical findings in 1,026 consecutive adult inpatient-residential eating disordered patients.
    Int J Eat Disord 2018 Apr 8;51(4):305-313. Epub 2018 Feb 8.
    Eating Recovery Center, Denver, Denver, Colorado.
    Objective: Eating disorders are associated with multiple medical complications. We report contemporary medical data, for newly admitted adult inpatient and residential level of care patients.

    Method: Medical records of a transdiagnostic sample of 1,026 patients, with eating disorders, were retrospectively reviewed for the presence of a broad array of medical complications at time of admission. Read More

    Two mutations in the thiazide-sensitive NaCl co-transporter gene in a Romanian Gitelman syndrome patient: case report.
    Ther Clin Risk Manag 2018 22;14:149-155. Epub 2018 Jan 22.
    Department of Functional Sciences.
    Background: Gitelman syndrome (GS) is considered as the most common renal tubular disorder, and we report the first Romanian patient with GS confirmed at molecular level and diagnosed according to genetic testing.

    Patient And Methods: This paper describes the case of a 27-year-old woman admitted with severe hypokalemia, slight hypomagnesemia, hypocalcemia, hypocalciuria, metabolic alkalosis, hyperreninemia, low blood pressure, limb muscle weakness, marked fatigue and palpitations. Family history revealed a consanguineous family with autosomal-recessive transmission of GS with two cases over five generations. Read More

    Itraconazole induced hypertension and hypokalemia: Mechanistic evaluation.
    Mycoses 2018 May 15;61(5):337-339. Epub 2018 Feb 15.
    Department of Medical Microbiology and Immunology, University of California-Davis, Davis, CA, USA.
    We describe a case of apparent mineralocorticoid excess (hypertension, hypokalemia, metabolic alkalosis and low plasma renin activity) secondary to itraconazole therapy. Inhibition of 11β-hydroxysteroid dehydrogenase 2 was demonstrated, and withholding itraconazole led to resolution of adverse effects that did not recur with voriconazole. This report adds to a growing body of evidence linking apparent mineralocorticoid excess with certain triazoles. Read More

    A novel compound heterozygous variant of the SLC12A3 gene in Gitelman syndrome pedigree.
    BMC Med Genet 2018 Jan 29;19(1):17. Epub 2018 Jan 29.
    Department of Endocrinology, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, 3 East Qing Chun Road, Zhejiang, Hangzhou, 310016, China.
    Background: Gitelman syndrome (GS) is an autosomal recessive disorder caused by genic mutations of SLC12A3 (Solute carrier family 12 member 3), which encodes the Na-Cl cotransporter (NCC), and presents with characteristic metabolic abnormalities, including hypokalemia, metabolic alkalosis, hypomagnesemia, and hypocalciuria. In this study, we report a case of a GS pedigree, including analysis of GS-associated gene mutations.

    Methods: We performed next-generation sequencing analysis and Sanger sequencing to explore the SLC12A3 mutations in a GS pedigree that included a 35-year-old female patient with GS and five family members within three generations. Read More

    Coexistence of Gitelman Syndrome and Hypertrophic Cardiomyopathy in a Pregnant Woman.
    Acta Cardiol Sin 2018 Jan;34(1):92-95
    Faculty of Medicine, Department of Cardiology, Yıldırım Beyazıt University, Ankara, Turkey.
    Gitelman syndrome (GS) is transmitted as an autosomal recessive trait and characterized by hypokalemic metabolic alkalosis in combination with significant hypomagnesemia and low urinary calcium excretion. The symptoms and severity of the disease can vary greatly from one person to another and can range from mild to severe. Sudden cardiac arrest has been reported occasionally as well. Read More

    Retrospective Review of Hydrochloric Acid Infusion for the Treatment of Metabolic Alkalosis in Surgical Intensive Care Unit Patients.
    Ann Pharmacother 2018 Jan 1:1060028018754389. Epub 2018 Jan 1.
    2 University of Rochester Medical Center, Rochester, NY, USA.
    Background: Older reports of use of hydrochloric acid (HCl) infusions for treatment of metabolic alkalosis document variable dosing strategies and risk.

    Objectives: This study sought to characterize use of HCl infusions in surgical intensive care unit patients for the treatment of metabolic alkalosis.

    Methods: This retrospective review included patients who received a HCl infusion for >8 hours. Read More

    Acquired pyloric stenosis resulting in hypokalaemic, hyperchloraemic normal anion gap metabolic acidosis. Persistent vomiting in an adult: cause and effect.
    BMJ Case Rep 2018 Jan 17;2018. Epub 2018 Jan 17.
    Department of Emergency, Royal United Hospital, Bath, UK.
    A 24-year-old woman presented with a history of persistent vomiting for at least 3 months. This resulted in severe dehydration with risk of acute kidney injury. In addition to volume depletion, loss of gastric fluid resulted in a specific metabolic derangement-hypokalaemic, hypochloraemic normal anion gap metabolic alkalosis with a reduced ionised calcium concentration and paradoxical aciduria. Read More

    Acid-Base and Electrolyte Disorders in Patients with and without Chronic Kidney Disease: An Update.
    Kidney Dis (Basel) 2017 Dec 5;3(4):136-148. Epub 2017 Oct 5.
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
    Kidneys play a pivotal role in the maintenance and regulation of acid-base and electrolyte homeostasis, which is the prerequisite for numerous metabolic processes and organ functions in the human body. Chronic kidney diseases compromise the regulatory functions, resulting in alterations in electrolyte and acid-base balance that can be life-threatening. In this review, we discuss the renal regulations of electrolyte and acid-base balance and several common disorders including metabolic acidosis, alkalosis, dysnatremia, dyskalemia, and dysmagnesemia. Read More

    Potassium intake modulates the thiazide-sensitive sodium-chloride cotransporter (NCC) activity via the Kir4.1 potassium channel.
    Kidney Int 2018 Apr 6;93(4):893-902. Epub 2018 Jan 6.
    Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA. Electronic address:
    Kir4.1 in the distal convoluted tubule plays a key role in sensing plasma potassium and in modulating the thiazide-sensitive sodium-chloride cotransporter (NCC). Here we tested whether dietary potassium intake modulates Kir4. Read More

    The effect of metabolic alkalosis on the ventilatory response in healthy subjects.
    Respir Physiol Neurobiol 2018 Feb 4;249:47-53. Epub 2018 Jan 4.
    Department of Critical Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Intensive Care Medicine, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:
    Background: Patients with acute respiratory failure may develop respiratory acidosis. Metabolic compensation by bicarbonate production or retention results in posthypercapnic alkalosis with an increased arterial bicarbonate concentration. The hypothesis of this study was that elevated plasma bicarbonate levels decrease respiratory drive and minute ventilation. Read More

    S737F is a new CFTR mutation typical of patients originally from the Tuscany region in Italy.
    Ital J Pediatr 2018 Jan 3;44(1). Epub 2018 Jan 3.
    Centro Regionale Toscano per la Fibrosi Cistica, Azienda Ospedaliero-Universitaria Meyer, Via Gaetano Pieraccini 24, 50141, Florence, Italy.
    Background: An increasing number of patients have been described as having a number of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) variants for which it lacks a clear genotype-phenotype correlation. We assesses the clinical features of patients bearing the S737F (p.Ser737Phe) CFTR missense variant and evaluated the residual function of CFTR protein on nasal epithelial cells (NEC). Read More

    Significance of clinical observations and biochemical alterations in buffalo calves with dietary abomasal impaction.
    BMC Vet Res 2018 Jan 2;14(1). Epub 2018 Jan 2.
    Department of Animal Husbandry and Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.
    Background: The present study aimed to throw light on the clinical characteristics of abomasal impaction in buffalo calves and its associated biochemical alterations. For this reason, a total of 20 male buffalo calves (Bubalus bubalis) with abomasal impaction were studied. The investigated calves were at 6 to 12 months of age and were belonged to three private farms in Dakahlia Governorate besides sporadic cases admitted to the Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Mansoura University, Egypt. Read More

    Renal intercalated cells and blood pressure regulation.
    Kidney Res Clin Pract 2017 Dec 31;36(4):305-317. Epub 2017 Dec 31.
    Departments of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
    Type B and non-A, non-B intercalated cells are found within the connecting tubule and the cortical collecting duct. Of these cell types, type B intercalated cells are known to mediate Cl absorption and HCO secretion largely through pendrin-dependent Cl/HCO exchange. This exchange is stimulated by angiotensin II administration and is also stimulated in models of metabolic alkalosis, for instance after aldosterone or NaHCO administration. Read More

    Clinical, genetic, and structural basis of apparent mineralocorticoid excess due to 11β-hydroxysteroid dehydrogenase type 2 deficiency.
    Proc Natl Acad Sci U S A 2017 Dec 11;114(52):E11248-E11256. Epub 2017 Dec 11.
    Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029;
    Mutations in 11β-hydroxysteroid dehydrogenase type 2 gene () cause an extraordinarily rare autosomal recessive disorder, apparent mineralocorticoid excess (AME). AME is a form of low renin hypertension that is potentially fatal if untreated. Mutations in the gene result either in severe AME or a milder phenotype (type 2 AME). Read More

    Oxidative stress in urea cycle disorders: Findings from clinical and basic research.
    Clin Chim Acta 2018 Feb 1;477:121-126. Epub 2017 Dec 1.
    Curso de Especialização em Análises Clínicas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre-RS, Brazil; Programa de Pós-Graduação em Ciências Biológicas - Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre-RS, Brazil; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre-RS, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre-RS, Brazil. Electronic address:
    Inborn errors of metabolism (IEM) comprise a group of over 600 disorders, each with a specific metabolic impairment due to a genetic defect. Urea cycle disorders (UCD) are IEM that affect the nitrogen disposal system, leading to hyperammonemia and the accumulation of other toxic metabolites in tissues of affected patients. UCD arise from mutations in the genes coding any of the enzymes participating in the urea cycle, either directly or as regulators of this pathway, causing severe respiratory alkalosis. Read More

    Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction.
    Crit Care 2017 Nov 29;21(1):294. Epub 2017 Nov 29.
    Department of Anaesthesiology, Intensive Care Medicine and Pain Medicine, Saarland University Medical Centre, Homburg/Saar, Germany.
    Background: As of 2009, anticoagulation with citrate was standard practice in continuous renal replacement therapy (CRRT) for critically ill patients at the University Medical Centre of Saarland, Germany. Partial hepatic metabolism of citrate means accumulation may occur during CRRT in critically ill patients with impaired liver function. The aim of this study was to evaluate the actual influence of hepatic function on citrate-associated complications during long-term CRRT. Read More

    Safety and efficacy of regional citrate anticoagulation in continuous blood purification treatment of patients with multiple organ dysfunction syndrome.
    Braz J Med Biol Res 2017 Nov 17;51(1):e6378. Epub 2017 Nov 17.
    Intensive Care Units, Branch of the First Affiliated Hospital of Xinjiang Medical University, Changji, Xinjiang, China.
    The aim of this study was to discuss the safety and efficacy of regional citrate anticoagulation (RCA) on continuous blood purification (CBP) during the treatment of multiple organ dysfunction syndrome (MODS). Thirty-five patients with MODS were divided into two groups: the local citrate anticoagulation (RCA) group, and the heparin-free blood purification (hfBP) group. The MODS severity was assessed according to Marshall's MODS score criteria. Read More

    Sodium bicarbonate improves 4 km time trial cycling performance when individualised to time to peak blood bicarbonate in trained male cyclists.
    J Sports Sci 2018 Aug 29;36(15):1705-1712. Epub 2017 Nov 29.
    a Sports Nutrition and Performance Group, Department of Sport and Physical Activity , Edge Hill University , Ormskirk , UK.
    The aim of this study was to investigate the effects of sodium bicarbonate (NaHCO) on 4 km cycling time trial (TT) performance when individualised to a predetermined time to peak blood bicarbonate (HCO). Eleven male trained cyclists volunteered for this study (height 1.82 ± 0. Read More

    Salicylate Intoxication in an Infant: A Case Report.
    Drug Saf Case Rep 2017 Nov 27;4(1):23. Epub 2017 Nov 27.
    Intensive Care Unit, Paediatric Department, Hospital of Santa Maria, Lisbon, Portugal.
    In children, the most common cause of an elevated anion gap (AG) with ketonemia, ketonuria, hyperglycemia, and glycosuria is diabetic ketoacidosis. However, when the clinical history is not clear, other causes must be considered. A 9-month-old girl was transferred to our pediatric intensive care unit (PICU) because of severe metabolic acidosis. Read More

    Complications of regional citrate anticoagulation: accumulation or overload?
    Crit Care 2017 Nov 19;21(1):281. Epub 2017 Nov 19.
    Anesthesiology and Intensive Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.
    Regional citrate anticoagulation (RCA) is now recommended over systemic heparin for continuous renal replacement therapy in patients without contraindications. Its use is likely to increase throughout the world. However, in the absence of citrate blood level monitoring, the diagnosis of citrate accumulation, the most feared complication of RCA, remains relatively complex. Read More

    Antenatal Bartter syndrome presenting with vomiting and constipation mimicking subacute intestinal obstruction in a 20-day-old neonate.
    BMJ Case Rep 2017 Nov 14;2017. Epub 2017 Nov 14.
    Hamad Medical Corporation, Doha, Qatar.
    Antenatal Bartter syndrome is a rare condition that can present with different clinical features. These features include early onset maternal polyhydramnios, failure to thrive, prematurity and nephrocalcinosis.We are presenting this 20-day-old girl who had an antenatal history of polyhydramnios. Read More

    The nutritional limitations of plant-based beverages in infancy and childhood.
    Nutr Hosp 2017 Oct 24;34(5):1205-1214. Epub 2017 Oct 24.
    Hospital La Fe.Valencia.
    Breastfeeding, infant formula and cow's milk are basic foods in infant nutrition. However, they are being increasingly replaced either totally or partially by plant-based beverages.The composition of 164 plant-based beverages available in Spain was reviewed based on the nutritional labeling of the package and the manufacturers' webpages. Read More

    Leigh syndrome in individuals bearing m.9185T>C MTATP6 variant. Is hyperventilation a factor which starts its development?
    Metab Brain Dis 2018 Feb 7;33(1):191-199. Epub 2017 Nov 7.
    Department of Medical Genetics, The Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730, Warsaw, Poland.
    Leigh syndrome (LS), subacute necrotizing encephalomyelopathy is caused by various genetic defects, including m.9185T>C MTATP6 variant. Mechanism of LS development remains unknown. Read More

    [A case of Gitelman syndrome with physical retardation].
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Oct;42(10):1236-1238
    Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, China.
    Gitelman syndrome is a rare disease. It is easy to be misdiagnosed and missed diagnosis due to the diverse clinical symptoms. A girl with long-term hypokalemia, who presented with intermittent pain of lower limb muscle and physical retardation, was treated in Xiangya Hospital, Central South University. Read More

    Primary Hyperaldosteronism Due to Adrenocortical Adenoma: a Case Report.
    Acta Med Indones 2017 Jul;49(3):249-254
    Department of Internal Medicine Faculty of Medicine, Diponegoro University - Dr. Kariadi Hospital Semarang, Indonesia.
    Primary hyperaldosteronism is an adrenal abnormality in which there is some degree of autonomy of aldosterone secretion. We report a case of thirty three years old Javanese female presented with uncontrolled hypertension, muscular weakness, cramps  and progressing shortness of breath during working for 6 years. She had history of hypertension since age 20. Read More

    A Basic Therapy Gone Awry.
    Am J Crit Care 2017 Nov;26(6):491-494
    Laura B. Galinko is an anesthesiology resident at New York Presbyterian Hospital/Weill Cornell Medical College, New York, New York. At the time of this case report, Steven H. Hsu was a critical care medicine fellow and Michael L. Fingerhood was a pulmonary medicine fellow at Memorial Sloan Kettering Cancer Center, New York, New York. Cosmin Gauran is an assistant attending, Stephen M. Pastores is the critical care fellowship director, and Neil A. Halpern is the director of the Critical Care Center, and Sanjay Chawla is an associate attending in the Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center.
    Baking soda (sodium bicarbonate) is a common household item that has gained popularity as an alternative cancer treatment. Some have speculated that alkali therapy neutralizes the extracellular acidity of tumor cells that promotes metastases. Internet blogs have touted alkali as a safe and natural alternative to chemotherapy that targets cancer cells without systemic effects. Read More

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