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    1 OF 940

    Effects of vasoactive drugs on crystalloid fluid kinetics in septic sheep.
    PLoS One 2017 23;12(2):e0172361. Epub 2017 Feb 23.
    Research Unit, Södertälje Hospital, Södertälje, Sweden.
    Purpose: Crystalloid fluid and vasoactive drugs are used in the early treatment of sepsis. The purpose of the present study was to examine how these drugs alter plasma volume expansion, peripheral edema, and urinary excretion.

    Methods: Twenty-five anesthetized sheep were made septic by cecal puncture and a short infusion of lipopolysaccharide. Read More

    Immediately Functioning Grafts from Brain-Dead Donors Treated with Extracorporeal Membrane Oxygenation.
    Exp Clin Transplant 2017 Feb 23. Epub 2017 Feb 23.
    From the Saudi Center for Organ Transplantation, Riyadh, Saudi Arabia.
    A brain-dead donor experienced repeated cardiac arrests followed by severe hypotension requiring multiple vasoactive agents. These events were associated with severe lactic acidosis and dysregulated kidney function in the donor. A 10-hour treatment with extracorporeal membranous oxygenation was instituted, which was able to hemodynamically stabilize the donor. Read More

    Recurrent Alternate-Sided Homonymous Hemianopia Due to Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-Like Episodes (MELAS): A Case Report.
    Neuroophthalmology 2017 Feb 23;41(1):30-34. Epub 2016 Sep 23.
    Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Department of Ophthalmology and Visual Sciences, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
    Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) can rarely cause alternate-sided homonymous hemianopia due to stroke-like episodes involving the occipital lobes, as reported in three previously published cases. The authors report an interesting case of a 16-year-old presenting with myoclonic epilepsy due to MELAS with the rare ND3 mitochondrial mutation T10191C, with recurrent alternate-sided homonymous hemianopia. Visual field and corresponding magnetic resonance imaging (MRI) findings are presented. Read More

    Malabsorption syndrome as a rare cause of nephrocalcinosis.
    Clin Cases Miner Bone Metab 2016 Sep-Dec;13(3):247-248. Epub 2017 Feb 10.
    Department of Nephrology, Centro Hospitalar Trás-os-Montes e Alto Douro, Vila Real, Portugal.
    Nephrocalcinosis is characterized by calcification of kidney parenchyma and can be caused by an increased amount of calcium, phosphate or oxalate in urinary excretion. We report a 35-year-old female with nephrocalcinosis. She had fitful steatorrhea since last year. Read More

    Shoshin beriberi-thiamine responsive pulmonary hypertension in exclusively breastfed infants: A study from northern India.
    Indian Heart J 2017 Jan - Feb;69(1):24-27. Epub 2016 Aug 2.
    Department of Pediatrics, SKIMS Srinagar, J&K, India. Electronic address:
    Objective: To study the effect of thiamine administration on the resolution of pulmonary hypertension in exclusively breastfed infants.

    Design: Prospective cohort study.

    Setting: Hospital based study of a tertiary care hospital. Read More

    Treatment of Metformin Intoxication Complicated by Lactic Acidosis and Acute Kidney Injury: The Role of Prolonged Intermittent Hemodialysis.
    Am J Kidney Dis 2017 Feb 17. Epub 2017 Feb 17.
    Acute and Chronic Renal Failure Unit, Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy.
    Metformin intoxication with lactic acidosis, a potentially lethal condition, may develop in diabetic patients when the drug dose is inappropriate and/or its clearance is reduced. Diagnosis and therapy may be delayed due to nonspecific symptoms at presentation, with severe anion gap metabolic acidosis and elevated serum creatinine values being the most prominent laboratory findings. Confirmation requires measurement of serum metformin by high-performance liquid chromatography-tandem mass spectrometry, but this technique is available only at specialized institutions and cannot be relied on as a guide to immediate treatment. Read More

    Arctic ground squirrel hippocampus tolerates oxygen glucose deprivation independent of hibernation season even when not hibernating and after ATP depletion, acidosis and glutamate efflux.
    J Neurochem 2017 Feb 21. Epub 2017 Feb 21.
    Department of Chemistry and Biochemistry, University of Alaska Fairbanks, Fairbanks, AK, USA.
    Cerebral ischemia/reperfusion (I/R) triggers a cascade of uncontrolled cellular processes that perturb cell homeostasis. The arctic ground squirrel (AGS), a seasonal hibernator resists brain damage following cerebral I/R caused by cardiac arrest and resuscitation. However, it remains unclear if tolerance to I/R injury in AGS depends on the hibernation season. Read More

    Three cases of Gordon syndrome with dominant KLHL3 mutations.
    J Pediatr Endocrinol Metab 2017 Feb 21. Epub 2017 Feb 21.
    Background: Gordon syndrome (GS) is a rare form of monogenic hypertension characterized by low renin hypertension, hyperkalemia, hyperchloremic metabolic acidosis, and normal glomerular filtration rate. To date, four genes causing GS have been identified as: WNK1, WNK4, CUL3, and KLHL3.

    Case Report: We report three cases of GS in two families. Read More

    Lymphoma and Lactic Acidosis.
    Clin Nucl Med 2017 Feb 17. Epub 2017 Feb 17.
    From the Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN.
    A 39-year-old man presented with new onset of sinus congestion, shortness of breath, and diaphoresis. His laboratory tests were notable for hypercalcemia and lactic acidosis. A CT scan of the head demonstrated mild paranasal disease. Read More

    [Etiopathogenic factors of the different types of urinary litiasis.]
    Arch Esp Urol 2017 Jan;70(1):40-50
    Unidad de Urolitiasis y Endourología. Servicio de Urología. Complejo Hospitalario Universitario Granada. España.
    In this review, we analyze the etiopathogenic principles of urinary lithiasis formation. In the kidney, calcifications that may cause renal lithiasis are produced as a consequence of processes that injury the urothelium at the papilla and Bellini's ducts. With the improvement of imaging techniques, mainly micro CT scan, it is possible to detect them and we may be able to anticipate to the formation of lithiasis. Read More

    [Urinary lithiasis as a systemic disease.]
    Arch Esp Urol 2017 Jan;70(1):28-39
    Unidad de Gestion Clinica de Urología. Hospital Universitario de Valme. Sevilla. España.
    Urinary lithiasis is a prevalent disorder of uncertain origin which provokes health problems through potential harm to the urinary system, renal parenchyma or the body as a whole, with a frequent trend to relapse. Historically urinary calculi have been studied and treated as an isolated disease but nowadays we know more about their connection with other pathological entities. In a small percentage of patients, diseases like primary hyperparathyroidism, tubular renal acidosis, inflammatory bowel disease or bariatric surgery have a fairly well studied physiopathological link with kidney stones. Read More

    Ion Transport by Ameloblasts during Amelogenesis.
    J Dent Res 2017 Mar 19;96(3):243-253. Epub 2016 Dec 19.
    1 Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, MOVE Research Institute, Amsterdam, Netherlands.
    Hypomineralization of developing enamel is associated with changes in ameloblast modulation during the maturation stage. Modulation (or pH cycling) involves the cyclic transformation of ruffle-ended (RE) ameloblasts facing slightly acidic enamel into smooth-ended (SE) ameloblasts near pH-neutral enamel. The mechanism of ameloblast modulation is not clear. Read More

    Long-Term Results Of Ileal Ureteric Replacement - A 25 Years Single Centre Experience.
    BJU Int 2017 Feb 20. Epub 2017 Feb 20.
    Department of Urology and Pediatric Urology, Julius-Maximilians-University Medical School, Oberdürrbacher Straße, 97080, Würzburg, Germany.
    Objectives: To report the long-term outcome of ileal ureteric replacement (IUR) in complex reconstruction of the urinary tract.

    Patients And Methods: From 1991 to 2016, IUR was performed in 157 patients with structural or functional ureteric loss. In 52 patients, bilateral IUR became necessary. Read More

    Vinculin variant M94I identified in sudden unexplained nocturnal death syndrome decreases cardiac sodium current.
    Sci Rep 2017 Feb 20;7:42953. Epub 2017 Feb 20.
    Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison, WI 53792, USA.
    Sudden unexplained nocturnal death syndrome (SUNDS) remains an autopsy negative disorder with unclear etiology. Vinculin (VCL) was linked to sudden arrhythmia death in VCL knockout mice prior to the appearance of cardiomyopathy. We hypothesized VCL mutations underlie risk for SUNDS. Read More

    Review: Systematic review of the utility of the fetal cerebroplacental ratio measured at term for the prediction of adverse perinatal outcome.
    Placenta 2017 Feb 12. Epub 2017 Feb 12.
    Mater Research Institute, University of Queensland, Brisbane, Australia; Mater Health Service, Brisbane, Australia; School of Medicine, University of Queensland, Brisbane, Australia. Electronic address:
    Aim: This systematic review evaluates the utility of the fetal cerebroplacental ratio (CPR) when assessed at term (from 37 + 0 weeks gestation) as a predictor of adverse obstetric and perinatal outcomes.

    Data Sources And Search Strategy: An electronic search of Pubmed and Embase using variations of 'cerebroplacental ratio' and 'cerebroumbilical ratio' was conducted by two independent reviewers. Full text studies written in English that reported on low CPR and its correlation with relevant obstetric and perinatal outcomes were included. Read More

    Effect of dietary roughage level on chewing activity, ruminal pH, and saliva secretion in lactating Holstein cows.
    J Dairy Sci 2017 Feb 16. Epub 2017 Feb 16.
    Ruminant Nutrition and Physiology Laboratory, College of Animal Science and Technology, Shandong Agricultural University, Taian 271018, P. R. China. Electronic address:
    Increasing dietary roughage level is a commonly used strategy to prevent subacute ruminal acidosis. We hypothesized that high-roughage diets could promote chewing activity, saliva secretion, and hence more alkaline to buffer rumen pH. To verify the hypothesis, 12 multiparous Holstein cows in mid-lactation were randomly allocated to 4 treatments in a triplicated 4 × 4 Latin square experiment with one cow in each treatment surgically fitted with a ruminal cannula. Read More

    Identification of the Causes for Chronic Hypokalemia: Importance of Urinary Sodium and Chloride Excretion.
    Am J Med 2017 Feb 14. Epub 2017 Feb 14.
    Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan. Electronic address:
    Background: Uncovering the correct diagnosis of chronic hypokalemia with potassium (K(+)) wasting from the kidneys or gut can be fraught with challenges. We identified clinical and laboratory parameters helpful for differentiating the causes of chronic hypokalemia.

    Methods: Normotensive patients referred to our tertiary academic medical center for the evaluation of chronic hypokalemia were prospectively enrolled over five years. Read More

    [Zinc phosphide poisoning in pediatric patients from a Toxicology Center at Mexico City].
    Rev Med Inst Mex Seguro Soc 2017 ;55 Suppl 1:S44-S52
    Departamento Clínico de Toxicología, Hospital General "Dr. Gaudencio González Garza", Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Ciudad de México, México.
    Background: Zinc phosphide is a chemical compound that is frequently used as a rodenticide; it is a highly toxic product that is widely used, among other spaces, at home. Given that it is a highly commercialized pesticide and that there is no antidote, it is mandatory to establish favorably the clinical manifestations of the intoxication. The aim was to describe the epidemiological and clinical profile of children intoxicated with zinc phosphide attended in a toxicological center of a tertiary referral hospital. Read More

    Acid-base disorders after orthotopic bladder replacement: comparison of an ileal neobladder and an ileal conduit.
    Ren Fail 2017 Nov;39(1):379-384
    a Division of Nephrology, Department of Internal Medicine.
    Objectives: For many years, creation of an orthotopic neobladder after cystectomy has been popular. In the present study, we measured the extent of metabolic acidosis in patients with ileal neobladders compared with ileal conduits and defined risk factors for development of metabolic acidosis.

    Methods: We retrospectively studied 95 patients, who underwent radical cystectomy and urinary diversion to treat invasive bladder cancer from January 2001 to December 2014 at Hallym University Kangnam Sacred Heart Hospital, through investigation of acid-base balance, serum electrolyte levels and renal function one month and one year after operation. Read More

    Role of Routine Subhepatic Abdominal Drain Placement following Uncomplicated Laparoscopic Cholecystectomy: A Prospective Randomised Study.
    J Clin Diagn Res 2016 Dec 1;10(12):PC03-PC05. Epub 2016 Dec 1.
    Professor, Department of Surgery, Govt Medical College and Rajindra Hospital , Patiala, Punjab, India .
    Introduction: Routine abdominal drainage after laparoscopy cholecystectomy is an issue of considerable debate. Reason for draining is to detect early bile/blood leak and allow CO2 insufflate during laparoscopy to escape via drain site thereby decreased shoulder tip pain and post-operative nausea and vomiting. But some studies show no difference in post-operative nausea /vomiting/pain between drain and no drain group. Read More

    Clinical study on amplitude integrated electroencephalogram in cerebral injury caused by severe neonatal hyperbilirubinemia.
    Minerva Pediatr 2017 Feb 15. Epub 2017 Feb 15.
    Department of Neonatology, Xuzhou Children's Hospital, Xuzhou, Jiangsu, China.
    Background: This study was designed in order to assess the validity of the use of amplitude-integrated electroencephalogram (aEEG) in cerebral injury caused by severe neonatal hyperbilirubinemia.

    Methods: A total of 56 full-term neonates diagnosed with severe neonatal hyperbilirubinemia and admitted to the NICU of our hospital from July 2013 to December 2014 were continuously selected for the study. The total serum bilirubin (TSB) was higher than 342 μmo/l, and was dominated by a higher amount of unconjugated bilirubin. Read More

    Tubular Dysfunction Mimicking Dent's Disease in 2 Infants Born with Extremely Low Birth Weight.
    Case Rep Nephrol Dial 2017 Jan-Apr;7(1):13-17. Epub 2017 Jan 20.
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.
    Two preterm infants, with extremely low birth weight born at gestational weeks 24 and 25, showed generalized proximal tubular dysfunction during their stay in the neonatal intensive care unit, including glucosuria, low molecular weight proteinuria, phosphaturia, uricosuria, enzymuria (elevated urine N-acetyl-β-D-glucosaminidase), panaminoaciduria, and hypercalciuria, associated with renal calcification. Renal tubular acidosis was not present in either patient. DNA mutation analysis for Dent's disease, performed in patient 1, was negative. Read More

    The Dramatic Recovery of a Patient with Biguanide-associated Severe Lactic Acidosis Following Thiamine Supplementation.
    Intern Med 2017 15;56(4):455-459. Epub 2017 Feb 15.
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan.
    Biguanides are a drug of choice for the treatment of type 2 diabetes mellitus. Although they can cause lactic acidosis in susceptible patients with predisposing risk factors, the incidence of lactic acidosis is reported to be very low when they are used properly. We herein present a case of biguanide-associated severe lactic acidosis complicated with thiamine deficiency that was provoked without predisposing factors for thiamine deficiency. Read More

    [MELAS: Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes].
    Brain Nerve 2017 Feb;69(2):111-117
    Department of Neurology, Showa University School of Medicine.
    Mitochondrial disease is caused by a deficiency in the energy supply to cells due to mitochondrial dysfunction. Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) is a mitochondrial disease that presents with stroke-like episodes such as acute onset of neurological deficits and characteristic imaging findings. Stroke-like episodes in MELAS have the following features: 1) neurological deficits due to localization of lesions in the brain, 2) episodes often accompany epilepsy, 3) lesions do not follow the vascular supply area, 4) lesions are more often seen in the posterior brain than in the anterior brain, 5) lesions spread to an adjacent area in the brain, and 6) neurological symptoms often disappear together with imaging findings, but later relapse. Read More

    Lethal neonatal case and review of primary short-chain enoyl-CoA hydratase (SCEH) deficiency associated with secondary lymphocyte pyruvate dehydrogenase complex (PDC) deficiency.
    Mol Genet Metab 2017 Feb 2. Epub 2017 Feb 2.
    Departments of Clinical Chemistry and Pediatrics, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
    Mutations in ECHS1 result in short-chain enoyl-CoA hydratase (SCEH) deficiency which mainly affects the catabolism of various amino acids, particularly valine. We describe a case compound heterozygous for ECHS1 mutations c.836T>C (novel) and c. Read More

    [Oliguria and acute renal dysfunction in a six-month-old infant].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Feb;19(2):203-207
    Department of ICU, Zhengzhou Children's Hospital, Zhengzhou 450003, China.
    The infant (a girl aged 6 months) was admitted to the hospital because of oliguria and acute renal dysfunction. The laboratory examination results showed serious metabolic acidosis and increased blood urea nitrogen and serum creatinine levels. The patient continued to be anuric after 10 days of treatment with continuous renal replacement therapy (CRRT). Read More

    Hyperchloremic Metabolic Acidosis Following Total Gut Irrigation with Normal Saline in Pediatric Patients: A Rare Occurrence.
    Indian J Crit Care Med 2017 Jan;21(1):55-56
    Department of Paediatric Surgery, Post Graduate Institute and Medical Education Research, Chandigarh, India.
    Use of 0.9% sodium chloride for total gut irrigation (TGI) through nasogastric route is an effective method of bowel preparation in children undergoing colorectal surgeries. TGI with normal saline (NS) can result in nausea, vomiting, abdominal distension, and mild electrolyte imbalance; however, hyperchloremic metabolic acidosis has not been documented. Read More

    Antiretroviral therapy related adverse effects: Can sub-Saharan Africa cope with the new "test and treat" policy of the World Health Organization?
    Infect Dis Poverty 2017 Feb 15;6(1):24. Epub 2017 Feb 15.
    Department of Epidemiology and Public Health, Centre Pasteur of Cameroon, Yaoundé, Cameroon.
    Background: Recent studies have shown that early antiretroviral therapy (ART) initiation results in significant HIV transmission reduction. This is the rationale behind the "test and treat" policy of the World Health Organization (WHO). Implementation of this policy will lead to an increased incidence of ART-related adverse effects, especially in sub-Saharan Africa (SSA). Read More

    Reversal of tumor acidosis by systemic buffering reactivates NK cells to express IFN-γ and induces NK cell-dependent lymphoma control without other immunotherapies.
    Int J Cancer 2017 Feb 13. Epub 2017 Feb 13.
    Institut für Molekulare Immunologie, Helmholtz-Zentrum München, Germany.
    Like other immune cells, natural killer (NK) cells show impaired effector functions in the microenvironment of tumors, but little is known on the underlying mechanisms. Since lactate acidosis, a hallmark of malignant tissue, was shown to contribute to suppression of effective antitumor immune responses, we investigated the impact of tissue pH and lactate concentration on NK-cell functions in an aggressive model of endogenously arising B-cell lymphoma. The progressive loss of IFN-γ production by NK cells observed during development of this disease could be ascribed to decreased pH values and lactate accumulation in the microenvironment of growing tumors. Read More

    The influence of mechanical ventilation on physiological parameters in ball pythons (Python regius).
    Comp Biochem Physiol A Mol Integr Physiol 2017 Feb 10;207:30-35. Epub 2017 Feb 10.
    Centre for Zoo and Wildlife Health, Copenhagen Zoo, Roskildevej 32, 2000 Frederiksberg, Denmark.
    Mechanical ventilation is widely recommended for reptiles during anesthesia, and while it is well-known that their low ectothermic metabolism requires much lower ventilation than in mammals, very little is known about the influence of ventilation protocol on the recovery from anesthesia. Here, 15 ball pythons (Python regius) were induced and maintained with isoflurane for 60min at one of three ventilation protocols (30, 125, or 250mlmin(-1)kg(-1) body mass) while an arterial catheter was inserted, and ventilation was then continued on 100% oxygen at the specified rate until voluntary extubation. Mean arterial blood pressure and heart rate (HR) were measured, and arterial blood samples collected at 60, 80, 180min and 12 and 24h after intubation. Read More

    Intermittent auscultation (IA) of fetal heart rate in labour for fetal well-being.
    Cochrane Database Syst Rev 2017 Feb 13;2:CD008680. Epub 2017 Feb 13.
    Liggins Institute, The University of Auckland, Park Road, Grafton, Auckland, New Zealand, 1142.
    Background: The goal of fetal monitoring in labour is the early detection of a hypoxic baby. There are a variety of tools and methods available for intermittent auscultation (IA) of the fetal heart rate (FHR). Low- and middle-income countries usually have only access to a Pinard/Laënnec or the use of a hand-held Doppler device. Read More

    Metabolic acidosis status and mortality in patients on the end stage of renal disease.
    J Transl Int Med 2016 Dec 30;4(4):170-177. Epub 2016 Dec 30.
    The First Department of Medicine, Propaedaetic, National & Kapodistrian University of Athens, School of Medicine, Athens, Greece.
    Background And Objectives: Uncorrected metabolic acidosis leads to higher death risk in dialysis patients. We observed the relationship between metabolic acidosis status and mortality rate in patients on renal replacement therapy during a median follow up time of 60 months.

    Methods: We studied 76 patients on an on-line hemodiafiltration. Read More

    Transdermal Spirit (Methanol) Poisoning: A Case Report.
    Iran Red Crescent Med J 2016 Nov 25;18(11):e23767. Epub 2016 Jan 25.
    Department of Emergency Medicine, Bagcilar Research and Training Hospital, Istanbul, Turkey.
    Introduction: Methanol is a highly toxic substance and methanol poisoning results in severe health situations. Methanol poisoning occurs when it is consumed by various methods such as orally, by inhalation, and transdermally. Transdermal poisoning is rarely seen and causes severe health complications. Read More

    Defects in RNA metabolism in mitochondrial disease.
    Int J Biochem Cell Biol 2017 Feb 8. Epub 2017 Feb 8.
    Harry Perkins Institute of Medical Research and Centre for Medical Research, Level 7 QQ Block, QEII Medical Centre, 6 Verdun Street, Nedlands, WA 6009, Australia; School of Chemistry and Biochemistry, The University of Western Australia, Nedlands, Western Australia 6009, Australia. Electronic address:
    The expression of mitochondrially-encoded genes requires the efficient processing of long precursor RNAs at the 5' and 3' ends of tRNAs, a process which, when disrupted, results in disease. Two such mutations reside within mt-tRNA(Leu(UUR)); a m.3243A > G transition, which is the most common cause of MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes), and m. Read More

    Dynamics of acid-base and hematological regulation in day 15 chicken embryos (Gallus gallus domesticus) exposed to graded hypercapnia and hypoxia.
    Respir Physiol Neurobiol 2017 Feb 9;239:55-63. Epub 2017 Feb 9.
    Developmental Integrative Biology, Department of Biological Sciences, University of North Texas, 1155 Union Circle #305220, Denton, TX 76203, USA.
    Most experiments examining acid-base regulation of chicken embryos have employed static, single time point measurements rather than dynamic, multiple time point measurements that might reveal additional components of developing acid-base regulation. Thus, we studied blood acid-base balance and hematology of day 15 chicken embryos under 24h exposure to graded hypercapnia (1%-7% CO2) accompanied by graded hypoxia (20% O2 down to 13% O2). Across all hypercapnic/hypoxic environments, respiratory acidosis occurred 2h after exposure in proportion to the magnitude of hypercapnia. Read More

    Reply to Letter: Survival in extremely acidotic cardiac arrest patients depends on etiology of acidosis.
    Resuscitation 2017 Feb 9. Epub 2017 Feb 9.
    Division of General Anaesthesiology, Emergency and Intensive Care Medicine, Department of Anaesthesiology and Intensive Care Medicine, Graz, Austria; Department of Anaesthesia and Intensive Care Medicine, Hospital of St. John of God, Graz, Austria. Electronic address:

    [Systemic lupus erythematosus presenting as severe alveolar hypoventilation and the shrinking lung syndrome].
    Rev Mal Respir 2017 Feb 8. Epub 2017 Feb 8.
    Service des maladies respiratoires, unité Inserm 903, hôpital Maison-Blanche, CHU de Reims, 45, rue Cognacq-Jay, 51092 Reims cedex, France. Electronic address:
    Introduction: The shrinking lung syndrome (SLS) is a rare complication of systemic lupus erythematosus.

    Case Report: A 69-year-old man presented with exertional dyspnoea, muscle weakness, and weight loss of 15kg in 6months. Pulmonary function tests revealed a restrictive lung disorder, with a dramatic decrease in maximal inspiratory pressure (17% of theoretical value), and alveolar hypoventilation (pH 7. Read More

    Dietary acid load and blood pressure development in pregnancy: The Generation R Study.
    Clin Nutr 2017 Jan 29. Epub 2017 Jan 29.
    Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands; Leiden University College, The Hague, The Netherlands.
    Background & Aims: Dietary intake could induce a mild maternal metabolic acidosis that might lead to a higher level of blood pressure. Because studies in pregnancy are scarce, we evaluated the association between maternal dietary acid load and changes in blood pressure during pregnancy, pregnancy-induced hypertension and pre-eclampsia.

    Methods: We included 3411 pregnant women of Dutch ancestry from a prospective population-based cohort (Rotterdam, The Netherlands). Read More

    Ocean acidification adversely influences metabolism, extracellular pH and calcification of an economically important marine bivalve, Tegillarca granosa.
    Mar Environ Res 2017 Feb 1;125:82-89. Epub 2017 Feb 1.
    College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China. Electronic address:
    Oceanic uptake of CO2 from the atmosphere has significantly reduced surface seawater pH and altered the carbonate chemistry within, leading to global Ocean Acidification (OA). The blood clam, Tegillarca granosa, is an economically and ecologically significant marine bivalve that is widely distributed along the coastal and estuarine areas of Asia. To investigate the physiological responses to OA, blood clams were exposed to ambient and three reduced seawater pH levels (8. Read More

    Therapeutic implications of tumor interstitial acidification.
    Semin Cancer Biol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute, Stockholm, Sweden. Electronic address:
    Interstitial acidification is a hallmark of solid tumor tissues resulting from the combination of different factors, including cellular buffering systems, defective tissue perfusion and high rates of cellular metabolism. Besides contributing to tumor pathogenesis and promoting tumor progression, tumor acidosis constitutes an important intrinsic and extrinsic mechanism modulating therapy sensitivity and drug resistance. In fact, pharmacological properties of anticancer drugs can be affected not only by tissue structure and organization but also by the distribution of the interstitial tumor pH. Read More

    Clinical and molecular aspects of distal renal tubular acidosis in children.
    Pediatr Nephrol 2017 Feb 10. Epub 2017 Feb 10.
    Department of Pediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, WC1N 3JH, UK.
    Background: Distal renal tubular acidosis (dRTA) is characterized by hyperchloraemic metabolic acidosis, hypokalaemia, hypercalciuria and nephrocalcinosis. It is due to reduced urinary acidification by the α-intercalated cells in the collecting duct and can be caused by mutations in genes that encode subunits of the vacuolar H(+)-ATPase (ATP6V1B1, ATP6V0A4) or the anion exchanger 1 (SLC4A1). Treatment with alkali is the mainstay of therapy. Read More

    Metformin-associated lactic acidosis treated with continuous renal replacement therapy.
    BMJ Case Rep 2017 Feb 10;2017. Epub 2017 Feb 10.
    Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Japan.
    Metformin-associated lactic acidosis (MALA) is a rare but life-threatening complication. We report a case of MALA in a man aged 71 years who was treated with continuous renal replacement therapy (CRRT). The patient was brought to the hospital for prolonged and gradual worsening gastrointestinal symptoms. Read More

    Indomethacin therapy effective in a patient with depletion syndrome from secretory villous adenoma.
    BMJ Case Rep 2017 Feb 10;2017. Epub 2017 Feb 10.
    Ross University School of Medicine, North Brunswick, New Jersey, USA.
    This paper details the case of a 26-year-old woman with depletion syndrome and the effectiveness of her treatment with indomethacin. Villous adenomas are benign neoplasms with a high incidence of becoming malignant. A small percentage of villous adenomas are known to cause depletion syndrome, also referred to as the McKittrick-Wheelock syndrome, a condition characterised by secretory diarrhoea, dehydration, hyponatremia, hypokalaemia, hypochloraemia, metabolic acidosis and acute renal failure. Read More

    Lactic Acidosis with Chloramphenicol Treatment in a Child with Cystic Fibrosis.
    J Popul Ther Clin Pharmacol 2017 Jan 30;24(1):40-45. Epub 2017 Jan 30.
    Department of Pediatrics, University of Montreal.
    Children with cystic fibrosis are commonly colonized with multi-resistant bacteria. In such patients, infectious exacerbation may require salvage therapy with uncommonly used antimicrobials, including chloramphenicol. Chloramphenicol is rarely used nowadays because of the associated severe adverse events. Read More

    [Hemorrhagic shock : General principles].
    Internist (Berl) 2017 Feb 9. Epub 2017 Feb 9.
    Klinik für Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.
    Bleeding associated with hemorrhagic shock is often seen in emergency medical services or in the intensive care unit. Identifying the origin of the bleeding and additional disorders helps to determine the degree of the hemorrhagic shock. In order to be effective, the initial therapy until blood products are available needs to be differentiated to be effective in terms of hemodynamic stabilization and coagulation. Read More

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