63,225 results match your criteria Mesenteric Lymphadenitis


Impaired Kv7 channel function in cerebral arteries of a tauopathy mouse model (rTg4510).

Physiol Rep 2018 Dec;6(23):e13920

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

In tauopathies, such as Alzheimer's disease with or without concomitant amyloid β plaques, cerebral arteries display pathological remodeling, leading to reduced brain tissue oxygenation and cognitive impairment. The precise mechanisms that underlie this vascular dysfunction remain unclear. Kv7 voltage-dependent K channels contribute to the development of myogenic tone in rat cerebral arteries. Read More

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December 2018

Intravascular Ultrasound-Assisted Endovascular Treatment of Mesenteric Malperfusion in a Multichannel Aortic Dissection With Full True Lumen Collapse.

J Endovasc Ther 2018 Dec 14:1526602818815821. Epub 2018 Dec 14.

1 Department of Vascular Surgery, Zhongshan Hospital Fudan University, Shanghai, China.

Purpose: To describe endovascular treatment of mesenteric malperfusion in a multichannel aortic dissection (MCAD) with full true lumen (TL) collapse following thoracic endovascular aortic repair (TEVAR).

Case Report: A 54-year-old man presented with chronic mesenteric ischemia and a previous TEVAR for MCAD complicated by superior mesenteric artery (SMA) malperfusion. Computed tomography angiography (CTA) demonstrated a 3-channel aortic dissection with a "false-true-false" configuration. Read More

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December 2018

Coronary-carotid artery collateral formation in Takayasu's arteritis: First reported case in the literature.

J Cardiol Cases 2014 Apr 28;9(4):151-153. Epub 2014 Jan 28.

Department of Cardiology, Istanbul Medicine Hospital, İstanbul, Turkey.

We present the first case report of coronary-carotid artery collateral formation in Takayasu's arteritis. There was a vasculitic involvement of both subclavian and carotid arteries with critical stenosis; cerebral perfusion was supported with collaterals arising from the mesenteric arteries and coronary artery. < A case of coronary-carotid artery collateral formation in Takayasu's arteritis is presented. Read More

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An isolated spontaneous dissecting celiac artery aneurysm with successful endovascular treatment using stenting and coil embolization.

J Cardiol Cases 2016 May 2;13(5):155-157. Epub 2016 Mar 2.

Tokyo Metropolitan Health and Medical Treatment Corporation Ohkubo Hospital, Tokyo, Japan.

Isolated spontaneous dissecting celiac artery aneurysm (DCAA) is a rare event. We report the case of a 50-year-old Japanese man with sudden post-prandial epigastric pain. He was diagnosed as having an isolated DCAA based on the results of contrast-enhanced multi-slice computed tomography (CT). Read More

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Acute heart failure due to chronic juxtarenal aortic occlusion in a patient with antiphospholipid antibody syndrome.

J Cardiol Cases 2014 Aug 19;10(2):69-72. Epub 2014 Jun 19.

Division of Thoracic and Cardiovascular Surgery, Shizuoka Saiseikai General Hospital, Shizuoka, Japan.

Abdominal aortic occlusions are rare, but occasionally life threatening. A 48-year-old man was hospitalized due to acute heart failure accompanied by acute kidney injury (AKI). Abdominal ultrasound revealed deteriorating blood flow in the bilateral renal arteries. Read More

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Aggressive undifferentiated pleomorphic sarcoma of the stomach involving long-term survival: A case report and literature review.

Mol Clin Oncol 2018 Dec 5;9(6):661-665. Epub 2018 Oct 5.

Department of Pathology, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo 113-0021, Japan.

Primary gastric undifferentiated pleomorphic sarcoma (UPS) is a rare disease with insufficient long-term follow-up data. In the present study, a 70-year-old male complained of abdominal fullness and visited our hospital. Abdominal computed tomography revealed a large tumor in the upper part of the stomach, which was accompanied by smaller tumors in the small intestinal mesentery. Read More

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December 2018

Development of insulin resistance in Nischarin mutant female mice.

Int J Obes (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Department of Biochemistry and Molecular Biology, LSUHSC School of Medicine, New Orleans, LA, 70112, USA.

Background/objectives: NISCH-STAB1 is a newly identified locus correlated to human waist-hip ratio (WHR), which is a risk indicator of developing obesity-associated diabetes. Our previous studies have shown that Nisch mutant male mice increased glucose tolerance in chow-fed conditions. Thus we hypothesized that Nisch mutant mice will have changes in insulin resistance, adipocytes, hepatic steatosis when mice are fed with high-fat diet (HFD). Read More

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December 2018

Altered Purinergic Receptor Sensitivity in Type 2 Diabetes-Associated Endothelial Dysfunction and Up₄A-Mediated Vascular Contraction.

Int J Mol Sci 2018 Dec 7;19(12). Epub 2018 Dec 7.

Unit of Cardiology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm 17176, Sweden.

Purinergic signaling may be altered in diabetes accounting for endothelial dysfunction. Uridine adenosine tetraphosphate (Up₄A), a novel dinucleotide substance, regulates vascular function via both purinergic P1 and P2 receptors (PR). Up₄A enhances vascular contraction in isolated arteries of diabetic rats likely through P2R. Read More

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December 2018

Biology-Based Surgery: The Extent of Lymphadenectomy in Cancer of the Colon.

Eur Surg Res 2018 Dec 13;59(5-6):371-379. Epub 2018 Dec 13.

The progression of colon cancer (CC) involves hematogenous and lymphatic spread to locoregional lymph nodes (LN), distant LN, and metastatic sites including the liver. The biological mechanisms that govern CC progression remain elusive. The Halsted model assumes an orderly, stepwise progression from the primary tumor to nearby nodes, henceforth to anatomically more distant nodes, and ultimately to distant organs. Read More

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December 2018

Fully robotic Ivor-Lewis esophagectomy (RAMIE4) for esophageal cancer after emergency surgery and ligation of the gastroduodenal artery.

J Int Med Res 2018 Dec 13:300060518814682. Epub 2018 Dec 13.

Department of General, Visceral and Transplant Surgery, University Medical Center of Johannes Gutenberg University, Mainz, Germany.

We report a case of a 69-year-old patient with esophageal cancer and severe upper gastrointestinal bleeding during neoadjuvant radiochemotherapy who required mass transfusion followed by complex emergency procedures. Despite endoscopic stenting, the bleeding recurred, and thus emergency open surgery was required. Gastric wedge resection of the minor curvature necessitated by perforation caused by the endoscopic stent maneuver and duodenotomy with ligation of the gastroduodenal artery, as the cause of persistent intraluminal bleeding, were performed. Read More

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December 2018

Standardize the Surgical Technique and Clarify the Relevant Anatomic Concept for Complete Mobilization of Colonic Splenic Flexure Using da Vinci Xi Robotic System.

World J Surg 2018 Dec 12. Epub 2018 Dec 12.

Division of Colorectal Surgery, Department of Surgery, National Taiwan University Hospital and College of Medicine, No. 7, Chung-Shan South Road, Taipei, Taiwan, ROC.

Background: The present study is to set up a standardized approach for complete mobilization of colonic splenic flexure using da Vinci Xi robotic system, based on clarification of the mesenteric structures of distal transverse colon.

Methods: The surgical outcomes and relevant anatomic structures of 104 consecutive patients undergoing robotic resection of primary colorectal cancer with the intent of complete mobilization of colonic splenic flexure using da Vinci Xi robotic system were retrospectively reviewed.

Results: Complete mobilization of colonic splenic flexure can be efficiently performed by the Xi robotic system, as demonstrated by short operation time, minimal intra-operative blood loss, and few surgical complications. Read More

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December 2018

The investigation of incidence and multidetector computed tomography findings of median arcuate ligament syndrome

Turk J Med Sci 2018 12 12;48(6):1214-1218. Epub 2018 Dec 12.

Department of Radiology, Faculty of Medicine, Fırat University, Elazığ, Turkey

Background/aim: This study aims to evaluate the incidence and multidetector computed tomography (MDCT) findings of median arcuate ligament syndrome (MALS).

Materials And Methods: Between January 2010 and September 2016 a total of 4028 patients who underwent angiography for MDCT based on the clinical indications for abdominal pain were retrospectively analyzed.

Results: The typical signs of MALS were identified in a total of 141 (3. Read More

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December 2018

Effect of age, sex, and season on the prevalence of Linguatula serrata infestation in mesenteric lymph nodes of goats slaughtered in Tabriz, Iran.

Trop Anim Health Prod 2018 Dec 6. Epub 2018 Dec 6.

Young Researchers and Elite Club, Zabol Branch, Islamic Azad University, Zabol, Iran.

This research was conducted to determine the prevalence and intensity of infection with nymphs of Linguatula serrata in mesenteric lymph nodes of the goats from northwest of Iran. Moreover, the intensity of infection of mesenteric lymph nodes was compared based on gross appearance and the morphological changes in these nodes. In addition, the effects of age, sex, and season on the prevalence of Linguatula serrata were assessed. Read More

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December 2018

Creation of Straight-Chain Cationic Polysaccharide-Based Bile Salt Sequestrants Made from Euglenoid β-1,3-Glucan as Potential Antidiabetic Agents.

Pharm Res 2018 Dec 6;36(1):23. Epub 2018 Dec 6.

Technical Research Center, KOBELCO Eco-Solutions Co., Ltd., 1-1-4 Murotani, Kobe, Hyogo, 651-2241, Japan.

Purpose: Straight-chain polysaccharides have a greater potential of selectively adsorbing hydrophobic bile salts than resin-based bile salt sequesters because of ionic and hydrophobic interactions; hence, they may possess antidiabetic activity. The feasibility of using cationic polysaccharides made from euglenoid β-1,3-glucan (referred to as paramylon) as potential antidiabetic agents was examined by using in vitro and animal experiments.

Methods: Cationic straight-chain polysaccharides were synthesized from euglenoid polysaccharide and glycidyltrimethylammonium chloride. Read More

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December 2018

Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life.

Mucosal Immunol 2018 Dec 6. Epub 2018 Dec 6.

Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, 10032, USA.

Defining adaptive immunity with the complex structures of the human gastrointestinal (GI) tract over life is essential for understanding immune responses to ingested antigens, commensal and pathogenic microorganisms, and dysfunctions in disease. We present here an analysis of lymphocyte localization and T cell subset composition across the human GI tract including mucosal sites (jejunum, ileum, colon), gut-associated lymphoid tissues (isolated lymphoid follicles (ILFs), Peyer's patches (PPs), appendix), and mesenteric lymph nodes (MLNs) from a total of 68 donors spanning eight decades of life. In pediatric donors, ILFs and PP containing naïve T cells and regulatory T cells (Tregs) are prevalent in the jejunum and ileum, respectively; these decline in frequency with age, contrasting stable frequencies of ILFs and T cell subsets in the colon. Read More

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December 2018

The Toldt fascia: A historic review and surgical implications in complete mesocolic excision for colon cancer.

Asian J Surg 2018 Dec 3. Epub 2018 Dec 3.

Division of Colorectal Surgery, Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

To clarify the anatomic concept of Toldt fascia, based on the literature review and the surgical anatomic dissection using laparoscopic or robotic approach. We undertook review of the historic literature and surgical videos from 250 patients with colorectal cancer operated on laparoscopically or robotically to discuss the surgical implications of Toldt fascia in complete mesocolic excision for colon cancer. Toldt fascia, sandwiched by the overlying mesothelial layer of the mesocolon and underlying mesothelial layer of the retroperitoneum, comprised loose fibrous tissues with minute vessels inside, and was contiguous from the ileocecal mesentery radix to the upper rectum. Read More

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December 2018

Laparoscopy for blunt abdominal trauma: A Challenging Endeavor.

Scand J Surg 2018 Dec 6:1457496918816927. Epub 2018 Dec 6.

1  Department of Surgery, Dr George Mukhari Academic Hospital, Sefako Makgatho Health Sciences University, Pretoria, South Africa.

Background And Aims:: Laparoscopy in blunt abdominal trauma is challenging because of multiple associated injuries, higher trauma score values and higher morbidity and mortality, as compared with patients with penetrating abdominal trauma. The aim of this study was to investigate the role of laparoscopy in the management of blunt abdominal trauma patients and to highlight related challenges.

Material And Methods:: Over a 4-year period, patients managed laparoscopically for blunt abdominal trauma were retrospectively analyzed. Read More

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December 2018

En-Bloc Excision of the High-ligated Inferior Mesenteric Vein Pedicle With the Specimen in Patients Undergoing Minimally Invasive and Open Sphincter Saving Rectal Resections for Cancer.

Surg Laparosc Endosc Percutan Tech 2018 Dec 11. Epub 2018 Dec 11.

Departments of General Surgery.

Although high-ligated pedicle of the inferior mesenteric artery is usually kept in the resected specimens, the value of preserving high-ligated pedicle of the inferior mesenteric vein within the resected specimens of the sphincter saving rectal resections for cancer is not well defined. In the current study, patients undergoing open, laparoscopic, and robotic sphincter saving rectal resection for cancer were prospectively included. Lymph node invasion and presence of lymph nodes along the IMV pedicles were analyzed. Read More

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December 2018
1 Read

[Operative treatment of acute mesenteric ischaemia].

Magy Seb 2018 Dec;71(4):149-154

Általános, Ér- és Plasztikai Sebészeti Osztály, Markusovszky Egyetemi Oktatókórház 9700 Szombathely, Markusovszky Lajos u. 5.

Introduction: The incidence of acute mesenteric ischemia (AMI) appears to be increasing due to aging in the population with increasing prevalence of comorbidities. Despite the wide-scale availability of diagnostic technologies, the timely detection and correct treatment are not ensured. This is due to the fact that the required CT angiography is not immediately performed and that vascular surgical reconstruction can be performed within the short ischemic tolerance window of the bowels amounting 4-6 hours. Read More

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December 2018
3 Reads

ANATOMICAL VARIATIONS OF THE CELIAC TRUNK: A SYSTEMATIC REVIEW.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1403. Epub 2018 Dec 6.

University Center UNIFACISA), João Pessoa, PB.

Introduction: The celiac trunk (CT) is one of the abdominal portion branches of the aortic artery and, together with the superior mesenteric and inferior mesenteric arteries, participates in the abdominal viscera vascularization through a series of anastomoses. Absence of CT or variation in the number of terminal branches implies in varied abdominal arteries origins, which may have implication in surgical approaches.

Objective: To analyze the anatomical variations of the celiac trunk and possible associated surgical clinical implications. Read More

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December 2018

Pancreaticoduodenectomy with Mesocaval Shunt for Locally Advanced Pancreatic Adenocarcinoma.

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler, Unit 1484, Houston, TX, USA.

Introduction: Patients with locally advanced pancreatic cancer (LAPC) represent a challenging group to treat, given the involvement of major vascular structures. In selected patients with favorable biology, temporary mesocaval shunt can facilitate the resection and allow for a safer procedure with enhanced exposure to the superior mesenteric vessels.

Methods: We present a video of a pancreaticoduodenectomy (PD) with temporary mesocaval shunt with left internal jugular (LIJ) vein conduit. Read More

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December 2018

IL-33 Protects Mice against DSS-Induced Chronic Colitis by Increasing Both Regulatory B Cell and Regulatory T Cell Responses as Well as Decreasing Th17 Cell Response.

J Immunol Res 2018 13;2018:1827901. Epub 2018 Nov 13.

Life Science School, Liaoning University, Shenyang 110036, China.

Background: Previously, we have reported that IL-33 functioned as a protective modulator in dextran sulfate sodium- (DSS-) induced chronic colitis by suppressing Th17 cell response in colon lamina propria and IL-33 induced both regulatory B cells (Bregs) and regulatory T cells (Tregs) in mesenteric lymph nodes (MLNs) of mice with DSS-induced acute colitis. Moreover, we speculated that IL-33 would promote the Treg or Breg responses leading to the attenuation of DSS-induced chronic colitis. So, we investigated the role of IL-33 on Bregs and Tregs in the MLN of DSS-induced chronic colitis mice. Read More

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November 2018

Interactions Between Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy.

Front Oncol 2018 27;8:553. Epub 2018 Nov 27.

College of Engineering, Mathematics and Physical Sciences, Department of Physics and Astronomy, University of Exeter, Exeter, United Kingdom.

Acute Lymphoblastic Leukemia (ALL) remains the most frequent cause of cancer-related mortality in children and novel therapies are needed for the treatment of relapsed/refractory childhood ALL. One approach is the targeting of ALL blasts with the immunotoxin CAT-8015. Although CAT-8015 has potent anti-leukemia activity, with a 32% objective response rate in a phase 1 study of childhood ALL, haemolytic-uremic syndrome (HUS) and vascular leak syndrome (VLS), major dose-limiting toxicities, have limited the use of this therapeutic approach in children. Read More

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November 2018

Oral Antibiotics Reduce Intestinal Necrosis in Acute Mesenteric Ischemia: A Prospective Cohort Study.

Am J Gastroenterol 2018 Dec 11. Epub 2018 Dec 11.

APHP, Department of Gastroenterology, IBD and Intestinal Failure, Beaujon Hospital, 92110, Clichy, France.

Objectives: To identify treatments likely to prevent progression towards irreversible transmural intestinal necrosis (ITIN) in acute mesenteric ischemia (AMI).

Methods: Prospective observational cohort study from a French intestinal stroke center. Multivariate analysis using a time-dependent Cox regression model. Read More

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December 2018

Acute mesenteric venous thrombosis in a pregnant woman at 35 weeks of gestation: a case report and review of the literature.

BMC Pregnancy Childbirth 2018 Dec 11;18(1):487. Epub 2018 Dec 11.

Department of Obstetrics and Gynecology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.

Background: Mesenteric venous thrombosis (MVT) is an infrequent thrombotic event that can cause devastating intestinal hemorrhagic ischemia. The mortality rate among patients with acute MVT ranges from 20 to 50%. Occurrence of MVT in pregnancy is quite rare. Read More

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December 2018

Pathological analyses of very long-term sirolimus-eluting stent implantation in human coronary artery.

J Cardiol Cases 2013 Nov 26;8(5):145-147. Epub 2013 Sep 26.

Kokura Memorial Hospital, Kokura, Japan.

A 73-year-old man underwent sirolimus-eluting stent (SES) implantation for chest pain on exertion with left anterior descending coronary artery (LAD) and left circumflex coronary artery (LCX). The patient died due to non-obstructive mesenteric ischemia after 57 months of SES implantation. An autopsy demonstrated that the lesions of stented site at LAD and LCX were histopathologicaly similar images. Read More

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November 2013

Successful stenting to superior mesenteric artery (SMA) after endovascular aneurysm repair (EVAR) of abdominal aorta.

J Cardiol Cases 2010 Oct 6;2(2):e78-e82. Epub 2010 May 6.

Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center 5-3-1 Chikami, Kumamoto-city, 861-4193, Japan.

A 70-year-old man complained of abdominal angina after endovascular aneurysm repair (EVAR). He had a history of successful treatment of abdominal aortic aneurysm with Zenith endovascular graft 12 months prior to the index abdominal symptoms. The endovascular graft had been placed with special attention for keeping blood flow of major abdominal branches to the intestine. Read More

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October 2010

[Endovascular Therapy of Splanchnic Artery Aneurysms: For Each and Every Aneurysm?]

Zentralbl Chir 2018 Dec 11. Epub 2018 Dec 11.

Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Jena, Deutschland.

True visceral artery aneurysms (VAA) and visceral artery pseudoaneurysms (VAPA) are located in the celiac trunk, the superior mesenteric artery and inferior mesenteric artery. In addition to surgical treatment, endovascular embolisation therapy of visceral aneurysms and pseudoaneurysms is an alternative interventional method that has developed precipitously over the last two decades and is considered a first-choice method in many centres. The procedure is characterised by a high technical success rate with a low complication rate. Read More

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December 2018
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Acute mesenteric ischaemia: A case of expedited diagnosis and management using point-of-care ultrasound.

Afr J Emerg Med 2018 Dec 2;8(4):164-166. Epub 2018 Oct 2.

Department of Emergency Medicine, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA.

Introduction: The term refers to a clinical syndrome of sudden onset, severe abdominal pain. The differential diagnosis for this presentation is broad, but most cases require emergent medical or surgical management. Especially in cases of ischaemic bowel, time to diagnosis can mean the difference between survival and death. Read More

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December 2018

[A case of jejunal neuroendocrine carcinoma complicated with dermatomyositis].

Nihon Shokakibyo Gakkai Zasshi 2018 ;115(12):1063-1068

Department of Medical Oncology, Shizuoka General Hospital.

A 65-year-old woman who had been diagnosed with dermatomyositis presented to the hospital with a small bowel mass. She had tested positive for fecal occult blood test and anemia at a medical checkup;therefore, computerized tomography (CT) was performed at the previous hospital and it had revealed thickening of the intestinal wall. Abdominal contrast-enhanced CT, single-balloon assisted enteroscopy, and biopsy led to a diagnosis of poorly differentiated jejunal adenocarcinoma. Read More

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January 2018

IL-33 Induces Murine Intestinal Goblet Cell Differentiation Indirectly via Innate Lymphoid Cell IL-13 Secretion.

J Immunol 2018 Dec 7. Epub 2018 Dec 7.

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229;

Regulation of the intestinal mucus layer by goblet cells is important for preventing inflammation and controlling infection. IL-33, a cytokine upregulated in inflammatory bowel disease and helminth infection, induces intestinal goblet cells, but the mechanism remains unclear. Enteroids are three-dimensional structures of primary small intestinal epithelial cells that contain all differentiated intestinal epithelial cell types. Read More

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December 2018

Outcomes of endovascular treatments for in-stent restenosis in patients with mesenteric atherosclerotic disease.

J Vasc Surg 2018 Oct 24. Epub 2018 Oct 24.

Department of Endovascular and Vascular Surgery, Geisinger Medical Center, Danville, Pa.

Objective: Mesenteric angioplasty and stenting (MAS) has surpassed open revascularization as the treatment of choice for mesenteric ischemia. Despite the lower perioperative mortality associated with MAS, the need for reintervention is not infrequent. The purpose of this study was to review the outcomes of patients treated for mesenteric artery in-stent restenosis (MAISR). Read More

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October 2018

Major complications of jejunal feeding in children.

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Department of Paediatric Surgery, Royal Hospital for Sick Children, Edinburgh, UK. Electronic address:

Aim Of The Study: The aim of the study was to identify major gastrointestinal complications associated with direct jejunal feeding. We hypothesized that jejunal feeding may cause life-threatening surgical complications in a minority of patients.

Methods: All patients undergoing jejunal feeding between 1/2008 and 1/2018 at a pediatric surgical unit were identified retrospectively. Read More

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November 2018

Mechanical Thrombectomy Using the Solitaire AB Device for Acute Embolic Mesenteric Ischemia.

J Vasc Interv Radiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Vascular and Interventional Radiology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, China. Electronic address:

Purpose: To review preliminary efficacy and safety outcomes of mechanical thrombectomy using the Solitaire AB device combined with thromboaspiration for treatment of acute embolic occlusion of the superior mesenteric artery (SMA).

Materials And Methods: Between October 2015 and October 2017, 9 patients (average age, 77 y; range, 62-84 y) presenting with acute mesenteric ischemia attributable to embolic occlusion at the stem of the SMA were retrospectively evaluated for mechanical thrombectomy using the Solitaire AB device combined with manual thromboaspiration. Adjunctive stent implantation was performed to correct pre-existing atherosclerotic stenosis or as a rapid recanalization solution after unsuccessful thrombectomy. Read More

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December 2018

Effect of Hyperbilirubinemia on Hepatic Hypertrophy after Portal Vein Embolization and Liver Failure after Heatectomy in Primary Biliary Malignancy.

J Vasc Interv Radiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiology, Kyungpook National University School of Medicine, Daegu, Korea.

Purpose: To retrospectively investigate the impact of hyperbilirubinemia on future liver remnant (FLR) volume after percutaneous transhepatic portal vein embolization (PVE) and incidence of post-hepatectomy liver failure in primary biliary malignancy.

Materials And Methods: Eighty-seven patients (62 men, overall mean age 66.9 y) who underwent PVE, using Gelfoam and coils before major hepatectomy between January 2004 and June 2016, were included in this study and divided into a hyperbilirubinemia (serum total bilirubin level at PVE 5. Read More

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December 2018

Hydrogen Sulfide Donor GYY4137 Acts Through Endothelial Nitric Oxide to Protect Intestine in Murine Models of Necrotizing Enterocolitis and Intestinal Ischemia.

J Surg Res 2019 Feb 23;234:294-302. Epub 2018 Oct 23.

Department of Surgery, Section of Pediatric Surgery, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana; Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

Background: Necrotizing enterocolitis (NEC) in premature infants is often a devastating surgical condition with poor outcomes. GYY4137 is a long-acting donor of hydrogen sulfide, a gasotransmitter that is protective against intestinal injury in experimental NEC, likely through protection against injury secondary to ischemia. We hypothesized that administration of GYY4137 would improve mesenteric perfusion, reduce intestinal injury, and reduce inflammatory responses in experimental NEC and ischemia-reperfusion injury, and that these benefits would be mediated through endothelial nitric oxide synthase-dependent pathways. Read More

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February 2019

Hydrogen peroxide constricts rat arteries by activating Na-permeable and Ca-permeable cation channels.

Free Radic Res 2018 Dec 10:1-171. Epub 2018 Dec 10.

b Department of Emergency Medical Services , Eulji University , Seongnam , Republic of Korea.

Oxidative stress is associated with many cardiovascular diseases, such as hypertension and arteriosclerosis. Oxidative stress reportedly activates the L-type voltage-gated calcium channel (VDCC) and elevates [Ca] in many cells. However, how oxidative stress activates VDCC under clinical setting and the consequence for arteries are unclear. Read More

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December 2018

Dietary Prevention of Colitis by Aronia Berry is Mediated Through Increased Th17 and Treg.

Mol Nutr Food Res 2018 Dec 6:e1800985. Epub 2018 Dec 6.

Department of Food Science, University of Wisconsin-Madison, Madison, WI, 53706, USA.

Scope: Increased fruit consumption is associated with reduced risk of colitis. It has been investigated whether the anti-colitic effects of the polyphenol-rich aronia berry (Aronia mitschurinii 'Viking') are mediated through Th17 and Treg.

Methods And Results: Colitis is induced in recombinase activating gene-1 deficient mice injected with syngeneic CD4 CD62L naïve T cells. Read More

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December 2018
3 Reads

Diagnostic laparoscopy to investigate unexplained lactic acidosis in critically ill patients - A descriptive single centre cohort study.

Ann Med Surg (Lond) 2018 Dec 13;36:231-234. Epub 2018 Nov 13.

Department of Surgery, University Hospital Hairmyres, NHS Lanarkshire, East Kilbride, G75 8RG, Scotland, UK.

Introduction: Unexplained lactic acidosis (LA) in a critically ill patient often prompts investigations to rule out any reversible intra-abdominal cause. Equivocal results can lead to an emergency laparotomy (EL) with subsequent high morbidity and mortality rates. Our objective was to determine the clinical impact of urgent diagnostic laparoscopy (UDL) in such patients. Read More

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December 2018
2 Reads

Sugar Metabolism Regulates Flavor Preferences and Portal Glucose Sensing.

Front Integr Neurosci 2018 21;12:57. Epub 2018 Nov 21.

The John B. Pierce Laboratory, Yale University, New Haven, CT, United States.

In most species, including humans, food preference is primarily controlled by nutrient value. In particular, glucose-containing sugars exert exquisitely strong effects on food choice via gut-generated signals. However, the identity of the visceral signals underlying glucose's rewarding effects remains uncertain. Read More

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November 2018
2 Reads

Oral vaccination with Trichinella spiralis DNase II DNA vaccine delivered by attenuated Salmonella induces a protective immunity in BALB/c mice.

Vet Res 2018 Dec 5;49(1):119. Epub 2018 Dec 5.

Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.

Trichinellosis is one of the most serious foodborne parasitic zoonosis with worldwide distribution, and it is necessary to develop a vaccine to interrupt transmission from animals to humans. Trichinella spiralis adult-specific DNase II-1 (TsDNase II) were identified by immunoproteomics in surface or excretory/secretory proteins of adult worms (AW) and intestinal infective larvae (IIL). The aim of this study was to investigate the systemic, mucosal responses and immune protection elicited by oral vaccination with TsDNase II DNA vaccine delivered by attenuated Salmonella typhimurium strain⊿cyaSL1344. Read More

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December 2018
1 Read
2.815 Impact Factor

The composition of a bioprocessed shiitake (Lentinus edodes) mushroom mycelia and rice bran formulation and its antimicrobial effects against Salmonella enterica subsp. enterica serovar Typhimurium strain SL1344 in macrophage cells and in mice.

BMC Complement Altern Med 2018 Dec 5;18(1):322. Epub 2018 Dec 5.

Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, CA, 94710, USA.

Background: Human infection by pathogenic Salmonella bacteria can be acquired by consuming of undercooked meat products and eggs. Antimicrobial resistance against antibiotics used in medicine is also a major concern. To help overcome these harmful effects on microbial food safety and human health, we are developing novel antimicrobial food-compatible formulations, one of which is described in the present study. Read More

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December 2018
3 Reads

Synthesis and biological evaluation of novel biphenyl-furocoumarin derivatives as vasodilator agents.

J Asian Nat Prod Res 2018 Dec 3:1-14. Epub 2018 Dec 3.

a School of Pharmacy, Xi'an Jiaotong University , Xi'an 710061 , China.

A series of novel biphenyl-furocoumarin derivatives were synthesized based on the nuclear structure of imperatorin and identified by IR, H NMR, C NMR and MS, and evaluated for their ability to relax vessel on isolated rat mesenteric artery, basilar artery and renal artery, respectively. The majority of compounds demonstrated potent vasodilatation, and compound 8e expressed the highest activity (EC = 0.56 μM) in MA. Read More

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December 2018
1 Read

[Histological study on the safety of the controllable ileostomy with pipe].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1291-1295

Department of Gastrointestinal Surgery, Provincial Clinical College, Fujian Medical University, Fuzhou 350001, China.

Objective: To investigate the safety of the controllable ileostomy with pipe in view of histology.

Methods: Twenty-eight Beagle dogs undergoing controllable ileostomy with pipe were studied. The special fistula tube with balloon was placed into the hole locating at the cecal root opposing the mesenteric side, and fixed by double knot compression method. Read More

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November 2018
4 Reads

Short-term changes observed in multiparametric liver MRI following therapy with direct-acting antivirals in chronic hepatitis C virus patients.

Eur Radiol 2018 Nov 30. Epub 2018 Nov 30.

Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK.

Methods: We applied multiparametric MRI to assess changes in liver composition, perfusion and blood flow in 17 patients before direct-acting antiviral (DAA) therapy and after treatment completion (within 12 weeks of last DAA tablet swallowed).

Results: We observed changes in hepatic composition indicated by a reduction in both liver longitudinal relaxation time (T1, 35 ± 4 ms), transverse relaxation time (T2, 2.5 ± 0. Read More

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November 2018
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Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells.

Acta Pharm Sin B 2018 Oct 26;8(6):909-918. Epub 2018 Jul 26.

Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150086, China.

Our previous studies found that mitochondrial uncouplers CCCP and niclosamide inhibited artery constriction and the mechanism involved AMPK activation in vascular smooth muscle cells. BAM15 is a novel type of mitochondrial uncoupler. The aim of the present study is to identify the vasoactivity of BAM15 and characterize the BAM15-induced AMPK activation in vascular smooth muscle cells (A10 cells). Read More

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October 2018
2 Reads

Gamma-Aminobutyric Acid (GABA) Attenuates Ischemia Reperfusion-Induced Alterations in Intestinal Immunity.

Biol Pharm Bull 2018 ;41(12):1874-1878

Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University.

The aims of this study were to determine the effects of gamma-aminobutyric acid (GABA) on immunoglobulin A (IgA) secretion from Peyer's patch (PP) cells; to assess rat alpha-defensin-5 (RD-5) expression in the rat small intestine; and to determine the effect of GABA on intestinal ischemia reperfusion (I/R) injury-induced intestinal innate immunity. We found that GABA caused an increase in IgA secretion in the presence and absence of lipopolysaccharide (LPS). Moreover, GABA also significantly increased the mRNA levels of RD-5 and superoxide dismutase (Sod) 1, 3. Read More

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January 2018
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Protein-Losing Enteropathy and Plastic Bronchitis After the Fontan Operation.

Authors:
Christine Peyton

Crit Care Nurse 2018 Dec;38(6):e5-e12

Christine Peyton is a clinical nurse specialist at the Heart Institute at Children's Hospital Colorado, Aurora, Colorado.

Protein-losing enteropathy and plastic bronchitis remain challenging to treat despite recent treatment advances. Protein-losing enteropathy and plastic bronchitis have been diagnosed in patients with cardiomyopathy, constrictive pericarditis, and congestive heart failure. This article focuses on patients with protein-losing enteropathy or plastic bronchitis following the Fontan procedure. Read More

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December 2018
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Intrauterine volvulus that had been misunderstood as an antenatal mesenteric cyst.

Pediatr Neonatol 2018 Sep 4. Epub 2018 Sep 4.

Necmettin Erbakan University, Meram Medical Faculty, Department of Pediatrics, Division of Neonatology, Meram, Konya, Turkey.

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September 2018
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Mesenteric venous thrombosis presenting as gastrointestinal bleeding, a challenging diagnosis: Review and case report.

Am J Emerg Med 2018 Nov 7. Epub 2018 Nov 7.

Department of Emergency Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Acute mesenteric venous thrombosis (MVT) is an uncommon cause of intestinal ischemia and is associated with high morbidity and mortality. Patients with acute MVT often present with gastrointestinal (GI) bleeding and other unspecific findings making the diagnosis challenging. This condition requires emergent treatment. Read More

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November 2018
1 Read