Search Our Scientific Publications & Authors

Invest New Drugs 2019 Apr 16. Epub 2019 Apr 16.

Indiana University Division of Hematology and Oncology, 535 Barnhill Dr, Indianapolis, IN, 46202, USA.

Purpose Brentuximab vedotin (BV) is an anti-CD30 antibody-drug conjugate used in the treatment of several types of lymphomas. Expression of the target antigen has also been reported on a variety of malignant tumors of nonlymphoid origin. This phase 2, open-label study evaluated the safety and antitumor activity of BV in patients with CD30-expressing nonlymphomatous malignancies. Read More

Int Arch Occup Environ Health 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Purpose: A 'risk reversal' has been observed for several human carcinogens following cessation of exposure, but it is unclear whether it also exists for asbestos-related mesothelioma.

Methods: We conducted a systematic review of the literature and identified nine studies that reported information on risk of mesothelioma after cessation of asbestos exposure, and performed a meta-regression based on random effects models. As comparison we analyzed results on lung cancer risk from four of these studies. Read More

Br J Cancer 2019 Apr 17. Epub 2019 Apr 17.

Sarah Cannon Research Institute, London, UK.

Background: Combined focal adhesion kinase (FAK) and MEK inhibition may provide greater anticancer effect than FAK monotherapy.

Methods: This dose-finding phase Ib study (adaptive 3 + 3 design) determined the maximum tolerated dose (MTD) of trametinib and the FAK inhibitor GSK2256098 in combination. Eligible patients had mesothelioma or other solid tumours with probable mitogen activated protein kinase pathway activation. Read More

Clin Lung Cancer 2019 Mar 26. Epub 2019 Mar 26.

Department of Radiation Oncology, New York Proton Center, New York, NY. Electronic address:

Background: Management options for unresected malignant pleural mesothelioma (MPM) are largely limited to palliative chemotherapy and best supportive care. This study sought to delineate subgroups most likely to benefit from chemotherapy.

Patients And Methods: The National Cancer Database was queried for newly-diagnosed unresected sarcomatoid, biphasic, and/or metastatic (M1) MPM. Read More

Medicine (Baltimore) 2019 Apr;98(15):e15147

Department of Pathology, The First Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning Province, China.

Rationale: Malignant mesothelioma is a malignant tumor with poor prognosis, which usually originates in the pleura, peritoneum, and pericardial cavity. Mesotheliomas that originate from the diaphragm are very rare. Here, we report a case of primary malignant mesothelioma of the diaphragm with liver invasion. Read More

Immunity 2019 Apr 5. Epub 2019 Apr 5.

Department of Systems Biology, Harvard Medical School, Boston, MA, USA. Electronic address:

Tumor-infiltrating myeloid cells (TIMs) comprise monocytes, macrophages, dendritic cells, and neutrophils, and have emerged as key regulators of cancer growth. These cells can diversify into a spectrum of states, which might promote or limit tumor outgrowth but remain poorly understood. Here, we used single-cell RNA sequencing (scRNA-seq) to map TIMs in non-small-cell lung cancer patients. Read More

Expert Rev Respir Med 2019 Apr 12. Epub 2019 Apr 12.

b Clinical Oncology Department , Ain Shams University , Cairo , Egypt .

Introduction: Trimodality therapy (including surgery, chemotherapy and radiation therapy) represents an important management approach of early-stage malignant pleural mesothelioma (MPM). The oncological value, as well as the proper sequence of the three modalities, is still under investigations. Areas Covered: The article covers the timing of chemotherapy in the management plan either "neoadjuvant approach" or in the adjuvant setting. Read More

Proc Natl Acad Sci U S A 2019 Apr 11. Epub 2019 Apr 11.

Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637.

Survival from malignant mesothelioma, particularly pleural mesothelioma, is very poor. For patients with breast, ovarian, or prostate cancers, overall survival is associated with increased sensitivity to platinum chemotherapy due to loss-of-function mutations in DNA repair genes. The goal of this project was to evaluate, in patients with malignant mesothelioma, the relationship between inherited loss-of-function mutations in DNA repair and other tumor suppressor genes and overall survival following platinum chemotherapy. Read More

Ann Ist Super Sanita 2019 Jan-Mar;55(1):70-79

Dipartimento Ambiente e Salute, Istituto Superiore di Sanità, Rome, Italy - WHO Collaborating Centre for Environmental Health in Contaminated Sites, Istituto Superiore di Sanità,Rome, Italy.

Introduction: Numerous municipalities in Italy currently experience asbestos health impact, in particular excesses of pleural mesothelioma incidence and mortality. This paper presents an integrated analysis of epidemiological studies and communication actions in affected municipalities to highlight how communication has been implemented depending on health impact evidence and involvement of local stakeholders.

Methodology: Four case studies are identified concerning industrial and natural sources of asbestos exposure having different diseases burden. Read More

Br J Cancer 2019 Apr 10. Epub 2019 Apr 10.

Institute of Health and Society, University of Oslo, P.O Box 1130 Blindervn, 0318, Oslo, Norway.

Background: The aim of this study was to examine the association of a family history of cancer with the risk of testicular cancer in young adults.

Methods: This is a prospective cohort study including 1,974,287 males born 1951-2015, of whom 2686 were diagnosed with TC before the age of 30.

Results: A history of TC in male relatives was significantly associated with a diagnosis of TC among children and young adults, including brothers (6. Read More

J Dev Biol 2019 Apr 8;7(2). Epub 2019 Apr 8.

Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA.

The mesothelium is an epithelial structure derived from the embryonic mesoderm. It plays an important role in the development of a number of different organs, including the heart, lungs, and intestines. In this publication, we discuss aspects of the development of the mesothelium, where mesothelial structures can be found, and review molecular and cellular characteristics associated with the mesothelium. Read More

Radiol Med 2019 Apr 8. Epub 2019 Apr 8.

Department of Radiation Oncology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Largo Brambilla, 3, 50134, Florence, Italy.

Purpose: To assess the outcome of malignant pleural mesothelioma patients treated with extra-pleural pneumonectomy (EPP) and adjuvant radiotherapy (RT), using the most advanced radiotherapeutic techniques, namely image-guided intensity-modulated RT (IG-IMRT).

Methods And Materials: Fifty-four patients were analyzed. Minimum radiation dose was 50 Gy (2 Gy/fr). Read More

J Thorac Dis 2019 Feb;11(2):602-612

Division of Thoracic Surgery, Toronto General Hospital, University Health Network, ON, Canada.

Background: Given poor survival of patients with malignant pleural mesothelioma (MPM) and extrapleural nodal metastasis, pre-operative mediastinal lymph node (LN) staging has been advocated. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) may be a useful pre-operative adjunct in patients with MPM. This study aims to assess performance of EBUS-TBNA for mediastinal LN staging in MPM. Read More

Cell Physiol Biochem 2019 ;52(4):869-878

Department of Physiology, Faculty of Medicine, University of Thessaly, BIOPOLIS, Larissa, Greece.

Background/aims: Cell volume regulation is a critical mechanism for cell homeostasis and depends on the osmotic water permeability (P) of the cell plasma membrane. The P of human mesothelial cells is unknown although they contribute to serosal fluid turnover.

Methods: In this study we measured the osmotic water permeability of benign human mesothelial cells (MeT-5A) and of epithelioid (M14K) and sarcomatoid (ZL34) malignant pleural mesothelioma (MPM) cells in response to acute hyperosmotic stress. Read More

Histopathology 2019 Apr 8. Epub 2019 Apr 8.

Departments of Pathology, Fukuoka University Hospital and School of Medicine, Fukuoka, Japan.

Malignant pleural mesothelioma (MPM) is an aggressive neoplasm with poor prognosis. Diagnosis includes verification of mesothelial origin and discrimination of MPM from reactive mesothelial hyperplasia (RMH) or reactive mesothelial cells (RMC). This can be challenging. Read More

Med Clin North Am 2019 May 7;103(3):535-548. Epub 2019 Mar 7.

Division of Environmental and Occupational Health Sciences, National Jewish Health, 1400 Jackson Street, G212, Denver, CO 80206, USA; Division of Pulmonary and Critical Care Sciences, Environmental Occupational Health Department, School of Medicine, Colorado School of Public Health, University of Colorado, Denver, CO, USA. Electronic address:

Occupational exposures are a major cause of lung disease and disability worldwide. This article reviews the broad range of types of occupational lung diseases, including airways disease, pneumoconioses, and cancer. Common causes of occupational lung disease are reviewed with specific examples and clinical features. Read More

Eur J Surg Oncol 2019 Mar 23. Epub 2019 Mar 23.

Department of Surgery, Peritoneal Surface Malignancy Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori di Milano, Via Giacomo Venezian 1, Milano, Milan Cap, 20133, Italy. Electronic address:

Pseudomyxoma Peritonei (PMP) and Peritoneal Mesothelioma (PM) are both rare peritoneal malignancies. Currently, affected patients may be treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy offering long-term survival or even cure in selected patients. However, many issues regarding the optimal treatment strategy are currently under debate. Read More

Cancer Epidemiol 2019 Apr 3;60:106-111. Epub 2019 Apr 3.

INSERM U1086 « ANTICIPE », Caen University, F-14000, Caen, France; Occupational Diseases Department, University Hospital, Caen, F-14033, France.

Background: Peritoneal malignant mesothelioma is a rare disease for which few population-based studies are available. The aim of this study was to describe the evolution of the incidence and survival of peritoneal malignant mesothelioma in France between 1989 and 2015, using data derived from the French network of cancer registries.

Methods: Age world-standardized incidence rates and overall survival were calculated using data from 16 French cancer registries. Read More

Cancer Res 2019 Apr 5. Epub 2019 Apr 5.

Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy

Targeting microenvironmental factors that foster migratory cell phenotypes is a promising strategy for halting tumor migration. However, lack of mechanistic understanding of the emergence of migratory phenotypes impedes pharmaceutical drug development. Using our 3D microtumor model with tight control over tumor size, we recapitulated the tumor size-induced hypoxic microenvironment and emergence of migratory phenotypes in microtumors from epithelial breast cells and patient-derived primary metastatic breast cancer cells, mesothelioma cells, and lung cancer xenograft cells (PDX). Read More

Thorac Cancer 2019 Apr 5. Epub 2019 Apr 5.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Thoracic Medical Oncology, Peking University Cancer Hospital & Institute, Beijing, China.

Background: Malignant pleural mesothelioma (MPM) is a rare but aggressive tumor that originates from the pleura and has a poor prognosis. Eligible patients can benefit from surgery, but their survival is affected by many factors. Therefore, we created a graphic model that could predict the prognosis of surgically treated patients. Read More

Occup Med (Lond) 2019 Apr;69(2):118-125

Health and Safety Executive, Harpur Hill, Buxton, Derbyshire, UK.

Background: The Health and Safety Executive's new Health and Work Strategy is based on an up-to-date assessment of workplace health priorities. Rather than replicating traditional prioritization approaches, a broader assessment of health and work priorities was carried out using a range of stakeholders.

Aims: To develop a set of health priorities for further research and intervention activity. Read More

Indian J Surg Oncol 2019 Mar 3;10(1):3-23. Epub 2019 Jan 3.

Center for Gastrointestinal Malignancies, MedStar Washington Hospital Center, 106 Irving St., NW, Suite 3900, Washington, DC 20010 USA.

Peritoneal metastases may occur from a majority of cancers that occur within the abdomen or pelvis. When cancer spread to the peritoneal surfaces is documented, a decision regarding palliation versus an aggressive approach using cytoreductive surgery (CRS) and hyperthermic perioperative intraperitoneal chemotherapy (HIPEC) must be made. This decision is dependent on a well-defined group of prognostic indicators. Read More

Toxicol Appl Pharmacol 2019 Apr 1;371:1-2. Epub 2019 Apr 1.

Department of Family and Community Medicine, University of Toronto, 336 Spadina Road, Suite 902, Toronto, Ontario M5R 2V8, Canada; Department of Family Medicine, McMaster University, 336 Spadina Road, Suite 902, Toronto, Ontario M5R 2V8, Canada. Electronic address:

Dr. Garabrant presented a paper concerning a comparison of asbestos fiber potency and elongate mineral particle (EMP) potency for mesothelioma in humans at the Elongate Mineral Particles Conference in Charlottesville, Virginia in 2017. I was a participant at the Conference. Read More

Medicine (Baltimore) 2019 Apr;98(14):e14979

Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Background: Soluble mesothelin-related peptide (SMRP) is a widely studied tumor marker for diagnosing malignant pleural mesothelioma (MPM). This study discussed the diagnostic value of SMRPs in pleural effusion (PE) for MPM.

Methods: Medline, Embase, Web of Science, and Cochrane library system were systematically searched on the data of SMRPs in PE for MPM diagnosis. Read More

Support Care Cancer 2019 Apr 3. Epub 2019 Apr 3.

Centre for Medical Psychology and Evidence-Based Decision-Making, The University of Sydney, Sydney, NSW, 2006, Australia.

Background: Malignant pleural mesothelioma (MPM) is a rare cancer with poor prognosis. As there is little information on the lived experience of MPM, our aim was to document the experience of MPM patients and their caregivers.

Methods: Surveys for MPM patients and caregivers were developed from previous interviews with patients, caregivers, and health professionals, about treatments and decision-making. Read More

Am J Case Rep 2019 Apr 4;20:447-452. Epub 2019 Apr 4.

Department of Diagnostic Pathology, Japan Community Health Care Organization (JCHO) Saitama Medical Center, Saitama City, Saitama, Japan.

BACKGROUND Pseudomesotheliomatous carcinomas are rare tumors that develop like malignant pleural mesothelioma (MPM). These tumors have similar features, and thus pseudomesotheliomatous carcinomas can sometimes be misdiagnosed as MPM. Most pseudomesotheliomatous carcinomas develop from primary lung cancers, although there have been some reports involving other malignancies; however, there has been no report describing a pseudomesotheliomatous carcinoma developing from an esophageal squamous cell carcinoma (ESCC). Read More

Int J Oncol 2019 Apr 1. Epub 2019 Apr 1.

Department of General Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan.

Malignant pleural mesothelioma (MPM) is a rare malignancy arising from the pleura that is difficult to diagnose, contributing to its dismal prognosis. Previously, we reported that the degree of microRNA (miR)‑34b/c methylation in circulating DNA is associated with the development of MPM. Herein, we present a newly developed droplet digital PCR (ddPCR)‑based assay for the detection of miR‑34b/c methylation in circulating DNA in patients with MPM. Read More

J BUON 2019 Jan-Feb;24(1):391-396

Euromedica Kyanous Stavros, Thessaloniki, Greece.

Purpose: Peritoneal mesothelioma is a rare disease that remains confined to the peritoneal surfaces for long. Cytoreductive surgery (CRS) combined with hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) is the most effective treatment and complete cytoreduction is the most significant prognostic indicator of long-term survival. This study attempted to present the results of CRS in combination with hyperthermic intraperitoneal chemotherapy in patients with peritoneal mesothelioma and identify the prognostic indicators of survival. Read More

Pathol Oncol Res 2019 Apr 2. Epub 2019 Apr 2.

Research Laboratories, Hull York Medical School, Daisy Building, Castle Hill Hospital, Hull, HU16 5JQ, UK.

Advanced malignant pleural mesothelioma (MPM) has an extremely poor prognosis with limited chemotherapy options, therefore the identification of new therapeutic targets would aid in disease management. Arachidonic acid is metabolised by cyclooxygenase and lipoxygenase enzymes. The lipoxygenase isoenzymes 5-LOX and 12-LOX have been implicated in carcinogenesis. Read More

Lung 2019 Apr 2. Epub 2019 Apr 2.

Unit of Thoracic Surgery, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

We report a rare case of a IgG4-related disease presenting with recurrent pleural effusion, pleural thickness and multiple mediastinal lymphadenopathies and no involvement of other extrathoracic organs. A 65-year-old man with a previous asbestos exposure presented with cough and pain discomfort. A large right pleural effusion was detected and evacuated (siero-haematic liquid). Read More

Respir Med Case Rep 2019 4;26:326-327. Epub 2019 Mar 4.

Department of Respiratory Medicine, Royal Darwin Hospital, Darwin, NT, Australia.

Diffuse pulmonary metastasis secondary to primary peritoneal malignant mesothelioma is rarely reported in the literature. In this report we describe a 59-year-old Caucasian women with no known previous asbestos exposure presenting with bilateral diffuse pulmonary opacities in association with primary malignant peritoneal mesothelioma. The diagnosis was confirmed by ultrasound guided abdominal and bronchoscopy, -bronchial lung biopsy. Read More

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Community Medicine, All India Institute of Medical Sciences Jodphur, Jodhpur, Rajasthan, India.

India is the largest consumer of asbestos in the world. There is no report from India of mesothelioma related to asbestos. The case is a 42-year-old man who died of pleural mesothelioma. Read More

Occup Environ Med 2019 May 30;76(5):356. Epub 2019 Mar 30.

Centre for Child Health Research, University of Western Australia, Crawley, Western Australia, Australia.

Am J Epidemiol 2019 Mar 30. Epub 2019 Mar 30.

Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland.

We extended the mortality follow-up of a cohort of 25,460 workers employed at eight acrylonitrile (AN)-producing facilities in the United States by 21 years. Based on 8,124 deaths and 1,023,922 person-years of follow-up, we evaluated the relationship between occupational AN exposure and mortality. Standardized mortality ratios (SMR) based on deaths through December 31, 2011 were calculated. Read More

Pathol Oncol Res 2019 Mar 29. Epub 2019 Mar 29.

Dental Research Center, Dentistry Research Institute, Department of Oral Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

All different types of metabolism of tumors are dependent on the flow of water molecules through the biological membrane, where fluid transfer interceded by aquaporins (AQPs) are the basis means for water entrance into the cells or outside them. Aquaporins play other roles including cellular migration, cellular expansion and cellular adhesion facilitation. Therefore, regulators of AQPs may be useful anticancer agents. Read More

Forensic Sci Med Pathol 2019 Mar 30. Epub 2019 Mar 30.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

Pseudomesotheliomatous carcinomas (PMC) are rare tumors that clinically, macroscopically, and sometimes histologically resemble malignant pleural mesotheliomas. We report a case of a 91 year woman who was found to have diffuse nodular pleural thickening and a lung mass during a workup for persistent cough. She declined rapidly and died before a histologic diagnosis could be made. Read More

Insights Imaging 2019 Mar 29;10(1):42. Epub 2019 Mar 29.

Department of Radiology, School of Medicine, Hacettepe University, 06100, Ankara, Turkey.

The pericardium could be involved in a variety of clinical disorders. The imaging findings are not specific for an individual pathology in most of the cases; however, patient's clinical history may guide radiologist to a definitive diagnosis. Congenital absence of the pericardium could be recognized with the imaging appearance of interposed lung tissue between the main pulmonary artery and aorta. Read More

Ann Glob Health 2019 Mar 29;85(1). Epub 2019 Mar 29.

Department of Environment and Health, Istituto Superiore di Sanità, Rome, IT.

Background: Asbestos consumption in Latin America (LA) amounts to 10% of yearly global production. Little is known about the impact of asbestos exposure in the region.

Objective: To discuss scientific and socio-economic issues and conflicts of interest and to summarize epidemiological data of asbestos health effects in LA. Read More

Medicine (Baltimore) 2019 Mar;98(13):e15003

Division of Allergy/Pulmonary/Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee.

Pleural effusions are a common medical problem not only for pulmonologists but also for general physicians, often needing thoracentesis for a definite diagnosis. However, thoracentesis cannot always reveal malignant cells or microbiological evidence.In this context, we prospectively enrolled a total of 289 patients with pleural effusions due to diverse etiologies: parapneumonic effusion (PPE) (63), empyema (22), tuberculous pleural effusion (TBPE) (54), malignant pleural effusion (MPE) (140), or chronic renal failure (CRF)/congestive heart failure (CHF) (10). Read More

J Clin Oncol 2019 Mar 28:JCO1801678. Epub 2019 Mar 28.

1 The Christie National Health Service Foundation Trust, Manchester, United Kingdom.

Purpose: Prophylactic irradiation to the chest wall after diagnostic or therapeutic procedures in patients with malignant pleural mesothelioma (MPM) has been a widespread practice across Europe, although the efficacy of this treatment is uncertain. In this study, we aimed to determine the efficacy of prophylactic radiotherapy in reducing the incidence of chest wall metastases (CWM) after a procedure in MPM.

Methods: After undergoing a chest wall procedure, patients with MPM were randomly assigned to receive prophylactic radiotherapy (within 42 days of the procedure) or no radiotherapy. Read More

J Geriatr Oncol 2019 Mar 24. Epub 2019 Mar 24.

University of Sydney, Sydney, Australia; Sydney Local Health District, Sydney, Australia.

Objective: Malignant pleural mesothelioma (MPM) is a cancer that primarily affects older adults. However this patient population is frequently under-represented in clinical studies. Therefore, we studied the impact of advancing age on treatment utilisation and clinical outcomes in an extensive series of minimally selected MPM patients. Read More

Expert Opin Drug Deliv 2019 Mar 27. Epub 2019 Mar 27.

a Department of Medical Oncology , Austin Health , Melbourne , Australia.

Introduction: Malignant mesothelioma (MM) is an aggressive malignancy arising from the mesothelial cells lining the pleura and other serosal membranes. It is associated with an extremely poor prognosis and has limited therapeutic options. Areas covered: Epidermal growth factor receptor (EGFR) is known to be highly over-expressed in mesothelioma with reported EGFR overexpression between 44 to 97%. Read More

Tumori 2019 Mar 27:300891619839305. Epub 2019 Mar 27.

2 Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.

Purpose:: To assess whether asbestos fibers may be observed in liver tissue of patients with cholangiocarcinoma (CC) with environmental or working asbestos exposure.

Methods:: Detection of fibers was performed directly on histologic sections of liver from 7 patients with CC using optical microscope and variable pressure scanning electron microscopy equipped with energy-dispersive spectroscopy (VP-SEM/EDS). All patients were from Casale Monferrato, Italy, a highly asbestos-polluted town. Read More

Strahlenther Onkol 2019 Mar 26. Epub 2019 Mar 26.

Radiologische Klinik, FE Strahlentherapie, Universitätsklinik Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.

Purpose: A planning study was performed for helical tomotherapy treatment. We evaluated the maximum achievable protection of organs at risk (OARs) in patients with malignant pleural mesothelioma after pleurectomy with simultaneous optimal target coverage.

Materials And Methods: The datasets of 13 patients were included. Read More

Cureus 2019 Jan 17;11(1):e3906. Epub 2019 Jan 17.

Internal Medicine, University of Central Florida College of Medicine, Orlando, USA.

Mesothelioma is an uncommon type of cancer arising from the mesothelial cells that form the lining of several cavities in the body. Exposure to asbestos is the leading known cause of mesothelioma. We present a 73-year-old male with a significant asbestos exposure and a recent history of recurrent diverticulitis who reported persistent left lower quadrant (LLQ) pain despite several courses of empiric antibiotic therapy. Read More

Gan To Kagaku Ryoho 2019 Feb;46(2):395-399

Japanese/Asian School of Peritoneal Surface Malignancy Treatment.

Background And Objectives: The current standard of treatment for malignant peritoneal mesothelioma(MPM)is cytoreductive surgery(CRS)plus perioperative intraperitoneal or systemic chemotherapy(comprehensive treatment), The present study was performed to clarify the prognostic factors of PMP after comprehensive treatment.

Methods: Among 63 patients with MPM, male and female patients were 34 and 29. CRSwas performed in 47 patients and complete cytoreduction(CC-0) was performed in 14(22%)patients. Read More

Genome Med 2019 03 26;11(1):18. Epub 2019 Mar 26.

Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

As trials of immune checkpoint inhibitor (ICI) therapies demonstrate responses in only a minority of pleural mesotheliomas (PlMs) and largely exclude patients with the related peritoneal mesothelioma (PeM), clinicians need predictive biomarkers of response and inclusion of PeM patients in future trials. A new study finds that loss of the deubiquitinase BAP1 in PeM correlates with an inflammatory tumor microenvironment, suggesting that BAP1 status might identify PeM, and possibly PlM, patients who would benefit from ICI therapy. Read More

Int Braz J Urol 2019 Mar 22;45. Epub 2019 Mar 22.

Department of Urology, Istanbul Bilim University, Istanbul, Turkey.

Introduction: Cancer is one of the most important leading cause of death in man and woman in the world. The occurrence of new cancer has become more frequent in recent years due to strict screening protocols and occupational and environmental exposure to carcinogens. The incidence of secondary malignancies has also increased due to close medical follow-up and advanced age. Read More

Pleura Peritoneum 2018 Dec 18;3(4):20180124. Epub 2018 Dec 18.

Paris Diderot University, Sorbonne Paris Cité, CART, INSERM U965, Paris, France.

Background: The aim of this review was to analyze preclinical studies and clinical trials evaluating photodynamic therapy (PDT), and photothermal therapy (PTT) in peritoneal metastasis (PM) treatment.

Content: Systematic review according PRISMA guidelines. Electronic searches using PubMed and Clinical Trials. Read More