63,228 results match your criteria Mesenteric Ischemia
Int J Surg Case Rep 2018 Nov 27;54:83-86. Epub 2018 Nov 27.
Department of Gastroenterological Surgery, Higashiosaka City Medical Center, Nishiiwata 3-4-5, Higashiosaka, Osaka, 567-8588, Japan.
Introduction: Enteric duplication cysts are rare and, in addition, isolated enteric duplication cysts are lower morbidity prevalence rate. These cysts lack a connection to the gastrointestinal tract or the adjacent mesenteric vasculature and have only been reported in 10 case reports. In these reports, only two reports were cases with malignant transformation. Read More
Surg Radiol Anat 2018 Dec 14. Epub 2018 Dec 14.
Department of Anatomy and Surgical Anatomy, School of Medicine, National and Kapodistrian University of Athens, Tetrapoleos 18, 75 Mikras Asias Str, 11527, Athens, Greece.
Purpose: The arc of Bühler, an anastomotic vessel between celiac artery and superior mesenteric artery, is a rare anatomic variation. Various radiologic and surgical procedures can be affected by its existence. We aim to review all available information and identify possible clinical implications. Read More
Biomed Pharmacother 2019 Jan 30;109:2396-2408. Epub 2018 Nov 30.
Department of Cardiology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China.
Objective: Compound sophorae decoction, a Chinese medicinal formulae composed of six Chinese herbs, is effective for the clinical treatment of ulcerative colitis (UC). Some of its effective monomers had been proven to have suppressive effect on UC models. The aim of this study is to further explore the mechanism whether compound sophorae decoction ameliorates dextran sodium sulfate (DSS)-induced mice colitis by regulating the balance between T helper (Th) 17 and regulatory T (Treg) cells. Read More
Physiol Rep 2018 Dec;6(23):e13920
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
In tauopathies, such as Alzheimer's disease with or without concomitant amyloid β plaques, cerebral arteries display pathological remodeling, leading to reduced brain tissue oxygenation and cognitive impairment. The precise mechanisms that underlie this vascular dysfunction remain unclear. Kv7 voltage-dependent K channels contribute to the development of myogenic tone in rat cerebral arteries. Read More
J Endovasc Ther 2018 Dec 14:1526602818815821. Epub 2018 Dec 14.
1 Department of Vascular Surgery, Zhongshan Hospital Fudan University, Shanghai, China.
Purpose: To describe endovascular treatment of mesenteric malperfusion in a multichannel aortic dissection (MCAD) with full true lumen (TL) collapse following thoracic endovascular aortic repair (TEVAR).
Case Report: A 54-year-old man presented with chronic mesenteric ischemia and a previous TEVAR for MCAD complicated by superior mesenteric artery (SMA) malperfusion. Computed tomography angiography (CTA) demonstrated a 3-channel aortic dissection with a "false-true-false" configuration. Read More
Mol Clin Oncol 2018 Dec 5;9(6):661-665. Epub 2018 Oct 5.
Department of Pathology, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo 113-0021, Japan.
Primary gastric undifferentiated pleomorphic sarcoma (UPS) is a rare disease with insufficient long-term follow-up data. In the present study, a 70-year-old male complained of abdominal fullness and visited our hospital. Abdominal computed tomography revealed a large tumor in the upper part of the stomach, which was accompanied by smaller tumors in the small intestinal mesentery. Read More
Int J Obes (Lond) 2018 Dec 13. Epub 2018 Dec 13.
Department of Biochemistry and Molecular Biology, LSUHSC School of Medicine, New Orleans, LA, 70112, USA.
Background/objectives: NISCH-STAB1 is a newly identified locus correlated to human waist-hip ratio (WHR), which is a risk indicator of developing obesity-associated diabetes. Our previous studies have shown that Nisch mutant male mice increased glucose tolerance in chow-fed conditions. Thus we hypothesized that Nisch mutant mice will have changes in insulin resistance, adipocytes, hepatic steatosis when mice are fed with high-fat diet (HFD). Read More
Int J Mol Sci 2018 Dec 7;19(12). Epub 2018 Dec 7.
Unit of Cardiology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm 17176, Sweden.
Purinergic signaling may be altered in diabetes accounting for endothelial dysfunction. Uridine adenosine tetraphosphate (Up₄A), a novel dinucleotide substance, regulates vascular function via both purinergic P1 and P2 receptors (PR). Up₄A enhances vascular contraction in isolated arteries of diabetic rats likely through P2R. Read More
Eur Surg Res 2018 Dec 13;59(5-6):371-379. Epub 2018 Dec 13.
The progression of colon cancer (CC) involves hematogenous and lymphatic spread to locoregional lymph nodes (LN), distant LN, and metastatic sites including the liver. The biological mechanisms that govern CC progression remain elusive. The Halsted model assumes an orderly, stepwise progression from the primary tumor to nearby nodes, henceforth to anatomically more distant nodes, and ultimately to distant organs. Read More
J Int Med Res 2018 Dec 13:300060518814682. Epub 2018 Dec 13.
Department of General, Visceral and Transplant Surgery, University Medical Center of Johannes Gutenberg University, Mainz, Germany.
We report a case of a 69-year-old patient with esophageal cancer and severe upper gastrointestinal bleeding during neoadjuvant radiochemotherapy who required mass transfusion followed by complex emergency procedures. Despite endoscopic stenting, the bleeding recurred, and thus emergency open surgery was required. Gastric wedge resection of the minor curvature necessitated by perforation caused by the endoscopic stent maneuver and duodenotomy with ligation of the gastroduodenal artery, as the cause of persistent intraluminal bleeding, were performed. Read More
World J Surg 2018 Dec 12. Epub 2018 Dec 12.
Division of Colorectal Surgery, Department of Surgery, National Taiwan University Hospital and College of Medicine, No. 7, Chung-Shan South Road, Taipei, Taiwan, ROC.
Background: The present study is to set up a standardized approach for complete mobilization of colonic splenic flexure using da Vinci Xi robotic system, based on clarification of the mesenteric structures of distal transverse colon.
Methods: The surgical outcomes and relevant anatomic structures of 104 consecutive patients undergoing robotic resection of primary colorectal cancer with the intent of complete mobilization of colonic splenic flexure using da Vinci Xi robotic system were retrospectively reviewed.
Results: Complete mobilization of colonic splenic flexure can be efficiently performed by the Xi robotic system, as demonstrated by short operation time, minimal intra-operative blood loss, and few surgical complications. Read More
Turk J Med Sci 2018 12 12;48(6):1214-1218. Epub 2018 Dec 12.
Department of Radiology, Faculty of Medicine, Fırat University, Elazığ, Turkey
Background/aim: This study aims to evaluate the incidence and multidetector computed tomography (MDCT) findings of median
arcuate ligament syndrome (MALS).
Materials And Methods: Between January 2010 and September 2016 a total of 4028 patients who underwent angiography for MDCT
based on the clinical indications for abdominal pain were retrospectively analyzed.
Results: The typical signs of MALS were identified in a total of 141 (3. Read More
Trop Anim Health Prod 2018 Dec 6. Epub 2018 Dec 6.
Young Researchers and Elite Club, Zabol Branch, Islamic Azad University, Zabol, Iran.
This research was conducted to determine the prevalence and intensity of infection with nymphs of Linguatula serrata in mesenteric lymph nodes of the goats from northwest of Iran. Moreover, the intensity of infection of mesenteric lymph nodes was compared based on gross appearance and the morphological changes in these nodes. In addition, the effects of age, sex, and season on the prevalence of Linguatula serrata were assessed. Read More
Pharm Res 2018 Dec 6;36(1):23. Epub 2018 Dec 6.
Technical Research Center, KOBELCO Eco-Solutions Co., Ltd., 1-1-4 Murotani, Kobe, Hyogo, 651-2241, Japan.
Purpose: Straight-chain polysaccharides have a greater potential of selectively adsorbing hydrophobic bile salts than resin-based bile salt sequesters because of ionic and hydrophobic interactions; hence, they may possess antidiabetic activity. The feasibility of using cationic polysaccharides made from euglenoid β-1,3-glucan (referred to as paramylon) as potential antidiabetic agents was examined by using in vitro and animal experiments.
Methods: Cationic straight-chain polysaccharides were synthesized from euglenoid polysaccharide and glycidyltrimethylammonium chloride. Read More
Mucosal Immunol 2018 Dec 6. Epub 2018 Dec 6.
Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, 10032, USA.
Defining adaptive immunity with the complex structures of the human gastrointestinal (GI) tract over life is essential for understanding immune responses to ingested antigens, commensal and pathogenic microorganisms, and dysfunctions in disease. We present here an analysis of lymphocyte localization and T cell subset composition across the human GI tract including mucosal sites (jejunum, ileum, colon), gut-associated lymphoid tissues (isolated lymphoid follicles (ILFs), Peyer's patches (PPs), appendix), and mesenteric lymph nodes (MLNs) from a total of 68 donors spanning eight decades of life. In pediatric donors, ILFs and PP containing naïve T cells and regulatory T cells (Tregs) are prevalent in the jejunum and ileum, respectively; these decline in frequency with age, contrasting stable frequencies of ILFs and T cell subsets in the colon. Read More
Asian J Surg 2018 Dec 3. Epub 2018 Dec 3.
Division of Colorectal Surgery, Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
To clarify the anatomic concept of Toldt fascia, based on the literature review and the surgical anatomic dissection using laparoscopic or robotic approach. We undertook review of the historic literature and surgical videos from 250 patients with colorectal cancer operated on laparoscopically or robotically to discuss the surgical implications of Toldt fascia in complete mesocolic excision for colon cancer. Toldt fascia, sandwiched by the overlying mesothelial layer of the mesocolon and underlying mesothelial layer of the retroperitoneum, comprised loose fibrous tissues with minute vessels inside, and was contiguous from the ileocecal mesentery radix to the upper rectum. Read More
Scand J Surg 2018 Dec 6:1457496918816927. Epub 2018 Dec 6.
1 Department of Surgery, Dr George Mukhari Academic Hospital, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
Background And Aims:: Laparoscopy in blunt abdominal trauma is challenging because of multiple associated injuries, higher trauma score values and higher morbidity and mortality, as compared with patients with penetrating abdominal trauma. The aim of this study was to investigate the role of laparoscopy in the management of blunt abdominal trauma patients and to highlight related challenges.
Material And Methods:: Over a 4-year period, patients managed laparoscopically for blunt abdominal trauma were retrospectively analyzed. Read More
Surg Laparosc Endosc Percutan Tech 2018 Dec 11. Epub 2018 Dec 11.
Departments of General Surgery.
Although high-ligated pedicle of the inferior mesenteric artery is usually kept in the resected specimens, the value of preserving high-ligated pedicle of the inferior mesenteric vein within the resected specimens of the sphincter saving rectal resections for cancer is not well defined. In the current study, patients undergoing open, laparoscopic, and robotic sphincter saving rectal resection for cancer were prospectively included. Lymph node invasion and presence of lymph nodes along the IMV pedicles were analyzed. Read More
Magy Seb 2018 Dec;71(4):149-154
Általános, Ér- és Plasztikai Sebészeti Osztály, Markusovszky Egyetemi Oktatókórház 9700 Szombathely, Markusovszky Lajos u. 5.
Introduction: The incidence of acute mesenteric ischemia (AMI) appears to be increasing due to aging in the population with increasing prevalence of comorbidities. Despite the wide-scale availability of diagnostic technologies, the timely detection and correct treatment are not ensured. This is due to the fact that the required CT angiography is not immediately performed and that vascular surgical reconstruction can be performed within the short ischemic tolerance window of the bowels amounting 4-6 hours. Read More
Arq Bras Cir Dig 2018 Dec 6;31(4):e1403. Epub 2018 Dec 6.
University Center UNIFACISA), João Pessoa, PB.
Introduction: The celiac trunk (CT) is one of the abdominal portion branches of the aortic artery and, together with the superior mesenteric and inferior mesenteric arteries, participates in the abdominal viscera vascularization through a series of anastomoses. Absence of CT or variation in the number of terminal branches implies in varied abdominal arteries origins, which may have implication in surgical approaches.
Objective: To analyze the anatomical variations of the celiac trunk and possible associated surgical clinical implications. Read More
Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler, Unit 1484, Houston, TX, USA.
Introduction: Patients with locally advanced pancreatic cancer (LAPC) represent a challenging group to treat, given the involvement of major vascular structures. In selected patients with favorable biology, temporary mesocaval shunt can facilitate the resection and allow for a safer procedure with enhanced exposure to the superior mesenteric vessels.
Methods: We present a video of a pancreaticoduodenectomy (PD) with temporary mesocaval shunt with left internal jugular (LIJ) vein conduit. Read More
J Immunol Res 2018 13;2018:1827901. Epub 2018 Nov 13.
Life Science School, Liaoning University, Shenyang 110036, China.
Background: Previously, we have reported that IL-33 functioned as a protective modulator in dextran sulfate sodium- (DSS-) induced chronic colitis by suppressing Th17 cell response in colon lamina propria and IL-33 induced both regulatory B cells (Bregs) and regulatory T cells (Tregs) in mesenteric lymph nodes (MLNs) of mice with DSS-induced acute colitis. Moreover, we speculated that IL-33 would promote the Treg or Breg responses leading to the attenuation of DSS-induced chronic colitis. So, we investigated the role of IL-33 on Bregs and Tregs in the MLN of DSS-induced chronic colitis mice. Read More
Front Oncol 2018 27;8:553. Epub 2018 Nov 27.
College of Engineering, Mathematics and Physical Sciences, Department of Physics and Astronomy, University of Exeter, Exeter, United Kingdom.
Acute Lymphoblastic Leukemia (ALL) remains the most frequent cause of cancer-related mortality in children and novel therapies are needed for the treatment of relapsed/refractory childhood ALL. One approach is the targeting of ALL blasts with the immunotoxin CAT-8015. Although CAT-8015 has potent anti-leukemia activity, with a 32% objective response rate in a phase 1 study of childhood ALL, haemolytic-uremic syndrome (HUS) and vascular leak syndrome (VLS), major dose-limiting toxicities, have limited the use of this therapeutic approach in children. Read More
Am J Gastroenterol 2018 Dec 11. Epub 2018 Dec 11.
APHP, Department of Gastroenterology, IBD and Intestinal Failure, Beaujon Hospital, 92110, Clichy, France.
Objectives: To identify treatments likely to prevent progression towards irreversible transmural intestinal necrosis (ITIN) in acute mesenteric ischemia (AMI).
Methods: Prospective observational cohort study from a French intestinal stroke center. Multivariate analysis using a time-dependent Cox regression model. Read More
BMC Pregnancy Childbirth 2018 Dec 11;18(1):487. Epub 2018 Dec 11.
Department of Obstetrics and Gynecology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Background: Mesenteric venous thrombosis (MVT) is an infrequent thrombotic event that can cause devastating intestinal hemorrhagic ischemia. The mortality rate among patients with acute MVT ranges from 20 to 50%. Occurrence of MVT in pregnancy is quite rare. Read More
Zentralbl Chir 2018 Dec 11. Epub 2018 Dec 11.
Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Jena, Deutschland.
True visceral artery aneurysms (VAA) and visceral artery pseudoaneurysms (VAPA) are located in the celiac trunk, the superior mesenteric artery and inferior mesenteric artery. In addition to surgical treatment, endovascular embolisation therapy of visceral aneurysms and pseudoaneurysms is an alternative interventional method that has developed precipitously over the last two decades and is considered a first-choice method in many centres. The procedure is characterised by a high technical success rate with a low complication rate. Read More
Afr J Emerg Med 2018 Dec 2;8(4):164-166. Epub 2018 Oct 2.
Department of Emergency Medicine, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA.
Introduction: The term refers to a clinical syndrome of sudden onset, severe abdominal pain. The differential diagnosis for this presentation is broad, but most cases require emergent medical or surgical management. Especially in cases of ischaemic bowel, time to diagnosis can mean the difference between survival and death. Read More
Nihon Shokakibyo Gakkai Zasshi 2018 ;115(12):1063-1068
Department of Medical Oncology, Shizuoka General Hospital.
A 65-year-old woman who had been diagnosed with dermatomyositis presented to the hospital with a small bowel mass. She had tested positive for fecal occult blood test and anemia at a medical checkup;therefore, computerized tomography (CT) was performed at the previous hospital and it had revealed thickening of the intestinal wall. Abdominal contrast-enhanced CT, single-balloon assisted enteroscopy, and biopsy led to a diagnosis of poorly differentiated jejunal adenocarcinoma. Read More
J Immunol 2018 Dec 7. Epub 2018 Dec 7.
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229;
Regulation of the intestinal mucus layer by goblet cells is important for preventing inflammation and controlling infection. IL-33, a cytokine upregulated in inflammatory bowel disease and helminth infection, induces intestinal goblet cells, but the mechanism remains unclear. Enteroids are three-dimensional structures of primary small intestinal epithelial cells that contain all differentiated intestinal epithelial cell types. Read More
J Vasc Surg 2018 Oct 24. Epub 2018 Oct 24.
Department of Endovascular and Vascular Surgery, Geisinger Medical Center, Danville, Pa.
Objective: Mesenteric angioplasty and stenting (MAS) has surpassed open revascularization as the treatment of choice for mesenteric ischemia. Despite the lower perioperative mortality associated with MAS, the need for reintervention is not infrequent. The purpose of this study was to review the outcomes of patients treated for mesenteric artery in-stent restenosis (MAISR). Read More
J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.
Department of Paediatric Surgery, Royal Hospital for Sick Children, Edinburgh, UK. Electronic address:
Aim Of The Study: The aim of the study was to identify major gastrointestinal complications associated with direct jejunal feeding. We hypothesized that jejunal feeding may cause life-threatening surgical complications in a minority of patients.
Methods: All patients undergoing jejunal feeding between 1/2008 and 1/2018 at a pediatric surgical unit were identified retrospectively. Read More
J Vasc Interv Radiol 2018 Dec 6. Epub 2018 Dec 6.
Department of Vascular and Interventional Radiology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, China. Electronic address:
Purpose: To review preliminary efficacy and safety outcomes of mechanical thrombectomy using the Solitaire AB device combined with thromboaspiration for treatment of acute embolic occlusion of the superior mesenteric artery (SMA).
Materials And Methods: Between October 2015 and October 2017, 9 patients (average age, 77 y; range, 62-84 y) presenting with acute mesenteric ischemia attributable to embolic occlusion at the stem of the SMA were retrospectively evaluated for mechanical thrombectomy using the Solitaire AB device combined with manual thromboaspiration. Adjunctive stent implantation was performed to correct pre-existing atherosclerotic stenosis or as a rapid recanalization solution after unsuccessful thrombectomy. Read More
J Vasc Interv Radiol 2018 Dec 6. Epub 2018 Dec 6.
Department of Radiology, Kyungpook National University School of Medicine, Daegu, Korea.
Purpose: To retrospectively investigate the impact of hyperbilirubinemia on future liver remnant (FLR) volume after percutaneous transhepatic portal vein embolization (PVE) and incidence of post-hepatectomy liver failure in primary biliary malignancy.
Materials And Methods: Eighty-seven patients (62 men, overall mean age 66.9 y) who underwent PVE, using Gelfoam and coils before major hepatectomy between January 2004 and June 2016, were included in this study and divided into a hyperbilirubinemia (serum total bilirubin level at PVE 5. Read More
J Surg Res 2019 Feb 23;234:294-302. Epub 2018 Oct 23.
Department of Surgery, Section of Pediatric Surgery, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana; Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:
Background: Necrotizing enterocolitis (NEC) in premature infants is often a devastating surgical condition with poor outcomes. GYY4137 is a long-acting donor of hydrogen sulfide, a gasotransmitter that is protective against intestinal injury in experimental NEC, likely through protection against injury secondary to ischemia. We hypothesized that administration of GYY4137 would improve mesenteric perfusion, reduce intestinal injury, and reduce inflammatory responses in experimental NEC and ischemia-reperfusion injury, and that these benefits would be mediated through endothelial nitric oxide synthase-dependent pathways. Read More
Free Radic Res 2018 Dec 10:1-171. Epub 2018 Dec 10.
b Department of Emergency Medical Services , Eulji University , Seongnam , Republic of Korea.
Oxidative stress is associated with many cardiovascular diseases, such as hypertension and arteriosclerosis. Oxidative stress reportedly activates the L-type voltage-gated calcium channel (VDCC) and elevates [Ca] in many cells. However, how oxidative stress activates VDCC under clinical setting and the consequence for arteries are unclear. Read More
Mol Nutr Food Res 2018 Dec 6:e1800985. Epub 2018 Dec 6.
Department of Food Science, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Scope: Increased fruit consumption is associated with reduced risk of colitis. It has been investigated whether the anti-colitic effects of the polyphenol-rich aronia berry (Aronia mitschurinii 'Viking') are mediated through Th17 and Treg.
Methods And Results: Colitis is induced in recombinase activating gene-1 deficient mice injected with syngeneic CD4 CD62L naïve T cells. Read More
Ann Med Surg (Lond) 2018 Dec 13;36:231-234. Epub 2018 Nov 13.
Department of Surgery, University Hospital Hairmyres, NHS Lanarkshire, East Kilbride, G75 8RG, Scotland, UK.
Introduction: Unexplained lactic acidosis (LA) in a critically ill patient often prompts investigations to rule out any reversible intra-abdominal cause. Equivocal results can lead to an emergency laparotomy (EL) with subsequent high morbidity and mortality rates. Our objective was to determine the clinical impact of urgent diagnostic laparoscopy (UDL) in such patients. Read More
Front Integr Neurosci 2018 21;12:57. Epub 2018 Nov 21.
The John B. Pierce Laboratory, Yale University, New Haven, CT, United States.
In most species, including humans, food preference is primarily controlled by nutrient value. In particular, glucose-containing sugars exert exquisitely strong effects on food choice via gut-generated signals. However, the identity of the visceral signals underlying glucose's rewarding effects remains uncertain. Read More
Vet Res 2018 Dec 5;49(1):119. Epub 2018 Dec 5.
Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.
Trichinellosis is one of the most serious foodborne parasitic zoonosis with worldwide distribution, and it is necessary to develop a vaccine to interrupt transmission from animals to humans. Trichinella spiralis adult-specific DNase II-1 (TsDNase II) were identified by immunoproteomics in surface or excretory/secretory proteins of adult worms (AW) and intestinal infective larvae (IIL). The aim of this study was to investigate the systemic, mucosal responses and immune protection elicited by oral vaccination with TsDNase II DNA vaccine delivered by attenuated Salmonella typhimurium strain⊿cyaSL1344. Read More
BMC Complement Altern Med 2018 Dec 5;18(1):322. Epub 2018 Dec 5.
Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, CA, 94710, USA.
Background: Human infection by pathogenic Salmonella bacteria can be acquired by consuming of undercooked meat products and eggs. Antimicrobial resistance against antibiotics used in medicine is also a major concern. To help overcome these harmful effects on microbial food safety and human health, we are developing novel antimicrobial food-compatible formulations, one of which is described in the present study. Read More
J Asian Nat Prod Res 2018 Dec 3:1-14. Epub 2018 Dec 3.
a School of Pharmacy, Xi'an Jiaotong University , Xi'an 710061 , China.
A series of novel biphenyl-furocoumarin derivatives were synthesized based on the nuclear structure of imperatorin and identified by IR, H NMR, C NMR and MS, and evaluated for their ability to relax vessel on isolated rat mesenteric artery, basilar artery and renal artery, respectively. The majority of compounds demonstrated potent vasodilatation, and compound 8e expressed the highest activity (EC = 0.56 μM) in MA. Read More
Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1291-1295
Department of Gastrointestinal Surgery, Provincial Clinical College, Fujian Medical University, Fuzhou 350001, China.
Objective: To investigate the safety of the controllable ileostomy with pipe in view of histology.
Methods: Twenty-eight Beagle dogs undergoing controllable ileostomy with pipe were studied. The special fistula tube with balloon was placed into the hole locating at the cecal root opposing the mesenteric side, and fixed by double knot compression method. Read More
Eur Radiol 2018 Nov 30. Epub 2018 Nov 30.
Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK.
Methods: We applied multiparametric MRI to assess changes in liver composition, perfusion and blood flow in 17 patients before direct-acting antiviral (DAA) therapy and after treatment completion (within 12 weeks of last DAA tablet swallowed).
Results: We observed changes in hepatic composition indicated by a reduction in both liver longitudinal relaxation time (T1, 35 ± 4 ms), transverse relaxation time (T2, 2.5 ± 0. Read More
Acta Pharm Sin B 2018 Oct 26;8(6):909-918. Epub 2018 Jul 26.
Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150086, China.
Our previous studies found that mitochondrial uncouplers CCCP and niclosamide inhibited artery constriction and the mechanism involved AMPK activation in vascular smooth muscle cells. BAM15 is a novel type of mitochondrial uncoupler. The aim of the present study is to identify the vasoactivity of BAM15 and characterize the BAM15-induced AMPK activation in vascular smooth muscle cells (A10 cells). Read More
Biol Pharm Bull 2018 ;41(12):1874-1878
Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University.
The aims of this study were to determine the effects of gamma-aminobutyric acid (GABA) on immunoglobulin A (IgA) secretion from Peyer's patch (PP) cells; to assess rat alpha-defensin-5 (RD-5) expression in the rat small intestine; and to determine the effect of GABA on intestinal ischemia reperfusion (I/R) injury-induced intestinal innate immunity. We found that GABA caused an increase in IgA secretion in the presence and absence of lipopolysaccharide (LPS). Moreover, GABA also significantly increased the mRNA levels of RD-5 and superoxide dismutase (Sod) 1, 3. Read More
Crit Care Nurse 2018 Dec;38(6):e5-e12
Christine Peyton is a clinical nurse specialist at the Heart Institute at Children's Hospital Colorado, Aurora, Colorado.
Protein-losing enteropathy and plastic bronchitis remain challenging to treat despite recent treatment advances. Protein-losing enteropathy and plastic bronchitis have been diagnosed in patients with cardiomyopathy, constrictive pericarditis, and congestive heart failure. This article focuses on patients with protein-losing enteropathy or plastic bronchitis following the Fontan procedure. Read More
Pediatr Neonatol 2018 Sep 4. Epub 2018 Sep 4.
Necmettin Erbakan University, Meram Medical Faculty, Department of Pediatrics, Division of Neonatology, Meram, Konya, Turkey.
Am J Emerg Med 2018 Nov 7. Epub 2018 Nov 7.
Department of Emergency Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:
Acute mesenteric venous thrombosis (MVT) is an uncommon cause of intestinal ischemia and is associated with high morbidity and mortality. Patients with acute MVT often present with gastrointestinal (GI) bleeding and other unspecific findings making the diagnosis challenging. This condition requires emergent treatment. Read More
Cell Stem Cell 2018 Nov 21. Epub 2018 Nov 21.
Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. Electronic address:
Human intestinal transplantation often results in long-term mixed chimerism of donor and recipient blood in transplant patients. We followed the phenotypes of chimeric peripheral blood cells in 21 patients receiving intestinal allografts over 5 years. Donor lymphocyte phenotypes suggested a contribution of hematopoietic stem and progenitor cells (HSPCs) from the graft. Read More
Ann Vasc Surg 2018 Nov 28. Epub 2018 Nov 28.
Vascular and Endovascular Surgery Unit, Deprtment of Surgery "P Stefanini", Policlinico "Umberto I", "Sapienza" University of Rome.
Objectives: Aim of this work is describing incidence and fate of type 2 endoleaks (T2EL) in a multi-centric cohort of patients treated by EVAR with Ovation device (Endologix), and compering them with a group treated by Excluder (W.L. Gore & Associates). Read More