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Arterioscler Thromb Vasc Biol 2020 Jul 2:ATVBAHA120314491. Epub 2020 Jul 2.

From the Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University of Mainz (JGU), Germany (S.A., E.W., G.P., H.F., F.B., M.M., F.M., A.G., M.B., M.S., I.B., K.G., K.K., K.J., C.R.).

Objective: Recruitment of neutrophils and formation of neutrophil extracellular traps (NETs) contribute to lethality in acute mesenteric infarction. To study the impact of the gut microbiota in acute mesenteric infarction, we used gnotobiotic mouse models to study whether gut commensals prime the reactivity of neutrophils towards NETosis. Approach and Results: We applied a mesenteric ischemia-reperfusion (I/R) injury model to germ-free (GF) and colonized C57BL/6J mice. Read More

Langenbecks Arch Surg 2020 Jun 30. Epub 2020 Jun 30.

Department for Visceral, Thoracic and Vascular Surgery, Triemli Hospital Zurich, Zurich, Switzerland.

Purpose: Vascular encasement or infiltration of the portomesenteric veins can compromise resectability and local tumour control in pancreatic resections. So far, there is no consensus on how vascular reconstruction should be performed. Bovine pericardium has shown promising results, particularly in infected arterial vascular reconstructions. Read More

Toxins (Basel) 2020 Jun 28;12(7). Epub 2020 Jun 28.

Department of Medicine, Mackay Medical College, New Taipei City 25245, Taiwan.

Polymer polyethylene glycol (PEG), or PEGylation of polypeptides improves protein drug stability by decrease degradation and reduces renal clearance. To produce a pharmaceutical disintegrin derivative, the N-terminal PEGylation technique was used to modify the disintegrin derivative [KGDRR]trimucrin for favorable safety and pharmacokinetic profiles and antithrombotic efficacy. We compared intact [KGDRR]trimucrin (RR) and PEGylated KGDRR (PEG-RR) by in vitro and in vivo systems for their antithrombotic activities. Read More

Cureus 2020 May 26;12(5):e8303. Epub 2020 May 26.

Clinical Gastroenterology & Internal Medicine, Merit Health Rankin & William Carey University College of Osteopathic Medicine, Brandon, USA.

Buerger's disease is a type of vasculitis that predominantly affects small to medium arteries and the veins of the upper and lower extremities. Intestinal vessels are rarely involved. This is a case report of a 38-year-old male, smoker, with known Buerger's disease who was found to have ischemic colitis of the sigmoid colon on biopsy and inferior mesenteric artery occlusion on computed tomography (CT) angiography. Read More

Ter Arkh 2020 Apr 27;92(2):74-80. Epub 2020 Apr 27.

Chelyabinsk Regional Clinical Hospital.

Aim: To evaluate the sensitivity and specificity of the clinical criteria for the diagnosis of chronic mesenteric ischemia in elderly and senile patients with mesenteric atherosclerosis.

Materials And Methods: The study included 142 patients (82 men and 60 women). The median age of patients is 66. Read More

Med Hypotheses 2020 Jun 23;144:110023. Epub 2020 Jun 23.

Department of Gastroenterology, IBD and Nutritional Support, CHU Paris Nord-Val de Seine, Beaujon Hospital, Clichy, France.

Consistent observations report increased severity of SARS-CoV-2 infection in overweight men with cardiovascular factors. As the visceral fat possesses an intense immune activity, is involved in metabolic syndrome and is at the crossroad between the intestines, the systemic circulation and the lung, we hypothesized that it plays a major role in severe forms of SARS-CoV-2 infection. SARS-CoV2 presents the ability to infect epithelial cells of the respiratory tract as well as the intestinal tract. Read More

Mediators Inflamm 2020 10;2020:4359305. Epub 2020 Jun 10.

Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Intestinal ischemia/reperfusion (I/R) injury often causes inflammatory responses and coagulation disorders, which is further promoting the deterioration of the disease. Hydrogen has anti-inflammatory, antioxidative, and antiapoptotic properties against various diseases. However, the effect of hydrogen on coagulation dysfunction after intestinal I/R and the underlying mechanism remains unclear. Read More

Eur J Pharmacol 2020 Jun 20:173265. Epub 2020 Jun 20.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran; Brain and Spinal Injury Repair Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Acute mesenteric ischemia (AMI) is caused by an abrupt cessation of blood flow to the small intestine. Reperfusion is the return of blood flow to the ischemic bowel. Intestinal ischemia/reperfusion (I/R) leads to the formation of reactive oxygen species, local inflammatory response, and may lead to the patient's death. Read More

Eur Rev Med Pharmacol Sci 2020 Jun;24(11):6463-6469

Department of Anesthesiology, Jinan City People's Hospital, Jinan, China.

Objective: The aim of this study was to investigate the effects of propofol on intestinal ischemia-reperfusion injury in rats through the nuclear factor-kappa B (NF-κB) pathway.

Materials And Methods: A total of 24 Sprague-Dawley rats were selected and randomly divided into three groups, including sham operation group, ischemia group and propofol group. Rats in sham operation group were only treated with isolation of superior mesenteric artery, which was clipped for 1 h and reperfused for 2 h in ischemia group. Read More

Biochem Pharmacol 2020 Jun 17:114102. Epub 2020 Jun 17.

Department of Radiotherapy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China. Electronic address:

Radiation enteritis (RE) is a common side effect after radiotherapy for abdominal cancer. RE pathogenesis is complicated, with no drugs available for prevention or treatments. Intestinal ischemia is a key factor in the occurrence and development of enteritis. Read More

Ann Vasc Surg 2020 Jun 16. Epub 2020 Jun 16.

Department of Vascular and Thoracic Surgery, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Université de Paris, France; SURVI (Structure d'URgences Vasculaires Intestinales), Intestinal Stroke Center, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Université de Paris, France; Department of Vascular Surgery, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Université de Paris, France.

Purpose: To describe the use of the Outback catheter to overcome aortic re-entry issues in acute mesenteric ischemia (AMI) treated by retrograde open mesenteric stenting (ROMS).

Technique: The technique is demonstrated in two female patients presenting with late AMI related to flush occlusion of the SMA. In such cases of thrombotic AMI with clear preoperative evidence of intestinal necrosis, ROMS is the first-line revascularization technique in our intestinal stroke center. Read More

Rev Col Bras Cir 2020 3;47:e20202480. Epub 2020 Jun 3.

Universidade Federal do Rio de Janeiro, Departamento de Medicina Interna - Divisão de Hepatologia - Rio de Janeiro - RJ - Brasil.

Objective: Portomesenteric vein thrombosis (PMVT) is a potentially severe complication that can occur after bariatric surgery. PMVT has gained importance because of the increasing number of bariatric surgeries being performed. to report a rare and severe complication after bariatric surgery, which is difficult to manage. Read More

Ann Vasc Surg 2020 Jun 15. Epub 2020 Jun 15.

Department of Vascular and Endovascular Surgery, Foch Hospital, Suresnes, France.

Objectives: To report results achieved in treatment of symptomatic aortic mural thrombus in a single Institution.

Materials And Methods: A retrospective analysis of data about 97 patients presenting with acute onset lower limb ischemia (Rutherford stage II-III), upper limb ischemia and mesenteric ischemia surgically treated between January 2011 and December 2018 in the Vascular and Endovascular Unit of Foch Hospital (Suresnes, France) was conducted. Only patients affected with primary aortic mural thrombus (PAMT) as source of embolism were included. Read More

SAGE Open Med 2020 24;8:2050312120923227. Epub 2020 May 24.

Department of Gastroenterological Surgery, Kameda Medical Center, Kamogawa, Japan.

Objective: Acute mesenteric ischemia is often fatal, and many survivors develop short bowel syndrome. To avoid massive bowel resection, revascularization is recommended for acute mesenteric ischemia patients. However, whether acute mesenteric ischemia patients with clinical peritonitis can be revascularized remains uncertain. Read More

World J Hepatol 2020 May;12(5):184-206

Departments of Pharmacology and Pathology, School of Medicine, University of Zagreb, Zagreb 10000, Croatia.

Background: The Pringle maneuver [portal triad obstruction(PTO)] provides huge disturbances during ischemia and even more thereafter in reperfusion. Contrarily, a possible solution may be stable gastric pentadecapeptide BPC 157, with already documented beneficial effects in ischemia/reperfusion conditions. Recently, BPC 157, as a cytoprotective agent, successfully resolved vessel occlusions in rats (ischemic colitis; deep vein thrombosis, superior anterior pancreaticoduodenal vein; bile duct cirrhosis) through rapid collateral vessel recruitment to circumvent vessel occlusion. Read More

Arch Iran Med 2020 Jun 1;23(6):422-425. Epub 2020 Jun 1.

Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

We have recently established an intestinal rehabilitation unit (IRU) in Abu Ali Sina transplantation center affiliated to Shiraz University of Medical Sciences, Iran. Our intestinal failure rehabilitation and transplant program aims to provide state-of-the-art care for adult patients with different degrees of intestinal insufficiency and failure. In the IRU, we aimed to design an algorithmic approach to patients with small bowel ischemia and short bowel syndrome (SBS) based on our institutional experience in our country and based on other pioneering studies from other regions of the world. Read More

Int J Surg Case Rep 2020 Jun 6;72:122-126. Epub 2020 Jun 6.

Emergency Surgery Unit, Careggi University Hospital, Largo Brambilla 3, 50134, Florence, Italy. Electronic address:

Introduction: Acute mesenteric ischemia (AMI) refers to the sudden onset of intestinal hypoperfusion that can also result from splanchnic venous occlusion. The portomesenteric venous system (PMVS) is an unusual site of thrombosis in patients with protein S deficiency and its obstruction is a rare cause of AMI. Aim of this report is to illustrate a successful strategy in a case of massive small bowel infarction managed with an open abdomen (OA) approach. Read More

Surg Case Rep 2020 Jun 12;6(1):132. Epub 2020 Jun 12.

Department of Gastroenterological Surgery, Osaka City General Hospital, 2-13-22 Miyakojimahondori, Miyakojima-ku, Osaka, 534-0021, Japan.

Background: Nonocclusive mesenteric ischemia (NOMI) has been reported to be a life-threating disease. Gastric conduit necrosis is known as a critical postoperative complication after esophagectomy for esophageal cancer. We encountered a rare case of NOMI of a wide area of the intestine accompanied by gastric conduit necrosis after esophagectomy, which was successfully treated with an emergency operation. Read More

J Clin Med 2020 Jun 8;9(6). Epub 2020 Jun 8.

1st Department of Propaedeutic Internal Medicine, Endocrine Unit, National and Kapodistrian, University of Athens, 11527 Athens, Greece.

Mesenteric fibrosis (MF) constitutes an underrecognized sequela in patients with small intestinal neuroendocrine neoplasms (SI-NENs), often complicating the disease clinical course. The aim of the present systematic review, carried out by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, is to provide an update in evolving aspects of MF pathogenesis and its clinical management in SI-NENs. Complex and dynamic interactions are present in the microenvironment of tumor deposits in the mesentery. Read More

FASEB J 2020 Jun 10. Epub 2020 Jun 10.

Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.

Intestinal ischemia-reperfusion (IIR) often occurs during and following major cardiovascular or gut surgery and causes significant organ including kidney injuries. This study was to investigate the protective effect of intestinal ischemic postconditioning (IPo) on IIR-induced acute kidney injury (AKI) and the underling cellular signaling mechanisms with focus on the Nrf2/HO-1. Adult C57BL/6J mice were subjected to IIR with or without IPo. Read More

Exp Clin Transplant 2020 Jun;18(3):353-358

From the Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.

Objectives: The main objective of this experimental study was to evaluate the feasibility of diabetes induction by total pancreatectomy and pancreatic allotransplant after diabetes induction by total pancreatectomy. The secondary objective was to evaluate metabolic (C-peptide, glycemia) and inflammatory (lactate and platelet levels) parameters after diabetes induction by total pancreatectomy and pancreatic allotransplant after total pancreatectomy.

Materials And Methods: The study protocol was approved by the French Minister of Research (APAFiS no. Read More

JGH Open 2020 Jun 27;4(3):345-350. Epub 2019 Dec 27.

Department of Pathology St Vincent's Hospital Fitzroy Victoria Australia.

In 1991, Genta and Haggitt described four patients with segmental ischemic colitis caused by idiopathic myointimal hyperplasia in the small mesenteric veins (IMHMV). There are now 33 published cases of IMHMV in the literature; however, this condition is still sufficiently rare that it poses a diagnostic challenge to pathologists and clinicians and is often clinically or histologically confused with inflammatory bowel disease (IBD) or ischemic colitis. IMHMV is characterized by intimal smooth muscle hyperplasia resulting in thickened small and medium-sized mesenteric veins (with arterial sparing). Read More

J Surg Res 2020 Jun 3;254:306-313. Epub 2020 Jun 3.

Division of Thoracic & Cardiovascular Surgery, Department of Surgery, University of Virginia, Charlottesville, Virginia. Electronic address:

Background: Gastrointestinal complications after cardiac surgery are associated with high morbidity and mortality. We sought to determine the granular impact of individual gastrointestinal complications after cardiac surgery and assess contemporary outcomes.

Materials And Methods: Patients undergoing cardiac surgery from 2010 to 2017 (6070 patients) were identified from an institutional Society of Thoracic Surgeons database. Read More

Acad Radiol 2020 May 23. Epub 2020 May 23.

Department of Anesthesiology and Critical Care Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu & Kashmir, India.

Radiol Clin North Am 2020 Jul 12;58(4):797-813. Epub 2020 May 12.

Department of Radiology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55901, USA. Electronic address:

MR angiography is a flexible imaging technique enabling morphologic assessment of mesenteric arterial and venous vasculature. Conventional gadolinium-based contrast media and ferumoxytol are used as contrast agents. Ferumoxytol, an intravenous iron replacement therapy approved by the US Food and Drug Administration for iron deficiency anemia, is an effective and well tolerated blood pool contrast agent. Read More

Intern Med 2020 May 26. Epub 2020 May 26.

Department of Cardiovascular Medicine, Okayama City Hospital, Japan.

Superior mesenteric venous thrombosis (SMVT), which results from various etiologies, including coagulation disorders, can be diagnosed early using advanced imaging technology. However, few reports have described the nonsurgical treatment of acute peritonitis caused by SMVT. We encountered a young woman whose history included abdominal pain and daily oral contraceptives and who presented with acute peritonitis caused by SMVT. Read More

Int J Surg Case Rep 2020 21;71:128-131. Epub 2020 May 21.

Department of Radiology, Trauma and BurnCenter of Ben Arous, Tunisia.

Introduction: The celiacomesenteric trunk (CMT) is one of the most striking among the different variations of the normal vascularisation of the gastro-intestinal tract. It is often accidentally discovered during autoptical dissections, angiography or abdominal computed tomography (CT).

Case Presentation: A 27-year-old man was admitted to emergency for an acute abdominal pain. Read More

Int J Surg Case Rep 2020 11;70:249-250. Epub 2020 May 11.

Doncaster Royal Infirmary, Thorne Road, Doncaster DN2 5LT, United Kingdom. Electronic address:

Introduction: Mesenteric artery re-vascularization using bypass or angioplasty is a standard of care in atherosclerotic mesenteric vascular disease. However, there are no certain guidelines for the management of non-atherosclerotic thrombophilic mesenteric vessel disease other than anti-coagulation.

Case Report: We are reporting a case of a 36 years old lady with post-prandial angina and weight loss on the background of anti-phospholipid syndrome having tripple mesentric vessel occlusive disease who underwent 2 vessel aorto-mesenteric bypass. Read More

Cardiovasc Intervent Radiol 2020 May 22. Epub 2020 May 22.

Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital, Carl Gustav Carus University, TU Dresden, Fetscherstr. 74, 01307, Dresden, Germany.

Purpose: To investigate the outcome of local intra-arterial papaverine infusion therapy in patients with non-occlusive mesenteric ischemia (NOMI), and factors influencing survival, in comparison with a conservative approach.

Methods: From 2013 to 2019, patients with NOMI confirmed by imaging were included in a retrospective two-center study. According to different in-house standard procedures, patients were treated in each center either conservatively or interventionally by a standardized local infusion of intra-arterial papaverine into the splanchnic arteries. Read More

Int J Surg Case Rep 2020 15;71:73-77. Epub 2020 May 15.

General Surgery 2U - Liver Transplant Unit, A.O.U. Città della Salute e della Scienza di Torino, University of Torino, Torino, Italy. Electronic address:

Introduction: Once considered a contraindication to liver transplantation, portal vein thrombosis still represents a significant challenge to the liver transplant surgeon. Yerdel grade 3 thrombosis is usually managed by interposing a donor iliac vein jump graft between graft portal vein and distal superior mesenteric vein. Venous patch is normally placed in a retrogastric position to avoid its kinking. Read More

Plast Reconstr Surg Glob Open 2020 Apr 29;8(4):e2794. Epub 2020 Apr 29.

Department of Plastic and Reconstructive Surgery, Yachiyo Medical Center, Tokyo Women's Medical University, Yachiyo-shi, Chiba, Japan.

Incisional hernia often complicates kidney transplant. However, there are few reports showing pitfalls after the repair of incisional hernia following living-donor kidney transplant. A 55-year-old man underwent living-donor kidney transplant from his wife at the Department of Urology at the authors' hospital. Read More

Surgery 2020 May 18. Epub 2020 May 18.

Center for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY; Department of Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY; Elmezzi Graduate School of Molecular Medicine, Manhasset, NY. Electronic address:

Background: Intestinal ischemia-reperfusion injury results in morbidity and mortality from both local injury and systemic inflammation and acute lung injury. Extracellular cold-inducible RNA-binding protein is a damage associated molecular pattern that fuels systemic inflammation and potentiates acute lung injury. We recently discovered a triggering receptor expressed on myeloid cells-1 serves as a novel receptor for extracellular cold-inducible RNA-binding protein. Read More

Biosci Rep 2020 Jun;40(6)

Department of Cardiovascular, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650101, China.

The present study was designed to investigate the role of amylin, H2S, and connexin 43 in vascular dysfunction and enhanced ischemia-reperfusion (I/R)-induced myocardial injury in diabetic rats. A single dose of streptozotocin (65 mg/kg) was employed to induce diabetes mellitus. After 8 weeks, there was a significant decrease in the plasma levels of amylin, an increase in I/R injury to isolated hearts (increase in CK-MB and cardiac troponin release) on the Langendorff apparatus. Read More

Front Pharmacol 2020 6;11:563. Epub 2020 May 6.

Trauma Research Center, Fourth Medical Center of the Chinese PLA General Hospital, Beijing, China.

Background: Vasopressin is an efficient remedy for septic shock patients as its great capacity in promoting hemodynamic stabilization. The aim of current systematic review and meta-analysis is to compare the clinical efficiency of vasopressin or its analogs with sole catecholamines on patients with septic shock.

Methods: A systematic search of Cochrane Library, EMBASE, and PubMed online databases was performed up to 30 Oct 2019 to identify randomized controlled trials comparing use of vasopressin or its analogs (e. Read More

Ann Vasc Surg 2020 May 16. Epub 2020 May 16.

Section of Vascular Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH.

Background: Endovascular therapy for chronic mesenteric ischemia (CMI) is the mainstay of treatment. Duplex velocity criteria within stented mesenteric vessels are not well established. We describe single-center outcomes of mesenteric stenting for CMI and analyze duplex velocities associated with in-stent restenosis (ISR). Read More

Intensive Care Med 2020 May 18. Epub 2020 May 18.

Hopital Saint-Antoine, Paris, France.

J Am Coll Surg 2020 Jul 15;231(1):8-29. Epub 2020 May 15.

Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic College of Medicine, Rochester, MN.

Background: En bloc celiac axis resection (CAR) for pancreatic cancer is considered increasingly after modern neoadjuvant chemotherapy (NAC). Appleby and distal pancreatectomy with CAR are anatomically inaccurate terms, as tumors can extend beyond celiac axis proper, requiring concurrent resection of the proper hepatic artery and/or superior mesenteric artery.

Study Design: A 3-level classification for CAR (class 1, 2, or 3) was developed after retrospective review of an arterial resection database describing anatomical variants that dictate pancreatectomy-type, formal arterial revascularization, and gastric preservation. Read More

Acta Medica (Hradec Kralove) 2020 ;63(1):43-48

Clinic of Vascular Surgery, East Slovak Institute of Cardiovascular Diseases, Faculty of Medicine, Pavol Jozef Šafárik University, Košice, Slovak Republic.

The paper presents the results of treating 14 patients, namely eight patients with visceral artery aneurysms and six patients with visceral artery pseudoaneurysms. In 64.3% of the patients, the initial diagnosis was made based on the ultrasound examination. Read More

Frontline Gastroenterol 2020 3;11(3):253-254. Epub 2019 May 3.

Palermo, Italy.

Vasc Endovascular Surg 2020 May 18:1538574420927132. Epub 2020 May 18.

Department of Diagnostic and Interventional Radiology, RWTH University Hospital Aachen, Aachen, Germany.

Purpose: The antegrade recanalization of an occlusion or high-grade stenosis of the celiac artery via the aorta often represents a technical challenge. A retrograde approach via the superior mesenteric artery and the pancreaticoduodenal arcade may be an alternative approach. Based on our experience, we assess the technical success and the short- and mid-term outcomes of this bailout procedure. Read More

J Surg Res 2020 May 8;254:7-15. Epub 2020 May 8.

Department of Visceral-, Transplantation-, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany.

Background: Acute mesenteric ischemia is a life-threatening acute condition, which requires an interdisciplinary approach, including vascular recanalization and surgical treatment. Visual evaluation of intestinal perfusion might be misleading, and therefore, additional tools are necessary to reliably be able to resect the ischemic intestine. Hyperspectral imaging (HSI) has been shown to be feasible and safe for real-time assessment of tissue perfusion in visceral surgery but has never been used in cases of acute mesenteric ischemia. Read More

Eur J Case Rep Intern Med 2020 30;7(5):001690. Epub 2020 Apr 30.

Emergency Department, ASST di Cremona, Cremona, Italy.

A 52-year-old patient with SARS-CoV-2 was diagnosed with interstitial pneumonia and treated with darunavir/ritonavir, hydroxychloroquine, azithromycin and low molecular weight heparin (LMWH). After LMWH cessation, he developed superior mesenteric arterial thrombosis. An abdominal CT scan showed arterial thrombosis of vessels efferent of the superior mesenteric artery with bowel distension. Read More

Am Surg 2020 Apr;86(4):e177-e179

Clin Hemorheol Microcirc 2020 May 4. Epub 2020 May 4.

Department of Surgery, University of California San Francisco East Bay, Oakland, CA, USA.

Background: Autotaxin (ATX-secretory lysophospholipase D) is the primary lysophosphatidic acid (LPA) producing enzyme. LPA promotes endothelial hyper-permeability and microvascular dysfunction following cellular stress.

Objective: We sought to assess whether ATX inhibition would attenuate endothelial monolayer permeability after anoxia-reoxygenation (A-R) in vitro and attenuate the increase in hydraulic permeability observed after ischemia-reperfusion injury (IRI) in vivo. Read More

Gan To Kagaku Ryoho 2020 Apr;47(4):643-645

Dept. of Surgery, Japan Community Health Care Organization Shimonoseki Medical Center.

Abdominal computed tomography(CT)revealed ileus due to sigmoid colon cancer in a 68-year-old man with abdominal pain, and endoscopic decompression using a transanal ileus tube was attempted. The blood test on the following day showed a marked increase in CRP 46.13mg/dL. Read More

Radiologia 2020 May 5. Epub 2020 May 5.

Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.

Acute mesenteric ischemia is an abdominal emergency because reduced blood flow to bowel loops rapidly leads to irreversible necrosis and death. This paper reviews the different conditions (arterial, venous, low-flow states) that can result in reduced blood flow to bowel loops. Since the clinical and laboratory findings are nonspecific, imaging tests play an important role in the diagnosis of mesenteric ischemia. Read More

Georgian Med News 2020 Mar(300):59-63

Medical University of Karaganda, Republic of Kazakhstan.

This article highlights the current problems of studying and diagnosing the phenomenon of bacterial translocation in acute mesenteric ischemia. The urgency of problem is due to high mortality, reaching 60-70% against the background of development of systemic complications. A key element in the development of complications is the phenomenon of microbial translocation. Read More

Abdom Radiol (NY) 2020 May 7. Epub 2020 May 7.

Division of Cardiovascular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.

Purpose: The purpose of this study was to identify the significant imaging predictors of transmural intestinal necrosis in patients with acute mesenteric ischemia (AMI).

Methods: The medical records and CT imaging of 48 patients between 2011 and 2019 suspected of having AMI that underwent exploratory laparotomy with bowel resection and pathological confirmation of ischemic bowel injury were retrospectively reviewed. Using histopathology as a gold standard, various parameters related to vascular insufficiency and bowel injury were analyzed and correlated with outcome of ischemic bowel necrosis using nonparametric tests. Read More

Surg Infect (Larchmt) 2020 May 5. Epub 2020 May 5.

Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Acute intestinal ischemia-reperfusion injury (AIIRI) is a devastating clinical condition relevant to multiple diseases processes, including sepsis, trauma, transplantation, and burns. An AIIRI is a contributor to the development of multiple organ dysfunction syndrome (MODS). Oncostatin M (OSM)/oncostatin M receptor (OSMR) signaling is an unrecognized and novel candidate pathway for the mediation of MODS. Read More

AJR Am J Roentgenol 2020 Jul 6;215(1):29-38. Epub 2020 May 6.

Department of Radiology, University Hospitals Paris Nord Val de Seine, Beaujon Hospital, AP-HP, 100 Blvd du Général Leclerc. 92118 Clichy, France.

The purpose of this article is to provide an overview of the diagnostic and prognostic roles of CT in the management of acute mesenteric ischemia. Acute mesenteric ischemia is defined as inadequate blood supply to the gastrointestinal tract resulting in ischemic and inflammatory injury. The prognosis is poor without treatment. Read More