169 results match your criteria Mesoblastic Nephroma Imaging


Diagnostic accuracy and cytomorphological spectrum of Wilms tumour in fine needle aspiration biopsy cytology samples supplemented with cell blocks.

Pediatr Blood Cancer 2021 Jul 21;68(7):e28996. Epub 2021 Mar 21.

Department of Cytology and Gynaecological Pathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Objective: Paediatric malignant renal neoplasms are subjected to neoadjuvant chemotherapy as per Societe Internationale d'Oncologie Pediatrique; International Society of Pediatric Oncology (SIOP) protocol. An accurate tissue diagnosis is required prior to institution of chemotherapy, and hence the aim of this study was to evaluate the diagnostic accuracy of fine needle aspiration biopsy cytology (FNABC) along with cell block histology.

Materials And Methods: A retrospective audit of all paediatric renal neoplasms diagnosed by FNABC between 2015 and 2019 was performed. Read More

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Neonatal Renal Tumors.

Authors:
Sei-Gyung K Sze

Clin Perinatol 2021 03 11;48(1):71-81. Epub 2021 Jan 11.

Maine Children's Cancer Program, Department of Pediatrics, Maine Medical Center, Tufts School of Medicine, 100 Campus Drive, Suite 107, Scarborough, ME 04074, USA. Electronic address:

Renal tumors are rare in the neonatal period. Although some may be detected prenatally, a greater proportion present after birth, most often with a palpable abdominal mass with or without other associated symptoms. Cross-sectional imaging is typically followed by radical nephrectomy to make a specific histologic diagnosis to determine the need for additional therapy. Read More

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Prenatal diagnosis of fetal congenital mesoblastic nephroma by ultrasonography combined with MR imaging: A case report and literature review.

Medicine (Baltimore) 2021 Jan;100(3):e24034

Department of Center for Reproductive Medicine and Center for Prenatal Diagnosis, The First Hospital of Jilin University, Changchun, Jilin, P.R. China.

Rationale: Fetal congenital mesoblastic nephroma (CMN) is a rare renal tumor, characterized by polyhydramnios, premature birth, and neonatal hypertension. In the prenatal stage, it is particularly difficult to diagnose CMN either by ultrasonography or magnetic resonance imaging (MRI). Thus, CMN is frequently detected in the third trimester in the clinical scenario. Read More

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January 2021

Imaging of solid congenital abdominal masses: a review of the literature and practical approach to image interpretation.

Pediatr Radiol 2020 12 30;50(13):1907-1920. Epub 2020 Nov 30.

Department of Radiology, Pediatric Section, Baylor Scott and White Health-Temple, McLane Children's Medical Center, Texas A&M Health Science Center, 2401 S. 31st St., MS-01-W256, Temple, TX, 76508, USA.

Fetal abdominal tumors are rare, usually benign, and cause a great deal of anxiety for expectant parents and the physicians counseling them. In this paper the author reviews the most common fetal abdominal tumors in the liver (hemangioma, mesenchymal hamartoma, hepatoblastoma, metastases) and the kidney (congenital mesoblastic nephroma, Wilms tumor, malignant rhabdoid tumor, and clear cell sarcoma), and suprarenal mass lesions (adrenal neuroblastoma, adrenal hemorrhage, and subdiaphragmatic extralobar pulmonary sequestration). The author describes the imaging approach, imaging appearance and differentiating features of tumors, and differences between fetal and childhood appearances of tumors. Read More

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December 2020

Imaging manifestations of congenital mesoblastic nephroma.

Clin Imaging 2021 Apr 4;72:91-96. Epub 2020 Nov 4.

Department of Radiology, Qingdao Women and Children's Hospital, Qingdao, Shandong, 266000, China; Shandong Key Laboratory of Digital Medicine and Computer Assisted Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China. Electronic address:

Objective: Congenital mesoblastic nephroma (CMN) is a rare renal tumor mainly observed in infants and young children. This study aims to analyze the imaging manifestations of CMN to improve the understanding of the disease.

Methods: The imaging manifestations and clinical records of all pediatric patients with CMN admitted to our hospital over the last 7 years were retrospectively analyzed. Read More

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Expanding Phenotype of Schimke Immuno-Osseous Dysplasia: Congenital Anomalies of the Kidneys and of the Urinary Tract and Alteration of NK Cells.

Int J Mol Sci 2020 Nov 15;21(22). Epub 2020 Nov 15.

"Lalla Seràgnoli", Hematology-Oncology Unit, Department of Pediatrics, University of Bologna, 40138 Bologna, Italy.

Schimke immuno-osseous dysplasia (SIOD) is a rare multisystemic disorder with a variable clinical expressivity caused by biallelic variants in . A phenotype-genotype correlation has been attempted and variable expressivity of biallelic variants may be associated with environmental and genetic disturbances of gene expression. We describe two siblings born from consanguineous parents with a diagnosis of SIOD revealed by whole exome sequencing (WES). Read More

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November 2020

A single centre matched pair series comparing minimally invasive and open surgery for the resection of pediatric renal tumours.

Surg Oncol 2020 Dec 24;35:498-503. Epub 2020 Oct 24.

Department of Paediatric Surgery and Urology, Birmingham Children's Hospital, UK. Electronic address:

Introduction: Minimally invasive nephrectomy (MIN)for the resection of pediatric renal tumors is controversial. We compared patients who underwent laparoscopic MIN according to our unit protocol with matched patients who underwent open surgery (ON).

Method: A single centre retrospective analysis of prospectively collected data for MIN. Read More

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December 2020

In vivo assessment of aminopeptidase N (APN/CD13) specificity of different Ga-labelled NGR derivatives using PET/MRI imaging.

Int J Pharm 2020 Nov 16;589:119881. Epub 2020 Sep 16.

Division of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, Hungary; Doctoral School of Clinical Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, Hungary; Gyula Petrányi Doctoral School of Allergy and Clinical Immunology, Faculty of Medicine, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, Hungary. Electronic address:

Aminopeptidase N (APN/CD13) plays an important role in neoangiogenic process in malignancies. Our previous studies have already shown that Ga-labelled NOTA conjugated asparagine-glycine-arginine peptide (c[KNGRE]-NH) specifically bind to APN/CD13 expressing tumors. The aim of this study was to evaluate and compare the APN/CD13 specificity of newly synthesized Ga-labelled NGR derivatives in vivo by PET/MRI imaging using hepatocellular carcinoma (He/De) and mesoblastic nephroma (Ne/De) tumor models. Read More

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November 2020

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.

Nat Commun 2020 03 11;11(1):1310. Epub 2020 Mar 11.

Oncode Institute, Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.

Kidney tumours are among the most common solid tumours in children, comprising distinct subtypes differing in many aspects, including cell-of-origin, genetics, and pathology. Pre-clinical cell models capturing the disease heterogeneity are currently lacking. Here, we describe the first paediatric cancer organoid biobank. Read More

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Imaging of fetal tumors and other dysplastic lesions: A review with emphasis on MR imaging.

Prenat Diagn 2020 01;40(1):84-99

Surgery Department Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Fetal tumors and other dysplastic masses are relatively rare. They are usually the result of failure of differentiation and maturation during embryonic or fetal life; dysplastic lesions may be the consequence of an obstruction sequence. In this review, we present the most commonly encountered tumors and masses seen during fetal life. Read More

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January 2020

Prenatal diagnosis of congenital mesoblastic nephroma: a case with poor prognosis.

BMJ Case Rep 2019 Aug 28;12(8). Epub 2019 Aug 28.

Gynecology-Obstetrics, Hospital Garcia de Orta EPE, Almada, Portugal.

Congenital mesoblastic nephromais a rare tumour found in neonates, with a very small number of cases diagnosed prenatally. We report a case of a fetal renal tumour suspected at 28 weeks' gestation on routine ultrasound. Prenatal follow-up revealed a severe polyhydramnios at 32 weeks' gestation subsequent amniodrainage was undertaken. Read More

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Unusual Case of Concurrent Retroperitoneal Congenital Infantile Fibrosarcoma and Cellular Type Congenital Mesoblastic Nephroma.

J Pediatr Hematol Oncol 2020 11;42(8):e801-e806

Department of Pediatrics, Division of Hematology/Oncology.

Background: Although congenital infantile fibrosarcoma (cIFS) is a rare soft tissue sarcoma among children, it constitutes one of the most common soft tissue sarcomas during the first year of life. Congenital mesoblastic nephroma (CMN) is the most common benign renal tumor usually developing during the first 3 months of life. cIFS and cellular type CMN (cCMN) share not only similar histopathologic features but identical molecular genetic abnormality including the ETV6/NTRK3 fusion gene. Read More

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November 2020

The clinical presentation, imaging features and differential diagnoses of congenital Wilms tumour.

BMJ Case Rep 2019 May 30;12(5). Epub 2019 May 30.

Radiology Department, San Fernando General Hospital, San Fernando, Trinidad and Tobago.

Solid fetal renal masses are a rare finding on antenatal ultrasound, with hydronephrosis and cystic disease of the kidney usually being the most common causes for fetal renal enlargement. Herein we report a case of a solid fetal renal mass which was detected on third trimester antenatal ultrasound scanning. This renal mass was evaluated by MRI in the postnatal period and diagnosis confirmed by histological analysis, after surgical excision. Read More

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Cellular mesoblastic nephroma in infants and children: Report of four cases and review of the literature.

Urologia 2020 May 23;87(2):91-96. Epub 2019 May 23.

Department of Pediatric Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Cellular mesoblastic nephroma is rare after infancy, and there are many controversial reports about its clinical presentation and treatment as well as outcome in infants, young children, and adolescents.

Objectives: In this report, we will discuss our experience with four cases of cellular mesoblastic nephroma presented from infancy to childhood (from 18 months of age to 11 years of age).

Cases: During 10 years, we had the experience of 4 cases of pediatric renal tumor with the diagnosis of cellular mesoblastic nephroma, which have been followed between 1 year and 6 years. Read More

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Pediatric Renal Neoplasms:: MR Imaging-Based Practical Diagnostic Approach.

Magn Reson Imaging Clin N Am 2019 May;27(2):279-290

Department of Radiology, Seattle Children's, University of Washington, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA.

Pediatric renal tumors may be malignant or benign. Wilms tumor, the most common malignant pediatric renal tumor, arises sporadically or with various syndromes. Renal cell carcinoma typically presents in older children. Read More

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Congenital Mesoblastic Nephroma Presenting with Hematuria in a Neonate.

J Nippon Med Sch 2018 ;85(5):297-299

Department of Radiology, Shandong Provincial Hospital affiliated to Shandong University.

Congenital mesoblastic nephroma (CMN) is a rare tumor of infancy. CMNs can be histologically divided into classic, cellular, and mixed subtypes. Cellular CMNs are difficult to differentiate from Wilms tumors. Read More

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February 2019

Specific computed tomography imaging characteristics of congenital mesoblastic nephroma and correlation with ultrasound and pathology.

J Pediatr Urol 2018 12 1;14(6):571.e1-571.e6. Epub 2018 Aug 1.

Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, 58th, The Second Zhongshan Road, Guanzhou, China. Electronic address:

Introduction: Congenital mesoblastic nephroma (CMN) is a common solid renal tumor in the neonate. Congenital mesoblastic nephroma can be divided into classic, cellular, and mixed types. The prognosis of CMN is very optimistic. Read More

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December 2018

Dramatic bone remodeling following larotrectinib administration for bone metastasis in a patient with TRK fusion congenital mesoblastic nephroma.

Pediatr Blood Cancer 2018 10 12;65(10):e27271. Epub 2018 Jun 12.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Mesoblastic nephroma is the most frequent renal tumor in newborns and young infants, and the cellular type is characterized by an ETV6-NTRK fusion, which constitutively activates the tropomyosin-related kinase (TRK) signaling pathway. Larotrectinib is a highly selective TRK inhibitor with activity in adult and pediatric patients who have TRK fusions. We present a rare case of a patient with mesoblastic nephroma metastatic to bone who had a dramatic response to larotrectinib. Read More

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October 2018

Fetal biparametric MR imaging in the diagnosis of congenital mesoblastic nephroma.

Turk J Urol 2018 May 1;44(3):278-280. Epub 2018 May 1.

Department of Surgical and Biomedical Sciences, Division of Radiology 2, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy.

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[Mesenchymal abdominal tumors in children].

Authors:
G A Krombach

Radiologe 2018 Jan;58(1):3-9

Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Giessen, Justus-Liebig Universität Giessen, Klinikstraße 33, 35392, Giessen, Deutschland.

Mesenchymal tumors in childhood comprise benign and malign entities and differ regarding typical sites of manifestation, age peak and clinical symptoms. In some cases biopsy is mandatory. If nephroblastoma is a possible diagnosis, biopsy must be avoided by all means in order to avoid biopsy tract metastasis. Read More

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January 2018

Unusual Presentation of Metanephric Stromal Tumor in a Neonate.

Indian J Med Paediatr Oncol 2017 Jul-Sep;38(3):357-359

Department of Paediatric Surgery, LTMG Hospital, Mumbai, Maharashtra, India.

Metanephric stromal tumor (MST) of kidney is an under-reported benign stromal specific renal neoplasm with good prognosis. This tumor is to be differentiated from congenital mesoblastic nephroma and clear-cell sarcoma of the kidney. In this case report, we describe the imaging, gross, and microscopic features of MST with ischemic left kidney in a 1-month-old child and discuss treatment with relevant literature. Read More

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December 2017

Imagistic and histopathological description of a cystic nephroma during early second trimester of gestation. Case report.

Med Ultrason 2016 Dec;19(3):327-329

IMOGEN, Centre of Advanced Research Studies, Cluj-Napoca, Romania.

Cystic nephroma is a rare and benign renal tumour of unknown origin, usually diagnosed in the first years of childhood or during adult life. To our knowledge, there are no records in the literature of this particular tumour being descried prenatally. We present a case of a fetus diagnosed with cystic nephroma on 16 weeks of gestation. Read More

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December 2016

Bi-parametric magnetic resonance imaging applied to obstetrics.

J Obstet Gynaecol 2017 Jul 17;37(5):670-672. Epub 2017 Mar 17.

d Santa Maria del Carmine Hospital , Provincial Health Care Services, Institute of Pathology , Rovereto , Italy.

Foetal magnetic resonance imaging (MRI) plays an increasingly important role in the diagnosis of foetal abnormalities. Over the years, we have successfully applied bi-parametric MRI (bp-MRI) to the following obstetric conditions: (1) neurologic vascular diseases; (2) assessment of lung parenchyma maturation; (3) renal pathologies, such as polycystic kidney, suspected renal infarction, unilateral or bilateral renal agenesis; (4) placental pathologies, as twin-twin transfusion syndrome or placenta accreta; (5) benignant and malignant congenital tumours or cysts of the liver, such as haemangioendothelioma, hepatoblastoma or metastatic neuroblastoma, of the kidney (e.g. Read More

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Management of mixed type congenital mesoblastic nephroma: Case series and review of the literature.

J Neonatal Perinatal Med 2017 ;10(1):113-118

Department of Pediatrics, Division of Neonatology, College of Medicine, Univeristy of Kentucky, Lexington, KY, USA.

Congenital mesoblastic nephroma (CMN) is the most common renal tumor of infancy; however, it occurs infrequently with an incidence of 1 : 125,000. The cellular and classical variants are the most common subtypes of tumors, with a mixed variant occurring infrequently. We describe two cases of mixed variant CMN, which presented within days of each other differing in their clinical behavior. Read More

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October 2017

Cytological diagnosis of mesoblastic nephroma: A report of three cases with summary of prior published cases.

Diagn Cytopathol 2016 Oct 21;44(10):823-7. Epub 2016 Jun 21.

Department of Pathology, IPGME&R, Kolkata, India.

Congenital mesoblastic nephroma (CMN) is a rare pediatric renal neoplasm, occurring most commonly in the first few months of life, with a favourable clinical outcome. Accurate pre-operative cytological diagnosis of this entity is important as pre-operative chemotherapy is not recommended and surgery is the treatment of choice. Cytodiagnosis of this rare tumor is discussed in only a few case reports. Read More

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October 2016

Uncommon renal tumors in children: A single center experience.

J Indian Assoc Pediatr Surg 2016 Apr-Jun;21(2):61-5

Department of Paediatric Surgery, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India.

Aims: Scrutiny over the clinical behaviors, management, and the final outcome of some rare renal neoplasm in order to find out some hidden facts about these tumors which are playing an important role in the disease course and its management.

Materials And Methods: Retrospective evaluation of uncommon (non-Wilms') renal neoplasm in the pediatric population in a tertiary care center. Fifteen cases of uncommon renal tumors were treated in our institution over the last 5 years (January 2008 to December 2012). Read More

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Renal Tumors of Childhood: Radiologic-Pathologic Correlation Part 1. The 1st Decade: From the Radiologic Pathology Archives.

Radiographics 2016 Mar-Apr;36(2):499-522

From the Department of Radiology and Radiological Sciences (E.M.C.), F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences (A.R.G.), 4301 Jones Bridge Rd, Bethesda, MD 20814; Pediatric Radiology Section, American Institute for Radiologic Pathology, Silver Spring, Md (E.M.C.); and Department of Pathology, Eastern Virginia Medical School, Norfolk, Va (R.M.C.).

Wilms tumor is the second most common pediatric solid tumor and by far the most common renal tumor of infants and young children. As most tumors are large at presentation and are treated with nephrectomy, the role of imaging is primarily in preoperative planning and evaluation for metastatic disease. However, with treatment protocols increasingly involving use of preoperative (neoadjuvant) chemotherapy (the standard in Europe) and consideration of nephron-sparing surgery, the role of imaging is evolving to include providing initial disease staging information and a presumptive diagnosis to guide therapy. Read More

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January 2017

Growing Renal Mass: Lessons Learned on the Road From an Atypical Presentation to Successful Therapy.

Urol Case Rep 2015 Sep 26;3(5):157-60. Epub 2015 Jun 26.

Division of Urology, The Children's Hospital of Philadelphia, Philadelphia, USA.

A 25 4/7 week boy was born with a prenatal diagnosis of polyhydramnios and enlarged left kidney. Over the next 2 months serial ultrasounds demonstrated abnormal growth of the kidney, with 28.9% split function. Read More

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September 2015

Congenital Mesoblastic Nephroma Presenting With Hematuria in a Neonate: A Case Report.

Urology 2016 Feb 23;88:189-91. Epub 2015 Nov 23.

Department of Paediatric Surgery and Urology, Children's Hospital at Westmead, Sydney, New South Wales, Australia; Discipline of Paediatrics & Child Health, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

Congenital mesoblastic nephroma (CMN) is the most frequent renal neoplasm of newborns and young infants. Four cases presenting with hemorrhagic manifestations have been reported in the English literature (Hu et al, 2006; Bolande et al, 1967). We report the unusual clinical and radiographic findings of a 2-day-old neonate with hematuria secondary to a CMN. Read More

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February 2016

Congenital mesoblastic nephroma: Its diverse clinical features - A literature review with a case report.

J Obstet Gynaecol 2016 14;36(3):340-4. Epub 2015 Oct 14.

a Department of Obstetrics and Gynecology , Jichi Medical University , Tochigi , Japan.

To characterise congenital mesoblastic nephroma (CMN), with special emphasis on polyhydramnios and the neonatal prognosis, we summarise 31 CMN patients (30 reported patients and the present patient). CMN was detected at a median of 30 weeks' gestation, and infants were delivered at a median of 34 weeks' gestation. Of 27 patients with available data, 19 (70%) had polyhydramnios, of which 8 required amnio- drainage. Read More

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January 2017