157 results match your criteria Mental Disorders Secondary to General Medical Conditions


The Prevalence of patients with panic attacks (PAs) and panic disorder (PD) visiting Emergency Departments of the Verona Hospital.

Ann Ig 2019 Mar-Apr;31(2):93-108

Specialization School in Hygiene and Preventive Medicine, University of Verona, Italy.

Background: Panic Attacks (PAs) and Panic Disorder (PD) represent a heavy burden not only because of the difficulty in distinguishing them from other pathologies and in treating them appropriately but also because of their impact on public health worldwide. In Europe, PD constitutes one of the five most common mental disorders adversely affecting quality of life.

Study Design: The aim of this study is to evaluate the period prevalence of visits to the Emergency Departments of the University Hospital of Verona (North East of Italy) over the period between 2012-2016 because of symptoms of PAs or PD in order to quantify the burden of the disorder. Read More

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http://dx.doi.org/10.7416/ai.2019.2262DOI Listing
February 2019
2 Reads

A randomized controlled trial of the compuLsive Exercise Activity TheraPy (LEAP): A new approach to compulsive exercise in anorexia nervosa.

Int J Eat Disord 2018 Aug 26;51(8):999-1004. Epub 2018 Jul 26.

Discipline of Behavioural Psychology, WMG and Warwick Medical School, University of Warwick, Coventry, United Kingdom.

Objective: To compare the efficacy of the compuLsive Exercise Activity theraPy (LEAP) programme integrated with manualized cognitive behavioral therapy for anorexia nervosa (CBT-AN) compared to CBT-AN alone.

Method: Seventy-eight adults were randomized to CBT-AN, delivered with or without eight embedded sessions of LEAP, for a total of 34 individual outpatient sessions. Participants were assessed at baseline, the end of the first phase of CBT-AN (which included LEAP), mid-therapy, end of therapy, and at 3 and 6 months follow-up. Read More

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http://dx.doi.org/10.1002/eat.22920DOI Listing
August 2018
11 Reads

Interim buprenorphine treatment during delays to comprehensive treatment: Changes in psychiatric symptoms.

Exp Clin Psychopharmacol 2018 08 25;26(4):403-409. Epub 2018 Jun 25.

Vermont Center on Behavior and Health.

Prevalence of depression, anxiety, and mood disorders among individuals with opioid use disorder far exceeds that of the general population. While psychiatric symptoms often improve upon entry into opioid treatment, this has typically been seen with treatments involving psychosocial counseling. In this secondary analysis, we examined changes in psychiatric symptoms during a randomized clinical trial evaluating an interim buprenorphine treatment without counseling among individuals awaiting entry into comprehensive treatment. Read More

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http://dx.doi.org/10.1037/pha0000199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072576PMC
August 2018
24 Reads

Antidepressants for the treatment of depression in people with cancer.

Cochrane Database Syst Rev 2018 04 23;4:CD011006. Epub 2018 Apr 23.

​Department of Neuroscience, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Policlinico "GB Rossi", Piazzale L.A. Scuro, 10, Verona, Italy, 37134.

Background: Major depression and other depressive conditions are common in people with cancer. These conditions are not easily detectable in clinical practice, due to the overlap between medical and psychiatric symptoms, as described by diagnostic manuals such as the Diagnostic and Statistical Manual of Mental Disorders (DSM) and International Classification of Diseases (ICD). Moreover, it is particularly challenging to distinguish between pathological and normal reactions to such a severe illness. Read More

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http://dx.doi.org/10.1002/14651858.CD011006.pub3DOI Listing
April 2018
5 Reads

Health Services Use and Costs for Americans With Intellectual and Developmental Disabilities: A National Analysis.

Intellect Dev Disabil 2018 04;56(2):101-118

Glenn T. Fujiura, University of Illinois, Chicago; Henan Li, Brandeis University, and Sandy Magaña, University of Texas.

Health services and associated costs for adults with intellectual and developmental disabilities (IDD) were nationally profiled and the predictors of high expense users statistically modeled. Using linked data from the National Health Interview Survey and Medical Expenditure Panel Survey for the years 2002 through 2011, the study found a mixed pattern of differences in rates of service use and costs when compared to the general population depending upon personal characteristics, health status, and type of health care service. Prescription medication costs were the primary driver of total health care expenditures for Americans with IDD. Read More

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http://dx.doi.org/10.1352/1934-9556-56.2.101DOI Listing
April 2018
6 Reads

Efficacy and cost-effectiveness of a blended cognitive behavioral therapy for depression in Spanish primary health care: study protocol for a randomised non-inferiority trial.

BMC Psychiatry 2018 03 23;18(1):74. Epub 2018 Mar 23.

Department of Basic Psychology, Clinical and Psychobiology, Jaume I University, Castellón, Spain.

Background: Data from primary health care in Spain show a high prevalence of the major depressive disorder. Blended treatment (combination of face-to-face and online components) seems to be a very promising tool for the optimization and dissemination of psychological treatments in a cost-effective form. Although there is growing data that confirm the advantages of blended therapies, few studies have analyzed their application in regular clinical practice. Read More

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http://dx.doi.org/10.1186/s12888-018-1638-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865366PMC
March 2018
12 Reads

Prevalence of and characteristics associated with insomnia and obstructive sleep apnea among veterans with knee and hip osteoarthritis.

BMC Musculoskelet Disord 2018 03 9;19(1):79. Epub 2018 Mar 9.

Durham VA Health Care System, VA Medical Center (152), 508 Fulton Street, Durham, NC, 27705, USA.

Background: Few studies have examined patterns of specific sleep problems among individuals with osteoarthritis (OA). The primary objective of this study was to examine prevalence of symptoms of insomnia and obstructive sleep apnea (OSA) among Veterans with OA. Secondary objectives were to assess proportions of individuals with insomnia and OSA symptoms who may have been undiagnosed and to examine Veterans' characteristics associated with insomnia and OSA symptoms. Read More

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http://dx.doi.org/10.1186/s12891-018-1993-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845198PMC
March 2018
10 Reads

Catatonic Stupor in Schizophrenic Disorders and Subsequent Medical Complications and Mortality.

Psychosom Med 2018 May;80(4):370-376

From the Department of Neuropsychiatry (Funayama, Takata, Koreki, Ogino), Ashikaga Red Cross Hospital, Tochigi; and Department of Neuropsychiatry (Mimura), Keio University School of Medicine, Tokyo, Japan.

Objective: Although catatonia can occur secondary to a general medical condition, catatonia itself has been known to lead to various medical compolications. Although case reports on the association of catatonia with subsequent medical complications have been documented, no comprehensive large-scale study has been performed. To investigate specific medical complications after catatonia, we conducted a retrospective cohort study of specific medical complications of schizophrenia patients with catatonia. Read More

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http://dx.doi.org/10.1097/PSY.0000000000000574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959200PMC
May 2018
7 Reads

Prevalence of physical conditions and multimorbidity in a cohort of adults with intellectual disabilities with and without Down syndrome: cross-sectional study.

BMJ Open 2018 02 5;8(2):e018292. Epub 2018 Feb 5.

Mental Health and Wellbeing Research Group, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.

Objectives: To investigate the prevalence of multimorbidity in adults with intellectual disabilities with and without Down syndrome.

Design: Large, population-based cross-sectional study.

Setting: The geographical area of one Health Board, Scotland. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-018292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829598PMC
February 2018
6 Reads

Pharmacotherapy for primary delusional jealousy, a retrospective observational study of 32 cases with Othello syndrome.

Int Clin Psychopharmacol 2018 03;33(2):92-97

Department of Psychiatry, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.

To determine whether primary delusional jealousy can be treated effectively with antipsychotics or antidepressants, and whether any clinical variables are associated with response to pharmacotherapy, we carried out a retrospective case series observational study by reviewing clinical records of patients with an International Classification of Disease, 9th ed., diagnostic code of 297 (delusional disorders) who were treated at the Department of Psychiatry of a university affiliated hospital from January 2010 to December 2015. Only those records showing obvious delusional jealousy not secondary to other medical conditions, dementia, or schizophrenia were scrutinized thoroughly with respect to types of pharmacotherapy, treatment response, and other demographic and clinical variables likely to be associated with clinical outcomes. Read More

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http://dx.doi.org/10.1097/YIC.0000000000000207DOI Listing
March 2018
2 Reads

Defending psychiatry or defending the trivial effects of therapeutic interventions? A citation content analysis of an influential paper.

Epidemiol Psychiatr Sci 2018 06 29;27(3):230-239. Epub 2017 Nov 29.

Meta-Research Innovation Center at Stanford (METRICS),Stanford University,Palo Alto,USA.

Aims: Leucht et al. in 2012 described an overview of meta-analyses of the efficacy of medication in psychiatry and general medicine, concluding that psychiatric drugs were not less efficacious than other drugs. Our goal was to explore the dissemination of this highly cited paper, which combined a thought provoking message with a series of caveats. Read More

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https://www.cambridge.org/core/product/identifier/S204579601
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http://dx.doi.org/10.1017/S2045796017000750DOI Listing
June 2018
1 Read

Effectiveness of SBIRT for Alcohol Use Disorders in the Emergency Department: A Systematic Review.

West J Emerg Med 2017 Oct 21;18(6):1143-1152. Epub 2017 Sep 21.

Massachusetts General Hospital, Department of Emergency Medicine, Boston, Massachusetts.

Introduction: Alcohol use disorders (AUD) place a significant burden on individuals and society. The emergency department (ED) offers a unique opportunity to address AUD with brief screening tools and early intervention. We undertook a systematic review of the effectiveness of ED brief interventions for patients identified through screening who are at risk for AUD, and the effectiveness of these interventions at reducing alcohol intake and preventing alcohol-related injuries. Read More

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http://dx.doi.org/10.5811/westjem.2017.7.34373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654886PMC
October 2017
18 Reads

Change in psychotropic drug use in Norwegian nursing homes between 2004 and 2011.

Int Psychogeriatr 2018 03 9;30(3):385-394. Epub 2017 Oct 9.

Department of General Practice and Elderly Care Medicine,University of Groningen,University Medical Centre Groningen,Groningen,the Netherlands.

ABSTRACTBackground:We aimed to assess whether there were any changes in the use of psychotropic drugs in Norwegian nursing homes between 2004 and 2011. Also, we investigated whether the predictors of use of specific psychotropic drug groups have changed.

Methods: We conducted a secondary analysis of two cohort studies of two Norwegian nursing home samples (2004/05 and 2010/11). Read More

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http://dx.doi.org/10.1017/S1041610217001788DOI Listing

Nocturia is Associated with Poor Sleep Quality Among Older Women in the Study of Osteoporotic Fractures.

J Am Geriatr Soc 2017 Nov 15;65(11):2502-2509. Epub 2017 Sep 15.

California Pacific Medical Center, San Francisco, California.

Objectives: (1) To examine relationships between frequency of nocturia and self-reported sleep quality and objective sleep measures in older women, and (2) to estimate the amount of variation in sleep measures that is specifically attributable to frequency of nocturia.

Design And Setting: Secondary, cross sectional analysis of the multicenter prospective cohort Study of Osteoporotic Fractures (SOF).

Participants: Community-dwelling women aged ≥80 years. Read More

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http://dx.doi.org/10.1111/jgs.15027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681421PMC
November 2017
16 Reads

Daytime sleepiness: more than just Obstructive Sleep Apnea (OSA).

Med Lav 2017 08 28;108(4):260-266. Epub 2017 Aug 28.

IRCCS San Raffaele Scientific Institute, Department of Clinical Neurosciences and Università Vita-Salute San Raffaele, Milan, Italy.

Excessive Daytime Sleepiness (EDS) is a common condition with a significant impact on quality of life and general health. A mild form of sleepiness can be associated with reduced reactivity and modest distractibility symptoms, but more severe symptomatic forms are characterized by an overwhelming and uncontrollable need to sleep, causing sudden sleep attacks, amnesia and automatic behaviors. The prevalence in the general population is between 10 and 25%. Read More

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http://dx.doi.org/10.23749/mdl.v108i4.6497DOI Listing
August 2017
13 Reads

A prospective cohort study of hospital separations among people who inject drugs in Australia: 2008-2013.

BMJ Open 2017 Aug 18;7(8):e014854. Epub 2017 Aug 18.

Centre for Population Health, Burnet Institute, Melbourne, Victoria, Australia.

Objectives: Injecting drug use is a persistent behaviour that increases the risk of morbidities and mortality. We assessed the burden of hospital separations among people who inject drugs (PWID), the excess compared to the general population and characteristics of separations associated with frequent use.

Design: Prospective cohort study. Read More

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http://dx.doi.org/10.1136/bmjopen-2016-014854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724200PMC
August 2017
8 Reads

Scope, Scale, and Dose of the World's Largest School-Based Mental Health Programs.

Harv Rev Psychiatry 2017 Sep/Oct;25(5):218-228

From: Harvard Medical School (Drs. Murphy and Jellinek); Departments of Psychiatry (Dr. Murphy) and Pediatrics (Dr. Jellinek), Massachusetts General Hospital, Boston, MA; Clinical Child Psychology Program, University of Kansas (Ms. Abel); Department of Psychiatry, University of Maryland School of Medicine (Dr. Hoover); Department of Psychiatry, Oxford University, Warneford Hospital, Oxford, UK (Dr. Fazel).

Untreated mental health problems are among the most disabling, persistent, and costly health conditions. Because they often begin in childhood and continue into adulthood, there has been growing interest in preventive mental health programs for children. In recent years, several such programs have been implemented at regional, state, or national scale, and although many experimental studies have documented positive outcomes of individual programs, this article represents the first attempt to systematically compare the largest programs in terms of scope, scale, and dose. Read More

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http://dx.doi.org/10.1097/HRP.0000000000000149DOI Listing
May 2018
5 Reads

Lithium Use in Pregnancy and the Risk of Cardiac Malformations.

N Engl J Med 2017 06;376(23):2245-2254

From the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine (E.P., K.F.H., B.T.B., R.J.D., H.M.), and the Department of Anesthesiology, Perioperative and Pain Medicine (B.T.B.), Brigham and Women's Hospital and Harvard Medical School, the Department of Epidemiology, Harvard T.H. Chan School of Public Health (J.M.C., S.H.-D.), and the Center for Women's Mental Health, Department of Psychiatry, Massachusetts General Hospital (L.S.C.) - all in Boston.

Background: There has been concern that exposure to lithium early in pregnancy may be associated with a marked increase in the risk of Ebstein's anomaly (a right ventricular outflow tract obstruction defect) in infants and overall congenital cardiac defects, but data are conflicting and limited.

Methods: We conducted a cohort study involving 1,325,563 pregnancies in women who were enrolled in Medicaid and who delivered a live-born infant between 2000 and 2010. We examined the risk of cardiac malformations among infants exposed to lithium during the first trimester as compared with unexposed infants and, in secondary analyses, with infants exposed to another commonly used mood stabilizer, lamotrigine. Read More

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http://dx.doi.org/10.1056/NEJMoa1612222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667676PMC
June 2017
28 Reads

Hypertension with unsatisfactory sleep health (HUSH): study protocol for a randomized controlled trial.

Trials 2017 06 6;18(1):256. Epub 2017 Jun 6.

Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, E-1123 TDH, Pittsburgh, PA, 15213, USA.

Background: Insomnia is common in primary care medical practices. Although behavioral treatments for insomnia are safe, efficacious, and recommended in practice guidelines, they are not widely-available, and their effects on comorbid medical conditions remain uncertain. We are conducting a pragmatic clinical trial to test the efficacy of two cognitive behavioral treatments for insomnia (Brief Behavioral Treatment for Insomnia (BBTI) and Sleep Healthy Using the Internet (SHUTi)) versus an enhanced usual care condition (EUC). Read More

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http://dx.doi.org/10.1186/s13063-017-2001-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461741PMC
June 2017
40 Reads

Current use of chromosomal microarray by Australian paediatricians and implications for the implementation of next generation sequencing.

J Paediatr Child Health 2017 Jul 27;53(7):650-656. Epub 2017 Apr 27.

Department of General Medicine, Royal Children's Hospital, Melbourne, Victoria, Australia.

Aim: Chromosomal microarray (CMA) is an important diagnostic test for children with multiple congenital anomalies or certain developmental behavioural problems suggestive of an underlying genetic diagnosis. However, there are medical and ethical complexities to its use and few Australian policies to guide practice. We aimed to describe the current practice of Australian paediatricians in relation to CMA testing. Read More

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http://dx.doi.org/10.1111/jpc.13523DOI Listing
July 2017
4 Reads

The effectiveness of creating an online life story book on persons with early dementia and their informal caregivers: a protocol of a randomized controlled trial.

BMC Geriatr 2017 Apr 21;17(1):95. Epub 2017 Apr 21.

Department of Psychology, Health and Technology, University of Twente, P.O. Box 217, 7500, AE, Enschede, The Netherlands.

Background: Dementia has a high burden for patients, informal caregivers and society. Given changes in care systems, more persons with dementia will live longer at home. However, living at home (with dementia) with a good quality of life is not easy to achieve. Read More

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http://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-
Publisher Site
http://dx.doi.org/10.1186/s12877-017-0471-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399324PMC
April 2017
16 Reads

Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders.

J Neurol Neurosurg Psychiatry 2017 06 17;88(6):491-497. Epub 2017 Apr 17.

Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

Objective: Adverse early-life events are predisposing factors for functional neurological disorder (FND) and post-traumatic stress disorder (PTSD). Cingulo-insular regions are implicated in the biology of both conditions and are sites of stress-mediated neuroplasticity. We hypothesised that functional neurological symptoms and the magnitude of childhood abuse would be associated with overlapping anterior cingulate cortex (ACC) and insular volumetric reductions, and that FND and PTSD symptoms would map onto distinct cingulo-insular areas. Read More

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http://dx.doi.org/10.1136/jnnp-2016-314998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497745PMC
June 2017
31 Reads

Investigating Clinical Benefits of a Novel Sleep-Focused Mind-Body Program on Gulf War Illness Symptoms: A Randomized Controlled Trial.

Psychosom Med 2017 Jul/Aug;79(6):706-718

From the Pain Research Center (Nakamura, Lipschitz, Donaldson, Kida, Williams), Department of Anesthesiology, University of Utah School of Medicine, Salt Lake City, Utah; College of Social Work (Landward), University of Utah, Salt Lake City, Utah; Integrative Health (Glover), Division of Holistic Health, VA Medical Center, Salt Lake City, Utah; and VA Medical Center and University of Utah (West, Tuteja), Salt Lake City, Utah.

Objective: Mind-Body Bridging (MBB) has been shown to be effective for improving disturbed sleep. In this prospective randomized controlled trial, we evaluated the efficacy of sleep-focused MBB compared with sleep education control (SED) for improving sleep in previously deployed Gulf War veterans.

Methods: US military service members with sleep and physical health complaints who were deployed in 1990-1991 were randomized to receive three weekly sessions of either MBB (n = 33) or SED (n = 27) between 2012 and 2015. Read More

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http://Insights.ovid.com/crossref?an=00006842-201707000-0001
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http://dx.doi.org/10.1097/PSY.0000000000000469DOI Listing
April 2018
11 Reads

Vestibular stimulation improves insight into illness in schizophrenia spectrum disorders.

Psychiatry Res 2017 05 13;251:333-341. Epub 2017 Feb 13.

Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction & Mental Health, Toronto, Ontario, Canada; Geriatric Mental Health Program, Centre for Addiction & Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Campbell Mental Health Research Institute, Research Program, Centre for Addiction & Mental Health, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

Impaired insight into illness (IMP-INS) is common among individuals with schizophrenia spectrum disorders (SSD), contributing to medication nonadherence and poor clinical outcomes. Caloric vestibular simulation (CVS) is typically used to assess peripheral vestibular system function. Left cold CVS is also a transiently effective treatment for IMP-INS and hemineglect secondary to right brain hemisphere stroke, and possibly for IMP-INS and mood stabilization in patients with SSD. Read More

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http://dx.doi.org/10.1016/j.psychres.2017.02.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720160PMC
May 2017
20 Reads

Primary health care for people with an intellectual disability: an exploration of consultations, problems identified, and their management in Australia.

J Intellect Disabil Res 2017 05 24;61(5):399-410. Epub 2017 Jan 24.

Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW, Australia.

Background: People with an intellectual disability (ID) have more complex and different patterns of health care needs than the general population. They experience a greater burden of multi-morbidity, high levels of undetected and unmanaged health issues, and premature mortality than the general population. Primary care has a key role in the health care of people with an ID. Read More

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http://dx.doi.org/10.1111/jir.12352DOI Listing
May 2017
4 Reads

Suspected Delirium Predicts the Thoroughness of Catatonia Evaluation.

J Neuropsychiatry Clin Neurosci 2017 30;29(2):148-154. Epub 2016 Nov 30.

From the Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (JRL, KCJ, JJC); and the Menninger Clinic, Houston, TX (MJC).

Although commonly linked to psychiatric disorders, catatonia is frequently identified secondary to neurological and general medical conditions (GMCs). The present study aimed to characterize the diagnostic workup of cases of catatonia in a general hospital setting. The authors performed a retrospective chart review of 54 cases of catatonia, over 3 years. Read More

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http://dx.doi.org/10.1176/appi.neuropsych.15090230DOI Listing
August 2017
13 Reads

Effect of ω-3 Polyunsaturated Fatty Acids in Young People at Ultrahigh Risk for Psychotic Disorders: The NEURAPRO Randomized Clinical Trial.

JAMA Psychiatry 2017 Jan;74(1):19-27

Orygen, National Centre of Excellence in Youth Mental Health, Melbourne, Australia2Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia3Department of Psychiatry, Medical University of Vienna, Vienna, Austria.

Importance: A promising treatment to prevent onset and improve outcomes in patients at ultrahigh risk for psychosis is dietary supplementation with long-chain ω-3 polyunsaturated fatty acids (PUFAs).

Objective: To determine whether treatment with ω-3 PUFAs in combination with a high-quality psychosocial intervention (cognitive behavioral case management [CBCM]) is more effective than placebo plus CBCM.

Design, Setting, And Participants: NEURAPRO, a double-blind, placebo-controlled, randomized clinical trial, was conducted from March 1, 2010, to September 30, 2014, in 10 specialized early psychosis treatment services in Australia, Asia, and Europe. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2016.2902DOI Listing
January 2017
32 Reads

Rationale and protocol for using a smartphone application to study autism spectrum disorders: SMARTAUTISM.

BMJ Open 2016 11 22;6(11):e012135. Epub 2016 Nov 22.

Resource Center for Autism (CRA) Loire Valley, CHU Angers, Angers, France.

Introduction: Longitudinal studies on the evolution of autism spectrum disorder (ASD) symptoms are limited and have primarily used repeated measurements performed several months apart. However, measurements of changes in everyday life should more closely reflect the 'real life' of the patient and his or her family. We propose to study the child's ASD symptoms and their effect on the quality of life, psychological status and anxiety of the child's parents over a 6-month period using SMARTAUTISM, a smartphone application. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2016-01213
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2016-012135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128902PMC
November 2016
27 Reads

Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia.

Mol Psychiatry 2016 12 11;21(12):1680-1689. Epub 2016 Oct 11.

Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.

Schizophrenia is a devastating neurodevelopmental disorder with a complex genetic etiology. Widespread cortical gray matter loss has been observed in patients and prodromal samples. However, it remains unresolved whether schizophrenia-associated cortical structure variations arise due to disease etiology or secondary to the illness. Read More

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http://www.nature.com/articles/mp2016164
Publisher Site
http://dx.doi.org/10.1038/mp.2016.164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144575PMC
December 2016
11 Reads

Telephone-Delivered Stepped Collaborative Care for Treating Anxiety in Primary Care: A Randomized Controlled Trial.

J Gen Intern Med 2017 Mar 6;32(3):245-255. Epub 2016 Oct 6.

Department of Psychiatry, Weill Cornell Medical College, White Plains, NY, USA.

Background: Collaborative care for depression is more effective in improving treatment outcomes than primary care physicians' (PCPs) usual care (UC). However, few trials of collaborative care have targeted anxiety.

Objective: To examine the impact and 12-month durability of a centralized, telephone-delivered, stepped collaborative care intervention (CC) for treating anxiety disorders across a network of primary care practices. Read More

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http://dx.doi.org/10.1007/s11606-016-3873-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330997PMC
March 2017
19 Reads

Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies.

J Clin Endocrinol Metab 2016 12 30;101(12):4945-4954. Epub 2016 Sep 30.

Department of General Internal Medicine (C.R., D.S., C.E.A., C.B., D.A., N.R.), Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland; Institute of Primary Health Care (BIHAM), Faculty of Medicine (B.R.d.C., N.R.), University of Bern, 3012 Bern, Switzerland; Service of Endocrinology, Diabetes and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; University of Cambridge Metabolic Research Laboratories (T.-H.C.), Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Department of Epidemiology (L.C., R.P.P.), Rotterdam Thyroid Center, 3015 GE Rotterdam, The Netherlands; School of Psychiatry and Clinical Neurosciences (O.P.A.), University of Western Australia, Perth 6009, Australia; School of Sport, Exercise and Health Sciences (E.H.), Loughborough University, Loughborough LE11 3TU, United Kingdom; Department of Cardiology (S.T.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Kuakini Medical Center and the Department of Geriatric Medicine (K.M.), John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96817; Department of Gerontology and Geriatrics (S.P.M.), Leiden University Medical Center, Leiden and Institute for Evidence-based Medicine in Old Age (IEMO), 2333 ZA Leiden, The Netherlands; Department of Public Health and Primary Care (J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; and Department of Medicine (D.C.B.), University of California-San Francisco, San Francisco California 94143.

Context: Although both overt hyper- and hypothyroidism are known to lead to cognitive impairment, data on the association between subclinical thyroid dysfunction and cognitive function are conflicting.

Objective: This study sought to determine the risk of dementia and cognitive decline associated with subclinical thyroid dysfunction among prospective cohorts.

Data Sources: We searched in MEDLINE and EMBASE from inception until November 2014. Read More

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http://dx.doi.org/10.1210/jc.2016-2129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287525PMC
December 2016
32 Reads

Visual height intolerance and acrophobia: distressing partners for life.

J Neurol 2016 Oct 6;263(10):1946-53. Epub 2016 Jul 6.

Institute for Clinical Neurosciences and German Dizziness Center, Ludwig-Maximilians University, Munich, Germany.

The course of illness, the degree of social impairment, and the rate of help-seeking behavior was evaluated in a sample of individuals with visual height intolerance (vHI) and acrophobia. On the basis of a previously described epidemiological sample representative of the German general population, 574 individuals with vHI were identified, 128 fulfilled the DSM-5 diagnostic criteria of acrophobia. The illness of the majority of all susceptible individuals with vHI ran a year-long chronic course. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037147PMC
http://dx.doi.org/10.1007/s00415-016-8218-9DOI Listing
October 2016
41 Reads

[Epidemiological study of prevalence and risk factors for dental erosions among Polish young adults].

Pol Merkur Lekarski 2016 May;40(239):308-13

Medical University of Warsaw, Poland: Department of Comprehensive Dental Care.

Unlabelled: Dental erosion for many years has been a pathology of secondary interest to dental public health authorities, but this point of view is changing. In recent years the occurrence and severity of erosive tooth wear seems to have increased. Various studies have shown that the prevalence of erosive tooth wear has particularly increased among younger population. Read More

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May 2016
7 Reads

Vitamin D and Autism Spectrum Disorder: A Literature Review.

Nutrients 2016 Apr 21;8(4):236. Epub 2016 Apr 21.

Institute of Food Science and Technology-School of Food and Nutrition, Massey University, Palmerston North 4474, New Zealand.

Low vitamin D status in early development has been hypothesised as an environmental risk factor for Autism Spectrum Disorder (ASD), given the concurrent increase in the prevalence of these two conditions, and the association of vitamin D with many ASD-associated medical conditions. Identification of vitamin D-ASD factors may provide indications for primary and secondary prevention interventions. We systematically reviewed the literature for studies on vitamin D-ASD relationship, including potential mechanistic pathways. Read More

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https://pdfs.semanticscholar.org/3716/f07364b4e0cd9f9be37a80
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http://dx.doi.org/10.3390/nu8040236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848704PMC
April 2016
22 Reads
7 Citations
3.150 Impact Factor

REMCARE: Pragmatic Multi-Centre Randomised Trial of Reminiscence Groups for People with Dementia and their Family Carers: Effectiveness and Economic Analysis.

PLoS One 2016 19;11(4):e0152843. Epub 2016 Apr 19.

West Wales Organisation for Rigorous Trials in Health, Centre for Health Information Research and Evaluation, Swansea University, Swansea, United Kingdom.

Background: Joint reminiscence groups, involving people with dementia and family carers together, are popular, but the evidence-base is limited. This study aimed to assess the effectiveness and cost-effectiveness of joint reminiscence groups as compared to usual care.

Methods: This multi-centre, pragmatic randomised controlled trial had two parallel arms: intervention group and usual-care control group. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152843PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836678PMC
August 2016
38 Reads

How Does Sex Influence Multimorbidity? Secondary Analysis of a Large Nationally Representative Dataset.

Int J Environ Res Public Health 2016 Mar 31;13(4):391. Epub 2016 Mar 31.

General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland G12 9LX, UK.

Multimorbidity increases with age and is generally more common in women, but little is known about sex effects on the "typology" of multimorbidity. We have characterized multimorbidity in a large nationally representative primary care dataset in terms of sex in ten year age groups from 25 years to 75 years and over, in a cross-sectional analysis of multimorbidity type (physical-only, mental-only, mixed physical and mental; and commonest conditions) for 1,272,685 adults in Scotland. Our results show that women had more multimorbidity overall in every age group, which was most pronounced in the 45-54 years age group (women 26. Read More

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http://dx.doi.org/10.3390/ijerph13040391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847053PMC
March 2016
31 Reads

[Medical services for dementia in the Comprehensive Strategy to Accelerate Dementia Measures (New Orange Plan)].

Authors:
Shuichi Awata

Nihon Rinsho 2016 Mar;74(3):499-504

The way to provide medical services for dementia was reviewed in the context of the Comprehensive Strategy to Accelerate Dementia Measures (New Orange Plan). The basic structure of service providing system consists of the primary and secondary care services. Both are expected to function in the context of the community-based integrated care system. Read More

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March 2016
3 Reads

Impact of Collaborative Care for Underserved Patients with PTSD in Primary Care: a Randomized Controlled Trial.

J Gen Intern Med 2016 May 5;31(5):509-17. Epub 2016 Feb 5.

Clinical Directors Network (CDN), New York, NY, USA.

Background: The effectiveness of collaborative care of mental health problems is clear for depression and growing but mixed for anxiety disorders, including posttraumatic stress disorder (PTSD). We know little about whether collaborative care can be effective in settings that serve low-income patients such as Federally Qualified Health Centers (FQHCs).

Objective: We compared the effectiveness of minimally enhanced usual care (MEU) versus collaborative care for PTSD with a care manager (PCM). Read More

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http://dx.doi.org/10.1007/s11606-016-3588-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835392PMC
May 2016
11 Reads

Bipolar CHOICE (Clinical Health Outcomes Initiative in Comparative Effectiveness): a pragmatic 6-month trial of lithium versus quetiapine for bipolar disorder.

J Clin Psychiatry 2016 Jan;77(1):90-9

Massachusetts General Hospital, 50 Staniford St, Ste 580, Boston, MA 02114

Background: Bipolar disorder is among the 10 most disabling medical conditions worldwide. While lithium has been used extensively for bipolar disorder since the 1970s, second-generation antipsychotics (SGAs) have supplanted lithium since 1998. To date, no randomized comparative-effectiveness study has compared lithium and any SGA. Read More

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http://dx.doi.org/10.4088/JCP.14m09349DOI Listing
January 2016
70 Reads
5.498 Impact Factor

Association of Mental Disorders With Subsequent Chronic Physical Conditions: World Mental Health Surveys From 17 Countries.

JAMA Psychiatry 2016 Feb;73(2):150-8

Department of Health Care Policy, Harvard University Medical School, Boston, Massachusetts.

Importance: It is clear that mental disorders in treatment settings are associated with a higher incidence of chronic physical conditions, but whether this is true of mental disorders in the community, and how generalized (across a range of physical health outcomes) these associations are, is less clear. This information has important implications for mental health care and the primary prevention of chronic physical disease.

Objective: To investigate associations of 16 temporally prior DSM-IV mental disorders with the subsequent onset or diagnosis of 10 chronic physical conditions. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2015.2688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333921PMC
February 2016
19 Reads

Pain Interference and Incident Medical Disorders in the General Population.

Pain Med 2017 Jul;18(7):1209-1217

Department of Psychiatry.

Objective: To investigate the longitudinal relationship between pain interference and incident general medical conditions in a nationally representative sample.

Methods: Secondary data analysis comprising chi-square tests and binomial logistic regression analyses were performed on data obtained from the US National Epidemiologic Survey on Alcohol and Related Conditions from 34,465 adult respondents who completed wave 1 (2000-2001) and wave 2 (2004-2005) data collection. Models were adjusted for multiple potentially confounding factors. Read More

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https://academic.oup.com/painmedicine/article-lookup/doi/10.
Publisher Site
http://dx.doi.org/10.1093/pm/pnw252DOI Listing
July 2017
4 Reads

The spectrum of unhealthy drug use and quality of care for hypertension and diabetes: a longitudinal cohort study.

BMJ Open 2015 Dec 21;5(12):e008508. Epub 2015 Dec 21.

Clinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts, USA.

Objectives: Although it is well known that addiction is associated with adverse medical consequences, the effects of the spectrum of unhealthy drug use (illicit drug or prescription misuse) on chronic conditions such as hypertension and diabetes are understudied. This study evaluated the associations between measures of drug use (ie, frequency, severity and type) and standard quality metrics for inadequate blood pressure (BP) and blood glucose (BG) control.

Design: Longitudinal cohort study. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2015-00850
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2015-008508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691731PMC
December 2015
5 Reads

Hysterectomy risk in premenopausal-aged military veterans: associations with sexual assault and gynecologic symptoms.

Am J Obstet Gynecol 2016 Mar 22;214(3):352.e1-352.e13. Epub 2015 Oct 22.

Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA; Center for Comprehensive Access and Delivery Research and Evaluation, Iowa City Veterans Affairs Health Care System, Iowa City, IA.

Background: Several gynecological conditions associated with hysterectomy, including abnormal bleeding and pelvic pain, have been observed at increased rates in women who have experienced sexual assault. Previous findings have suggested that one of the unique health care needs for female military veterans may be an increased prevalence of hysterectomy and that this increase may partially be due to their higher risk of sexual assault history and posttraumatic stress disorder (PTSD). Although associations between trauma, PTSD, and gynecological symptoms have been identified, little work has been done to date to directly examine the relationship between sexual assault, PTSD, and hysterectomy within the rapidly growing female veteran population. Read More

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http://dx.doi.org/10.1016/j.ajog.2015.10.003DOI Listing
March 2016
11 Reads

Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis.

World Psychiatry 2015 Oct;14(3):339-47

Zucker Hillside Hospital, Glen Oaks, NY, USA.

Metabolic syndrome (MetS) and its components are highly predictive of cardiovascular diseases. The primary aim of this systematic review and meta-analysis was to assess the prevalence of MetS and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder, comparing subjects with different disorders and taking into account demographic variables and psychotropic medication use. The secondary aim was to compare the MetS prevalence in persons with any of the selected disorders versus matched general population controls. Read More

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http://dx.doi.org/10.1002/wps.20252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592657PMC
October 2015
16 Reads

Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury.

Neuropsychopharmacology 2016 Apr 11;41(5):1191-8. Epub 2015 Sep 11.

Department of Psychiatry and Department of Family Medicine and Public Health, University of California, San Diego, CA, USA.

We report findings from a 12-week randomized double-blinded placebo-controlled trial of methylphenidate or galantamine to treat emotional and cognitive complaints in individuals (n=32) with a history of PTSD, TBI, or both conditions. In this small pilot study, methylphenidate treatment was associated with clinically meaningful and statistically significant improvement compared with placebo on the primary outcome, a measure of cognitive complaints (Ruff Neurobehavioral Inventory-Postmorbid Cognitive Scale), as well as on the secondary outcomes reflecting post-concussive (Rivermead Post Concussive Symptom Questionnaire) and post-traumatic stress symptoms (Posttraumatic Stress Disorder Checklist). Treatment was well tolerated. Read More

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http://dx.doi.org/10.1038/npp.2015.282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793116PMC
April 2016
20 Reads

Alcohol Dependence, Co-occurring Conditions and Attributable Burden.

Alcohol Alcohol 2016 Mar 4;51(2):201-9. Epub 2015 Aug 4.

Centre for Addiction and Mental Health, Toronto, Canada.

Aims: Alcohol dependence is associated with high rates of co-occurring disorders which impact health-related quality of life (HRQoL) and add to the cost-of-illness. This study investigated the burden of alcohol dependence and associated co-occurring conditions on health and productivity.

Methods: A cross-sectional survey was conducted in eight European countries. Read More

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http://alcalc.oxfordjournals.org/content/alcalc/early/2015/0
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http://www.alcalc.oxfordjournals.org/lookup/doi/10.1093/alca
Publisher Site
http://dx.doi.org/10.1093/alcalc/agv088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755551PMC
March 2016
2 Reads

Deep Brain Stimulation for Obsessive-Compulsive Disorder: A Meta-Analysis of Treatment Outcome and Predictors of Response.

PLoS One 2015 24;10(7):e0133591. Epub 2015 Jul 24.

OCD Clinical and Research Unit, Department of Psychiatry, Hospital de Bellvitge, Barcelona, Spain; Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain; CIBERSAM (Centro de Investigación en Red de Salud Mental), Carlos III Health Institute, Barcelona, Spain; Department of Clinical Sciences, Bellvitge Campus, University of Barcelona, Barcelona, Spain.

Background: Deep brain stimulation (DBS) has been proposed as an alternative to ablative neurosurgery for severe treatment-resistant Obsessive-Compulsive Disorder (OCD), although with partially discrepant results probably related to differences in anatomical targetting and stimulation conditions. We sought to determine the efficacy and tolerability of DBS in OCD and the existence of clinical predictors of response using meta-analysis.

Methods: We searched the literature on DBS for OCD from 1999 through January 2014 using PubMed/MEDLINE and PsycINFO. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133591PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514753PMC
May 2016
16 Reads

A new quantitative method for evaluating freezing of gait and dual-attention task deficits in Parkinson's disease.

J Neural Transm (Vienna) 2015 Nov 24;122(11):1523-31. Epub 2015 Jul 24.

Department of Clinical Neurosciences, Faculty of Medicine, Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.

People with Parkinson's disease (PD) can exhibit disabling gait symptoms such as freezing of gait especially when distracted by a secondary task. Quantitative measurement method of this type of cognitive-motor abnormality, however, remains poorly developed. Here we examined whether stepping-in-place (SIP) with a concurrent mental task (e. Read More

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http://dx.doi.org/10.1007/s00702-015-1423-3DOI Listing
November 2015
54 Reads

Examining Trends and Coexisting Conditions Among Children Qualifying for SSI Under ADHD, ASD, and ID.

Acad Pediatr 2015 Jul-Aug;15(4):439-43

Department of Pediatrics, MassGeneral Hospital for Children, Harvard Medical School, Boston, Mass.

Objective: To examine the prevalence trends and coexisting conditions in attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and intellectual disability (ID) in the pediatric Supplemental Security Income (SSI) population and general population.

Methods: The Social Security Administration (SSA) provided data on primary and secondary diagnoses of children qualifying for SSI for years 2000 to 2011. We compared SSA data with 2000-2011 National Health Interview Survey data on the prevalence of mental health diagnoses among children in the general population living between 0 and 199% of the federal poverty line. Read More

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http://dx.doi.org/10.1016/j.acap.2015.05.002DOI Listing
December 2016
22 Reads

Antidepressants for the treatment of depression in people with cancer.

Cochrane Database Syst Rev 2015 Jun 1(6):CD011006. Epub 2015 Jun 1.

Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Policlinico "GB Rossi", Piazzale L.A. Scuro, 10, Verona, Italy, 37134.

Background: Major depression and other depressive conditions are common in people with cancer. These conditions are not easily detectable in clinical practice, due to the overlap between medical and psychiatric symptoms, as described by diagnostic manuals such as the Diagnostic and Statistical Manual of Mental Disorders (DSM) and International Classification of Diseases (ICD). Moreover, it is particularly challenging to distinguish between pathological and normal reactions to such a severe illness. Read More

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http://dx.doi.org/10.1002/14651858.CD011006.pub2DOI Listing
June 2015
36 Reads