177 results match your criteria Mesoblastic Nephroma Imaging


Imaging of Neo-angiogenesis of Transplanted Metastases in Subrenal Capsule Assay Induced Rat Model.

In Vivo 2022 Jul-Aug;36(4):1667-1675

Division of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, Debrecen, Hungary;

Background/aim: Changes in the expression of neo-angiogenic molecules in the primary tumor and its metastases may significantly affect the efficacy of therapies. The aim of this study was to evaluate the alterations in aminopeptidase N (APN/CD13) and αβ integrin receptor expression in serially transplanted mesoblastic nephroma tumor (Ne/De) metastases using Gallium (Ga)-labeled NOTA-cNGR and NODAGA-RGD radiotracers and preclinical positron emission tomography (PET) imaging.

Materials And Methods: Primary and metastatic mesoblastic nephroma (Ne/De) tumors were induced by subrenal capsule assay (SRCA) in Fischer-344 rats. Read More

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Cellular congenital mesoblastic nephroma detected by prenatal MRI: a case report and literature review.

Transl Pediatr 2022 Jan;11(1):163-173

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.

Congenital mesoblastic nephroma (CMN) is a rare tumor, yet it is the most frequently diagnosed renal neoplasm in the first 3 months of life. CMN reports with prenatal magnetic resonance imaging (MRI) are scarce. Our aims were to describe a case with fetal MR imaging along with other findings, and to review the literature concerned with prenatal MRI detection of CMN. Read More

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January 2022

Imaging of Prenatal and Neonatal Intra-abdominal Genitourinary Tumors: a Review of the Literature.

Curr Urol Rep 2022 Mar 15;23(3):39-46. Epub 2022 Feb 15.

Department of Urology, OHSU Doernbecher Children's Hospital, Oregon Health & Science University, 700 S.W. Campus Drive, Portland, OR, 97239, USA.

Purpose Of Review: Our goal was to summarize current literature related to imaging of intra-abdominal genitourinary tumors diagnosed in the prenatal or neonatal period. Our specific interests included modalities used, diagnoses made, changing incidence of tumor detection, and proposed future uses of these imaging modalities.

Recent Findings: Fetal and neonatal MRI have been used as an adjunct to ultrasound for better characterization and assessment of congenital mesoblastic nephroma, juvenile granulosa cell tumor, and other tumors. Read More

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Infantile fibrosarcoma with an EGFR kinase domain duplication: Underlining a close relationship with congenital mesoblastic nephroma and highlighting a similar morphological spectrum.

Ann Diagn Pathol 2022 Apr 3;57:151885. Epub 2022 Jan 3.

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands. Electronic address:

Infantile fibrosarcoma (IFS) and congenital mesoblastic nephroma (CMN) are locally aggressive tumors primarily occurring in infants. Both IFS and the cellular subtype of CMN show overlapping morphological features and an ETV6-NTRK3 fusion, suggesting a close relationship. An activating alteration of EGFR, based on an EGFR kinase domain duplication (KDD), occurs in a subset of CMNs lacking an NTRK3 rearrangement, especially in the classic and mixed type. Read More

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Prenatal Diagnosis of Fetal Congenital Mesoblastic Nephroma and Neonatal Follow-up.

J Med Ultrasound 2021 Apr-Jun;29(2):126-128. Epub 2020 Oct 1.

Department of Obstetrics and Gynecology, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan.

We describe a case of fetal congenital mesoblastic nephroma (CMN) who was diagnosed with ultrasound at 32 weeks of gestation; after delivery, the neonate received left radical nephrectomy, and pathology report confirmed the diagnosis. All cross-sectional imaging studies, such as ultrasonography, computed tomography (CT) scanning, and magnetic resonance imaging, may help to define the organ of origin and the relationship to the ipsilateral kidney. To our knowledge, this is the first case of fetal CMN who was diagnosed in the third trimester and then with a live-born baby in Taiwan. Read More

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October 2020

[Imaging of renal tumors in children].

Radiologe 2021 Jul 18;61(7):619-628. Epub 2021 Jun 18.

Klinik für Pädiatrische Onkologie und Hämatologie, Universitätskinderklinik, Universitätsklinikum des Saarlandes, Homburg, Deutschland.

Clinical/methodological Issue: Renal tumors in children are treated according to the guidelines of the Renal Tumor Study Group of the International Society of Pediatric Oncology (SIOP-RTSG). Nephroblastoma is the most frequent renal tumor in children.

Standard Radiological Methods: After sonography, magnetic resonance imaging (MRI) is the preferred imaging modality. Read More

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Prenatal diagnosis and postnatal management of congenital mesoblastic nephroma: Experience at a single center in China.

Prenat Diagn 2021 May 5;41(6):766-771. Epub 2021 Apr 5.

Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China.

Objective: To review the prenatal and postnatal clinical characteristics and pathological subtypes, as well as the surgical outcome for congenital mesoblastic nephroma (CMN) cases.

Method: A retrospective review was performed in 11 cases with CMN prenatally diagnosed at a single center between 2015 and 2019. The clinical characteristics, surgical outcome, histopathology, and follow-up were retrospectively obtained and reviewed. Read More

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Diagnostic accuracy and cytomorphological spectrum of Wilms tumour in fine needle aspiration biopsy cytology samples supplemented with cell blocks.

Pediatr Blood Cancer 2021 07 21;68(7):e28996. Epub 2021 Mar 21.

Department of Cytology and Gynaecological Pathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Objective: Paediatric malignant renal neoplasms are subjected to neoadjuvant chemotherapy as per Societe Internationale d'Oncologie Pediatrique; International Society of Pediatric Oncology (SIOP) protocol. An accurate tissue diagnosis is required prior to institution of chemotherapy, and hence the aim of this study was to evaluate the diagnostic accuracy of fine needle aspiration biopsy cytology (FNABC) along with cell block histology.

Materials And Methods: A retrospective audit of all paediatric renal neoplasms diagnosed by FNABC between 2015 and 2019 was performed. Read More

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Neonatal Renal Tumors.

Authors:
Sei-Gyung K Sze

Clin Perinatol 2021 03 11;48(1):71-81. Epub 2021 Jan 11.

Maine Children's Cancer Program, Department of Pediatrics, Maine Medical Center, Tufts School of Medicine, 100 Campus Drive, Suite 107, Scarborough, ME 04074, USA. Electronic address:

Renal tumors are rare in the neonatal period. Although some may be detected prenatally, a greater proportion present after birth, most often with a palpable abdominal mass with or without other associated symptoms. Cross-sectional imaging is typically followed by radical nephrectomy to make a specific histologic diagnosis to determine the need for additional therapy. Read More

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Prenatal diagnosis of fetal congenital mesoblastic nephroma by ultrasonography combined with MR imaging: A case report and literature review.

Medicine (Baltimore) 2021 Jan;100(3):e24034

Department of Center for Reproductive Medicine and Center for Prenatal Diagnosis, The First Hospital of Jilin University, Changchun, Jilin, P.R. China.

Rationale: Fetal congenital mesoblastic nephroma (CMN) is a rare renal tumor, characterized by polyhydramnios, premature birth, and neonatal hypertension. In the prenatal stage, it is particularly difficult to diagnose CMN either by ultrasonography or magnetic resonance imaging (MRI). Thus, CMN is frequently detected in the third trimester in the clinical scenario. Read More

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January 2021

Imaging of solid congenital abdominal masses: a review of the literature and practical approach to image interpretation.

Pediatr Radiol 2020 12 30;50(13):1907-1920. Epub 2020 Nov 30.

Department of Radiology, Pediatric Section, Baylor Scott and White Health-Temple, McLane Children's Medical Center, Texas A&M Health Science Center, 2401 S. 31st St., MS-01-W256, Temple, TX, 76508, USA.

Fetal abdominal tumors are rare, usually benign, and cause a great deal of anxiety for expectant parents and the physicians counseling them. In this paper the author reviews the most common fetal abdominal tumors in the liver (hemangioma, mesenchymal hamartoma, hepatoblastoma, metastases) and the kidney (congenital mesoblastic nephroma, Wilms tumor, malignant rhabdoid tumor, and clear cell sarcoma), and suprarenal mass lesions (adrenal neuroblastoma, adrenal hemorrhage, and subdiaphragmatic extralobar pulmonary sequestration). The author describes the imaging approach, imaging appearance and differentiating features of tumors, and differences between fetal and childhood appearances of tumors. Read More

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December 2020

Imaging manifestations of congenital mesoblastic nephroma.

Clin Imaging 2021 Apr 4;72:91-96. Epub 2020 Nov 4.

Department of Radiology, Qingdao Women and Children's Hospital, Qingdao, Shandong, 266000, China; Shandong Key Laboratory of Digital Medicine and Computer Assisted Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China. Electronic address:

Objective: Congenital mesoblastic nephroma (CMN) is a rare renal tumor mainly observed in infants and young children. This study aims to analyze the imaging manifestations of CMN to improve the understanding of the disease.

Methods: The imaging manifestations and clinical records of all pediatric patients with CMN admitted to our hospital over the last 7 years were retrospectively analyzed. Read More

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Expanding Phenotype of Schimke Immuno-Osseous Dysplasia: Congenital Anomalies of the Kidneys and of the Urinary Tract and Alteration of NK Cells.

Int J Mol Sci 2020 Nov 15;21(22). Epub 2020 Nov 15.

"Lalla Seràgnoli", Hematology-Oncology Unit, Department of Pediatrics, University of Bologna, 40138 Bologna, Italy.

Schimke immuno-osseous dysplasia (SIOD) is a rare multisystemic disorder with a variable clinical expressivity caused by biallelic variants in . A phenotype-genotype correlation has been attempted and variable expressivity of biallelic variants may be associated with environmental and genetic disturbances of gene expression. We describe two siblings born from consanguineous parents with a diagnosis of SIOD revealed by whole exome sequencing (WES). Read More

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November 2020

Papers presented at the fall 2020 Pediatric Urologic Oncology Work Group of the Societies of Pediatric Urology meetingPrenatally Diagnosed Solid Renal Mass.

Urology 2021 07 13;153:317-319. Epub 2020 Nov 13.

Department of Urology, UC Irvine and Children's Hospital of Orange County, Orange, CA.

Congenital mesoblastic nephroma is the most common renal neoplasm diagnosed in the first month of life of which 15% occur prenatally. We present a prenatal diagnosis of a 5.8 cm solid renal mass identified on the 36-week ultrasound. Read More

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A single centre matched pair series comparing minimally invasive and open surgery for the resection of pediatric renal tumours.

Surg Oncol 2020 Dec 24;35:498-503. Epub 2020 Oct 24.

Department of Paediatric Surgery and Urology, Birmingham Children's Hospital, UK. Electronic address:

Introduction: Minimally invasive nephrectomy (MIN)for the resection of pediatric renal tumors is controversial. We compared patients who underwent laparoscopic MIN according to our unit protocol with matched patients who underwent open surgery (ON).

Method: A single centre retrospective analysis of prospectively collected data for MIN. Read More

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December 2020

In vivo assessment of aminopeptidase N (APN/CD13) specificity of different Ga-labelled NGR derivatives using PET/MRI imaging.

Int J Pharm 2020 Nov 16;589:119881. Epub 2020 Sep 16.

Division of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, Hungary; Doctoral School of Clinical Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, Hungary; Gyula Petrányi Doctoral School of Allergy and Clinical Immunology, Faculty of Medicine, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, Hungary. Electronic address:

Aminopeptidase N (APN/CD13) plays an important role in neoangiogenic process in malignancies. Our previous studies have already shown that Ga-labelled NOTA conjugated asparagine-glycine-arginine peptide (c[KNGRE]-NH) specifically bind to APN/CD13 expressing tumors. The aim of this study was to evaluate and compare the APN/CD13 specificity of newly synthesized Ga-labelled NGR derivatives in vivo by PET/MRI imaging using hepatocellular carcinoma (He/De) and mesoblastic nephroma (Ne/De) tumor models. Read More

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November 2020

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.

Nat Commun 2020 03 11;11(1):1310. Epub 2020 Mar 11.

Oncode Institute, Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.

Kidney tumours are among the most common solid tumours in children, comprising distinct subtypes differing in many aspects, including cell-of-origin, genetics, and pathology. Pre-clinical cell models capturing the disease heterogeneity are currently lacking. Here, we describe the first paediatric cancer organoid biobank. Read More

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Imaging of fetal tumors and other dysplastic lesions: A review with emphasis on MR imaging.

Prenat Diagn 2020 01;40(1):84-99

Surgery Department Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Fetal tumors and other dysplastic masses are relatively rare. They are usually the result of failure of differentiation and maturation during embryonic or fetal life; dysplastic lesions may be the consequence of an obstruction sequence. In this review, we present the most commonly encountered tumors and masses seen during fetal life. Read More

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January 2020

Prenatal diagnosis of congenital mesoblastic nephroma: a case with poor prognosis.

BMJ Case Rep 2019 Aug 28;12(8). Epub 2019 Aug 28.

Gynecology-Obstetrics, Hospital Garcia de Orta EPE, Almada, Portugal.

Congenital mesoblastic nephromais a rare tumour found in neonates, with a very small number of cases diagnosed prenatally. We report a case of a fetal renal tumour suspected at 28 weeks' gestation on routine ultrasound. Prenatal follow-up revealed a severe polyhydramnios at 32 weeks' gestation subsequent amniodrainage was undertaken. Read More

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Unusual Case of Concurrent Retroperitoneal Congenital Infantile Fibrosarcoma and Cellular Type Congenital Mesoblastic Nephroma.

J Pediatr Hematol Oncol 2020 11;42(8):e801-e806

Department of Pediatrics, Division of Hematology/Oncology.

Background: Although congenital infantile fibrosarcoma (cIFS) is a rare soft tissue sarcoma among children, it constitutes one of the most common soft tissue sarcomas during the first year of life. Congenital mesoblastic nephroma (CMN) is the most common benign renal tumor usually developing during the first 3 months of life. cIFS and cellular type CMN (cCMN) share not only similar histopathologic features but identical molecular genetic abnormality including the ETV6/NTRK3 fusion gene. Read More

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November 2020

The clinical presentation, imaging features and differential diagnoses of congenital Wilms tumour.

BMJ Case Rep 2019 May 30;12(5). Epub 2019 May 30.

Radiology Department, San Fernando General Hospital, San Fernando, Trinidad and Tobago.

Solid fetal renal masses are a rare finding on antenatal ultrasound, with hydronephrosis and cystic disease of the kidney usually being the most common causes for fetal renal enlargement. Herein we report a case of a solid fetal renal mass which was detected on third trimester antenatal ultrasound scanning. This renal mass was evaluated by MRI in the postnatal period and diagnosis confirmed by histological analysis, after surgical excision. Read More

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Cellular mesoblastic nephroma in infants and children: Report of four cases and review of the literature.

Urologia 2020 May 23;87(2):91-96. Epub 2019 May 23.

Department of Pediatric Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Cellular mesoblastic nephroma is rare after infancy, and there are many controversial reports about its clinical presentation and treatment as well as outcome in infants, young children, and adolescents.

Objectives: In this report, we will discuss our experience with four cases of cellular mesoblastic nephroma presented from infancy to childhood (from 18 months of age to 11 years of age).

Cases: During 10 years, we had the experience of 4 cases of pediatric renal tumor with the diagnosis of cellular mesoblastic nephroma, which have been followed between 1 year and 6 years. Read More

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Pediatric Renal Neoplasms:: MR Imaging-Based Practical Diagnostic Approach.

Magn Reson Imaging Clin N Am 2019 May;27(2):279-290

Department of Radiology, Seattle Children's, University of Washington, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA.

Pediatric renal tumors may be malignant or benign. Wilms tumor, the most common malignant pediatric renal tumor, arises sporadically or with various syndromes. Renal cell carcinoma typically presents in older children. Read More

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Congenital Mesoblastic Nephroma Presenting with Hematuria in a Neonate.

J Nippon Med Sch 2018 ;85(5):297-299

Department of Radiology, Shandong Provincial Hospital affiliated to Shandong University.

Congenital mesoblastic nephroma (CMN) is a rare tumor of infancy. CMNs can be histologically divided into classic, cellular, and mixed subtypes. Cellular CMNs are difficult to differentiate from Wilms tumors. Read More

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February 2019

Specific computed tomography imaging characteristics of congenital mesoblastic nephroma and correlation with ultrasound and pathology.

J Pediatr Urol 2018 12 1;14(6):571.e1-571.e6. Epub 2018 Aug 1.

Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, 58th, The Second Zhongshan Road, Guanzhou, China. Electronic address:

Introduction: Congenital mesoblastic nephroma (CMN) is a common solid renal tumor in the neonate. Congenital mesoblastic nephroma can be divided into classic, cellular, and mixed types. The prognosis of CMN is very optimistic. Read More

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December 2018

Dramatic bone remodeling following larotrectinib administration for bone metastasis in a patient with TRK fusion congenital mesoblastic nephroma.

Pediatr Blood Cancer 2018 10 12;65(10):e27271. Epub 2018 Jun 12.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Mesoblastic nephroma is the most frequent renal tumor in newborns and young infants, and the cellular type is characterized by an ETV6-NTRK fusion, which constitutively activates the tropomyosin-related kinase (TRK) signaling pathway. Larotrectinib is a highly selective TRK inhibitor with activity in adult and pediatric patients who have TRK fusions. We present a rare case of a patient with mesoblastic nephroma metastatic to bone who had a dramatic response to larotrectinib. Read More

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October 2018

Fetal biparametric MR imaging in the diagnosis of congenital mesoblastic nephroma.

Turk J Urol 2018 May 1;44(3):278-280. Epub 2018 May 1.

Department of Surgical and Biomedical Sciences, Division of Radiology 2, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy.

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[Mesenchymal abdominal tumors in children].

Authors:
G A Krombach

Radiologe 2018 Jan;58(1):3-9

Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Giessen, Justus-Liebig Universität Giessen, Klinikstraße 33, 35392, Giessen, Deutschland.

Mesenchymal tumors in childhood comprise benign and malign entities and differ regarding typical sites of manifestation, age peak and clinical symptoms. In some cases biopsy is mandatory. If nephroblastoma is a possible diagnosis, biopsy must be avoided by all means in order to avoid biopsy tract metastasis. Read More

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January 2018

Unusual Presentation of Metanephric Stromal Tumor in a Neonate.

Indian J Med Paediatr Oncol 2017 Jul-Sep;38(3):357-359

Department of Paediatric Surgery, LTMG Hospital, Mumbai, Maharashtra, India.

Metanephric stromal tumor (MST) of kidney is an under-reported benign stromal specific renal neoplasm with good prognosis. This tumor is to be differentiated from congenital mesoblastic nephroma and clear-cell sarcoma of the kidney. In this case report, we describe the imaging, gross, and microscopic features of MST with ischemic left kidney in a 1-month-old child and discuss treatment with relevant literature. Read More

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December 2017

Imagistic and histopathological description of a cystic nephroma during early second trimester of gestation. Case report.

Med Ultrason 2016 Dec;19(3):327-329

IMOGEN, Centre of Advanced Research Studies, Cluj-Napoca, Romania.

Cystic nephroma is a rare and benign renal tumour of unknown origin, usually diagnosed in the first years of childhood or during adult life. To our knowledge, there are no records in the literature of this particular tumour being descried prenatally. We present a case of a fetus diagnosed with cystic nephroma on 16 weeks of gestation. Read More

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December 2016