Search our Database of Scientific Publications and Authors

I’m looking for a

    48027 results match your criteria Metabolic Acidosis

    1 OF 961

    Relationship between pH of ruminal fluid during subacute ruminal acidosis and physiological response of the Polish Holstein-Friesian dairy cows.
    Pol J Vet Sci 2017 Sep;20(3):551-558
    The aim of the study was to investigate the effect of ruminal fluid pH depression on biochemical indices of blood, urine, feces, and milk, and to determine which of them may be helpful as a marker for the diagnosis of subacute ruminal acidosis (SARA). Ruminal fluid samples were obtained by rumenocentesis from 305 cows representing 13 commercial dairy herds. The herds were selected based on percentages of cows with an assigned value of ruminal fluid pH segregated into three groups as: SARA-positive herd, if at least 25% of the ruminal fluid samples indicated a pH < 5. Read More

    Retrospective evaluation of the prognostic utility of plasma lactate concentration, base deficit, pH, and anion gap in canine and feline emergency patients.
    J Vet Emerg Crit Care (San Antonio) 2017 Nov 22. Epub 2017 Nov 22.
    Departments of Veterinary Surgical and Radiological Sciences, School of Veterinary Medicine, University of California at Davis, Davis, CA 95616.
    Objective: To determine the association of plasma lactate concentration, pH, base deficit (BD), and anion gap (AG) in dogs and cats on presentation to an emergency room with outcome, and to compare the prognostic significance of hyperlactatemia with a concurrent metabolic acidosis with that of hyperlactatemia and a normal metabolic acid-base balance.

    Design: Retrospective study.

    Setting: University teaching hospital. Read More

    The use of crystalloids in traumatic brain injury.
    Anaesthesiol Intensive Ther 2017 Nov 22. Epub 2017 Nov 22.
    Department of Anaesthesiology and Intensive Care, Medical University of Lublin, Poland.
    Fluid therapy is one of the most important treatments in patients with traumatic brain injury (TBI) as both hypo- and hypervolaemia can cause harm. The main goals of fluid therapy for patients with TBI are to optimize cerebral perfusion and to maintain adequate cerebral oxygenation. The avoidance of cerebral oedema is clearly essential. Read More

    Hypokalemia: A potentially life-threatening complication of tenofovir therapy.
    SAGE Open Med Case Rep 2017 14;5:2050313X17741010. Epub 2017 Nov 14.
    Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, FL, USA.
    Tenofovir is a nucleotide analog reverse transcriptase inhibitor approved for the treatment of HIV and hepatitis B infections. It is widely prescribed and an integral part of the recommended regimens for the treatment of HIV infection in antiretroviral-naive patients. Tenofovir is implicated in renal proximal tubular dysfunction, which can be associated with Fanconi syndrome and hypokalemia. Read More

    Oxygen and Glucose Deprivation Induces Bergmann Glia Membrane Depolarization and Ca(2+) Rises Mainly Mediated by K(+) and ATP Increases in the Extracellular Space.
    Front Cell Neurosci 2017 3;11:349. Epub 2017 Nov 3.
    Pharmacology and Biochemistry of the Synapse, Institut des Neurosciences Paris-Saclay, Université Paris-Saclay, Université Paris-Sud, CNRS, UMR 9197, Orsay, France.
    During brain ischemia, intense energy deficiency induces a complex succession of events including pump failure, acidosis and exacerbated glutamate release. In the cerebellum, glutamate is the principal mediator of Purkinje neuron anoxic depolarization during episodes of oxygen and glucose deprivation (OGD). Here, the impact of OGD is studied in Bergmann glia, specialized astrocytes closely associated to Purkinje neurons. Read More

    The prehospital management of hypothermia - An up-to-date overview.
    Injury 2017 Nov 4. Epub 2017 Nov 4.
    Traumasurgeon, Department of Surgery and Head of the Department of Emergency Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
    Background: Accidental hypothermia concerns a body core temperature of less than 35°C without a primary defect in the thermoregulatory system. It is a serious threat to prehospital patients and especially injured patients, since it can induce a vicious cycle of the synergistic effects of hypothermia, acidosis and coagulopathy; referred to as the trauma triad of death. To prevent or manage deterioration of a cold patient, treatment of hypothermia should ideally begin prehospital. Read More

    Thoracoscopic repair of congenital diaphragmatic hernia, review of the results.
    Minerva Pediatr 2017 Nov 21. Epub 2017 Nov 21.
    Department of Pediatric Surgery, Hospital de Braga, Braga, Portugal.
    Congenital diaphragmatic hernia (CDH) remains one of the major challenges in neonatal surgery. Survival rate has increased in the last decades mainly due to perinatal care and surgical technique improvements. Classically, a laparotomy has been performed after cardiovascular and respiratory stabilization. Read More

    G2A as a Threshold Regulator of Inflammatory Hyperalgesia Modulates Chronic Hyperalgesia.
    J Mol Neurosci 2017 Nov 21. Epub 2017 Nov 21.
    Department of Life Sciences, National Central University, Zhongda Road 300, Zhongli, Taoyuan City, Taiwan, 32054.
    Tissue injury, pathogen infection, and diseases are often accompanied by inflammation to release mediators that sensitize nociceptors and further recruit immune cells, which can lead to chronic hyperalgesia and inflammation. Tissue acidosis, occurring at the inflammatory site, is a major factor contributing to pain and hyperalgesia. The receptor G2 accumulation (G2A), expressed in neurons and immune cells, responds to protons or oxidized free fatty acids such as 9-hydroxyoctadecadienoic acid produced by injured cells or oxidative stresses. Read More

    A Mitochondrial Disorder in a Middle Age Iranian Patient: Report of a Rare Case.
    Basic Clin Neurosci 2017 Jul-Aug;8(4):337-341
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
    Introduction: Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) can involve multiple systems and cause stroke-like episodes and status epilepticus.

    Case Presentation: A 48-year-old female with history of early fatigability, migraine-type headaches, and bilateral sensory-neural hearing loss presented 3 episodes of serial seizures. On admission she was affected by Wernicke aphasia and, then, right hemiparesis. Read More

    Functional role of extracellular vesicles and lipoproteins in the tumour microenvironment.
    Philos Trans R Soc Lond B Biol Sci 2018 Jan;373(1737)
    Department of Clinical Sciences, Section of Oncology and Pathology, Lund University, Lund, Sweden
    Cancer can be regarded as an invasive organ that exhibits unique plasticity provided by coordinated, cancer cell-stromal cell communication in the tumour microenvironment. Typical stress factors in the tumour niche, such as hypoxia and acidosis, are major drivers and modulators of these events. Recent findings reveal an important role of extracellular vesicles and lipoproteins in cancer cell adaption to exogenous stress. Read More

    Euglycemic Diabetic Ketoacidosis Secondary to Dapagliflozin Use: a Case Report.
    J Emerg Med 2017 Nov 17. Epub 2017 Nov 17.
    Department of Emergency Medicine, University of Manitoba, Max Rady College of Medicine, Winnipeg, Manitoba, Canada.
    Background: Sodium-glucose co-transporter-2 (SGLT2) inhibitors are a novel class of oral antihyperglycemic agents. They are associated with rare cases of euglycemic diabetic ketoacidosis (DKA), which presents a diagnostic challenge in the emergency department (ED) and potentially severe consequences if missed.

    Case Report: A 53-year-old man with type 2 diabetes mellitus and a recent Roux-en-Y gastric bypass surgery presented to the ED with nausea, vomiting, and generalized abdominal pain. Read More

    [Acetaminophen induced 5-oxoproline acidosis: An uncommon case of high anion gap metabolic acidosis].
    Rev Med Interne 2017 Nov 17. Epub 2017 Nov 17.
    Néphrologie, CUMR, CHU de Caen, 14033 Caen cedex 9, France; Normandie université, Unicaen, UFR de médecine, 2, rue des Rochambelles, 14033 Caen cedex 9, France.
    The most common causes of high anion gap metabolic acidosis (HAGMA) are lactic acidosis, ketoacidosis, and intoxications. Nevertheless, clinicians can be faced with unexplained HAGMA, with a need to look for less common etiologies. We describe a case of 5-oxoproline (pyroglutamate) acidosis due to chronic acetaminophen ingestion at therapeutic dose in a 79-year-old inpatient. Read More

    Insulin resistance in chronic kidney disease.
    Nephrology (Carlton) 2017 Dec;22 Suppl 4:31-34
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    This review provides an overview of insulin resistance (IR) in patients with chronic kidney disease (CKD). IR is a pathological state in which target tissues fail to respond normally to insulin. IR is understood as a consequence of CKD and its prevalence rises particularly in advanced CKD stages. Read More

    Invited review: Practical feeding management recommendations to mitigate the risk of subacute ruminal acidosis in dairy cattle.
    J Dairy Sci 2017 Nov 15. Epub 2017 Nov 15.
    Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, Austria. Electronic address:
    Rumen health is of vital importance in ensuring healthy and efficient dairy cattle production. Current feeding programs for cattle recommend concentrate-rich diets to meet the high nutritional needs of cows during lactation and enhance cost-efficiency. These diets, however, can impair rumen health. Read More

    Subacute ruminal acidosis affects fermentation and endotoxin concentration in the rumen and relative expression of the CD14/TLR4/MD2 genes involved in lipopolysaccharide systemic immune response in dairy cows.
    J Dairy Sci 2017 Nov 15. Epub 2017 Nov 15.
    Department of Animal Nutrition and Feed Management, Poznań University of Life Science, 35 Wołyńska Street, 60-637 Poznań, Poland.
    The first objective of this study was to investigate the effects of subacute ruminal acidosis (SARA) on fermentation, ruminal free lipopolysaccharides (LPS), and expression of the cluster of differentiation 14 (CD14), toll-like receptor 4 (TLR4), and myeloid differentiation protein 2 (MD2) complex in white blood cells involved in the systemic immune response in dairy cows. The second objective was a study of whether increased expression of the LPS receptor complex led to increases in the concentrations of plasma high-density lipoprotein (HDL) and serum Ca. Three hundred five dairy cows located in 13 Polish high-yielding dairy commercial farms were selected according to their days in milk (40-150 d; average = 75), 305-d milk yield (10,070-12,041 kg; average = 10,940), and number of lactations (primiparous, n = 139 and multiparous, n = 166). Read More

    Determinants and Outcome of Metabolic Acidosis in Diarrheal Children Under 5 Years of Age in an Urban Critical Care Ward in Bangladesh.
    Glob Pediatr Health 2017 7;4:2333794X17740223. Epub 2017 Nov 7.
    International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
    We evaluated the independent determinants and outcome of metabolic acidosis in diarrheal children. Children under 5 years of age admitted with diarrhea and severe respiratory distress in the critical care ward at Dhaka Hospital of icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh) from April 2010 to April 2014 who had their reports of arterial blood gas analyses were enrolled in the study. We compared clinical and laboratory characteristics between the study children with (cases = 74) and without metabolic acidosis (controls = 65). Read More

    [Bicarbonate: From physiology to treatment for all clinicians].
    Nephrol Ther 2017 Nov 14. Epub 2017 Nov 14.
    Club des jeunes néphrologues, 2, rue du Bourg-l'Abbé, 75003 Paris, France; Explorations fonctionnelles rénales et métaboliques, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex, France; Faculté de médecine, université Paris Descartes, 75006 Paris, France. Electronic address:
    Acid-base regulation is essential to maintain homeostasis in humans. Carbonic acid/bicarbonate (H2CO3/HCO3(-)) couple is the most predominant extracellular buffer to keep plasma pH within a physiological range. The ability to (re)generate such a buffer is a key milestone that necessitates to understand a precise physiology of both renal tubule and digestive tract. Read More

    Tumor Acidosis and Hypoxia Differently Modulate the Inflammatory Program: Measurements In Vitro and In Vivo.
    Neoplasia 2017 Nov 14;19(12):1033-1042. Epub 2017 Nov 14.
    Julius Bernstein Institute of Physiology, University Halle-Wittenberg, Germany.
    Inflammatory mediators produced by the tumor cells are of importance for immune response but also for malignant progression. The aim of the study was to analyze the expression of monocyte chemoattractant protein-1, interleukin-6 (IL-6), tumor necrosis factor-α, inducible isoform of nitric oxide synthase (iNOS), cyclooxygenase-2, and osteopontin in vitro in two different tumor cell lines under hypoxia (pO2≈1.5 mmHg) and/or acidosis (pH=6. Read More

    Incidence and Consequences of Near-Drowning-Related Pneumonia-A Descriptive Series from Martinique, French West Indies.
    Int J Environ Res Public Health 2017 Nov 17;14(11). Epub 2017 Nov 17.
    Intensive Care Unit, University Hospital of Martinique, Fort-de-France, 97261 Martinique, France.
    Drowning represents one major cause of accidental death. Near-drowning patients are exposed to aspiration that may result in pneumonia with life-threatening consequences. We designed this descriptive study to investigate the frequency, nature, and consequences of post-drowning pneumonia. Read More

    Single-centre experience with the Impella CP, 5.0 and RP in 109 consecutive patients with profound cardiogenic shock.
    Eur Heart J Acute Cardiovasc Care 2017 Nov 1:2048872617743194. Epub 2017 Nov 1.
    1 Department of Cardiology, Cardio-Thoracic surgery and Anesthesiology, Odense University Hospital, Denmark.
    Rationale: Short-term mechanical circulatory support is increasingly used in the management of cardiogenic shock, but data from controlled studies are sparse. Thus, real-life data on complication rates and predictors of adverse outcome are important.

    Objective: The objective of this study was to analyse the experience with Impella devices in the management of profound cardiogenic shock. Read More

    Association between Urine Ammonium and Urine TGF-β1 in CKD.
    Clin J Am Soc Nephrol 2017 Nov 16. Epub 2017 Nov 16.
    Department of Internal Medicine, University of Utah Health, Salt Lake City, Utah.
    Background And Objectives: Urinary ammonium excretion increases in response to nonvolatile acids to maintain normal systemic bicarbonate and pH. However, enhanced ammonia production promotes tubulointerstitial fibrosis in animal models. Therefore, a subset of individuals with CKD and normal bicarbonate may have acid-mediated kidney fibrosis that might be better linked with ammonium excretion than bicarbonate. Read More

    Metabolic effects of Carbon Dioxide (CO2) insufflation during laparoscopic surgery: changes in pH, arterial partial Pressure of Carbon Dioxide (PaCo2) and End Tidal Carbon Dioxide (EtCO2).
    Cent Afr J Med 2015 Sep-Dec;61(9-12):61-5
    Background: Acid base alterations occur during laparoscopy with carbon dioxide insufflation. The purpose of this study was to investigate the effects of low tidal volume ventilation on acid base status during pneumoperitonium.

    Materials And Methods: 30 patients undergoing laparoscopic surgery under General Anaesthesia were ventilated with tidal volume of 6 ml/kg and respiratory rate of 12 breaths/minute. Read More

    Shifting Risks and Conflicting Outcomes-ECMO for Neonates with Congenital Diaphragmatic Hernia in the Modern Era.
    J Pediatr 2017 Nov;190:163-168.e4
    Department of Pediatrics, University of Washington, Seattle, WA.
    Objectives: To update previously described trends for neonates with congenital diaphragmatic hernia (CDH) receiving ECMO with changes in recommendations for care, and to determine how recent advancements in respiratory care have affected this patient population.

    Study Design: This study is a retrospective review of more than 2500 neonates with CDH who received ECMO listed in the Extracorporeal Life Support Organization (ELSO) registry. Cochran-Armitage and multivariate regression analyses were used to analyze changes in the patient population over time and in mortality-related risk factors. Read More

    Plasma-Lyte 148 vs. Hartmann's solution for cardiopulmonary bypass pump prime: a prospective double-blind randomized trial.
    Perfusion 2017 Nov 1:267659117742479. Epub 2017 Nov 1.
    5 Department of Intensive Care, The University of Melbourne, Victoria, Australia.
    Background: The mechanisms of acid-base changes during cardiopulmonary bypass (CPB) remain unclear. We tested the hypothesis that, when used as CPB pump prime solutions, Plasma-Lyte 148 (PL) and Hartmann's solution (HS) have differential mechanisms of action in their contribution to acid-base changes.

    Methods: We performed a prospective, double-blind, randomized trial in adult patients undergoing elective cardiac surgery with CPB. Read More

    ASIC2a overexpression enhances the protective effect of PcTx1 and APETx2 against acidosis-induced articular chondrocyte apoptosis and cytotoxicity.
    Gene 2017 Nov 13. Epub 2017 Nov 13.
    Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Anti-inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education, Hefei 230032, China. Electronic address:
    Acid hydrarthrosis is another important pathological character in rheumatoid arthritis (RA), and acid-sensing ion channel 1a (ASIC1a) plays a destructive role in acidosis-induced articular chondrocyte cytotoxicity. Recently, ASIC2a has been reported to possess neuroprotective effect on acidosis-induced injury of neuronal cells. However, whether ASIC2a has an enhanced effect on the protective effect of blocking ASIC1a and ASIC3 against acid-induced chondrocyte apoptosis is still unclear. Read More

    Hypertonic saline resuscitation following emergent laparotomy and temporary abdominal closure.
    J Trauma Acute Care Surg 2017 Nov 14. Epub 2017 Nov 14.
    From the University of Florida Health, Department of Surgery and Sepsis and Critical Illness Research Center in Gainesville, Florida.
    Background: Our objective was to establish the safety of 3% hypertonic saline (HTS) resuscitation for trauma and acute care surgery patients undergoing emergent laparotomy and temporary abdominal closure (TAC) with the hypothesis that HTS administration would be associated with hyperosmolar hypercholoremic acidosis, lower resuscitation volumes, and higher fascial closure rates, without adversely affecting renal function.

    Methods: We performed a retrospective cohort analysis of 189 trauma and acute care surgery patients who underwent emergent laparotomy and TAC, comparing patients with normal baseline renal function who received 3% HTS at 30 mL/h (n=36) to patients with standard resuscitation (n=153) by baseline characteristics, resuscitation parameters, and outcomes including primary fascial closure and KDIGO stages of acute kidney injury.

    Results: HTS and standard resuscitation groups had similar baseline illness severity and organ dysfunction, though HTS patients had lower serum creatinine at initial laparotomy (1. Read More

    TALEN-mediated shift of mitochondrial DNA heteroplasmy in MELAS-iPSCs with m.13513G>A mutation.
    Sci Rep 2017 Nov 14;7(1):15557. Epub 2017 Nov 14.
    Department of Anatomy I, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
    Induced pluripotent stem cells (iPSCs) are suitable for studying mitochondrial diseases caused by mitochondrial DNA (mtDNA) mutations. Here, we generated iPSCs from a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) with the m.13513G>A mutation. Read More

    In silico identification of genes involved in chronic metabolic acidosis.
    Life Sci 2017 Nov 11. Epub 2017 Nov 11.
    King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
    Aims: Chronic metabolic acidosis (CMA) refers to increased plasma acidity due to disturbed acid-base equilibrium in human body. CMA leads to many dysfunctions including disorders of intestinal metabolism and barrier functions. The human body responds to these intestinal dysfunctions by creating a compensatory mechanism at genomic level in intestinal epithelial cells. Read More

    Hyperammonemia associated with distal renal tubular acidosis or urinary tract infection: a systematic review.
    Pediatr Nephrol 2017 Nov 13. Epub 2017 Nov 13.
    Department of Internal Medicine, Ente Ospedaliero Cantonale, Mendrisio, Switzerland.
    Background: Hyperammonemia usually results from an inborn error of metabolism or from an advanced liver disease. Individual case reports suggest that both distal renal tubular acidosis and urinary tract infection may also result in hyperammonemia.

    Methods: A systematic review of the literature on hyperammonemia secondary to distal renal tubular acidosis and urinary tract infection was conducted. Read More

    Intensive care in severe malaria: Report from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine.
    J Crit Care 2017 Nov 8. Epub 2017 Nov 8.
    Department of Critical Care Medicine, Bombay Hospital Institute of Medical Sciences, Mumbai, India. Electronic address:
    Severe malaria is common in tropical countries in Africa, Asia, Oceania and South and Central America. It may also occur in travelers returning from endemic areas. Plasmodium falciparum accounts for most cases, although P vivax is increasingly found to cause severe malaria in Asia. Read More

    In vivo molecular EPR-based spectroscopy and imaging of tumor microenvironment and redox using functional paramagnetic probes.
    Antioxid Redox Signal 2017 Nov 13. Epub 2017 Nov 13.
    West Virginia University Health Sciences Center, 53422, Biochemistry , 1 Medical Center Drive P.O. Box 9142 , Morgantown, West Virginia, United States , 26506 ;
    Significance: A key role of the tumor microenvironment (TME) in cancer progression, treatment resistance and as a target for therapeutic intervention is increasingly appreciated. Among physiological components of the TME are tissue hypoxia, acidosis, high reducing capacity, elevated concentrations of intracellular glutathione (GSH) and interstitial inorganic phosphate (Pi). Noninvasive in vivo assessment of these parameters provide unique insights into biological processes in TME, and may serve as a tool for pre-clinical screening of anticancer drugs and optimizing TME-targeted therapeutic strategies. Read More

    Spurious Hyperchloremia in the Presence of Elevated Plasma Salicylate: A Cohort Study.
    Nephron 2017 Nov 9. Epub 2017 Nov 9.
    Division of Nephrology and Hypertension, Rochester, Minnesota, USA.
    Background: Acute metabolic acidosis is rarely associated with a reduced or negative anion gap (AG), but several case reports have described such an abnormality occurring in the setting of acute salicylate intoxication. The underlying cause of this phenomenon is unclear.

    Methods: In this retrospective cohort study, we reviewed our institutional database to identify all patients admitted for salicylate intoxication at Mayo Clinic (Rochester, MN, USA) from January 2010 through December 2012. Read More

    The effects of feeding a partial mixed ration plus a top-dress before feeding on milk production and the daily rhythm of feed intake and plasma hormones and metabolites in dairy cows.
    J Dairy Sci 2017 Nov 8. Epub 2017 Nov 8.
    Department of Animal Science, Penn State University, University Park 16802. Electronic address:
    Total mixed rations (TMR) are commonly fed to dairy cows with a goal of reducing ruminal acidosis, but the daily pattern of feed intake has major implication for rumen fermentation and postabsorptive physiology. Generally there is low feed intake during the overnight period and high intake after feeding and during the afternoon. The objective of this study was to determine if feeding a partial mixed ration (PMR) plus a high starch top-dress before feeding of the PMR would improve production and modify key daily rhythms. Read More

    Diabetic ketoacidosis, hyperuricemia, and encephalopathy intractable to regular-dose insulin.
    J Pediatr Endocrinol Metab 2017 Nov 11. Epub 2017 Nov 11.
    Background: Diabetic ketoacidosis (DKA) in children less than 1 year of age is a rare occurrence. Typical presentation includes a prodrome of weight loss and polyuria with subsequent presentation to medical care when acidosis becomes symptomatic.

    Case Presentation: We describe an unusual case of a previously healthy infant with a 3 days' history of constipation, presenting acutely with abdominal pain, lethargy, and dehydration. Read More

    High aldosterone and cortisol levels in salt wasting congenital adrenal hyperplasia: a clinical conundrum.
    J Pediatr Endocrinol Metab 2017 Nov 11. Epub 2017 Nov 11.
    Background: Salt wasting syndrome (hyponatremia, hyperkalemia, dehydration, metabolic acidosis) in early infancy could be caused by either mineralocorticoid deficiency as in congenital adrenal hyperplasia (CAH) and adrenal insufficiency or mineralocorticoid resistance as in pseudohypoaldosteronism (PHA). In salt wasting CAH, serum aldosterone and cortisol levels are expected to be low. Cross reactivity between high levels of adrenal steroid precursors and aldosterone has recently been reported resulting in elevated aldosterone levels in CAH, leading to difficulty in differentiating between CAH and PHA. Read More

    Dimer formation of GdDO3A-arylsulfonamide complexes causes loss of pH-dependency of relaxivity.
    Dalton Trans 2017 Nov 10. Epub 2017 Nov 10.
    Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, Walther-Meißner-Strasse 3, D-85748 Garching, Germany.
    Gadolinium(iii) complexes with pH-dependent relaxivities have been proposed as responsive magnetic resonance imaging (MRI) contrast agents (CA) for mapping of pH value in living subjects. The latter is clinically relevant because hypoxia-induced reduction of interstitial pH (acidosis) is a hallmark of tumor progression and resistance against chemotherapy. In order to obtain versatile building blocks for integration of a pH-responsive MRI-CA functionality into larger molecular assemblies, such as bioconjugates, micelles or nanoparticles, we equipped the structural motif GdDO3A-ethylene(arylsulfonic acid) with additional carboxylic acid moieties in the aromatic para-position. Read More

    [Metformin-associated lactic acidosis: an insufficiently recognised problem].
    Ned Tijdschr Geneeskd 2017 ;161(0):D1823
    Rijnstate Arnhem, Arnhem.
    Metformin-associated lactic acidosis (MALA) is a rare but potentially fatal condition that can easily be avoided. As metformin is known to facilitate the production of lactate, predisposing factors can accelerate this process. In situations of infection or dehydration, metformin can accumulate due to kidney failure, hereby increasing the risk of MALA. Read More

    The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of native FMRFamide peptide.
    J Biol Chem 2017 Nov 9. Epub 2017 Nov 9.
    Shanghai Jiao Tong University School of Medicine, China;
    The degenerin/epithelial sodium channel (DEG/ENaC) superfamily of ion channels contains subfamilies with diverse functions that are fundamental to many physiological and pathological processes, ranging from synaptic transmission to epileptogenesis. The absence in mammals of some DEG/ENaCs subfamily orthologs such as FMRFamide peptide-activated sodium channels (FaNaCs), which have been identified only in mollusks, indicates that the various subfamilies diverged early in evolution. We recently reported that the nonproton agonist 2-guanidine-4-methylquinazoline (GMQ) activates acid-sensing ion channels (ASICs), a DEG/ENaC subfamily mainly in mammals, in the absence of acidosis. Read More

    Effects of intraoperative and early postoperative normal saline or Plasma-Lyte 148® on hyperkalaemia in deceased donor renal transplantation: a double-blind randomized trial.
    Br J Anaesth 2017 Oct;119(4):606-615
    Department of Nephrology, Austin Hospital, Victoria, Australia.
    Background: Administration of saline in renal transplantation is associated with hyperchloraemic metabolic acidosis, but the effect of normal saline (NS) on the risk of hyperkalaemia or postoperative graft function is uncertain.

    Methods: We compared NS with Plasma-Lyte 148® (PL) given during surgery and for 48 h after surgery in patients undergoing deceased donor renal transplantation. The primary outcome was hyperkalaemia within 48 h after surgery. Read More

    Thiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient.
    Case Rep Crit Care 2017 8;2017:5121032. Epub 2017 Oct 8.
    Section of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
    Thiamine plays a critical role in energy metabolism. Critically ill children and adults may develop thiamine deficiency with ultimately increased mortality due to potentially irreversible consequences of severe type B lactic acidosis. We report a case of an unvaccinated term neonate with malignant pertussis requiring extracorporeal membrane oxygenation and continuous renal replacement therapy, who developed profound lactic acidosis of unknown etiology. Read More

    One-Year Conservative Care Using Sodium Bicarbonate Supplementation Is Associated with a Decrease in Electronegative LDL in Chronic Kidney Disease Patients: A Pilot Study.
    Cardiorenal Med 2017 Oct 17;7(4):334-341. Epub 2017 Aug 17.
    Division of Nephrology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
    Background: Chronic kidney disease (CKD) patients develop metabolic acidosis when approaching stages 3 and 4, a period in which accelerated atherogenesis may ensue. Studies in vitro show that low pH may increase low-density lipoprotein (LDL) oxidation, suggesting a role for chronic metabolic acidosis in atherosclerosis. The present study attempted to evaluate the effects of conservative care using oral sodium bicarbonate (NaHCO3) supplementation on the electronegative LDL [LDL(-)], a minimally oxidized LDL, plasma levels in CKD patients. Read More

    Safety of Metformin Therapy in Patients with Type 2 Diabetes Living on an Oxygen-Deficient Plateau, Tibet, China.
    Exp Clin Endocrinol Diabetes 2017 Nov 8. Epub 2017 Nov 8.
    Department of Endocrinology and Metabolism, People's Hospital of Tibet Autonomous Region, Tibet, P. R. China.
    Background In the general population, the absolute risk of lactic acidosis in patients treated with metformin appears to be low. However, in the Tibetan plateau, an extreme oxygen-deficient environment, there are no data available concerning the safety of metformin. The aim of our study is to assess the safety of metformin in people of the plateau area. Read More

    Fanconi syndrome and neonatal diabetes: phenotypic heterogeneity in patients with GLUT2 defects.
    CEN Case Rep 2017 Nov 8. Epub 2017 Nov 8.
    Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
    Fanconi-Bickel syndrome, caused by mutations in SLC2A2 encoding the glucose transporter 2 (GLUT2), is characterized by generalized proximal renal tubular dysfunction manifesting in late infancy. We describe phenotypic heterogeneity of Fanconi-Bickel syndrome in three siblings, including early and atypical presentation with transient neonatal diabetes mellitus in one. The second-born of a non-consanguineous couple, evaluated for polyuria and growth retardation, had rickets, hepatomegaly and proximal tubular dysfunction from 4 to 6  months of age. Read More

    Cancer Metabolism and Tumor Heterogeneity: Imaging Perspectives Using MR Imaging and Spectroscopy.
    Contrast Media Mol Imaging 2017 9;2017:6053879. Epub 2017 Oct 9.
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
    Cancer cells reprogram their metabolism to maintain viability via genetic mutations and epigenetic alterations, expressing overall dynamic heterogeneity. The complex relaxation mechanisms of nuclear spins provide unique and convertible tissue contrasts, making magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) pertinent imaging tools in both clinics and research. In this review, we summarized MR methods that visualize tumor characteristics and its metabolic phenotypes on an anatomical, microvascular, microstructural, microenvironmental, and metabolomics scale. Read More

    Therapeutic Effects of Curcumin on Ultrasonic Morphological Characteristics of Liver in Patients with Metabolic Syndrome.
    Acta Inform Med 2017 Sep;25(3):169-174
    Primary Health Care Center Tuzla, Tuzla, Bosnia and Herzegovina.
    Introduction: Metabolic syndrome (METS) represent a simultaneous presence of multiple metabolic disorders in one person. Prevalence is increasing worldwide, which is probably related to increased obesity and sedentary lifestyle. Non-alcoholic steatosis or "fatty liver" is a metabolic disease caused by fat dysfunction. Read More

    Acidic stress induces apoptosis and inhibits angiogenesis in human bone marrow-derived endothelial progenitor cells.
    Oncol Lett 2017 Nov 15;14(5):5695-5702. Epub 2017 Sep 15.
    Department of Pharmacy, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510080, P.R. China.
    Bone marrow-derived endothelial progenitor cells (BM-EPCs) are exposed to acidotic environments in a variety of physiological and pathological conditions, including in tumors. However, the effect of acidosis on the function of BM-EPCs is still not fully understood. In the present study, BM-EPCs were isolated and cultured at an extracellular pH (pHe) of 6. Read More

    Cardiogenic Shock Due to End-Stage Heart Failure and Acute Myocardial Infarction: Characteristics and Outcome of Temporary Mechanical Circulatory Support.
    Shock 2017 Nov 3. Epub 2017 Nov 3.
    University Hospital Birmingham, Edgbaston, Birmingham B15 2TH, UK.
    Background: Mechanical circulatory support (MCS) is increasingly used in cardiogenic shock, but outcomes may differ between patients with acute myocardial infarction (AMI) or end-stage heart failure (ESHF). This study aimed to describe the characteristics of patients with cardiogenic shock due to AMI and ESHF.

    Methods: Single centre study of consecutive patients with cardiogenic shock due to AMI (n = 26) and ESHF (n = 42) who underwent MCS (extracorporeal life support, Impella or temporary ventricular assist devices). Read More

    Potential Visualization of Sorafenib-Induced Acidosis Using 11C-Acetate PET/CT in Patients With Hepatocellular Carcinoma.
    Clin Nucl Med 2017 Nov 3. Epub 2017 Nov 3.
    From the Departments of *Nuclear Medicine and †Oncology, Chonnam National University Hwasun Hospital, Jeonnam, Republic of Korea.
    C-acetate uptake could be increased in physiologic or inflammatory conditions without evidence of cancer. We report a hepatocellular carcinoma patient with sorafenib-induced metabolic acidosis, who showed increased hepatic uptake of C-acetate. C-acetate PET/CT might be a potentially useful surrogate marker to monitor these adverse effects via the changes in C-acetate uptake patterns from before to after drug withdrawal. Read More

    Impact of continuation of metformin prior to elective coronary angiography on acute contrast nephropathy in patients with normal or mildly impaired renal functions.
    Anatol J Cardiol 2017 10 31. Epub 2017 Oct 31.
    Department of Cardiology, Institute of Cardiology, İstanbul University; İstanbul-Turkey.
    Objective: Discontinuation of metformin treatment in patients scheduled for elective coronary angiography (CAG) is controversial because of post-procedural risks including acute contrast-induced nephropathy (CIN) and lactic acidosis (LA). This study aims to discuss the safety of continuing metformin treatment in patients undergoing elective CAG with normal or mildly impaired renal functions.

    Methods: Our study was designed as a single-centered, randomized, and observational study including 268 patients undergoing elective CAG with an estimated glomerular filtration rate of >60 mL/min/1. Read More

    1 OF 961