565,117 results match your criteria Mental health in family medicine[Journal]


Prevalence and clinical correlations of obsessive-compulsive symptoms in schizophrenia.

Asian J Psychiatr 2018 Nov 27;39:48-52. Epub 2018 Nov 27.

Department of Psychiatry, Centre of Excellence in Mental Health, PGIMER Dr RML Hospital, New Delhi, India. Electronic address:

Introduction: Obsessive compulsive symptoms are often present in persons with schizophrenia. Adequately powered studies to evaluate the effect of such symptoms in the course of the disorder, are few.

Aim: We aimed to estimate the prevalence and type of obsessive-compulsive symptoms in persons with schizophrenia. Read More

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November 2018

Networks of problems: social, psychological, and genetic influences on health.

Curr Opin Psychol 2018 Nov 30;27:88-92. Epub 2018 Nov 30.

Department of Sociology, Stanford University, United States.

An emerging idea in psychopathology conceives of disorders as networks of mutually-reinforcing symptoms that constitute the disorder rather than simply reflect it. This is similar to how social scientists already view socioeconomic status, and has affinities to how physical health problems compound in later life. Social, psychological, and physical conditions might therefore be thought of as networks of problems with 'causal bridges' that span different levels and bring low SES, mental health challenges, and physical health problems into pervasive relationships with one another. Read More

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November 2018

Relationship between anxiety, depression, sex, obesity, and internet addiction in Chinese adolescents: A short-term longitudinal study.

Addict Behav 2018 Dec 7;90:421-427. Epub 2018 Dec 7.

Research Institute on Addictions, University at Buffalo, State University of New York, Buffalo, NY, United States. Electronic address:

Associations between anxiety, depression and adolescent Internet addiction have been well documented in the literature; however, few published studies have examined these relationships considering the developmental trajectory courses of adolescent Internet addiction as well as the individual differences over time. Using a sample of 1545 Chinese adolescents and 3 waves of data over six months, we examined the longitudinal associations between anxiety and depression and Internet addiction, considering sex and obesity. We used latent growth curve modeling (LGCM) to examine the overall conditions of Internet addiction, and latent class growth modeling (LCGM) to determine adolescent developmental membership for Internet addiction. Read More

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December 2018

Disrupted structural and functional brain networks in Alzheimer's disease.

Neurobiol Aging 2018 Nov 16;75:71-82. Epub 2018 Nov 16.

Dementia Care & Research Center, Peking University Institute of Mental Health (Sixth Hospital), Beijing, China; Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Beijing, China; National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China. Electronic address:

Studies have demonstrated that the clinical manifestations of Alzheimer's disease (AD) are associated with abnormal connections in either functional connectivity networks (FCNs) or structural connectivity networks (SCNs). However, the FCN and SCN of AD have usually been examined separately, and the results were inconsistent. In this multimodal study, we collected resting-state functional magnetic resonance imaging and diffusion magnetic resonance imaging data from 46 patients with AD and 39 matched healthy controls (HCs). Read More

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November 2018
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The association between the longitudinal course of common mental disorders and subsequent physical activity status in young adults: A 30-year birth cohort study.

J Psychiatr Res 2018 Dec 6;109:173-177. Epub 2018 Dec 6.

Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia; School of Public Health, The University of Queensland, Herston, Australia; Metro North Mental Health, Royal Brisbane and Women's Hospital, Herston, Australia.

Low physical activity is a major public health concern. There has been extensive research examining the role of physical activity as a potentially modifiable risk factor for the onset of mental illness. However, fewer studies have reported how mental disorders affect future physical activity. Read More

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December 2018
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Predictors of self-harm emergency department visits in adolescents: A statewide longitudinal study.

Gen Hosp Psychiatry 2018 Dec 8;56:28-35. Epub 2018 Dec 8.

Violence Prevention Research Program, University of California, Davis, Sacramento, CA 95817, USA. Electronic address:

Objective: This study investigated patient- and area-level characteristics associated with adolescent emergency department (ED) patients' risk of subsequent ED visits for self-harm.

Method: Retrospective analysis of adolescent patients presenting to a California ED in 2010 (n = 480,706) was conducted using statewide, all-payer, individually linkable administrative data. We examined associations between multiple predictors of interest (patient sociodemographic factors, prior ED utilization, and residential mobility; and area-level characteristics) and odds of a self-harm ED visit in 2010. Read More

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December 2018

Fluorodeoxyglucose positron emission tomography studies of the schizophrenia spectrum: The legacy of Monte S. Buchsbaum, M.D.

Psychiatry Res 2018 Dec 7;271:535-540. Epub 2018 Dec 7.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Mental Illness Research, Education, and Clinical Center (VISN 2), James J. Peters VA Medical Center, 130 West Kingsbridge Road, Room 6A-44, Bronx, NY, United States.

This is a selective review of the work of Buchsbaum and colleagues. It revisits and pays tribute to four decades of publications employing positron emission tomography (PET) with fluorodeoxyglucose (FDG) to examine the neurobiology of schizophrenia-spectrum disorders (including schizotypal personality disorder (SPD) and schizophrenia). Beginning with a landmark FDG-PET study in 1982 reporting hypofrontality in unmedicated schizophrenia patients, Buchsbaum and colleagues published high-impact work on regional glucose metabolic rate (GMR) abnormalities in the spectrum. Read More

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December 2018

A framework for offline evaluation and optimization of real-time algorithms for use in neurofeedback, demonstrated on an instantaneous proxy for correlations.

Neuroimage 2018 Dec 12. Epub 2018 Dec 12.

Section on Functional Imaging Methods, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.

Interest in real-time fMRI neurofeedback has grown exponentially over the past few years, both for use as a basic science research tool, and as part of the search for novel clinical interventions for neurological and psychiatric illnesses. In order to expand the range of questions which can be addressed with this tool however, new neurofeedback methods must be developed, going beyond feedback of activations in a single region. These new methods, several of which have already been proposed, are by their nature complex, involving many possible parameters. Read More

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December 2018
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Transcranial static magnetic stimulation over the primary motor cortex alters sequential implicit motor learning.

Neurosci Lett 2018 Dec 12. Epub 2018 Dec 12.

Graduate School of Core Ethics and Frontier Sciences, Ritsumeikan University, Japan. Electronic address:

Transcranial static magnetic stimulation (tSMS) is a recently introduced noninvasive brain stimulation technique that can modulate brain excitability. Here, we investigated a hypothesis that motor learning would be altered by tSMS applied to the primary motor cortex (M1). For motor task, we chose a serial reaction time task consisting of sequential trials and random trials in which the visual cue doesn't play out a repeating pattern of positions to evaluate an implicit motor learning, where the M1 is a key structure for skill acquisition and early consolidation. Read More

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December 2018

Non-Muscle Invasive Bladder Cancer Influences Physical Health Related Quality of Life and Urinary Incontinence.

Urology 2018 Dec 12. Epub 2018 Dec 12.

University of Washington, Department of Urology. Electronic address:

Objective: To evaluate the effects of non-muscle invasive bladder cancer (NMIBC) on health-related quality of life (HRQOL) and urinary function within patients diagnosed with NMIBC as compared to the general population.

Methods: Using the Surveillance, Epidemiology, and End Results-Medicare Health Outcome Survey (SEER-MHOS) database (1998-2013), 325 patients diagnosed with NMIBC with baseline and post-diagnosis MHOS surveys were propensity-matched 1:5 to non-cancer controls (NCC). Multivariate linear regression analysis compared NMIBC patients with matched NCC in terms of physical component summary (PCS), mental component summary (MCS), and health domain scales. Read More

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December 2018

Differential executive functioning in young adulthood as a function of experienced child abuse.

Int J Psychophysiol 2018 Dec 12. Epub 2018 Dec 12.

University of North Dakota, United States of America.

Introduction: Previous research has shown cognitive dysfunction in adults with a history of child abuse. The purpose of the present study was to measure differences that exist in executive functioning skills between individuals who have been abused as children versus those without the history of childhood abuse.

Methods: The present study recruited 43 students from the University of North Dakota (33 women) between ages 18 and 23 years of age. Read More

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December 2018

Molecular Mechanisms of Glutaredoxin Enzymes: Versatile Hubs for Thiol-Disulfide Exchange between Protein Thiols and Glutathione.

J Mol Biol 2018 Dec 12. Epub 2018 Dec 12.

School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.

The tripeptide glutathione (GSH) and its oxidized form glutathione disulfide (GSSG) constitute a key redox couple in cells. In particular, they partner protein thiols in reversible thiol-disulfide exchange reactions that act as switches in cell signaling and redox homeostasis. Disruption of these processes may impair cellular redox signal transduction and induce redox misbalances that are linked directly to aging processes and to a range of pathological conditions including cancer, cardiovascular diseases and neurological disorders. Read More

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December 2018

Association of allostatic load with health-related quality of life in patients with arterial hypertension: a cross-sectional analysis.

Swiss Med Wkly 2018 Dec 15;148:w14689. Epub 2018 Dec 15.

Department of Medical Psychology and Psychotherapy, Medical University of Graz, Austria / Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Austria.

Aims Of The Study: Allostatic load (AL), as a marker of cumulative stress, is associated with higher morbidity and mortality, and reduced health-related quality of life (HrQoL) in healthy adults. In patients with hypertension, AL and its association with HrQoL have not been investigated. Therefore, this study aimed to (1) explore AL in a cohort of hypertensive patients and to (2) determine its association with HrQoL, while controlling for other health-related variables. Read More

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December 2018

WPA Position Statement on Spirituality and Religion in Psychiatry.

Actas Esp Psiquiatr 2018 Nov 1;46(6):242-8. Epub 2018 Nov 1.

WPA Sección Sobre Religión, Espiritualidad y Psiquiatría Departamento de Teología y Religión, Universidad de Durham, Durham, UK.

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November 2018

Factors predicting early dropout from dialectical behaviour therapy in individuals with borderline personality disorder.

Actas Esp Psiquiatr 2018 Nov 1;46(6):226-33. Epub 2018 Nov 1.

Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Barcelona (Spain) Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona (Spain) Institut d'Investigació Biomèdica- Sant Pau (IIB-SANT PAU), Barcelona (Spain) Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM (Spain).

Background: Dialectical behaviour therapy skills training (DBT-ST) has proven effective to treat individuals with borderline personality disorder (BPD). However, therapy still faces the problem of early dropout. The aim of the present study is to examine which factors are associated with early dropout from DBT-ST in a sample of subjects with BPD. Read More

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November 2018

Sexual dysfunction factors in patients with schizophrenia treated with second generation antipsychotics: not only prolactin.

Actas Esp Psiquiatr 2018 Nov 1;46(6):217-25. Epub 2018 Nov 1.

Unidad de Gestión Clínica de Salud Mental. Hospital Universitario de Valme. Sevilla. España.

Introduction: Despite the high prevalence of sexual dysfunction in patients with schizophrenia, its origins are still unclear.

The Aim Of This Study: to determine the prevalence and causal factors of sexual dysfunction in a group of outpatients with schizophrenia.

Methods: The study was designed to be cross-sectional and naturalistic, including outpatients with schizophrenia undergoing second generation antipsychotic monotherapy. Read More

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November 2018

Interneuron NMDA receptors change the gear of motor learning in the cerebellar machine.

J Physiol 2018 Dec 15. Epub 2018 Dec 15.

Program in Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, M5G 1×8, Canada.

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December 2018

Patterns of altered regional brain glucose metabolism in borderline personality disorder and bipolar II disorder.

Acta Psychiatr Scand 2018 Dec 15. Epub 2018 Dec 15.

Institute of Clinical Medicine, University of Oslo, Norway.

Objective: The relationship between borderline personality disorder (BPD) and bipolar II disorder (BIP-II) is disputed but understudied. Here, we investigated brain glucose metabolism in these patient groups and healthy control subjects (HCs).

Methods: Sixty-five subjects, 22 BPD (19 females); 22 BIP-II (17 females); 21 HC (14 females) were examined using 2-deoxy-2[18F]-fluoro-d-glucose Positron-Emission Tomography (PET) scanning. Read More

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December 2018

Blood pressure reactivity at onset of mental stress determines sympathetic vascular response in young adults.

Physiol Rep 2018 Dec;6(24):e13944

School of Medicine, Western Sydney University, Sydney, New South Wales, Australia.

We have previously shown in young males that the rate of rise in blood pressure (BP) at the onset of mental stress determines whether or not muscle sympathetic nerve activity (MSNA) has a role in driving the pressor response. The aim of this study was to investigate these interactions in young females. BP and MSNA were recorded continuously in 19 females and 21 males during 2-min mental stressors (mental arithmetic and Stroop test). Read More

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December 2018

Extracorporeal shock wave lithotripsy is safe and effective for geriatric patients with chronic pancreatitis.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology, The Second Military Medical University, Shanghai, China.

Background & Aims: Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is first-line treatment for chronic pancreatitis (CP) patients with pancreatic stones. However, the performance of P-EWSL in geriatric patients remains unclear. We aimed to evaluate the safety and efficacy of P-ESWL for them. Read More

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December 2018

Exploring the mediating role of self-blame and coping in the relationships between self-compassion and distress in females following the sexual assault.

J Clin Psychol 2018 Dec 15. Epub 2018 Dec 15.

Department of Psychology, University of Tennessee, Knoxville, Tennessee.

Objective: The present study investigated the associations between self-compassion, self-blame, disengagement coping, and posttraumatic stress disorder (PTSD) and depression symptom severity among females who had experienced sexual assault. We also examined whether the relationships between self-compassion and both PTSD and depression severity were mediated by self-blame and coping.

Method: A volunteer sample of female adults (N = 207) completed surveys online or on paper. Read More

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December 2018

In Schizophrenia, Increased Plasma IgM/IgA Responses to Gut Commensal Bacteria Are Associated with Negative Symptoms, Neurocognitive Impairments, and the Deficit Phenotype.

Neurotox Res 2018 Dec 15. Epub 2018 Dec 15.

Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Increased gut permeability (leaky gut) with increased translocation of Gram-negative bacteria plays a role in the gut-brain axis through effects on systemic immune-inflammatory processes. Deficit schizophrenia is characterized by an immune-inflammatory response combined with a deficit in natural IgM antibodies to oxidative-specific epitopes (OSEs), which are a first-line defense against bacterial infections. This study measured plasma IgA/IgM responses to 5 Gram-negative bacteria in association with IgM responses to malondialdehyde (MDA) and azelaic acid in 80 schizophrenia patients (40 with the deficit syndrome and 40 without) and in 38 healthy controls. Read More

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December 2018

Pitfalls in the triage and evaluation of patients with suspected acute ethanol intoxication in an emergency department.

Intern Emerg Med 2018 Dec 14. Epub 2018 Dec 14.

Division of Emergency Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals and Geneva University, Faculty of Medicine, Geneva, Switzerland.

Acute ethanol intoxication (AEI) is frequent in emergency departments (EDs). These patients are at risk of mistriage, and to leave the ED without being seen. This study's objective was to describe the process and performance of triage and trajectory for patients with suspected AEI. Read More

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December 2018

The role of adverse childhood experiences and mental health care use in psychological dysfunction of male multi-problem young adults.

Eur Child Adolesc Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

Department of Child and Adolescent Psychiatry, Amsterdam UMC, University of Amsterdam, Meibergdreef 5, 1105 AZ, Amsterdam, The Netherlands.

Adverse childhood experiences (ACEs) are associated with severe problems later in life. This study examines how eleven types of ACEs and mental health care use history are related to current psychological dysfunction among multi-problem young adults. A sample of 643 multi-problem young adult men (age 18-27) gave informed consent for us to collect retrospective regional psychiatric case register data and filled out questionnaires. Read More

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December 2018

Barriers and facilitators to understanding of ADHD in primary care: a mixed-method systematic review.

Eur Child Adolesc Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

Division of Psychiatry & Applied Psychology, University of Nottingham, Nottingham, UK.

Attention deficit hyperactivity disorder (ADHD) is a developmental disorder affecting up to 5% of children and adults and is underdiagnosed in many European countries. The process of access to care for this disorder is complex and variable across countries. In general, those affected, or their caregiver, will seek help through their primary care practitioners who are then often responsible for referral to other professionals for diagnosis and provision of treatment. Read More

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December 2018

Sex differences in somatomotor representations of others' pain: a permutation-based analysis.

Brain Struct Funct 2018 Dec 14. Epub 2018 Dec 14.

Ahmanson-Lovelace Brain Mapping Center, Brain Research Institute, UCLA, Los Angeles, CA, USA.

Sex differences in empathy for pain have been repeatedly observed. However, it is unclear whether this is due to sex differences in "bottom-up" somatomotor representations of others' pain (self-other resonance) or to "top-down" prefrontal control of such responses. Here, we provide data from 70 subjects suggesting that sex differences in empathy for pain lie primarily in pre-reflective, bottom-up resonance mechanisms. Read More

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December 2018

Substance Use and Depression Among Recently Migrated African Gay and Bisexual Men Living in the United States.

J Immigr Minor Health 2018 Dec 14. Epub 2018 Dec 14.

HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, 1051 Riverside Drive, Unit 15, New York, NY, 10032, USA.

Immigrant African gay and bisexual men (GBM) are at risk for substance use and adverse mental health outcomes due to negative experiences in home and host countries. Little is known about correlates of substance use and mental health outcomes in this population. We explored pre- and post-migratory factors associated with substance use and depression in recently migrated African GBM. Read More

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December 2018

Altered structural connectivity of the motor subnetwork in multiple system atrophy with cerebellar features.

Eur Radiol 2018 Dec 14. Epub 2018 Dec 14.

Symbiosis Center for Medical Image Analysis and Symbiosis Institute of Technology, Symbiosis International University, Lavale, Mulshi, Pune, Maharashtra, 412115, India.

Objectives: To investigate the structural connectivity of the motor subnetwork in multiple system atrophy with cerebellar features (MSA-C), a distinct subtype of MSA, characterized by predominant cerebellar symptoms.

Methods: Twenty-three patients with MSA-C and 25 age- and gender-matched healthy controls were recruited for the study. Disease severity was quantified using the Unified Multiple System Atrophy Rating Scale (UMSARS). Read More

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December 2018
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A novel role for E2F3b in regulating cocaine action in the prefrontal cortex.

Neuropsychopharmacology 2018 Dec 14. Epub 2018 Dec 14.

Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Drug abuse is a multifaceted disorder that involves maladaptive decision making. Long-lasting changes in the addicted brain are mediated by a complex circuit of brain reward regions. The prefrontal cortex (PFC) is one region in which chronic drug exposure changes expression and function of upstream transcriptional regulators to alter drug responses and aspects of the addicted phenotype. Read More

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December 2018

Sleep selectively stabilizes contextual aspects of negative memories.

Sci Rep 2018 Dec 14;8(1):17861. Epub 2018 Dec 14.

Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Sleep and emotion are both powerful modulators of the long-term stability of episodic memories, but precisely how these factors interact remains unresolved. We assessed changes in item recognition, contextual memory, and affective tone for negative and neutral memories across a 12 h interval containing sleep or wakefulness in 71 human volunteers. Our data indicate a sleep-dependent stabilization of negative contextual memories, in a way not seen for neutral memories, item recognition, or across wakefulness. Read More

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December 2018

Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression.

Transl Psychiatry 2018 Dec 14;8(1):280. Epub 2018 Dec 14.

Statistical Genomics and Data Analysis Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Growing evidence suggests that the glutamatergic modulator ketamine has rapid antidepressant effects in treatment-resistant depressed subjects. The anticholinergic agent scopolamine has also shown promise as a rapid-acting antidepressant. This study applied genome-wide markers to investigate the role of genetic variants in predicting acute antidepressant response to both agents. Read More

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December 2018

Hypoglycemic side effects of sulfonylureas and repaglinide in ageing patients - knowledge and self-management.

J Physiol Pharmacol 2018 Aug 9;69(4). Epub 2018 Dec 9.

Thuringia Clinic Saalfeld "Georgius Agricola", Department of Internal Medicine II, Division of Gastroenterology, Teaching Hospital of the University of Jena, Saalfeld/Saale, Germany.

Insulinotropic oral antidiabetics (OAD) such as sulfonylureas and (SU) glinides are among the frequently prescribed OAD. Side effects are the potential to induce hypoglycemias and weight gain. The aim was to assess the self-managing skills in case of a hypoglycemic event in an elderly type 2 diabetic patient population. Read More

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Effectiveness of cognitive-behavioural therapy: a protocol for an overview of systematic reviews and meta-analyses.

BMJ Open 2018 Dec 14;8(12):e025761. Epub 2018 Dec 14.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Introduction: Cognitive-behavioural therapy (CBT) is a psychological therapy that has been used to improve patient well-being across multiple mental and physical health problems. Its effectiveness has been examined in thousands of randomised control trials that have been synthesised into hundreds of systematic reviews. The aim of this overview is to map, synthesise and assess the reliability of evidence generated from these systematic reviews of the effectiveness of CBT across all health conditions, patient groups and settings. Read More

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December 2018

Association of postlunch napping duration and night-time sleep duration with cognitive impairment in Chinese elderly: a cross-sectional study.

BMJ Open 2018 Dec 14;8(12):e023188. Epub 2018 Dec 14.

Director Office, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.

Objective: To analyse the independent and combined associations of postlunch napping duration and night-time sleep duration with risk of cognitive impairment among Chinese elderly.

Design: A cross-sectional study.

Setting: We analysed the data from Zhejiang Ageing and Health Cohort, a population-based survey of seven counties located in Zhejiang province in eastern China. Read More

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December 2018

Cultural validation of the Addenbrooke's Cognitive Examination Version III Urdu for the British Urdu-speaking population: a qualitative assessment using cognitive interviewing.

BMJ Open 2018 Dec 14;8(12):e021057. Epub 2018 Dec 14.

Centre for Primary Care, The University of Manchester, Manchester, UK.

Objectives: Our research determined whether the Addenbrooke's Cognitive Examination Version III (ACE-III) Urdu eliminated cultural bias through a qualitative assessment of its understanding and acceptability within the British Urdu-speaking population, employing cognitive interviews.

Method: We aimed to recruit 25 participants fluent in speaking and writing Urdu, over the age of 60 years, able to give informed consent and who did not have a history of cognitive impairment. Participants were administered the ACE-III Urdu, and cognitive interviews were conducted, which involve obtaining verbal data on the individual's perception of the assessment overall, their understanding of the mental processes behind how they interpreted questions within the assessment and how they produced appropriate responses. Read More

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December 2018

Loss of adult 5-HT1A autoreceptors results in a paradoxical anxiogenic response to antidepressant treatment.

J Neurosci 2018 Dec 14. Epub 2018 Dec 14.

Ottawa Hospital Research Institute (Neuroscience), Ottawa, Canada

Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are first-line antidepressants, but require several weeks to elicit their actions. Chronic SSRI treatment induces desensitization of 5-HT1A autoreceptors to enhance 5-HT neurotransmission. Mice (both sexes) with gene deletion of 5-HT1A autoreceptors in adult 5-HT neurons (1AcKO) were tested for response to SSRIs. Read More

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December 2018

Efficacy of a Parent-Based, Indicated Prevention for Anorexia Nervosa: Randomized Controlled Trial.

J Med Internet Res 2018 Dec 14;20(12):e296. Epub 2018 Dec 14.

Department of Psychiatry, Stanford University School of Medicine, Stanford, CA, United States.

Background: Web-based preventive interventions can reduce risk and incidence of bulimia and binge eating disorders among young high-risk women. However, their specific effects on core symptoms of anorexia nervosa (AN) are rather weak.

Objective: The primary objective of this study was to evaluate the efficacy of an indicated, parent-based, Web-based preventive program Eltern als Therapeuten (E@T) in reducing risk factors and symptoms of AN. Read More

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December 2018

Examining Predictors of Real-World User Engagement with Self-Guided eHealth Interventions: Analysis of Mobile Apps and Websites Using a Novel Dataset.

J Med Internet Res 2018 Dec 14;20(12):e11491. Epub 2018 Dec 14.

Zucker Hillside Hospital, Glen Oaks, NY, United States.

Background: The literature suggests that the product design of self-guided electronic health (eHealth) interventions impacts user engagement. Traditional trial settings, however, do not enable the examination of these relationships in real-world use.

Objective: This study aimed to examine whether the qualities of product design, research evidence, and publicly available data predict real-world user engagement with mobile and Web-based self-guided eHealth interventions. Read More

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December 2018

Supported Internet-Delivered Cognitive Behavioral Therapy Programs for Depression, Anxiety, and Stress in University Students: Open, Non-Randomised Trial of Acceptability, Effectiveness, and Satisfaction.

JMIR Ment Health 2018 Dec 14;5(4):e11467. Epub 2018 Dec 14.

Department of Psychology, University of Minnesota, Minneapolis, MN, United States.

Background: Many university campuses have limited mental health services that cannot cope with the high demand. One alternative is to use internet-delivered cognitive behavioral therapy (iCBT) as a way of tackling barriers such as lack of availability and scheduling issues.

Objective: This study aimed to assess feasibility, acceptability, effectiveness, and satisfaction of a supported iCBT intervention offering 3 programs on depression, anxiety, and stress to university students. Read More

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December 2018

White matter organization in developmental coordination disorder: A pilot study exploring the added value of constrained spherical deconvolution.

Neuroimage Clin 2018 Dec 3. Epub 2018 Dec 3.

Mary MacKillop Institute for Health Research, Faculty of Health Sciences, Australian Catholic University, Melbourne, Australia.

Previous studies of white matter organization in sensorimotor tracts in developmental coordination disorder (DCD) have adopted diffusion tensor imaging (DTI), a method unable to reconcile pathways with 'crossing fibres'. In response to limitations of the commonly adopted DTI approach, the present study employed a framework that can reconcile the 'crossing fibre' problem (i.e. Read More

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December 2018

The influence of mental health on Patient-Reported Outcomes Measurement Information System (PROMIS) and traditional outcome instruments in patients with symptomatic glenohumeral arthritis.

J Shoulder Elbow Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Orthopaedic Surgery, Washington University in St Louis, St Louis, MO, USA.

Background: The Patient-Reported Outcomes Measurement Information System (PROMIS) assessment includes computerized adaptive tests (CATs) that assess function, pain, depression, and anxiety. The influence of mental health on patients' self-reported pain and function has not been explored using PROMIS in patients with symptomatic glenohumeral osteoarthritis.

Methods: This cross-sectional study included 284 shoulders in 276 patients presenting with isolated glenohumeral osteoarthritis. Read More

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December 2018

Malaria, mental disorders, immunity and their inter-relationships - A cross sectional study in a household population in a health and demographic surveillance site in Kenya.

EBioMedicine 2018 Dec 6. Epub 2018 Dec 6.

Kenya Medical Research Institute, Kenya.

Background: Both malaria and mental disorders are associated with immune changes. We have previously reported the associations between malaria and mental disorders. We now report associations between malaria, mental disorders and immunity. Read More

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December 2018

Sexual identity and mental health in young people: an opportunity to reduce health inequity.

Lancet Child Adolesc Health 2018 Dec 11. Epub 2018 Dec 11.

Centre for Adolescent Health, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, VIC 3052, Australia; Department of Paediatrics, University of Melbourne, VIC, Australia; Department of Obstetrics and Gynaecology, Royal Women's Hospital and University of Melbourne, Melbourne, VIC, Australia.

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December 2018

Depression and self-harm from adolescence to young adulthood in sexual minorities compared with heterosexuals in the UK: a population-based cohort study.

Lancet Child Adolesc Health 2018 Dec 11. Epub 2018 Dec 11.

Division of Psychiatry, Faculty of Brain Sciences, University College London, London, UK. Electronic address:

Background: There are few population-based cohort studies of the emergence, development, and persistence of mental health problems in sexual minorities compared with heterosexuals. We compared trajectories of depressive symptoms in sexual-minority adolescents and heterosexual adolescents from when they were aged 10 years to 21 years, and examined self-harm at ages 16 years and 21 years.

Methods: The study included 4828 adolescents born between April 1, 1991, and Dec 31, 1992, from the Avon Longitudinal Study of Parents and Children birth cohort (Bristol, UK) who reported their sexual orientation when aged 16 years. Read More

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December 2018

Patient and provider characteristics associated with communication about opioids: An observational study.

Patient Educ Couns 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Regenstrief Institute, Inc., Indianapolis, IN, USA; Department of Communication Studies, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA; Center for Health Information and Communication, Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA.

Objective: Our objective is to examine the relationship of patient and provider characteristics and communication with chronic non-cancer pain and opioid management in primary care.

Method: We conducted an observational study using audio-recorded primary care appointments (up to 3/patient) and self-reported assessments of primary care providers (PCPs) and patients. We coded visit transcripts for 1) opioid and pain management talk and 2) mental health and opioid safety talk. Read More

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December 2018

Off-hours use of a smartphone intervention to extend support for individuals with schizophrenia spectrum disorders recently discharged from a psychiatric hospital.

Schizophr Res 2018 Dec 11. Epub 2018 Dec 11.

The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Blvd, Hempstead, NY 11549, USA; Feinstein Institute for Medical Research, 350 Community Dr, Manhasset, NY 11030, USA.; Department of Psychiatry, Hofstra Northwell School of Medicine, 500 Hofstra Blvd, Hempstead, NY 11549, USA.. Electronic address:

Introduction: Technology-delivered healthcare interventions may enhance dissemination of evidence-based treatments in low-resource areas. These interventions may be accessed 'on-demand,' including after hours. Patients with schizophrenia do engage with technological aids but when/how they would utilize these tools is not known. Read More

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December 2018
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