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    1 OF 969

    Systemic and transdermal melatonin administration prevents neuropathology in response to perinatal asphyxia in newborn lambs.
    J Pineal Res 2018 Feb 21. Epub 2018 Feb 21.
    The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
    Perinatal asphyxia remains a principal cause of infant mortality and long term neurological morbidity, particularly in low resource countries. No neuroprotective interventions are currently available. Melatonin (MLT), a potent antioxidant, anti-inflammatory, and anti-apoptotic agent offers promise as an intravenous (IV) or transdermal therapy to protect the brain. Read More

    Inalambric Biofeedback Devices to Analyze Strength Manifestation in Military Population.
    J Med Syst 2018 Feb 20;42(4):60. Epub 2018 Feb 20.
    Center for Higher Studies in Applied Combat, Toledo, Spain.
    The study of the effect of stress on both combatants physiological and anatomical systems have been poor studied in the specific literature. The present research aimed to study the effect of combat stress in strength manifestations of leg flexor-extensor muscles and the anaerobic metabolism of soldiers. Before and after asymmetrical combat simulation were analyzed parameters of blood lactate concentration, explosive leg strength manifestation and contractile capacity of leg muscle in 186 professional soldiers. Read More

    Reversible Dilation of Cerebral Macrovascular Changes in MELAS Episodes.
    Clin Neuroradiol 2018 Feb 20. Epub 2018 Feb 20.
    Department of Radiology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai, China.
    Purpose: To investigate the cerebral macrovascular changes as well as the relationship of large vessels and cerebral blood flow (CBF) in mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) using magnetic resonance angiography (MRA) and arterial spin labeling (ASL) perfusion MR imaging (MRI).

    Methods: A total of 20 patients diagnosed with MELAS (12 males, 8 females; mean age, 23.3 years) underwent conventional MRI, time-of-flight (TOF) MRA and three dimensional ASL. Read More

    [Metabolic complications of chronic kidney disease].
    Nephrol Ther 2017 Jun;13(6S):S30-S36
    Service de Néphrologie, Hôpital Necker-Enfants Malades, 149 rue de Sèvres 75015 Paris. Electronic address:
    Patients with Chronic Kidney Disease (CKD) are at risk of various metabolic complications, which can lead to health issues and even be life-threatening if not correctly treated, whereas they can be anticipated. Through clinical cases of patients taken from the daily practice, we propose to look into three of these common complications, namely hypocalcemia, hyperkalemia and metabolic acidosis. From the diagnostic approach to the patient care, these cases provide the opportunity to recall the fundamentals of these disorders and to present the recent literature date enlightening the knowledge related to them. Read More

    Facing coagulation disorders after acute trauma.
    B-ENT 2016 ;Suppl 26(1):67-85
    Facing coagulation disorders after acute trauma.

    Problems/objectives: Trauma is the leading cause of mortality for persons between one and 44 years of age, essentially due to bleeding complications.

    Methodology: We screened the PubMed, Scopus and Cochrane Library databases, using specific keywords. Read More

    Term small-for-gestational-age infants from low risk women are at significantly greater risk of adverse neonatal outcomes.
    Am J Obstet Gynecol 2018 Feb 17. Epub 2018 Feb 17.
    Mater Research Institute - University of Queensland, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, Queensland, Australia, QLD 4101; Mater Mothers' Hospital, Raymond Terrace, South Brisbane, Queensland, Australia, QLD 4101; School of Medicine, The University of Queensland, Brisbane, Australia. Electronic address:
    Background: Small-for-gestational age (SGA) infants (birthweight <10centile) are at increased risk of perinatal complications but are frequently not identified antenatally, particularly in low risk women delivering at term (>37 weeks gestation). This is compounded by the fact that late pregnancy ultrasound is not the norm in many jurisdictions for this cohort of women. We thus investigated the relationship between birthweight <10centile and serious neonatal outcomes in low risk women at term. Read More

    Does Aerobic Respiration Produce Carbon Dioxide or Hydrogen Ion and Bicarbonate?
    Anesthesiology 2018 Feb 15. Epub 2018 Feb 15.
    From Medical Service, Veterans Affairs Puget Sound Health Care System, Seattle, Washington; and the Department of Medicine and of Physiology and Biophysics, University of Washington, Seattle, Washington.
    Maintenance of intracellular pH is critical for clinical homeostasis. The metabolism of glucose, fatty acids, and amino acids yielding the generation of adenosine triphosphate in the mitochondria is accompanied by the production of acid in the Krebs cycle. Both the nature of this acidosis and the mechanism of its disposal have been argued by two investigators with a long-abiding interest in acid-base physiology. Read More

    pH Modulation of Voltage-Gated Sodium Channels.
    Handb Exp Pharmacol 2018 Feb 20. Epub 2018 Feb 20.
    Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
    Changes in blood and tissue pH accompany physiological and pathophysiological conditions including exercise, cardiac ischemia, ischemic stroke, and cocaine ingestion. These conditions are known to trigger the symptoms of electrical diseases in patients carrying sodium channel mutations. Protons cause a diverse set of changes to sodium channel gating, which generally lead to decreases in the amplitude of the transient sodium current and increases in the fraction of non-inactivating channels that pass persistent currents. Read More

    Perioperative Complications of Congenital Diaphragmatic Hernia Repair.
    Eur J Pediatr Surg 2018 Feb 19. Epub 2018 Feb 19.
    Department of Pediatric Surgery, Hospital de Braga, Braga, Portugal.
    Although improvements have been made, the management of congenital diaphragmatic hernia (CDH) remains a major challenge for perinatologists and neonatal surgeons. Many aspects of the disease remain unknown and, being a rare entity, evidence-based data are hard to find. Surgical morbidity is considerable and affects long-term quality of life. Read More

    Endovascular repair with extracorporeal membrane oxygenation as a rescue strategy for aortobronchial fistula: a case report.
    JA Clin Rep 2017 9;3(1):34. Epub 2017 Jun 9.
    3Department of Anesthesia, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo, 152-8902 Japan.
    Aortobronchial fistula (ABF) is a rare and potentially lethal complication of thoracic aortic replacement surgery. Currently, thoracic endovascular aortic repair (TEVAR) has emerged as a less invasive alternative to open surgery for ABF to facilitate prompt hemostasis. However, there are no published reports of TEVAR for ABF, particularly for presentation with life-threatening respiratory failure from massive hemoptysis. Read More

    Abdominal compartment syndrome during hip arthroscopy for an acetabular fracture: a case report.
    JA Clin Rep 2017 8;3(1):24. Epub 2017 May 8.
    3Nissan Tamagawa Hospital, 4-8-1 Seta, Setagaya-ku, Tokyo, 158-0095 Japan.
    Background: We encountered a case of abdominal compartment syndrome during hip arthroscopic surgery, caused by the irrigation fluid flowing into the peritoneal cavity.

    Case Presentation: A 47-year-old male patient with the acetabulum fracture underwent open reduction and internal fixation with hip arthroscopy. Hypothermia, increased airway pressure (under volume-controlled ventilation) and oliguria were observed during the operation, and arterial blood gas analysis showed decreased oxygenation and metabolic acidosis. Read More

    Metformin-Induced Lactic Acidosis (MILA): A case report and review of current diagnostic paradigm.
    Am J Emerg Med 2018 Feb 15. Epub 2018 Feb 15.
    State University of New York (SUNY) Upstate Medical University, United States.
    A new diagnostic paradigm has been proposed to better categorize causes of Metformin-Associated Lactic Acidosis (MALA). The diagnostic criteria defines a link between Metformin and lactic acidosis if lactate is >5mmol/L, Ph<7.35 and Metformin assay >5mg/L. Read More

    Metformin in heart failure patients.
    Indian Heart J 2018 Jan - Feb;70(1):175-176. Epub 2017 May 15.
    King Saud bin Abdulaziz University for Health Sciences, COM-J King Abdul Aziz Medical City-WR, King Faisal Cardiac Center, Mail Code 6599, P.O. Box 9515, Jeddah, 21423, Saudi Arabia.
    The use of metformin was considered a contraindication in heart failure patients because of the potential risk of lactic acidosis; however, more recent evidence has shown that this should no longer be the case. We reviewed the current literature and the recent guideline to correct the misconception. Read More

    Is the fetal cerebroplacental ratio better that the estimated fetal weight in predicting adverse perinatal outcomes in a low risk cohort?
    J Matern Fetal Neonatal Med 2018 Feb 18:1-7. Epub 2018 Feb 18.
    a Mater Research Institute, University of Queensland , Brisbane , Australia.
    Objective: In high-risk pregnancies combining the cerebro-placental ratio (CPR) with the estimated fetal weight (EFW) improves the identification of vulnerable fetuses. The purpose of this study was to assess the CPR and EFW's ability to predict adverse obstetric and perinatal outcomes in a low-risk pregnancy, when measured late in gestation.

    Methods: This was a retrospective study of women who birthed at Mater Mothers Hospitals, Brisbane, Australia between 2010 and 2015. Read More

    The effect of alfalfa (Medicago sativa) silage chop length and inclusion rate within a total mixed ration on the ability of lactating dairy cows to cope with a short-term feed withholding and refeeding challenge.
    J Dairy Sci 2018 Feb 14. Epub 2018 Feb 14.
    Sustainable Agriculture and Food Systems Research Division, Centre for Dairy Research, School of Agriculture, Policy and Development, University of Reading, Whiteknights Road, Reading, RG6 6AR, UK. Electronic address:
    The objectives of the study were (1) to test whether 6 h of feed deprivation followed by refeeding induces an acidosis challenge in dairy cattle and (2) to quantify the acidosis challenge mitigation potential of increased alfalfa silage concentration in the diet. Alfalfa silage constituted either 25 or 75% of forage dry matter (DM) replacing corn silage [low (LA) or high alfalfa (HA)] and was chopped to either 14 or 19 mm theoretical length [short (S) or long (L)]. Dietary treatments LAS, LAL, HAS, or HAL were offered to 4 rumen-cannulated Holstein dairy cattle (161 d in milk; 5th or 6th parity) in a 4 × 4 Latin square design study with 21-d periods. Read More

    Muscle carnosine in experimental autoimmune encephalomyelitis and multiple sclerosis.
    Mult Scler Relat Disord 2018 Feb 11;21:24-29. Epub 2018 Feb 11.
    REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Agoralaan Building A, Diepenbeek, Belgium.
    Background: Muscle carnosine is related to contractile function (Cahandling) and buffering of exercise-induced acidosis. As these muscular functions are altered in Multiple Sclerosis (MS) it is relevant to understand muscle carnosine levels in MS.

    Methods: Tibialis anterior muscle carnosine was measured in an animal MS model (EAE, experimental autoimmune encephalomyelitis, n = 40) and controls (CON, n = 40) before and after exercise training (EAE, CON, 10d, 1 h/d, 24 m/min treadmill running) or sedentary conditions (EAE, CON). Read More

    An unusual presentation of primary pulmonary extranodal marginal zone lymphoma of mucosal associated lymphoid tissue: An autopsy case report.
    Exp Mol Pathol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Pathology, Harbor-UCLA Medical Center, 1000 W. Carson St., Torrance, CA, United States.
    A 40 year old female with no documented medical history presented to the Emergency Department with several days of lethargy and altered mental status. She was found to be anemic, thrombocytopenic, and hypotensive. The patient was found to be in severe metabolic acidosis, became bradycardic, and quickly deteriorated. Read More

    An upconversion nanoplatform with extracellular pH-driven tumor-targeting ability for improved photodynamic therapy.
    Nanoscale 2018 Feb 16. Epub 2018 Feb 16.
    Department of Chemistry, City University of Hong Kong, Kowloon Tong, Hong Kong SAR. and City University of Hong Kong Shenzhen Research Institute, Shenzhen, 518057, P. R. China.
    Upconversion nanoparticles (UCNPs) are widely utilized for photodynamic therapy (PDT) due to their specific upconverting luminescence that utilizes near infrared (NIR) light to excite photosensitizers (PSs) for PDT. The efficiency of UCNP-based PDT will be improved if the cancer-targeting property of nanomedicine is enhanced. Herein, we employed the pH low insertion peptide (pHLIP), a cancer-targeting moiety, to functionalize an 808 nm excited UCNP-based nanoplatform that has a minimized over-heating effect to perform PDT. Read More

    The role of disease-linked residue glutamine-913 in support of the structure and function of the human electrogenic sodium/bicarbonate cotransporter NBCe1-A.
    Sci Rep 2018 Feb 15;8(1):3066. Epub 2018 Feb 15.
    Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo: The State University of New York, Buffalo, New York, USA.
    Mutations in the sodium bicarbonate cotransporter NBCe1 (SLC4A4) cause proximal renal tubular acidosis (pRTA). We recently described a novel pRTA mutation p.Gln913Arg (Q913R), inherited in compound heterozygous form with p. Read More

    Rhabdomyolysis After Prolonged Surgery: Report of 2 Cases and Review of Literature.
    J Oral Maxillofac Surg 2018 Feb 2. Epub 2018 Feb 2.
    Assistant Professor, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA. Electronic address:
    Rhabdomyolysis is a condition in which damaged muscle tissue breaks down and intracellular contents, including myoglobin, are released into the circulation. This produces a nonspecific clinical syndrome including electrolyte disturbances, hypovolemia, metabolic acidosis, coagulopathies, and risk of acute kidney injury. Rhabdomyolysis has been reported as a complication of prolonged surgical procedures but has rarely been reported in the oral and maxillofacial surgery literature. Read More

    Human ASIC1a mediates stronger acid-induced responses as compared with mouse ASIC1a.
    FASEB J 2018 Feb 15:fj201701367R. Epub 2018 Feb 15.
    Department of Physiology and Cell Biology, College of Medicine, University of South Alabama, Mobile, Alabama, USA.
    Acid-sensing ion channels (ASICs) are the major proton receptor in the brain and a key mediator of acidosis-induced neuronal injuries in disease. Most of published data on ASIC function came from studies performed in mice, and relatively little is known about potential differences between human and mouse ASICs (hASIC and mASIC, respectively). This information is critical for us to better interpret the functional importance of ASICs in human disease. Read More

    Mammalian Cells Undergo Endoreduplication in Response to Lactic Acidosis.
    Sci Rep 2018 Feb 13;8(1):2890. Epub 2018 Feb 13.
    Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
    Polyploidization, a common event during the evolution of different tumours, has been proposed to confer selective advantages to tumour cells by increasing the occurrence of mutations promoting cancer progression and by conferring chemotherapy resistance. While conditions leading to polyploidy in cancer cells have been described, a general mechanism explaining the incidence of this karyotypic change in tumours is still missing. In this study, we tested whether a widespread tumour microenvironmental condition, low pH, could induce polyploidization in mammalian cells. Read More

    Intracellular pH Regulation in iPSCs-derived Astrocytes from Subjects with Chronic Mountain Sickness.
    Neuroscience 2018 Feb 10. Epub 2018 Feb 10.
    Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, United States; Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, United States; Rady Children's Hospital-San Diego, San Diego, CA 92123, United States. Electronic address:
    Chronic Mountain Sickness (CMS) occurs in high-altitude residents with major neurological symptoms such as migraine headaches, dizziness and cognitive deficits. Recent work demonstrated that highlanders have increased intracellular pH (pH) in their brain cells, perhaps for the sake of adaptation to hypoxemia and help to facilitate glycolysis, DNA synthesis, and cell cycle progression. Since there are well adapted (non-CMS) and maladapted (CMS) high-altitude dwellers, it is not clear whether pHis differently regulated in these two high-altitude populations. Read More

    Rhabdomyolysis in Stuve-Wiedemann syndrome.
    BMJ Case Rep 2018 Feb 8;2018. Epub 2018 Feb 8.
    Paediatric Department, University Hospital of Wales, Cardiff, UK.
    A 6-month-old male infant with Stuve-Wiedemann syndrome (SWS) presented with an acute respiratory arrest secondary to a rhinovirus respiratory infection from which he was rapidly resuscitated. He developed an acute kidney injury requiring supportive treatment and on day 3 of his illness was noted to have developed severe rhabdomyolysis (creatine kinase level 132 040 U/L (normal <320 U/L)). He was born from consanguineous parents with homozygous mutations in the leukaemia inhibitory factor receptor. Read More

    Food protein-induced enterocolitis syndrome: a challenging diagnosis.
    BMJ Case Rep 2018 Feb 8;2018. Epub 2018 Feb 8.
    Pediatrics Department, CHGE, Porto, Portugal.
    Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated gastrointestinal food hypersensitivity triggered by food proteins. It may present acutely, with repetitive vomiting, diarrhoea and lethargy leading to dehydration and eventually shock or insidiously with intermittent emesis, chronic diarrhoea or failure to thrive. We describe a paediatric male patient with recurrent sepsis-like episodes of fever, lethargy, ashen-grey skin colouration and vomiting followed by diarrhoea. Read More


    A Probable Topiramate-induced Limbs Paraesthesia and Rigid Fingers Flexion
    Curr Drug Saf 2018 02 12. Epub 2018 Feb 12.
    Unit of Pediatrics and Pediatric Emergency, University Hospital "Policlinico-Vittorio Emanuele", Catania. Italy.
    Topiramate is a well-known anticonvulsant drug with a broad spectrum of actions. It has been proposed in the treatment of several types of epileptic seizures both in monotherapy and in add-on. Its usage has been extended to other disorders including migraine, essential tremor, obesity, alcohol and drug addiction. Read More

    Effect of metformin on kidney function in patients with type 2 diabetes mellitus and moderate chronic kidney disease.
    Oncotarget 2018 Jan 17;9(4):5416-5423. Epub 2017 Dec 17.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Background: Impaired renal function can lead to the accumulation of metformin, and elevated concentrations of metformin have been associated with lactic acidosis. The aim of this study was to evaluate the effect of continuous metformin treatment in patients with type 2 diabetes mellitus (DM) and moderate chronic kidney disease (CKD) (estimated glomerular filtration rate (eGFR) 30-0 ml/min/1.73 m) on renal function. Read More

    Pediatric acute respiratory distress syndrome - current views.
    Exp Ther Med 2018 Feb 14;15(2):1775-1780. Epub 2017 Dec 14.
    Department of Neonatology, Xuzhou Chlidren's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
    Acute respiratory distress syndrome (ARDS) mainly involves acute respiratory failure. In addition to this affected patients feel progressive arterial hypoxemia, dyspnea, and a marked increase in the work of breathing. The only clinical solution for the above pathological state is ventilation. Read More

    Glucose Management in Hospitalized Patients.
    Am Fam Physician 2017 Nov;96(10):648-654
    University of Louisville School of Medicine, Louisville, KY, USA.
    Glucose management in hospitalized patients poses challenges to physicians, including identifying blood glucose targets, judicious use of oral diabetes mellitus medications, and implementing appropriate insulin regimens. Uncontrolled blood glucose levels can lead to deleterious effects on wound healing, increased risk of infection, and delays in surgical procedures or discharge from the hospital. Previously recommended strict blood glucose targets for hospitalized patients result in more cases of hypoglycemia without improvement in patient outcomes. Read More

    Extracorporeal carbon dioxide removal in acute exacerbations of chronic obstructive pulmonary disease.
    Ann Transl Med 2018 Jan;6(2):31
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
    Extracorporeal carbon dioxide removal (ECCOR) has been proposed as an adjunctive intervention to avoid worsening respiratory acidosis, thereby preventing or shortening the duration of invasive mechanical ventilation (IMV) in patients with exacerbation of chronic obstructive pulmonary disease (COPD). This review will present a comprehensive summary of the pathophysiological rationale and clinical evidence of ECCOR in patients suffering from severe COPD exacerbations. Read More

    NDUFB8 Mutations Cause Mitochondrial Complex I Deficiency in Individuals with Leigh-like Encephalomyopathy.
    Am J Hum Genet 2018 Feb 1. Epub 2018 Feb 1.
    Department of Pediatrics, Salzburger Landeskliniken and Paracelsus Medical University Salzburg, 5020 Salzburg, Austria. Electronic address:
    Respiratory chain complex I deficiency is the most frequently identified biochemical defect in childhood mitochondrial diseases. Clinical symptoms range from fatal infantile lactic acidosis to Leigh syndrome and other encephalomyopathies or cardiomyopathies. To date, disease-causing variants in genes coding for 27 complex I subunits, including 7 mitochondrial DNA genes, and in 11 genes encoding complex I assembly factors have been reported. Read More

    Predictors and Outcome of Acute Kidney Injury in Children with Diabetic Ketoacidosis.
    Indian Pediatr 2018 Feb 9. Epub 2018 Feb 9.
    Pediatric Emergency and Intensive Care Units, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    Objective: To identify predictors and outcome of acute kidney injury (AKI) in children with diabetic ketoacidosis (DKA) admitted to a Pediatric Intensive Care Unit (PICU).

    Methods: Retrospective case review of 79 children with DKA admitted between 2011-2014.

    Results: Twenty eight children developed AKI during the hospital stay; 20 (71. Read More

    8-year retrospective analysis of intravenous arginine therapy for acute metabolic strokes in pediatric mitochondrial disease.
    Mol Genet Metab 2018 Feb 2. Epub 2018 Feb 2.
    Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:
    Background: Intravenous (IV) arginine has been reported to ameliorate acute metabolic stroke symptoms in adult patients with Mitochondrial Encephalopathy with Lactic Acidosis and Stroke-like Episodes (MELAS) syndrome, where its therapeutic benefit is postulated to result from arginine acting as a nitric oxide donor to reverse vasospasm. Further, reduced plasma arginine may occur in mitochondrial disease since the biosynthesis of arginine's precursor, citrulline, requires ATP. Metabolic strokes occur across a wide array of primary mitochondrial diseases having diverse molecular etiologies that are likely to share similar pathophysiologic mechanisms. Read More

    Metformin-Associated Lactic Acidosis: A Case Report.
    Drug Saf Case Rep 2018 Feb 9;5(1). Epub 2018 Feb 9.
    Department of Pulmonary and Critical Care Medicine, Lahey Hospital and Medical Center, Burlington, MA, USA.
    A 54-year-old woman with type 2 diabetes mellitus, hypertension, and peripheral vascular disease developed life-threatening lactic acidosis during treatment with metformin for type 2 diabetes. The woman received metformin at 1000 mg orally twice a day for type 2 diabetes. She presented to our emergency department with a 3-day history of severe watery diarrhea, nausea, and vomiting. Read More

    Spin-lock imaging of early tissue pH changes in ischemic rat brain.
    NMR Biomed 2018 Feb 9. Epub 2018 Feb 9.
    Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.
    We have previously reported that the dispersion of spin-lattice relaxation rates in the rotating frame (R) of tissue water protons at high field can be dominated by chemical exchange contributions. Ischemia in brain causes changes in tissue pH, which in turn may affect proton exchange rates. Amide proton transfer (APT, a form of chemical exchange saturation transfer) has been shown to be sensitive to chemical exchange rates and able to detect pH changes non-invasively following ischemic stroke. Read More

    Outcome in early-onset fetal growth restriction is best combining computerized fetal heart rate analysis with ductus venosus Doppler: insights from the Trial of Umbilical and Fetal Flow in Europe.
    Am J Obstet Gynecol 2018 Feb;218(2S):S783-S789
    Department of Obstetrics, Gynecology, and VU University Medical Centre, Amsterdam and University Medical Centre Groningen, University of Groningen, The Netherlands.
    Background: Early-onset fetal growth restriction represents a particular dilemma in clinical management balancing the risk of iatrogenic prematurity with waiting for the fetus to gain more maturity, while being exposed to the risk of intrauterine death or the sequelae of acidosis.

    Objective: The Trial of Umbilical and Fetal Flow in Europe was a European, multicenter, randomized trial aimed to determine according to which criteria delivery should be triggered in early fetal growth restriction. We present the key findings of the primary and secondary analyses. Read More

    Nephropathic Cystinosis Mimicking Bartter Syndrome: a Novel Mutation.
    Iran J Kidney Dis 2018 Jan;12(1):61-63
    Kayseri Education and Research Hospital, Department of Pediatric Nephrology, Kayseri, Turkey.
    Cystinosis is a rare autosomal recessive disorder resulting from defective lysosomal transport of cystine due to mutations in the cystinosin lysosomal cystine transporter (CTNS) gene. The clinical phenotype of nephropathic cystinosis is characterized by renal tubular Fanconi syndrome and development of end-stage renal disease during the first decade. Although metabolic acidosis is the classically prominent finding of the disease, a few cases may present with hypokalemic metabolic alkalosis mimicking Bartter syndrome. Read More

    Extracellular acidosis suppresses calcification of vascular smooth muscle cells by inhibiting calcium influx via L-type calcium channels.
    Clin Exp Hypertens 2018 Feb 8:1-8. Epub 2018 Feb 8.
    a Departments of Nephrology , The Fourth Hospital of Hebei Medical University , Shijiazhuang , P. R. China.
    Vascular calcification such as arteriosclerosis, which is characterized by a calcification of the tunica media, is a severe complication of chronic kidney disease (CKD), contributing to the high prevalence of cardiovascular morbidity and mortality in patients with CKD. An essential step during the development of arteriosclerosis is the transdifferentiation/calcification of vascular smooth muscle cells (VSMCs), resembling osteogenesis. Metabolic acidosis, a common clinical manifestation in CKD, is known to decrease vascular calcification. Read More

    Challenges in the diagnosis of acute cyanide poisoning.
    Clin Toxicol (Phila) 2018 Feb 8:1-9. Epub 2018 Feb 8.
    a Division of Medical Toxicology, Department of Emergency Medicine , University of Virginia School of Medicine , Charlottesville , VA , USA.
    Objective: The aim of this systematic review was to identify isolated acute cyanide poison cases and to identify reported signs, symptoms, and laboratory findings.

    Methods: We searched MEDLINE, Cochrane Reviews, and Web of Science case reports and series using a number of MeSH descriptors pertaining to cyanide, toxicity, and poisonings. We excluded studies on plants, laboratory analyses, smoke inhalation poisonings, animals as well as non-English language articles and those in which data were not available. Read More

    Effect of lactate versus acetate-based intravenous fluids on acid-base balance in patients undergoing free flap reconstructive surgeries.
    J Anaesthesiol Clin Pharmacol 2017 Oct-Dec;33(4):514-519
    Department of Anaesthesiology, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India.
    Background And Aims: Use of lactated intravenous fluids during long surgeries could cause lactate accumulation and lactic acidosis. Acetate-based solutions could be advantageous as they are devoid of lactate. The primary aim of the study was to assess the effect of use of an acetated solution or Ringer's lactate (RL) as intraoperative fluid on lactate levels in patients without hepatic dysfunction undergoing prolonged surgeries. Read More

    A non-interventional comparative study of the 20:1 combination of cafedrine/theodrenaline versus ephedrine for the treatment of intraoperative arterial hypotension: the HYPOTENS study design and rationale.
    Curr Med Res Opin 2018 Feb 7:1-17. Epub 2018 Feb 7.
    f University Hospital Würzburg, Department of Anaesthesia and Critical Care , Würzburg , Germany.
    Objective: To compare the effectiveness of 20:1 cafedrine/theodrenaline approved for use in Germany to ephedrine in the restoration of arterial blood pressure and on postoperative outcomes in patients with intraoperative arterial hypotension of any origin under standard clinical practice conditions.

    Methods And Results: 'HYPOTENS' is a national, multicenter, prospective, open-label, two-armed, non-interventional study. Effectiveness and post-operative outcome following cafedrine/theodrenaline or ephedrine therapy will be evaluated in two cohorts of hypotensive patients. Read More

    Bacteremia and Septic Arthritis due to a Nontoxigenic Strain ofin a Patient With Sickle Cell Disease.
    Open Forum Infect Dis 2018 Feb 2;5(2):ofx278. Epub 2018 Jan 2.
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
    A 22-year-old female with sickle cell disease presented with fevers, bilateral knee pain, and lethargy. Laboratory data revealed a leukocytosis and lactic acidosis. Blood and synovial fluid cultures grew a non-toxin-producing strain of. Read More

    Metatranscriptome Sequencing Reveals Insights into the Gene Expression and Functional Potential of Rumen Wall Bacteria.
    Front Microbiol 2018 23;9:43. Epub 2018 Jan 23.
    Department for Farm Animals and Veterinary Public Health, Institute of Milk Hygiene, Milk Technology and Food Science, University of Veterinary Medicine Vienna, Vienna, Austria.
    Microbiota of the rumen wall constitute an important niche of rumen microbial ecology and their composition has been elucidated in different ruminants during the last years. However, the knowledge about the function of rumen wall microbes is still limited. Rumen wall biopsies were taken from three fistulated dairy cows under a standard forage-based diet and after 4 weeks of high concentrate feeding inducing a subacute rumen acidosis (SARA). Read More

    Utility of prenatal Doppler ultrasound to predict neonatal impaired cerebral autoregulation.
    J Perinatol 2018 Feb 6. Epub 2018 Feb 6.
    Pediatrics, University of Maryland, Baltimore, MD, USA.
    Objective: Determine if abnormal prenatal Doppler ultrasound indices are predictive of postnatal impaired cerebral autoregulation.

    Study Design: Prospective cohort study of 46 subjects, 24-29weeks' gestation. Utilizing near-infrared spectroscopy and receiver-operating characteristic analysis, impaired cerebral autoregulation was defined as >16. Read More

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