3,443 results match your criteria Metabolic Alkalosis


A 39 year-old woman with milk-alkali syndrome complicated by posterior reversible encephalopathy syndrome.

Bone Rep 2020 Jun 4;12:100278. Epub 2020 May 4.

Grand Strand Medical Center, 809 82nd Pkwy, Myrtle Beach, SC 29572, United States.

Milk-alkali syndrome (MAS) is characterized by the triad of hypercalcemia, metabolic alkalosis, and acute kidney injury. Once thought to be a rare condition, there has been a resurgence of cases due to the consumption of calcium-containing supplements for osteoporosis prevention and dyspepsia in the general population. We describe the case of a female who presented with acute encephalopathy, hypercalcemia, and new-onset seizure. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235952PMC

Diet-Exercise Induced Hypokalemic Metabolic Alkalosis.

Am J Med 2020 May 19. Epub 2020 May 19.

Divisions of Dietetics, Department of Internal Medicine, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.amjmed.2020.04.019DOI Listing

Intralipid and haemodialysis in caffeine overdose.

BMJ Case Rep 2020 May 14;13(5). Epub 2020 May 14.

Critical Care, Queen Elizabeth Woolwich, London, UK.

A 26-year-old woman presented after an intentional ingestion of 20 g of caffeine. She suffered a profound respiratory alkalosis with metabolic acidosis, hypokalaemia and sustained polymorphic ventricular tachycardia. She was treated with intravenous intralipid and haemodialysis, and her arrhythmia was controlled using magnesium sulphate. Read More

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http://dx.doi.org/10.1136/bcr-2020-234256DOI Listing

Milk-alkali syndrome: a 'quick ease' or a 'long-lasting problem'.

Endocrinol Diabetes Metab Case Rep 2020 May 13;2020. Epub 2020 May 13.

Department of Endocrinology, Nepean Blue Mountains Local Health District, Kingswood, New South Wales, Australia.

Summary: We report the case of a 65-year-old female who presented with symptomatic hypercalcaemia (corrected calcium of 4.57 mmol/L) with confusion, myalgias and abdominal discomfort. She had a concomitant metabolic alkalosis (pH 7. Read More

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http://dx.doi.org/10.1530/EDM-20-0028DOI Listing

Hypokalemia: A Curious Case in a Young Woman.

J Appl Lab Med 2020 May 12. Epub 2020 May 12.

Department of Clinical Biochemistry, Lancashire Teaching Hospitals NHS Foundation Trust, Lancashire, UK.

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http://dx.doi.org/10.1093/jalm/jfaa046DOI Listing

Idiopathic Carpal Spasm (Trousseau's Sign) After Intraoperative Arm Tourniquet Inflation in an Intubated Patient.

Cureus 2020 Apr 4;12(4):e7543. Epub 2020 Apr 4.

Plastic Surgery, St. James's Hospital, Dublin, IRL.

We present a case of a 38-year-old male who sustained a laceration from a knife to the volar aspect of his left index and middle fingers. He had clinical injury to his flexor digitorum profundus tendons to both digits. He underwent operative exploration and repair of the tendons under general anaesthetic. Read More

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http://dx.doi.org/10.7759/cureus.7543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198088PMC

Multiple acid-base and electrolyte disturbances upregulate NBCn1, NBCn2, IRBIT and L-IRBIT in the mTAL.

J Physiol 2020 May 2. Epub 2020 May 2.

Key Laboratory of Molecular Biophysics of Ministry of Education, School of Life Science & Technology, Huazhong University of Science & Technology, Wuhan, Hubei, 430074, China.

Key Points: The roles of the Na /HCO cotransporters NBCn1 and NBCn2 as well as their activators IRBIT and L-IRBIT in the regulation of the mTAL transport of NH , HCO , and NaCl are investigated. Dietary challenges of NH Cl, NaHCO , or NaCl all increase the abundance of NBCn1 and NBCn2 in the outer medulla. The three challenges generally produce parallel increases in the abundance of IRBIT and L-IRBIT in the outer medulla. Read More

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http://dx.doi.org/10.1113/JP279009DOI Listing

The Renal Physiology of Pendrin-Positive Intercalated Cells.

Physiol Rev 2020 Jul;100(3):1119-1147

Departments of Medicine and Physiology, Emory University School of Medicine, Atlanta, Georgia; and Department of Medicine, University of Florida, Gainesville, Florida.

Intercalated cells (ICs) are found in the connecting tubule and the collecting duct. Of the three IC subtypes identified, type B intercalated cells are one of the best characterized and known to mediate Cl absorption and HCO secretion, largely through the anion exchanger pendrin. This exchanger is thought to act in tandem with the Na-dependent Cl/HCO exchanger, NDCBE, to mediate net NaCl absorption. Read More

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http://dx.doi.org/10.1152/physrev.00011.2019DOI Listing

[Progress of research on the role of CLCNKB gene in classical Bartter syndrome].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 May;37(5):573-577

Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, China.

Bartter syndrome is an inherited metabolic disorder characterized by hypokalemic alkalosis and high rennin-angiotensin-aldosteronism which can occur at all ages but mainly in childhood. Classical Bartter syndrome is caused by loss-of-function variants in the gene encoding basolateral chloride channel ClC-Kb (CLCNKB), which is a common type of Bartter syndrome characterized with diverse clinical manifestations ranging from severe to very mild. This article reviews the function and mechanism of CLCNKB variants in Chinese population and the genotype-phenotype correlation of CLCNKB variants in classical Bartter syndrome. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.05.020DOI Listing

Study of Acid-Base Disorders and Biochemical Findings of Patients in a Tertiary Care Hospital: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2019 Nov-Dec;57(220):432-436

Department of Biochemistry, Nobel Medical College Teaching Hospital, Biratnagar, Nepal.

Introduction: Acid base disorder is a condition characterized by alteration in blood pH by the imbalance between the components of blood leading to a life threatening situation. The main aim of this study was to find the prevalence of acid-base disorders and biochemical findings of such disorders in patients in a tertairy care hospital.

Methods: This descriptive cross-sectional study was conducted in Nobel Medical College Teaching Hospital from 1st September, 2018 to 31st August, 2019. Read More

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Acute Kidney Injury Caused by Superior Mesenteric Artery Syndrome.

Case Rep Nephrol 2020 9;2020:8364176. Epub 2020 Apr 9.

Nephrology Unit, Medical Department, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Background: Superior mesenteric artery (SMA) syndrome is a rare cause of upper gastrointestinal obstruction leading to acute kidney injury (AKI).

Methods: We report a case of 23-year-old army personnel who presented with persistent vomiting leading to severe hypokalaemia, metabolic alkalosis, and acute kidney injury resulting in cardiorespiratory arrest.

Results: After successful resuscitation, he was supported with haemodialysis and aggressive electrolytes correction. Read More

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http://dx.doi.org/10.1155/2020/8364176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171609PMC

Tetraparesis with Major Hypokalaemia and Rhabdomyolysis Induced by Chronic Liquorice Ingestion.

Eur J Case Rep Intern Med 2020 9;7(4):001375. Epub 2020 Mar 9.

Chronic ingestion of liquorice induces a syndrome with findings similar to those for primary hyperaldosteronism. This is characterized by hypokalaemia, hypertension, metabolic alkalosis and suppression of the renin-aldosterone system. We describe a 30-year-old woman who, with a plasma potassium level of 1. Read More

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http://dx.doi.org/10.12890/2020_001375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162572PMC

Perioperative apnea in infants with hypertrophic pyloric stenosis: a systematic review.

Paediatr Anaesth 2020 Apr 16. Epub 2020 Apr 16.

Department of Paediatric Surgery, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: Infantile hypertrophic pyloric stenosis (IHPS) leads to excessive vomiting and metabolic alkalosis, which may subsequently cause apnea. Although it is generally assumed that metabolic derangements should be corrected prior to surgery to prevent apnea, the exact incidence of perioperative apneas in infants with IHPS and the association with metabolic alkalosis are unknown. We performed this systematic review to assess the incidence of apnea in infants with IHPS and to verify the possible association between apnea and metabolic alkalosis. Read More

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http://dx.doi.org/10.1111/pan.13879DOI Listing

Anaesthetic management for hiatal hernia repair in a child with Bartter's syndrome: A case report.

J Pak Med Assoc 2020 Apr;70(4):737-739

Department of Anaesthesiology, Aga Khan University, Karachi, Pakistan.

Bartter syndrome is a rare disorder characterized by reduced sodium chloride transport in the distal nephrons of the kidney. Its clinical features are renal salt wasting, hypokalemic metabolic alkalosis, elevated renin and aldosterone levels with normal or low blood pressure, polyuria, hypercalciuria and malnutrition. The pathophysiologic and biochemical changes in these patients should be kept in mind when considering anaesthetic management. Read More

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http://dx.doi.org/10.5455/JPMA.302642254DOI Listing

Gitelman syndrome associated with chondrocalcinosis and severe neuropathy: a novel heterozygous mutation in SLC12A3 gene.

Reumatismo 2020 Apr 10;72(1):67-70. Epub 2020 Apr 10.

Unit of Rheumatology, Università di Modena e Reggio Emilia, Modena.

Gitelman syndrome (GS) is an inherited salt-wasting tubulopathy characterized by hypocalciuria, hypokalemia, hypomagnesemia and metabolic alkalosis, due to inactivating mutations in the SLC12A3 gene. Symptoms may be systemic, neurological, cardiovascular, ophthalmological or musculoskeletal. We describe a 70 year-old patient affected by recurrent arthralgias, hypoesthesia and hyposthenia in all 4 limbs and severe hypokalemia, complicated by atrial flutter. Read More

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http://dx.doi.org/10.4081/reumatismo.2020.1255DOI Listing

Functional Study of Novel Bartter's Syndrome Mutations in ClC-Kb and Rescue by the Accessory Subunit Barttin Toward Personalized Medicine.

Front Pharmacol 2020 17;11:327. Epub 2020 Mar 17.

Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.

Type III and IV Bartter syndromes (BS) are rare kidney tubulopathies caused by loss-of-function mutations in the and genes coding respectively for the ClC-Kb chloride channels and accessory subunit barttin. ClC-K channels are expressed in the Henle's loop, distal convoluted tubule, and cortical collecting ducts of the kidney and contribute to chloride absorption and urine concentration. In our Italian cohort, we identified two new mutations in , G167V and G289R, in children affected by BS and previously reported genetic variants, A242E, a chimeric gene and the deletion of the whole . Read More

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http://dx.doi.org/10.3389/fphar.2020.00327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092721PMC

Acetazolamide Causes Worsening Acidosis in Uncompensated COPD Exacerbations: Increased Awareness Needed for Patient Safety.

Authors:
Jennifer L Cole

J Emerg Med 2020 Mar 30. Epub 2020 Mar 30.

Veterans Healthcare System of the Ozarks, Fayetteville, Arkansas.

Background: Acetazolamide has been studied extensively in post-hypercapnic alkalosis as a tool to facilitate ventilator weaning in chronic obstructive pulmonary disease (COPD). It has also been utilized to facilitate respiratory drive in nonmechanically ventilated patients with COPD. Although this is generally a forgiving intervention, providers must carefully select patients for this medication, as it can cause severe acidosis and deterioration of clinical status in severe COPD cases. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.01.019DOI Listing

SLC26A3 mutation in Turkish neonate and her sibling with congenital chloride diarrhea.

Turk Pediatri Ars 2020 9;55(1):76-78. Epub 2020 Mar 9.

Department of Child Health and Diseases, Karabük University Faculty of Medicine, Karabük, Turkey.

Congenital chloride diarrhea is a rare cause of severe infantile diarrhea with excessive chloride excretion. Mutations in the SLC26A3 gene cause congenital chloride diarrhea. It generally becomes apparent in the neonatal period and is characterized by electrolyte imbalances, metabolic alkalosis, and failure to thrive. Read More

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http://dx.doi.org/10.5152/TurkPediatriArs.2018.6929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096564PMC

Looking beyond Entecavir to discover Gitelman Syndrome in a 50 year-old man.

QJM 2020 Mar 28. Epub 2020 Mar 28.

Nephrology, Department of Translational Medical Sciences, University of Campania "L.Vanvitelli", Naples, Italy.

Background: Potassium (K+) is essential for cells functions and alterations of the normal plasmatic levels can be life-threatening. The kidney is crucial in maintaining K+ homeostasis, mainly by regulating its secretion in the urine. Hypokalemia is influenced by acid-base status and can be associated to both metabolic alkalosis or acidosis. Read More

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http://dx.doi.org/10.1093/qjmed/hcaa104DOI Listing

Spironolactone-furosemide combination therapy and acid-base disorders in liver cirrhosis patients
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Int J Clin Pharmacol Ther 2020 May;58(5):261-267

Objective: Respiratory alkalosis (RA) and dilutional hyperchloremic acidosis (DHA) are the most common acid-base balance (ABB) disorders in patients with liver cirrhosis. The aims of this study were to clarify whether RA develops in relation to DHA via respiratory compensation of metabolic acidosis and whether spironolactone in combination with low-dose furosemide - diuretics known to ameliorate DHA - positively affects RA in liver cirrhosis patients.

Materials And Methods: 59 patients with advanced cirrhosis were divided into two groups. Read More

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http://dx.doi.org/10.5414/CP203624DOI Listing

Unchanged cerebrovascular CO reactivity and hypercapnic ventilatory response during strict head-down tilt bed rest in a mild hypercapnic environment.

J Physiol 2020 Mar 20. Epub 2020 Mar 20.

NASA Johnson Space Center, Houston, TX, USA.

Key Points: Carbon dioxide levels are mildly elevated on the International Space Station and it is unknown whether this chronic exposure causes physiological changes to astronauts. We combined ∼4 mmHg ambient with the strict head-down tilt bed rest model of spaceflight and this led to the development of optic disc oedema in one-half of the subjects. We demonstrate no change in arterialized , cerebrovascular reactivity to CO or the hypercapnic ventilatory response. Read More

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http://dx.doi.org/10.1113/JP279383DOI Listing

Isolated nephrocalcinosis due to compound heterozygous mutations in renal outer medullary potassium channel.

CEN Case Rep 2020 Mar 17. Epub 2020 Mar 17.

Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Identification of a monogenic etiology is possible in a proportion of patients with childhood-onset nephrolithiasis or nephrocalcinosis. Bartter syndrome (BS), a hereditary tubulopathy characterized by polyuria, hypokalemic alkalosis and growth retardation that rarely presents with isolated nephrocalcinosis. Patients with defect in renal outer medullary potassium channel, encoded by the KCNJ1 gene causing BS type 2, typically present during the neonatal period. Read More

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http://dx.doi.org/10.1007/s13730-020-00464-yDOI Listing

DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels.

J Biol Chem 2020 May 17;295(18):5970-5983. Epub 2020 Mar 17.

Department of Cellular Neurophysiology, Hannover Medical School, 30625 Hannover, Germany

Barttin is the accessory subunit of the human ClC-K chloride channels, which are expressed in both the kidney and inner ear. Barttin promotes trafficking of the complex it forms with ClC-K to the plasma membrane and is involved in activating this channel. Barttin undergoes post-translational palmitoylation that is essential for its functions, but the enzyme(s) catalyzing this post-translational modification is unknown. Read More

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http://dx.doi.org/10.1074/jbc.RA119.011049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196637PMC
May 2020
4.573 Impact Factor

Endogenous brain-sparing responses in brain pH and PO in a rodent model of birth asphyxia.

Acta Physiol (Oxf) 2020 Mar 16:e13467. Epub 2020 Mar 16.

Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences, University of Helsinki, Helsinki, Finland.

Aim: To study brain-sparing physiological responses in a rodent model of birth asphyxia which reproduces the asphyxia-defining systemic hypoxia and hypercapnia.

Methods: Steady or intermittent asphyxia was induced for 15-45 minutes in anaesthetized 6- and 11-days old rats and neonatal guinea pigs using gases containing 5% or 9% O plus 20% CO (in N ). Hypoxia and hypercapnia were induced with low O and high CO respectively. Read More

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http://dx.doi.org/10.1111/apha.13467DOI Listing

Inter-individual variability in freshwater tolerance is related to transcript level differences in gill and posterior kidney of European sea bass.

Gene 2020 May 9;741:144547. Epub 2020 Mar 9.

Univ Montpellier, MARBEC (CNRS, IFREMER, IRD, UM), Montpellier, France. Electronic address:

Acclimation to low salinities is a vital physiological challenge for euryhaline fish as the European sea bass Dicentrarchus labrax. This species undertakes seasonal migrations towards lagoons and estuaries where a wide range of salinity variations occur along the year. We have previously reported intraspecific differences in freshwater tolerance, with an average 30% mortality rate. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144547DOI Listing

A Case of Bartter's Syndrome Presenting in Adulthood.

Iran J Kidney Dis 2020 01;14(1):65-67

.

Bartter's syndrome is a rare disorder usually presenting antenatal or in childhood and is characterized by hypokalemia, metabolic alkalosis, hyperaldosteronism and normal blood pressure. We report a case of adult-onset Bartter's syndrome in a 38 year old male who presented with lower limb weakness. Read More

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January 2020

Splicing Characterization of Variants in Four Patients With Type III Bartter Syndrome.

Front Genet 2020 21;11:81. Epub 2020 Feb 21.

Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.

Objective: Type III Bartter syndrome (BS) is caused by loss-of-function mutations in the gene encoding basolateral chloride channel ClC-Kb (), and is characterized by hypokalemic metabolic alkalosis and hyperreninemic hyperaldosteronism. Here, we investigated the molecular defects in four Chinese children with clinical manifestations of Bartter syndrome.

Methods: The genomic DNA of the four patients was screened for gene variations using whole-exome sequencing (WES). Read More

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http://dx.doi.org/10.3389/fgene.2020.00081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047732PMC
February 2020

Acid-base effects of continuous infusion furosemide in clinically stable surgical ICU patients: an analysis based on the Stewart model.

Clin Exp Nephrol 2020 Jun 9;24(6):541-546. Epub 2020 Mar 9.

Department of Pharmacy, The University of Rochester Medical Center, 601 Elmwood Ave., Rochester, NY, 14642, USA.

Objectives: We sought to test the strength of correlation between predicted and observed systemic acid-base status based on the Stewart model equations during continuous infusion (CI) furosemide therapy.

Design, Setting And Participants: This was a prospective, single-center, observational study conducted in the Surgical ICU of a large academic medical center. Ten critically ill patients who received CI furosemide were included. Read More

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http://dx.doi.org/10.1007/s10157-020-01867-yDOI Listing

Electrolyte and acid-base disorders in cancer patients and its impact on clinical outcomes: evidence from a real-world study in China.

Ren Fail 2020 Nov;42(1):234-243

Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.

This study aims to delineate the incidence of electrolyte and acid-base disorders (EAD) in cancer patients, to figure out the risk factors of EAD, then to assess the impact of EAD on patients' in-hospital clinical outcomes. Patients with the diagnosis of malignancies hospitalized during 1 October 2014 and 30 September 2015 were recruited in Zhongshan Hospital, Fudan University in Shanghai of China. Demographic characteristics, comorbidities, and clinical data, including survival, length of stay and hospital cost, were extracted from the electronic medical record system. Read More

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http://dx.doi.org/10.1080/0886022X.2020.1735417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067195PMC
November 2020
0.775 Impact Factor

Role of electrolyte abnormalities and unmeasured anions in the metabolic acid-base abnormalities in dogs with parvoviral enteritis.

J Vet Intern Med 2020 Mar 4;34(2):857-866. Epub 2020 Mar 4.

Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa.

Background: The strong ion model (SIM) is an alternative paradigm in the characterization of acid-base disturbances particularly in complex disorders.

Hypothesis/objectives: To compare the acid-base changes in dogs with parvoviral enteritis (PE) using the Henderson-Hasselbalch (HH) approach, with 2 strong ion approaches.

Animals: Forty-four dogs with PE, and 16 age-matched control dogs. Read More

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http://dx.doi.org/10.1111/jvim.15749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096617PMC

Persistent hypokalemia due to a rare mutation in gitelman's syndrome.

Saudi J Kidney Dis Transpl 2020 Jan-Feb;31(1):259-262

Department of Nephrology, Evangelismos Hospital, Athens, Greece.

Chronic hypokalemia is the main finding in patients with Gitelman's syndrome (GS). GS, a variant of Bartter's syndrome, is an autosomal recessive renal disorder characterized by hypokalemia, hypomagnesemia, metabolic alkalosis, and hypocalciuria. GS is caused by inactivating mutations in the thiazide-sensitive sodium-chloride cotransporter gene. Read More

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http://dx.doi.org/10.4103/1319-2442.279949DOI Listing

Complications of Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy: An Observational Study.

Blood Purif 2020 Mar 3:1-9. Epub 2020 Mar 3.

Adult Intensive Care Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland,

Introduction: Regional citrate anticoagulation (RCA) is the recommended anticoagulation modality for continuous renal replacement therapy (CRRT). RCA was associated with a low rate of complications in randomized controlled trials. However, little is known about the type and rate of complications in real life. Read More

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http://dx.doi.org/10.1159/000506253DOI Listing

A rare case of severe hypertension with hypokalemic metabolic alkalosis in a 14-year-old girl: Answers.

Pediatr Nephrol 2020 Mar 2. Epub 2020 Mar 2.

Department of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.

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http://dx.doi.org/10.1007/s00467-020-04509-3DOI Listing

A rare cause of severe hypertension with hypokalemic metabolic alkalosis in a 14-year-old girl: Questions.

Pediatr Nephrol 2020 Mar 2. Epub 2020 Mar 2.

Department of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.

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http://dx.doi.org/10.1007/s00467-020-04508-4DOI Listing

Sodium Fate after Sodium Bicarbonate Infusion: Influence of Altered Acid-Base Status.

Am J Nephrol 2020 18;51(3):182-191. Epub 2020 Feb 18.

Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA,

Background: We have previously investigated the fate of administered bicarbonate infused as a hypertonic solution in animals with each of the 4 chronic acid-base disorders. Those studies did not address the fate of sodium, the coadministered cation.

Methods: We examined baseline total body water (TBW), Na+ space, HCO3- space, and urinary sodium and bicarbonate excretion after acute hypertonic NaHCO3 infusion (1-N solution, 5 mmol/kg body weight) in dogs with each of the 4 chronic acid-base disorders. Read More

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http://dx.doi.org/10.1159/000506274DOI Listing
February 2020

[Advance in genetic research on Gitelman syndrome].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Feb;37(2):205-208

Department of Pediatrics, the First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310003, China.

With an estimated incidence of 1/40 000 to 1/4000, Gitelman syndrome is the most common type of inherited renal tubular disease during adolescence or adulthood. Characteristic features of Gitelman syndrome include transient episodes of muscle cramps and fatigue, hypokalemia, hypomagnesemia, hypocalciuria, and metabolic alkalosis. Detection of SLC12A3 mutations, in conjunct with clinical manifestations, may confirm the diagnosis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.02.026DOI Listing
February 2020

Colistin-induced acquired Bartter-like syndrome: an unusual cause of meltdown.

BMJ Case Rep 2020 Feb 5;13(2). Epub 2020 Feb 5.

Medicine, All India Institute of Medical Sciences, New Delhi, India.

Colistin-induced nephrotoxicity is commonly associated with elevation of serum creatinine level or a reduction of urine output. Uncommonly, tubulopathy associated with colistin has been reported. Here we present a unique case of a 46-year-old man who developed polyuria, hypokalaemia, hypocalcaemia, hypomagnesemia and metabolic alkalosis after 3 days of therapy with intravenous colistimethate sodium. Read More

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http://dx.doi.org/10.1136/bcr-2019-232630DOI Listing
February 2020

Assessing intracellular pH regulation in H-ATPase-rich ionocytes in zebrafish larvae using ratiometric imaging.

J Exp Biol 2020 Mar 12;223(Pt 5). Epub 2020 Mar 12.

Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON KIN 6N5, Canada

The H-ATPase-rich (HR) cells of zebrafish larvae are a sub-type of ion-transporting cell located on the yolk sac epithelium that are responsible for Na uptake and H extrusion. Current models of HR cell ion transport mechanisms in zebrafish larvae are well established, but little is known about the involvement of the various ion transport pathways in regulating intracellular acid-base status. Here, a ratiometric imaging technique was developed and validated to monitor intracellular pH (pHi) continuously in larval zebrafish HR cells Gene knockdown or CRISPR/Cas9 knockout approaches were used to evaluate the roles of the two principal apical membrane acid excretory pathways, the Na/H exchanger (NHE3b; ) and the H-ATPase (). Read More

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http://dx.doi.org/10.1242/jeb.212928DOI Listing

Adrenocorticotropic Hormone-producing Extrapulmonary Small Cell Carcinoma of the Breast.

Cureus 2019 Dec 28;11(12):e6488. Epub 2019 Dec 28.

Department of Internal Medicine, University of Missouri, Columbia, USA.

Extrapulmonary small cell carcinoma (EPSCC) of the breast is a very rare tumor. Adrenocorticotropic hormone (ACTH) production from these tumors is extremely rare and seldom reported resulting in significant diagnostic and therapeutic challenges and delays. We present a case of a 38-year-old female who presented with a breast lump and was diagnosed with primary EPSCC of the breast. Read More

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http://dx.doi.org/10.7759/cureus.6488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984178PMC
December 2019

Metabolic alkalosis is related to delayed response to treatment of hypokalemia in non-surgical critically ill patients.

J Community Hosp Intern Med Perspect 2019 14;9(6):477-479. Epub 2019 Dec 14.

Nephrology and Renal Transplantation Unit, Fundación Valle del Lili, Universidad ICESI, Cali, Colombia.

: Potassium (K+) homeostasis is closely related to acid - base disorders. The aim of this study is to analyze the possible causes of hypokalemia non-surgical critically ill patients including acid - base disorders and its relationship with response to K+ supplementation. : We performed a retrospective cohort study of 122 consecutive non-surgical patients admitted to the Intensive Care Unit during July 2016 Patients were classified according to the presence of hypokalemia or not. Read More

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http://dx.doi.org/10.1080/20009666.2019.1700078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968578PMC
December 2019

Recurrent Metabolic Alkalosis in a Cystic Fibrosis Patient: Coexistence with Congenital Chloride Diarrhea.

J Pediatr Genet 2020 Mar 2;9(1):44-47. Epub 2019 Sep 2.

Pediatric Gastrohepatology Unit, University Hospital La Fe, Valencia, Spain.

Metabolic alkalosis is uncommon in infancy. Cystic fibrosis (CF) patients can develop dehydration because of sweat salt or gastrointestinal losses; with the correct salt supplementation, the electrolyte alterations can be reversed. Here, we present a CF patient with recurrent metabolic alkalosis, initially oriented as pseudo-Bartter's syndrome. Read More

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http://dx.doi.org/10.1055/s-0039-1695059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976311PMC

Effect of half-molar sodium lactate infusion on biochemical parameters in critically ill patients.

Med Intensiva 2020 Jan 20. Epub 2020 Jan 20.

Cátedra de Medicina Intensiva, Centro de Tratamiento Intensivo, Hospital de Clínicas Dr. Manuel Quintela, Facultad de Medicina, Universidad de la República (UdelaR), Montevideo, Uruguay.

Objective: To evaluate the impact of the infusion of sodium lactate 500ml upon different biochemical variables and intracranial pressure in patients admitted to the intensive care unit.

Design: A prospective experimental single cohort study was carried out.

Scope: Polyvalent intensive care unit of a university hospital. Read More

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http://dx.doi.org/10.1016/j.medin.2019.11.010DOI Listing
January 2020

Calcium-Alkali Syndrome Associated with Hypoparathyroidism Following Total Thyroidectomy.

Am J Nephrol 2020 22;51(2):160-167. Epub 2020 Jan 22.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan,

Background: Patients with permanent postsurgical hypoparathyroidism, a complication of total thyroidectomy, often require high calcium supplementation with vitamin D to maintain serum calcium levels. The epidemiology of calcium-alkali syndrome (CAS) in patients with hypoparathyroidism after total thyroidectomy remains unclear. This study aimed to investigate the incidence of hypercalcemia, renal impairment, metabolic alkalosis, and CAS in patients treated for presumed hypoparathyroidism after total thyroidectomy. Read More

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http://dx.doi.org/10.1159/000505718DOI Listing
January 2020

A Delphi Analysis to Reach Consensus on Preoperative Care in Infants with Hypertrophic Pyloric Stenosis.

Eur J Pediatr Surg 2020 Jan 20. Epub 2020 Jan 20.

Department of Pediatric Surgery, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam & Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Introduction:  Infantile hypertrophic pyloric stenosis (IHPS) is a common gastrointestinal condition that can lead to metabolic alkalosis and, if uncorrected, to respiratory complications. A standardized approach to correct metabolic derangements and dehydration may reduce time until pyloromyotomy while preventing potential respiratory complications. Such an evidence-based policy regarding preoperative care is absent. Read More

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http://dx.doi.org/10.1055/s-0039-3401987DOI Listing
January 2020

Metabolic alkalosis due to short bowel syndrome in a hemodialysis patient.

CEN Case Rep 2020 May 18;9(2):162-164. Epub 2020 Jan 18.

Department of Nephrology, Osaka Rosai Hospital, Sakai, Osaka, Japan.

A 53-year-old man on hemodialysis suffered from short bowel syndrome after subtotal colectomy and partial resection of the small intestine. Laboratory tests showed multiple electrolyte disorders and enlarged sodium and chloride ion (Cl) gaps despite treatment with large volume of sodium chloride replacement via central venous infusion. Blood gas analysis showed slightly high bicarbonate ion levels and metabolic alkalosis was suspected, which is uncommon in end stage kidney disease. Read More

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http://dx.doi.org/10.1007/s13730-020-00445-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148411PMC

Derangement of PaCO requires physician attention in acute carbon monoxide poisoning.

Hum Exp Toxicol 2020 May 13;39(5):642-652. Epub 2020 Jan 13.

Department of Emergency Medicine, Chonnam National University Medical School, Gwangju, South Korea.

The objective was to describe the prevalence of derangement of the partial pressure of arterial carbon dioxide (PaCO) and to determine the association between PaCO and adverse cardiovascular events (ACVEs) in carbon monoxide (CO)-poisoned patients. Additionally, we evaluated whether the derangement of PaCO was simply secondary to metabolic changes. This retrospective study included 194 self-breathing patients after CO poisoning with an indication for hyperbaric oxygen therapy and available arterial blood gas analysis at presentation and 6 h later. Read More

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http://dx.doi.org/10.1177/0960327119898720DOI Listing

Can Venous Blood Gas Be Used as an Alternative to Arterial Blood Gas in Intubated Patients at Admission to the Emergency Department? A Retrospective Study.

Open Access Emerg Med 2019 23;11:305-312. Epub 2019 Dec 23.

Department of Emergency Medicine, Medical University of Vienna, Vienna A-1090, Austria.

Objective: Blood gas analysis plays an important role in both diagnosis and subsequent treatment of critically ill patients in the emergency department and the ICU. Historically, arterial blood is predominantly used for blood gas analysis. The puncture is painful and complications may occur. Read More

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http://dx.doi.org/10.2147/OAEM.S228420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934126PMC
December 2019

Concomitance of Familial Mediterranean Fever and Gitelman syndrome in an adolescent.

Turk J Pediatr 2019 ;61(3):444-448

Departments of Pediatric Nephrology, Çukurova University Faculty of Medicine, Adana, Turkey.

Atmış B, Kışla-Ekinci RM, Melek E, Bişgin A, Yılmaz M, Anarat A, Karabay-Bayazıt A. Concomitance of Familial Mediterranean Fever and Gitelman syndrome in an adolescent. Turk J Pediatr 2019; 61: 444-448. Read More

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http://dx.doi.org/10.24953/turkjped.2019.03.021DOI Listing
January 2019

Food Products That May Cause an Increase in Blood Pressure.

Curr Hypertens Rep 2020 Jan 8;22(1). Epub 2020 Jan 8.

Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20/24, 40-027, Katowice, Poland.

Purpose Of Review: To review latest reports of the food products which might increase blood pressure and therefore might participate in the pathogenesis of hypertension.

Recent Findings: Results of clinical study suggest that consumption of high-sodium food leads to transient increase in plasma sodium concentration. This is accompanied by blood pressure increase. Read More

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http://dx.doi.org/10.1007/s11906-019-1007-yDOI Listing
January 2020