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    3111 results match your criteria Metabolic Alkalosis

    1 OF 63

    Perioperative Concerns for Profound Metabolic Alkalosis During Kidney Transplantation: A Case Report.
    Iran Red Crescent Med J 2016 Nov 2;18(11):e38728. Epub 2016 Oct 2.
    Department of Anesthesiology and Pain Medicine, Gachon University, Gil Medical Center, Incheon, South Korea.
    Introduction: Profound metabolic alkalosis is an uncommon consideration for the anesthetic management of kidney transplantation. Serum total carbon dioxide content and complex electrolyte abnormalities might be important diagnostic clues for the presence of metabolic alkalosis in the absence of arterial blood gas analysis.

    Case Presentation: A 34-year-old female visited Gachon University Gil Medical Center, Incheon, South Korea during year 2015. Read More

    Experiences with Continuous Venovenous Hemofiltration using 18mmol/L predilution Citrate anticoagulation and a Phosphate Containing Replacement Solution.
    Indian J Crit Care Med 2017 Jan;21(1):11-16
    Department of Intensive Care, Intensive Care Unit, Queen Elizabeth Hospital, Kowloon, Hong Kong.
    Context: Regional citrate anticoagulation for continuous renal replacement therapy is associated with a longer filter-life, less bleeding events and improved mortality. Problems associated with using Prismocitrate 10/2 solution in continuous renal replacement therapy, include hypomagnesemia, hypophosphatemia and the need for additional bicarbonate infusion.

    Aims: This study uses the new Prismocitrate 18/0 solution for improved buffer balance and Phoxilium solution for a more favourable electrolyte profile. Read More

    Dynamics of acid-base and hematological regulation in day 15 chicken embryos (Gallus gallus domesticus) exposed to graded hypercapnia and hypoxia.
    Respir Physiol Neurobiol 2017 Feb 9;239:55-63. Epub 2017 Feb 9.
    Developmental Integrative Biology, Department of Biological Sciences, University of North Texas, 1155 Union Circle #305220, Denton, TX 76203, USA.
    Most experiments examining acid-base regulation of chicken embryos have employed static, single time point measurements rather than dynamic, multiple time point measurements that might reveal additional components of developing acid-base regulation. Thus, we studied blood acid-base balance and hematology of day 15 chicken embryos under 24h exposure to graded hypercapnia (1%-7% CO2) accompanied by graded hypoxia (20% O2 down to 13% O2). Across all hypercapnic/hypoxic environments, respiratory acidosis occurred 2h after exposure in proportion to the magnitude of hypercapnia. Read More

    Corrected to uncorrected? The metabolic conundrum of hypertrophic pyloric stenosis.
    J Pediatr Surg 2017 Jan 28. Epub 2017 Jan 28.
    Division of Pediatric General Surgery, IWK Health Centre; Dalhousie University; Halifax, Nova Scotia, Canada.
    Objectives: The purpose of this study was to evaluate factors associated with repeat blood testing after establishment of normal metabolic parameters and factors associated with reversal of metabolic correction back an uncorrected form in preoperative management of infants with Hypertrophic Pyloric Stenosis (HSP).

    Methods: A retrospective review of infants with HSP undergoing repeat serum chemistries after already having normal labs were identified. Variables associated with repeating normal bloodwork and reversion of normal to abnormal labs were identified. Read More

    Gitelman syndrome in a South African family presenting with hypokalaemia and unusual food cravings.
    BMC Nephrol 2017 Jan 26;18(1):38. Epub 2017 Jan 26.
    Division of Nephrology, Department of Medicine, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.
    Background: Gitelman syndrome (GS) is an autosomal recessive renal tubular disorder characterised by renal salt wasting with hypokalaemia, metabolic alkalosis, hypomagnesaemia and hypocalciuria. It is caused by mutations in SLC12A3 encoding the sodium-chloride cotransporter on the apical membrane of the distal convoluted tubule. We report a South African family with five affected individuals presenting with hypokalaemia and unusual food cravings. Read More

    [Gitelman´s syndrome as common cause of hypokalemia and hypomagnesemia].
    Vnitr Lek 2016 ;62(Supplementum 6):78-83
    The Gitelman syndrome (GS) is an autosomal recessive disorder characterized by hypokalemic metabolic alkalosis and presence of hypocalciuria and hypomagnesemia. It is one of the most common congenital "salt-wasting" tubulo-pathies, where the impairment of function of the Na+-Cl- cotransporter (NCCT) in the distal convoluted tubule is primary and hypokalemia secondary. Hypomagnesemia is caused by the impairment of magnesium reabsorption through TRPM6 channel which is located just by NCCT. Read More

    [Metabolic acidosis in chronic kidney disease].
    Vnitr Lek 2016 ;62(Supplementum 6):30-39
    Metabolic acidosis (MAC) is a constant symptom of chronic kidney disease (CKD) in advanced stages. However, its onset and degree do not depend only on the decrease of glomerular filtration but also on tubular functions. Therefore, in patients with predominant tubulointerstitial involvement it may already appear in earlier stages of CKD, usually as MAC with normal anion gap. Read More

    [[Na+] - [Cl-] difference significantly contributes to acidemia in patients with liver cirrhosis].
    Vnitr Lek 2016 ;62(Supplementum 6):14-20
    Aim: To evaluate the role of strong ion difference (SID) in acid-base disorders in patients with liver disease.

    Patients And Methods: We evaluated the acid-base status in 11 patients with liver cirrhosis both by traditional and quantitative Stewart-Fencl methods.

    Results: Nine of eleven patients had pH within the norm, 2/11 had pH above 7. Read More

    Out of Warburg effect: An effective cancer treatment targeting the tumor specific metabolism and dysregulated pH.
    Semin Cancer Biol 2017 Jan 22. Epub 2017 Jan 22.
    Department of Therapeutic Research and Medicine Evaluation, National Institute of Health, Rome, Italy.
    As stated by Otto Warburg nearly a century ago, cancer is a metabolic disease, a fermentation caused by malfunctioning mitochondria, resulting in increased anabolism and decreased catabolism. Treatment should, therefore, aim at restoring the energy yield. To decrease anabolism, glucose uptake should be reduced (ketogenic diet). Read More

    Ectopic Cushing syndrome in small cell lung cancer: A case report and literature review.
    Thorac Cancer 2016 Nov 8. Epub 2016 Nov 8.
    Department of Thoracic Medical Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.
    Small cell lung cancer (SCLC) is a neuroendocrine tumor with the potential to secrete various peptides or hormones that can lead to paraneoplastic syndromes, such as Ectopic Cushing syndrome (ECS). Because of the aggressive nature of the syndrome and its atypical features, ECS in small-cell lung cancer is difficult to diagnose and has a poor prognosis. We report a case of a 74-year-old male patient who presented with severe hypokalemia, proximal muscle weakness, peripheral edema, metabolic alkalosis, and worsening hyperglycemia. Read More

    A novel SLC12A1 gene mutation associated with hyperparathyroidism, hypercalcemia, nephrogenic diabetes insipidus, and nephrocalcinosis in four patients.
    Bone 2017 Jan 14;97:121-125. Epub 2017 Jan 14.
    Center for Endocrinology, Diabetes and Metabolism, Division of Endocrinology, Children's Hospital Los Angeles, Los Angeles, CA, United States; Keck School of Medicine of University of Southern California, Los Angeles, CA, United States. Electronic address:
    Solute Carrier Family 12 member 1 (SLC12A1) gene encodes the sodium-potassium-chloride co-transporter (NKCC2) at the apical membrane of the thick ascending loop of Henle (TAL). Bartter's syndrome (BS) type I is a rare, autosomal recessive, renal tubular disorder associated with mutation of the SLC12A1 gene. Presenting features include: hypokalemic metabolic alkalosis, hypercalciuria and nephrocalcinosis. Read More

    Hypokalemic Paralysis Complicated by Concurrent Hyperthyroidism and Hyperaldosternoism: A Case Report.
    Am J Case Rep 2017 Jan 4;18:12-16. Epub 2017 Jan 4.
    Department of Medicine, Fu-Jen Catholic University School of Medicine, Taipei, Taiwan.
    BACKGROUND Thyrotoxic periodic paralysis (TPP) is commonly observed in patients with acute paralysis and hyperthyroidism. However, there is a possibility of secondary causes of hypokalemia in such a setting. CASE REPORT Herein, we present the case of a 38-year-old woman with untreated hypertension and hyperthyroidism. Read More

    Alkalosis in Critically Ill Patients with Severe Sepsis and Septic Shock.
    PLoS One 2017 3;12(1):e0168563. Epub 2017 Jan 3.
    Institute for Clinical Sciences Malmö, Lund University, Lund, Sweden.
    Introduction: Although metabolic alkalosis is a common occurrence in intensive care units (ICUs), no study has evaluated its prevalence or outcomes in patients with severe sepsis or septic shock.

    Methods: This is a retrospective cohort study of critically ill patients suffering from severe sepsis and septic shock admitted to the ICUs of Halmstad and Varberg County hospitals. From 910 patient records, 627 patients met the inclusion criteria. Read More

    A novel mutation of CLCNKB in a Korean patient of mixed phenotype of Bartter-Gitelman syndrome.
    Korean J Pediatr 2016 Nov 30;59(Suppl 1):S103-S106. Epub 2016 Nov 30.
    Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
    Bartter syndrome (BS) is an inherited renal tubular disorder characterized by low or normal blood pressure, hypokalemic metabolic alkalosis, and hyperreninemic hyperaldosteronism. Type III BS is caused by loss-of-function mutations in CLCNKB encoding basolateral ClC-Kb. The clinical phenotype of patients with CLCNKB mutations has been known to be highly variable, and cases that are difficult to categorize as type III BS or other hereditary tubulopathies, such as Gitelman syndrome, have been rarely reported. Read More

    Gitelman syndrome: consensus and guidance from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
    Kidney Int 2017 Jan;91(1):24-33
    Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Centre d'Investigation Clinique, Paris, France; Centre de Référence des Maladies Rénales Héréditaires de l'Enfant et de l'Adulte, Paris, France.
    Gitelman syndrome (GS) is a rare, salt-losing tubulopathy characterized by hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria. The disease is recessively inherited, caused by inactivating mutations in the SLC12A3 gene that encodes the thiazide-sensitive sodium-chloride cotransporter (NCC). GS is usually detected during adolescence or adulthood, either fortuitously or in association with mild or nonspecific symptoms or both. Read More

    Surviving Without Oxygen: How Low Can the Human Brain Go?
    High Alt Med Biol 2016 Dec 21. Epub 2016 Dec 21.
    1 Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales , Glamorgan, United Kingdom .
    Bailey, Damian M., Christopher K. Willie, Ryan L. Read More

    [Clinical evaluation of acid-base status: Henderson-Hasselbalch, or Stewart-Fencl approach?]
    Cas Lek Cesk 2016 ;155(7):365-369
    Two approaches have been used in clinical evaluation the acid-base status: traditional (bicarbonate-centered) is based on the Henderson-Hasselbalch equation complemented by calculation of the anion gap, and more recent quantitative approach proposed by Stewart and Fencl. The latter method defines the three independent variables, which regulate pH. These include: the difference between the sum of charges carried by strong plasma cations and anions termed the strong ion difference - SID (decrease causes acidosis, and vice versa); the total concentration of the weak non-volatile acids [Atot] (inorganic phosphate and albumin, decrease causes alkalosis and vice versa), and pCO2. Read More

    Acquired Bartter syndrome following gentamicin therapy.
    Indian J Nephrol 2016 Nov-Dec;26(6):461-463
    Department of Microbiology, Institute of Medical Science, BHU, Varanasi, Uttar Pradesh, India.
    Aminoglycoside nephrotoxicity may manifest as nonoliguric renal failure or tubular dysfunction, such as Fanconi-like syndrome, Bartter-like syndrome (BS), or distal renal tubular acidosis. We report a case who developed severe renal tubular dysfunction on the the 7(th) day of gentamicin therapy, resulting in metabolic alkalosis, refractory hypokalemia, hypocalcemia, hypomagnesemia, and polyuria. The patient was diagnosed as a case of transient BS associated with gentamicin exposure. Read More

    Mixed acid-base disorder secondary to topiramate use in traumatic brain injury.
    Indian J Nephrol 2016 Nov-Dec;26(6):452-454
    Department of Neurosurgery, Yashoda Hospitals, Secunderabad, Telangana, India.
    We report a case of a man with traumatic brain injury. He was started on to prophylactic topiramate which led to a mixed acid-base disorder. He had severe metabolic acidosis secondary to renal tubular acidification defect and respiratory alkalosis secondary to hyperventilation. Read More

    A Quick Reference on Respiratory Alkalosis.
    Vet Clin North Am Small Anim Pract 2017 Mar 8;47(2):181-184. Epub 2016 Dec 8.
    Department of Surgical Sciences, University of Wisconsin - Madison, 2015 Linden Drive, Madison, WI 53706, USA. Electronic address:
    Respiratory alkalosis, or primary hypocapnia, occurs when alveolar ventilation exceeds that required to eliminate the carbon dioxide produced by tissues. Concurrent decreases in Paco2, increases in pH, and compensatory decreases in blood HCO3(-) levels are associated with respiratory alkalosis. Respiratory alkalosis can be acute or chronic, with metabolic compensation initially consisting of cellular uptake of HCO3(-) and buffering by intracellular phosphates and proteins. Read More

    Adrenocortical carcinoma, an unusual cause of secondary hypertension.
    BMJ Case Rep 2016 Dec 7;2016. Epub 2016 Dec 7.
    Department of Endocrinology, Hospital Regional Licenciado Adolfo Lopez Mateos, Ciudad de Mexico, Mexico.
    We present the case of a female patient aged 39 years who was admitted to our hospital due to hypertension, severe hypokalaemia and metabolic alkalosis; physical examination was remarkable for plethoric moon face, centripetal obesity and bilateral lower extremity oedema. She was admitted for intravenous potassium replacement and further assessment of hypertension and associated clinical findings. Laboratory testing showed increased levels of aldosterone, renin, cortisol, testosterone and androstenedione. Read More

    Vertebral Subluxation Repair in a Pet Goat.
    Vet Surg 2017 Jan 7;46(1):81-88. Epub 2016 Dec 7.
    Department of Anaesthesiology and Perioperative Intensive-Care Medicine, University of Veterinary Medicine, Vienna, Austria.
    Objectives: To describe the perioperative management, including surgery, anesthesia, metabolic derangements, and physiotherapy, in a goat referred for paraparesis secondary to a road traffic accident.

    Study Design: Case report.

    Animals: 2-year-old mixed breed dwarf 44 kg female pet goat. Read More

    A Quick Reference on Metabolic Alkalosis.
    Vet Clin North Am Small Anim Pract 2017 Mar 1;47(2):197-200. Epub 2016 Dec 1.
    Lois Bates Acheson Veterinary Teaching Hospital, Magruder Hall, Oregon State University, 700 Southwest 30th Street, Corvallis, OR 97331, USA.
    Metabolic alkalemia is characterized by an increase in bicarbonate concentration and base excess, an increase in pH, and a compensatory increase in carbon dioxide pressure. This article outlines indications for analysis, reference ranges, causes, and clinical signs of metabolic alkalosis. Algorithms for evaluation of patients with acid-base disorders and metabolic alkalosis are included. Read More

    Long-term follow-up of composite bladder augmentation incorporating stomach in a multi-institutional cohort of patients with cloacal exstrophy.
    J Pediatr Urol 2016 Oct 28. Epub 2016 Oct 28.
    Division of Pediatric Urology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA.
    Introduction: Composite bladder augmentation, incorporating gastric and bowel segments, has the theoretical advantage of metabolic neutrality while potentially avoiding the morbidities of gastrocystoplasty, such as hematuria-dysuria syndrome. The most common indication for this operation is a paucity of bowel, such as in cloacal exstrophy. Despite several early descriptive studies of this technique, there are no reports, to date, of long-term follow-up in this population. Read More

    Implementation of a Simplified Regional Citrate Anticoagulation Protocol for Post-Dilution Continuous Hemofiltration Using a Bicarbonate Buffered, Calcium Containing Replacement Solution.
    Blood Purif 2016 19;42(4):349-355. Epub 2016 Nov 19.
    Critical Care and Perioperative Medicine Research Group, William Harvey Research Institute, Queen Mary University of London, London, UK.
    Background/aims: Recent updates to the Nikkiso Aquarius continuous renal replacement therapy (CRRT) platform allowed us to develop a post-dilution protocol for regional citrate anticoagulation (RCA) using standard bicarbonate buffered, calcium containing replacement solution with acid citrate dextrose formula-A as a citrate source. Our objective was to demonstrate that the protocol was safe and effective.

    Methods: Prospective audit of consecutive patients receiving RCA for CRRT within intensive care unit, who were either contraindicated to heparin or had poor filter lifespan (<12 h for 2 consecutive filters) on heparin. Read More

    Secondary elements of blood pH variation can influence the effort effectiveness based on adaptive changes within a group of elite athletes.
    Clujul Med 2016 20;89(4):506-512. Epub 2016 Oct 20.
    Epidemiology Department, University of Medicine and Pharmacy Tîrgu Mureş, Romania.
    Aim: pH is the direct indicator of the body reaction following the activities performed. Establishing precise correlations between pH and blood biochemical parameters might support the balancing of values during periods of marked physical activity.

    Method: We conducted a case study in a group of elite rowers. Read More

    WNK signalling pathways in blood pressure regulation.
    Cell Mol Life Sci 2016 Nov 4. Epub 2016 Nov 4.
    Division of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, CB2 2QQ, UK.
    Hypertension (high blood pressure) is a major public health problem affecting more than a billion people worldwide with complications, including stroke, heart failure and kidney failure. The regulation of blood pressure is multifactorial reflecting genetic susceptibility, in utero environment and external factors such as obesity and salt intake. In keeping with Arthur Guyton's hypothesis, the kidney plays a key role in blood pressure control and data from clinical studies; physiology and genetics have shown that hypertension is driven a failure of the kidney to excrete excess salt at normal levels of blood pressure. Read More

    The Warburg Effect and the Hallmarks of Cancer.
    Anticancer Agents Med Chem 2017 ;17(2):164-170
    Al-Ghad International College for Applied Medical Sciences, Al-Madinah Al-Munawarah, KSA, Center for Evolution and Cancer, University of California San Francisco, San Francisco, CA,United States.
    It is a longstanding debate whether cancer is one disease or a set of very diverse diseases. The goal of this paper is to suggest strongly that most of (if not all) the hallmarks of cancer could be the consequence of the Warburg's effect. As a result of the metabolic impairment of the oxidative phosphorylation, there is a decrease in ATP concentration. Read More

    Acquired Gitelman Syndrome in an Anti-SSA Antibody-positive Patient with a SLC12A3 Heterozygous Mutation.
    Intern Med 2016;55(21):3201-3204. Epub 2016 Nov 1.
    Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan.
    A 36-year-old woman developed hypokalemic metabolic alkalosis after anti SS-A antibody was found to be positive. Diuretic loading test results were compatible with Gitelman syndrome (GS). The patient had a heterozygous mutation in SLC12A3, which encodes for thiazide-sensitive NaCl cotransporter (NCCT). Read More

    Fluid and ion transfer across the blood-brain and blood-cerebrospinal fluid barriers; a comparative account of mechanisms and roles.
    Fluids Barriers CNS 2016 Oct 31;13(1):19. Epub 2016 Oct 31.
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK.
    The two major interfaces separating brain and blood have different primary roles. The choroid plexuses secrete cerebrospinal fluid into the ventricles, accounting for most net fluid entry to the brain. Aquaporin, AQP1, allows water transfer across the apical surface of the choroid epithelium; another protein, perhaps GLUT1, is important on the basolateral surface. Read More

    The influence of sodium bicarbonate on maximal force and rates of force development in the triceps surae and brachii during fatiguing exercise.
    Exp Physiol 2016 Nov;101(11):1383-1391
    Sport and Exercise Science, School of Science and Health, Western Sydney University, Sydney, New South Wales, Australia.
    New Findings: What is the central question of this study? Does metabolic alkalosis in humans, induced by sodium bicarbonate, affect rates of skeletal muscle fatigue differentially in muscle groups composed predominately of slow- and fast-twitch fibres? What is the main finding and its importance? Sodium bicarbonate exhibited no effect on the fatigue profile observed between triceps surae and brachii muscle groups during and after 2 min of tetanic stimulation. For the first time in exercising humans, we have profiled the effect of sodium bicarbonate on the voluntary and involuntary contractile characteristics of muscle groups representative of predominately slow- and fast-twitch fibres. The effect of metabolic alkalosis on fibre-specific maximal force production and rates of force development (RFD) has been investigated previously in animal models, with evidence suggesting an improved capacity to develop force rapidly in fast- compared with slow-twitch muscle. Read More

    Cryptic exon activation in SLC12A3 in Gitelman syndrome.
    J Hum Genet 2017 Feb 27;62(2):335-337. Epub 2016 Oct 27.
    Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
    Gitelman syndrome (GS) is an autosomal recessive renal tubulopathy characterized by hypokalemic metabolic alkalosis with hypocalciuria and hypomagnesemia. GS clinical symptoms range from mild weakness to muscular cramps, paralysis or even sudden death as a result of cardiac arrhythmia. GS is caused by loss-of-function mutations in the solute carrier family 12 member 3 (SLC12A3) gene, but molecular mechanisms underlying such a wide range of symptoms are poorly understood. Read More

    A new peritoneal dialysis fluid for Japanese patients: a randomized non-inferiority clinical trial of safety and efficacy.
    Clin Exp Nephrol 2016 Oct 25. Epub 2016 Oct 25.
    Therapeutic Area, Baxter Healthcare (Asia) Pte Ltd, Singapore, Singapore.
    Background: We report here two new peritoneal dialysis fluids (PDFs) for Japan [BLR 250, BLR 350 (Baxter Limited, Japan)]. The PDFs use two-chamber systems, and have bicarbonate and lactate buffer to a total of 35 mmol/L. In separate trials, the new PDFs were compared to two "standard" systems [PD-4, PD-2 (Baxter Limited, Japan)]. Read More

    The Effect of Supplemental Oxygen in Obesity Hypoventilation Syndrome.
    J Clin Sleep Med 2016 Oct 15;12(10):1379-1388. Epub 2016 Oct 15.
    Department of Medicine, Section of Pulmonary and Critical Care, University of Chicago, Chicago, IL.
    Study Objectives: Low flow supplemental oxygen is commonly prescribed to patients with obesity hypoventilation syndrome (OHS). However, there is a paucity of data regarding its efficacy and safety. The objective of this study was to assess the medium-term treatment efficacy of adding supplemental oxygen therapy to commonly prescribed treatment modalities in OHS. Read More

    Proximal duodenoileal anastomosis for treatment of small intestinal obstruction and volvulus in a green iguana (Iguana iguana).
    J Am Vet Med Assoc 2016 Nov;249(9):1061-1066
    CASE DESCRIPTION A 13-year-old female green iguana (Iguana iguana) was examined because of a 6-day history of vomiting, anorexia, and lethargy and a 4-day history of decreased fecal and urate output. CLINICAL FINDINGS Physical examination revealed a distended abdomen, signs of depression, pallor, tachycardia, harsh lung sounds, and vomiting. Abdominal radiographs revealed gas distention of the stomach and small intestine with fluid lines evident on the lateral view. Read More

    Gitelman's syndrome presenting with hypocalcemic tetany and hypokalemic periodic paralysis.
    Saudi J Kidney Dis Transpl 2016 Sep-Oct;27(5):1026-1028
    Department of Nephrology, Sawai Man Singh Hospital, Jaipur, Rajasthan, India.
    Gitelman's syndrome is an autosomal recessive renal tubular disorder characterized by hypomagnesemia, hypokalemia, hypocalciuria, and metabolic alkalosis. Hypocalcemic tetany as a presentation of Gitelman's syndrome has rarely been reported in literature. We report a rare case of Gitelman's syndrome presenting with hypocalcemic tetany along with hypokalemic periodic paralysis. Read More

    [Disorders of the acid-base balance and the anion gap].
    Dtsch Med Wochenschr 2016 Oct 17;141(21):1549-1554. Epub 2016 Oct 17.
    The regulation of the acid-base balance and pH is critical for the organism. The most important buffer system is CO2 / HCO3(-). The kidney controls systemic bicarbonate and therefore the metabolic regulation and the lung is relevant for respiratory regulation by an effective CO2 elimination. Read More

    Acetazolamide Therapy for Metabolic Alkalosis in Pediatric Intensive Care Patients.
    Pediatr Crit Care Med 2016 Dec;17(12):e551-e558
    1Division of Neonatal Critical Care, Gregorio Marañón General University Hospital, Madrid, Spain.2Department of Pediatrics, Getafe University Hospital, Universidad Europea de Madrid, Research Network on Maternal and Child Health and Development, Getafe, Madrid, Spain.3Red SAMID, Spain.4Division of Pediatric Critical Care, Gregorio Marañon General University Hospital, Madrid, Spain.5Hospital Pharmacy Service, Gregorio Marañón General University Hospital, Madrid, Spain.
    Objective: Patients in PICUs frequently present hypochloremic metabolic alkalosis secondary to loop diuretic treatment, especially those undergoing cardiac surgery. This study evaluates the effectiveness of acetazolamide therapy for metabolic alkalosis in PICU patients.

    Design: Retrospective, observational study. Read More

    A novel variant in the SLC12A1 gene in two families with antenatal Bartter syndrome.
    Acta Paediatr 2017 Jan;106(1):161-167
    Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.
    Aim: Bartter syndrome is an autosomal-recessive inherited disease in which patients present with hypokalaemia and metabolic alkalosis. We present two apparently nonrelated cases with antenatal Bartter syndrome type I, due to a novel variant in the SLC12A1 gene encoding the bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 in the thick ascending limb of the loop of Henle.

    Methods: Blood samples were received from the two cases and 19 of their relatives, and deoxyribonucleic acid was extracted. Read More

    Gitelman-like Syndrome with Kanamycin Toxicity.
    J Assoc Physicians India 2016 May;64(5):90-92
    Postgraduate Trainee, Dept. of Medicine, Medical College, Kolkata, West Bengal.
    A 22 year-old lady with multi-drug-resistant pulmonary tuberculosis was on Kanamycin, Cycloserine, Ethionamide, Pyrazinamide and Moxifloxacin since more than two months. She presented with muscle cramps and carpopedal spasm. Investigation revealed hypokalemia and metabolic alkalosis. Read More

    Neonatal Bartter syndrome with cholelithiasis and hydrocephalus: Rare association.
    Pediatr Int 2016 Sep;58(9):912-5
    Department of Pediatrics, Division of Neonatology, Pamukkale University Faculty of Medicine, Denizli, Turkey.
    Neonatal Bartter syndrome (NBS) is a rare autosomal recessive renal tubular disorder. This disease is characterized by hypokalemia, hypochloremia, and metabolic alkalosis that is often associated with failure to thrive and recurrent episodes of dehydration. The combination of BS and cholelithiasis in an infant is very rare. Read More

    Analysis of Arterial Blood Gas Report in Chronic Kidney Diseases - Comparison between Bedside and Multistep Systematic Method.
    J Clin Diagn Res 2016 Aug 1;10(8):BC01-5. Epub 2016 Aug 1.
    Medical Officer in Charge-Government Blood Bank, Chandannagar SD Hospital , Government of West Bengal, India .
    Introduction: Acid Base Disorders (ABDs) are commonly encountered in critically ill Chronic Kidney Disease (CKD) patients. Timely and correct analysis of Arterial Blood Gases (ABG) is critical for the diagnosis, treatment and prediction of outcome of the patients.

    Aim: The aim was to explore type and prevalence of ABDs in 31 critically ill CKD patients from a tertiary care hospital in Maharashtra, to compare two methods of analysis- bedside and systematic approaches and to clinically correlate the nature of ABDs in these patients. Read More

    Congenital Chloride Diarrhea: Diagnosis by Easy-Accessible Chloride Measurement in Feces.
    Case Rep Pediatr 2016 22;2016:2519498. Epub 2016 Aug 22.
    Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
    Background. Congenital chloride diarrhea (CCD) is an autosomal recessive disorder caused by mutations in the genes encoding the intestinal Cl(-)/HCO3 (-) exchanger and is clinically characterized by watery, profound diarrhea, electrolyte disturbances, and metabolic alkalosis. The CCD diagnosis is based on the clinical symptoms and measurement of high chloride concentration in feces (>90 mmol/L) and is confirmed by DNA testing. Read More

    Acquired Bartter-Like Phenotype.
    J Assoc Physicians India 2015 Sep;63(9):78-9
    Post Graduate, Department of General Medicine, Vijayanagar Institute of Medical Sciences, Bellary, Karnataka.
    We present a case of middle-aged man who presented with sudden onset of weakness of both upper and lower limbs with hypotension and polyuria without any antecedent illness. Investigations showed severe hypokalemia, hypocalcemia, hyponatremia, mild hypomagnesemia, hypercalciuria, metabolic alkalosis and increased renin and aldosterone levels in the blood suggesting Bartter syndrome. Thus a diagnosis of acquired Bartter-like phenotype was made. Read More

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