258 results match your criteria Mental Disorders Secondary to General Medical Conditions


Health-related quality of life after 50 years in individuals with thalidomide embryopathy: Evidence from a German cross-sectional survey.

Birth Defects Res 2022 Jun 4. Epub 2022 Jun 4.

Institute of Medical Statistics and Computational Biology, University of Cologne, Cologne, Germany.

Background: As individuals with thalidomide embryopathy now reaching their 60's they undergo long-term sequelae of their prenatal damage and experience a wide range of secondary health problems, in particular chronic musculoskeletal pain, movement restrictions, and mental disorders. These health problems are having a negative impact on their life circumstances and their health-related quality of life (HRQOL).

Objective: The aim of this study was to determine the HRQOL in individuals with thalidomide embryopathy in comparison to individuals of the age-adjusted general population in Germany with and without chronic disease conditions (primary outcome). Read More

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The EMPOWER blended digital intervention for relapse prevention in schizophrenia: a feasibility cluster randomised controlled trial in Scotland and Australia.

Lancet Psychiatry 2022 06;9(6):477-486

Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Australian Catholic University, Melbourne, VIC, Australia.

Background: Early warning signs monitoring by service users with schizophrenia has shown promise in preventing relapse but the quality of evidence is low. We aimed to establish the feasibility of undertaking a definitive randomised controlled trial to determine the effectiveness of a blended digital intervention for relapse prevention in schizophrenia.

Methods: This multicentre, feasibility, cluster randomised controlled trial aimed to compare Early signs Monitoring to Prevent relapse in psychosis and prOmote Well-being, Engagement, and Recovery (EMPOWER) with treatment as usual in community mental health services (CMHS) in Glasgow and Melbourne. Read More

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Association of co-prescribing of opioid and benzodiazepine substitutes with incident falls and fractures among older adults: a cohort study.

BMJ Open 2021 12 30;11(12):e052057. Epub 2021 Dec 30.

Sealy Center on Aging, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.

Objective: Examine the association between the co-prescribing of opioids, benzodiazepines, gabapentinoids (pregabalin and gabapentin) and selective serotonin reuptake inhibitors/serotonin and norepinephrine reuptake inhibitors (SSRI/SNRIs) in different combinations and the risk of falls and fractures.

Design: Retrospective cohort study from 2015 to 2018.

Setting: Medicare enrolment and claims data. Read More

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December 2021

Association of COVID-19 and Endemic Systemic Racism With Postpartum Anxiety and Depression Among Black Birthing Individuals.

JAMA Psychiatry 2022 Jun;79(6):600-609

Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

Importance: The intersection of endemic structural racism and the global health crisis secondary to the COVID-19 pandemic represents a syndemic, defined as the aggregation of 2 or more endemic and epidemic conditions leading to adverse repercussions for health. Long-standing inequities have placed Black individuals at disproportionate risk for negative postpartum mental health outcomes. Studies are urgently needed to understand how the COVID-19 pandemic has added to this risk (eg, syndemic associations). Read More

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Mental Health Symptoms among General Practitioners Facing the Acute Phase of the COVID-19 Pandemic: Detecting Different Reaction Groups.

Int J Environ Res Public Health 2022 03 28;19(7). Epub 2022 Mar 28.

Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.

During the 2020 first wave of the COVID-19 pandemic, general practitioners (GPs) represented the first line of primary care and were highly exposed to the pandemic risks, with a consequent risk of developing a wide range of mental health symptoms. However, scant data are still available on factors associated with a worse outcome. The aim of the present study was to investigate mental health symptoms in 139 GPs in the aftermath of the first COVID-19 national lockdown in Italy, detecting groups of subjects with different depressive, anxiety, and post-traumatic stress symptom severity. Read More

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Fostering socio-emotional competencies in children on the autism spectrum using a parent-assisted serious game: A multicenter randomized controlled trial.

Behav Res Ther 2022 05 5;152:104068. Epub 2022 Mar 5.

Clinical Psychology of Social Interaction, Berlin School of Mind and Brain, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany. Electronic address:

Objective: Serious games are a promising means of fostering socio-emotional skills in children on the autism spectrum (AS). However, empathy and related constructs have not yet been addressed comprehensively and together with emotion recognition, and there is a lack of randomized controlled trials (RCT) to investigate skill maintenance and the transfer to functional behavior.

Method: The manualized, parent-assisted serious game Zirkus Empathico (ZE) was tested against an active control group, in a six-week multicenter RCT. Read More

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Slowing dementia symptoms - a qualitative study on attitudes and experiences of general practitioners in Germany.

Eur J Gen Pract 2022 Dec;28(1):32-39

Centre for General and Geriatric Medicine, University Medical Centre Mainz, Mainz, Germany.

Background: There is currently no cure for dementia but general practitioners (GPs) have therapeutic options available to counteract the progression of mild cognitive impairment, including drug and non-drug treatment. So far, few studies have investigated treatment strategies preferred by GPs.

Objectives: This study aimed to gain an overview of GPs' attitudes towards influencing the progression of dementia, their involvement regarding dementia prevention and perceived effective approaches. Read More

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December 2022

Why mental health service delivery needs to align alongside mainstream medical services.

Asian J Psychiatr 2022 May 25;71:103053. Epub 2022 Feb 25.

Department of Psychiatry, Hamad Medical Corporation, Qatar; College of Medicine, Qatar University, Doha, Qatar.

There is significant individual human suffering and economic burden because of untreated mental health and substance use disorders. There is high psychiatric morbidity in primary and secondary medical care. At least one-fifth of patients attending primary care services in western countries pertain to mental health and one-third of patients attending general hospitals have a comorbid mental disorder. Read More

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Barriers to healthcare and self-reported adverse outcomes for autistic adults: a cross-sectional study.

BMJ Open 2022 Feb 22;12(2):e056904. Epub 2022 Feb 22.

Department of Medical Education, Brighton and Sussex Medical School, Brighton, Brighton and Hove, UK.

Objectives: Autistic people experience poor physical and mental health along with reduced life expectancy compared with non-autistic people. Our aim was to identify self-reported barriers to primary care access by autistic adults compared with non-autistic adults and to link these barriers to self-reported adverse health consequences.

Design: Following consultation with the autistic community at an autistic conference, , we developed a self-report survey, which we administered online through social media platforms. Read More

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February 2022

Association between sleep bruxism, use of antidepressants, and obstructive sleep apnea syndrome: A cross-sectional study.

J Oral Rehabil 2022 May 18;49(5):505-513. Epub 2022 Feb 18.

Dentistry Department, Pontifical Catholic University of Minas Gerais, Belo Horizonte, Brazil.

Background: Sleep bruxism (SB) is a condition regulated centrally, with a multifactorial etiology, which can occur secondary to systemic disorders and the use of certain medications.

Objective: The aim of this study was to identify associations between SB, obstructive sleep apnea, and hypopnea syndrome (OSAHS) and the use of antidepressants.

Material And Methods: In this cross-sectional study, 240 individuals underwent full-night polysomnography for medical reasons. Read More

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The risk of mental illness in people living with HIV in the UK: a propensity score-matched cohort study.

Lancet HIV 2022 03 3;9(3):e172-e181. Epub 2022 Feb 3.

Institute for Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Background: Prevalence of mental illness is higher in people living with HIV than in the general population, but the incidence of composite mental illness and its components is unclear. We aimed to identify the risk of incident mental illness along with individual conditions of depression, anxiety, and severe mental illness in people living with HIV in the UK.

Methods: Data for this population-based cohort were extracted from the IQVIA Medical Research Database, a nationally representative UK-based database of primary care electronic health records. Read More

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Effectiveness and cost-effectiveness of a structured social coaching intervention for people with psychosis (SCENE): protocol for a randomised controlled trial.

BMJ Open 2021 12 13;11(12):e050627. Epub 2021 Dec 13.

Unit for Social and Community Psychiatry, Queen Mary University of London, London, UK.

Introduction: People with psychosis tend to have smaller social networks than both people in the general population and other people with long-term health conditions. Small social networks are associated with poor quality of life. Preliminary evidence suggests that coaching patients to increase their social contacts may be effective. Read More

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December 2021

Impact of insufficient sleep on dysregulated blood glucose control under standardised meal conditions.

Diabetologia 2022 02 30;65(2):356-365. Epub 2021 Nov 30.

Genetic & Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden.

Aims/hypothesis: Sleep, diet and exercise are fundamental to metabolic homeostasis. In this secondary analysis of a repeated measures, nutritional intervention study, we tested whether an individual's sleep quality, duration and timing impact glycaemic response to a breakfast meal the following morning.

Methods: Healthy adults' data (N = 953 [41% twins]) were analysed from the PREDICT dietary intervention trial. Read More

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February 2022

Can a brief training intervention help improve mental health service delivery in South Africa?

Afr J Prim Health Care Fam Med 2021 Oct 26;13(1):e1-e6. Epub 2021 Oct 26.

Department of Education Innovation, Faculty of Academic Cluster, Foundation for Professional Development, Pretoria.

Background: South Africa faces a number of significant challenges apropos mental health service delivery, including a large treatment gap, a high rate of readmission, over-burdened specialist tertiary facilities, and slow integration of mental health into general health services. The South African National Mental Health Education Programme implemented between February 2019 and December 2019, aimed to upskill health workers to diagnose and manage mental disorders at primary and secondary levels of care.

Aim: This study aimed to assess the evolution of training participants' self-reported competency in mental health care and the number of referrals made to higher levels of care as well as to reflect on the possible broader effects of the training. Read More

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October 2021

Major Surgery and Long Term Cognitive Outcomes: The Effect of Postoperative Delirium on Dementia in the Year Following Discharge.

J Surg Res 2022 02 29;270:327-334. Epub 2021 Oct 29.

Division of Acute Care and Regional General Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Background: Delirium is among the most common complications following major surgery. Delirium following medical illness is associated with the development of chronic cognitive decline. The objective of this study was to determine the association of postoperative delirium with dementia in the year following surgery. Read More

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February 2022

A Primary Care-Based Cognitive Behavioral Therapy Intervention for Long-Term Opioid Users With Chronic Pain : A Randomized Pragmatic Trial.

Ann Intern Med 2022 01 2;175(1):46-55. Epub 2021 Nov 2.

Kaiser Permanente Center for Health Research, Portland, Oregon (M.M., A.B., C.R.E., M.C.L., C.M., D.H.S., W.M.V.).

Background: Chronic pain is common, disabling, and costly. Few clinical trials have examined cognitive behavioral therapy (CBT) interventions embedded in primary care settings to improve chronic pain among those receiving long-term opioid therapy.

Objective: To determine the effectiveness of a group-based CBT intervention for chronic pain. Read More

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January 2022

Enteral administration of alectinib for ALK-positive non-small cell lung cancer in an elderly patient: A case report.

Medicine (Baltimore) 2021 Oct;100(43):e27611

Medical Oncology Department, Institut Curie, Paris, France.

Rationale: Alectinib is a tyrosine kinase inhibitor (TKI) approved for use as first-line metastatic therapy for patients with anaplastic lymphoma kinase-rearranged non-small cell lung cancer. Certain medical conditions related to the tumor lesions may not allow oral administration of TKIs.

Patient Concerns: We hereby report the case of a 90-year-old patient with anaplasic lymphoma kinase-rearranged lung cancer with severely impaired general condition and swallowing disorders. Read More

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October 2021

Profile of subjective-objective sleep discrepancy in patients with insomnia and sleep apnea.

J Clin Sleep Med 2021 11;17(11):2155-2163

Osher Center for Integrative Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Study Objectives: Although subjective-objective sleep discrepancy has long been observed in patients with insomnia, the profiles of this discrepancy are poorly understood. Further, sleep discrepancy in insomnia with sleep comorbidities remains underexplored. We sought to better characterize sleep discrepancy among patient groups with and without insomnia and comorbid conditions such as obstructive sleep apnea (OSA). Read More

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November 2021

Challenges and visions for managing pain-related insomnia in primary care using the hybrid CBT approach: a small-scale qualitative interview study with GPs, nurses, and practice managers.

BMC Fam Pract 2021 10 20;22(1):210. Epub 2021 Oct 20.

Department of Psychology, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.

Background: Chronic pain and insomnia have a complex, bidirectional relationship - addressing sleep complaints alongside pain may be key to alleviating patient-reported distress and disability. Healthcare professionals have consistently reported wanting to offer psychologically informed chronic pain management at the primary care level. Research in secondary care has demonstrated good treatment efficacy of hybrid CBT for chronic pain and insomnia. Read More

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October 2021

Advancing the Science of Recovery: The Utility of the Recovery Assessment Scale in the Prediction of Self-Directed Health and Wellness Outcomes in Adults with a Diagnosis of a Serious Mental Illness.

Psychiatr Q 2022 06 13;93(2):443-452. Epub 2021 Oct 13.

College of Social Work, The University of Kentucky, Lexington, KY, USA.

Adults with serious mental illness commonly experience comorbid chronic physical conditions and experience a reduced life expectancy of 10-25 years compared to the general population (Saha et al. in Arch Gen Psychiatry 64(10):1123-31.  2007; Hayes et al. Read More

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Are we making Inroads? A randomized controlled trial of a psychologist-supported, web-based, cognitive behavioral therapy intervention to reduce anxiety and hazardous alcohol use among emerging adults.

EClinicalMedicine 2021 Sep 8;39:101048. Epub 2021 Aug 8.

Sydney School of Health Sciences, University of Sydney, Sydney 2006, Australia.

Background: Anxiety and alcohol use disorders are common and disabling conditions that people typically endure for many years before accessing treatment. The link between anxiety and alcohol use is well-established, with these issues commonly emerging and/or escalating during emerging adulthood. This randomized controlled trial evaluated a psychologist-supported, web-based intervention, designed with and for emerging adults, that aims to promote adaptive coping strategies, and prevent anxiety and alcohol use from progressing to chronic, mutually-reinforcing disorders. Read More

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September 2021

Posterior Reversible Encephalopathy Syndrome Associated With Coarctation of the Aorta.

Cureus 2021 Aug 26;13(8):e17456. Epub 2021 Aug 26.

Pediatric Neurology, Universidade de Mogi das Cruzes, Mogi das Cruzes, BRA.

Posterior reversible encephalopathy syndrome (PRES) is a neurological syndrome characterized by acute encephalopathy due to different medical conditions. This syndrome may present with a wide spectrum of neurological symptoms including headache, disorders of consciousness, visual changes, seizures, and focal neurological deficits, in addition to nonspecific symptoms such as nausea and vomiting. Neuroimaging findings of bilateral cortical and subcortical brain edema involving the parieto-occipital regions are a hallmark of the disease. Read More

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Association of Socioeconomic Status With Dementia Diagnosis Among Older Adults in Denmark.

JAMA Netw Open 2021 05 3;4(5):e2110432. Epub 2021 May 3.

Research Unit of General Practice, Department of Public Health, University of Southern Denmark, Odense, Denmark.

Importance: Low socioeconomic status (SES) has been identified as a risk factor for the development of dementia. However, few studies have focused on the association between SES and dementia diagnostic evaluation on a population level.

Objective: To investigate whether household income (HHI) is associated with dementia diagnosis and cognitive severity at the time of diagnosis. Read More

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A regionally specific drinking custom 'Otōri' and its association with alcohol consumption/alcohol use disorders: a cross-sectional study.

BMJ Open 2021 05 13;11(5):e041738. Epub 2021 May 13.

Division of Clinical Epidemiology, Research Center for Medical Sciences, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.

Objectives: The primary objective was to describe the characteristics of Otōri, a regionally specific drinking custom in the Miyakojima region of Okinawa, Japan, and its participants. The secondary objective was to clarify the distribution of alcohol consumption/alcohol use disorders as measured by the Alcohol Use Disorders Identification Test (AUDIT) and its association with the frequency of engagement in Otōri per month.

Design: Cross-sectional study. Read More

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Mental health responses to the COVID-19 pandemic: a latent class trajectory analysis using longitudinal UK data.

Lancet Psychiatry 2021 07 6;8(7):610-619. Epub 2021 May 6.

Centre for Women's Mental Health, University of Manchester, Manchester, UK; Division of Psychology and Mental Health, University of Manchester, Manchester, UK; Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK.

Background: The mental health of the UK population declined at the onset of the COVID-19 pandemic. Convenience sample surveys indicate that recovery began soon after. Using a probability sample, we tracked mental health during the pandemic to characterise mental health trajectories and identify predictors of deterioration. Read More

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Association of Air Pollution Exposure in Childhood and Adolescence With Psychopathology at the Transition to Adulthood.

JAMA Netw Open 2021 04 1;4(4):e217508. Epub 2021 Apr 1.

King's College London, Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, London, United Kingdom.

Importance: Air pollution exposure damages the brain, but its associations with the development of psychopathology are not fully characterized.

Objective: To assess whether air pollution exposure in childhood and adolescence is associated with greater psychopathology at 18 years of age.

Design, Setting, And Participants: The Environmental-Risk Longitudinal Twin Study is a population-based cohort study of 2232 children born from January 1, 1994, to December 4, 1995, across England and Wales and followed up to 18 years of age. Read More

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Psychopathological symptoms in Spanish subjects with gender dysphoria. A cross-sectional study.

Gynecol Endocrinol 2021 Jun 27;37(6):534-540. Epub 2021 Apr 27.

Department of Clinical Psychology and Psychobiology, Section of Clinical Health Psychology, Clinical Institute of Neurosciences, Hospital Clinic., University of Barcelona, Barcelona, Spain.

Background: Most people with gender dysphoria have to face various stressful conditions, which make them more vulnerable to the development of psychopathological symptoms.

Aims: The main goal was to compare psychopathological symptoms between individuals with gender dysphoria and those from the general population. Other secondary aims were to determine if there were differences between gender [male to females (MtFs) and female to males (FtMs)] and also according to cross-sex hormone therapy. Read More

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Association of Sinonasal Inflammation With Functional Brain Connectivity.

JAMA Otolaryngol Head Neck Surg 2021 06;147(6):534-543

Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts.

Importance: In recent years, there have been several meaningful advances in the understanding of the cognitive effects of chronic rhinosinusitis. However, an investigation exploring the potential link between the underlying inflammatory disease and higher-order neural processing has not yet been performed.

Objective: To describe the association of sinonasal inflammation with functional brain connectivity (Fc), which may underlie chronic rhinosinusitis-related cognitive changes. Read More

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Prevalence of depression and anxiety in people with inflammatory bowel disease and associated healthcare use: population-based cohort study.

Evid Based Ment Health 2021 Mar 30. Epub 2021 Mar 30.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Background: Inflammatory bowel disease (IBD) has a significant impact on quality of life for many people.

Objective: To assess the prevalence of common mental health conditions in IBD and the combined impact of IBD and mental health conditions on healthcare use and time off work.

Methods: A UK population-based primary care database (Royal College of General Practitioners Research and Surveillance Centre) was used to identify adults with IBD (n=19 011) (Crohn's disease (CD) or ulcerative colitis (UC)), and matched controls (n=76 044). Read More

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