9,429 results match your criteria Mesothelioma Malignant


Disparities in Compliance with National Guidelines for the Treatment of Malignant Pleural Mesothelioma.

Ann Thorac Surg 2019 Apr 17. Epub 2019 Apr 17.

Division of Thoracic Surgery, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA. Electronic address:

Background: Current guidelines support cancer-directed surgery, chemotherapy or active surveillance for clinical stages 1 to 3 of epithelial Malignant Pleural Mesothelioma (MPM). Definitive chemotherapy is recommended for sarcomatoid/biphasic histologies. Our objective is to assess compliance with recommendations, measuring their impact on overall survival (OS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975193055
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http://dx.doi.org/10.1016/j.athoracsur.2019.03.052DOI Listing
April 2019
1 Read

Thoracoscopic pericardiectomy associated with fully implantable catheter via thoracoscopy in the management of mesothelioma in a bitch.

J Vet Med Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Small Animal Clinics, Center of Rural Science, Federal University of Santa Maria (UFSM).

Mesothelioma is a very aggressive malignant tumor with low survival rates that is often diagnosed belatedly. Pericardial effusion is a common consequence in cases of mesothelioma, with pericardiocentesis and pericardiectomy indicated; therefor thoracocentesis is necessary to drain the contents no longer retained in the pericardium. The present report describes a mesothelioma - carrying dog with a history of cardiac tamponade that underwent thoracoscopic pericardiectomy and, later, thoracoscopic implantation of a fully implantable catheter to function as a thoracic drain. Read More

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https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_17
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http://dx.doi.org/10.1292/jvms.17-0631DOI Listing
April 2019
2 Reads

A phase 2, open-label study of brentuximab vedotin in patients with CD30-expressing solid tumors.

Invest New Drugs 2019 Apr 16. Epub 2019 Apr 16.

Indiana University Division of Hematology and Oncology, 535 Barnhill Dr, Indianapolis, IN, 46202, USA.

Purpose Brentuximab vedotin (BV) is an anti-CD30 antibody-drug conjugate used in the treatment of several types of lymphomas. Expression of the target antigen has also been reported on a variety of malignant tumors of nonlymphoid origin. This phase 2, open-label study evaluated the safety and antitumor activity of BV in patients with CD30-expressing nonlymphomatous malignancies. Read More

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http://link.springer.com/10.1007/s10637-019-00768-6
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http://dx.doi.org/10.1007/s10637-019-00768-6DOI Listing
April 2019
3 Reads

Chemotherapy Versus Supportive Care for Unresected Malignant Pleural Mesothelioma.

Clin Lung Cancer 2019 Mar 26. Epub 2019 Mar 26.

Department of Radiation Oncology, New York Proton Center, New York, NY. Electronic address:

Background: Management options for unresected malignant pleural mesothelioma (MPM) are largely limited to palliative chemotherapy and best supportive care. This study sought to delineate subgroups most likely to benefit from chemotherapy.

Patients And Methods: The National Cancer Database was queried for newly-diagnosed unresected sarcomatoid, biphasic, and/or metastatic (M1) MPM. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15257304193007
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http://dx.doi.org/10.1016/j.cllc.2019.03.003DOI Listing
March 2019
3 Reads

Primary malignant mesothelioma of the diaphragm with liver invasion: A case report and review of literature.

Medicine (Baltimore) 2019 Apr;98(15):e15147

Department of Pathology, The First Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning Province, China.

Rationale: Malignant mesothelioma is a malignant tumor with poor prognosis, which usually originates in the pleura, peritoneum, and pericardial cavity. Mesotheliomas that originate from the diaphragm are very rare. Here, we report a case of primary malignant mesothelioma of the diaphragm with liver invasion. Read More

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http://dx.doi.org/10.1097/MD.0000000000015147DOI Listing
April 2019
1 Read

The timing of chemotherapy in the management plan for medically operable early-stage malignant pleural mesothelioma.

Expert Rev Respir Med 2019 Apr 12. Epub 2019 Apr 12.

b Clinical Oncology Department , Ain Shams University , Cairo , Egypt .

Introduction: Trimodality therapy (including surgery, chemotherapy and radiation therapy) represents an important management approach of early-stage malignant pleural mesothelioma (MPM). The oncological value, as well as the proper sequence of the three modalities, is still under investigations. Areas Covered: The article covers the timing of chemotherapy in the management plan either "neoadjuvant approach" or in the adjuvant setting. Read More

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http://dx.doi.org/10.1080/17476348.2019.1607300DOI Listing
April 2019
1 Read

Inherited predisposition to malignant mesothelioma and overall survival following platinum chemotherapy.

Proc Natl Acad Sci U S A 2019 Apr 11. Epub 2019 Apr 11.

Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637.

Survival from malignant mesothelioma, particularly pleural mesothelioma, is very poor. For patients with breast, ovarian, or prostate cancers, overall survival is associated with increased sensitivity to platinum chemotherapy due to loss-of-function mutations in DNA repair genes. The goal of this project was to evaluate, in patients with malignant mesothelioma, the relationship between inherited loss-of-function mutations in DNA repair and other tumor suppressor genes and overall survival following platinum chemotherapy. Read More

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http://dx.doi.org/10.1073/pnas.1821510116DOI Listing
April 2019
2 Reads
9.809 Impact Factor

Family history of cancer and risk of paediatric and young adult's testicular cancer: A Norwegian cohort study.

Br J Cancer 2019 Apr 10. Epub 2019 Apr 10.

Institute of Health and Society, University of Oslo, P.O Box 1130 Blindervn, 0318, Oslo, Norway.

Background: The aim of this study was to examine the association of a family history of cancer with the risk of testicular cancer in young adults.

Methods: This is a prospective cohort study including 1,974,287 males born 1951-2015, of whom 2686 were diagnosed with TC before the age of 30.

Results: A history of TC in male relatives was significantly associated with a diagnosis of TC among children and young adults, including brothers (6. Read More

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http://dx.doi.org/10.1038/s41416-019-0445-2DOI Listing
April 2019
3 Reads

Mesothelium and Malignant Mesothelioma.

J Dev Biol 2019 Apr 8;7(2). Epub 2019 Apr 8.

Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA.

The mesothelium is an epithelial structure derived from the embryonic mesoderm. It plays an important role in the development of a number of different organs, including the heart, lungs, and intestines. In this publication, we discuss aspects of the development of the mesothelium, where mesothelial structures can be found, and review molecular and cellular characteristics associated with the mesothelium. Read More

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http://dx.doi.org/10.3390/jdb7020007DOI Listing
April 2019
1 Read

Extra-pleural pneumonectomy in the era of image-guided intensity-modulated radiotherapy.

Radiol Med 2019 Apr 8. Epub 2019 Apr 8.

Department of Radiation Oncology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Largo Brambilla, 3, 50134, Florence, Italy.

Purpose: To assess the outcome of malignant pleural mesothelioma patients treated with extra-pleural pneumonectomy (EPP) and adjuvant radiotherapy (RT), using the most advanced radiotherapeutic techniques, namely image-guided intensity-modulated RT (IG-IMRT).

Methods And Materials: Fifty-four patients were analyzed. Minimum radiation dose was 50 Gy (2 Gy/fr). Read More

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http://link.springer.com/10.1007/s11547-019-01030-y
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http://dx.doi.org/10.1007/s11547-019-01030-yDOI Listing
April 2019
4 Reads

Endobronchial ultrasound-guided transbronchial needle aspiration mediastinal lymph node staging in malignant pleural mesothelioma.

J Thorac Dis 2019 Feb;11(2):602-612

Division of Thoracic Surgery, Toronto General Hospital, University Health Network, ON, Canada.

Background: Given poor survival of patients with malignant pleural mesothelioma (MPM) and extrapleural nodal metastasis, pre-operative mediastinal lymph node (LN) staging has been advocated. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) may be a useful pre-operative adjunct in patients with MPM. This study aims to assess performance of EBUS-TBNA for mediastinal LN staging in MPM. Read More

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http://dx.doi.org/10.21037/jtd.2019.01.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409243PMC
February 2019
1 Read

Benign Pleural Mesothelial Cells Have Higher Osmotic Water Permeability than Malignant Pleural Mesothelioma Cells and Differentially Respond to Hyperosmolality.

Cell Physiol Biochem 2019 ;52(4):869-878

Department of Physiology, Faculty of Medicine, University of Thessaly, BIOPOLIS, Larissa, Greece.

Background/aims: Cell volume regulation is a critical mechanism for cell homeostasis and depends on the osmotic water permeability (P) of the cell plasma membrane. The P of human mesothelial cells is unknown although they contribute to serosal fluid turnover.

Methods: In this study we measured the osmotic water permeability of benign human mesothelial cells (MeT-5A) and of epithelioid (M14K) and sarcomatoid (ZL34) malignant pleural mesothelioma (MPM) cells in response to acute hyperosmotic stress. Read More

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http://dx.doi.org/10.33594/000000060DOI Listing
April 2019
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Cytoplasmic MTAP expression loss detected by immunohistochemistry correlates with 9p21 homozygous deletion detected by FISH in pleural effusion cytology of mesothelioma.

Histopathology 2019 Apr 8. Epub 2019 Apr 8.

Departments of Pathology, Fukuoka University Hospital and School of Medicine, Fukuoka, Japan.

Malignant pleural mesothelioma (MPM) is an aggressive neoplasm with poor prognosis. Diagnosis includes verification of mesothelial origin and discrimination of MPM from reactive mesothelial hyperplasia (RMH) or reactive mesothelial cells (RMC). This can be challenging. Read More

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http://dx.doi.org/10.1111/his.13872DOI Listing
April 2019
2 Reads

Incidence and survival of peritoneal malignant mesothelioma between 1989 and 2015: A population-based study.

Cancer Epidemiol 2019 Apr 3;60:106-111. Epub 2019 Apr 3.

INSERM U1086 « ANTICIPE », Caen University, F-14000, Caen, France; Occupational Diseases Department, University Hospital, Caen, F-14033, France.

Background: Peritoneal malignant mesothelioma is a rare disease for which few population-based studies are available. The aim of this study was to describe the evolution of the incidence and survival of peritoneal malignant mesothelioma in France between 1989 and 2015, using data derived from the French network of cancer registries.

Methods: Age world-standardized incidence rates and overall survival were calculated using data from 16 French cancer registries. Read More

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http://dx.doi.org/10.1016/j.canep.2019.03.014DOI Listing
April 2019
2 Reads

Survival analysis via nomogram of surgical patients with malignant pleural mesothelioma in the Surveillance, Epidemiology, and End Results database.

Thorac Cancer 2019 Apr 5. Epub 2019 Apr 5.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Thoracic Medical Oncology, Peking University Cancer Hospital & Institute, Beijing, China.

Background: Malignant pleural mesothelioma (MPM) is a rare but aggressive tumor that originates from the pleura and has a poor prognosis. Eligible patients can benefit from surgery, but their survival is affected by many factors. Therefore, we created a graphic model that could predict the prognosis of surgically treated patients. Read More

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http://dx.doi.org/10.1111/1759-7714.13063DOI Listing
April 2019
2 Reads

Prevention and Treatment of Peritoneal Metastases: a Comprehensive Review.

Indian J Surg Oncol 2019 Mar 3;10(1):3-23. Epub 2019 Jan 3.

Center for Gastrointestinal Malignancies, MedStar Washington Hospital Center, 106 Irving St., NW, Suite 3900, Washington, DC 20010 USA.

Peritoneal metastases may occur from a majority of cancers that occur within the abdomen or pelvis. When cancer spread to the peritoneal surfaces is documented, a decision regarding palliation versus an aggressive approach using cytoreductive surgery (CRS) and hyperthermic perioperative intraperitoneal chemotherapy (HIPEC) must be made. This decision is dependent on a well-defined group of prognostic indicators. Read More

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http://link.springer.com/10.1007/s13193-018-0856-1
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http://dx.doi.org/10.1007/s13193-018-0856-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414583PMC
March 2019
5 Reads

Diagnostic value of soluble mesothelin-related peptides in pleural effusion for malignant pleural mesothelioma: An updated meta-analysis.

Medicine (Baltimore) 2019 Apr;98(14):e14979

Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Background: Soluble mesothelin-related peptide (SMRP) is a widely studied tumor marker for diagnosing malignant pleural mesothelioma (MPM). This study discussed the diagnostic value of SMRPs in pleural effusion (PE) for MPM.

Methods: Medline, Embase, Web of Science, and Cochrane library system were systematically searched on the data of SMRPs in PE for MPM diagnosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014979DOI Listing
April 2019
1 Read
5.723 Impact Factor

A survey of patient and caregiver experience with malignant pleural mesothelioma.

Support Care Cancer 2019 Apr 3. Epub 2019 Apr 3.

Centre for Medical Psychology and Evidence-Based Decision-Making, The University of Sydney, Sydney, NSW, 2006, Australia.

Background: Malignant pleural mesothelioma (MPM) is a rare cancer with poor prognosis. As there is little information on the lived experience of MPM, our aim was to document the experience of MPM patients and their caregivers.

Methods: Surveys for MPM patients and caregivers were developed from previous interviews with patients, caregivers, and health professionals, about treatments and decision-making. Read More

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http://dx.doi.org/10.1007/s00520-019-04760-xDOI Listing
April 2019
4 Reads

Pseudomesotheliomatous Carcinoma with a High Pleural Hyaluronic Acid Concentration Arising from a Primary Esophageal Squamous Cell Carcinoma.

Am J Case Rep 2019 Apr 4;20:447-452. Epub 2019 Apr 4.

Department of Diagnostic Pathology, Japan Community Health Care Organization (JCHO) Saitama Medical Center, Saitama City, Saitama, Japan.

BACKGROUND Pseudomesotheliomatous carcinomas are rare tumors that develop like malignant pleural mesothelioma (MPM). These tumors have similar features, and thus pseudomesotheliomatous carcinomas can sometimes be misdiagnosed as MPM. Most pseudomesotheliomatous carcinomas develop from primary lung cancers, although there have been some reports involving other malignancies; however, there has been no report describing a pseudomesotheliomatous carcinoma developing from an esophageal squamous cell carcinoma (ESCC). Read More

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http://dx.doi.org/10.12659/AJCR.913782DOI Listing
April 2019
2 Reads

Droplet digital PCR as a novel system for the detection of microRNA‑34b/c methylation in circulating DNA in malignant pleural mesothelioma.

Int J Oncol 2019 Apr 1. Epub 2019 Apr 1.

Department of General Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan.

Malignant pleural mesothelioma (MPM) is a rare malignancy arising from the pleura that is difficult to diagnose, contributing to its dismal prognosis. Previously, we reported that the degree of microRNA (miR)‑34b/c methylation in circulating DNA is associated with the development of MPM. Herein, we present a newly developed droplet digital PCR (ddPCR)‑based assay for the detection of miR‑34b/c methylation in circulating DNA in patients with MPM. Read More

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http://dx.doi.org/10.3892/ijo.2019.4768DOI Listing
April 2019
2 Reads

The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.

Pathol Oncol Res 2019 Apr 2. Epub 2019 Apr 2.

Research Laboratories, Hull York Medical School, Daisy Building, Castle Hill Hospital, Hull, HU16 5JQ, UK.

Advanced malignant pleural mesothelioma (MPM) has an extremely poor prognosis with limited chemotherapy options, therefore the identification of new therapeutic targets would aid in disease management. Arachidonic acid is metabolised by cyclooxygenase and lipoxygenase enzymes. The lipoxygenase isoenzymes 5-LOX and 12-LOX have been implicated in carcinogenesis. Read More

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http://dx.doi.org/10.1007/s12253-019-00652-xDOI Listing
April 2019
3 Reads

Thoracic Hyper-IgG4-Related Disease Mimicking Malignant Pleural Mesothelioma.

Lung 2019 Apr 2. Epub 2019 Apr 2.

Unit of Thoracic Surgery, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

We report a rare case of a IgG4-related disease presenting with recurrent pleural effusion, pleural thickness and multiple mediastinal lymphadenopathies and no involvement of other extrathoracic organs. A 65-year-old man with a previous asbestos exposure presented with cough and pain discomfort. A large right pleural effusion was detected and evacuated (siero-haematic liquid). Read More

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http://link.springer.com/10.1007/s00408-019-00224-5
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http://dx.doi.org/10.1007/s00408-019-00224-5DOI Listing
April 2019
3 Reads

Bilateral diffuse pulmonary infiltrates secondary to malignant peritoneal mesothelioma - A rare clinical presentation.

Respir Med Case Rep 2019 4;26:326-327. Epub 2019 Mar 4.

Department of Respiratory Medicine, Royal Darwin Hospital, Darwin, NT, Australia.

Diffuse pulmonary metastasis secondary to primary peritoneal malignant mesothelioma is rarely reported in the literature. In this report we describe a 59-year-old Caucasian women with no known previous asbestos exposure presenting with bilateral diffuse pulmonary opacities in association with primary malignant peritoneal mesothelioma. The diagnosis was confirmed by ultrasound guided abdominal and bronchoscopy, -bronchial lung biopsy. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411511PMC
March 2019
1 Read

A case from India of pleural malignant mesothelioma probably due to domestic and environmental asbestos exposure: a posthumous report.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Community Medicine, All India Institute of Medical Sciences Jodphur, Jodhpur, Rajasthan, India.

India is the largest consumer of asbestos in the world. There is no report from India of mesothelioma related to asbestos. The case is a 42-year-old man who died of pleural mesothelioma. Read More

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http://dx.doi.org/10.1136/bcr-2018-227882DOI Listing
March 2019
2 Reads

The forensic significance of pseudomesotheliomatous adenocarcinoma of the lung.

Authors:
John M Kennedy

Forensic Sci Med Pathol 2019 Mar 30. Epub 2019 Mar 30.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

Pseudomesotheliomatous carcinomas (PMC) are rare tumors that clinically, macroscopically, and sometimes histologically resemble malignant pleural mesotheliomas. We report a case of a 91 year woman who was found to have diffuse nodular pleural thickening and a lung mass during a workup for persistent cough. She declined rapidly and died before a histologic diagnosis could be made. Read More

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http://dx.doi.org/10.1007/s12024-019-00110-9DOI Listing
March 2019
1 Read

A novel diagnostic method for distinguishing parapneumonic effusion and empyema from other diseases by using the pleural lactate dehydrogenase to adenosine deaminase ratio and carcinoembryonic antigen levels.

Medicine (Baltimore) 2019 Mar;98(13):e15003

Division of Allergy/Pulmonary/Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee.

Pleural effusions are a common medical problem not only for pulmonologists but also for general physicians, often needing thoracentesis for a definite diagnosis. However, thoracentesis cannot always reveal malignant cells or microbiological evidence.In this context, we prospectively enrolled a total of 289 patients with pleural effusions due to diverse etiologies: parapneumonic effusion (PPE) (63), empyema (22), tuberculous pleural effusion (TBPE) (54), malignant pleural effusion (MPE) (140), or chronic renal failure (CRF)/congestive heart failure (CHF) (10). Read More

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http://dx.doi.org/10.1097/MD.0000000000015003DOI Listing
March 2019
1 Read

Prophylactic Irradiation of Tracts in Patients With Malignant Pleural Mesothelioma: An Open-Label, Multicenter, Phase III Randomized Trial.

J Clin Oncol 2019 Mar 28:JCO1801678. Epub 2019 Mar 28.

1 The Christie National Health Service Foundation Trust, Manchester, United Kingdom.

Purpose: Prophylactic irradiation to the chest wall after diagnostic or therapeutic procedures in patients with malignant pleural mesothelioma (MPM) has been a widespread practice across Europe, although the efficacy of this treatment is uncertain. In this study, we aimed to determine the efficacy of prophylactic radiotherapy in reducing the incidence of chest wall metastases (CWM) after a procedure in MPM.

Methods: After undergoing a chest wall procedure, patients with MPM were randomly assigned to receive prophylactic radiotherapy (within 42 days of the procedure) or no radiotherapy. Read More

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http://dx.doi.org/10.1200/JCO.18.01678DOI Listing
March 2019
1 Read

Patterns of care and survival of older patients with malignant pleural mesothelioma.

J Geriatr Oncol 2019 Mar 24. Epub 2019 Mar 24.

University of Sydney, Sydney, Australia; Sydney Local Health District, Sydney, Australia.

Objective: Malignant pleural mesothelioma (MPM) is a cancer that primarily affects older adults. However this patient population is frequently under-represented in clinical studies. Therefore, we studied the impact of advancing age on treatment utilisation and clinical outcomes in an extensive series of minimally selected MPM patients. Read More

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http://dx.doi.org/10.1016/j.jgo.2019.02.013DOI Listing
March 2019
1 Read

Epidermal growth factor receptor (EGFR)-targeted therapies in mesothelioma.

Expert Opin Drug Deliv 2019 Mar 27:1-11. Epub 2019 Mar 27.

a Department of Medical Oncology , Austin Health , Melbourne , Australia.

Introduction: Malignant mesothelioma (MM) is an aggressive malignancy arising from the mesothelial cells lining the pleura and other serosal membranes. It is associated with an extremely poor prognosis and has limited therapeutic options. Areas covered: Epidermal growth factor receptor (EGFR) is known to be highly overexpressed in mesothelioma with reported EGFR overexpression between 44 to 97%. Read More

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http://dx.doi.org/10.1080/17425247.2019.1598374DOI Listing
March 2019
1 Read

Tomotherapy in malignant mesothelioma: a planning study to establish dose constraints.

Strahlenther Onkol 2019 Mar 26. Epub 2019 Mar 26.

Radiologische Klinik, FE Strahlentherapie, Universitätsklinik Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.

Purpose: A planning study was performed for helical tomotherapy treatment. We evaluated the maximum achievable protection of organs at risk (OARs) in patients with malignant pleural mesothelioma after pleurectomy with simultaneous optimal target coverage.

Materials And Methods: The datasets of 13 patients were included. Read More

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http://dx.doi.org/10.1007/s00066-019-01458-1DOI Listing
March 2019
3 Reads

Malignant Peritoneal Mesothelioma Mimicking Recurrent Diverticulitis.

Cureus 2019 Jan 17;11(1):e3906. Epub 2019 Jan 17.

Internal Medicine, University of Central Florida College of Medicine, Orlando, USA.

Mesothelioma is an uncommon type of cancer arising from the mesothelial cells that form the lining of several cavities in the body. Exposure to asbestos is the leading known cause of mesothelioma. We present a 73-year-old male with a significant asbestos exposure and a recent history of recurrent diverticulitis who reported persistent left lower quadrant (LLQ) pain despite several courses of empiric antibiotic therapy. Read More

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http://dx.doi.org/10.7759/cureus.3906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424585PMC
January 2019
1 Read

Prognostic Factors of Malignant Peritoneal Mesothelioma Experienced in Japanese Peritoneal Metastasis Center.

Gan To Kagaku Ryoho 2019 Feb;46(2):395-399

Japanese/Asian School of Peritoneal Surface Malignancy Treatment.

Background And Objectives: The current standard of treatment for malignant peritoneal mesothelioma(MPM)is cytoreductive surgery(CRS)plus perioperative intraperitoneal or systemic chemotherapy(comprehensive treatment), The present study was performed to clarify the prognostic factors of PMP after comprehensive treatment.

Methods: Among 63 patients with MPM, male and female patients were 34 and 29. CRSwas performed in 47 patients and complete cytoreduction(CC-0) was performed in 14(22%)patients. Read More

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February 2019
1 Read

Synchronous presentation of muscle-invasive urothelial carcinoma of bladder and peritoneal malign mesothelioma.

Int Braz J Urol 2019 Mar 22;45. Epub 2019 Mar 22.

Department of Urology, Istanbul Bilim University, Istanbul, Turkey.

Introduction: Cancer is one of the most important leading cause of death in man and woman in the world. The occurrence of new cancer has become more frequent in recent years due to strict screening protocols and occupational and environmental exposure to carcinogens. The incidence of secondary malignancies has also increased due to close medical follow-up and advanced age. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0815DOI Listing
March 2019
3 Reads

Intrapleural Urokinase Directly Under Medical Thoracoscopy for the Diagnosis of Malignant Pleural Mesothelioma With Severe Multiloculated Pleural Effusions.

J Bronchology Interv Pulmonol 2019 Apr;26(2):e26-e27

Department of Respiratory Medicine Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.

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http://dx.doi.org/10.1097/LBR.0000000000000576DOI Listing
April 2019
1 Read

Making cold malignant pleural effusions hot: driving novel immunotherapies.

Oncoimmunology 2019 22;8(4):e1554969. Epub 2019 Jan 22.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

Malignant pleural effusions, arising from either primary mesotheliomas or secondary malignancies, heralds advanced disease and poor prognosis. Current treatments, including therapeutic thoracentesis and tube thoracostomy, are largely palliative. The immunosuppressive environment within the pleural cavity includes myeloid derived suppressor cells, T-regulatory cells, and dysfunctional T cells. Read More

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http://dx.doi.org/10.1080/2162402X.2018.1554969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422374PMC
January 2019
1 Read

Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications.

Nat Commun 2019 03 22;10(1):1333. Epub 2019 Mar 22.

Centre de Recherche des Cordeliers, Sorbonne Universités, Inserm, UMRS-1138, 75006, Paris, France.

Malignant pleural mesothelioma (MPM) is recognized as heterogeneous based both on histology and molecular profiling. Histology addresses inter-tumor and intra-tumor heterogeneity in MPM and describes three major types: epithelioid, sarcomatoid and biphasic, a combination of the former two types. Molecular profiling studies have not addressed intra-tumor heterogeneity in MPM to date. Read More

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http://dx.doi.org/10.1038/s41467-019-09307-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430832PMC
March 2019
2 Reads

Malignant mesothelioma of tunica vaginalis without any risk factors: An uncommon case.

J Cancer Res Ther 2019 Mar;15(Supplement):S167-S169

Department of Urology, P.D. Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India.

Malignant mesothelioma (MM) of the tunica vaginalis (TV) is a rare tumor. It is seen in elderly patients, with painless scrotal swelling being the most common presentation. The exact etiology is unknown; a few risk factors have been suggested. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_1403_16DOI Listing
March 2019
1 Read

The influence of genetic variability of DNA repair mechanisms on the risk of malignant mesothelioma.

Radiol Oncol 2019 Mar 14. Epub 2019 Mar 14.

Clinical Institute of Occupational Medicine, University Medical Center Ljubljana, Ljubljana, Slovenia.

Background Malignant mesothelioma (MM) is a rare aggressive tumour of mesothelium caused by asbestos exposure. It has been suggested that the genetic variability of proteins involved in DNA repair mechanisms affects the risk of MM. This study investigated the influence of functional polymorphisms in ERCC1 and XRCC1 genes, the interactions between these polymorphisms as well as the interactions between these polymorphisms and asbestos exposure on MM risk. Read More

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http://content.sciendo.com/view/journals/raon/ahead-of-print
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http://dx.doi.org/10.2478/raon-2019-0016DOI Listing
March 2019
4 Reads

Correction: Malignant mesothelioma diagnosed at a younger age is associated with heavier asbestos exposure.

Carcinogenesis 2019 03 19. Epub 2019 Mar 19.

Department of Pathology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1093/carcin/bgz037DOI Listing
March 2019
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HMGB1 as a Potential Biomarker and Therapeutic Target for Malignant Mesothelioma.

Dis Markers 2019 12;2019:4183157. Epub 2019 Feb 12.

Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.

Malignant mesothelioma (MM) is a rare, aggressive, and highly lethal cancer that is substantially induced by exposure to asbestos fibers. High-mobility group box 1 (HMGB1) is an intriguing proinflammatory molecule involved in MM. In this review, we describe the possible crucial roles of HMGB1 in carcinogenic mechanisms based on and experimental evidence and outline the clinical findings of epidemiological investigations regarding the possible roles of HMGB1 as a biomarker for MM. Read More

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http://dx.doi.org/10.1155/2019/4183157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390248PMC
February 2019
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Mesothelioma subtypes of the tunica vaginalis: a rare case report and review of histological criteria.

J Surg Case Rep 2019 Mar 12;2019(3):rjz040. Epub 2019 Mar 12.

Urology Department, West Suffolk NHS Foundation Trust, Bury St. Edmunds, UK.

Well-differentiated papillary mesothelioma (WDPM) is a rare histological subtype of mesothelioma arising from the tunica vaginalis. We present a case of a 23-year-old male with a palpable para-testicular lump of 3 years duration. Scrotal exploration revealed a grossly abnormal cystic appearance of his tunica vaginalis. Read More

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http://dx.doi.org/10.1093/jscr/rjz040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413374PMC
March 2019
5 Reads

Body composition and nutritional status in malignant pleural mesothelioma: implications for activity levels and quality of life.

Eur J Clin Nutr 2019 Mar 18. Epub 2019 Mar 18.

Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.

Background/objectives: Malignant pleural mesothelioma (MPM) is an incurable cancer and optimizing daily physical activity and quality of life are key goals of patient management. Little is known about the prevalence of pre-sarcopenia and malnutrition in MPM or their associations with patient outcomes. This study aimed to determine the prevalence of pre-sarcopenia and malnutrition in MPM and investigate if activity levels and quality of life differed according to body composition and nutritional status. Read More

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http://dx.doi.org/10.1038/s41430-019-0418-9DOI Listing
March 2019
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The importance of FISH signal cut-off values for 9p21 deletion in malignant pleural mesothelioma: Is it underestimated?

Pathol Res Pract 2019 Mar 4. Epub 2019 Mar 4.

Department of Pathology, Faculty of Medicine, Gazi University, Turkey.

Malignant mesothelioma (MM) is an aggressive cancer with a poor prognosis. The most common genetic alteration in MM is the deletion of the INK4a/ARF locus, which encodes the p16 protein and is located on the short arm of chromosome 9 (9p21). Recently, it has been shown that homozygous deletion of 9p21 has both diagnostic and prognostic significance in MM. Read More

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http://dx.doi.org/10.1016/j.prp.2019.03.006DOI Listing
March 2019
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High BIN1 expression has a favorable prognosis in malignant pleural mesothelioma and is associated with tumor infiltrating lymphocytes.

Lung Cancer 2019 Apr 7;130:35-41. Epub 2019 Feb 7.

Sydney Medical School, The University of Sydney, Australia; Asbestos Diseases Research Institute, Sydney, NSW, Australia; Department of Medical Oncology, Chris O'Brien Lifehouse, Sydney, NSW, Australia.

Objectives: A number of key immune regulators show prognostic value in malignant pleural mesothelioma (MPM), but the association between Bridging integrator 1 (BIN1), indoleamine 2,3 dioxygenase 1 (IDO1) and patient outcome has not been investigated. We aimed to determine the expression of BIN1 and IDO1, their association with other markers and impact on overall survival (OS) in MPM.

Materials And Methods: The expression of BIN1, IDO1, CD3, CD20 and CD68 were evaluated by immunohistochemistry in 67 patients who underwent pleurectomy/decortication. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01695002193031
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http://dx.doi.org/10.1016/j.lungcan.2019.02.005DOI Listing
April 2019
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Highly expressed EZH2 in combination with BAP1 and MTAP loss, as detected by immunohistochemistry, is useful for differentiating malignant pleural mesothelioma from reactive mesothelial hyperplasia.

Lung Cancer 2019 Apr 27;130:187-193. Epub 2019 Feb 27.

Department of Pathology, Fukuoka University School of Medicine and Hospital, Fukuoka, Japan. Electronic address:

Objective: Malignant pleural mesothelioma (MPM) is an aggressive neoplasm with poor prognosis. Loss of BRCA-associated protein 1 (BAP1) protein expression as detected by immunohistochemistry (IHC) and homozygous deletion (HD) of the 9p21 locus as detected by fluorescence in situ hybridization (FISH) permits differentiation of MPM from reactive mesothelial hyperplasia (RMH). We have previously reported that detecting the loss of methylthioadenosine phosphorylase (MTAP) using IHC is a surrogate assay for 9p21 FISH. Read More

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http://dx.doi.org/10.1016/j.lungcan.2019.02.004DOI Listing
April 2019
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Exposure-Response Analysis of Overall Survival for Tremelimumab in Unresectable Malignant Mesothelioma: The Confounding Effect of Disease Status.

Clin Transl Sci 2019 Mar 18. Epub 2019 Mar 18.

MedImmune, Gaithersburg, Maryland, USA.

Tremelimumab, an anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody that enhances T-cell activation, was evaluated in a randomized, double-blind, placebo-controlled, phase IIb study (NCT01843374) in patients with unresectable malignant mesothelioma. The study demonstrated no clinically meaningful differences in overall survival (OS). The objective of this analysis was to evaluate the relationship of exposure with OS. Read More

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http://dx.doi.org/10.1111/cts.12633DOI Listing
March 2019
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Cryobiopsy during flex-rigid pleuroscopy: an emerging alternative biopsy method in malignant pleural mesothelioma. A comparative study of pathology.

Jpn J Clin Oncol 2019 Mar 18. Epub 2019 Mar 18.

Department of Pathology and Clinical Laboratories, Pathology Division, National Cancer Center Hospital, 5-1-1, Tsukiji Chou-ku, Tokyo 104-0045, Japan.

Background: Malignant pleural mesothelioma (MPM) is rarely an asbestos-related cancer with a poor prognosis that is difficult to distinguish from some benign conditions by using conventional biopsy techniques. The purpose of this study was to evaluate the utility of a novel biopsy technique using a cryoprobe during flex-rigid pleuroscopy for diagnosing MPM.

Methods: Consecutive patients who underwent pleural cryobiopsy during flex-rigid pleuroscopy from June through November 2017 to diagnose the cause of pleural effusion were collected. Read More

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http://dx.doi.org/10.1093/jjco/hyz032DOI Listing
March 2019
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Solid-liquid Interface Screening SystemーApplication to the Screening of Antibiotic and Cytotoxic Substance-producing Fungi.

Biocontrol Sci 2019 ;24(1):47-56

Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science andTechnology (AIST).

 A useful tool for the screening of fungi producing biologically active secondary metabolites such as antibiotics and cytotoxic substances has been developed. An agar plate-organic solvent interface cultivation (A/S-IFC) system, which comprised a hydrophobic organic solvent (upper phase) , a fungal mat (middle phase) and an agar plate (lower phase) , was constructed. The metabolite profiles were compared among the A/S-IFC, a traditional submerged cultivation (SmC) and an extractive liquid surface immobilization (Ext-LSI) system consisted of a hydrophobic solvent (upper phase) , a fungal cells-ballooned microspheres (middle phase) and a liquid medium (lower phase) , with high-performance liquid chromatography-photodiode array detector (HPLC-PDA) . Read More

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http://dx.doi.org/10.4265/bio.24.47DOI Listing
January 2019
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Localized multiple malignant epithelioid peritoneal mesotheliomas arising from the hepatoduodenal ligament and diaphragm: a case report.

J Med Case Rep 2019 Mar 18;13(1):66. Epub 2019 Mar 18.

Department of Gastroenterological Surgery, Division of Cancer Medicine Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, 920-8641, Japan.

Background: Malignant peritoneal mesothelioma is a rare aggressive tumor of the peritoneum. We report a rare case of resection of multiple localized malignant peritoneal mesotheliomas.

Case Presentation: A 55-year-old Japanese woman was admitted to our hospital because liver tumors were detected by abdominal ultrasonography during a screening examination. Read More

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http://dx.doi.org/10.1186/s13256-019-2008-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421649PMC
March 2019
1 Read