Search Our Scientific Publications & Authors

J Vasc Surg 2019 Feb 15. Epub 2019 Feb 15.

Department of Vascular and Thoracic Surgery, Bichat Hospital, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France; SURVI (Structure d'URgences Vasculaires Intestinales)-Intestinal Stroke Center, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France; Faculté de Médecine Denis Diderot-Paris 7, Paris, France.

Objective: Acute mesenteric ischemia (AMI) is an emergent event with a high mortality rate; survivors have high rates of intestinal failure. Restoration of blood flow using endovascular or surgical revascularization is associated with better outcome in terms of survival rate and intestinal resection. Retrograde open mesenteric stenting (ROMS), which is a hybrid technique, combines two benefits: prompt blood flow restoration with an endovascular approach and inspection and resection of the small bowel. Read More

Gastroenterology 2019 Feb 13. Epub 2019 Feb 13.

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, and Fondazione Luigi Villa, Milano, Italy.

Portal vein thrombosis unrelated to solid malignancy is common in patients with cirrhosis but less frequently observed in patients without cirrhosis. Prompt diagnosis and management of acute symptomatic portal vein thrombosis are essential. Failure to detect and treat thromboses can result in mesenteric ischemia, chronic cavernous transformation, and complications of portal hypertension. Read More

Surg Case Rep 2019 Feb 15;5(1):23. Epub 2019 Feb 15.

Department of Pediatrics, Yamanashi Prefectural Central Hospital, Kofu, Japan.

Background: Non-occlusive mesenteric ischemia (NOMI) is a rare and severe pathological condition that can cause intestinal necrosis without mechanical obstruction of the mesenteric artery. NOMI often develops during the treatment of severe disease in elderly patients and mostly occurs in the intestine supplied by the superior mesenteric artery (SMA). We experienced a 12-year-old patient with NOMI that was segmentally localized in the ascending colon and rectum during encephalitis treatment. Read More

Turk J Med Sci 2019 Feb 11;49(1):11-15. Epub 2019 Feb 11.

Background/aim: Acute mesenteric ischemia (AMI), one of the gastrointestinal system complications, which occurs following cardiac surgery, is challenged in the literature with a diminished incidence of AMI by heart surgery without cardiopulmonary bypass (CPB) or with pulsatile CPB. This study aims to compare the incidence and mortality rate of mesenteric ischemia in a series of consecutive patients undergoing coronary artery bypass grafting (CABG) through on-pump and off-pump techniques.

Materials And Methods: This study included patients who underwent CABG between 1 January 2010 and 31 June 2016. Read More

J Visc Surg 2019 Feb 8. Epub 2019 Feb 8.

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.

Background: Acute mesenteric ischemia (AMI) is associated with a mortality of 60-80%. Early diagnosis and rapid treatment have a decisive influence on therapy. The aim of this study was to evaluate the prognostic value of AMI markers on mortality, in order to better anticipate the clinical course and to initiate therapeutic steps at an early stage. Read More

J Thorac Cardiovasc Surg 2018 Dec 15. Epub 2018 Dec 15.

Department of Vascular Medicine, University Heart Center Hamburg-Eppendorf, Hamburg, Germany.

Objectives: SPIDER-graft for thoracoabdominal aortic aneurysm repair avoiding thoracotomy and extracorporeal circulation was modified, enabling reimplantation of lumbar arteries to prevent spinal cord ischemia and compared with open aortic repair (control) in a pig model.

Methods: Graft implantation was performed in 7 pigs per group (75-85 kg). For SPIDER-graft (groups I and II), the infra-diaphragmatic aorta was exposed through retroperitoneal access. Read More

Crit Care Med 2019 Feb 7. Epub 2019 Feb 7.

Medical Intensive Care Unit, Hospital Saint Louis, Assistance Publique - Hôpitaux de Paris, France.

Objectives: Neutropenic enterocolitis occurs in about 5.3% of patients hospitalized for hematologic malignancies receiving chemotherapy. Data from critically ill patients with neutropenic enterocolitis are scarce. Read More

Vasc Med 2019 Feb 10:1358863X18816816. Epub 2019 Feb 10.

1 Cardiovascular Institute, Warren Alpert Medical School of Brown University, Providence, RI, USA.

There are limited contemporary data on readmission after revascularization for chronic mesenteric ischemia (CMI). This study aimed to determine the rates, reasons, predictors, and costs of 30-day readmission after endovascular or surgical revascularization for CMI. Patients with CMI discharged after endovascular or surgical revascularization during 2013 to 2014 were identified from the Nationwide Readmissions Database. Read More

Medicine (Baltimore) 2019 Feb;98(6):e14446

Department of Gastroenterology.

Background: Acute mesenteric ischemia (AMI) is a life-threatening medical condition that occurs when a sudden decreased perfusion to the intestines which leads to bowel infarction, and acute superior mesenteric artery embolism (ASMAE) is the main cause of AMI. Unfortunately, with the improvement of diagnosis and treatment technology, the mortality remains high due to less frequent clinical suspicion resulted from the unclear clinical manifestation and non-specific laboratory findings.

Methods: Relevant studies published were identified by searching the PubMed, Embase and Cochrane Library databases. Read More

Gen Thorac Cardiovasc Surg 2019 Feb 7. Epub 2019 Feb 7.

Department of Cardiovascular Surgery, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, 3290498, Japan.

Background: Although outcomes of acute type A aortic dissection (ATAAD) have improved, malperfusion remains associated with high morbidity and mortality rates, and its optimal therapeutic treatment is unknown. Emergency central repair has been performed as our first-line approach for malperfusion. Here, we analyzed outcomes of ATAAD with malperfusion and reassessed emergency central repair. Read More

BMC Surg 2019 Feb 4;19(1):17. Epub 2019 Feb 4.

Department of Hepatobiliary Surgery, the Second Affiliated Hospital, Nanchang University, No. 1, mingde road, Nanchang, Jiang xi, China.

Background: Hepatic portal vein gas (HPVG) is a rare acute abdomen, which is not an independent disease. Meanwhile, HPVG combined with appendicitis has been rarely reported. We found only a similar report by looking for literature, but no intestinal necrosis occurred. Read More

Am J Physiol Gastrointest Liver Physiol 2019 Feb 4. Epub 2019 Feb 4.

Clinical Sciences, North Carolina State University.

Intestinal ischemia is an abdominal emergency with a mortality rate >50%, leading to epithelial barrier loss and subsequent sepsis. Epithelial renewal and repair after injury depend on intestinal epithelial stem cells (ISC) that reside within the crypts of Lieberkühn. Two ISC populations critical to epithelial repair have been described: 1) Active ISC (aISC; highly proliferative; Lgr5+, Sox9+) and 2) reserve ISC (rISC; less proliferative; Hopx+). Read More

Clin Sci (Lond) 2019 Feb 8;133(3):449-464. Epub 2019 Feb 8.

Department of Physiology and Pathohysiology, School of Basic Medical Science, Shandong University, Jinan 250012, China

The intestinal ischemia/reperfusion (I/R) injury is a common clinical event related with high mortality in patients undergoing surgery or trauma. Estrogen exerts salutary effect on intestinal I/R injury, but the receptor type is not totally understood. We aimed to identify whether the G protein-coupled estrogen receptor (GPER) could protect the intestine against I/R injury and explored the mechanism. Read More

Adv Emerg Nurs J 2019 Jan/Mar;41(1):23-32

Department of Emergency Medicine, University of Texas Southwestern Medical Center, Dallas.

Acute aortic dissection is a life-threatening condition with the potential for serious complications such as myocardial infarction, heart failure, stroke, paraplegia, renal failure, mesenteric ischemia, and limb ischemia. Emergency department clinicians must be aware of the potential ischemic complications of aortic dissection and act quickly to prevent irreversible organ damage and death. This article highlights a case of a 49-year-old man who developed renal and lower extremity malperfusion secondary to Stanford Type A aortic dissection. Read More

J Surg Res 2019 Mar 16;235:410-423. Epub 2018 Nov 16.

Institute for Clinical and Experimental Surgery, Saarland University Medical Center, Homburg, Saar, Germany.

Background: Gastrointestinal blood flow may be compromised during and after vasopressor support. Endothelin expression may lead to microcirculatory dysfunction. The aim of this study was to analyze the effect of vasopressin and dobutamine after mesenteric ischemia on the gastrointestinal mucosal microcirculation, endothelin expression, and morphologic injury. Read More

Asian J Surg 2019 Jan 23. Epub 2019 Jan 23.

Ataturk University, Medical Faculty, Department of Pathology, Erzurum, Turkey.

Background: Although posttraumatic mesenteric artery ischemia is attributed to various etiologies, sacral parasympathetic network/mesenteric artery relations have not been studied so far. The primary objective of this study is to elucidate whether there is a relationship between Onuf's nucleus ischemia and mesenteric artery vasospasm following subarachnoid hemorrhage (SAH).

Methods: This study was conducted on 22 rabbits. Read More

Vasc Specialist Int 2018 Dec 31;34(4):83-87. Epub 2018 Dec 31.

Department of Surgery, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.

Purpose: Thrombosis of the portal vein, known as pylephlebitis, is a rare and fatal complication caused by intraperitoneal infections. The disease progression of superior mesenteric venous thrombosis (SMVT) is not severe. This study aimed to determine the clinical features, etiology, and prognosis of SMVT. Read More

CVIR Endovasc 2018 25;1(1):18. Epub 2018 Sep 25.

Department of Cardiovascular Surgery and Department of Cardiology, Yokohama Sakae Kyosai Hospital, 132, Katsuracho, Sakae-ku Yokohama-shi, Kanagawa 247-8581 Japan.

Background: Endovascular therapy (ET) for chronic mesenteric ischemia (CMI) is a effective treatment to relieve the symptoms, such as postprandial abdominal pain, food fear, and progressive weight loss. CMI is not known to be caused by rare anatomical variation of severe stenosis of the superior mesenteric artery (SMA), with replaced the common hepatic artery to the SMA. The treatment of such a rare anatomical variation using ET technique has not been discribed. Read More

Rozhl Chir 2018 ;97(11):487-492

Introduction: Due to the high success rate of endovascular procedures, open surgical treatment of visceral arteries has become rarer worldwide. Yet, open surgical techniques remain essential for cases of chronic mesenteric ischemia as well as in other clinical instances.

Methods: Drawing on their own experience and literary data, the authors summarize the indications to open surgical repair of the visceral arteries. Read More

Radiologe 2019 Feb;59(2):133-138

Klinische Abteilung für Kardiovaskuläre und Interventionelle Radiologie, Universitätsklinik für Radiologie und Nuklearmedizin, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.

Clinical Issue: Vascular abnormalities are a rare cause of an acute abdomen. They include arterial bleeding and ischemia, the latter being either in the arterial or venous system. The most common cause of an acute ischemic abdomen is acute mesenteric ischemia caused by a thromboembolic occlusion of the superior mesenteric artery, followed by thrombotic occlusion of the portal vein, the mesenteric vein as well as the hepatic veins and the suprahepatic part of the inferior vena cava. Read More

BMC Nephrol 2019 Jan 11;20(1):16. Epub 2019 Jan 11.

Department of Nephrology, Tongji Hospital, Tongji University School of Medicine, 389 XinCun Road, Shanghai, 200065, China.

Background: Recent researches indicate that the intestinal consequences of renal ischemia reperfusion (IR) would predispose to the translocation of gut-derived endotoxin. Here, we designed experiments to test the hypothesis that the gut-derived endotoxin has a potential role in mediating local inflammatory processes in the acutely injured kidney.

Methods: Rats were performed sham or renal IR surgery (60 min of bilateral renal ischemia, then 24 h of reperfusion) (n = 5). Read More

J Pathol 2019 Jan 11. Epub 2019 Jan 11.

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK.

Ischemia/reperfusion (I/R) injury is a severe inflammatory insult associated with numerous pathologies such as myocardial infarction, stroke and acute kidney injury. I/R injury is characterized by a rapid influx of activated neutrophils secreting toxic free radical species and degrading enzymes that can irreversibly damage the tissue, thus impairing organ functions. Significant efforts have been invested in identifying therapeutic targets to suppress neutrophil recruitment and activation post I/R injury. Read More

Mol Med Rep 2019 Mar 4;19(3):1840-1848. Epub 2019 Jan 4.

Department of General Surgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R. China.

The pathogenesis of intestinal ischemia/reperfusion (I/R) is associated with dysregulation of the intestinal immune system. The aryl hydrocarbon receptor (AhR), a receptor expressed in gamma‑delta (γδ) intraepithelial lymphocytes (IELs), is thought to regulate inflammation in the bowel. γδIELs are a key immunologic compartment with a capacity to modulate immune responses. Read More

Acta Cir Bras 2018 Dec;33(12):1095-1102

PhD, Associated Professor, Surgical Technique and Experimental Surgery, UNIFESP, Sao Paulo-SP, Brazil. Manuscript preparation, final approval.

Purpose: To investigate the gene expression related to inflammation on mice subjected to intestinal ischemia and reperfusion (I/R) and treated with ischemic preconditioning (IPC).

Methods: Thirty rats (EPM-Wistar), distributed in five groups of six animals each, were underwent anesthesia and laparotomy. The ischemia time was standardized in 60 minutes and the reperfusion time 120 minutes. Read More

Acta Cir Bras 2018 Dec;33(12):1061-1066

PhD, Full Professor, Division of Surgical Techniques and Experimental Surgery, Department of Surgery, UNIFESP, Sao Paulo-SP, Brazil. Conception and design of the study, critical revision, final approval.

Purpose: To investigate the role of atenolol in the gene expression of caspase 1 (Casp1) and Bcl2L1 on vascular endothelium of rat intestine after ischemia and reperfusion (IR).

Methods: Eighteen adult male Wistar rats were randomly divided into 3 groups (n=6): SG (Sham group): no clamping of the superior mesenteric artery; IRG: IR plus saline group: IRG+At: IR plus Atenolol group. Rats from IRG and IRG+At were subjected to 60 min of intestinal ischemia and 120 min of reperfusion. Read More

Vascular 2019 Jan 8:1708538118818625. Epub 2019 Jan 8.

2 GreeceDepartment of Vascular Surgery, Medical School, National and Kapodistrian University of Athens, "Attikon" University Hospital, Athens.

Objectives: Spontaneous isolated superior mesenteric artery dissection (SISMAD) is a rare disease with an incidence of 0.06%. The purpose of the meta-analysis was to identify the outcomes associated with the various treatment options in the management of asymptomatic and symptomatic patients with SISMAD. Read More

JGH Open 2018 Dec 10;2(6):327-328. Epub 2018 Oct 10.

Jonathan Edwards College Yale University New Haven Connecticut USA.

bacteremia is nearly always pathological and has been associated with colorectal cancer and endocarditis. Here, we present the first published case of bacteremia secondary to acute mesenteric ischemia. This case illustrates the typical presentation of acute mesenteric ischemia with an atypical consequence of bacteremia, as well as the diagnostic evaluations and management options. Read More

J Vasc Surg 2019 Jan 3. Epub 2019 Jan 3.

W. L. Gore & Associates, Inc, TAMBE Team, Flagstaff, Ariz.

Objective: This study reports the technical aspects and 30-day outcomes of the prospective, multicenter early feasibility study designed to evaluate the GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis (TAMBE; W. L. Gore & Associates, Flagstaff, Ariz). Read More

Surg Radiol Anat 2019 Jan 3. Epub 2019 Jan 3.

General, Digestive, and Endocrine Surgery, Nouvel Hôpital Civil, Université de Strasbourg, 1 Place de L'hôpital, 67100, Strasbourg, France.

Aberrant splenic artery originating from the superior mesenteric artery (SMA) is extremely rare and recognition of this anomaly is important in the pre-operative planning of complex surgery such as pancreatic surgery, liver transplantation and vascular surgery. We present the case of an 80-year-old female diagnosed as septic shock due to mesenteric ischemia and obstructive pyelonephritis. Her splenic artery was originating from the SMA and the anomaly was readily appreciated on the pre-operative CT images. Read More

Am Surg 2018 Dec;84(12):e558-e560

Spine Deform 2019 01;7(1):176-179

Department of Orthopedics, University Medical Center Utrecht, Heidelberglaan 100 3584 CX, Utrecht, the Netherlands.

Compression of the celiac artery by a tight arcuate ligament of the diaphragm is a rare syndrome that can arise after correction of severe kyphosis. Symptoms include abdominal pain and ileus and liver dysfunctions. These symptoms can be easily attributed to more common causes like the superior mesenteric artery syndrome, and a delay in the diagnosis of celiac artery obstruction may result in severe ischemic disease of the gastrointestinal tract. Read More

J Vasc Surg 2019 Jan 29;69(1):129-140. Epub 2018 Jun 29.

Division of Vascular Surgery & Endovascular Therapy, University of Florida, Gainesville, Fla.

Background: Acute mesenteric ischemia (AMI) is a challenging clinical problem associated with significant morbidity and mortality. Few contemporary reports focus specifically on patients undergoing open mesenteric bypass (OMB) or delineate outcome differences based on bypass configuration. This is notable, because there is a subset of patients who are poor candidates for endovascular intervention including those with flush mesenteric vessel occlusion, long segment occlusive disease, and a thrombosed mesenteric stent and/or bypass. Read More

J Endovasc Ther 2019 Feb 24;26(1):88-89. Epub 2018 Dec 24.

6 Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milan, Italy.

Gastrointest Endosc 2019 01;89(1):103-104

Department of Endoscopy, Ulm University, Center of Internal Medicine, Ulm, Germany.

G Chir 2018 Nov-Dec;39(6):391-394

Introduction: Pneumatosis intestinalis (PI) is described as the presence of air within bowel wall. PI aetiology is various: it can be associated with non-urgent or life-threatening conditions. Clinical management is based on physical examination, blood tests and radiology, in particular abdominal CT. Read More

Acta Biomed 2018 Dec 17;89(9-S):158-172. Epub 2018 Dec 17.

Department of Emergency and Trauma Surgery of University Hospital of Parma, Parma, Italy.

Background: Contrast enhanced Computed Tomography (CCT) is the most used imaging test to investigate acute abdominal clinical conditions, because of its high sensitivity and specificity. It is mandatory to make a correct and prompt diagnosis when life threatening abdominal diseases as mesenteric ischemia are suspected. Contrast medium administration was linked to acute renal failure, therefore radiologist often prefer to perform CCT without contrast in patients needing to undergo the exam with increased serum creatinine. Read More

Eur J Radiol Open 2019 7;6:9-15. Epub 2018 Dec 7.

Department of Radiology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.

Objectives: To determine the incidence of rare spontaneous isolated visceral artery dissection (SIVAD), characterize its pathogenesis, and suggest treatment strategies.

Materials And Methods: We reviewed abdominal contrast-enhanced computed-tomography (CE-CT) scans from January 2005 to December 2016 retrospectively in our institution, identified 47 SIVAD patients and classified them into a symptomatic (n = 22) or asymptomatic group (n = 25). Further, we classified the five types based on the CE-CT images. Read More

J Thorac Cardiovasc Surg 2019 Jan 27;157(1):88-98. Epub 2018 Jul 27.

Department of Surgery, The University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, Iowa.

Background: The general goals of endovascular management in chronic distal thoracic aortic dissection are optimizing the true lumen, maintaining branch patency, and promoting false lumen (FL) thrombosis. Distal seal can be challenging in chronic distal thoracic aortic dissection due to the well-established secondary fenestrations and fibrotic septum. We describe our approach of distal landing zone optimization (DLZO) to enable full-diameter contact of the distal endoprosthesis. Read More

J Endovasc Ther 2019 Feb 14;26(1):83-87. Epub 2018 Dec 14.

1 Department of Vascular Surgery, Zhongshan Hospital Fudan University, Shanghai, China.

Purpose: To describe endovascular treatment of mesenteric malperfusion in a multichannel aortic dissection (MCAD) with full true lumen (TL) collapse following thoracic endovascular aortic repair (TEVAR).

Case Report: A 54-year-old man presented with chronic mesenteric ischemia and a previous TEVAR for MCAD complicated by superior mesenteric artery (SMA) malperfusion. Computed tomography angiography (CTA) demonstrated a 3-channel aortic dissection with a "false-true-false" configuration. Read More

Magy Seb 2018 Dec;71(4):149-154

Általános, Ér- és Plasztikai Sebészeti Osztály, Markusovszky Egyetemi Oktatókórház 9700 Szombathely, Markusovszky Lajos u. 5.

Introduction: The incidence of acute mesenteric ischemia (AMI) appears to be increasing due to aging in the population with increasing prevalence of comorbidities. Despite the wide-scale availability of diagnostic technologies, the timely detection and correct treatment are not ensured. This is due to the fact that the required CT angiography is not immediately performed and that vascular surgical reconstruction can be performed within the short ischemic tolerance window of the bowels amounting 4-6 hours. Read More

Ann Surg Oncol 2019 Feb 11;26(2):652. Epub 2018 Dec 11.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler, Unit 1484, Houston, TX, USA.

Introduction: Patients with locally advanced pancreatic cancer (LAPC) represent a challenging group to treat, given the involvement of major vascular structures. In selected patients with favorable biology, temporary mesocaval shunt can facilitate the resection and allow for a safer procedure with enhanced exposure to the superior mesenteric vessels.

Methods: We present a video of a pancreaticoduodenectomy (PD) with temporary mesocaval shunt with left internal jugular (LIJ) vein conduit. Read More

Am J Gastroenterol 2019 Feb;114(2):348-351

APHP, Department of Gastroenterology, IBD and Intestinal Failure, Beaujon Hospital, 92110, Clichy, France.

Objectives: To identify treatments likely to prevent progression towards irreversible transmural intestinal necrosis (ITIN) in acute mesenteric ischemia (AMI).

Methods: Prospective observational cohort study from a French intestinal stroke center. Multivariate analysis using a time-dependent Cox regression model. Read More

BMC Pregnancy Childbirth 2018 Dec 11;18(1):487. Epub 2018 Dec 11.

Department of Obstetrics and Gynecology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.

Background: Mesenteric venous thrombosis (MVT) is an infrequent thrombotic event that can cause devastating intestinal hemorrhagic ischemia. The mortality rate among patients with acute MVT ranges from 20 to 50%. Occurrence of MVT in pregnancy is quite rare. Read More

J Vasc Surg 2018 Oct 24. Epub 2018 Oct 24.

Department of Endovascular and Vascular Surgery, Geisinger Medical Center, Danville, Pa.

Objective: Mesenteric angioplasty and stenting (MAS) has surpassed open revascularization as the treatment of choice for mesenteric ischemia. Despite the lower perioperative mortality associated with MAS, the need for reintervention is not infrequent. The purpose of this study was to review the outcomes of patients treated for mesenteric artery in-stent restenosis (MAISR). Read More

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Department of Paediatric Surgery, Royal Hospital for Sick Children, Edinburgh, UK. Electronic address:

Aim Of The Study: The aim of the study was to identify major gastrointestinal complications associated with direct jejunal feeding. We hypothesized that jejunal feeding may cause life-threatening surgical complications in a minority of patients.

Methods: All patients undergoing jejunal feeding between 1/2008 and 1/2018 at a pediatric surgical unit were identified retrospectively. Read More

J Vasc Interv Radiol 2019 Jan 7;30(1):43-48. Epub 2018 Dec 7.

Department of Vascular and Interventional Radiology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, China. Electronic address:

Purpose: To review preliminary efficacy and safety outcomes of mechanical thrombectomy using the Solitaire AB device combined with thromboaspiration for treatment of acute embolic occlusion of the superior mesenteric artery (SMA).

Materials And Methods: Between October 2015 and October 2017, 9 patients (average age, 77 y; range, 62-84 y) presenting with acute mesenteric ischemia attributable to embolic occlusion at the stem of the SMA were retrospectively evaluated for mechanical thrombectomy using the Solitaire AB device combined with manual thromboaspiration. Adjunctive stent implantation was performed to correct pre-existing atherosclerotic stenosis or as a rapid recanalization solution after unsuccessful thrombectomy. Read More

J Surg Res 2019 Feb 23;234:294-302. Epub 2018 Oct 23.

Department of Surgery, Section of Pediatric Surgery, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana; Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

Background: Necrotizing enterocolitis (NEC) in premature infants is often a devastating surgical condition with poor outcomes. GYY4137 is a long-acting donor of hydrogen sulfide, a gasotransmitter that is protective against intestinal injury in experimental NEC, likely through protection against injury secondary to ischemia. We hypothesized that administration of GYY4137 would improve mesenteric perfusion, reduce intestinal injury, and reduce inflammatory responses in experimental NEC and ischemia-reperfusion injury, and that these benefits would be mediated through endothelial nitric oxide synthase-dependent pathways. Read More

Biol Pharm Bull 2018 ;41(12):1874-1878

Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University.

The aims of this study were to determine the effects of gamma-aminobutyric acid (GABA) on immunoglobulin A (IgA) secretion from Peyer's patch (PP) cells; to assess rat alpha-defensin-5 (RD-5) expression in the rat small intestine; and to determine the effect of GABA on intestinal ischemia reperfusion (I/R) injury-induced intestinal innate immunity. We found that GABA caused an increase in IgA secretion in the presence and absence of lipopolysaccharide (LPS). Moreover, GABA also significantly increased the mRNA levels of RD-5 and superoxide dismutase (Sod) 1, 3. Read More

Am J Emerg Med 2019 Feb 7;37(2):378.e1-378.e6. Epub 2018 Nov 7.

Department of Emergency Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Acute mesenteric venous thrombosis (MVT) is an uncommon cause of intestinal ischemia and is associated with high morbidity and mortality. Patients with acute MVT often present with gastrointestinal (GI) bleeding and other unspecific findings making the diagnosis challenging. This condition requires emergent treatment. Read More

J Surg Res 2019 Jan 26;233:8-19. Epub 2018 Jul 26.

Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Background: Transferred emergency general surgery (EGS) patients have increased morbidity, mortality, and costs, yet little is known about the characteristics of such transfers. Increasing specialization and a decreasing general surgery workforce have led to concerns about access to care, which may lead to increased transfers. We sought to evaluate the reasons for and timing of transfers for EGS diagnoses. Read More