6,256 results match your criteria Menorrhagia

An Immunologic Storm: A Case of Encephalitis and Thrombotic Thrombocytopenic Purpura With Underlying Likely Sjogren's Syndrome Induced by a COVID-19 Immune Response.

Neurohospitalist 2022 Jul 11;12(3):529-535. Epub 2022 Mar 11.

Department of Pediatric Neurology, University of Tennessee Health Sciences Center, Memphis TN, USA.

Introduction: There are rare cases of Sjogren's syndrome presenting with manifestations of encephalitis. There are also rare patients with Sjogren's presenting with acute thrombotic thrombocytopenic purpura (TTP). There are no cases of both occurring together as the only symptoms of the syndrome. Read More

View Article and Full-Text PDF

Menstrual hygiene practices and associated factors among Indian adolescent girls: a meta-analysis.

Reprod Health 2022 Jun 23;19(1):148. Epub 2022 Jun 23.

Division of Public Health Science, Institute for Health Sciences, Mid Sweden University, Sundsvall, Sweden.

Background: Menstrual hygiene management (MHM) and practices by adolescent females of low and middle-income countries (LMICs) are a severe public health issue. The current systematic review and meta-analysis aimed to estimate the pooled proportion of the hygiene practices, menstrual problems with their associated factors, and the effectiveness of educational interventions on menstrual hygiene among adolescent school girls in India.

Methods: PRISMA checklist and PICO guidelines were used to screen the scientific literature from 2011 to 2021. Read More

View Article and Full-Text PDF

Psychosocial Problems of Adolescent Girls during Menstruation.

J Mental Health Educ 2022 Apr;3(2):47-63

Associate Professor, Department of Psychiatric Social Work, NIMHANS, Bangalore, Karnataka.

Aim: To study the psychosocial problems of adolescent girls during menstruation.

Methods: Cross-sectional study was conducted in Chennai. Descriptive research design was used. Read More

View Article and Full-Text PDF

Quality of Life of Japanese Dysmenorrhea/Heavy Menstrual Bleeding Patients Treated with Levonorgestrel Intrauterine Delivery System in a Real-World Setting.

Adv Ther 2022 Jun 16. Epub 2022 Jun 16.

Market Access, Bayer Yakuhin, Ltd., 1-6-5 Marunouchi, Chiyoda-ku, Tokyo, 100-8265, Japan.

Introduction: The present study collected 1-year follow-up patient-reported outcome data from Japanese women with dysmenorrhea and/or heavy menstrual bleeding (HMB) who underwent insertion of the levonorgestrel-releasing intrauterine system (LNG-IUS) 52 mg. We aimed to evaluate the quality of life (QOL) of Japanese women over the course of the investigational period.

Methods: This was a multicenter, non-interventional, prospective, single-cohort, post-marketing surveillance study (J-MIRAI). Read More

View Article and Full-Text PDF

Epigenomic Analysis Reveals the KCNK9 Potassium Channel as a Potential Therapeutic Target for Adenomyosis.

Int J Mol Sci 2022 May 26;23(11). Epub 2022 May 26.

Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.

Adenomyosis is linked to dysmenorrhea and infertility. The pathogenesis of adenomyosis remains unclear, and little is known of the genetic and epigenetic changes in the eutopic endometrium in adenomyosis, which may predispose patients to the invasion and migration of endometrial tissues into the myometrium. Transcriptome studies have identified genes related to various cell behaviors but no targets for therapeutic intervention. Read More

View Article and Full-Text PDF

Relugolix Combination Therapy for Uterine Leiomyoma-Associated Pain in the LIBERTY Randomized Trials.

Obstet Gynecol 2022 Jun 2;139(6):1070-1081. Epub 2022 May 2.

Mayo Clinic, Rochester, Minnesota; the Carolina Woman's Research and Wellness Center, Durham, North Carolina; the Department of Clinical and Experimental Medicine, Unit of Obstetrics and Gynecology, Magna Graecia University of Catanzaro, Catanzaro, Italy; Myovant Sciences, Inc., Brisbane, California; Myovant Sciences GmbH, Basel, Switzerland; and the Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois.

Objective: To assess the effect of once-daily relugolix combination therapy (relugolix-CT: relugolix 40 mg, estradiol 1 mg, and norethindrone acetate 0.5 mg) compared with placebo on moderate-to-severe pain in women with uterine leiomyomas and heavy menstrual bleeding.

Methods: Two replicate, multinational, double-blind, 24-week, randomized, phase 3 studies (LIBERTY 1 and 2) were conducted in premenopausal women with uterine leiomyoma-associated heavy menstrual bleeding (80 mL or greater per cycle for two cycles or 160 mL or greater during one cycle). Read More

View Article and Full-Text PDF

The Relationship Between Menstrual Patterns and Menstrual Attitude Dimensions among Women of Reproductive Age: Cross-sectional survey.

Sultan Qaboos Univ Med J 2022 May 26;22(2):241-246. Epub 2022 May 26.

Department of Midwifery, Neyshabur University of Medical Sciences, Neyshabur, Iran.

Objectives: Women's attitudes towards menstruation play a critical role in shaping their bodies and psychosocial integrity. Menstruation is affected by certain bio-psychosocial factors, necessitating an in-depth understanding of the phenomenon to cope better with the consequent difficulties. This study aimed to investigate the relationship between menstrual patterns and menstrual attitude dimensions in women of reproductive-age. Read More

View Article and Full-Text PDF

Menstrual problems in chronic immune thrombocytopenia: A monthly challenge - a cohort study and review.

Br J Haematol 2022 Jun 3. Epub 2022 Jun 3.

Center for Benign Hematology, Thrombosis and Hemostasis, Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Immune thrombocytopenia (ITP) may cause menstrual problems. This cross-sectional study assessed menstrual problems in premenopausal chronic ITP women by several questionnaires, including the pictorial bleeding assessment calendar (PBAC; score ≥100 indicates heavy menstrual bleeding [HMB]), and the menorrhagia multiattribute scale (MMAS). Spearman was used for assessing correlations. Read More

View Article and Full-Text PDF

Efficiency of intravenous iron carboxymaltose in patients with iron-deficiency anemia due to heavy menstrual bleeding: a single-center experience.

Eur Rev Med Pharmacol Sci 2022 May;26(10):3487-3492

Department of Hematology and Bone Marrow Transplantation Center, University of Health Sciences, Ankara Oncology Training and Research Hospital, Ankara, Turkey.

Objective: Heavy menstrual bleeding (HMB) is the most common cause of iron deficiency anemia (IDA) in premenopausal women. Clinical studies have shown that iron carboxymaltose (ICM) is an appropriate, effective, and well-tolerated treatment option for clinical situations associated with iron deficiency (ID).

Patients And Methods: This study took 78 out of 400 consecutive patients diagnosed with IDA due to HMB and intolerant or insufficient response of oral iron. Read More

View Article and Full-Text PDF

Uterine Involvement in Klippel-Trenaunay Syndrome: A Rare But Relevant Event. Review of the Literature.

Front Surg 2022 12;9:893320. Epub 2022 May 12.

Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy.

Introduction: Klippel-Trenaunay syndrome (KTS) is a rare vascular congenital disorder characterized by the classical triad of port-wine stains, abnormal growth of soft tissues and bones, and vascular malformations. The involvement of the genitourinary tract and of the uterus in particular is extremely infrequent but relevant for possible consequences.

Methods: We performed an extensive review of the literature using the Pubmed, Scopus and ISI web of knowledge database to identify all cases of KTS with uterine involvement. Read More

View Article and Full-Text PDF

Special Considerations for Women of Reproductive Age on Anticoagulation.

J Gen Intern Med 2022 May 31. Epub 2022 May 31.

Department of Internal Medicine, Division of General Internal Medicine, University of California San Francisco, San Francisco, CA, USA.

Anticoagulation poses unique challenges for women of reproductive age. Clinicians prescribing anticoagulants must counsel patients on issues ranging from menstruation and the possibility of developing a hemorrhagic ovarian cyst to teratogenic risks and safety with breastfeeding. Abnormal uterine bleeding affects up to 70% of young women who are treated with anticoagulation. Read More

View Article and Full-Text PDF

The effect of transcervical resection of submucous fibroids on menstrual blood loss: A prospective cohort study.

Eur J Obstet Gynecol Reprod Biol 2022 Jul 21;274:128-135. Epub 2022 May 21.

Amsterdam UMC, Location VUmc, Department of Obstetrics and Gynecology, De Boelelaan 1117 1081 HV Amsterdam, The Netherlands.

Objectives: Transcervical resection of myoma (TCRM) is a widely implemented treatment for submucous fibroids. The aim of this study is to evaluate the effect of TCRM on menstrual bleeding, fibroid related symptoms and quality of life and hemoglobin (Hb) levels.

Study Design: A prospective cohort study was conducted in three teaching hospitals and two academic hospitals in the Netherlands. Read More

View Article and Full-Text PDF

Interventions for heavy menstrual bleeding; overview of Cochrane reviews and network meta-analysis.

Cochrane Database Syst Rev 2022 05 31;5:CD013180. Epub 2022 May 31.

Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

Background: Heavy menstrual bleeding (HMB) is excessive menstrual blood loss that interferes with women's quality of life, regardless of the absolute amount of bleeding. It is a very common condition in women of reproductive age, affecting 2 to 5 of every 10 women. Diverse treatments, either medical (hormonal or non-hormonal) or surgical, are currently available for HMB, with different effectiveness, acceptability, costs and side effects. Read More

View Article and Full-Text PDF

Evaluation and management of abnormal uterine bleeding.

K S Achanna J Nanda

Med J Malaysia 2022 05;77(3):374-383

Mahsa University, Jalan SP2, Bandar Saujana Putra, Jenjarom, Kuala Langat, Selangor, Malaysia.

Abnormal uterine bleeding (AUB) is one of the commonest complaints of women in reproductive age and non-gravid state that brings them to the attention of the primary care doctor or the gynaecologist. Anovulation without any medical illness or pelvic pathology seems to be the common cause. Bleeding due to a wide variation in pathology both inside and outside the reproductive tract can be termed as anovulatory bleeding. Read More

View Article and Full-Text PDF

Emerging Treatment Options for Fibroids.

Obstet Gynecol Clin North Am 2022 Jun;49(2):299-314

Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.

Leiomyomas (fibroids) are common, usually benign, monoclonal tumors that arise from the uterine myometrium. Clinical presentation is variable; some patients are asymptomatic, whereas others experience heavy menstrual bleeding, pain, bulk symptoms, and/or alterations in fertility. Previously, treatment options for fibroids were largely surgical. Read More

View Article and Full-Text PDF

Uterine Adenosarcoma in a Teen Ager.

J Coll Physicians Surg Pak 2022 Apr;32(4):S18-S20

Department of Anesthesiology, The First Hospital of Jilin University, Xinmin Street, Changchun, Jilin, China.

Uterine adenosarcoma is a rare tumor composed of benign epithelium in combination with malignant mesenchymal components. Misdiagnosis is common due to the lack of specific clinical manifestations and the rarity of such tumors in young age groups. The mean age at diagnosis is 58. Read More

View Article and Full-Text PDF

Long-term incidence of endometrial cancer after endometrial resection and ablation: A population based Swedish gynecologic cancer group (SweGCG) study.

Acta Obstet Gynecol Scand 2022 May 27. Epub 2022 May 27.

Department of Obstetrics and Gynecology, Skåne University Hospital, Lund University, Lund, Sweden.

Introduction: Minimally invasive methods to reduce menorrhagia were introduced in the 1980s and 1990s. Transcervical endometrial resection (TCRE) and endometrial ablation (EA) are two of the most frequently used methods. As none of them can guarantee a complete removal of the endometrium, there are concerns that the remaining endometrium may develop to endometrial cancer (EC) later in life. Read More

View Article and Full-Text PDF

Bleeding patterns of women with heavy menstrual bleeding or dysmenorrhoea using the levonorgestrel-releasing intrauterine system: results from a real-world observational study in Japan (J-MIRAI).

Eur J Contracept Reprod Health Care 2022 May 25:1-8. Epub 2022 May 25.

PMS Pharmacovigilance Monitoring & Governance, Bayer Yakuhin, Ltd., Osaka, Japan.

Purpose: To collect real-world safety and clinical outcome data on the levonorgestrel-releasing intrauterine system (LNG-IUS) for functional/organic heavy menstrual bleeding (HMB) and dysmenorrhoea in Japanese women (J-MIRAI).

Materials And Methods: In this prospective, multicentre, single-cohort, open-label, post-authorisation study, we assessed menstrual blood loss after LNG-IUS insertion by changes from baseline in pictorial blood loss assessment chart (PBAC) scores. Scores for the menorrhagia multi-attribute scale (MMAS) were collected for 12 months to assess quality of life. Read More

View Article and Full-Text PDF

Levonorgestrel-Releasing Intrauterine Device Use Can Be a Treatment Option in Symptomatic Patients with Isthmocele.

Reprod Sci 2022 May 24. Epub 2022 May 24.

Department of Obstetrics and Gynecology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.

Levonorgestrel-releasing intrauterine devices have been used for contraception and treatment of heavy menstrual bleeding. There is only limited data about the effect of this on isthmocele. Here, we aimed to evaluate the effect of levonorgestrel-releasing intrauterine devices in a larger study population with a longer follow-up as compared to the literature on symptomatic patients with isthmocele. Read More

View Article and Full-Text PDF

Risk factors for primary dysmenorrhea and the effect of complementary and alternative treatment methods: Sample from Corum, Turkey.

Int J Health Sci (Qassim) 2022 May-Jun;16(3):35-43

Department of Obstetrics and Gynecology Nursing, Faculty of Health Sciences, Yakın Doğu University, Lefkoşa/Mersin, Turkey.

Objective: Dysmenorrhea is defined as menstrual pain that develops due to uterine menstrual contractions. When the literature is examined, there are a limited number of studies about the frequency of primary dysmenorrhea (PD), influencing factors, and complementary and alternative treatment methods (CAMs) in Turkey. In this study, the aim was to determine the risk factors for PD and the effect of CAM use on PD in female university students. Read More

View Article and Full-Text PDF

The Development of Immune Thrombocytopenia Due to COVID-19 Presenting as Menorrhagia.

Cureus 2022 Apr 15;14(4):e24160. Epub 2022 Apr 15.

Internal Medicine, Indiana University Health Ball Memorial Hospital, Muncie, USA.

Immune thrombocytopenia (ITP), also known as immune thrombocytopenic purpura, is a hematological disorder characterized by a decreased platelet count, predisposing patients to bleeding. Coronavirus disease 2019 (COVID-19) has been linked to multiple cases of newly diagnosed ITP and is usually found in moderate-to-severe infections, peaking in children and elderly adults. Menorrhagia is the medical term for menstrual periods with abnormally heavy or prolonged bleeding occurring at regular intervals or prolonged uterine bleeding lasting more than seven days. Read More

View Article and Full-Text PDF

Uterus didelphys complicated with endometrial carcinoma: A case report of uterus didelphys with endometrial carcinoma.

Medicine (Baltimore) 2022 May 6;101(18):e29183. Epub 2022 May 6.

Department of Gynecological Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, P.R. China.

Rationale: The incidence of uterine malformations is low (4%-7%). Currently, the National Comprehensive Cancer Network clinical practice guidelines in oncology recommend minimally invasive surgery for early endometrial cancer. Minimally invasive surgery for the treatment of uterine didelphys with endometrial cancer is rare due to the large size of the uterus. Read More

View Article and Full-Text PDF

Abnormal uterine bleeding in adolescents.

Curr Probl Pediatr Adolesc Health Care 2022 05 4;52(5):101185. Epub 2022 May 4.

Division of Adolescent Medicine, Cohen Children's Medical Center, Northwell Health, 410 Lakeville Road, Suite 108, New Hyde Park, New York, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.

Abnormal uterine bleeding (AUB) is a common diagnosis in the adolescent female population. In recent years, changes have been made to standardize nomenclature, evaluation and management of AUB in adolescents. The terms "abnormal uterine bleeding" and "heavy menstrual bleeding" have replaced terms including "dysfunctional uterine bleeding," "menorrhagia," "metrorrhagia", and "menometrorrhagia. Read More

View Article and Full-Text PDF

Health issues in women and girls affected by haemophilia with a focus on nomenclature, heavy menstrual bleeding, and musculoskeletal issues.

Haemophilia 2022 May;28 Suppl 4:18-25

Departments of Medicine, and Laboratory Medicine and Pathobiology, St. Michael's Hospital, Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Ontario, Canada.

Introduction: Women and girls affected by haemophilia, including haemophilia carriers (WGH) are at risk of bleeding symptoms that may go unrecognized, including heavy menstrual bleeding (HMB) and musculoskeletal bleeding. Terminology continues to evolve.

Aim: To describe the current recommendations for nomenclature surrounding WGH, and the current understanding of HMB, iron deficiency, and musculoskeletal complaints in these patients. Read More

View Article and Full-Text PDF

Rhabdomyolysis after Intravenous Ferric Gluconate: A Case Report.

Eur J Case Rep Intern Med 2022 21;9(4):003325. Epub 2022 Apr 21.

Centre for Rare Diseases - Disorders of Iron Metabolism, ASST-Monza, San Gerardo Hospital, Monza, Italy.

Patients with severe iron deficiency, malabsorption or intolerance to oral iron are frequently treated with intravenous iron replacement. We report the case of a 42-year-old woman with non-erosive oligoarticular arthritis with antiparietal cell antibodies and iron deficiency anemia secondary to menorrhagia and unresponsive to oral iron preparations. She was treated with an intravenous infusion of ferric gluconate. Read More

View Article and Full-Text PDF

Glucocorticoid receptor blockers.

Mark E Molitch

Pituitary 2022 May 4. Epub 2022 May 4.

Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.

Mifepristone is the only glucocorticoid receptor antagonist currently approved for the treatment of Cushing's syndrome. Although originally developed as an abortifacient due to its blockade of the progesterone receptor, a number of case reports documented its efficacy as a glucocorticoid receptor blocker going back to 1985. The SEISMIC trial, published in 2012, provided sufficient data on efficacy and adverse effects for regulatory approval. Read More

View Article and Full-Text PDF

Experiences of access and use of contraceptive care during COVID-19 lockdown in the UK: a web-based survey.

BJGP Open 2022 Apr 29. Epub 2022 Apr 29.

Child Health Unit, Department of Primary Care and Public Health, Imperial College London, London, United Kingdom.

Background: The first wave of lockdown measures to control the covid-19 pandemic in the United Kingdom (UK) resulted in suspension of "non-essential" services including contraception.

Aim: To examine women's perceptions and experiences of contraceptive care in the UK during the first lockdown.

Design & Setting: Cross-sectional survey during lockdown period from March to June 2020. Read More

View Article and Full-Text PDF

Intrapartum versus postpartum insertion of intrauterine device in women delivering by cesarean section.

BMC Pregnancy Childbirth 2022 Apr 28;22(1):365. Epub 2022 Apr 28.

Obstetrics and Gynecology Department, Faculty of Medicine, MINIA University, Minya, Egypt.

Background: The intrauterine device (IUD), being a reversible and effective contraception method, is the most widely used worldwide. This study aims to demonstrate the efficacy of IUD insertion during elective lower segment cesarean section (LSCS) versus its insertion six weeks postpartum.

Methods: A cohort study was conducted on 200 women planned for elective cesarean delivery and desired IUD as a contraceptive method. Read More

View Article and Full-Text PDF

Assessment of Iron Status in Adolescents Presenting to the Emergency Department With Heavy Menstrual Bleeding.

Pediatr Emerg Care 2022 May 12;38(5):e1266-e1270. Epub 2022 Jan 12.

Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI.

Objective: Iron deficiency is extremely common in adolescents with heavy menstrual bleeding (HMB) presenting to the emergency department; however, patients are rarely screened for this. The objective of this study was to evaluate screening for iron deficiency in adolescents presenting to the emergency department for HMB.

Methods: This is a secondary analysis of a single-center, cross-sectional observational study using retrospective chart review. Read More

View Article and Full-Text PDF