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    INSM1: A Novel Nuclear Marker in Merkel Cell Carcinoma (Cutaneous Neuroendocrine Carcinoma).
    J Cutan Pathol 2017 Nov 17. Epub 2017 Nov 17.
    Department of Pathology & Laboratory Medicine, University of Wisconsin Hospital and Clinics, United States.
    Merkel cell carcinoma (MCC) is a rare, clinically aggressive, cutaneous neuroendocrine (NE) neoplasm. As a tumor with small, round, blue cells, the histologic differential diagnosis for MCC can include melanoma, metastatic small cell carcinoma (SCC), nodular hematopoietic tumors, basal cell carcinoma (BCC), atypical variants of squamous carcinoma, and the uncommon occurrence of primary cutaneous Ewing sarcoma. In cases with atypical histology or without the classic immunophenotype the diagnosis can be challenging. Read More

    A rare case of Merkel cell carcinoma presenting as a giant intra-thoracic mass: A case report and review of the literature.
    Medicine (Baltimore) 2017 Nov;96(46):e8743
    aDepartment of General Surgery, Xuzhou Infectious Disease Hospital bDepartment of Thoracic Surgery cDepartment of Respiratory Medicine, Xuzhou Central Hospital Affiliated to Southeast University, Xuzhou, China.
    Rationale: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine-derived cutaneous cancer. Ectopic or single metastatic MCC located in thorax is extremely rare; meanwhile, its definite management has not been elucidated yet.

    Patient Concerns: A 64-year-old female patient with a giant mass located in her left thorax was presented for stuffy pain of left chest for 6 months and fever for half a month. Read More

    Interaction between Merkel cell carcinoma and the immune system: Pathogenetic and therapeutic implications.
    Mol Clin Oncol 2017 Nov 1;7(5):729-732. Epub 2017 Sep 1.
    Unit of Dermatology, University of Padua, I-35128 Padua, Italy.
    Merkel cell carcinoma (MCC) is a rare, aggressive primary cutaneous neuroendocrine carcinoma. It usually appears on the face and neck of elderly Caucasian people as a flesh-colored, erythematous or violaceous dome-shaped, non-tender nodule with a smooth surface. In immunocompromised patients with T-cell dysfunction, such as patients with acquired immunodeficiency syndrome (AIDS) or solid organ transplant recipients, the incidence of this disease is markedly increased. Read More

    Immune evasion mechanisms and immune checkpoint inhibition in advanced merkel cell carcinoma.
    Oncoimmunology 2017 31;6(10):e1338237. Epub 2017 Aug 31.
    Department of Surgery and Medicine, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
    Merkel cell carcinoma (MCC) is a rare skin cancer caused by Merkel cell polyomavirus (MCPyV) infection and/or ultraviolet radiation-induced somatic mutations. The presence of tumor-infiltrating lymphocytes is evidence that an active immune response to MCPyV and tumor-associated neoantigens occurs in some patients. However, inhibitory immune molecules, including programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1), within the MCC tumor microenvironment aid in tumor evasion of T-cell-mediated clearance. Read More

    Evaluation of real-world treatment outcomes in patients with distant metastatic Merkel cell carcinoma following second-line chemotherapy in Europe.
    Oncotarget 2017 Oct 13;8(45):79731-79741. Epub 2017 Jul 13.
    Merck KGaA, 64293 Darmstadt, Germany.
    Background And Aims: Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer; few treatments exist for patients with advanced disease. Once tumors metastasize to distant sites, patients generally receive chemotherapy, but response duration and progression-free survival (PFS) are typically short. Few studies have assessed the efficacy of second-line chemotherapy for metastatic MCC. Read More

    Anti-PD-L1/TGFβR2 (M7824) fusion protein induces immunogenic modulation of human urothelial carcinoma cell lines, rendering them more susceptible to immune-mediated recognition and lysis.
    Urol Oncol 2017 Nov 2. Epub 2017 Nov 2.
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD. Electronic address:
    Background: Avelumab has recently been approved by the Food and Drug Administration for the therapy of Merkel cell carcinoma and urothelial carcinoma. M7824 is a novel first-in-class bifunctional fusion protein comprising a monoclonal antibody against programmed death-ligand 1 (PD-L1, avelumab), fused to the extracellular domain of human transforming growth factor beta (TGFβ) receptor 2, which functions as a TGFβ "trap." Advanced urothelial tumors have been shown to express TGFβ, which possesses immunosuppressive properties that promote cancer progression and metastasis. Read More

    A pilot study of Merkel cell polyomavirus in squamous cell carcinoma of the tongue.
    Oral Oncol 2017 Nov 4;74:111-114. Epub 2017 Oct 4.
    Department of Otolaryngology - Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, USA; Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA, USA; Department of Surgery, Overton Brooks Veterans Affairs Hospital, Shreveport, LA, USA. Electronic address:

    Merkel Cell Carcinoma: Current United States Incidence and Projected Increases based on Changing Demographics.
    J Am Acad Dermatol 2017 Nov 1. Epub 2017 Nov 1.
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Divisions of Medical Oncology and Dermatology, Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address:
    Background: Merkel cell carcinoma (MCC) incidence rates are rising and strongly age-associated, relevant for an aging population.

    Objective: Determine MCC incidence in the United States and project incident cases through the year 2025.

    Methods: Registry data were obtained from the SEER-18 database, containing 6,600 MCC cases. Read More

    Merkel cell polyomavirus small T antigen drives cell motility via Rho-GTPase-induced filopodia formation.
    J Virol 2017 Nov 1. Epub 2017 Nov 1.
    School of Molecular and Cellular Biology, Faculty of Biological Sciences, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, School of Veterinary Medicine, School of Biosciences and Medicine, University of Surrey, Surrey, United Kingdom
    Cell motility and migration is a complex, multi-step, and multi-component process, intrinsic to progression and metastasis. Motility is dependent on the activity of integrin receptors and Rho-family GTPases resulting in the remodelling of the actin cytoskeleton and formation of various motile actin-based protrusions. Merkel cell carcinoma (MCC) is an aggressive skin cancer with a high likelihood of recurrence and metastasis. Read More

    Analyses of functions of an anti-PD-L1/TGFβR2 bispecific fusion protein (M7824).
    Oncotarget 2017 Sep 8;8(43):75217-75231. Epub 2017 Sep 8.
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
    M7824 (MSB0011359C) is a novel first-in-class bifunctional fusion protein consisting of a fully human IgG1 anti-PD-L1 monoclonal antibody (with structural similarities to avelumab) linked to the extracellular domain of two TGFβ receptor 2 (TGFβR2) molecules serving as a TGFβ Trap. Avelumab has demonstrated clinical activity in a range of human cancers and has been approved by the Food and Drug Administration for the therapy of Merkel cell and bladder carcinomas. Preclinical studies have shown this anti-PD-L1 is capable of mediating antibody-dependent cell-mediated cytotoxicity (ADCC). Read More

    Dermoscopic assessment of vascular structures in solitary small pink lesions-differentiating between good and evil.
    Dermatol Pract Concept 2017 Jul 31;7(3):47-50. Epub 2017 Jul 31.
    Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA.
    The diagnosis of a single small pink papule poses a real challenge to the clinician, as the differential diagnosis of such lesions includes benign entities such as a neurofibroma or hemangioma, as well as aggressive and potentially fatal skin malignancies such as amelanotic melanoma or Merkel cell carcinoma (MCC). The absence of a benign vascular pattern and the presence of atypical vascular features under dermoscopy direct the clinician to proceed to histologic evaluation in order to rule out a malignant process in such lesions. The diagnosis of MCC is particularly problematic, given that this tumor usually lacks specific clinical diagnostic features. Read More

    Genetic Profiles of Different Subsets of Merkel Cell Carcinoma Show Links between Combined and Pure MCPyV-negative Tumors.
    Hum Pathol 2017 Oct 24. Epub 2017 Oct 24.
    Department of Pathology and Laboratory Medicine (DPLM), Queen Elizabeth II Health Sciences Centre, Nova Scotia Health Authority (Central Zone), Halifax, NS, B3H 1V8, Canada; Departments of Pathology and (c) Medicine, Dalhousie University, Halifax, NS, B3H 1V8, Canada.
    Tumorigenesis in Merkel cell carcinoma (MCC) is driven by (i) clonal integration of the Merkel cell polyomavirus (MCPyV) in neoplastic cells and/or (ii) genetic damage by ultraviolet (UV) light. A higher mutational burden, a UV-mutational signature, and many mutations in the TP53 and RB1 genes characterize the virus-negative subset. MCPyV-negative MCCs include combined (often squamous and neuroendocrine) and pure (neuroendocrine) tumors. Read More

    Histologic Mimics of Basal Cell Carcinoma.
    Arch Pathol Lab Med 2017 Nov;141(11):1490-1502
    From the Departments of Pathology (Drs Stanoszek, Wang, and Harms) and Dermatology (Dr Harms), University of Michigan Medical School, Ann Arbor. Drs Stanoszek and Wang contributed equally.
    Context: - Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Read More

    Merkel cell carcinoma.
    Nat Rev Dis Primers 2017 Oct 26;3:17077. Epub 2017 Oct 26.
    Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington, USA.
    Merkel cell carcinoma (MCC) is a rare but highly aggressive skin cancer with neuroendocrine features. MCC pathogenesis is associated with either the presence of Merkel cell polyomavirus or chronic exposure to ultraviolet light (UV), which can cause a characteristic pattern of multiple DNA mutations. Notably, in the Northern hemisphere, the majority of MCC cases are of viral aetiology; by contrast, in areas with high UV exposure, UV-mediated carcinogenesis is predominant. Read More

    Iatrogenic solid tumors following immunosuppressive therapy.
    Semin Diagn Pathol 2017 Sep 20. Epub 2017 Sep 20.
    Department of Pathology, Presbyterian Shadyside Hospitals, University of Pittsburgh Medical Center, 5230 Centre Avenue Pittsburgh, PA 15232, United States. Electronic address:
    Immunosuppression induced by chronic medication, such as occurs post-transplantation, may increase a patient's risk of developing solid tumors. These are often rare tumors characterized by odd presentations. This review focuses on commonly encountered iatrogenic, non-hematopoietic solid tumors following immunotherapy and provides a practical approach to their diagnosis. Read More

    Merkel cell carcinoma with fingolimod treatment for multiple sclerosis: A case report.
    Mult Scler Relat Disord 2017 Oct 22;17:12-14. Epub 2017 Jun 22.
    Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland, OH, USA.
    Neoplasms and reactivation of latent viruses have been observed in individuals taking fingolimod. Merkel cell carcinoma (MCC), a rare neuroendocrine skin cancer, is associated with immunosuppression and can be triggered by the oncogenic Merkel cell polyoma virus (MCPyV). We report a case of a 61-year-old man with multiple sclerosis who developed MCPyV-positive MCC 4 years after starting fingolimod. Read More

    Merkel Cell Polyomavirus: A New DNA Virus Associated with Human Cancer.
    Adv Exp Med Biol 2017 ;1018:35-56
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
    Merkel cell polyomavirus (MCPyV or MCV) is a novel human polyomavirus that has been discovered in Merkel cell carcinoma (MCC), a highly aggressive skin cancer. MCPyV infection is widespread in the general population. MCPyV-associated MCC is one of the most aggressive skin cancers, killing more patients than other well-known cancers such as cutaneous T-cell lymphoma and chronic myelogenous leukemia (CML). Read More

    Discovery and Characterization of Novel Trans-Spliced Products of Human Polyoma JC Virus Late Transcripts from PML Patients.
    J Cell Physiol 2017 Oct 16. Epub 2017 Oct 16.
    Department of Neuroscience, Laboratory of Molecular Neurovirology, MERB-757, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia PA 19140.
    Although the human neurotropic polyomavirus, JC virus (JCV), was isolated almost a half century ago, understanding the molecular mechanisms governing its biology remains highly elusive. JCV infects oligodendrocytes and astrocytes in the central nervous system (CNS) and causes a fatal brain disease known as progressive multifocal leukoencephalopathy (PML) in immunocompromised individuals including AIDS. It has a small circular DNA genome (∼ 5 kb) and generates two primary transcripts from its early and late coding regions, producing several predicted alternatively spliced products mainly by cis-splicing. Read More

    Inherited and acquired clinical phenotypes associated with neuroendocrine tumors.
    Curr Opin Allergy Clin Immunol 2017 Dec;17(6):431-442
    aDepartment of Pediatrics bDepartment of Internal Medicine, Division of Allergy and Immunology cChildren's Health, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
    Purpose Of Review: Overview of neuroendocrine neoplasms in the context of their associations with primary and secondary immunodeficiency states.

    Recent Findings: Malignancies of neuroendocrine origin are well known to be associated with hereditary syndromes, including multiple endocrine neoplasia type 1, von Hippel-Lindau syndrome, neurofibromatosis type 1, and tuberous sclerosis. This review includes the X-linked form of hyper-IgM syndrome (XHIGM), due to mutations in the CD40Ligand gene (CD40LG), as an additional inherited disorder with susceptibility to such malignancies, and discusses neuroendocrine tumors (NETs) arising in other immunocompromised states. Read More

    Is this the end of cytotoxic chemotherapy in Merkel cell carcinoma?
    Onco Targets Ther 2017 28;10:4803-4807. Epub 2017 Sep 28.
    Department of Medical Oncology, Center for Head and Neck Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
    Although cytotoxic chemotherapy has been used often in the management of Merkel cell carcinoma (MCC), its benefit remains uncertain. Despite being considered a chemosensitive disease, the duration of response is generally short, and the survival benefit is unclear. With the recent FDA approval of the anti-programmed cell death ligand 1 (PD-L1) antibody avelumab for patients with advanced MCC and the limited and controversial data on chemotherapy, it is important to put in perspective whether conventional chemotherapy should remain an option for these patients. Read More

    Definitive radiotherapy for a head and neck Merkel cell carcinoma and comprehensive nodal volumes: a case for using a computer-designed variable-thickness compensator to reduce risk and severity of mucositis.
    Med Dosim 2017 Oct 11. Epub 2017 Oct 11.
    21st Century Oncology, Department of Radiation Oncology, Fort Lauderdale, FL.
    When contemplating how to treat head and neck primary cancers and regional lymph nodes with radiotherapy, we often select the contemporary intensity-modulated radiotherapy (IMRT) without much consideration of older methods that may give fewer side effects and be more cost-effective. For an 87-year-old female with a 1.5-cm Merkel cell carcinoma (MCC) located 1. Read More

    Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis.
    PLoS Pathog 2017 Oct 13;13(10):e1006668. Epub 2017 Oct 13.
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.
    Merkel cell carcinoma (MCC) frequently contains integrated copies of Merkel cell polyomavirus DNA that express a truncated form of Large T antigen (LT) and an intact Small T antigen (ST). While LT binds RB and inactivates its tumor suppressor function, it is less clear how ST contributes to MCC tumorigenesis. Here we show that ST binds specifically to the MYC homolog MYCL (L-MYC) and recruits it to the 15-component EP400 histone acetyltransferase and chromatin remodeling complex. Read More

    Isolated Limb Infusion: A Single-Center Experience with Over 200 Infusions.
    Ann Surg Oncol 2017 Dec 10;24(13):3842-3849. Epub 2017 Oct 10.
    Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, USA.
    Background: Isolated limb infusion (ILI) is a minimally invasive technique for delivering regional chemotherapy to an extremity for patients with locally advanced cutaneous malignancies and sarcoma.

    Methods: A single-institution, prospectively collected database was analyzed for intention-to-treat with ILI.

    Results: From 2007 to 2016, 163 patients underwent 205 procedures (201 were successfully completed), and four malignancies were treated: melanoma (72. Read More

    Merkel cell carcinoma in a patient with relapsing-remitting multiple sclerosis treated with fingolimod.
    J Neurol Sci 2017 Oct 5;381:296-297. Epub 2017 Sep 5.
    Neurodegenerative Diseases Unit, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

    Merkel Cell Carcinoma of the Buccal Mucosa and Lower Lip.
    Head Neck Pathol 2017 Oct 4. Epub 2017 Oct 4.
    Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL, 32610, USA.
    Merkel cell carcinoma (MCC) is an uncommon relatively aggressive neuroendocrine dermal neoplasm first described in 1972 as a tumor of the sun exposed skin. Although most MCC affect the skin of the head and neck, rare primarily oral mucosal cases have been documented. Merkel cells are nondendritic neuroendocrine cells that are found not only in the skin but also the oral mucosa and give rise to MCC. Read More

    Avelumab and other recent advances in Merkel-cell carcinoma.
    Future Oncol 2017 Oct 4. Epub 2017 Oct 4.
    Departments of Surgery & Medicine, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA.
    Merkel-cell carcinoma (MCC) is a rare but aggressive form of skin cancer that occurs in the elderly, is associated with UV radiation and immunosuppression. Initial treatment consists of wide excision with adjuvant radiation. Although the tumor is sensitive to chemotherapy, long-term survival is unusual and there had been no US FDA-approved drugs prior to 2017. Read More

    Primary Merkel Cell Carcinoma on the Cheek: Three Case Reports.
    J Coll Physicians Surg Pak 2017 Sep;27(9):S122-S124
    Department of Urinary Surgery, Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, 028007, The Inner Mongolia Autonomous Region, China.
    Merkel cell carcinoma (MCC) is a rare aggressive cutaneous neuroendocrine carcinoma that typically arises in sunexposed areas of the skin. Herein, we present three cases of primary MCC of the cheek. Case 1 had multiple nodules and mild swelling on the left cheek and eyelids, the patient did not receive any treatment and died after 10 months. Read More

    Understanding the influence of patient demographics on disease severity, treatment strategy, and survival outcomes in merkel cell carcinoma: a surveillance, epidemiology, and end-results study.
    Oncoscience 2017 Jul 14;4(7-8):106-114. Epub 2017 Sep 14.
    University of Rome Tor Vergata, Department of Dermatology, Rome, Italy.
    Objective: To identify trends in patient presentation and outcomes data that may guide the development of clinical algorithms on Merkel Cell Carcinoma (MCC).

    Methods: We performed a retrospective cohort study searching in the National Cancer Institute's SEER registry for documented MCC cases from 1986-2013. No exclusion criteria were applied. Read More

    Aggressive Merkel cell carcinoma in a liver transplant recipient.
    Cutis 2017 Aug;100(2):103;104;124
    Department of Dermatology, Mount Sinai Beth Israel Hospital, New York, New York, USA.
    Merkel cell carcinoma (MCC) is a rare aggressive cutaneous tumor that commonly occurs in sun-exposed sites. It has a tendency for rapid growth, local recurrence, lymph node invasion, and distant metastases. Risk factors include immunosuppression, advanced age, exposure to UV radiation, and infection with the Merkel cell polyomavirus. Read More

    Low viral load of Merkel cell polyomavirus in Iranian patients with head and neck squamous cell carcinoma: Is it clinically important?
    J Med Virol 2017 Sep 28. Epub 2017 Sep 28.
    Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.
    Recent studies show that the human Merkel cell polyomavirus (MCPyV) may be involved in causing cancer. The objective of this study was to assess the impact of MCPyV on the development of head and neck squamous cell carcinoma (HNSCC). In total, 50 paraffin-embedded HNSCC biopsy samples and 50 adjacent non-cancerous samples were evaluated for the presence of MCPyV DNA and RNA. Read More

    Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas.
    Yonago Acta Med 2017 Sep 15;60(3):145-153. Epub 2017 Sep 15.
    §Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine, Yonago 683-8503, Japan.
    Background: Merkel cell carcinomas (MCCs), clinically aggressive neuroendocrine skin cancers, are divided into Merkel cell polyomavirus (MCPyV)-positive and -negative tumors, which show different clinicopathological features and may develop through different mechanisms of carcinogenesis. Aberrant expression of activation-induced cytidine deaminase (AID) as a genomic modulator was demonstrated through pathogen-related NF-κB signal in Helicobacter pylori-associated gastric cancer, adult T cell leukemia/lymphoma (HTLV-1), hepatoma (HCV), and Burkitt lymphoma (EBV).

    Methods: To elucidate the relation of aberrant AID expression in MCPyV-positive and -negative MCCs, we evaluated immunohistochemical expressions of AID and AID-regulating factors between 24 MCPyV-positive and 17 MCPyV-negative MCCs. Read More

    Merkel cell carcinoma cardiac metastasis causing cardiac tamponade.
    BMJ Case Rep 2017 Sep 25;2017. Epub 2017 Sep 25.
    Nuclear Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
    We describe an unusual presentation of Merkel cell carcinoma (MCC), a rare neuroendocrine cutaneous tumour. A 59-year-old man presented with a 2-week history of dyspnoea on a background of MCC of the left elbow that was diagnosed after an axillary lymph node metastasis had appeared. He was clinically diagnosed with cardiac tamponade and received urgent pericardiocentesis. Read More

    [Lymph node metastasis of Merkel cell carcinoma without known cutaneous primary - case report].
    Cesk Patol 2017 ;53(3):135-138
    Merkel cell carcinoma is a rare cutaneous tumor with an aggressive clinical course. In most cases it is associated with Merkel cell polyomavirus infection. Exceptionally, the tumor can present as a lymph node metastasis without a discernible cutaneous primary. Read More

    Sentinel lymph node biopsy in periocular merkel cell carcinoma: a case report.
    BMC Res Notes 2017 Sep 20;10(1):490. Epub 2017 Sep 20.
    University of Arizona COM Phoenix, University of Arizona Cancer Center at Dignity Health, 625 N 6th Street, Phoenix, AZ, 85004, USA.
    Background: The National Comprehensive Cancer Network guidelines for Merkel cell carcinoma recommend performance of the sentinel lymph node biopsy in all patients with clinically negative nodal disease for staging and treatment. Nevertheless, sentinel lymph node biopsy in the periocular region is debated as tumors are typically smaller and lymphatic variability can make performance procedurally problematic.

    Case Presentation: We present a case of a Caucasian patient in their seventies who presented with a 1. Read More

    T cell therapies for human polyomavirus diseases.
    Cytotherapy 2017 Sep 15. Epub 2017 Sep 15.
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA; Columbia Center for Translational Immunology, Division of Hematology and Oncology, Columbia University Medical Center, New York, NY, USA. Electronic address:
    Rapid restoration of virus-specific T immunity via adoptive transfer of ex vivo generated T cells has been proven as a powerful therapy for patients with advanced cancers and refractory viral infections such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV). BK virus (BKV), John Cunningham virus (JCV), and Merkel cell carcinoma virus (MCV) are the members of the rapidly growing human polyomavirus (hPyV) family that commonly infects most healthy humans. These viruses have a clearly established potential for causing severe end-organ damage or malignant transformation, especially in individuals with weakened immunity who are unable to mount or regain endogenous T-cell responses as a result of underlying leukemia or iatrogenic immunosuppression in autoimmunity, bone marrow and solid organ transplant settings. Read More

    Merkel cell carcinoma: Epidemiology, pathogenesis, diagnosis and therapy.
    Rev Endocr Metab Disord 2017 Sep 16. Epub 2017 Sep 16.
    Center for Dermatooncology, Department of Dermatology, University Hospital Tuebingen, Liebermeisterstr. 25, 72076, Tuebingen, Germany.
    Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with a neuroendocrine phenotype. Incidence varies according to the geographic regions but is overall increasing. Different risk factors have been identified namely advanced age, immunosuppression, and ultraviolet light exposure. Read More

    [Teledermoscopy by mobile phones : Reliable help in the diagnosis of skin lesions?]
    Hautarzt 2017 Nov;68(11):890-895
    Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Klinikum rechts der Isar, Technische Universität München, Biedersteiner Str. 29, 80802, München, Deutschland.
    Background: Teledermoscopy is a promising modern technique to complement or to substitute dermatologic examination.

    Objective: In this pilot study, we compared the outcomes of teledermoscopic consultations with clinical examinations and histologic results.

    Methods: Conventional and dermatoscopic photos of single lesions were taken in 26 patients using a mobile phone and an attached handyscope optical system. Read More

    Anaplastic Lymphoma Kinase in Cutaneous Malignancies.
    Cancers (Basel) 2017 Sep 12;9(9). Epub 2017 Sep 12.
    Harvard Medical School, Boston, MA 02115, USA.
    Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that has been implicated in the pathogenesis of a variety of neoplasms. As suggested by its name, ALK was first described as part of a translocation product in cases of anaplastic large-cell lymphoma, with other genetic and cytogenetic ALK mutations subsequently coming to attention in the development of many other hematologic and solid organ malignancies. ALK has now been shown to play a role in the pathogenesis of several cutaneous malignancies, including secondary cutaneous systemic anaplastic large-cell lymphoma (ALCL) and primary cutaneous ALCL, melanoma, spitzoid tumors, epithelioid fibrous histiocytoma, Merkel cell carcinoma, and basal cell carcinoma. Read More

    Merkel cell polyomavirus and Merkel cell carcinoma.
    Philos Trans R Soc Lond B Biol Sci 2017 Oct;372(1732)
    Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA
    Merkel cell polyomavirus (MCPyV) causes the highly aggressive and relatively rare skin cancer known as Merkel cell carcinoma (MCC). MCPyV also causes a lifelong yet relatively innocuous infection and is one of 14 distinct human polyomaviruses species. Although polyomaviruses typically do not cause illness in healthy individuals, several can cause catastrophic diseases in immunocompromised hosts. Read More

    Tumour virology in the era of high-throughput genomics.
    Philos Trans R Soc Lond B Biol Sci 2017 Oct;372(1732)
    Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 9A, 405 30 Gothenburg, Sweden
    With the advent of massively parallel sequencing, oncogenic viruses in tumours can now be detected in an unbiased and comprehensive manner. Additionally, new viruses or strains can be discovered based on sequence similarity with known viruses. Using this approach, the causative agent for Merkel cell carcinoma was identified. Read More

    Treatment of Metastatic Eyelid Carcinoma.
    J Craniofac Surg 2017 Nov;28(8):e722-e725
    *Head and Neck Departement, University of Naples Federico II, Naples †Neurosurgery Departement, University of Salerno, Salerno, Italy.
    Purpose: The aim of this study was to report management and outcomes in patients affected by eyelids carcinomas involving regional lymph nodes.

    Methods: We have retrospectively analyzed the data of patients affected by eyelids carcinoma with nodal involvement. The clinical records of 10 patients with malignant eyelid carcinoma and regional nodal metastasis treated between September 2011 and March 2015 have been analyzed. Read More

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