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Surg Laparosc Endosc Percutan Tech 2018 Dec 11. Epub 2018 Dec 11.

Departments of General Surgery.

Although high-ligated pedicle of the inferior mesenteric artery is usually kept in the resected specimens, the value of preserving high-ligated pedicle of the inferior mesenteric vein within the resected specimens of the sphincter saving rectal resections for cancer is not well defined. In the current study, patients undergoing open, laparoscopic, and robotic sphincter saving rectal resection for cancer were prospectively included. Lymph node invasion and presence of lymph nodes along the IMV pedicles were analyzed. Read More

Magy Seb 2018 Dec;71(4):149-154

Általános, Ér- és Plasztikai Sebészeti Osztály, Markusovszky Egyetemi Oktatókórház 9700 Szombathely, Markusovszky Lajos u. 5.

Introduction: The incidence of acute mesenteric ischemia (AMI) appears to be increasing due to aging in the population with increasing prevalence of comorbidities. Despite the wide-scale availability of diagnostic technologies, the timely detection and correct treatment are not ensured. This is due to the fact that the required CT angiography is not immediately performed and that vascular surgical reconstruction can be performed within the short ischemic tolerance window of the bowels amounting 4-6 hours. Read More

Arq Bras Cir Dig 2018 Dec 6;31(4):e1403. Epub 2018 Dec 6.

University Center UNIFACISA), João Pessoa, PB.

Introduction: The celiac trunk (CT) is one of the abdominal portion branches of the aortic artery and, together with the superior mesenteric and inferior mesenteric arteries, participates in the abdominal viscera vascularization through a series of anastomoses. Absence of CT or variation in the number of terminal branches implies in varied abdominal arteries origins, which may have implication in surgical approaches.

Objective: To analyze the anatomical variations of the celiac trunk and possible associated surgical clinical implications. Read More

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler, Unit 1484, Houston, TX, USA.

Introduction: Patients with locally advanced pancreatic cancer (LAPC) represent a challenging group to treat, given the involvement of major vascular structures. In selected patients with favorable biology, temporary mesocaval shunt can facilitate the resection and allow for a safer procedure with enhanced exposure to the superior mesenteric vessels.

Methods: We present a video of a pancreaticoduodenectomy (PD) with temporary mesocaval shunt with left internal jugular (LIJ) vein conduit. Read More

J Immunol Res 2018 13;2018:1827901. Epub 2018 Nov 13.

Life Science School, Liaoning University, Shenyang 110036, China.

Background: Previously, we have reported that IL-33 functioned as a protective modulator in dextran sulfate sodium- (DSS-) induced chronic colitis by suppressing Th17 cell response in colon lamina propria and IL-33 induced both regulatory B cells (Bregs) and regulatory T cells (Tregs) in mesenteric lymph nodes (MLNs) of mice with DSS-induced acute colitis. Moreover, we speculated that IL-33 would promote the Treg or Breg responses leading to the attenuation of DSS-induced chronic colitis. So, we investigated the role of IL-33 on Bregs and Tregs in the MLN of DSS-induced chronic colitis mice. Read More

Front Oncol 2018 27;8:553. Epub 2018 Nov 27.

College of Engineering, Mathematics and Physical Sciences, Department of Physics and Astronomy, University of Exeter, Exeter, United Kingdom.

Acute Lymphoblastic Leukemia (ALL) remains the most frequent cause of cancer-related mortality in children and novel therapies are needed for the treatment of relapsed/refractory childhood ALL. One approach is the targeting of ALL blasts with the immunotoxin CAT-8015. Although CAT-8015 has potent anti-leukemia activity, with a 32% objective response rate in a phase 1 study of childhood ALL, haemolytic-uremic syndrome (HUS) and vascular leak syndrome (VLS), major dose-limiting toxicities, have limited the use of this therapeutic approach in children. Read More

Am J Gastroenterol 2018 Dec 11. Epub 2018 Dec 11.

APHP, Department of Gastroenterology, IBD and Intestinal Failure, Beaujon Hospital, 92110, Clichy, France.

Objectives: To identify treatments likely to prevent progression towards irreversible transmural intestinal necrosis (ITIN) in acute mesenteric ischemia (AMI).

Methods: Prospective observational cohort study from a French intestinal stroke center. Multivariate analysis using a time-dependent Cox regression model. Read More

BMC Pregnancy Childbirth 2018 Dec 11;18(1):487. Epub 2018 Dec 11.

Department of Obstetrics and Gynecology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.

Background: Mesenteric venous thrombosis (MVT) is an infrequent thrombotic event that can cause devastating intestinal hemorrhagic ischemia. The mortality rate among patients with acute MVT ranges from 20 to 50%. Occurrence of MVT in pregnancy is quite rare. Read More

J Cardiol Cases 2013 Nov 26;8(5):145-147. Epub 2013 Sep 26.

Kokura Memorial Hospital, Kokura, Japan.

A 73-year-old man underwent sirolimus-eluting stent (SES) implantation for chest pain on exertion with left anterior descending coronary artery (LAD) and left circumflex coronary artery (LCX). The patient died due to non-obstructive mesenteric ischemia after 57 months of SES implantation. An autopsy demonstrated that the lesions of stented site at LAD and LCX were histopathologicaly similar images. Read More

J Cardiol Cases 2010 Oct 6;2(2):e78-e82. Epub 2010 May 6.

Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center 5-3-1 Chikami, Kumamoto-city, 861-4193, Japan.

A 70-year-old man complained of abdominal angina after endovascular aneurysm repair (EVAR). He had a history of successful treatment of abdominal aortic aneurysm with Zenith endovascular graft 12 months prior to the index abdominal symptoms. The endovascular graft had been placed with special attention for keeping blood flow of major abdominal branches to the intestine. Read More

Zentralbl Chir 2018 Dec 11. Epub 2018 Dec 11.

Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Jena, Deutschland.

True visceral artery aneurysms (VAA) and visceral artery pseudoaneurysms (VAPA) are located in the celiac trunk, the superior mesenteric artery and inferior mesenteric artery. In addition to surgical treatment, endovascular embolisation therapy of visceral aneurysms and pseudoaneurysms is an alternative interventional method that has developed precipitously over the last two decades and is considered a first-choice method in many centres. The procedure is characterised by a high technical success rate with a low complication rate. Read More

Afr J Emerg Med 2018 Dec 2;8(4):164-166. Epub 2018 Oct 2.

Department of Emergency Medicine, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA.

Introduction: The term refers to a clinical syndrome of sudden onset, severe abdominal pain. The differential diagnosis for this presentation is broad, but most cases require emergent medical or surgical management. Especially in cases of ischaemic bowel, time to diagnosis can mean the difference between survival and death. Read More

Nihon Shokakibyo Gakkai Zasshi 2018 ;115(12):1063-1068

Department of Medical Oncology, Shizuoka General Hospital.

A 65-year-old woman who had been diagnosed with dermatomyositis presented to the hospital with a small bowel mass. She had tested positive for fecal occult blood test and anemia at a medical checkup;therefore, computerized tomography (CT) was performed at the previous hospital and it had revealed thickening of the intestinal wall. Abdominal contrast-enhanced CT, single-balloon assisted enteroscopy, and biopsy led to a diagnosis of poorly differentiated jejunal adenocarcinoma. Read More

J Immunol 2018 Dec 7. Epub 2018 Dec 7.

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229;

Regulation of the intestinal mucus layer by goblet cells is important for preventing inflammation and controlling infection. IL-33, a cytokine upregulated in inflammatory bowel disease and helminth infection, induces intestinal goblet cells, but the mechanism remains unclear. Enteroids are three-dimensional structures of primary small intestinal epithelial cells that contain all differentiated intestinal epithelial cell types. Read More

J Vasc Surg 2018 Oct 24. Epub 2018 Oct 24.

Department of Endovascular and Vascular Surgery, Geisinger Medical Center, Danville, Pa.

Objective: Mesenteric angioplasty and stenting (MAS) has surpassed open revascularization as the treatment of choice for mesenteric ischemia. Despite the lower perioperative mortality associated with MAS, the need for reintervention is not infrequent. The purpose of this study was to review the outcomes of patients treated for mesenteric artery in-stent restenosis (MAISR). Read More

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Department of Paediatric Surgery, Royal Hospital for Sick Children, Edinburgh, UK. Electronic address:

Aim Of The Study: The aim of the study was to identify major gastrointestinal complications associated with direct jejunal feeding. We hypothesized that jejunal feeding may cause life-threatening surgical complications in a minority of patients.

Methods: All patients undergoing jejunal feeding between 1/2008 and 1/2018 at a pediatric surgical unit were identified retrospectively. Read More

J Vasc Interv Radiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Vascular and Interventional Radiology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, China. Electronic address:

Purpose: To review preliminary efficacy and safety outcomes of mechanical thrombectomy using the Solitaire AB device combined with thromboaspiration for treatment of acute embolic occlusion of the superior mesenteric artery (SMA).

Materials And Methods: Between October 2015 and October 2017, 9 patients (average age, 77 y; range, 62-84 y) presenting with acute mesenteric ischemia attributable to embolic occlusion at the stem of the SMA were retrospectively evaluated for mechanical thrombectomy using the Solitaire AB device combined with manual thromboaspiration. Adjunctive stent implantation was performed to correct pre-existing atherosclerotic stenosis or as a rapid recanalization solution after unsuccessful thrombectomy. Read More

J Vasc Interv Radiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiology, Kyungpook National University School of Medicine, Daegu, Korea.

Purpose: To retrospectively investigate the impact of hyperbilirubinemia on future liver remnant (FLR) volume after percutaneous transhepatic portal vein embolization (PVE) and incidence of post-hepatectomy liver failure in primary biliary malignancy.

Materials And Methods: Eighty-seven patients (62 men, overall mean age 66.9 y) who underwent PVE, using Gelfoam and coils before major hepatectomy between January 2004 and June 2016, were included in this study and divided into a hyperbilirubinemia (serum total bilirubin level at PVE 5. Read More

J Surg Res 2019 Feb 23;234:294-302. Epub 2018 Oct 23.

Department of Surgery, Section of Pediatric Surgery, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana; Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

Background: Necrotizing enterocolitis (NEC) in premature infants is often a devastating surgical condition with poor outcomes. GYY4137 is a long-acting donor of hydrogen sulfide, a gasotransmitter that is protective against intestinal injury in experimental NEC, likely through protection against injury secondary to ischemia. We hypothesized that administration of GYY4137 would improve mesenteric perfusion, reduce intestinal injury, and reduce inflammatory responses in experimental NEC and ischemia-reperfusion injury, and that these benefits would be mediated through endothelial nitric oxide synthase-dependent pathways. Read More

Free Radic Res 2018 Dec 10:1-171. Epub 2018 Dec 10.

b Department of Emergency Medical Services , Eulji University , Seongnam , Republic of Korea.

Oxidative stress is associated with many cardiovascular diseases, such as hypertension and arteriosclerosis. Oxidative stress reportedly activates the L-type voltage-gated calcium channel (VDCC) and elevates [Ca] in many cells. However, how oxidative stress activates VDCC under clinical setting and the consequence for arteries are unclear. Read More

Mol Nutr Food Res 2018 Dec 6:e1800985. Epub 2018 Dec 6.

R. Pei, D. A. Martin, J. C. Valdez, J. Liu, B. W. Bolling, University of Wisconsin-Madison, Department of Food Science,, 1605 Linden Dr., Madison, WI, 53706, USA.

Scope: Increased fruit consumption is associated with reduced risk of colitis. We investigated whether the anti-colitic effects of the polyphenol-rich aronia berry (Aronia mitschurinii 'Viking') were mediated through Th17 and Treg.

Methods And Results: Colitis was induced in recombinase activating gene-1 deficient mice injected with syngeneic CD4 CD62L naïve T cells. Read More

Ann Med Surg (Lond) 2018 Dec 13;36:231-234. Epub 2018 Nov 13.

Department of Surgery, University Hospital Hairmyres, NHS Lanarkshire, East Kilbride, G75 8RG, Scotland, UK.

Introduction: Unexplained lactic acidosis (LA) in a critically ill patient often prompts investigations to rule out any reversible intra-abdominal cause. Equivocal results can lead to an emergency laparotomy (EL) with subsequent high morbidity and mortality rates. Our objective was to determine the clinical impact of urgent diagnostic laparoscopy (UDL) in such patients. Read More

Front Integr Neurosci 2018 21;12:57. Epub 2018 Nov 21.

The John B. Pierce Laboratory, Yale University, New Haven, CT, United States.

In most species, including humans, food preference is primarily controlled by nutrient value. In particular, glucose-containing sugars exert exquisitely strong effects on food choice via gut-generated signals. However, the identity of the visceral signals underlying glucose's rewarding effects remains uncertain. Read More

Vet Res 2018 Dec 5;49(1):119. Epub 2018 Dec 5.

Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.

Trichinellosis is one of the most serious foodborne parasitic zoonosis with worldwide distribution, and it is necessary to develop a vaccine to interrupt transmission from animals to humans. Trichinella spiralis adult-specific DNase II-1 (TsDNase II) were identified by immunoproteomics in surface or excretory/secretory proteins of adult worms (AW) and intestinal infective larvae (IIL). The aim of this study was to investigate the systemic, mucosal responses and immune protection elicited by oral vaccination with TsDNase II DNA vaccine delivered by attenuated Salmonella typhimurium strain⊿cyaSL1344. Read More

BMC Complement Altern Med 2018 Dec 5;18(1):322. Epub 2018 Dec 5.

Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, CA, 94710, USA.

Background: Human infection by pathogenic Salmonella bacteria can be acquired by consuming of undercooked meat products and eggs. Antimicrobial resistance against antibiotics used in medicine is also a major concern. To help overcome these harmful effects on microbial food safety and human health, we are developing novel antimicrobial food-compatible formulations, one of which is described in the present study. Read More

J Asian Nat Prod Res 2018 Dec 3:1-14. Epub 2018 Dec 3.

a School of Pharmacy, Xi'an Jiaotong University , Xi'an 710061 , China.

A series of novel biphenyl-furocoumarin derivatives were synthesized based on the nuclear structure of imperatorin and identified by IR, H NMR, C NMR and MS, and evaluated for their ability to relax vessel on isolated rat mesenteric artery, basilar artery and renal artery, respectively. The majority of compounds demonstrated potent vasodilatation, and compound 8e expressed the highest activity (EC = 0.56 μM) in MA. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1291-1295

Department of Gastrointestinal Surgery, Provincial Clinical College, Fujian Medical University, Fuzhou 350001, China.

Objective: To investigate the safety of the controllable ileostomy with pipe in view of histology.

Methods: Twenty-eight Beagle dogs undergoing controllable ileostomy with pipe were studied. The special fistula tube with balloon was placed into the hole locating at the cecal root opposing the mesenteric side, and fixed by double knot compression method. Read More

Eur Radiol 2018 Nov 30. Epub 2018 Nov 30.

Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK.

Methods: We applied multiparametric MRI to assess changes in liver composition, perfusion and blood flow in 17 patients before direct-acting antiviral (DAA) therapy and after treatment completion (within 12 weeks of last DAA tablet swallowed).

Results: We observed changes in hepatic composition indicated by a reduction in both liver longitudinal relaxation time (T1, 35 ± 4 ms), transverse relaxation time (T2, 2.5 ± 0. Read More

Acta Pharm Sin B 2018 Oct 26;8(6):909-918. Epub 2018 Jul 26.

Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150086, China.

Our previous studies found that mitochondrial uncouplers CCCP and niclosamide inhibited artery constriction and the mechanism involved AMPK activation in vascular smooth muscle cells. BAM15 is a novel type of mitochondrial uncoupler. The aim of the present study is to identify the vasoactivity of BAM15 and characterize the BAM15-induced AMPK activation in vascular smooth muscle cells (A10 cells). Read More

Biol Pharm Bull 2018 ;41(12):1874-1878

Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University.

The aims of this study were to determine the effects of gamma-aminobutyric acid (GABA) on immunoglobulin A (IgA) secretion from Peyer's patch (PP) cells; to assess rat alpha-defensin-5 (RD-5) expression in the rat small intestine; and to determine the effect of GABA on intestinal ischemia reperfusion (I/R) injury-induced intestinal innate immunity. We found that GABA caused an increase in IgA secretion in the presence and absence of lipopolysaccharide (LPS). Moreover, GABA also significantly increased the mRNA levels of RD-5 and superoxide dismutase (Sod) 1, 3. Read More

Crit Care Nurse 2018 Dec;38(6):e5-e12

Christine Peyton is a clinical nurse specialist at the Heart Institute at Children's Hospital Colorado, Aurora, Colorado.

Protein-losing enteropathy and plastic bronchitis remain challenging to treat despite recent treatment advances. Protein-losing enteropathy and plastic bronchitis have been diagnosed in patients with cardiomyopathy, constrictive pericarditis, and congestive heart failure. This article focuses on patients with protein-losing enteropathy or plastic bronchitis following the Fontan procedure. Read More

Pediatr Neonatol 2018 Sep 4. Epub 2018 Sep 4.

Necmettin Erbakan University, Meram Medical Faculty, Department of Pediatrics, Division of Neonatology, Meram, Konya, Turkey.

Am J Emerg Med 2018 Nov 7. Epub 2018 Nov 7.

Department of Emergency Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Acute mesenteric venous thrombosis (MVT) is an uncommon cause of intestinal ischemia and is associated with high morbidity and mortality. Patients with acute MVT often present with gastrointestinal (GI) bleeding and other unspecific findings making the diagnosis challenging. This condition requires emergent treatment. Read More

Cell Stem Cell 2018 Nov 21. Epub 2018 Nov 21.

Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. Electronic address:

Human intestinal transplantation often results in long-term mixed chimerism of donor and recipient blood in transplant patients. We followed the phenotypes of chimeric peripheral blood cells in 21 patients receiving intestinal allografts over 5 years. Donor lymphocyte phenotypes suggested a contribution of hematopoietic stem and progenitor cells (HSPCs) from the graft. Read More

Ann Vasc Surg 2018 Nov 28. Epub 2018 Nov 28.

Vascular and Endovascular Surgery Unit, Deprtment of Surgery "P Stefanini", Policlinico "Umberto I", "Sapienza" University of Rome.

Objectives: Aim of this work is describing incidence and fate of type 2 endoleaks (T2EL) in a multi-centric cohort of patients treated by EVAR with Ovation device (Endologix), and compering them with a group treated by Excluder (W.L. Gore & Associates). Read More

J Mol Cell Cardiol 2018 Nov 28. Epub 2018 Nov 28.

Division of Geriatrics, Department of Internal Medicine, University of Utah School of Medicine, University of Utah, Salt Lake City, UT, USA; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA; Department of Biochemistry, University of Utah, Salt Lake City, UT, USA; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA. Electronic address:

Age-related vascular dysfunction in large elastic and resistance arteries is associated with reductions in microvascular perfusion and elevations in blood pressure. Recent evidence indicates that telomere uncapping-induced senescence in vascular cells may be an important source of oxidative stress and vascular dysfunction in aging, but the causal relationship between these processes has yet to be elucidated. To test this important unexplored hypothesis, we measured arterial senescence signaling and oxidative stress, carotid and mesenteric artery endothelium-dependent vasodilatory capacity, markers of mesenteric microvascular perfusion and endothelial glycocalyx deterioration, and blood pressure in a novel mouse model of Cre-inducible whole body Trf2 deletion and telomere uncapping. Read More

J Surg Res 2019 Jan 26;233:8-19. Epub 2018 Jul 26.

Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Background: Transferred emergency general surgery (EGS) patients have increased morbidity, mortality, and costs, yet little is known about the characteristics of such transfers. Increasing specialization and a decreasing general surgery workforce have led to concerns about access to care, which may lead to increased transfers. We sought to evaluate the reasons for and timing of transfers for EGS diagnoses. Read More

J Surg Res 2019 Jan 31;233:231-239. Epub 2018 Aug 31.

Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Background: Early identification of patients with acute mesenteric ischemia (AMI) involving the large bowel may play a decisive role in improving the prognosis of AMI. This study aims to compare the outcomes between patients with isolated AMI and AMI patients with colon involvement (CI) and to identify the predictors of worse outcomes. The different surgical modalities for AMI patients with CI were also evaluated. Read More

HPB (Oxford) 2018 Nov 27. Epub 2018 Nov 27.

Department of Surgery, University of Pittsburgh Medical Center, 5150 Center Ave, Pittsburgh, PA 15232, USA; Department of Surgery, West Virginia University, PO Box 9238 HSCS, Morgantown, WV 26506, USA. Electronic address:

Background: Achieving margin negative resection is a significant determinant of outcome in pancreatic adenocarcinoma (PDA). However, because of the fibrotic nature of PDA, it can be difficult to discriminate fibrosis from active disease intra-operatively. We sought to determine if post-hoc video review of robotic pancreatico-duodenectomy (RPD) could predict the portal/superior mesenteric vein (PV/SMV) margin status on final pathology. Read More

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):507-513

Department of Emergency Medicine, Adnan Menderes University Faculty of Medicine, Aydın-Turkey.

Background: The objective of the current study was to investigate the value of the ischemic biomarkers endothelial cell-specific molecule-1 (endocan) and signal peptide-CUB-EGF domain-containing protein-1 (SCUBE-1) in the diagnosis and assessment of earlystage and irreversible damage in acute mesenteric ischemia.

Methods: An experimental mesenteric ischemia reperfusion model was designed using 54 rats. Nine groups were created: Three sham groups [Groups I (30th minute), IV (2nd hour), and VII (6th hour)], in which only blood and tissue specimens were sampled; 3 ischemia groups [Groups II (30th minute), V (2nd hour), and VIII (6th hour)], in which blood and tissue specimens were sampled after ligation of the superior mesenteric artery (SMA); and 3 reperfusion groups [Groups III (30th minute), VI (2nd hour), and IX (6th hour)], in which blood and tissue specimens were sampled after declamping the SMA and reperfusion for 1 hour. Read More

Clin Physiol Funct Imaging 2018 Dec 4. Epub 2018 Dec 4.

Kyorin University Hospital, Tokyo, Japan.

Hemodynamics is subject to change after eating meals, which may be related to various postprandial physical statuses such as hypotension or daytime sleepiness. Previous studies have shown that blood flow in the superior mesenteric artery (SMA) increases after meals, but conflicting results have been reported regarding blood flow in the common carotid artery (CCA). In those studies, the fasting interval before the meal was not taken into account. Read More

Cardiovasc Intervent Radiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Purpose: To evaluate the incidence of type II endoleak (EL-II) and aneurysm enlargement after endovascular aneurysm repair (EVAR) using the Endurant stent graft in patients with abdominal aortic aneurysm (AAA) with occluded inferior mesenteric artery (IMA).

Materials And Methods: Between 2012 and 2017, 103 patients who underwent EVAR using the Endurant stent graft for AAA with occluded IMA (50 patients with prophylactic embolized IMA and 53 with spontaneous occluded IMA) were retrospectively reviewed. The incidence of EL-II and aneurysm enlargement was evaluated. Read More

Nutr Res Pract 2018 Dec 13;12(6):469-478. Epub 2018 Sep 13.

Department of Food and Nutrition, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 61452, Korea.

Background/objectives: Mulberry leaf (ML) has been shown to have an inhibitory effect on α-glucosidase, and suppresses postprandial hyperglycemia, which may be related to its deoxynojirimycin (DNJ) content. This study was conducted to investigate the hypoglycemic and dyslipidemic effects of rice coated with ML rich in DNJ in a type 2 diabetes mouse model.

Materials/methods: The mice were divided into four groups (n = 8 each): non-diabetic normal control (NC); diabetic control (DM-C), fed with 10% polished rice powder (DM-R); and fed with 10% polished rice powder coated with DNJ-rich ML (DM-DNJR). Read More

Pharmacol Rep 2018 Sep 28;71(1):105-111. Epub 2018 Sep 28.

Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Łódź, Poland; Department of General and Colorectal Surgery, Faculty of Military Medicine, Medical University of Lodz, Łódź, Poland. Electronic address:

Crohn's disease (CD) is a chronic, immune system-mediated inflammatory disease affecting gastrointestinal (GI) tract. The pathogenesis of the intestinal lesions is not entirely explained and understood: excessive activation of the immune system may come as a result of the interaction of environmental, genetic and infectious factors and the mediation of abnormal intestinal flora. The main objective of the current study is to further identify the role of adipose tissue in the pathogenesis of CD. Read More

ACS Chem Neurosci 2018 Dec 4. Epub 2018 Dec 4.

Green tea polyphenol epigallocatechin gallate (EGCG), promotes vasodilation and reduces blood pressure, mechanisms of which are not fully resolved. Recent reports suggested that EGCG can activate heterologously expressed mouse and zebrafish TRPA1 channels. Activation of TRPA1 in sensory neurons triggers the release of calcitonin gene-related peptide (CGRP), a potent vasodilator. Read More

World J Clin Cases 2018 Nov;6(14):847-853

Department of Pediatric Surgery, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China.

Heterotopic pancreas (HP) is a congenital anomaly defined as pancreatic tissue that has no contact with the orthotopic pancreas and its own duct system and vascular supply. The most common locations of HP are the upper gastrointestinal tract, specifically, the stomach, duodenum, and proximal jejunum. Involvement of the mesentery is rare. Read More

World J Gastrointest Surg 2018 Nov;10(8):90-94

Department of Pathology, Inonu University Faculty of Medicine, Malatya 244280, Turkey.

Intra-abdominal aggressive fibromatosis is a locally aggressive tumor mostly originating from the mesentery or retroperitoneal space, infiltrating adjacent tissues, and very rarely metastasizing to distant organs. There are only two case reports in the English language literature where intra-abdominal aggressive fibromatosis originated from the intestinal wall. In this study, we aimed to report a case of aggressive fibromatosis originating from the muscularis propria layer of the duodenum and invading pancreas. Read More

Am J Surg 2018 Nov 27. Epub 2018 Nov 27.

Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland. Electronic address:

Background: The aim of this study was to assess outcomes of octogenarians undergoing emergency abdominal surgery (EAS).

Methods: Octogenarians undergoing EAS 12/2011-12/2016 were retrospectively analysed. The outcomes were assessed by univariable and multivariable regression analysis. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13446

Department of General and Gastroenterological Surgery, Osaka Medical College, Daigaku-machi, Takatsuki.

Rationale: Liposarcoma (LPS) is a rare malignant soft-tissue tumor. Management of LPS is relatively difficult, because there are no characteristic symptoms, or biomarkers, nor any established effective treatment. Hence, the report of the accumulation of each LPS case is necessary. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13425

Department of Critical Care Medicine, Nantong Third People's Hospital, Nantong University.

Rationale: Extensive thrombosis in the portal venous system caused by hypereosinophilic syndrome (HES) is rare, and there is no consensus on anticoagulant and thrombolytic treatments for arteriovenous thrombosis caused by HES.

Patient Concerns: The clinical data of a patient with extensive thrombosis in his portal venous system (superior mesenteric, splenic, hepatic, and portal veins), renal artery thrombosis, and mesenteric thrombosis caused by HES with secondary gastrointestinal bleeding and intestinal necrosis were retrospectively analyzed. Before admission, his eosinophil count increased to 7. Read More