4,888 results match your criteria Mesenteric Artery Ischemia


Ischemic Colitis in Buerger's Disease: Case Presentation and Review.

Cureus 2020 May 26;12(5):e8303. Epub 2020 May 26.

Clinical Gastroenterology & Internal Medicine, Merit Health Rankin & William Carey University College of Osteopathic Medicine, Brandon, USA.

Buerger's disease is a type of vasculitis that predominantly affects small to medium arteries and the veins of the upper and lower extremities. Intestinal vessels are rarely involved. This is a case report of a 38-year-old male, smoker, with known Buerger's disease who was found to have ischemic colitis of the sigmoid colon on biopsy and inferior mesenteric artery occlusion on computed tomography (CT) angiography. Read More

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http://dx.doi.org/10.7759/cureus.8303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317139PMC

[Clinical implications of chronic mesenteric ischemia in elderly and senile patients].

Ter Arkh 2020 Apr 27;92(2):74-80. Epub 2020 Apr 27.

Chelyabinsk Regional Clinical Hospital.

Aim: To evaluate the sensitivity and specificity of the clinical criteria for the diagnosis of chronic mesenteric ischemia in elderly and senile patients with mesenteric atherosclerosis.

Materials And Methods: The study included 142 patients (82 men and 60 women). The median age of patients is 66. Read More

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http://dx.doi.org/10.26442/00403660.2020.02.000522DOI Listing

Amelioration of Coagulation Disorders and Inflammation by Hydrogen-Rich Solution Reduces Intestinal Ischemia/Reperfusion Injury in Rats through NF-B/NLRP3 Pathway.

Mediators Inflamm 2020 10;2020:4359305. Epub 2020 Jun 10.

Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Intestinal ischemia/reperfusion (I/R) injury often causes inflammatory responses and coagulation disorders, which is further promoting the deterioration of the disease. Hydrogen has anti-inflammatory, antioxidative, and antiapoptotic properties against various diseases. However, the effect of hydrogen on coagulation dysfunction after intestinal I/R and the underlying mechanism remains unclear. Read More

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http://dx.doi.org/10.1155/2020/4359305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303760PMC

Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats.

Eur J Pharmacol 2020 Jun 20:173265. Epub 2020 Jun 20.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran; Brain and Spinal Injury Repair Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Acute mesenteric ischemia (AMI) is caused by an abrupt cessation of blood flow to the small intestine. Reperfusion is the return of blood flow to the ischemic bowel. Intestinal ischemia/reperfusion (I/R) leads to the formation of reactive oxygen species, local inflammatory response, and may lead to the patient's death. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173265DOI Listing

Propofol improves intestinal ischemia-reperfusion injury in rats through NF-κB pathway.

Eur Rev Med Pharmacol Sci 2020 Jun;24(11):6463-6469

Department of Anesthesiology, Jinan City People's Hospital, Jinan, China.

Objective: The aim of this study was to investigate the effects of propofol on intestinal ischemia-reperfusion injury in rats through the nuclear factor-kappa B (NF-κB) pathway.

Materials And Methods: A total of 24 Sprague-Dawley rats were selected and randomly divided into three groups, including sham operation group, ischemia group and propofol group. Rats in sham operation group were only treated with isolation of superior mesenteric artery, which was clipped for 1 h and reperfused for 2 h in ischemia group. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21545DOI Listing

Ionizing radiation induces BH deficiency by downregulating GTP-cyclohydrolase 1, a novel target for preventing and treating radiation enteritis.

Biochem Pharmacol 2020 Jun 17:114102. Epub 2020 Jun 17.

Department of Radiotherapy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China. Electronic address:

Radiation enteritis (RE) is a common side effect after radiotherapy for abdominal cancer. RE pathogenesis is complicated, with no drugs available for prevention or treatments. Intestinal ischemia is a key factor in the occurrence and development of enteritis. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114102DOI Listing

Using the Outback Catheter to Overcome Aortic Re-entry Issues in Retrograde Open Mesenteric Stenting.

Ann Vasc Surg 2020 Jun 16. Epub 2020 Jun 16.

Department of Vascular and Thoracic Surgery, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Université de Paris, France; SURVI (Structure d'URgences Vasculaires Intestinales), Intestinal Stroke Center, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Université de Paris, France; Department of Vascular Surgery, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Université de Paris, France.

Purpose: To describe the use of the Outback catheter to overcome aortic re-entry issues in acute mesenteric ischemia (AMI) treated by retrograde open mesenteric stenting (ROMS).

Technique: The technique is demonstrated in two female patients presenting with late AMI related to flush occlusion of the SMA. In such cases of thrombotic AMI with clear preoperative evidence of intestinal necrosis, ROMS is the first-line revascularization technique in our intestinal stroke center. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.06.021DOI Listing

Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion.

World J Hepatol 2020 May;12(5):184-206

Departments of Pharmacology and Pathology, School of Medicine, University of Zagreb, Zagreb 10000, Croatia.

Background: The Pringle maneuver [portal triad obstruction(PTO)] provides huge disturbances during ischemia and even more thereafter in reperfusion. Contrarily, a possible solution may be stable gastric pentadecapeptide BPC 157, with already documented beneficial effects in ischemia/reperfusion conditions. Recently, BPC 157, as a cytoprotective agent, successfully resolved vessel occlusions in rats (ischemic colitis; deep vein thrombosis, superior anterior pancreaticoduodenal vein; bile duct cirrhosis) through rapid collateral vessel recruitment to circumvent vessel occlusion. Read More

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http://dx.doi.org/10.4254/wjh.v12.i5.184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280862PMC

Segmental arterial mediolysis: a commonly overlooked aetiology of acute abdominal pain.

BMJ Case Rep 2020 Jun 14;13(6). Epub 2020 Jun 14.

Department of Radiology, University Of Illinois College Of Medicine, Peoria, Illinois, USA.

Segmental arterial mediolysis (SAM) is an uncommon condition and commonly missed diagnostic aetiology of acute abdominal pain, initially described in 1976. SAM is a non-inflammatory, non-atherosclerotic vasculopathy mostly involving the abdominal arteries with notable asymmetric involvement of the walls of the mesenteric arteries and their branches. Clinical presentation ranges from postprandial abdominal discomfort suggestive of mesenteric ischaemia to intra-abdominal bleeding. Read More

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http://dx.doi.org/10.1136/bcr-2020-234576DOI Listing

Ischemic postconditioning attenuates acute kidney injury following intestinal ischemia-reperfusion through Nrf2-regulated autophagy, anti-oxidation, and anti-inflammation in mice.

FASEB J 2020 Jun 10. Epub 2020 Jun 10.

Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.

Intestinal ischemia-reperfusion (IIR) often occurs during and following major cardiovascular or gut surgery and causes significant organ including kidney injuries. This study was to investigate the protective effect of intestinal ischemic postconditioning (IPo) on IIR-induced acute kidney injury (AKI) and the underling cellular signaling mechanisms with focus on the Nrf2/HO-1. Adult C57BL/6J mice were subjected to IIR with or without IPo. Read More

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http://dx.doi.org/10.1096/fj.202000274RDOI Listing
June 2020
5.043 Impact Factor

Total Pancreatectomy and Pancreatic Allotransplant in a Porcine Experimental Model.

Exp Clin Transplant 2020 Jun;18(3):353-358

From the Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.

Objectives: The main objective of this experimental study was to evaluate the feasibility of diabetes induction by total pancreatectomy and pancreatic allotransplant after diabetes induction by total pancreatectomy. The secondary objective was to evaluate metabolic (C-peptide, glycemia) and inflammatory (lactate and platelet levels) parameters after diabetes induction by total pancreatectomy and pancreatic allotransplant after total pancreatectomy.

Materials And Methods: The study protocol was approved by the French Minister of Research (APAFiS no. Read More

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http://dx.doi.org/10.6002/ect.2019.0291DOI Listing

Case report and systematic review of mesenteric artery by-pass for non-atherosclerotic mesenteric vascular disease.

Authors:
Wajiha Zahra

Int J Surg Case Rep 2020 11;70:249-250. Epub 2020 May 11.

Doncaster Royal Infirmary, Thorne Road, Doncaster DN2 5LT, United Kingdom. Electronic address:

Introduction: Mesenteric artery re-vascularization using bypass or angioplasty is a standard of care in atherosclerotic mesenteric vascular disease. However, there are no certain guidelines for the management of non-atherosclerotic thrombophilic mesenteric vessel disease other than anti-coagulation.

Case Report: We are reporting a case of a 36 years old lady with post-prandial angina and weight loss on the background of anti-phospholipid syndrome having tripple mesentric vessel occlusive disease who underwent 2 vessel aorto-mesenteric bypass. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242995PMC

Local Intra-arterial Vasodilator Infusion in Non-Occlusive Mesenteric Ischemia Significantly Increases Survival Rate.

Cardiovasc Intervent Radiol 2020 May 22. Epub 2020 May 22.

Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital, Carl Gustav Carus University, TU Dresden, Fetscherstr. 74, 01307, Dresden, Germany.

Purpose: To investigate the outcome of local intra-arterial papaverine infusion therapy in patients with non-occlusive mesenteric ischemia (NOMI), and factors influencing survival, in comparison with a conservative approach.

Methods: From 2013 to 2019, patients with NOMI confirmed by imaging were included in a retrospective two-center study. According to different in-house standard procedures, patients were treated in each center either conservatively or interventionally by a standardized local infusion of intra-arterial papaverine into the splanchnic arteries. Read More

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http://dx.doi.org/10.1007/s00270-020-02515-4DOI Listing

Inhibition of a triggering receptor expressed on myeloid cells-1 (TREM-1) with an extracellular cold-inducible RNA-binding protein (eCIRP)-derived peptide protects mice from intestinal ischemia-reperfusion injury.

Surgery 2020 May 18. Epub 2020 May 18.

Center for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY; Department of Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY; Elmezzi Graduate School of Molecular Medicine, Manhasset, NY. Electronic address:

Background: Intestinal ischemia-reperfusion injury results in morbidity and mortality from both local injury and systemic inflammation and acute lung injury. Extracellular cold-inducible RNA-binding protein is a damage associated molecular pattern that fuels systemic inflammation and potentiates acute lung injury. We recently discovered a triggering receptor expressed on myeloid cells-1 serves as a novel receptor for extracellular cold-inducible RNA-binding protein. Read More

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http://dx.doi.org/10.1016/j.surg.2020.04.010DOI Listing

Involvement of amylin B-H2S-connexin 43 signaling pathway in vascular dysfunction and enhanced ischemia-reperfusion-induced myocardial injury in diabetic rats.

Biosci Rep 2020 Jun;40(6)

Department of Cardiovascular, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650101, China.

The present study was designed to investigate the role of amylin, H2S, and connexin 43 in vascular dysfunction and enhanced ischemia-reperfusion (I/R)-induced myocardial injury in diabetic rats. A single dose of streptozotocin (65 mg/kg) was employed to induce diabetes mellitus. After 8 weeks, there was a significant decrease in the plasma levels of amylin, an increase in I/R injury to isolated hearts (increase in CK-MB and cardiac troponin release) on the Langendorff apparatus. Read More

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http://dx.doi.org/10.1042/BSR20194154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280474PMC

Long-Term Outcomes of Mesenteric Stenting and Analysis of In-Stent Restenosis Duplex Velocity Criteria.

Ann Vasc Surg 2020 May 16. Epub 2020 May 16.

Section of Vascular Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH.

Background: Endovascular therapy for chronic mesenteric ischemia (CMI) is the mainstay of treatment. Duplex velocity criteria within stented mesenteric vessels are not well established. We describe single-center outcomes of mesenteric stenting for CMI and analyze duplex velocities associated with in-stent restenosis (ISR). Read More

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http://dx.doi.org/10.1016/j.avsg.2020.04.064DOI Listing

En Bloc Celiac Axis Resection for Pancreatic Cancer: Classification of Anatomical Variants Based on Tumor Extent.

J Am Coll Surg 2020 Jul 15;231(1):8-29. Epub 2020 May 15.

Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic College of Medicine, Rochester, MN.

Background: En bloc celiac axis resection (CAR) for pancreatic cancer is considered increasingly after modern neoadjuvant chemotherapy (NAC). Appleby and distal pancreatectomy with CAR are anatomically inaccurate terms, as tumors can extend beyond celiac axis proper, requiring concurrent resection of the proper hepatic artery and/or superior mesenteric artery.

Study Design: A 3-level classification for CAR (class 1, 2, or 3) was developed after retrospective review of an arterial resection database describing anatomical variants that dictate pancreatectomy-type, formal arterial revascularization, and gastric preservation. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2020.05.005DOI Listing

Interdisciplinary Management of Visceral Artery Aneurysms and Visceral Artery Pseudoaneurysms.

Acta Medica (Hradec Kralove) 2020 ;63(1):43-48

Clinic of Vascular Surgery, East Slovak Institute of Cardiovascular Diseases, Faculty of Medicine, Pavol Jozef Šafárik University, Košice, Slovak Republic.

The paper presents the results of treating 14 patients, namely eight patients with visceral artery aneurysms and six patients with visceral artery pseudoaneurysms. In 64.3% of the patients, the initial diagnosis was made based on the ultrasound examination. Read More

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http://dx.doi.org/10.14712/18059694.2020.14DOI Listing
January 2020

Retrograde Recanalization of the Celiac Artery via the Pancreaticoduodenal Arcade as a Safe and Valid Alternative to Antegrade Access.

Vasc Endovascular Surg 2020 May 18:1538574420927132. Epub 2020 May 18.

Department of Diagnostic and Interventional Radiology, RWTH University Hospital Aachen, Aachen, Germany.

Purpose: The antegrade recanalization of an occlusion or high-grade stenosis of the celiac artery via the aorta often represents a technical challenge. A retrograde approach via the superior mesenteric artery and the pancreaticoduodenal arcade may be an alternative approach. Based on our experience, we assess the technical success and the short- and mid-term outcomes of this bailout procedure. Read More

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http://dx.doi.org/10.1177/1538574420927132DOI Listing

Short-term very low caloric intake causes endothelial dysfunction and increased susceptibility to cardiac arrhythmias and pathology in male rats.

Exp Physiol 2020 Jul 8;105(7):1172-1184. Epub 2020 Jun 8.

Department of Medicine, Georgetown University, Washington, DC, USA.

New Findings: What is the central question of this study? What are the effects of a 2 week period of severe food restriction on vascular reactivity of resistance arteries and on cardiac structure and function? What is the main finding and its importance? This study showed, for the first time, that a 2 week period of severe food restriction in adult male Fischer rats caused endothelial dysfunction in mesenteric arteries and increased the susceptibility to ischaemia-reperfusion-induced arrhythmias and cardiac pathology. Our findings might have ramifications for cardiovascular risk in people who experience periods of inadequate caloric intake.

Abstract: Severe food restriction (sFR) is a common dieting strategy for rapid weight loss. Read More

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http://dx.doi.org/10.1113/EP088434DOI Listing

Oncostatin M Plays a Critical Role in Survival after Acute Intestinal Ischemia: Reperfusion Injury.

Surg Infect (Larchmt) 2020 May 5. Epub 2020 May 5.

Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Acute intestinal ischemia-reperfusion injury (AIIRI) is a devastating clinical condition relevant to multiple diseases processes, including sepsis, trauma, transplantation, and burns. An AIIRI is a contributor to the development of multiple organ dysfunction syndrome (MODS). Oncostatin M (OSM)/oncostatin M receptor (OSMR) signaling is an unrecognized and novel candidate pathway for the mediation of MODS. Read More

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http://dx.doi.org/10.1089/sur.2019.193DOI Listing

Laser Atherectomy to Treat Severe In Stent Restenosis of the Superior Mesenteric Artery.

J Cardiol Cases 2020 May 6;21(5):176-178. Epub 2020 Feb 6.

Division of Cardiology, Department of Internal Medicine, Palmetto General Hospital, Hialeah, FL, USA.

Chronic mesenteric ischemia is an uncommon disorder in the USA. Frequently, a percutaneous approach is the first therapeutic choice to reduce its symptoms and improve outcomes. After an initial treatment with stents, further interventions might be necessary to address in-stent restenosis and re-establish a better visceral flow. Read More

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http://dx.doi.org/10.1016/j.jccase.2020.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195566PMC

The establishment of rat model in myocardial ischemia with psychological stress.

Ann Transl Med 2020 Mar;8(6):322

Out-patient Department, Chinese PLA General Hospital, Beijing 100853, China.

Background: Psychological stress can provoke and aggravate myocardial ischemia, and this stress can even trigger acute coronary syndromes or sudden cardiac death. Therefore, for the first time, this study aimed to investigate the method for establishing a rat model of myocardial ischemia with psychological stress and its evaluation.

Methods: Forty male Wistar rats were randomly divided into the sham (S, n=10), myocardial infarct (MI, n=10), psychological stress (MODEL, n=10), and myocardial infarct with psychological stress (MI + MODEL, n=10) groups. Read More

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http://dx.doi.org/10.21037/atm.2020.02.128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186656PMC

PTEN-induced kinase 1-induced dynamin-related protein 1 Ser637 phosphorylation reduces mitochondrial fission and protects against intestinal ischemia reperfusion injury.

World J Gastroenterol 2020 Apr;26(15):1758-1774

Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China.

Background: Intestinal ischemia reperfusion (I/R) occurs in various diseases, such as trauma and intestinal transplantation. Excessive reactive oxygen species (ROS) accumulation and subsequent apoptotic cell death in intestinal epithelia are important causes of I/R injury. PTEN-induced putative kinase 1 (PINK1) and phosphorylation of dynamin-related protein 1 (DRP1) are critical regulators of ROS and apoptosis. Read More

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http://dx.doi.org/10.3748/wjg.v26.i15.1758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183859PMC
April 2020
2.369 Impact Factor

Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway.

Redox Biol 2020 05 10;32:101534. Epub 2020 Apr 10.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China; Department of SICU, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China. Electronic address:

Intestinal ischemia-reperfusion (I/R) injury is a life-threatening vascular emergency and has long been a disturbing problem for surgeons. Oxidative stress is considered a vital factor in I/R injury. Metformin has anti-oxidative properties and protects against I/R injury. Read More

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http://dx.doi.org/10.1016/j.redox.2020.101534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178548PMC

Challenges Encountered during the Treatment of Acute Mesenteric Ischemia.

Gastroenterol Res Pract 2020 31;2020:5316849. Epub 2020 Mar 31.

Department of General, Gastroenterological and Oncological Surgery, Collegium Medicum Nicolaus Copernicus University, Toruń, Poland.

Results: Acute ischemia of the bowel mesentery was diagnosed in 41 patients (27 women and 14 men; mean age, 65.4 years). All patients underwent laparotomy. Read More

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http://dx.doi.org/10.1155/2020/5316849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150694PMC

Pre-operative endovascular occlusion for unresectable metastatic carcinoid tumor: technique and initial results.

Abdom Radiol (NY) 2020 Apr 21. Epub 2020 Apr 21.

Department of Radiology, Icahn School of Medicine at Mount Sinai Hospital, 1 Gustave Levy Place, Box 1234, New York, NY, 10029, USA.

Purpose: Surgery is the only curative therapy for carcinoid patients; however, many are unresectable due to direct involvement of the superior mesenteric artery (SMA) branches. In these patients, we sought to improve surgical outcomes via arterial skeletonization of the SMA prior to surgical resection.

Materials And Methods: After left radial access, the SMA was catheterized, angiography was performed, and balloon occlusion was achieved in the tumor vessel. Read More

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http://dx.doi.org/10.1007/s00261-020-02534-2DOI Listing

European guidelines on chronic mesenteric ischaemia - joint United European Gastroenterology, European Association for Gastroenterology, Endoscopy and Nutrition, European Society of Gastrointestinal and Abdominal Radiology, Netherlands Association of Hepatogastroenterologists, Hellenic Society of Gastroenterology, Cardiovascular and Interventional Radiological Society of Europe, and Dutch Mesenteric Ischemia Study group clinical guidelines on the diagnosis and treatment of patients with chronic mesenteric ischaemia.

United European Gastroenterol J 2020 May 16;8(4):371-395. Epub 2020 Apr 16.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Chronic mesenteric ischaemia is a severe and incapacitating disease, causing complaints of post-prandial pain, fear of eating and weight loss. Even though chronic mesenteric ischaemia may progress to acute mesenteric ischaemia, chronic mesenteric ischaemia remains an underappreciated and undertreated disease entity. Probable explanations are the lack of knowledge and awareness among physicians and the lack of a gold standard diagnostic test. Read More

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http://dx.doi.org/10.1177/2050640620916681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226699PMC

Chimney Technique to Preserve Visceral Flow in a Coral Reef Aorta.

Ann Vasc Surg 2020 Apr 10. Epub 2020 Apr 10.

Department of Interventional Radiology, Haga Hospital, The Hague, The Netherlands.

The coral reef aorta (CRA) is a rare phenomenon of extreme calcification in the juxtarenal and suprarenal aorta. Open revascularization has an overall in-hospital mortality rate of 13%. We present a patient with a suprarenal CRA with colon ischemia. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.03.044DOI Listing

Ribonuclease attenuates acute intestinal injury induced by intestinal ischemia reperfusion in mice.

Int Immunopharmacol 2020 Jun 9;83:106430. Epub 2020 Apr 9.

Department of Anesthesiology, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Electronic address:

Ribonuclease (RNase) reportedly exerts organ-protective effects in several pathological conditions, including ischemia reperfusion (I/R), but whether it can exhibit protective effect on intestinal I/R injury and potential mechanisms remain unknown. The present study was aimed to evaluate the effects of RNase on intestinal I/R injury and explore the underlying mechanisms. Thirty-two wild-type C57BL/6J adult male mice were evenly divided into a sham group, a sham + RNase group, an I/R group and an I/R + RNase group. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106430DOI Listing

Quantitative evaluation of superior mesenteric artery calcification in hemodialysis patients undergoing aortic valve replacement.

Gen Thorac Cardiovasc Surg 2020 Apr 10. Epub 2020 Apr 10.

Department of Cardiovascular Surgery, Teine Keijinkai Hospital, 1-12 Maeda, Teine-ku, Sapporo, 006-8555, Japan.

Objective: Postoperative acute mesenteric ischemia (AMI) in the long-term hemodialysis (HD) patients could be a disastrous complication leading to high mortality. The objective is to evaluate the association between the presence of superior mesenteric artery calcification (SMAC) and early and late outcomes after aortic valve replacement (AVR) in HD patients.

Methods: Between April 2003 and December 2018, the enrolled 46 HD patients (19 women; mean age 72 years) who underwent AVR for severe aortic valve stenosis were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s11748-020-01352-zDOI Listing

[Endovascular surgery for acute mesenteric ischemia].

Khirurgiia (Mosk) 2020 (3):61-66

Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Department of Surgery and Endoscopy of the Faculty of Additional Professional Education, Moscow, Russia; V.M. Buyanov Municipal Clinical Hospital of the Moscow Healthcare Department, Moscow, Russia.

Objective: To demonstrate the results of endovascular treatment of 15 patients with acute mesenteric ischemia.

Material And Methods: There were 15 patients with acute mesenteric ischemia who underwent surgery (9 men and 6 women). Mean age was 77±11 years. Read More

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http://dx.doi.org/10.17116/hirurgia202003161DOI Listing

Early and midterm outcomes of celiac artery coverage during thoracic endovascular aortic repair.

J Vasc Surg 2020 Apr 4. Epub 2020 Apr 4.

Division of Vascular Surgery, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: In thoracic endovascular aortic repair (TEVAR), covering the celiac artery (CA) is sometimes necessary to secure the distal seal. We report the outcomes of planned CA coverage in our experience with TEVAR.

Methods: Cases requiring CA coverage during TEVAR from October 2008 to September 2018 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.jvs.2020.02.025DOI Listing

A Short Series of Laparoscopic Mesenteric Bypasses for Chronic Mesenteric Ischemia.

Vasc Health Risk Manag 2020 20;16:87-97. Epub 2020 Mar 20.

Department of Vascular Surgery, Heart, Lung and Vascular Clinic, Oslo University Hospital Aker, Oslo, Norway.

Background: Laparoscopic aortomesenteric bypass may be performed to treat the chronic mesenteric ischemia patients who are not suitable for endovascular treatment. This study presents an initial experience with a limited series of laparoscopic mesenteric artery revascularization for the treatment of mesenteric ischemia.

Methods: Chronic mesenteric ischemia (CMI) patients with previous unsuccessful endovascular treatment or with arterial occlusion and extensive calcification precluding safe endovascular treatment were offered laparoscopic mesenteric revascularization. Read More

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http://dx.doi.org/10.2147/VHRM.S243264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098165PMC

Gallbladder necrosis and small bowel ischaemia following fenestrated endovascular aneurysm repair for juxtarenal abdominal aortic aneurysm: a case report.

J Surg Case Rep 2020 Mar 24;2020(3):rjaa046. Epub 2020 Mar 24.

Department of Vascular Surgery, Aberdeen Royal Infirmary, Aberdeen, UK.

Anatomical variation may result in unexpected complications after fenestrated endovascular aneurysm repair (FEVAR). We report a 78-year-old gentleman who was admitted for elective FEVAR procedure for a juxtarenal abdominal aortic aneurysm. Three days post-operatively, he deteriorated clinically. Read More

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http://dx.doi.org/10.1093/jscr/rjaa046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092683PMC

The intestinal injury caused by ischemia-reperfusion is attenuated by amniotic fluid stem cells via the release of tumor necrosis factor-stimulated gene 6 protein.

FASEB J 2020 May 29;34(5):6824-6836. Epub 2020 Mar 29.

Division of General and Thoracic Surgery, Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada.

Ischemia/reperfusion (I/R) is implicated in the pathogenesis of various acute intestinal injuries. Amniotic fluid stem cells (AFSC) are beneficial in experimental intestinal diseases. Tumor necrosis factor-induced protein 6 (TSG-6) has been shown to exert anti-inflammatory effects. Read More

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http://dx.doi.org/10.1096/fj.201902892RRDOI Listing
May 2020
5.043 Impact Factor

Terlipressin Increases Systemic and Lowers Pulmonary Arterial Pressure in Experimental Acute Pulmonary Embolism.

Crit Care Med 2020 Apr;48(4):e308-e315

Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.

Objectives: We investigated whether the vasopressin-analog, terlipressin induces systemic vasoconstriction and pulmonary vasodilation in a porcine model of acute pulmonary embolism.

Design: Controlled, animal study.

Setting: Tertiary medical center research laboratory. Read More

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http://dx.doi.org/10.1097/CCM.0000000000004243DOI Listing

Review Article: Mesenteric Ischemia.

Curr Gastroenterol Rep 2020 Mar 17;22(4):17. Epub 2020 Mar 17.

Division of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA.

Purpose Of Review: Mesenteric ischemia (MI), both acute (AMI) and chronic (CMI), is a challenging diagnosis to make, and early diagnosis and treatment are vital to improve outcomes. This manuscript summarizes the most up to date information on diagnosis and treatment of these disorders.

Recent Findings: There have been several significant advancements in the computed tomography (CT) diagnostic imaging as well as medical and endovascular management of AMI and CMI. Read More

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http://dx.doi.org/10.1007/s11894-020-0754-xDOI Listing

Glutamine protects intestine against ischemia-reperfusion injury by alleviating endoplasmic reticulum stress induced apoptosis in rats.

Acta Cir Bras 2020 9;35(1):e202000104. Epub 2020 Mar 9.

MD, Department of Gastrointestinal Surgery, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, PR China. Conception and design of the study, analysis and interpretation of data, critical revision,final approval.

Purpose: Glutamine, as an essential part of enteral nutrition and parenteral nutrition agent, has been widely recognized to be a kind of important intestinal mucosa protectant in clinical practice and experimental research. However, the mechanisms of its protective effects are still not fully understand. Consequently, this study aimed to explore the potential mechanism of glutamine on ischemia-reperfusion (I/R) injury induced endoplasmic reticulum (ER) stress in intestine. Read More

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http://dx.doi.org/10.1590/s0102-865020200010000004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065443PMC
March 2020
0.570 Impact Factor

Split-bolus CTA for mesenteric ischemia with a single scan opacifying arterial and mesenteric venous systems.

Eur Radiol 2020 Jul 10;30(7):3987-3995. Epub 2020 Mar 10.

Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA, 02215, USA.

Objective: To evaluate the diagnostic accuracy of split-bolus single-scan computed tomography angiography (CTA) protocol for evaluation of acute mesenteric ischemia and alternate diagnoses.

Materials And Methods: In this IRB-approved, HIPAA-compliant retrospective study, consecutive patients from 21 October 2016 to 6 May 2018 evaluated for mesenteric ischemia with split-bolus CTA (a single scan in concurrent arterial and portal venous phase) in a single tertiary academic institution were included. Intravenous contrast was administered on weight-based basis. Read More

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http://dx.doi.org/10.1007/s00330-020-06769-xDOI Listing

Renal and Mesenteric Artery Intervention.

Interv Cardiol Clin 2020 04 31;9(2):169-185. Epub 2020 Jan 31.

Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Center, Ochsner Medical Center, The Ochsner Clinical School, University of Queensland, 1514 Jefferson Highway, New Orleans, LA 70121, USA; Department of Cardiology, Ochsner Medical Center, 3rd Floor, 1514 Jefferson Highway, New Orleans, LA 70121, USA. Electronic address:

Atherosclerotic renal artery stenosis is the most common cause of secondary hypertension and may cause progressive renal disease and cardiac destabilization syndromes. Guideline-directed medical therapy is advised in all patients. Patients with refractory symptoms and hemodynamically significant stenoses are more likely to benefit from renal artery stent placement. Read More

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http://dx.doi.org/10.1016/j.iccl.2019.11.002DOI Listing

Recanalization using direct stenting before bowel resection for acute-on-chronic superior mesenteric artery occlusion: A case report.

Int J Surg Case Rep 2020 21;68:92-95. Epub 2020 Feb 21.

Emergency and Intensive Care Center, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara, Chiba, 299-0111, Japan.

Introduction: Acute-on-chronic mesenteric ischemia (ACMI) refers to acute mesenteric ischemia (AMI) developing in a patient displaying typical symptoms of chronic mesenteric ischemia (CMI). Delayed treatment can cause short bowel syndrome and increased mortality. Intervention involves intestinal revascularization and resection of the necrotic intestine. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.02.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052432PMC
February 2020

Total resuscitative endovascular balloon occlusion of the aorta causes inflammatory activation and organ damage within 30 minutes of occlusion in normovolemic pigs.

BMC Surg 2020 Mar 2;20(1):43. Epub 2020 Mar 2.

Department of Cardiothoracic and Vascular Surgery, Faculty of Medicine and Health, Örebro University, SE-70185, Örebro, Sweden.

Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) causes physiological, metabolic, end-organ and inflammatory changes that need to be addressed for better management of severely injured patients. The aim of this study was to investigate occlusion time-dependent metabolic, end-organ and inflammatory effects of total REBOA in Zone I in a normovolemic animal model.

Methods: Twenty-four pigs (25-35 kg) were randomized to total occlusion REBOA in Zone I for either 15, 30, 60 min (REBOA15, REBOA30, and REBOA60, respectively) or to a control group, followed by 3-h reperfusion. Read More

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http://dx.doi.org/10.1186/s12893-020-00700-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053141PMC

Diagnosis of Acute Mesenteric Ischemia in a Patient with End-Stage Renal Disease with Normal Serum Lactate.

Cureus 2020 Jan 20;12(1):e6708. Epub 2020 Jan 20.

Internal Medicine, AdventHealth, Orlando, USA.

Acute mesenteric ischemia (AMI) is a life-threatening vascular emergency and a diagnostic challenge for physicians. It represents a group of pathophysiologic processes that have a common end point, that is, bowel infarction, and has a nonspecific clinical picture and a high mortality rate. The most common underlying etiologies are arterial embolism, arterial thrombosis, nonocclusive mesenteric ischemia (NOMI), and mesenteric venous thrombosis. Read More

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http://dx.doi.org/10.7759/cureus.6708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029830PMC
January 2020

Non-occlusive mesenteric ischemia (NOMI): evaluation of 2D-perfusion angiography (2D-PA) for early treatment response assessment.

Abdom Radiol (NY) 2020 Feb 26. Epub 2020 Feb 26.

Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Purpose: To evaluate the feasibility of 2D-perfusion angiography (2D-PA) for the analysis of intra-procedural treatment response after intra-arterial prostaglandin E1 therapy in patients with non-occlusive mesenteric ischemia (NOMI).

Methods: Overall, 20 procedures in 18 NOMI patients were included in this retrospective case-control study. To evaluate intra-procedural splanchnic circulation changes, post-processing of digital subtraction angiography (DSA) series was performed. Read More

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http://dx.doi.org/10.1007/s00261-020-02457-yDOI Listing
February 2020

Naturally shrunk visceral artery aneurysms by stenting for the superior mesenteric artery occlusion.

Minim Invasive Ther Allied Technol 2020 Feb 26:1-5. Epub 2020 Feb 26.

Department of Radiology, Shiga University of Medical Science, Shiga, Japan.

A 77-year-old woman who had experienced postprandial abdominal pain for four years was admitted to our institution presenting sudden and severe abdominal pain. Contrast-enhanced computed tomography (CECT) demonstrated complete short-segmented occlusion in the orifice of the superior mesenteric artery (SMA), and saccular aneurysms in the right hepatic artery and the anterior superior pancreaticoduodenal artery. She was diagnosed with abdominal angina due to occlusion of the SMA. Read More

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http://dx.doi.org/10.1080/13645706.2020.1732426DOI Listing
February 2020

The role of emergency presentation and revascularization in aneurysms of the peripancreatic arteries secondary to celiac trunk or superior mesenteric artery occlusion.

J Vasc Surg 2020 Jul 21;72(1S):46S-55S. Epub 2020 Feb 21.

Department of General and Vascular Surgery, University and Spedali Civili Hospital of Brescia, Brescia, Italy.

Objective: The goal of this study was to analyze our 10-year experience in the treatment of aneurysms of the collateral circulation secondary to steno-occlusions of the celiac trunk (CT) or superior mesenteric artery (SMA).

Methods: In the last 10 years, 32 celiac-mesenteric aneurysms were detected (25 true aneurysms and seven pseudoaneurysms) in 25 patients with steno-occlusion of the CT or SMA. All cases were diagnosed and treated at our center, with either surgical or endovascular approach. Read More

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http://dx.doi.org/10.1016/j.jvs.2019.11.051DOI Listing

Combined surgical treatment of symptomatic carotid, coronary and mesenteric occlusive disease.

J Surg Case Rep 2020 Feb 12;2020(2):rjz392. Epub 2020 Feb 12.

Divisions of Cardiac and Vascular Surgery, Department of Cardiovascular Sciences, Brody School of Medicine, East Carolina Heart Institute at East Carolina University, Greenville, NC, USA.

The surgical management of advanced symptomatic atherosclerotic disease in multiple distributions including the coronary circulation presents unique challenges due to the high risk of perioperative ischemic complications in the setting of coronary artery bypass grafting. We present a novel case of the combined surgical management of symptomatic carotid, coronary and mesenteric ischemic disease. The patient underwent carotid endarterectomy followed by combined coronary and mesenteric revascularization using cardiopulmonary bypass during the same hospital admission. Read More

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http://dx.doi.org/10.1093/jscr/rjz392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015075PMC
February 2020

Occlusion of the Celiac Artery during Endovascular Thoracoabdominal Aortic Aneurysm Repair Is associated with Increased Perioperative Morbidity and Mortality.

Ann Vasc Surg 2020 Jul 5;66:200-211. Epub 2020 Feb 5.

Division of Vascular Surgery, Medical University of South Carolina, Charleston, SC.

Background: Some studies suggest that celiac artery coverage during elective endovascular thoracoabdominal aortic aneurysm (TAAA) repair is safe given sufficient collateralization of visceral organ perfusion from the superior mesenteric artery. However, there is concern that celiac artery coverage may lead to increased risk of foregut or spinal cord ischemia with an attendant increased risk of mortality. We sought to investigate rates of bowel ischemia, spinal cord ischemia, and 30-day mortality associated with celiac artery coverage during TEVAR and complex EVAR. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.01.102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311253PMC