7,018 results match your criteria Merkel Cell Tumors of the Head and Neck


Concurrent Hairy Cell Leukemia and Metastatic Merkel Cell Carcinoma.

Case Rep Oncol Med 2018 14;2018:1736854. Epub 2018 Nov 14.

Specialist Care Australia, Launceston, Tasmania, Australia.

Hairy cell leukemia (HCL) and Merkel cell carcinoma (MCC) are two rare malignancies with distinct cells of origin. HCL is a lymphoid malignancy of mature B cells, and MCC derives from neuroendocrine cell origin. HCL has a favorable prognosis with most patients achieving long-term remission and potential cure. Read More

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November 2018
2 Reads

Comparison of the quality of B-scan ultrasound in modern high-end devices.

Z Gastroenterol 2018 Dec 10;56(12):1491-1498. Epub 2018 Dec 10.

Abt. f. Innere Medizin, Immanuel Klinik Rudersdorf, Rüdersdorf b. Berlin, Germany.

Purpose:  The quality of an ultrasound device's B-scan mode is decisive in obtaining clear and informative images. High demands are placed upon ultrasound devices, particularly in cases where evidence of small lesions of parenchymal organs is being gathered.

Methods:  We tested the quality of the B-scan mode in ultrasound devices of 7 different manufacturers. Read More

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December 2018

Monitoring response of advanced Merkel cell carcinoma to Avelumab with F-FDG PET/CT.

Eur J Nucl Med Mol Imaging 2018 Dec 7. Epub 2018 Dec 7.

Nuclear Medicine Unit, ICS Maugeri SpA SB IRCCS, Pavia, Italy.

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December 2018

Statistical analysis of the usefulness of follicle-sinus complexes as a novel diagnostic material for canine rabies.

J Vet Med Sci 2018 Dec 7. Epub 2018 Dec 7.

Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University.

In the present study, follicle-sinus complexes (FSCs) were harvested from the muzzle skin of 123 dogs with suspected canine rabies, and the sensitivity and specificity of FSC analysis were compared with those of brain tissue immunohistochemistry analysis. In the FSCs, viral antigen was detected from Merkel cells. Sensitivity was 97. Read More

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December 2018

Human Oncoviruses: Mucocutaneous Manifestations, Pathogenesis, Therapeutics, and Prevention (Part I: Papillomaviruses and Merkel cell polyomavirus).

J Am Acad Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Center for Clinical Studies, Houston, TX, USA; Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA.

In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Read More

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November 2018
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Human Oncoviruses: Mucocutaneous Manifestations, Pathogenesis, Therapeutics, and Prevention (Part II: Hepatitis Viruses, Human T-cell Leukemia Viruses, Herpesviruses, and Epstein-Barr Virus).

J Am Acad Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Center for Clinical Studies, Houston, TX, USA; Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA.

In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Read More

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November 2018
1 Read

Prognostic subdivision of pT2 rectal carcinomas.

Int J Colorectal Dis 2018 Dec 4. Epub 2018 Dec 4.

Department of Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstr. 12, 91054, Erlangen, Germany.

Purpose: The aim of the present study is to explore the prognostic impact of a subdivision of pT2 by the depth of invasion into the muscularis propria in rectal carcinomas.

Methods: Data from 269 consecutive patients with rectal carcinoma treated with primary tumor resection and lymph node dissection between 1986 and 2012 were analyzed with respect to locoregional and distant recurrence, disease-free survival, and overall survival. The depth of invasion into the muscularis propria of pT2 carcinomas was categorized by the pathologist into two groups: pT2a, invasion into the inner half of the muscularis propria; pT2b, invasion into the outer half of the muscularis propria. Read More

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December 2018
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Epigenetic regulation of gene expression in Chinese Hamster Ovary cells in response to the changing environment of a batch culture.

Biotechnol Bioeng 2018 Dec 4. Epub 2018 Dec 4.

University of Natural Resources and Life Sciences Vienna, Austria.

The existence of dynamic cellular phenotypes in changing environmental conditions is of major interest for cell biologists aiming to understand the mechanism and sequence of regulation of gene expression. In the context of therapeutic protein production by Chinese Hamster Ovary (CHO) cells, a detailed temporal understanding of cell-line behavior and control is necessary to achieve more predictable and reliable process performance. Of particular interest are data on dynamic, temporally resolved transcriptional regulation of genes in response to altered substrate availability and culture conditions. Read More

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December 2018
3 Reads

Prevalence and association of human papillomavirus, Epstein-Barr virus and Merkel Cell polyomavirus with neoplastic esophageal lesions in northern Iran.

Caspian J Intern Med 2018 ;9(4):353-360

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Background: Studies concerning on esophageal squamous cell carcinoma (ESCC) etiological factors have been done for several decades, however, results reported from various investigations were not consistent. The present investigation aimed to explore the presence of 3 oncogenic viruses, human papilloma virus (HPV), Epstein-Barr virus (EBV) and Merkel cell polyomavirus (MCPyV) in the neoplastic and non- neoplastic esophageal lesions collected from Mazandaran, a high risk area of Iran.

Methods: In total, 168 esophageal specimens (100 with ESCC confirmed diagnosis and 68 without esophageal malignancy) were analyzed for HPV, EBV and MCPyV by Real Time PCR. Read More

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January 2018
2 Reads

A Spontaneous Regression of an Isolated Lymph Node Metastasis from a Primary Unknown Merkel Cell Carcinoma in a Patient with an Idiopathic Hyper-Eosinophilic Syndrome.

Am J Case Rep 2018 Dec 4;19:1437-1440. Epub 2018 Dec 4.

Division of Medical Oncology, Centre Hospitalier Régional (CHR) Metz-Thionville, Ars-Laquenexy, France.

BACKGROUND Merkel cell carcinoma (MCC) is a rare, aggressive primary cutaneous neuroendocrine tumor frequently associated with Merkel cell polyomavirus infection. Despite its aggressiveness, a few reports of spontaneous MCC regression have been described in the literature, most of them following incisional biopsy supporting a hypothetical role of surgery-induced inflammation in the process of regression. CASE REPORT We report a case of 69-year-old Caucasian male who was followed for an idiopathic hyper-eosinophilic syndrome. Read More

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December 2018
3 Reads

Editorial: Human Papillomaviruses and Polyomaviruses in Skin Cancer.

Front Microbiol 2018 15;9:2778. Epub 2018 Nov 15.

Institute of Virology, Saarland University, Saarbrücken, Germany.

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November 2018

Merkel Cell Carcinoma Review.

Hematol Oncol Clin North Am 2019 Feb;33(1):39-52

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02215, USA; Department of Dermatology, Center for Cutaneous Oncology, Dana-Farber/Brigham and Women's Cancer Center, 450 Brookline Avenue, Boston, MA 02115, USA. Electronic address:

Merkel cell carcinoma is a rare and aggressive cutaneous malignancy of neuroendocrine origin-an often-missed diagnosis due to the wide histopathologic differential diagnosis of malignant small blue cell tumors. The advent of electron microscopy and immunohistochemistry staining for cytokeratin 20, a shared neuroendocrine marker, greatly improved diagnostic accuracy. Over the past decade, staging, treatment, and surveillance of the cancer have progressed at a remarkably rapid pace. Read More

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February 2019

Merkel cells touch a nerve.

Authors:
Natasha Bray

Nat Rev Neurosci 2018 Nov 28. Epub 2018 Nov 28.

Nature Reviews Neuroscience, .

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November 2018

Management of Regional Lymph Nodes in Patients with Merkel Cell Carcinoma Following a Positive Sentinel Node Biopsy: Less May be More, But is Either Enough?

Ann Surg Oncol 2018 Nov 27. Epub 2018 Nov 27.

Faculty of Medicine and Health Sciences, The University of Sydney, Sydney, NSW, Australia.

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November 2018

Inter- and intraobserver reliability and critical analysis of the FFP classification of osteoporotic pelvic ring injuries.

Injury 2018 Nov 15. Epub 2018 Nov 15.

Department of Trauma Surgery, Medical University of Innsbruck, Austria. Electronic address:

Introduction: The classification and management of osteoporotic pelvic ring injuries (OPRI) remain challenging. The fragility fractures of the pelvis (FFP) classification system proposed by Rommens and Hofmann constitutes the first comprehensive classification system of OPRI and may contribute to a more thorough assessment and grading of these injuries. The reliability of the FFP classification system, however, has not been evaluated yet. Read More

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November 2018

Merkel cell polyomavirus-specific immune responses in patients with Merkel cell carcinoma receiving anti-PD-1 therapy.

J Immunother Cancer 2018 Nov 27;6(1):131. Epub 2018 Nov 27.

Department of Medicine, Divisions of Dermatology and Medical Oncology, University of Washington, 850 Republican Street, Seattle, WA, 98109, USA.

Background: Merkel cell carcinoma (MCC) is an aggressive skin cancer that frequently responds to anti-PD-1 therapy. MCC is associated with sun exposure and, in 80% of cases, Merkel cell polyomavirus (MCPyV). MCPyV-specific T and B cell responses provide a unique opportunity to study cancer-specific immunity throughout PD-1 blockade therapy. Read More

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November 2018

Product review: avelumab, an anti-PD-L1 antibody.

Hum Vaccin Immunother 2018 Nov 27. Epub 2018 Nov 27.

a Medical Oncology Service, Center for Cancer Research , National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.

Although immunotherapies have been employed for many decades, immune checkpoint inhibitors have only recently entered the oncologic landscape. Avelumab is a fully human monoclonal antibody that blocks the interaction between PD-L1 on tumor cells and PD-1 on T cells, thereby inhibiting immunosuppression in the tumor microenvironment and reducing tumor growth. Most early clinical trials of avelumab as monotherapy and in combination regimens were part of the international JAVELIN clinical trial program, which included more than 7000 patients in more than 30 trials with at least 15 tumor types. Read More

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November 2018
2 Reads

Changing the Way of Entrance: Highly Efficient Transfer of mRNA and siRNA via Fusogenic Nano-Carriers.

J Biomed Nanotechnol 2019 Jan;15(1):170-183

Transferring nucleic acids into mammalian cells heavily influences life science for decades. While first applications mainly dealt with DNA transfer for various purposes as e.g. Read More

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January 2019

Soluble intercellular adhesion molecule-1 is a prognostic marker in colorectal carcinoma.

Int J Colorectal Dis 2018 Nov 23. Epub 2018 Nov 23.

Department of Surgery, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Krankenhausstr. 12, 91054, Erlangen, Germany.

Purpose: Serological tumor markers are routinely used to monitor tumor onset and progression. In colorectal carcinoma (CRC), the carcinoembryonic antigen (CEA) is roughly elevated in 50% of patients at initial diagnosis. Soluble ICAM-1 (sICAM-1) is elevated in different cancers. Read More

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November 2018
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The Biology and Clinical Features of Cutaneous Polyomaviruses.

J Invest Dermatol 2018 Nov 20. Epub 2018 Nov 20.

Department of Dermatology, The University of Texas Southwestern Medical Center, Department of Dermatology, Dallas, Texas, USA. Electronic address:

Human polyomaviruses are double-stand DNA viruses with a conserved genomic structure, yet they present with diverse tissue tropisms and disease presentations. Merkel cell polyomavirus, trichodysplasia spinulosa polyomavirus, human polyomavirus 6 and 7, and Malawi polyomavirus are shed from the skin, and Merkel cell polyomavirus, trichodysplasia spinulosa polyomavirus, human polyomavirus 6 and 7 have been linked to specific skin diseases. We present an update on the genomic and clinical features of these cutaneous polyomaviruses. Read More

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November 2018

The prevalence and transcriptional activity of the mucosal microbiota of ulcerative colitis patients.

Sci Rep 2018 Nov 22;8(1):17278. Epub 2018 Nov 22.

Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.

Active microbes likely have larger impact on gut health status compared to inactive or dormant microbes. We investigate the composition of active and total mucosal microbiota of treatment-naïve ulcerative colitis (UC) patients to determine the microbial picture at the start-up phase of disease, using both a 16S rRNA transcript and gene amplicon sequencing. DNA and RNA were isolated from the same mucosal colonic biopsies. Read More

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November 2018
4 Reads

Utilization of Indocyanine Green to Aid in Identifying Sentinel Lymph Nodes in Merkel Cell Cancer.

J Surg Res 2018 Dec 18;232:365-368. Epub 2018 Jul 18.

Cleveland Clinic Foundation, Department of Plastic Surgery, Cleveland, Ohio. Electronic address:

Background: Merkel cell carcinoma (MCC) is a relatively rare skin cancer with high rates of regional lymph node involvement and metastatic spread. National Comprehensive Cancer Network guidelines recommend sentinel lymph node biopsy (SLNB) for staging purposes. The goal of this study is to report our experience utilizing indocyanine green (ICG) fluorescence-based technology to aid in SLNB detection in MCC. Read More

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December 2018
1 Read

Concurrent Metastatic Merkel Cell Carcinoma and Cutaneous Squamous Cell Carcinoma in the Same Lymph Node.

Am J Dermatopathol 2018 Nov 15. Epub 2018 Nov 15.

Department of Pathology/Dermatopathology, Wake Forest School of Medicine, Winston-Salem, NC.

The coexistence of Merkel cell carcinoma (MCC) and squamous cell carcinoma (SCC) in the same cutaneous lesion is well known. The pathogenesis is believed to be distinct from conventional polyomavirus-related MCC, and it has a more aggressive course. Metastasis of MCC and SCC to the same lymph node is exceedingly rare with only one previously reported case in the English literature. Read More

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November 2018
1 Read

Cardiovascular risk factors and incident giant cell arteritis: a population-based cohort study.

Scand J Rheumatol 2018 Nov 21:1-5. Epub 2018 Nov 21.

h Division of Rheumatology , University of Pennsylvania , Philadelphia , PA , USA.

Objective: To assess the strength of the effect of cardiovascular risk factors on the incidence of giant cell arteritis (GCA) in a general population context.

Method: Data from the Reykjavik Study (RS), a population-based cohort study focusing on cardiovascular disease, were used. Everyone born in 1907-1935 living in Reykjavik, Iceland, or adjacent communities on 1 December 1967 were invited to participate. Read More

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November 2018
4 Reads

Evidence of proliferative activity in human Merkel cells: implications in the histogenesis of Merkel cell carcinoma.

Arch Dermatol Res 2018 Nov 20. Epub 2018 Nov 20.

Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, 849-8501, Japan.

The cellular origin of Merkel cell carcinoma (MCC) is controversial. We previously hypothesized that MCC originates from hair follicle stem cells or Merkel cell (MC) progenitors residing within the hair follicle bulge. Examination of three cases of combined MCC led to the unexpected discovery that numerous keratin 20 (CK20)-positive MCs within the squamous cell carcinoma (SCC) component of combined MCC appeared morphologically normal with dendritic and oval shapes. Read More

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November 2018
1 Read

[Thyroid medicine for ENT physicians].

HNO 2018 Dec;66(12):937-950

Klinik für Hals‑, Nasen‑, Ohrenheilkunde und plastische Operationen, Asklepios Klinik St. Georg, Lohmühlenstraße 5, 20099, Hamburg, Deutschland.

Diseases of the thyroid gland are frequent incidental findings during ultrasound examination of the neck. They affect nearly one third of the normal population. Treatment is not always indicated; however, laboratory diagnostic measures must be initiated to specify the disease. Read More

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December 2018
3 Reads

A novel report of a primary Merkel cell carcinoma lesion in the nasal vestibule.

Clin Case Rep 2018 Nov 12;6(11):2033-2036. Epub 2018 Sep 12.

Merkel cell carcinoma (MCC) accounts for less than 1% of cutaneous malignancies. As the lesion may mimic benign entities, clinicians' differential should include rare entities to improve outcomes by early intervention. We present a case of primary MCC in the nasal vestibule requiring partial rhinectomy, suprahyoid lymphadenectomy, and radiation therapy. Read More

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November 2018

Long-Term Follow-Up of Y-Ibritumomab Tiuxetan, Fludarabine, and Total Body Irradiation-Based Nonmyeloablative Allogeneic Transplant Conditioning for Persistent High-Risk B Cell Lymphoma.

Biol Blood Marrow Transplant 2018 Nov 3;24(11):2211-2215. Epub 2018 Jul 3.

Department of Medicine, Division of Medical Oncology, University of Washington, Seattle, Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Electronic address:

Nonmyeloablative allogeneic hematopoietic cell transplantation (HCT) can provide prolonged remissions in patients with advanced B cell lymphoma (B-NHL) via the graft-versus-lymphoma effect, although inferior results are seen in patients with chemoresistant, bulky, or aggressive disease. Radioimmunotherapy can safely induce responses in B-NHL with minimal nonhematologic toxicity. Initial results of Y-ibritumomab tiuxetan-based allografting demonstrated early safety and disease control in nonremission patients but with short follow-up. Read More

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November 2018
2 Reads

Investigation of the Diagnostic Precision and Utility of Sentinel Lymph Node Biopsy in the Treatment of Patients with Merkel Cell Carcinoma.

Am Surg 2018 May;84(5):e173-e175

Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.

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Anti-PD1 in Merkel cell carcinoma and cutaneous squamous cell carcinoma, description of five cases and recent data from the literature.

J Eur Acad Dermatol Venereol 2018 Nov 19. Epub 2018 Nov 19.

Department of Dermato-oncology, CHU Nantes, Nantes, France.

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November 2018
2 Reads

Definitive radiotherapy for Merkel cell carcinoma in the setting of epidermolysis bullosa simplex.

Australas J Dermatol 2018 Nov 18. Epub 2018 Nov 18.

Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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November 2018

Talimogene laherparepvec in combination with pembrolizumab leads to a complete response in a patient with refractory Merkel cell carcinoma.

JAAD Case Rep 2018 Nov 7;4(10):1004-1006. Epub 2018 Nov 7.

University of Southern California, Los Angeles, California.

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November 2018
1 Read

Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR Trial.

Ann Emerg Med 2018 Nov 14. Epub 2018 Nov 14.

Department of Emergency Medicine, University of Texas Health Science Center at Houston, Houston, TX.

Study Objective: The transfusion of older packed RBCs may be harmful in critically ill patients. We seek to determine the association between packed RBC age and mortality among trauma patients requiring massive packed RBC transfusion.

Methods: We analyzed data from the Pragmatic, Randomized Optimal Platelet and Plasma Ratios trial. Read More

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November 2018
8 Reads

Typically Atypical: Merkel Cell Carcinoma.

Am J Med 2018 Nov 15. Epub 2018 Nov 15.

Division of Dermatology, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus. Electronic address:

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November 2018

Evaluation of β-Sitosterol Loaded PLGA and PEG-PLA Nanoparticles for Effective Treatment of Breast Cancer: Preparation, Physicochemical Characterization, and Antitumor Activity.

Pharmaceutics 2018 Nov 15;10(4). Epub 2018 Nov 15.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilian University of Munich, Butenandtstr. 5-13, 81377 Munich, Germany.

β-Sitosterol (β-Sit) is a dietary phytosterol with demonstrated anticancer activity against a panel of cancers, but its poor solubility in water limits its bioavailability and therapeutic efficacy. In this study, poly(lactide-co-glycolic acid) (PLGA) and block copolymers of poly(ethylene glycol)-block-poly(lactic acid) (PEG-PLA) were used to encapsulate β-Sit into nanoparticles with the aim of enhancing its in vitro anticancer activity. β-Sitosterol-loaded PLGA and PEG-PLA nanoparticles (β-Sit-PLGA and β-Sit-PEG-PLA) were prepared by using a simple emulsion-solvent evaporation technique. Read More

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November 2018
2 Reads

Regulation of LDHB Plays Distinct Roles in Polyomavirus-Positive and -Negative Merkel Cell Carcinoma.

Cancers (Basel) 2018 Nov 14;10(11). Epub 2018 Nov 14.

Department of Oncology-Pathology, Karolinska Institutet, SE-17176 Stockholm, Sweden.

() is deregulated in multiple tumor types and regulates important targets involved in tumorigenesis and metastasis. This miRNA is highly expressed in Merkel cell carcinoma (MCC) compared to normal skin and other non-MCC skin cancers, and its expression is high in Merkel cell polyomavirus (MCPyV)-positive (MCPyV+) and low in MCPyV-negative (MCPyV-) MCC tumors. In this study, we characterized the function and target of in MCPyV+ and MCPyV- MCC cell lines. Read More

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November 2018

Heterogeneity of PD-L1 Expression in a Case of Merkel Cell Carcinoma Exhibiting Complete Regression After Multiple Metastases.

Br J Dermatol 2018 Nov 15. Epub 2018 Nov 15.

Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Merkel cell carcinoma (MCC) is a highly malignant skin cancer with a propensity for local recurrence and regional lymph node metastases. Once recurrence occurs, tumour progression becomes hard to be controlled. Overexpression of programmed death-ligand 1 (PD-L1) in MCC correlates with better clinical outcomes, in contrast to other solid carcinomas, e. Read More

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November 2018
3 Reads

Letter re: Efficacy of isolated limb perfusion (ILP) in patients with Merkel cell carcinoma: A multicenter experience.

Eur J Surg Oncol 2018 Nov 2. Epub 2018 Nov 2.

Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia; Discipline of Surgery, The University of Sydney, Sydney, NSW, Australia; Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia. Electronic address:

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November 2018

Radiotherapy for Skin Cancers of the Face, Head, and Neck.

Facial Plast Surg Clin North Am 2019 Feb;27(1):131-138

Department of Radiation Oncology, University of Michigan, 1500 East Medical Center Boulevard, Ann Arbor, MI 48109, USA. Electronic address:

Radiotherapy plays a role in the definitive or adjuvant management of early and late stage skin cancers including nonmelanoma basal cell carcinoma and cutaneous squamous cell carcinoma, melanoma, and Merkel cell carcinoma. The role of radiotherapy in skin cancers of the head and neck is reviewed including early and advanced-stage nonmelanoma skin cancers, melanoma, and Merkel cell carcinoma. In particular, the indications, oncologic outcomes, and technical aspects of radiotherapy for these diseases are discussed. Read More

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February 2019
5 Reads

Nonmelanoma Skin Cancer.

Facial Plast Surg Clin North Am 2019 Feb;27(1):1-13

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Schulich School of Medicine, Western University, St Joseph's Hospital, 268 Grosvenor Street 2nd Floor, London, Ontario N6A 4V2, Canada.

This article reviews the most common nonmelanoma skin cancers affecting the head and neck region. Although the most common of these malignancies rarely result in mortality, local morbidity caused by the tumors and their extirpation cannot be underestimated. Complete tumor extirpation with pathologically confirmed negative margins is the gold standard. Read More

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February 2019
4 Reads

Quantitative EEG After Subarachnoid Hemorrhage Predicts Long-Term Functional Outcome.

J Clin Neurophysiol 2018 Nov 8. Epub 2018 Nov 8.

Departments of Neurology and.

Purpose: Delayed cerebral ischemia is a major complication after subarachnoid hemorrhage. Our previous study showed that alpha power reduction in continuous quantitative EEG predicts delayed cerebral ischemia. In this prospective cohort, we aimed to determine the prognostic value of alpha power in quantitative EEG for the long-term outcome of patients with subarachnoid hemorrhage. Read More

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November 2018
9 Reads

A case of combined Merkel cell carcinoma and squamous cell carcinoma: Molecular insights and diagnostic pitfalls.

JAAD Case Rep 2018 Nov 3;4(10):996-999. Epub 2018 Nov 3.

Department of Pathology, University of Michigan, Ann Arbor, Michigan.

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November 2018
5 Reads

Merkel Cells Activate Sensory Neural Pathways through Adrenergic Synapses.

Neuron 2018 Nov 6. Epub 2018 Nov 6.

Department of Physiology & Cellular Biophysics, Columbia University, New York, NY, USA; Program in Neurobiology & Behavior, Columbia University, New York, NY, USA; Department of Dermatology, Columbia University, New York, NY, USA. Electronic address:

Epithelial-neuronal signaling is essential for sensory encoding in touch, itch, and nociception; however, little is known about the release mechanisms and neurotransmitter receptors through which skin cells govern neuronal excitability. Merkel cells are mechanosensory epidermal cells that have long been proposed to activate neuronal afferents through chemical synaptic transmission. We employed a set of classical criteria for chemical neurotransmission as a framework to test this hypothesis. Read More

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November 2018
1 Read

Neuroendocrine Key Regulator Gene Expression in Merkel Cell Carcinoma.

Neoplasia 2018 Dec 7;20(12):1227-1235. Epub 2018 Nov 7.

Department of Pathology, GROW-School for Oncology & Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address:

Merkel cell carcinoma (MCC) is a highly aggressive non-melanoma skin cancer of the elderly which is associated with the Merkel cell polyomavirus (MCPyV). MCC reveals a trilinear differentiation characterized by neuroendocrine, epithelial and pre/pro B-cell lymphocytic gene expression disguising the cellular origin of MCC. Here we investigated the expression of the neuroendocrine key regulators RE1 silencing transcription factor (REST), neurogenic differentiation 1 (NeuroD1) and the Achaete-scute homolog 1 (ASCL1) in MCC. Read More

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December 2018
4 Reads

Prevalence and risk factors of human polyomavirus infections in non-malignant tonsils and gargles: the SPLIT study.

J Gen Virol 2018 Dec 8;99(12):1686-1698. Epub 2018 Nov 8.

1​International Agency for Research on Cancer, 69372 Lyon Cedex 08, France.

The prevalence of 13 polyomaviruses (PyVs) in the tonsil brushings and gargles of immunocompetent children and adults was assessed. Patients undergoing tonsillectomy for benign indications were recruited in 19 centres in France. After resection, the entire outer surface of the right and left halves of the tonsils was brushed extensively. Read More

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December 2018
11 Reads

Cohort Study of Albumin versus Lactated Ringer's for Postoperative Cardiac Surgery Fluid Resuscitation in the Intensive Care Unit.

Pharmacotherapy 2018 Dec;38(12):1241-1249

Anesthesiology & Perioperative Medicine, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon.

Purpose: A new postcardiac surgery fluid resuscitation strategy was implemented in our cardiovascular intensive care unit (CVICU) to implement evidence-based practice. We transitioned from a primarily albumin fluid-based strategy to a lactated Ringer's fluid-based strategy. We sought to determine whether a new postoperative fluid resuscitation strategy significantly altered the fluid composition for postcardiac surgery patients and what effect that would have on fluid resuscitation costs. Read More

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December 2018
1 Read

Pharmacological inhibition of serine palmitoyl transferase and sphingosine kinase-1/-2 inhibits Merkel Cell Carcinoma cell proliferation.

J Invest Dermatol 2018 Nov 3. Epub 2018 Nov 3.

Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria; Center for Explorative Lipidomics, BioTechMed-Graz, Graz, Austria. Electronic address:

The majority of Merkel cell carcinoma (MCC), a highly aggressive neuroendocrine cancer of the skin, is associated with Merkel cell polyomavirus (MCPyV) infection. Polyomavirus binding, internalization and infection is mediated by glycosphingolipids (GSL). Besides receptor function, bioactive sphingolipids (SL) are increasingly recognized as potent regulators of several hallmarks of cancer. Read More

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November 2018
4 Reads

Expression of novel proteins by polyomaviruses and recent advances in the structural and functional features of agnoprotein of JC virus, BK virus, and simian virus 40.

J Cell Physiol 2018 Nov 2. Epub 2018 Nov 2.

Laboratory of Molecular Neurovirology, Department of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Polyomavirus family consists of a highly diverse group of small DNA viruses. The founding family member (MPyV) was first discovered in the newborn mouse in the late 1950s, which induces solid tumors in a wide variety of tissue types that are the epithelial and mesenchymal origin. Later, other family members were also isolated from a number of mammalian, avian and fish species. Read More

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November 2018
6 Reads

Hepatic growth hormone - JAK2 - STAT5 signalling: Metabolic function, non-alcoholic fatty liver disease and hepatocellular carcinoma progression.

Cytokine 2018 Oct 30. Epub 2018 Oct 30.

Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria; Medical University of Vienna, Vienna, Austria. Electronic address:

The rising prevalence of obesity came along with an increase in associated metabolic disorders in Western countries. Non-alcoholic fatty liver disease (NAFLD) represents the hepatic manifestation of the metabolic syndrome and is linked to primary stages of liver cancer development. Growth hormone (GH) regulates various vital processes such as energy supply and cellular regeneration. Read More

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October 2018
1 Read

Infection and coinfection by human papillomavirus, Epstein-Barr virus and Merkel cell polyomavirus in patients with squamous cell carcinoma of the larynx: a retrospective study.

PeerJ 2018 24;6:e5834. Epub 2018 Oct 24.

Laboratorio de Inmunología y Virología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.

Background: Human papillomavirus (HPV) is recognized as an important risk factor for laryngeal carcinogenesis. Although HPV-16 and 18 have been strongly implicated, the presence of other high-risk HPV (HR-HPV) genotypes or the coinfection with Epstein-Barr virus (EBV) or Merkel cell polyomavirus (MCPV) may increase the risk, but their etiological association has not been definitively established.

Methods: We characterized the genotype-specific HPV and the frequency of EBV and MCPV infections through the detection of their DNA in 195 laryngeal specimens of squamous cell carcinoma (SCC) histologically confirmed. Read More

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October 2018
1 Read