5,713 results match your criteria Menorrhagia


Metastatic low-grade endometrial stromal sarcoma of uterus presenting as a primary pancreatic tumor: case presentation and literature review.

Diagn Pathol 2019 Apr 22;14(1):30. Epub 2019 Apr 22.

Department of Anatomical Pathology, Laboratory Medicine Program, University Health Network, Toronto General Hospital, 200 Elizabeth Street, 11th Floor, Eaton Wing, Toronto, Ontario, M5G 2C4, Canada.

Background: Metastatic tumors to the pancreas are uncommon, accounting for approximately 2% of pancreatic malignancies. The most common primary tumors to give rise to pancreatic metastases are carcinomas.

Case Presentation: A 50-year old female patient was investigated for a cause of abdominal discomfort. Read More

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http://dx.doi.org/10.1186/s13000-019-0807-3DOI Listing
April 2019
1 Read

[Measurement of uterine volume in patients with endometriosis and its clinical significance].

Zhonghua Fu Chan Ke Za Zhi 2019 Apr;54(4):245-248

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China.

To measure the uterine volume by ultrasonic imaging in nullipara patients with endometriosis and analyze its clinical significance. From July 1st, 2016 to August 1st, 2017, 107 cases of nullipara patients with endometriosis hospitalized in Peking University First Hospital were selected as endometriosis group. Among 107 cases, 59 cases were in proliferative phase of menstrual cycle, 48 cases were in secretory phase; and 10 cases had an abortion history. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.04.006DOI Listing

Combined therapeutic effects of HIFU, GnRH-a and LNG-IUS for the treatment of severe adenomyosis.

Int J Hyperthermia 2019 17;36(1):486-492. Epub 2019 Apr 17.

a Department of Gynecology, Shanghai First Maternity and Infant Hospital , Tongji University School of Medicine , Shanghai , PR China.

Objective: To evaluate the combined efficacy of high-intensity focused ultrasound (HIFU), gonadotropin-releasing hormone agonist (GnRH-a) and the levonorgestrel-releasing intrauterine system (LNG-IUS) for the treatment of severe adenomyosis.

Method: Four hundred and sixty-six patients with adenomyosis admitted to the Department of Gynecology of Shanghai First Maternity and Infant Hospital underwent HIFU treatment, and then were consecutively administered with GnRH-a 1 d, 1 month and 3 months after HIFU treatment. The uterine size was then measured with ultrasound or MRI 2-4 weeks after three cycles of GnRH-a injection. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2019.1
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http://dx.doi.org/10.1080/02656736.2019.1595179DOI Listing
April 2019
4 Reads

Premenstrual syndrome in Anand District, Gujarat: A cross-sectional survey.

J Family Med Prim Care 2019 Feb;8(2):640-647

Department of Paediatrics, Pramukhswami Medical College, Karamsad, Gujarat, India.

Aim Of Study: We assessed the prevalence and severity of premenstrual syndrome (PMS) in adolescents and identified probable associations of PMS and premenstrual dysphoric disorder (PMDD) with age, locality, food habits, obesity, stress, genetic influence, menorrhagia and dysmenorrhoea.

Methods: Cross-sectional study in schools of Anand District in State of Gujarat, India. We conducted the study in 1702 girls in the age group of 8-23 years who had achieved menarche. Read More

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http://www.jfmpc.com/text.asp?2019/8/2/640/252996
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http://dx.doi.org/10.4103/jfmpc.jfmpc_302_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436252PMC
February 2019
4 Reads

Laparoscopic Myomectomy with Temporary Bilateral Uterine Artery and Utero-Ovarian Vessels Occlusion Compared with Traditional Surgery for Uterine Fibroids: Blood Loss and Recurrence.

Gynecol Obstet Invest 2019 Apr 9:1-7. Epub 2019 Apr 9.

Department of Obstetrics and Gynecology, Jinhua Hospital of Zhejiang University, Jinhua, China,

Aim: To determine the optimal hemostatic technique for laparoscopic myomectomy (LM) by comparing temporary uterine artery blockage alone or combined with blockage of the utero-ovarian vessels.

Patients: Women with symptomatic uterine myoma attending the Department of Obstetrics and Gynecology in Jinhua Municipal Central Hospital.

Method: A total of 200 patients with symptomatic uterine fibroids were randomly divided into Group A (n = 65), Group B (n = 67) and Group C (n = 68). Read More

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https://www.karger.com/Article/FullText/499494
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http://dx.doi.org/10.1159/000499494DOI Listing
April 2019
5 Reads

Unusual case of intra-abdominal candidiasis following laparoscopic hysterectomy.

BMJ Case Rep 2019 Apr 4;12(4). Epub 2019 Apr 4.

Obstetrics and Gynaecology, KK Women's and Children's Hospital, Singapore.

A 41-year-old woman with menorrhagia secondary to adenomyosis underwent an elective uncomplicated total laparoscopic hysterectomy after failed medical therapy. She developed fever, epigastric pain, nausea and diarrhoea on postoperative day (POD) 2. CT of abdomen and pelvis performed on POD 3 revealed an 8×3×3 cm fluid collection superior to the bladder. Read More

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http://dx.doi.org/10.1136/bcr-2018-227897DOI Listing
April 2019
1 Read

Comparative efficacy and safety of intravenous ferric carboxymaltose and iron sucrose for the treatment of preoperative anemia in patients with menorrhagia: An open-label, multicenter, randomized study.

J Obstet Gynaecol Res 2019 Apr;45(4):858-864

Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.

Aim: To compare ferric carboxymaltose (FCM) with iron sucrose (IS) for the effective and timely treatment of preoperative iron deficiency anemia (IDA) in women with menorrhagia.

Methods: This open-label, multicenter, two-arm study randomized patients to receive either a single dose of FCM or multiple doses of IS. The primary endpoint was the proportion of patients who achieved hemoglobin (Hb) levels ≥10 g/dL within 2 weeks after the first administration. Read More

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http://dx.doi.org/10.1111/jog.13893DOI Listing
April 2019
3 Reads

Adenomyosis:A Clinico-pathological Study.

West Afr J Med 2019 Jan-Apr;36(1):88-92

Department of Histopathology, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.

Background: Adenomyosis is defined by the presence within the myometrium of benign endometrial glands and stroma. Several theories have evolved to explain the pathogenesis of adenomyosis. A third of adenomyosis cases are asymptomatic. Read More

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March 2019
1 Read

Medical Child Abuse: An Unusual "Source" of Vaginal Bleeding.

J Pediatr Adolesc Gynecol 2019 Mar 25. Epub 2019 Mar 25.

Section of Adolescent Medicine, Department of Pediatrics, University of Oklahoma Health Sciences Center, 1200 Children's Avenue, Suite 12204 Oklahoma City, OK 73014. Electronic address:

Background: Medical child abuse (MCA) is challenging to diagnose. While young children are often affected, adolescents can be victims through caregiver coercion. Presentation is highly variable. Read More

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http://dx.doi.org/10.1016/j.jpag.2019.03.003DOI Listing
March 2019
1 Read

Perspectives of women experiencing Menorrhagia: A descriptive qualitative study.

J Clin Nurs 2019 Mar 27. Epub 2019 Mar 27.

Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.

Objective: To describe the perspectives and support needs of women experiencing menorrhagia in Singapore.

Background: Women with menorrhagia lack awareness regarding the severity of menorrhagia. There is a dearth of literature understanding the support needs of women with menorrhagia. Read More

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http://dx.doi.org/10.1111/jocn.14856DOI Listing
March 2019
5 Reads

Menstrual disorders and quality of life of women in an urban area of Puducherry: A community-based cross-sectional study.

J Family Med Prim Care 2019 Jan;8(1):137-140

Department of Preventive and Social Medicine, JIPMER, Puducherry, India.

Background: Menstrual disorders are common among women in reproductive age group and affect their normal functioning and social life. Due to cultural reasons, menstrual problems often get unreported. In India, the literature on the effect of menstrual disorders on the quality of life (QOL) of women is limited. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_209_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396583PMC
January 2019
1 Read

Congenital Factor X deficiency in women: A systematic review of the literature.

Haemophilia 2019 Mar;25(2):195-204

Katharine Dormandy Haemophilia Centre, Department of Obstetrics & Gynaecology, Royal Free Hospital, London, UK.

Factor X deficiency (FXD) is a rare autosomal recessive bleeding disorder with a variable phenotypic severity. In women, heavy menstrual bleeding (HMB), recurrent ovulation bleeding with haemoperitoneum and bleeding complications in pregnancy such as retroplacental haematoma and postpartum haemorrhage have been reported. The aim of this review was to examine gynaecological problems and obstetric complications in women with congenital FXD. Read More

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http://dx.doi.org/10.1111/hae.13729DOI Listing
March 2019
4 Reads

Placenta Increta Presenting as Retained Placenta: A Report of 3 Cases.

Fetal Pediatr Pathol 2019 Mar 19:1-11. Epub 2019 Mar 19.

b Pathology & Laboratory Medicine , Rutgers-New Jersey Medical School , Newark , NJ , USA.

Objectives: Morbid adherence is a risk factor for retained placenta (RP). We encountered three cases of placenta increta presenting clinically as delayed postpartum hemorrhage.

Methods: This was a retrospective study of three cases of placenta increta presenting as RP. Read More

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http://dx.doi.org/10.1080/15513815.2019.1582121DOI Listing
March 2019
2 Reads

Predictors of a Successful Bipolar Radiofrequency Endometrial Ablation.

Geburtshilfe Frauenheilkd 2019 Mar 12;79(3):286-292. Epub 2019 Mar 12.

Frauenklinik, Kantonsspital Frauenfeld, Frauenfeld, Switzerland.

The study's objectives were to determine the success rate following radiofrequency endometrial ablation to treat abnormal menstrual bleeding and to assess risk factors for failure of the method. 195 women who were treated with bipolar radiofrequency endometrial ablation between 01/2009 and 06/2016 were included in this prospective cohort study. Postoperative data from 187 women were collected at a median of 17. Read More

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http://dx.doi.org/10.1055/a-0733-5798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414303PMC
March 2019
1 Read

Intrauterine cystic adenomyosis: Report of two cases.

World J Clin Cases 2019 Mar;7(5):676-683

Department of Obstetrics and Gynecology, the First Hospital of Jilin University, Changchun 130021, Jilin Province, China.

Background: Cystic adenomyosis is a special type of adenomyosis. Its clinical manifestations lack specificity. Pelvic ultrasound and nuclear magnetic resonance imaging can help clarify the diagnosis. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i5.676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406199PMC

Structural studies of plasmin inhibition.

Biochem Soc Trans 2019 Mar 5. Epub 2019 Mar 5.

ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Melbourne 3800, Australia

Plasminogen (Plg) is the zymogen form of the serine protease plasmin (Plm), and it plays a crucial role in fibrinolysis as well as wound healing, immunity, tissue remodeling and inflammation. Binding to the targets via the lysine-binding sites allows for Plg activation by plasminogen activators (PAs) present on the same target. Cellular uptake of fibrin degradation products leads to apoptosis, which represents one of the pathways for cross-talk between fibrinolysis and tissue remodeling. Read More

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http://dx.doi.org/10.1042/BST20180211DOI Listing
March 2019
6 Reads

Medicinal Uses, Phytochemistry and Pharmacological Properties of .

Nutrients 2019 Mar 4;11(3). Epub 2019 Mar 4.

Technology Transfer Office, Research Administration and Development Department, University of Limpopo, Private Bag X1106, Sovenga 0727, South Africa.

is a plant species, which is in high demand as a herbal medicine in southern Africa. This study critically reviewed the medicinal applications, phytochemistry and pharmacological activities of . The literature on medicinal applications, phytochemical, and pharmacological activities of , was collected from multiple internet sources including Elsevier, Google Scholar, SciFinder, Web of Science, Pubmed, BMC, Science Direct, and Scopus. Read More

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http://dx.doi.org/10.3390/nu11030545DOI Listing
March 2019
7 Reads

Characterizing adolescents with heavy menstrual bleeding and generalized joint hypermobility.

Pediatr Blood Cancer 2019 Jun 25;66(6):e27675. Epub 2019 Feb 25.

Division of Pediatric Hematology/Oncology, Nationwide Children's Hospital/The Ohio State University, Ohio, Columbus.

Patients with generalized joint hypermobility (JHM) may experience excessive bruising/bleeding, with heavy menstrual bleeding (HMB) commonly reported. We performed a retrospective review of 30 adolescents seen in a Young Women's Hematology Clinic with both HMB and JHM. We found that (1) a significant delay (mean 36 months, range 5-72) occurred between menarche and referral to specialty care, (2) HMB had moderate to severe impact on school and physical activities in 60% of patients, and (3) most patients (68%) required escalation of their initial therapy. Read More

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http://doi.wiley.com/10.1002/pbc.27675
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http://dx.doi.org/10.1002/pbc.27675DOI Listing
June 2019
7 Reads

Glanzmann Thrombasthenia in Children: Experience From a Tertiary Care Center in Southern India.

J Pediatr Hematol Oncol 2019 Mar;41(2):e68-e71

Departments of Paediatrics.

Background: Glanzmann thrombasthenia (GT) is a globally rare inherited disorder of hemostasis.

Objectives: To describe the clinical profile of GT in a tertiary care center in Southern India.

Methods: A retrospective chart review of all children with GT was performed between January 2005 and August 2017 in the Department of Paediatrics. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001367DOI Listing
March 2019
2 Reads
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Factors associated with receiving surgical treatment for menorrhagia in England and Wales: findings from a cohort study of the National Heavy Menstrual Bleeding Audit.

BMJ Open 2019 Feb 19;9(2):e024260. Epub 2019 Feb 19.

Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.

Objective: To examine the factors associated with receiving surgery for heavy menstrual bleeding (HMB) in England and Wales.

Design: National cohort study.

Setting: National Health Service hospitals. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377553PMC
February 2019
5 Reads

The prevalence of menstrual disorders in Iran: A systematic review and meta-analysis.

Int J Reprod Biomed (Yazd) 2018 Nov;16(11):665-678

Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Background: Understanding the prevalence of menstrual disorders has important implications for both health service planning and risk factor epidemiology.

Objective: The aim of this review is to identify and collate studies describing the prevalence of menstrual disorders in Iran.

Materials And Methods: Studies with original data related to the prevalence of menstrual disorders were identified via searching six electronic databases and reviewing citations. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350848PMC
November 2018
4 Reads

[On the Issue of Register of Patients of Gynecological Profile with Anemia Syndrome].

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2018 Nov;26(6):436-439

The Federal State Budget Educational Institution of Higher Education «The N. N. Burdenko Voronezh State Medical University» of the Ministry of Health of Russia, 394036, Voronezh, Russia.

The abundant menorrhagia is the most prevalent cause of iron-deficient conditions in women. Though diagnostic of anemia is a simple task deficiency of knowledge in the area of hematology favors spreading and aggravation of anemia processes. The implementation of the register of patients with anemia syndrome into practical activities of physicians of all specialties is a modern direction of studying the given pathology. Read More

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http://dx.doi.org/10.32687/0869-866X-2018-26-6-436-439DOI Listing
November 2018
2 Reads

Combined hormonal contraceptives for heavy menstrual bleeding.

Cochrane Database Syst Rev 2019 02 11;2:CD000154. Epub 2019 Feb 11.

Department of Obstetrics and Gynaecology, University of Auckland, Private Bag 92019, Auckland, New Zealand, 1142.

Background: Menorrhagia or heavy menstrual bleeding (HMB) is an excessive blood loss that impairs a woman's quality of life, either physical, emotional, social or material. It is benign and not associated with pregnancy or any other gynaecological or systemic disease. Medical treatments used to reduce excessive menstrual blood loss (MBL) include prostaglandin synthetase inhibitors, antifibrinolytics, oral contraceptive pills, and other hormones. Read More

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http://dx.doi.org/10.1002/14651858.CD000154.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369862PMC
February 2019
6 Reads

Tranexamic Acid in Cerebral Hemorrhage: A Meta-Analysis and Systematic Review.

CNS Drugs 2019 Apr;33(4):327-336

Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.

Background: Tranexamic acid functions as an antifibrinolytic medication and is widely used to treat or prevent excessive blood loss in menorrhagia and during the perioperative period. The efficacy of tranexamic acid in reducing mortaligy and disability, and the occurrence of complications during treatment of cerebral hemorrhage remains controversial.

Objective: The objective of this systematic literature review and meta-analysis was to evaluate the efficacy and safety of tranexamic acid in patients with cerebral hemorrhage, aiming to improve the evidence-based medical knowledge of treatment options for such patients. Read More

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http://dx.doi.org/10.1007/s40263-019-00608-4DOI Listing
April 2019
4 Reads

Uterine tumor resembling ovarian sex cord tumor: a clinicopathological and immunohistochemical analysis of two cases and a literature review.

J Int Med Res 2019 Feb 8:300060518821824. Epub 2019 Feb 8.

1 Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

A uterine tumor resembling an ovarian sex cord tumor (UTROSCT) is a rare type of neoplasm that is almost thoroughly differentiated towards ovarian sex cord elements. Because of abnormal uterine bleeding, a 64-year-old postmenopausal woman received total abdominal hysterectomy with bilateral salpingo-oophorectomy. Under a microscope, the tumor cells showed an anastomosing fascicular and trabecular pattern with a reticular architecture. Read More

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http://dx.doi.org/10.1177/0300060518821824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421383PMC
February 2019
2 Reads

An Open-Label, Single-Arm, Efficacy Study of Tranexamic Acid in Adolescents with Heavy Menstrual Bleeding.

J Pediatr Adolesc Gynecol 2019 Feb 4. Epub 2019 Feb 4.

Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Study Objective: Heavy menstrual bleeding (HMB) occurs in up to 40 % of adolescent girls, significantly impacting their daily activities. Identifying alternative treatment strategies for HMB is particularly important for adolescents who prefer not to take hormonal contraception. Our objective was to determine the ability of tranexamic acid (TA) to increase health-related quality of life and decrease menstrual blood loss (MBL) in adolescents with HMB. Read More

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http://dx.doi.org/10.1016/j.jpag.2019.01.009DOI Listing
February 2019
9 Reads

A case of a severe factor XI deficiency in a Chinese woman with heavy menorrhagia.

Blood Coagul Fibrinolysis 2019 Mar;30(2):75-79

Department of Clinical Laboratory, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

: The current study was to elucidate the molecular defect in a 32-year-old Chinese woman with heavy menorrhagia and delayed wound healing. The F11 gene was amplified by PCR and screened for mutations. Then identified mutations were analyzed by in-silico programs and molecular modeling analysis. Read More

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http://Insights.ovid.com/crossref?an=00001721-201903000-0000
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http://dx.doi.org/10.1097/MBC.0000000000000795DOI Listing
March 2019
8 Reads

Hemophilia carrier's awareness, diagnosis, and management in emerging countries: a cross-sectional study in Côte d'Ivoire (Ivory Coast).

Orphanet J Rare Dis 2019 02 1;14(1):26. Epub 2019 Feb 1.

Hemostasis and Thrombosis Unit, Division of Hematology, Cliniques universitaires Saint-Luc, Brussels, Belgium.

Background: Little data is available on awareness of hemophilia carrier condition or associated bleeding risk and management in Sub-Saharan African countries. This study sought to identify hemophilia carriers in Côte d'Ivoire in order to collect data on demographics, bleeding phenotype, and laboratory results. Another purpose was to provide Ivorian hemophilia carriers with counseling on their risk of bleeding and of having children with hemophilia. Read More

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http://dx.doi.org/10.1186/s13023-019-1005-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359866PMC
February 2019
4 Reads

Pathologic Changes in Uterine Leiomyomas After Extended Treatment With Ulipristal Acetate.

Int J Gynecol Pathol 2019 Jan 29. Epub 2019 Jan 29.

Department of Pathology and Laboratory Medicine, Sinai Health System (M.C.C.) Department of Laboratory Medicine and Pathobiology, University of Toronto (M.C.C., E.L.) Department of Pathology and Laboratory Medicine, St. Michael's Hospital (E.L.), Toronto, Ontario, Canada.

Ulipristal acetate is a selective progesterone receptor modulator that acts on progesterone receptors in uterine muscle and endometrium. It is effective in reducing the size of uterine leiomyomas (fibroids) and in managing associated menorrhagia. Although ulipristal acetate-associated pathologic changes have been previously documented in the endometrium, it is unclear what morphology can be expected in posttreatment fibroids. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000581DOI Listing
January 2019
11 Reads

The Management of Heavy Menstrual Bleeding After Percutaneous Coronary Intervention in a Woman of Reproductive Age.

Front Pharmacol 2018 15;9:1573. Epub 2019 Jan 15.

Department of Pharmacy, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Heavy menstrual bleeding (HMB), previously known as menorrhagia, is in place with heavy flow and longer lasting days of bleeding during menstrual period, sequentially leading to anemia. We reported a rare case of HMB in a 33-year-old patient after percutaneous coronary intervention (PCI), who presented with acute coronary syndromes (ACS), uremia and systemic lupus erythematosus before PCI. This patient received three times of hemodialysis weekly (Monday, Wednesday, and Friday). Read More

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http://dx.doi.org/10.3389/fphar.2018.01573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341068PMC
January 2019
3 Reads

Adverse symptoms during short-term use of ulipristal acetate in women with uterine myomas and/or adenomyosis.

J Obstet Gynaecol Res 2019 Apr 24;45(4):865-870. Epub 2019 Jan 24.

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

Aim: To evaluate various adverse symptoms during short-term use of ulipristal acetate in women with uterine myomas (n = 90), adenomyosis (n = 3) or both (n = 7).

Methods: One hundred premenopausal women who received ulipristal acetate for 4-12 weeks during 2016 to 2017 were selected. The medical records were reviewed and the following information was collected; adverse symptoms during medication, presence of menorrhagia or menstrual cramps, blood hemoglobin and liver function test. Read More

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http://dx.doi.org/10.1111/jog.13917DOI Listing
April 2019
15 Reads

A Novel Case of Fibroids after Menopause.

Case Rep Obstet Gynecol 2018 25;2018:9104719. Epub 2018 Dec 25.

Consultant Obstetrician and Gynaecologist at Hereford County Hospital, Stonebow Road, Hereford, UK.

Fibroids are a condition commonly seen as part of routine gynaecological practice and generally present with menorrhagia, infertility, or pressure symptoms depending on their exact location. We report the case of a postmenopausal 57-year-old lady presenting with left-sided pain and frequency with a complex 15 cm mass mid pelvis and an adjacent additional 7 cm cyst but a risk of malignancy index suggesting benign pathology. She underwent total abdominal hysterectomy (TAH) and right-sided salpingo-oophrectomy (RSO) on recommendation of the multidisciplinary team (MDT) and histology confirmed leiomyomatosis peritonealis disseminata. Read More

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https://www.hindawi.com/journals/criog/2018/9104719/
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http://dx.doi.org/10.1155/2018/9104719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323423PMC
December 2018
7 Reads

The effect of frankincense (Boswellia serrata, oleoresin) and ginger (Zingiber officinale, rhizoma) on heavy menstrual bleeding: A randomized, placebo-controlled, clinical trial.

Complement Ther Med 2019 Feb 27;42:42-47. Epub 2018 Sep 27.

Department of Persian Medicine, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Objectives: To evaluate the effect of frankincense (Boswellia serrata, oleoresin) and ginger (Zingiber officinale, rhizoma) as complementary treatments for heavy menstrual bleeding (HMB) among women of reproductive age.

Design: Randomized, placebo-controlled, clinical trial.

Setting: Gynecology outpatient clinics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09652299183079
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http://dx.doi.org/10.1016/j.ctim.2018.09.022DOI Listing
February 2019
17 Reads

Endometrial resection and ablation techniques for heavy menstrual bleeding.

Cochrane Database Syst Rev 2019 01 22;1:CD001501. Epub 2019 Jan 22.

Department of Obstetrics and Gynaecology, University of Auckland, Park Rd, Grafton, Auckland, New Zealand, 1142.

Background: Heavy menstrual bleeding (HMB) is a significant health problem in premenopausal women; it can reduce their quality of life and can cause social disruption and physical problems such as iron deficiency anaemia. First-line treatment has traditionally consisted of medical therapy (hormonal and non-hormonal), but this is not always successful in reducing menstrual bleeding to acceptable levels. Hysterectomy is a definitive treatment, but it is more costly and carries some risk. Read More

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http://dx.doi.org/10.1002/14651858.CD001501.pub5DOI Listing
January 2019
3 Reads

Bleeding assessment in female patients with the Hermansky-Pudlak syndrome-A case series.

Eur J Haematol 2019 May 6;102(5):432-436. Epub 2019 Mar 6.

Department of Surgery, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico.

Introduction: The Hermansky-Pudlak syndrome (HPS) is an autosomal recessive rare disorder characterized by oculocutaneous albinism, bleeding diathesis, chronic granulomatous colitis and/or pulmonary fibrosis. HPS is the most common single-gene disorder in Puerto Rico with a prevalence of 1:1,800 in the Northwest of the island. Risk of menorrhagia and post-partum hemorrhage (PPH) in cases of women with HPS have been described in the medical literature, but data regarding comprehensive description of bleeding diathesis remains lacking. Read More

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http://dx.doi.org/10.1111/ejh.13210DOI Listing
May 2019
3 Reads

Oral tranexamic acid associated with platelet transfusion to prevent hemorrhage in a patient with Glanzmann thrombasthenia.

Gen Dent 2019 Jan-Feb;67(1):61-65

Glanzmann thrombasthenia (GT) is a rare genetic disorder that alters platelet function. The clinical manifestations include purpura, epistaxis, gingival bleeding, and menorrhagia. For patients with GT, conventional surgical dental treatment may result in hemorrhagic complications. Read More

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January 2019
7 Reads

Blood inflammatory and endothelial markers in women with von Willebrand disease.

PLoS One 2019 10;14(1):e0210544. Epub 2019 Jan 10.

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Introduction: VWD-affected females often experience menorrhagia. Periodical fluctuations of the sex steroids during the menstrual cycle cause changes both in the coagulation and immune system. The aim of the current study was to assess the changes in selected inflammatory and endothelial markers in women with VWD during two phases of the menstrual cycle (follicular and luteal) and to compare it with corresponding data from healthy controls. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210544PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328189PMC
January 2019
13 Reads

Menorraghia's impact on quality of life: A case control study from a teaching Hospital in Lahore.

Authors:
Lamia Yusuf

Pak J Med Sci 2018 Nov-Dec;34(6):1435-1438

Dr. Lamia Yusuf, MBBS, FCPS, MHPE. Assistant Professor (Gynaecology / Obstetrics), Rashid Latif Medical College/ Arif Memorial teaching Hospital, Lahore, Pakistany.

Background And Objective: Menorrhagia is one of the common complaints presenting in gynaecology outdoor and clinics. Menorrhagia is defined as excessive uterine bleeding occurring at regular intervals or prolonged uterine bleeding lasting for more than seven days. This is a very distressing condition effecting almost all ages, and has multiple causes. Read More

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http://dx.doi.org/10.12669/pjms.346.15410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290234PMC
December 2018
13 Reads

Missed at first Glanz: Glanzmann thrombasthenia initially misdiagnosed as Von Willebrand Disease.

Transfus Apher Sci 2019 Feb 5;58(1):58-60. Epub 2018 Dec 5.

National Coagulation Centre, St James's Hospital, Dublin 8, Ireland; Irish Centre for Vascular Biology, Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland. Electronic address:

Glanzmann thrombasthenia (GT) is an autosomal recessive bleeding disorder caused by a defect in platelet integrin αIIbβ3. Given the rarity of the condition (1/1,000,000), assessment and diagnosis should be undertaken in a specialist centre. We report the case of a 34 year old woman with severe menorrhagia and a childhood diagnosis from another centre of Von Willebrand Disease. Read More

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http://dx.doi.org/10.1016/j.transci.2018.11.008DOI Listing
February 2019
4 Reads

Factor X deficiency due to a compound heterozygosis between a new mutation (Gla72Asp) in exon 2 and an already known one (Gly154Arg) in exon 5: Factor X Mar del Plata 1).

Cardiovasc Hematol Disord Drug Targets 2018 Dec 11. Epub 2018 Dec 11.

Laboratorio de Hematologia, Sanatorio Allende y Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba. Argentina.

A compound heterozygote due to the association of a new mutation (Gla72Asp) with an already known mutation (Gly154Arg) of the FX gene is reported. The proposita is a 38 year old female who had a moderate bleeding tendency (menorrhagia, epistaxis, easy bruising). The proposita has never received substitution therapy but in the occasion of a uterine biopsy. Read More

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http://dx.doi.org/10.2174/1871529X19666181212103944DOI Listing
December 2018
1 Read

Case Report of the Successful Use of Mirena Levonorgestrel Intrauterine System in a Patient with Didelphys Uterus and Obstructed Hemivagina.

J Pediatr Adolesc Gynecol 2019 Apr 8;32(2):182-185. Epub 2018 Dec 8.

Section of Paediatric Gynaecology, Division of Endocrinology, Hospital for Sick Children, and the Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.

Background: The Mirena levonorgestrel intrauterine system (IUS; Bayer HealthCare Pharmaceuticals) is frequently used for menstrual suppression in adolescents with special needs. However, the presence of a uterine anomaly is generally considered a contraindication to IUS insertion, thereby excluding a potentially highly effective option for this patient population.

Case: A Mirena IUS was used in a medically and surgically complex special needs 14-year-old adolescent with a didelphys uterus and obstructed hemivagina. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10833188183036
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http://dx.doi.org/10.1016/j.jpag.2018.11.014DOI Listing
April 2019
16 Reads
1.812 Impact Factor

[Successful long-term management of ovarian bleeding and menorrhagia with prothrombin complex concentrate in a patient with congenital factor X deficiency].

Rinsho Ketsueki 2018;59(11):2428-2431

Department of Blood Coagulation, Ogikubo Hospital.

A female patient in her forties exhibited no evidence of abnormal bleeding at birth. At the age of 6 years, she experienced pain in bilateral thighs and knee joints without any occasion. Accordingly, the bleeding tendency was suspected, and the coagulation profile assessment revealed prolongation of the APTT (122 s). Read More

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http://dx.doi.org/10.11406/rinketsu.59.2428DOI Listing
January 2018
2 Reads

Five-year clinical outcomes of uterine artery embolization for symptomatic leiomyomas: An analysis of risk factors for reintervention.

Eur J Radiol 2018 Dec 28;109:83-87. Epub 2018 Oct 28.

Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Republic of Korea.

Objectives: The objective of this study is to investigate the five-year reintervention rate of uterine artery embolization (UAE) for symptomatic leiomyomas and to identify potential predictive factors of reintervention.

Methods: From March 2011 to February 2012, 92 consecutive women (mean age 41.9 years, range 28-55 years) underwent bilateral UAE. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183036
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http://dx.doi.org/10.1016/j.ejrad.2018.10.017DOI Listing
December 2018
4 Reads

Investigation of the contribution of an underlying platelet defect in women with unexplained heavy menstrual bleeding.

Platelets 2019 6;30(1):56-65. Epub 2018 Dec 6.

b Institute of Cardiovascular Sciences, College of Medical and Dental Sciences , University of Birmingham , Birmingham , UK.

Heavy menstrual bleeding (HMB) is often undiagnosed in women and can cause discomfort and distress. A haemostatic cause for excessive bleeding is often not routinely investigated and can lead to hysterectomy at an early age. A prospective cohort study was carried out to determine whether certain patients with unexplained HMB have an underlying platelet function defect (PFD). Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1543865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406209PMC
March 2019
15 Reads

Thrombin generation during a regular menstrual cycle in women with von Willebrand disease.

Sci Rep 2018 Nov 30;8(1):17467. Epub 2018 Nov 30.

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Fluctuations of the sex steroids during the menstrual cycle might significantly influence hemostasis. This association, derived from a number of the observations on healthy women, is yet to be described in females affected by bleeding disorders. The aim of the current study was to assess the changes in hemostatic variables in women with vWD during two phases of the menstrual cycle (follicular and luteal) and to compare it with healthy controls. Read More

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http://dx.doi.org/10.1038/s41598-018-35897-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269516PMC
November 2018
4 Reads

Evaluation and management of heavy menstrual bleeding in adolescents: the role of the hematologist.

Authors:
Sarah H O'Brien

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):390-398

Division of Pediatric Hematology/Oncology, Nationwide Children's Hospital, The Ohio State University, Columbus, OH; and.

Heavy menstrual bleeding (HMB) is frequently reported by adolescents. The role of the hematologist is threefold in evaluating such patients: (1) perform a clinical and laboratory evaluation for an underlying bleeding disorder on the basis of the degree of clinical suspicion, (2) identify and manage any concomitant iron deficiency, and (3) provide input to the referring provider regarding the management of HMB, particularly for patients with identified hemostatic defects. Several clues in the menstrual history should raise suspicion for an underlying bleeding disorder, such as menses lasting >7 days, menstrual flow which soaks >5 sanitary products per day or requires product change during the night, passage of large blood clots, or failure to respond to conventional therapies. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246024PMC
November 2018
5 Reads

The Adolescent with Menorrhagia: Diagnostic Approach to a Suspected Bleeding Disorder.

Pediatr Rev 2018 Dec;39(12):588-600

Department of Pediatrics, Holtz Children's Hospital-Jackson Memorial Medical Center, Miami, FL.

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http://dx.doi.org/10.1542/pir.2017-0105DOI Listing
December 2018
4 Reads

Bleeding Disorders in Adolescents with Heavy Menstrual Bleeding: The Queensland Statewide Paediatric and Adolescent Gynaecology Service.

J Pediatr Adolesc Gynecol 2019 Apr 22;32(2):122-127. Epub 2018 Nov 22.

Statewide Paediatric and Adolescent Gynaecology Service, Royal Brisbane and Women's Hospital and Lady Cilento Children's Hospital, Brisbane, Queensland, Australia; University of Queensland, Faculty of Medicine, Brisbane, Queensland, Australia.

Study Objective: Heavy menstrual bleeding (HMB) is a common gynecological complaint among young women with up to 40% having experienced HMB. Bleeding disorders are increasingly being recognized in adolescents and young adults with HMB. The aim of this study was to determine the prevalence of bleeding disorders in adolescents with HMB, among patients who presented to the Queensland Statewide Paediatric and Adolescent Gynaecology Service between July 2007 and July 2017. Read More

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http://dx.doi.org/10.1016/j.jpag.2018.11.005DOI Listing
April 2019
4 Reads