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    Merkel cell polyomavirus small T antigen initiates Merkel cell carcinoma-like tumor development in mice.
    Cancer Res 2017 May 16. Epub 2017 May 16.
    Department of Dermatology, Univ of Michigan Cancer Center
    Merkel cell carcinoma (MCC) tumor cells express several markers detected in normal Merkel cells, a non-proliferative population of neuroendocrine cells which arise from epidermis. MCCs frequently contain Merkel cell polyomavirus (MCPyV) DNA and express viral transforming antigens, sT and tLT, but the role of these putative oncogenes in MCC development, and this tumor's cell of origin, are unknown. Using a panel of pre-term transgenic mice, we show that epidermis-targeted co-expression of sT and the cell fate determinant atonal bHLH transcription factor 1 (Atoh1) leads to development of widespread cellular aggregates with histology and marker expression mimicking that of human intraepidermal MCC. Read More

    Comparison of the incidence of skin cancers in patients on dialysis and after kidney transplantation.
    Postepy Dermatol Alergol 2017 Apr 13;34(2):138-142. Epub 2017 Apr 13.
    Department of Nephrology, Jagiellonian University Medical College, Krakow, Poland.
    Introduction: Kidney transplant (KTx) patients on immunosuppressive therapy are predisposed to the development of infections and cancers.

    Aim: To compare the incidence and type of malignant skin lesions in kidney transplant patients and the dialyzed population based on the initiated dermatologic screening.

    Material And Methods: The study included 598 patients: 486 kidney transplant recipients and 112 patients on maintenance dialysis. Read More

    Merkel cell carcinoma: morphologic aspects on reflectance confocal microscopy.
    J Eur Acad Dermatol Venereol 2017 May 14. Epub 2017 May 14.
    Dermatology department, University of Modena and Reggio Emilia, Italy.
    Merkel cell carcinoma (MCC) is an uncommon skin tumour with aggressive behaviour. Clinically, MCC usually appear as a fast growing red cherry nodule on the leg or face of elderly patients (1-4). Dermoscopically, it might reveal a reddish background with arborizing not in focus vessels, a pattern that is rather aspecific. Read More

    Definitive radiotherapy for Merkel cell carcinoma confers clinically meaningful in-field locoregional control: A review and analysis of the literature.
    J Am Acad Dermatol 2017 May 8. Epub 2017 May 8.
    Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney, Australia; University of Sydney, Sydney, Australia; Department of Radiation Oncology, Westmead Hospital, Sydney, Australia. Electronic address:
    Background: Merkel cell carcinoma (MCC) is an uncommon radiosensitive, neuroendocrine malignancy. Treatment often involves surgery; however, older, sicker patients may not be candidates for an operation. Institutions have published data favoring the role of definitive radiotherapy for macroscopic locoregional disease. Read More

    Virus-Induced Cancers of the Skin and Mucosa: Are We Dealing with "Smoking Guns" or "Smoke and Mirrors" in the Operating Theatre?
    Dermatol Ther (Heidelb) 2017 May 8. Epub 2017 May 8.
    Department of Otorhinolaryngology and Head and Neck Surgery, Bielefeld University Hospital, Teutoburger Strasse 50, 33604, Bielefeld, Germany.
    Introduction: Human papillomavirus (HPV) alone is thought to cause ~610,000 cases of cancer per year, and is the dominant aetiological agent for ano-genital (esp. cervical) and head and neck cancers (esp. oropharyngeal). Read More

    Merkel Cell Carcinoma.
    Surg Pathol Clin 2017 Jun 14;10(2):399-408. Epub 2017 Mar 14.
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. Electronic address:
    Merkel cell carcinoma (MCC) encompasses neuroendocrine carcinomas primary to skin and occurs most commonly in association with clonally integrated Merkel cell polyomavirus with related retinoblastoma protein sequestration or in association with UV radiation-induced alterations involving the TP53 gene and mutations, heterozygous deletion, and hypermethylation of the Retinoblastoma gene. Molecular genetic signatures may provide therapeutic guidance. Morphologic features, although patterned, are associated with predictable diagnostic pitfalls, usually resolvable by immunohistochemistry. Read More

    Phospho-STAT5B Expression Is a Prognostic Marker for Merkel Cell Carcinoma.
    Anticancer Res 2017 05;37(5):2335-2341
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Background/aim: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma. Although recent reports suggest that tumor-infiltrating leukocytes (TILs), especially CD8(+) T-cells, contribute to the pathogenesis of MCC, it is difficult for a single Institute with a small number of patients with MCC to determine the threshold number of CD8(+) cells. Therefore, clearer and easier methods of evaluating prognostic factors of MCC are needed. Read More

    A Review of the Global Guidelines on Surgical Margins for Nonmelanoma Skin Cancers.
    J Clin Aesthet Dermatol 2017 Apr;10(4):37-46
    Ohio State University Wexner Medical Center, Columbus, Ohio.
    Background: Adequate treatment and follow-up of a patient with nonmelanoma skin cancer is of utmost concern for a clinician. However, there is a lack of international consensus on recommendations for surgical excision margins. Furthermore, lack of familiarity of the published guidelines leads to a variety in practice styles. Read More

    Avelumab: First Global Approval.
    Drugs 2017 May;77(8):929-937
    Springer, Private Bag 65901, Mairangi Bay 0754, Auckland, New Zealand.
    Avelumab (Bavencio(®)) is an intravenously administered programmed cell death ligand-1-blocking human antibody initially developed by EMD Serono Inc. (the biopharmaceutical division of Merck KGaA, Darmstadt, Germany) [now jointly developed and commercialized by EMD Serono Inc. and Pfizer] for the treatment of various tumours. Read More

    Evaluation of Merkel cell polyomavirus in non-small cell lung cancer and adjacent normal cells.
    Microb Pathog 2017 Apr 25;108:21-26. Epub 2017 Apr 25.
    Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran; Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran.
    Several risk factors have been linked to lung cancer (LC). Nevertheless, a viral etiology has been mentioned for a subset of patients developing LC. The aim of this study was to evaluate the effect of Merkel cell polyomavirus (MCPyV) on developing non-small cell lung cancer (NSCLCs). Read More

    The PP4R1 sub-unit of protein phosphatase PP4 is essential for inhibition of NF-κB by merkel polyomavirus small tumour antigen.
    Oncotarget 2017 Apr;8(15):25418-25432
    School of Molecular and Cellular Biology, Faculty of Biological Sciences, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.
    Merkel cell carcinoma (MCC) is a highly aggressive skin cancer with a high metastatic potential. The majority of MCC cases are caused by the Merkel cell polyomavirus (MCPyV), through expression of the virus-encoded tumour antigens. Whilst mechanisms attributing tumour antigen expression to transformation are being uncovered, little is known of the mechanisms by which MCPyV persists in the host. Read More

    Avelumab Impresses in Merkel Cell Carcinoma.
    • Authors:
    Cancer Discov 2017 Apr 24. Epub 2017 Apr 24.
    The PD-L1 inhibitor avelumab-approved by the FDA in March for the treatment of Merkel cell carcinoma-demonstrated a high number of durable responses in an international, open-label, prospective phase II study. The results of the study, which supported the FDA's decision, were presented in April at the American Association for Cancer Research (AACR) Annual Meeting 2017. Read More

    RE: Adjuvant Radiation Therapy and Chemotherapy in Merkel Cell Carcinoma: Survival Analyses of 6908 Cases From the National Cancer Data Base.
    J Natl Cancer Inst 2017 Oct;109(10)
    Affiliations of authors: Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA (JAV, SB); Department of Medicine, Division of Dermatology, West Virginia University, Morgantown, WV (ERG); Department of Epidemiology, Epidemiology Data Center, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA (GKB).

    Non-melanoma skin cancer: new and future synthetic drug treatments.
    Expert Opin Pharmacother 2017 May 17;18(7):689-699. Epub 2017 Apr 17.
    a Center for Dermatooncology, Department of Dermatology , University Hospital Tübingen , Tübingen , Germany.
    Introduction: Non-melanoma skin cancers (NMSC) mainly comprise two different entities: basal cell carcinoma (BCC) and squamous cell carcinoma (SCC); beneath these two entities, Merkel cell carcinoma, adnexal tumors, dermatofibrosarcoma protuberans, angiosarcoma, and cutaneous lymphoma belong to NMSC. These rare skin tumors are not the topic of this review. BCC and SCC are the most common cancers diagnosed in humans. Read More

    Droplet digital PCR (ddPCR) vs quantitative real-time PCR (qPCR) approach for detection and quantification of Merkel cell polyomavirus (MCPyV) DNA in formalin fixed paraffin embedded (FFPE) cutaneous biopsies.
    J Virol Methods 2017 Apr 14;246:15-20. Epub 2017 Apr 14.
    Department of Experimental and Clinical Medicine, University of Florence, Italy. Electronic address:
    Background: Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma and high viral load in the skin was proposed as a risk factor for the occurrence of this tumour. MCPyV DNA was detected, with lower frequency, in different skin cancers but since the viral load was usually low, the real prevalence of viral DNA could be underestimated.

    Objective: To evaluate the performance of two assays (qPCR and ddPCR) for MCPyV detection and quantification in formalin fixed paraffin embedded (FFPE) tissue samples. Read More

    MGMT promoter methylation status in Merkel cell carcinoma: in vitro versus invivo.
    J Cancer Res Clin Oncol 2017 Apr 12. Epub 2017 Apr 12.
    Department of Translational Skin Cancer Research (tscr), University Hospital Essen, Universitätstraße 1, 45141, Essen, Germany.
    Purpose: Expression of O6-methylguanine-DNA methyltransferase (MGMT) in Merkel cell carcinoma (MCC) is very variable; thus, we tested whether this may be due to differential methylation of the MGMT gene promoter.

    Methods: Quantitative analysis of MGMT mRNA and protein expression, as well as MGMT promoter methylation status, was performed in a series of tissue samples of MCC tumors, representing both primary and metastatic lesions, as well as in six MCC cell lines.

    Results: These analyses revealed a very heterogeneous MGMT mRNA and protein expression in MCC both in vivo and in vitro. Read More

    Basal cell carcinoma: CD56 and cytokeratin 5/6 staining patterns in the differential diagnosis with Merkel cell carcinoma.
    J Cutan Pathol 2017 Jun;44(6):553-556
    Dermatopathology Division, Department of Dermatology, Yale School of Medicine, New Haven, Connecticut.
    Background: Basal cell carcinoma (BCC) can resemble Merkel cell carcinoma (MCC) on histopathological examination and while CK20 is a useful marker in this differential, it is occasionally negative in MCC. CD56, a sensitive marker of neuroendocrine differentiation, is sometimes used to identify MCC, but has been reportedly variably positive in BCC as well. In contrast, CK5/6 consistently labels BCC but is not expressed in neuroendocrine tumors. Read More

    Molecular Profiling of Multiple Primary Merkel Cell Carcinoma to Distinguish Genetically Distinct Tumors From Clonally Related Metastases.
    JAMA Dermatol 2017 Apr 12. Epub 2017 Apr 12.
    Department of Dermatology, University of Michigan Medical School, Ann Arbor3Michigan Center for Translational Pathology, University of Michigan, Ann Arbor4Department of Pathology, University of Michigan Medical School, Ann Arbor.
    Importance: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma. In rare cases, the development of an additional cutaneous MCC tumor is clinically consistent with a second primary MCC tumor rather than a cutaneous metastasis, which has important treatment and prognostic implications.

    Objective: To evaluate genetic relatedness in 4 cases with the clinical diagnosis of multiple primary MCCs. Read More

    What's New in Eyelid Tumors.
    Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):143-152
    Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, NY.
    Eyelid malignancies represent between 5% and 10% of all skin cancers. Basal cell carcinoma is the most common, followed by squamous cell carcinoma, sebaceous cell carcinoma, Merkel cell carcinoma, and melanoma. The gold standard treatment for periocular epithelial malignancies is surgical excision. Read More

    Spontaneous lung metastasis formation of human Merkel cell carcinoma cell lines transplanted into scid mice.
    Int J Cancer 2017 Jul 21;141(1):160-171. Epub 2017 Apr 21.
    Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Merkel cell carcinoma (MCC) is an aggressive skin cancer entity that frequently leads to rapid death due to its high propensity to metastasize. The etiology of most MCC cases is linked to Merkel cell polyomavirus (MCPyV), a virus which is monoclonally integrated in up to 95% of tumors. While there are presently no animal models to study the role of authentic MCPyV infection on transformation, tumorigenesis or metastasis formation, xenograft mouse models employing engrafted MCC-derived cell lines (MCCL) represent a promising approach to study certain aspects of MCC pathogenesis. Read More

    Avelumab for patients with previously treated metastatic or recurrent non-small-cell lung cancer (JAVELIN Solid Tumor): dose-expansion cohort of a multicentre, open-label, phase 1b trial.
    Lancet Oncol 2017 May 31;18(5):599-610. Epub 2017 Mar 31.
    University of California-Davis, Comprehensive Cancer Center, Sacramento, CA, USA.
    Background: Avelumab, a human Ig-G1 monoclonal antibody targeting PD-L1 and approved in the USA for the treatment of metastatic Merkel cell carcinoma, has shown antitumour activity and an acceptable safety profile in patients with advanced solid tumours in a dose-escalation phase 1a trial. In this dose-expansion cohort of that trial, we assess avelumab treatment in a cohort of patients with advanced, platinum-treated non-small-cell lung cancer (NSCLC).

    Methods: In this dose-expansion cohort of a multicentre, open-label, phase 1 study, patients with progressive or platinum-resistant metastatic or recurrent NSCLC were enrolled at 58 cancer treatment centres and academic hospitals in the USA. Read More

    Impact of total radiotherapy dose on survival for head and neck Merkel cell carcinoma after resection.
    Head Neck 2017 Mar 29. Epub 2017 Mar 29.
    Department of Radiation Oncology, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts.
    Background: Head and neck Merkel cell carcinoma (MCC) is commonly treated with surgery and adjuvant radiotherapy (RT) for high-risk features. The optimal radiation dose is unknown.

    Methods: One thousand six hundred twenty-five eligible patients with head and neck MCC were identified in the National Cancer Data Base (NCDB). Read More

    Erythema ab igne: new technology rebounding upon its users?
    Int J Dermatol 2017 Mar 30. Epub 2017 Mar 30.
    Dermatology and Pathology, Rutgers New Jersey Medical School, Rutgers University School of Public Affairs and Administration, Newark, NJ, USA.
    Erythema ab igne (EAI) is a persistent, chronic skin condition resulting from prolonged exposure to infrared radiation, experienced as heat. Once associated with traditional warming sources like wood burning stoves or open fires, modern, infrared exposure originates also from newer sources like laptops and heating pads and may be creating a rebound of EAI. The epidemiology may be different too, with younger patients than previously seen. Read More

    Aberrant expression of ALK and EZH2 in Merkel cell carcinoma.
    BMC Cancer 2017 Mar 31;17(1):236. Epub 2017 Mar 31.
    Department of Pathology, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, FI-00014, Helsinki, Finland.
    Background: Distinct characteristic features categorize Merkel cell carcinoma (MCC) into two subgroups according to the Merkel cell polyomavirus infection. Many mutational studies on MCC have been carried out in recent years without identifying a prominent driver mutation. However, there is paucity reporting the expression of cancer genes at the RNA level in MCC tumors. Read More

    Prognostic Value of the Staging System for Eyelid Tumors in the 7th Edition of the American Joint Committee on Cancer Staging Manual.
    Ophthal Plast Reconstr Surg 2017 Mar 27. Epub 2017 Mar 27.
    *Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, and †Department of Ophthalmology, Tulane University, New Orleans, Louisiana, U.S.A.
    Purpose: To determine the prognostic value of the staging criteria for eyelid tumors in the 7th edition of the American Joint Committee on Cancer (AJCC) staging manual and to determine, for each type of eyelid tumor, which AJCC T categories are associated with increased risk of nodal metastasis and thus potential usefulness of sentinel lymph node biopsy.

    Methods: Systematic review and analysis of articles found by searching PubMed and Google Scholar using the search terms "AJCC," "eyelid," "carcinoma," and "melanoma."

    Results: Rates of local recurrence, regional nodal metastasis, and distant metastasis were approximately 7% to 10%, 1% to 9%, and 0% to 0. Read More

    Systematic literature review of efficacy, safety and tolerability outcomes of chemotherapy regimens in patients with metastatic Merkel cell carcinoma.
    Future Oncol 2017 Mar 28. Epub 2017 Mar 28.
    Translational Skin Cancer Research, German Cancer Consortium (DKTK), Partner site Essen Düsseldorf, University Hospital Essen, Essen, Germany.
    Aim: Merkel cell carcinoma (MCC) is a rare neuroendocrine, cutaneous malignancy with poor prognosis once metastasized. The aim of this study was to conduct a systematic literature review to assess clinical outcomes associated with chemotherapy regimens in metastatic MCC.

    Materials & Methods: Embase(®), MEDLINE(®), MEDLINE(®)-In-Process and CENTRAL were searched for studies published in January 2016. Read More

    [Skin cancers in kidney transplant recipients].
    Wiad Lek 2017;70(1):68-73
    I Klinika Nefrologii I Transplantologii Z Ośrodkiem Dializ Uniwersytetu Medycznego, Białystok, Polska.
    Kidney transplantation is the best treatment for end-stage renal failure. It prolongs the patient's life, improves quality of life and reduces costs associated with renal replacement therapy. Increasingly, newer immunosuppressive regimens allow for the proper functioning of the transplanted organ for many years. Read More

    Seeking Standards for the Detection of Merkel Cell Polyomavirus and its Clinical Significance.
    J Invest Dermatol 2017 Apr;137(4):797-799
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Electronic address:
    Merkel cell carcinoma is a rare skin cancer associated with Merkel cell polyomavirus in most cases. Prior studies associating Merkel cell carcinoma viral status with prognosis have inconsistent findings. Moshiri et al. Read More

    The role of imaging in the management of patients with nonmelanoma skin cancer: When is imaging necessary?
    J Am Acad Dermatol 2017 Apr;76(4):591-607
    Department of Dermatology, MD Anderson Cancer Center, Houston, Texas.
    When treating aggressive skin cancers, pre- and postoperative imaging provides important information for treatment planning and multidisciplinary cooperation of care. It is important for dermatologists to recognize the clinical scenarios where imaging is indicated in the management of skin cancer. We here address the most common indications for imaging in cutaneous oncology and how to best utilize the modalities available. Read More

    The role of imaging in the management of patients with nonmelanoma skin cancer: Diagnostic modalities and applications.
    J Am Acad Dermatol 2017 Apr;76(4):579-588
    Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:
    While uncomplicated cases of nonmelanoma skin cancer can be treated with surgery, destruction, or topical therapy alone, advanced or neglected cases require more complex management decisions. Dermatologists and dermatologic surgeons should be familiar with the imaging techniques relevant to cutaneous oncology and their value in different clinical scenarios. Herein we review imaging modalities used in management of nonmelanoma skin cancer. Read More

    Primary Cribriform Carcinoma of the Eyelid With Neuroendocrine Features: A Case Report.
    J Drugs Dermatol 2017 Feb;16(2):173-174
    A variety of tumors may involve the eyelid, most of which are primary, but rarely can be metastatic. Previously reported eyelid primary carcinomas with neuroendocrine features include Merkel cell carcinoma, apocrine and eccrine gland carcinoma, sebaceous gland carcinoma, and one report of primary "well-differentiated neuroendocrine tumor." Herein we report the first case of primary cribriform carcinoma of the eyelid with neuroendocrine features. Read More

    Erratum to: Metastatic Merkel cell carcinoma response to nivolumab.
    J Immunother Cancer 2017 6;5:27. Epub 2017 Mar 6.
    Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, C451 Med Inn, 1500 East Medical Center Drive, Ann Arbor, MI 48109 USA.
    [This corrects the article DOI: 10.1186/s40425-016-0186-1.]. Read More

    Planning study for Merkel cell carcinoma based on the relapse pattern.
    Radiother Oncol 2017 Apr 8;123(1):154-157. Epub 2017 Mar 8.
    Radiation Oncology, Charité University Medicine Berlin, Germany.
    Purpose: To develop a technique for radiation (RT) of in-transit path ways (IT) in Merkel cell carcinoma.

    Method: In the planning study, IT were ink-marked on the skin during sentinel lymphscintigraphy and wire-marked in planning-CT. Pre- and post-operative planning-CTs were acquired. Read More

    New developments in the biology and the treatment of metastatic Merkel cell carcinoma.
    Curr Opin Oncol 2017 Mar 9. Epub 2017 Mar 9.
    aDepartment of Dermatology, University of Lübeck, Lübeck bTranslational Skin Cancer Research, German Cancer Consortium (DKTK), Department of Dermatology and the West German Cancer Center, Essen University Hospital, Essen, Germany.
    Purpose Of Review: Patients with stage IIIB und IV metastatic Merkel cell carcinoma (mMCC), who are not suitable candidates for surgery or radiotherapy, are unlikely to achieve lasting remission or tumor control by chemo or targeted therapy. In the majority of cases, the tumor arises from viral carcinogenesis associated with the Merkel cell polyomavirus (MCPyV). In MCPyV-negative tumors with a presumable ultraviolet carcinogenesis, a high mutational burden resulting in neoantigens was discovered. Read More

    Reduced H3K27me3 expression in Merkel cell polyoma virus-positive tumors.
    Mod Pathol 2017 Mar 10. Epub 2017 Mar 10.
    Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
    Merkel cell carcinoma is a primary cutaneous neuroendocrine carcinoma, which once metastatic is difficult to treat. Recent mutation analyses of Merkel cell carcinoma revealed a low number of mutations in Merkel cell polyomavirus-associated tumors, and a high number of mutations in virus-negative combined squamous cell and neuroendocrine carcinomas of chronically sun-damaged skin. We speculated that the paucity of mutations in virus-positive Merkel cell carcinoma may reflect a pathomechanism that depends on derangements of chromatin without alterations in the DNA sequence (epigenetic dysregulation). Read More

    Avelumab: combining immune checkpoint inhibition and antibody-dependent cytotoxicity.
    Expert Opin Biol Ther 2017 Apr 22;17(4):515-523. Epub 2017 Feb 22.
    a Department of Surgery , Medical University of Vienna , Vienna , Austria.
    Introduction: Immune checkpoint inhibition holds great promise for selected tumors. The human monoclonal antibody (mAB) avelumab is directed to programmed death ligand-1 (PD-L1) and is supposed to inhibit the immunosuppressive PD-L1/PD-1 interaction and, furthermore, effect antibody-dependent cytotoxicity (ADCC) lysis of tumor cells. Areas covered: This article presents an overview of the current means to activate the antitumor immune defense by targeting PD-1 or PD-L1 with mABs and their possible role in ADCC-mediated tumor cell elimination. Read More

    Topics in histopathology of sweat gland and sebaceous neoplasms.
    J Dermatol 2017 Mar;44(3):315-326
    Division of Dermatology and Dermatopathology, Nippon Medical School Musashi Kosugi Hospital, Kawasaki City, Japan.
    This article reviews several topics regarding sweat gland and sebaceous neoplasms. First, the clinicopathological characteristics of poroid neoplasms are summarized. It was recently reported that one-fourth of poroid neoplasms are composite tumors and one-fourth are apocrine type lesions. Read More

    Potential Activity of Amrubicin as a Salvage Therapy for Merkel Cell Carcinoma.
    Intern Med 2017 1;56(5):567-570. Epub 2017 Mar 1.
    Department of Hematology, Graduate School of Medicine, Chiba University, Japan.
    Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin with an aggressive clinical course. Although anthracycline- and platinum-based regimens are empirically used as first-line treatments for metastatic or unresectable cases, no salvage therapy has been established. A 73-year-old man with platinum-refractory recurrent MCC was treated with amrubicin. Read More

    Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: What Is New in the 2017 WHO Blue Book for Tumors and Tumor-Like Lesions of the Neck and Lymph Nodes.
    Head Neck Pathol 2017 Mar 28;11(1):48-54. Epub 2017 Feb 28.
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
    The World Health Organization (WHO) 2017 Classification of Head and Neck Tumors ("Blue Book") will now include a new chapter on tumors and tumor-like lesions of the neck and lymph nodes, which was not included in the previous edition. Tumors and tumor-like lesions, including a variety of cysts and metastases, can arise in any component in the neck, including soft tissue, lymph nodes, and developmental remnants. The pathology and clinical features of metastatic carcinoma of unknown primary in the head and neck has changed dramatically in the last several years. Read More

    Molecular prevalence of Merkel cell polyomavirus in nonmelanoma skin cancer in a Brazilian population.
    Clin Exp Dermatol 2017 Feb 27. Epub 2017 Feb 27.
    Department of Clinical Medicine, Universidade Federal Fluminense, Hospital Universitário Antônio Pedro, Niterói, Rio de Janeiro, Brazil.
    Background: Merkel cell polyomavirus (MCPyV), a newly described oncogenic virus, has been found in association with tumours other than Merkel cell carcinoma (MCC). As yet, little is known about the involvement or influence of MCPyV on the development of these tumours and its prevalence in various populations.

    Aim: To assess the prevalence of MCPyV DNA in cases of nonmelanoma skin cancer (NMSC). Read More

    A Rare Case of CK20/CK7 Double Negative Merkel Cell Carcinoma.
    Am J Dermatopathol 2017 Mar;39(3):208-211
    *Department of Pathology, University of California Los Angeles, Los Angeles, CA; †Southern California Permanente Medical Group, Department of Dermatology, Sunset Medical Center, Los Angeles, CA; and ‡Department of Pathology, Kaiser Southern California Permanente Medical Group, Los Angeles, CA.
    The authors present a case of Merkel cell carcinoma (MCC) with unique immunohistochemical staining characteristics. A 57-year-old woman presented with a firm 0.3 cm tan papule on her left nasal-labial fold that was reportedly increasing in size and bleeding. Read More

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