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Eur J Radiol 2021 Apr 26;139:109736. Epub 2021 Apr 26.

Department of Health Sciences (DISSAL). University of Genoa, Genoa, Italy. Electronic address:

Purpose: To compare ultrasound (US)-guided injections and surgery for the treatment of meralgia paresthetica (lateral femoral cutaneous neuropathy).

Methods: Two reviewers, independently, up to 10 October 2020 retrieved Studies that assessed the outcome of US-guided injections and surgery for the treatment of meralgia paresthetica from major medical libraries. Predefined inclusion and exclusion criteria were adopted. Read More

In Vivo 2021 May-Jun;35(3):1537-1543

Department of Neurosurgery, Adatip Hospital, Istanbul, Turkey

Background/aim: Neuropathic pain and neuropathy is commonly seen after ischemia-reperfusion injuries. Our aim was to evaluate the effect of lutein on ischemia-reperfusion (I/R)-induced vasculitic neuropathic pain and neuropathy in rats.

Materials And Methods: An hour before anesthesia, 6 Albino Wistar male rats with I/R were orally administered with 1 mg/kg lutein (LIR group). Read More

Cureus 2021 Mar 17;13(3):e13937. Epub 2021 Mar 17.

Neurology, Flowers Medical Group, Dothan, USA.

Meralgia paresthetica, a condition characterized by tingling, numbness, and burning pain in the lateral aspect of the thigh, is caused by compression of the lateral femoral cutaneous nerve. The incidence of meralgia paresthetica increases with obesity and diabetes. The unique anatomy of the nerve that tunnels through the inguinal ligament predisposes it to inflammation, trauma, and entrapment. Read More

J Anaesthesiol Clin Pharmacol 2020 Oct-Dec;36(4):450-457. Epub 2020 Sep 26.

Consultant Orthopaedics, Orthomax Hospital, Panchkula, Haryana, India.

Chronic hip pain is distressing to the patient as it not only impairs the daily activities of life but also affects the quality of life. Chronic hip pain is difficult to diagnose as patients often present with associated chronic lumbar spine and/or knee joint pain. Moreover, nonorthopaedic causes may also present as chronic hip pain. Read More

Cureus 2021 Mar 5;13(3):e13723. Epub 2021 Mar 5.

Internal Medicine-Pediatrics, Icahn School of Medicine at Mount Sinai, New York, USA.

Popliteal entrapment syndrome is an uncommon cause of intermittent claudication in young patients lacking atherosclerotic risk factors. ZS is a 16-year-old cisgender female with type 1 diabetes complicated by microalbuminuria, obesity (body mass index (BMI) = 45.86 kg/m²), and a history of perinatal stroke with residual right-sided hemiparesis, who presented with six months of worsening bilateral, exertional lower extremity pain. Read More

JBJS Case Connect 2021 04 2;11(2). Epub 2021 Apr 2.

Department of Orthopedic Surgery, Marugame Medical Center, Kagawa, Japan.

Case: A 51-year-old woman presented with a 2-month history of pain in the right thigh. Radiography and computed tomography of the pelvis showed cortical hyperostosis of the right ilium. She was diagnosed with meralgia paresthetica (MP) caused by melorheostosis involving the right ilium. Read More

Korean J Anesthesiol 2021 Mar 31. Epub 2021 Mar 31.

Anesthesia Critical Care and Pain Management Department. Valencia University General Hospital. Tres Creus Avenue, 2, 46014 Valencia (Spain).

Muscle Nerve 2021 Mar 13. Epub 2021 Mar 13.

Laboratoire d'électroneuromyographie, Paris, France.

J Orthop Case Rep 2020 Nov;10(8):80-83

Department of Orthopedic Surgery, Interbalkan European Medical Centre, Asklipiou Street 10, 55535, Thessaloniki ,Greece.

Introduction: Meralgia paresthetica (MP) is a clinical syndrome usually resulting usually from compression of the lateral femoral cutaneous nerve (LFCN). Tumors arising from this nerve could also be the cause of this syndrome.

Case Report: We present an unusual cause of MP in a 67-year-old Caucasian male. Read More

J Orthop Surg Res 2021 Mar 11;16(1):184. Epub 2021 Mar 11.

Joint Reconstruction Research Center, Department of Orthopedics, Tehran University of Medical Sciences, Keshavarz Boulevard, Tehran, 1419733141, Iran.

Background: Orthopedic manifestations of congenital insensitivity to pain (CIP) can be devastating if left untreated. Knee deformities are common in patients with CIP and might lead to joint destruction and loss of walking ability. The purpose of the present study was to report the results and complications of guided growth procedures around the knee in patients with CIP. Read More

Gene Ther 2021 Mar 10. Epub 2021 Mar 10.

Neuroscience Department, The Cyprus Institute of Neurology and Genetics and Cyprus School of Molecular Medicine, Nicosia, Cyprus.

Mutations in the GJB1 gene, encoding the gap junction (GJ) protein connexin32 (Cx32), cause X-linked Charcot-Marie-Tooth disease (CMT1X), an inherited demyelinating neuropathy. We developed a gene therapy approach for CMT1X using an AAV9 vector to deliver the GJB1/Cx32 gene under the myelin protein zero (Mpz) promoter for targeted expression in Schwann cells. Lumbar intrathecal injection of the AAV9-Mpz. Read More

J Nippon Med Sch 2021 Mar 9. Epub 2021 Mar 9.

Department of Neurosurgery, Nippon Medical School.

Objective: Meralgia paresthetica (MP) is an entrapment neuropathy of the lateral femoral cutaneous nerve (LFCN). We report a rare MP complication after microvascular decompression (MVD) surgery in the park-bench position in a patient with hemi-facial spasm.

Case: The patient was a 46-year-old female (height: 155 cm, weight: 42 kg). Read More

BMC Musculoskelet Disord 2021 Mar 10;22(1):261. Epub 2021 Mar 10.

Department of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.

Background: Altered circulating levels and genetic variation of B-type natriuretic peptide (BNP), has been associated with lower bone mineral density (BMD) values and incidence of osteoporosis in peritoneal dialysis patients, renal transplant recipients, and postmenopausal women. The potential relationship of circulating BNP with osteoporosis in patients with type 2 diabetes mellitus (T2DM), however, has not yet been studied.

Methods: Circulating BNP levels were measured in 314 patients with T2DM, and participants were divided into normal BMD group (n = 73), osteopenia group (n = 120), and osteoporosis group (n = 121). Read More

World Neurosurg 2021 May 27;149:e29-e35. Epub 2021 Feb 27.

Department of Clinical Neurophysiology, Haaglanden Medical Center, The Hague, The Netherlands.

Objective: Sometimes during surgery for meralgia paresthetica, it can be difficult to find the lateral femoral cutaneous nerve (LFCN). The aims of this study were to study the prevalence of different anatomical variations in patients, compare preoperative ultrasound (US) data with intraoperative findings, and investigate the effect of type of anatomical variation on duration of surgery and success rate of localizing the LFCN.

Methods: Fifty-four consecutive patients with idiopathic meralgia paresthetica who underwent either a neurolysis or neurectomy procedure were included. Read More

Cardiovasc Diabetol 2021 Feb 27;20(1):54. Epub 2021 Feb 27.

Department of Internal Medicine, University Hospital Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro, Rua Croton, 72, Jacarepagua, Rio de Janeiro, RJ, CEP: 22750-240, Brazil.

Background: The prognostic importance of non-traditional risk factors for peripheral artery disease (PAD) development/progression is scarcely studied in diabetes. We investigated if carotid intima-media thickness (CIMT) and carotid-femoral pulse wave velocity (cf-PWV) added prognostic information beyond traditional cardiovascular risk markers for PAD outcomes.

Methods: Ankle-brachial index (ABI) was measured at baseline and after a median of 91 months of follow-up in 681 individuals with type 2 diabetes. Read More

Muscle Nerve 2021 Feb 12. Epub 2021 Feb 12.

Department of Neurology, Boston Medical Center, Boston, Massachusetts, USA.

Pain Manag 2021 Apr 11;11(4):389-393. Epub 2021 Feb 11.

Department of Orthopedics & Traumatology, University of Health Sciences, Derince Training & Research Hospital, Kocaeli, Turkey.

Meralgia paresthetica (MP) is a painful mononeuropathy that causes paresthesia, tingling, stinging or a burning sensation in the thigh's anterolateral part due to the entrapment of the lateral femoral cutaneous nerve under the inguinal ligament. The treatment options for MP include conservative or interventional management and must follow an algorithm. The objective is to eliminate the underlying cause if known. Read More

Curr Pain Headache Rep 2021 Feb 5;25(2):11. Epub 2021 Feb 5.

Beth Israel Deaconess Medical Center, Department of Anesthesiology, Critical Care, and Pain Medicine, Harvard Medical School, Boston, MA, USA.

Purpose Of Review: This is a comprehensive review of the literature regarding post-surgical cutaneous nerve entrapment, epidemiology, pathophysiology, and clinical presentation. It focuses mainly on nerve entrapment leading to chronic pain and the available therapies.

Recent Findings: Cutaneous nerve entrapment is not an uncommon result (up to 30% of patients) of surgery and could lead to significant, difficult to treat chronic pain. Read More

Lakartidningen 2021 02 3;118. Epub 2021 Feb 3.

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Meralgia paresthetica (MP) is an entrapment syndrome that may cause loss of sensation, numbness, paresthesia and pain within the distribution of the lateral femoral cutaneous nerve. This condition is more common in persons with diabetes mellitus, obesity and in old age. MP has previously been described in patients that have undergone surgery in the prone position (PP) and in a case report of a patient with ARDS (Acute Respiratory Distress Syndrome) who was cared for in the intensive care unit (ICU). Read More

Innov Clin Neurosci 2020 Jul;17(7-9):10-11

Drs. Calabrò and Manuli are with IRCCS Centro Neurolesi "Bonino Pulejo" in Messina, Italy.

Meralgia paresthetica (MP) is an uncommon entrapment mononeuropathy that is characterized by a sudden onset of paresthesia and numbness in the anterolateral surface of the thigh. Palmithoylethanolamide (PEA) is commonly used in the treatment of chronic pelvic pain and compressive neuropathies. Herein, we describe an otherwise healthy 28-year-old patient affected by posttraumatic MP for three months who was successfully treated with PEA (1200mg/day). Read More

BMJ Case Rep 2021 Jan 18;14(1). Epub 2021 Jan 18.

Orthopaedic Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.

We report the case of a 68-year-old man who was placed on heparin as bridge therapy and subsequently developed an iliacus haematoma with associated femoral nerve palsy. His team involved the orthopaedic surgery team in delayed fashion after his symptom onset. Due to his active medical conditions, he did not undergo surgical decompression of his haematoma until late into his hospital course. Read More

J Neurosurg 2021 Jan 15:1-11. Epub 2021 Jan 15.

1Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida; and.

Objective: Meralgia paresthetica is caused by entrapment of the lateral femoral cutaneous nerve (LFCN) and often presents with pain. Multiple treatment options targeting the LFCN can be pursued to treat the pain should conservative measures fail, with the most common options being injection, neurolysis, and neurectomy. However, their efficacy in causing pain relief and their clinical outcomes have yet to be directly compared. Read More

J Neurol 2021 Jan 13. Epub 2021 Jan 13.

Departments of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Objective: To systematically describe central (CNS) and peripheral (PNS) nervous system complications in hospitalized COVID-19 patients.

Methods: We conducted a prospective, consecutive, observational study of adult patients from a tertiary referral center with confirmed COVID-19. All patients were screened daily for neurological and neuropsychiatric symptoms during admission and discharge. Read More

Cureus 2020 Dec 5;12(12):e11927. Epub 2020 Dec 5.

Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, USA.

The diagnosis and management of postoperative nerve injury can be a challenging and frustrating proposition for the patient, surgeon, and anesthesia provider. Unfortunately, in many cases, the true etiology is never elucidated and the injury is ascribed to positioning or a nerve block with "expectant management" being the order of the day, which can result in persistent disability for the patient. However, there is a rare subset of disorders affecting the nervous system that can masquerade as a peripheral nerve injury that warrants further investigation of risk factors and co-morbidities when other common causes of nerve injury are ruled out. Read More

BMC Surg 2021 Jan 7;21(1):30. Epub 2021 Jan 7.

Department of Hand Surgery, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, 130041, Jilin, China.

Background: A hibernoma, also known as a brown fat tumor, is a rare benign soft tissue tumor, which originates from brown adipose tissue remaining in the fetus after the gestational period. It is often detected in adult men, presenting as a painless slow-growing mass. Hibernomas of the thigh have been reported; however, motor and sensory disorders caused by the tumors compressing the femoral nerve have not been reported. Read More

Int J Surg Case Rep 2020 19;77:787-790. Epub 2020 Nov 19.

Department of Endovascular & Vascular Surgery, Geisinger Medical Center, Danville, PA, United States.

Introduction: Persistent sciatic artery (PSA) is a rare embryological vascular anomaly with a prevalence between 0.025-0.06%. Read More

Ann Vasc Surg 2020 Dec 26. Epub 2020 Dec 26.

DFW Vascular Group, Dallas, TX; Surgery, Methodist Dallas Medical Center, Dallas, TX; TCU School of Medicine, Ft. Worth, TX. Electronic address:

Background: Subclavian vein and brachiocephalic vein occlusions are challenging problems in dialysis patients with ipsilateral upper extremity (UE) vascular access or in need of one. HeRO grafts (Hemodialysis Reliable Outflow, Merit Medical Systems, Inc, South Jordan, UT) have been used to manage such occlusions but patients with chronic hypotension treated with HeRO graft may have threatened patency. We describe an alternative technique using a supraclavicular stent graft to reconstruct the venous outflow, evaluate outcomes of this procedure, and discuss its role in complex hemodialysis patients. Read More

Turk J Phys Med Rehabil 2020 Dec 26;66(4):473-475. Epub 2020 Feb 26.

Department of Physical Medicine and Rehabilitation, Marmara University School of Medicine, Istanbul, Turkey.

Mechanical compression at any point along the lateral femoral cutaneous nerve (LFCN) may result in meralgia paresthetica (MP). A 54-year-old male patient presented with pain and tingling on the anterolateral side of thigh. After excluding other causes of pain radiating to legs, he was diagnosed with MP. Read More

Anaesthesia 2021 05 22;76(5):712-713. Epub 2020 Dec 22.

Glasgow Royal Infirmary, Glasgow, UK.

Medicine (Baltimore) 2020 Dec;99(50):e23497

Department of Physical Medicine and Rehabilitation, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.

Rationale: Hematoma of the iliopsoas muscle is a rare condition. Prolonged pressure conditions due to hematoma of the femoral nerve can cause severe pain in the affected groin, hip, and thigh, and quadriceps weakness. We report a rare case of a spontaneous iliopsoas muscle hematoma that caused sudden femoral neuropathy. Read More