48,967 results match your criteria Metabolic Acidosis

An Exceptional Neurosurgical Presentation of a Patient with Osteopetrosis.

World Neurosurg 2018 Jun 20. Epub 2018 Jun 20.

Istanbul University, Cerrahpasa Medical Faculty, Department of Neurosurgery, Kocamustafapaşa Cd No:53 34098, Fatih, Istanbul, Turkey. Electronic address:

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The reciprocal function and regulation of tumor vessels and immune cells offers new therapeutic opportunities in cancer.

Semin Cancer Biol 2018 Jun 20. Epub 2018 Jun 20.

(a)VIB-Center for Cancer Biology, and KU Leuven, Department of Oncology, 3000 Leuven, Belgium; (b)Department of Neurological Surgery, Brain Tumor Research Center, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, 94158, USA. Electronic address:

Tumor angiogenesis and escape of immunosurveillance are two cancer hallmarks that are tightly linked and reciprocally regulated by paracrine signaling cues of cell constituents from both compartments. Formation and remodeling of new blood vessels in tumors is abnormal and facilitates immune evasion. In turn, immune cells in the tumor, specifically in context with an acidic and hypoxic environment, can promote neovascularization. Read More

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Magnetic resonance imaging of arterial stroke mimics: a pictorial review.

Insights Imaging 2018 Jun 22. Epub 2018 Jun 22.

Department of Diagnostic and Therapeutic Neuroradiology, Hôpital Purpan, Place du Docteur Baylac, TSA 40031, 31059, Toulouse, France.

Acute ischaemic stroke represents the most common cause of new sudden neurological deficit, but other diseases mimicking stroke happen in about one-third of the cases. Magnetic resonance imaging (MRI) is the best technique to identify those 'stroke mimics'. In this article, we propose a diagnostic approach of those stroke mimics on MRI according to an algorithm based on diffusion-weighted imaging (DWI), which can be abnormal or normal, followed by the results of other common additional MRI sequences, such as T2 with gradient recalled echo weighted imaging (T2-GRE) and fluid-attenuated inversion recovery (FLAIR). Read More

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Metabolic Changes with Base-Loading in CKD.

Clin J Am Soc Nephrol 2018 Jun 22. Epub 2018 Jun 22.

Department of Medicine, Albert Einstein College of Medicine, Bronx, New York; and.

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June 2018
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A case risk study of lactic acidosis risk by metformin use in type 2 diabetes mellitus tuberculosis coinfection patients.

Indian J Tuberc 2018 Jul 3;65(3):252-256. Epub 2017 Jun 3.

Department of Clinical Microbology, Faculty of Medicine Airlangga University/Dr. Soetomo Hospital, Indonesia.

Metformin (MET) has possibilities to be utilized as an adjunct of tuberculosis (TB) therapy for controlling the growth of Mycobacterium tuberculosis (M. tuberculosis). MET enhances the production of mitochondrial reactive oxygen species and facilitates phagosome-lysosome fusion; those mechanism are important in M. Read More

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Extensive brain infarction and acute kidney injury in a young adult with methanol intoxication: A case report and review of the literature

Clin Nephrol 2018 Jun 22. Epub 2018 Jun 22.

Introduction: Methanol intoxication is an infrequent cause of poisoning in the United Sates. It can present with prominent stroke-like features and acute kidney injury. Despite the life-threatening nature of this condition, it is poorly identified by clinicians. Read More

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Role of interleukin-32 in cancer biology.

Oncol Lett 2018 Jul 7;16(1):41-47. Epub 2018 May 7.

Bone Marrow Transplantation Centre, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, P.R. China.

Interleukin-32 (IL-32), a novel proinflammatory cytokine, is highly expressed in various cancer tissues and in established cancer cell lines. IL-32 has been revealed to serve a crucial role in human cancer development, including tumour initiation, proliferation and maintenance. The expression of IL-32 is regulated by numerous factors, including genetic variations, hypoxia and acidosis in the tumour microenvironment. Read More

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Massive faecal impaction leading to abdominal compartment syndrome and acute lower limb ischaemia.

BMJ Case Rep 2018 Jun 20;2018. Epub 2018 Jun 20.

General and Endocrine Surgery, Footscray Hospital, Footscray, Victoria, Australia.

Abdominal compartment syndrome (ACS) is associated with significant morbidity and mortality requiring prompt treatment. We report a rare case of a 57-year-old man who developed acute lower limb ischaemia, severe metabolic acidosis and renal impairment from massive faecal impaction of unknown aetiology resulting in ACS causing occlusion of the right common iliac artery. This was treated with faecal disimpaction, which eventually resulted in slow but full recovery. Read More

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The MELAS mutation m.3243A>G promotes reactivation of fetal cardiac genes and an epithelial-mesenchymal transition-like program via dysregulation of miRNAs.

Biochim Biophys Acta 2018 Jun 18. Epub 2018 Jun 18.

RNA Modification and Mitochondrial Diseases Laboratory, Centro de Investigación Príncipe Felipe (CIPF), Carrer d'Eduardo Primo Yúfera 3, Valencia 46012, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) node 721, Madrid 28029, Spain. Electronic address:

The pathomechanisms underlying oxidative phosphorylation (OXPHOS) diseases are not well-understood, but they involve maladaptive changes in mitochondria-nucleus communication. Many studies on the mitochondria-nucleus cross-talk triggered by mitochondrial dysfunction have focused on the role played by regulatory proteins, while the participation of miRNAs remains poorly explored. MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) is mostly caused by mutation m. Read More

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Lactic acid induces lactate transport and glycolysis/OXPHOS interconversion in glioblastoma.

Biochem Biophys Res Commun 2018 Jun 20. Epub 2018 Jun 20.

Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, China.

The Warburg effect is a dominant phenotype of most tumor cells. Recent reports have shown that the Warburg effect can be reprogrammed by the tumor microenvironment. Lactic acidosis and glucose deprivation are the common adverse microenvironments in solid tumor. Read More

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Paraneoplastic Pemphigus as a First Manifestation of an Intra-Abdominal Follicular Dendritic Cell Sarcoma: Rare Case and Review of the Literature.

Case Rep Oncol 2018 May-Aug;11(2):353-359. Epub 2018 May 31.

Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Background: Follicular dendritic cell sarcoma (FDCS) is an extremely rare malignant tumor caused by proliferation of antigen-presenting follicular dendritic cells. The tumor most commonly arises in lymph nodes, with fewer than 30% of cases originating in extranodal sites.

Case Presentation: We report the case of a 39-year-old previously healthy male patient who presented with paraneoplastic pemphigus in the setting of a large intraperitoneal mass with no associated lymphadenopathy. Read More

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Bacteria, Bones, and Stones: Managing Complications of Short Bowel Syndrome.

Nutr Clin Pract 2018 Jun 21. Epub 2018 Jun 21.

Department of Internal Medicine and Surgery, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.

Short bowel syndrome (SBS) occurs in patients who have had extensive resection. The primary physiologic consequence is malabsorption, resulting in fluid and electrolyte abnormalities and malnutrition. Nutrient digestion, absorption, and assimilation may also be diminished by disturbances in the production of bile acids and digestive enzymes. Read More

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Clinical, biochemical, and pathophysiological analysis of SLC34A1 mutations.

Physiol Rep 2018 Jun;6(12):e13715

Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle, United Kingdom.

Mutations in SLC34A1, encoding the proximal tubular sodium-phosphate transporter NaPi-IIa, may cause a range of clinical phenotypes including infantile hypercalcemia, a proximal renal Fanconi syndrome, which are typically autosomal recessive, and hypophosphatemic nephrolithiasis, which may be an autosomal dominant trait. Here, we report two patients with mixed clinical phenotypes, both with metabolic acidosis, hyperphosphaturia, and renal stones. Patient A had a single heterozygous pathogenic missense mutation (p. Read More

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Management of adult-onset methylmalonic acidemia with hypotonia and acute respiratory failure: A case report.

Medicine (Baltimore) 2018 Jun;97(25):e11162

Division of Chest Medicine, Department of Internal Medicine, Far Eastern Memorial Hospital, Ban-Chiao District, New Taipei City, Taiwan.

Rationale: Methylmalonic acidemia (MMA) is an autosomal recessive disease of organic acidemia.

Patient Concerns: We report a 26-year-old male who presented with metabolic acidosis, acute renal failure required hemodialysis and acute respiratory failure required mechanical ventilation support. Progressive hypotonia of muscles made weaning from mechanical ventilator difficult. Read More

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Abdominal compartment syndrome and ruptured aortic aneurysm: Validation of a predictive test (SCA-AAR).

Medicine (Baltimore) 2018 Jun;97(25):e11066

Vascular Surgery Unit, University Hospital of Besançon.

Background: The abdominal compartment syndrome (ACS) has been clearly identified as being one of the main causes of mortality after ruptured abdominal aortic aneurysm (rAAA). The ACS is defined as a sustained intra-abdominal pressure > 20 mm Hg associated with a new organ dysfunction or failure. A pilot study was conducted and found that the threshold of 3 among 8 selected criteria, we would predict an ACS occurrence with a 54% positive predictive value and a 92% negative predictive value. Read More

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June 2018
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Euglycemic diabetic ketoacidosis caused by dapagliflozin: A case report.

Medicine (Baltimore) 2018 Jun;97(25):e11056

Department of Emergency Medicine, Chang Gung Memorial Hospital, Linkou.

Rationale: Diabetic ketoacidosis is a serious and potentially life-threatening acute complication of diabetes mellitus (DM). Euglycemic diabetic ketoacidosis (eDKA) is however challenging to identify in the emergency department (ED) due to absence of marked hyperglycemia, often leading to delayed diagnosis and treatment. eDKA has been recently found to be associated with sodium-glucose cotransporter 2 (SGLT2) inhibitors, one of the newest classes of antidiabetics, though there are very limited reports implicating dapagliflozin as the offending agent in ED patients. Read More

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The Hypothesis of Circulus Hypoxicus and Its Clinical Relevance in Patients with Methanol Poisoning - an Observational Study of 35 Patients.

Basic Clin Pharmacol Toxicol 2018 Jun 20. Epub 2018 Jun 20.

Department of Acute Medicine, Division of Medicine, Oslo University Hospital, Ulleval.

Methanol mass poisoning is a global problem with high fatality rates and often severe sequelae in survivors. Patients typically present late to the hospital with severe metabolic acidosis followed by a rapid deterioration in their clinical status. The hypothesis "Circulus hypoxicus" describes the metabolic acidosis following methanol poisoning as a self-enhancing hypoxic circle responsible for methanol toxicity. Read More

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June 2018
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A Homozygous Splice Site Mutation in SLC25A42, Encoding the Mitochondrial Transporter of Coenzyme A, Causes Metabolic Crises and Epileptic Encephalopathy.

JIMD Rep 2018 Jun 20. Epub 2018 Jun 20.

Institute of Human Genetics, Technische Universität München, Munich, Germany.

SLC25A42 is an inner mitochondrial membrane protein which has been shown to transport coenzyme A through a lipid bilayer in vitro. A homozygous missense variant in this gene has been recently reported in 13 subjects of Arab descent presenting with mitochondriopathy with variable clinical manifestations. By exome sequencing, we identified two additional individuals carrying rare variants in this gene. Read More

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June 2018
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Comparison of magnetic resonance spectroscopy (MRS) with arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic Acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS).

J Clin Neurosci 2018 Jun 16. Epub 2018 Jun 16.

Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

To compare the utility and limitation of magnetic resonance spectroscopy (MRS) and arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS), a retrospective review of 17 MELAS and 26 AIS patients were performed. In all patients both MRS and ASL scans were performed within 1 week after admission. Demographic, clinical, laboratory and MR imaging data were reviewed and compared between the two groups. Read More

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Predictive accuracy of cerebroplacental ratio for adverse perinatal and neurodevelopmental outcomes in suspected fetal growth restriction: systematic review and meta-analysis.

Ultrasound Obstet Gynecol 2018 Jun 19. Epub 2018 Jun 19.

Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Women's Centre, John Radcliffe Hospital, Oxford, OX3 9DU, UK.

Objective: The cerebroplacental ratio (CPR) has been proposed for the routine surveillance of pregnancies with suspected fetal growth restriction (FGR), but the predictive performance of this test is unclear. The aim of this study was to determine the accuracy of the CPR for predicting adverse perinatal and neurodevelopmental outcomes in suspected FGR.

Methods: PubMed, EMBASE, CINAHL, and Lilacs (all from inception to July 31, 2017) were searched for cohort or cross-sectional studies that reported on the accuracy of the CPR for predicting adverse perinatal and/or neurodevelopmental outcomes in singleton pregnancies with antenatally suspected FGR based on sonographic parameters. Read More

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June 2018
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Perinatal prediction model for severe intraventricular hemorrhage and the effect of early postnatal acidosis.

Childs Nerv Syst 2018 Jun 18. Epub 2018 Jun 18.

Department of Pediatrics, St. Vincent's Hospital, The Catholic University of Korea, Seoul, South Korea.

Purpose: Severe acidosis is one of the strongest predictors of neurologic outcomes in full-term infants with suspected hypoxic-ischemic encephalopathy. However, the relative importance of acidosis as a predictor of outcomes in preterm infants is much less clear. The goals of the present study were to examine the association between postnatal acidosis and severe intraventricular hemorrhage (IVH) and to establish a new score model including acid-base status after birth for predicting the risk of this morbidity. Read More

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June 2018
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Maternal overweight and obesity increase the risk of fetal acidosis during labor.

J Perinatol 2018 Jun 19. Epub 2018 Jun 19.

Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

Objective: To investigate whether maternal overweight and obesity increased the risk of fetal acidosis measured in umbilical cord arterial blood after delivery.

Study Design: Population-based cohort study of 84,785 term (≥37 weeks) infants. Logistic regression was used to estimate risks of fetal acidosis in umbilical cord arterial blood. Read More

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Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis.

Clin Transl Gastroenterol 2018 Jun 19;9(6):162. Epub 2018 Jun 19.

Division of Gastroenterology/Hepatology, Department of Internal Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.

Background: D-lactic acidosis is characterized by brain fogginess (BF) and elevated D-lactate and occurs in short bowel syndrome. Whether it occurs in patients with an intact gut and unexplained gas and bloating is unknown. We aimed to determine if BF, gas and bloating is associated with D-lactic acidosis and small intestinal bacterial overgrowth (SIBO). Read More

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Beware of beta! A case of salbutamol-induced lactic acidosis in severe asthma.

BMJ Case Rep 2018 Jun 17;2018. Epub 2018 Jun 17.

Our Lady's Hospital Navan, Navan, Ireland.

A 22-year-old woman presented with symptoms and signs consistent with acute severe asthma. After significant doses of beta-agonist, she developed a significant lactic acidosis. Significant issues arose in this patient's history with regards to purchase of medications, compliance and follow-up with respiratory service. Read More

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June 2018
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Favorable impact of thoracic endovascular aortic repair on survival of patients with acute uncomplicated type B aortic dissection.

J Vasc Surg 2018 Jun 15. Epub 2018 Jun 15.

Division of Vascular Surgery and Endovascular Interventions, New York-Presbyterian/Columbia University Irving Medical Center, New York, NY. Electronic address:

Background: In uncomplicated type B aortic dissection (UTBAD), the "gold standard" has been nonoperative treatment with medical therapy, although this has been questioned by studies demonstrating improved outcomes in those treated with thoracic endovascular aortic repair (TEVAR). This study assessed long-term survival after acute UTBAD comparing medical therapy, open repair, and TEVAR.

Methods: The California Office of Statewide Hospital Planning Development database was analyzed from 2000 to 2010 for adult patients with acute UTBAD. Read More

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Specific Inhibition of Hepatic Lactate Dehydrogenase Reduces Oxalate Production in Mouse Models of Primary Hyperoxaluria.

Mol Ther 2018 Jun 15. Epub 2018 Jun 15.

Dicerna Pharmaceuticals, Inc., Cambridge, MA 02140, USA. Electronic address:

Primary hyperoxalurias (PHs) are autosomal recessive disorders caused by the overproduction of oxalate leading to calcium oxalate precipitation in the kidney and eventually to end-stage renal disease. One promising strategy to treat PHs is to reduce the hepatic production of oxalate through substrate reduction therapy by inhibiting liver-specific glycolate oxidase (GO), which controls the conversion of glycolate to glyoxylate, the proposed main precursor to oxalate. Alternatively, diminishing the amount of hepatic lactate dehydrogenase (LDH) expression, the proposed key enzyme responsible for converting glyoxylate to oxalate, should directly prevent the accumulation of oxalate in PH patients. Read More

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June 2018
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Fatty and hydroxycarboxylic acid receptors: The missing link of immune response and metabolism in cattle.

Vet Immunol Immunopathol 2018 Jul 2;201:77-87. Epub 2018 Jun 2.

Laboratory of Molecular Pharmacology, Institute of Pharmacology, Faculty of Veterinary Science, Universidad Austral de Chile, Valdivia, Chile. Electronic address:

Fatty and hydroxycarboxylic acids are one of the main intermediates of energy metabolism in ruminants and critical in the milk production of cattle. High production demands on a dairy farm can induce nutritional imbalances and metabolism disorders, which have been widely associated with the onset of sterile inflammatory processes and increased susceptibility to infections. The literature suggests that short-chain fatty acids (SCFA), long-chain fatty acids (LCFA) and hydroxycarboxylic acids are relevant modulators of the host innate inflammatory response. Read More

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July 2018
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SLC4A4 compound heterozygous mutations in exon-intron boundary regions presenting with severe proximal renal tubular acidosis and extrarenal symptoms coexisting with Turner's syndrome: a case report.

BMC Med Genet 2018 Jun 18;19(1):103. Epub 2018 Jun 18.

Division of Nephrology and Endocrinology, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo, Tokyo, 113 0033, Japan.

Background: Congenital NBCe1A deficiency with the SLC4A4 mutation causes severe proximal renal tubular acidosis, which often comprises extrarenal symptoms, such as intellectual disability and developmental delay, glaucoma, cataract and band keratopathy. To date, almost all mutations have been found to be homozygous mutations located in exons.

Case Presentation: We performed direct nucleotide sequencing analysis of exons and exon-intron boundary regions of the SLC4A4 in a patient presenting with severe renal proximal tubule acidosis, glaucoma and intellectual disability and her parents without these signs. Read More

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Dietary Influence on Body Fluid Acid-Base and Volume Balance: The Deleterious "Norm" Furthers and Cloaks Subclinical Pathophysiology.

Qi Qian

Nutrients 2018 Jun 16;10(6). Epub 2018 Jun 16.

Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, School of Medicine, Rochester, MN 55905, USA.

The popular modern diet, characterized by an excess of animal protein and salt but insufficient in fruits, vegetables and water, is a poor fit for human physiological and homeostatic regulatory systems. Sustained net acid and sodium retention, coupled with an insufficient intake of cardiovascular protective potassium-rich foods and hydration in the modern diet can give rise to debilitating chronic organ dysfunction and ultimately, mortality. This holds true, especially in our aging population who are already facing inevitable decline in organ functional reserve. Read More

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June 2018
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Balanced Crystalloids Versus Saline for Perioperative Intravenous Fluid Administration in Children Undergoing Neurosurgery: A Randomized Clinical Trial.

J Neurosurg Anesthesiol 2018 Jun 15. Epub 2018 Jun 15.

Departments of Anesthesiology.

Background: Balanced crystalloid solutions induce less hyperchloremia than normal saline, but their role as primary fluid replacement for children undergoing surgery is unestablished. We hypothesized that balanced crystalloids induce less chloride and metabolic derangements than 0.9% saline solutions in children undergoing brain tumor resection. Read More

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June 2018
3 Reads

Neurological impairments in hypoxic neonates and lactate levels.

Neurol Res 2018 Jun 18:1-6. Epub 2018 Jun 18.

a Department of Neonatology , Clinic for Gynecology and Obstetrics Clinical Center of Serbia , Belgrade , Serbia.

Introduction: Metabolic acidosis with increasing lactate concentration develops due to the lack of oxygen in the tissues.

Objectives: The effect of lactic acidosis on neurological development in the first year of life.

Materials And Methods: Our study included 50 newborns with perinatal hypoxia requiring oxygen therapy and 50 healthy newborns. Read More

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A Case of Linezolid Induced Toxicity.

J Pharm Pract 2018 Jan 1:897190018782787. Epub 2018 Jan 1.

1 Department of Pharmacy, Rush University Medical Center, Chicago, IL, USA.

Adverse effects of linezolid are typically limited to diarrhea, nausea, and headache when shorter durations are used; however, as extended durations of linezolid therapy are increasingly more common, additional monitoring parameters should be considered in these patients. We describe a unique case of hypoglycemia, lactic acidosis, and pancreatitis related to an extended duration of linezolid therapy. A 52-year-old woman presented with altered mental status, abdominal pain, and hypotension following six weeks of linezolid and ertapenem therapy. Read More

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January 2018
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Hypokalemic Paralysis Due to Primary Sjogren Syndrome.

Anuj Sarma

Indian J Endocrinol Metab 2018 Mar-Apr;22(2):287-289

Department of Anaesthesia and Critical Care, Down Town Hospital, Gauhati, Assam, India.

Sjögren syndrome is an autoimmune disorder characterized by lymphocytic infiltration of exocrine gland. The most common symptom by virtue of its involvement includes dryness of eyes, mouth, and parotid gland enlargement. However, the disease may be associated with extraglandular manifestation affecting multiple organs. Read More

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Active Recovery between Interval Bouts Reduces Blood Lactate While Improving Subsequent Exercise Performance in Trained Men.

Sports (Basel) 2017 Jun 12;5(2). Epub 2017 Jun 12.

Faculty of Sports and Health Science, Doshisha University, Kyotanabe 610-0394, Japan.

This study aimed to examine the blood lactate and blood pH kinetics during high-intensity interval training. Seventeen well-trained athletes exercised on two different occasions. Exercises consisted of three 30 s bouts at a constant intensity (90% of peak power) with 4 min recovery between bouts followed by a Wingate test (WT). Read More

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June 2017
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Factors associated with delirium in critical patients in a health institution in Bucaramanga, Colombia.

Enferm Intensiva 2018 Jun 13. Epub 2018 Jun 13.

Semillero de Investigación CUIDEN, Programa de Enfermería, Universidad de Santander, Bucaramanga, Colombia.

Objective: To determine the incidence and the factors associated with delirium in intensive care unit patients.

Methods: A cohort study conducted on 134 patients in the intensive care unit at a clinic in Bucaramanga, Colombia., who were recruited in the first 24hours following admission and on whom the Richmond Agitation-Sedation Scale (RASS), PRE-DELIRIC version in Spanish, and Confusion Assessment method for Intensive Care Unit (CAM-ICU) were applied; the outcome was evaluated through daily monitoring with CAM-ICU. Read More

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June 2018
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Peritoneal lavage with povidone-iodine solution in colorectal cancer-induced rats.

J Surg Res 2018 Aug 25;228:93-99. Epub 2018 Apr 25.

Department of Anesthesiology, Ningxia Medical University, Yinchuan, Ningxia, China.

Background: Although peritoneal lavage with povidone-iodine (PVPI) is frequently performed after surgery on the gastrointestinal tract, the effects of PVPI on the intestinal epithelial barrier are unknown. The purpose of this study was to investigate the effects of abdominal irrigation with PVPI on the intestinal epithelial barrier in a colorectal cancer (CRC)-induced rat model.

Materials And Methods: The CRC model was induced in rats with azoxymethane and dextran sodium sulfate. Read More

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August 2018
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A case of Metaplastic atrophic gastritis in immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) syndrome.

BMC Pediatr 2018 Jun 15;18(1):191. Epub 2018 Jun 15.

Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: Autoimmune metaplastic atrophic gastritis is a chronic progressive inflammatory condition. The clinical spectrum includes pernicious anemia, atrophic gastritis, antibodies to parietal cell antigens and intrinsic factor, achlorhydria, hypergastrinemia and carcinoma. It is rare in paediatric cohorts. Read More

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June 2018
2 Reads

Severe renal Fanconi and management strategies in Arthrogryposis-Renal dysfunction-Cholestasis syndrome: a case report.

BMC Nephrol 2018 Jun 15;19(1):144. Epub 2018 Jun 15.

Pediatric Nephrology, Hospital Universitario Vall d'Hebron, Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain.

Background: Arthrogryposis-Renal dysfunction-Cholestasis syndrome (ARC, MIM#208085) is a rare multisystem disease due to mutations in the VPS33B and VIPAR genes, both involved in maintaining apical-basolateral cell polarity. The correlation between mutations and phenotype in the ARC Syndrome is not well described. We report on a 6 year old patient who presented with severe renal Fanconi as first manifestation of ARC related to a combined de novo mutation in the VPS33B gene. Read More

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Skeletal Consequences of Nephropathic Cystinosis.

J Bone Miner Res 2018 Jun 15. Epub 2018 Jun 15.

Skeletal Disorders and Mineral Homeostasis Section, National Institutes of Health, Bethesda, MD, United States.

Nephropathic cystinosis is a rare lysosomal storage disorder. Patients present in the first year of life with renal Fanconi syndrome that evolves to progressive chronic kidney disease (CKD). Despite the multiple risk factors for bone disease, the frequency and severity of skeletal disorders in nephropathic cystinosis have not been described. Read More

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June 2018
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Beta-alanine supplementation improves isometric, but not isotonic or isokinetic strength endurance in recreationally strength-trained young men.

Amino Acids 2018 Jun 15. Epub 2018 Jun 15.

Applied Physiology and Nutrition Research Group, Faculdade de Medicina FMUSP, Escola de Educação Física e Esporte, Universidade de São Paulo, Av. Melo de Moraes, 65, Butantã, São Paulo, SP, 05508-030, Brazil.

β-Alanine (BA) supplementation may be ergogenic during high-intensity exercise, primarily due to the buffering of hydrogen cations, although the effects of beta-alanine supplementation on strength endurance are equivocal. The aim of the study was to determine the effects of 4 weeks of beta-alanine supplementation on skeletal muscle endurance using a battery of performance tests. This study employed a parallel group, repeated measures, randomised, double-blinded and placebo-controlled design. Read More

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June 2018
3 Reads

Corrigendum to "Interleukin-1β and tumor necrosis factor-α augment acidosis-induced rat articular chondrocyte apoptosis via nuclear factor-kappaB-dependent upregulation of ASIC1a channel" [Biochimica et Biophysica Acta 1864/1 (2018) 162-177].

Biochim Biophys Acta 2018 Jun 11. Epub 2018 Jun 11.

Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Anti-inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education, Hefei 230032, China. Electronic address:

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Intestinal microbial and metabolic alterations following successful fecal microbiota transplant for D-lactic acidosis.

J Pediatr Gastroenterol Nutr 2018 Jun 12. Epub 2018 Jun 12.

Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Fecal microbiota transplantation (FMT) involves the transfer of stool from a healthy individual into the intestinal tract of a diseased recipient. Although used primarily for recurrent Clostridium difficile infection, FMT is increasingly being attempted as an experimental therapy for other illnesses, including metabolic disorders. D-lactic acidosis (D-LA) is a metabolic disorder that may occur in individuals with short bowel syndrome when lactate-producing bacteria in the colon overproduce D-lactate. Read More

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June 2018
3 Reads

Targeted resequencing of phosphorus metabolism‑related genes in 86 patients with hypophosphatemic rickets/osteomalacia.

Int J Mol Med 2018 Jun 13. Epub 2018 Jun 13.

Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China.

Hypophosphatemic rickets/osteomalacia is characterized by defective renal phosphate reabsorption and abnormal bone mineralization. Hypophosphatemic rickets/osteomalacia consists of inherited and acquired forms, many of which have unknown aetiology. In the present study, next‑generation sequencing‑based resequencing was used on samples from Chinese subjects with hypophosphatemic rickets/osteomalacia, aiming to detect the spectrum of pathogenic genes in these patients. Read More

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Intervention thresholds and cesarean section rates: a time-trends analysis.

Acta Obstet Gynecol Scand 2018 Jun 14. Epub 2018 Jun 14.

Obstetrics, University of Aberdeen, Aberdeen, UK.

Introduction: In order to improve understanding of rising cesarean section (CS) rates in the UK, this study assessed the relation between clinician thresholds for performing CS for delayed labor progress or suspected fetal distress and corresponding CS rates in Aberdeen, UK.

Material And Methods: Time-trends analysis of term births from 1988 to 2012 in a population of nulliparous women (n=53 745) in Aberdeen, UK using Chi-square test for trend, and binary logistic regression. Data was obtained from the Aberdeen Maternity and Neonatal Databank. Read More

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Fluid Composition, Infusion Rate, and Brain Injury in Diabetic Ketoacidosis.

Mark A Sperling

N Engl J Med 2018 06;378(24):2336-2338

From the Department of Pediatrics, Division of Endocrinology and Diabetes, Icahn School of Medicine at Mt. Sinai, New York.

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June 2018
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Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis.

N Engl J Med 2018 06;378(24):2275-2287

From the Departments of Emergency Medicine (N.K., L.T.), Pediatrics (N.K., N.S.G.), and Psychology (S.G., C.S.P.), University of California Davis Health, University of California, Davis, School of Medicine, Sacramento; the Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (J.E.S., C.S.O., T.C.C., J.M.D.); the Division of Emergency Medicine, Department of Pediatrics, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus (M.J.S.); the Division of Emergency Medicine, Department of Pediatrics, Colorado Children's Hospital, University of Colorado-Denver School of Medicine, Aurora (A.R.); the Division of Emergency Medicine, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston (J.K.M.); the Division of Emergency Medicine, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania (S.R.M.), and the Division of Emergency Medicine, Nemours/A.I. duPont Hospital for Children, Sidney Kimmel Medical College at Thomas Jefferson University (J.E.B., A.D.D.) - both in Philadelphia; the Division of Emergency Medicine, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston (L.E.N.); the Departments of Emergency Medicine and Pediatrics, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence (A.G.); the Division of Emergency Medicine, Department of Pediatrics, Children's National Medical Center, George Washington School of Medicine and Health Sciences, Washington, DC (K.M.B.); the Division of Emergency Medicine, Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine in St. Louis, St. Louis (K.S.Q.); the Division of Emergency Medicine, Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago (J.L.T.); and the Division of Emergency Medicine, Department of Pediatrics, New York Presbyterian Morgan Stanley Children's Hospital, Columbia University College of Physicians and Surgeons, New York (M.Y.K.); and the Department of Psychology, Tufts University, Medford, MA (C.S.P.).

Background: Diabetic ketoacidosis in children may cause brain injuries ranging from mild to severe. Whether intravenous fluids contribute to these injuries has been debated for decades.

Methods: We conducted a 13-center, randomized, controlled trial that examined the effects of the rate of administration and the sodium chloride content of intravenous fluids on neurologic outcomes in children with diabetic ketoacidosis. Read More

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June 2018
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Diagnosis and Treatment of Metabolic Acidosis in Patients with Chronic Kidney Disease - Position Statement of the Working Group of the Polish Society of Nephrology.

Kidney Blood Press Res 2018 Jun 7;43(3):959-969. Epub 2018 Jun 7.

Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland.

Metabolic acidosis is commonly found in patients with chronic kidney disease (CKD), and its causes are: impaired ammonia excretion, reduced tubular bicarbonate reabsorption and insufficient renal bicarbonate production in relation to the amount of acids synthesised by the body and ingested with food. As the consequence, numerous metabolic abnormalities develop, which may lead to dysfunction of several organs. In observational studies, it has been found that CKD patients with metabolic acidosis are characterised by faster progression of kidney disease towards end stage kidney failure, and by increased mortality. Read More

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June 2018
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H NMR metabolomics of microbial metabolites in the four MW agricultural biogas plant reactors: A case study of inhibition mirroring the acute rumen acidosis symptoms.

J Environ Manage 2018 Sep 9;222:428-435. Epub 2018 Jun 9.

Faculty of Civil and Geodetic Engineering, Hajdrihova 28, SI-1000, Ljubljana, Slovenia; Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia; Center for Clinical Neurophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Electronic address:

In this study, nuclear magnetic resonance (H NMR) spectroscopic profiling was used to provide a more comprehensive view of microbial metabolites associated with poor reactor performance in a full-scale 4 MW mesophilic agricultural biogas plant under fully operational and also under inhibited conditions. Multivariate analyses were used to assess the significance of differences between reactors whereas artificial neural networks (ANN) were used to identify the key metabolites responsible for inhibition and their network of interaction. Based on the results of nm-MDS ordination the subsamples of each reactor were similar, but not identical, despite homogenization of the full-scale reactors before sampling. Read More

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September 2018

Effective thiafentanil immobilization and physiological responses of free-ranging moose (Alces alces) in northern Sweden.

Vet Anaesth Analg 2018 Mar 31. Epub 2018 Mar 31.

Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden.

Objective: To evaluate clinical and physiological responses in moose to thiafentanil administration for immobilization.

Study Design: Cross-sectional clinical study.

Animals: Eleven (six males and five females) free-ranging adult moose (Alces alces). Read More

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Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolaviron Correlates with Reduction in Neurobehavioural Deficits.

Ann Neurosci 2018 Apr 23;25(1):53-62. Epub 2017 Nov 23.

Biochemical Pharmacology and Toxicology Laboratories, Department of Biochemistry, The Federal University of Technology, Akure, Nigeria.

Background: Disruption of electrolyte, redox and neurochemical homeostasis alongside cellular energy crisis is a hallmark of cerebral ischaemia and reperfusion injury.

Purpose: This study investigated the effect of kolaviron (KV) on cortical and striatal cation imbalance, oxidative stress and neurochemical disturbances as well as neurobehavioural deficits in animals subjected to bilateral common carotid artery occlusion (BCCAO)-induced ischaemia/reperfusion injury.

Methods: KV was administered at a dose of 100 or 200 mg/kg to male Wistar rats 1 h before a 30 min BCCAO/4 h reperfusion (I/R). Read More

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April 2018
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