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Biomed Pharmacother 2022 Jun 22;153:113320. Epub 2022 Jun 22.

Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Acute mesenteric ischemia is known as a life threatening condition. Re-establishment of blood flow in this condition can lead to mesenteric ischemia reperfusion (MIR) injury which is accompanied by inflammatory response. Still, clear blueprint of inflammatory mechanism underlying MIR injury has not been provided. Read More

Biomedicines 2022 Jun 1;10(6). Epub 2022 Jun 1.

Department of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.

We revealed the therapy effect of the stable gastric pentadecapeptide BPC 157 (10 μg/kg, 10 ng/kg ig or po) with specific activation of the collateral rescuing pathways, the azygos vein, on bile duct ligation in particular, and acute pancreatitis as local disturbances (i.e., improved gross and microscopy presentation, decreased amylase level). Read More

BMC Gastroenterol 2022 Jun 22;22(1):304. Epub 2022 Jun 22.

Fujian Medical University, No.1 Xuefu bei Road, Fuzhou, 350122, Fujian Province, China.

Background: Distinguishing strangulated bowel obstruction (StBO) from simple bowel obstruction (SiBO) still poses a challenge for emergency surgeons. We aimed to construct a predictive model that could distinctly discriminate StBO from SiBO based on the degree of bowel ischemia.

Methods: The patients diagnosed with intestinal obstruction were enrolled and divided into SiBO group and StBO group. Read More

Asian J Surg 2022 Jun 17. Epub 2022 Jun 17.

Department of Surgery, Kawasaki Saiwai Hospital, Kawasaki, Japan.

Radiol Case Rep 2022 Aug 11;17(8):2869-2873. Epub 2022 Jun 11.

MD at Radiology Unit of Riuniti Hospital, Azienda Ospedaliera Grande Ospedale Metropolitano (G.O.M.) "Bianchi-Melacrino-Morelli", Reggio, Calabria, Italy.

Superior mesenteric artery (SMA) and superior mesenteric vein (SMV) thrombotic occlusion is a rare but potentially fatal condition. Though isolated mesenteric arterial occlusion associated with COVID-19 has been reported in literature, combined superior mesenteric arterial and venous thrombosis is very rare. We report the case of an 88-years-old woman with a combined superior mesenteric arterial and venous thrombotic occlusion with a previous COVID-19 pneumonia of about 15 days before, diagnosed at computed tomography angiography (CTA) scan. Read More

Inflammation 2022 Jun 14. Epub 2022 Jun 14.

Department of Anesthesiology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Ave N, Guangzhou, 510515, China.

Liver injury induced by intestinal ischemia/reperfusion (I/R) is accompanied by the polarization of Kupffer cells, which are specialized macrophages located in the liver. However, the causes of hepatic macrophage polarization after intestinal I/R remain unknown. This study investigated whether gut-derived exosomes contribute to the pathogenesis of liver injury triggered by intestinal I/R in a murine model and explored the underlying mechanisms. Read More

Cir Esp 2022 Jun 5. Epub 2022 Jun 5.

Servicio de Cirugía Gastrointestinal, Hospital Clínic i Provincial de Barcelona, Barcelona, España.

J Cardiovasc Surg (Torino) 2022 Jun 10. Epub 2022 Jun 10.

Division of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, AB, Canada -

Introduction: The objective of this study is to provide a comprehensive comparison of outcomes following acute type A aortic dissection (ATAAD) repair in males and females.

Evidence Acquisition: PubMed, Medline, and Web of Science were systematically searched by 2 authors for studies published from January 1st, 2000, to May 10th, 2021. 2,405 articles were screened, and 16 were included in this review. Read More

Cureus 2022 May 8;14(5):e24819. Epub 2022 May 8.

Internal Medicine, Jersey City Medical Center, Jersey City, USA.

Although isolated superior mesenteric artery dissection is a rare disease entity, it possesses high mortality. The pathophysiology remains a mystery. In this case, we report a 68-year-old male with compromised coronary circulation been evaluated for coronary artery bypass surgery (CABG) and who developed a sudden, localized, right-sided abdominal pain. Read More

Front Med (Lausanne) 2022 23;9:826446. Epub 2022 May 23.

Service de Médecine Intensive Réanimation, Centre Médico-Chirurgical Ambroise Paré, Neuilly-sur-Seine, France.

Vasodilatory shock, such as septic shock, requires personalized management which include adequate fluid therapy and vasopressor treatments. While these potent drugs are numerous, they all aim to counterbalance the vasodilatory effects of a systemic inflammatory response syndrome. Their specific receptors include α- and β-adrenergic receptors, arginine-vasopressin receptors, angiotensin II receptors and dopamine receptors. Read More

J Clin Exp Hepatol 2022 May-Jun;12(3):965-979. Epub 2021 Nov 22.

Department of Gastroenterology, Seth GS Medical College and KEM Hospital, Mumbai, India.

Patients with cirrhosis of the liver are at high risk of developing portal vein thrombosis (PVT), which has a complex, multifactorial cause. The condition may present with a myriad of symptoms and can occasionally cause severe complications. Contrast-enhanced computed tomography (CT) is the gold standard for the diagnosis of PVT. Read More

Cureus 2022 May 5;14(5):e24761. Epub 2022 May 5.

Emergency and Critical Care Center, Kurashiki Central Hospital, Kurashiki, JPN.

A 67-year-old man developed an abdominal aortic aneurysm (AAA) and Stanford type B acute aortic dissection. He received liberal antihypertensives for complicated spinal cord ischemia and, subsequently, experienced loss of appetite, followed by vomiting without abdominal pain. Computed tomography revealed AAA expansion and compression of the duodenum between the superior mesenteric artery (SMA) and AAA. Read More

Clin Med Res 2022 Jun 8. Epub 2022 Jun 8.

Division of Gastroenterology and Nutrition, Loyola University Medical Center, Maywood, IL.

Background: Nonocclusive mesenteric ischemia (NOMI) is due to mesenteric arterial hypoperfusion from several causes, such as hypovolemia, heart failure, shock, vasoconstrictors, and severe liver or renal disease. Vasoconstrictor-induced NOMI is usually iatrogenic or associated with cocaine use.

Objectives: Anecdotal reports suggest that cocaine-induced NOMI has the highest mortality among vasoconstrictors. Read More

Cir Esp (Engl Ed) 2022 Jun 5. Epub 2022 Jun 5.

Servicio de Cirugía Gastrointestinal, Hospital Clínic i Provincial de Barcelona, Barcelona, Spain.

Front Med (Lausanne) 2022 18;9:879996. Epub 2022 May 18.

Department of Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Gastrointestinal symptoms are common among COVID-19 patients. Although gastrointestinal involvements are mostly benign, they rarely indicate a severe pathology like intestinal ischemia. The present case series describes 21 patients with bowel ischemia, necrosis, or perforation. Read More

World J Clin Cases 2022 May;10(13):4161-4170

Department of Hematology, Peking Union Medical College Hospital, Beijing 100730, China.

Background: A 46-year-old Han man first had sigmoid sinus and transverse sinus venous thrombosis at the age of 42. At the age of 44, he once again developed thrombosis. Genetic testing showed heterozygous SERPINC1 mutation, bone marrow biopsy showed fibrosis grade 1 (MF-1), and JAK2 V617F mutation was positive, accompanied by UGT1A1 mutation and β-thalassemia gene mutation. Read More

World J Emerg Surg 2022 06 3;17(1):32. Epub 2022 Jun 3.

Division of Gastroenterological Surgery, Department of Surgery, Aichi Medical University, 1-1, Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.

Background: The criteria for deciding upon non-operative management for nonocclusive mesenteric ischemia (NOMI) are poorly defined. The aim of this study is to determine the prognostic factors for survival in conservative treatment of NOMI.

Methods: Patients with bowel ischemia were identified by searching for "ICD-10 code K550" in the Diagnosis Procedure Combination database between June 2015 and May 2020. Read More

BMC Surg 2022 Jun 3;22(1):214. Epub 2022 Jun 3.

Second Affiliated Hospital of Soochow University, Suzhou, China.

Background: Nonocclusive mesenteric ischemia (NOMI) is defined as acute intestinal ischemia because of decreased blood flow in mesenteric vessels. Only a few cases of NOMI that occur secondary to aortic dissection (AD) have been reported, resulting in the lack of sufficient knowledge of diagnosis and treatment.

Case Presentation: We aimed to report a case of NOMI caused by type B Aortic Dissection. Read More

Ann Vasc Surg 2022 May 30. Epub 2022 May 30.

Division of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center, New York, NY. Electronic address:

Background: Potential complications of pelvic flow disruption during aortic aneurysm repair include buttock ischemia and mesenteric ischemia. Unilateral or bilateral hypogastric artery flow interruption, either from atherosclerosis or intentionally to facilitate aneurysm repair, is considered problematic in endovascular repair; however, it has not been well studied in open abdominal aortic aneurysm (AAA) repair (OAR). We sought to examine the effect of interruption of flow to one or both hypogastric arteries on outcomes after OAR. Read More

Pharmacol Res Perspect 2022 Jun;10(3):e00975

Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.

A and A adenosine receptors produce regionally selective regulation of vascular tone and elicit differing effects on mean arterial pressure (MAP), whilst inducing tachycardia. The tachycardia induced by the stimulation of A or A receptors has been suggested to be mediated by a reflex increase in sympathetic activity. Here, we have investigated the role of β - and β -adrenoceptors in mediating the different cardiovascular responses to selective A and A receptor stimulation. Read More

Ann Med Surg (Lond) 2022 May 3;77:103719. Epub 2022 May 3.

Nepalese Army Institute of Health Sciences, Sanobharyang, Kathmandu, Nepal.

Introduction: Mesenteric venous thrombosis is due to blood clot in veins that drain blood from the intestine. It may lead to mesenteric ischemia. Protein S deficiency is one of the causes of superior mesenteric vein thrombosis. Read More

Radiol Case Rep 2022 Jul 20;17(7):2568-2572. Epub 2022 May 20.

Department of Radiological Sciences, Oncology and Pathology, "Sapienza" University of Rome - I.C.O.T. Hospital, Via Franco Faggiana, 1668, 04100, Latina, Italy.

Acute Mesenteric Ischemia (AMI) is a rare life-threatening entity caused by sudden interruption of the blood supply to a segment of the bowel due to impairment of mesenteric arterial blood flow or venous drainage. Clinical presentation varies according to the time course of vascular occlusion. Contrast-enhanced Computed Tomography (CT) of the abdomen represents the main diagnostic test for AMI diagnosis, enabling fast and excellent evaluation of the intestine, mesenteric vasculature, and other ancillary characteristics of AMI. Read More

Int J Mol Sci 2022 May 16;23(10). Epub 2022 May 16.

MITOVASC, Equipe CarMe, CNRS 6015, Inserm 1083, Angers Université, 49100 Angers, France.

Hypoxia and inflammation play a major role in revascularization following ischemia. Sildenafil inhibits phosphodiesterase-5, increases intracellular cGMP and induces revascularization through a pathway which remains incompletely understood. Thus, we investigated the effect of sildenafil on post-ischemic revascularization. Read More

J Vasc Surg Cases Innov Tech 2022 Jun 12;8(2):293. Epub 2022 Apr 12.

Division of Vascular and Endovascular Surgery, University of Arkansas for Medical Sciences, Little Rock, AR.

Kyobu Geka 2022 Jun;75(6):411-415

Department of Cardiovascular Surgery, Japanese Red Cross Nagaoka Hospital, Nagaoka, Japan.

A 52-year-old man developed Stanford type A acute aortic dissection and suffered severe pain in the back and the chest, and numbness of the left lower limb. Contrast-enhanced computed tomography (CT) revealed occlusion of the left iliac artery due to dissection. The celiac artery was also obstructed and the superior mesenteric artery was severely narrowed, but there was no clear sign of organ ischemia. Read More

J Pak Med Assoc 2022 Apr;72(4):755-757

Department of Surgery, Mayo Hospital, Lahore, Pakistan.

A 57 years old male presented in the emergency department of EAST Surgical Ward, MAYO Hospital Lahore in February 2021 with complaints of abdominal distension, pain and vomiting. He was a chronic smoker and diagnosed hypertensive for the last 14 years but was non-compliant with oral antihypertensive medications. He was a factory worker and took NSAIDs off and on for pain in the knee joint for the last five years. Read More

J Gen Intern Med 2022 May 24. Epub 2022 May 24.

Department of Medicine, University of California San Francisco, San Francisco, CA, USA.

Cureus 2022 Apr 20;14(4):e24313. Epub 2022 Apr 20.

School of Medicine, Universidade Para o Desenvolvimento do Alto Vale do Itajaí, Rio do Sul, BRA.

Hepatic portal venous gas (HPVG) is a condition where air embolization from disrupted intestinal mucosa reaches the portal system. It is an uncommon finding and denotes severity. This report describes HPVG as a rare and lethal complication of enteral nutrition. Read More

Int Immunopharmacol 2022 Jul 18;108:108852. Epub 2022 May 18.

Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, PR China. Electronic address:

Isoliquiritin apioside (IA), a critical ingredient of Glycyrrhizae radix et rhizoma, has been unveiled to possess remarkable pharmacological activity against oxidative stress and inflammation. However, the potential roles of IA in intestinal ischemia/reperfusion (I/R)-induced acute lung injury (ALI) have not been reported yet. In the present study, we explored the effects of IA on I/R-induced ALI, and also clarified the possible mechanisms. Read More

Ann Vasc Surg 2022 May 17. Epub 2022 May 17.

Advanced Endovascular Aortic Research Program, Mayo Clinic, Rochester, MN. Electronic address:

Background: To evaluate outcomes following urgent or emergent fenestrated-branched endovascular aortic repair (F-BEVAR) for pararenal (PRA) and thoracoabdominal aortic aneurysms (TAAA) in patients who are considered high-risk for open repair.

Methods: A retrospective, single institution evaluation of outcomes following F-BEVAR of symptomatic, rapidly enlarging, or ruptured PRA or TAAA treated with physician modified endograft (PMEG) and company manufactured devices (CMD). Outcomes were technical success, 30-day morbidity and mortality, and 1 year aortic related outcomes. Read More