6,070 results match your criteria Menorrhagia


Incidence of abnormal uterine bleeding in a multicenter implementation study using apixaban and rivaroxaban to treat venous thromboembolism.

Thromb Res 2021 May 26;204:29-31. Epub 2021 May 26.

Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America. Electronic address:

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Phase III long-term study to evaluate the efficacy and safety of ulipristal acetate in Japanese patients with uterine fibroids.

J Obstet Gynaecol Res 2021 Jun 9. Epub 2021 Jun 9.

Clinical Development Department, ASKA Pharmaceutical Co., Ltd., Tokyo, Japan.

Aim: To assess the efficacy and safety of long-term intermittent administration of 10-mg ulipristal acetate (UPA) for symptomatic uterine fibroids in Japanese women.

Methods: Open-label, noncomparative study (Japan Primary Registries Network identifier: JapicCTI-173737) conducted at 32 gynecological centers (November 2017-December 2019). Premenopausal women diagnosed with uterine fibroids associated with heavy menstrual bleeding received three 12-week courses of 10-mg UPA once daily. Read More

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Long-term follow up of carbohydrate metabolism and adverse events after termination of Omnitrope® treatment in children born small for gestational age.

Ther Adv Endocrinol Metab 2021 5;12:20420188211013121. Epub 2021 May 5.

Sandoz Biopharmaceuticals, Hexal AG, Industriestr. 18/5, Holzkirchen D-83607, Germany.

Background: Recombinant human growth hormone (rhGH) therapy can affect carbohydrate metabolism and lead to impaired glucose tolerance during treatment. In addition, short children born small for gestational age (SGA) are predisposed to metabolic abnormalities. This study assessed the long-term safety of rhGH (Omnitrope®) use in short children born SGA. Read More

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Efficacy of ulipristal acetate in women with fibroid induced menorrhagia: A systematic review and meta-analysis.

J Gynecol Obstet Hum Reprod 2021 May 31:102173. Epub 2021 May 31.

University of Aberdeen, School of Medicine, Medical Sciences and Nutrition, Aberdeen, United Kingdom, AB25 2ZD.

Aim: To evaluate the efficacy of UPA in women with fibroid induced menorrhagia.

Methods: Embase, MEDLINE, CAB Abstracts, Cochrane Central Register of Controlled Trials, PsychInfo were searched up to 18th May 2020 and updated on 7th February 2021. Randomised controlled trials evaluating the efficacy of UPA in women with fibroid induced menorrhagia we included in the study. Read More

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How prevalent are symptoms and risk factors of pelvic inflammatory disease in a sexually conservative population.

Reprod Health 2021 May 28;18(1):109. Epub 2021 May 28.

School of Medicine, The University of Jordan, Amman, Jordan.

Background: Pelvic inflammatory disease (PID) is the inflammation of the adnexa of the uterus, that mainly manifests in a subclinical/chronic context and goes largely underreported. However, it poses a major threat to women's health, as it is responsible for infertility and ectopic pregnancies, as well as chronic pelvic pain. Previous studies in Jordan have not reported PID, attributed mainly to the social structure of the country which largely represents a sexually conservative population. Read More

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Gynaecological and reproductive health of women with telomere biology disorders.

Br J Haematol 2021 May 21. Epub 2021 May 21.

National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.

Reproductive health may be adversely impacted in women with dyskeratosis congenita (DC) and related telomere biology disorders (TBD). We evaluated gynaecological problems, fertility, and pregnancy outcomes in 39 females aged 10-81 years who were followed longitudinally in our DC/TBD cohort. Twenty-six had bone marrow failure and 12 underwent haematopoietic cell transplantation. Read More

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Sonographic and clinical features of adenomyosis in women in "early" (18-35) and "advanced" (>35) reproductive ages.

Minerva Obstet Gynecol 2021 Jun;73(3):354-361

Department of Maternal and Child Health and Urological Sciences, Umberto I Polyclinic, Sapienza University, Rome, Italy.

Background: Adenomyosis has been considered for a long time a condition of advanced reproductive age. Recently, imaging techniques have allowed its diagnosis in young women. The aim of our study was to compare adenomyosis in early (18-35) and advanced (>35) reproductive age (ERA vs. Read More

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The treatment with Levonorgestrel Releasing Intrauterine System (LNG-IUS) in patients affected by menometrorrhagia, dysmenorrhea and adenomimyois: clinical and ultrasonographic reports.

Eur Rev Med Pharmacol Sci 2021 May;25(9):3432-3439

Department of Surgical and Medical Sciences and Translational Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy.

Objective: Adenomyosis is the consequence of the myometrial invasion by endometrial glands and stroma. Transvaginal ultrasonography plays a decisive role in the diagnosis and monitoring of this pathology. Our study aims to evaluate the efficacy of LNG-IUS (Levonorgestrel Releasing Intrauterine System) as medical therapy. Read More

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Estetrol-Drospirenone Combination Oral Contraceptive: North American Phase 3 Efficacy and Safety Results.

Contraception 2021 May 14. Epub 2021 May 14.

Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia, USA.

Objective: To assess efficacy, cycle control, and safety of an oral contraceptive containing estetrol (E4) 15mg and drospirenone (DRSP) 3mg.

Study Design: Women aged 16-50 years with a body mass index ≤35 kg/m enrolled in this multicenter, open-label, 13-cycle, phase 3 trial evaluating E4/DRSP in a 24-active/4-placebo regimen. Follow-up was scheduled at Cycles 2, 4, 7, and 10 and within 3 weeks of completing cycle 13. Read More

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Elevated von Willebrand factor levels during heavy menstrual bleeding episodes limit the diagnostic utility for von Willebrand disease.

Res Pract Thromb Haemost 2021 May 4;5(4):e12513. Epub 2021 May 4.

Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta Emory University Atlanta GA USA.

Background: Heavy menstrual bleeding (HMB) is often the first bleeding symptom for female individuals with inherited bleeding disorders. Guidelines recommend performing the hemostatic evaluation at HMB presentation. Von Willebrand factor (VWF) levels increase with stress, making it unclear if VWF studies during acute bleeding are beneficial in diagnosing von Willebrand disease (VWD). Read More

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Management of surgery, menorrhagia and child-birth for patients with unclassified bleeding disorders: a systematic review of cohort studies.

Blood Coagul Fibrinolysis 2021 May 10. Epub 2021 May 10.

Haemostasis and Thrombosis Centre, Guy's and St Thomas' NHS Foundation Trust, London Department of Clinical Haematology, Oxford University Hospitals NHS Foundation Trust Radcliffe Department of Medicine, University of Oxford, Oxford Cardiff Haemophilia Centre, University Hospital of Wales Comprehensive Care Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham Systematic Review Initiative, NHS Blood and Transplant, Oxford Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Unclassified bleeding disorders account for 2.6% of all new bleeding disorder registrations in the UK. The management of the bleeding phenotype associated with these disorders is poorly described. Read More

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Inherited Platelet Disorders: An Updated Overview.

Int J Mol Sci 2021 Apr 26;22(9). Epub 2021 Apr 26.

Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, CIBERER-U765, 30008 Murcia, Spain.

Platelets play a major role in hemostasis as ppwell as in many other physiological and pathological processes. Accordingly, production of about 10 platelet per day as well as appropriate survival and functions are life essential events. Inherited platelet disorders (IPDs), affecting either platelet count or platelet functions, comprise a heterogenous group of about sixty rare diseases caused by molecular anomalies in many culprit genes. Read More

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Clitoromegaly, Vulvovaginal Hemangioma Mimicking Pelvic Organ Prolapse, and Heavy Menstrual Bleeding: Gynecologic Manifestations of Klippel-Trénaunay Syndrome.

Medicina (Kaunas) 2021 Apr 9;57(4). Epub 2021 Apr 9.

Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea.

Klippel-Trénaunay Syndrome (KTS) is a genetic vascular malformation involving the capillary, lymphatic, and venous channels. Prenatal sonographic diagnosis of KTS with an enlarged fetal limb is well-known; however, postnatal gynecologic manifestations are rarely reported. KTS can cause clitoromegaly, vulvovaginal hemangioma, and heavy menstrual bleeding. Read More

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[Congenital factor Ⅺ deficiency: a retrospective analysis of 80 cases].

Zhonghua Xue Ye Xue Za Zhi 2021 Mar;42(3):205-209

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

To analyze the clinical manifestation, laboratory examination, treatment and prognosis of congenital factor Ⅺ (FⅪ) deficiency. The clinical data of 80 patients with congenital FⅪ deficiency in our hospital from September 2006 to October 2020 were analyzed retrospectively. Among the 80 patients, there were 33 males (41. Read More

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Cryptogenic new-onset refractory status epilepticus (NORSE) following blood transfusion in a patient with severe anemia.

Epileptic Disord 2021 Apr;23(2):403-406

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.

New-onset refractory status epilepticus (NORSE) is a rare neurological emergency in which a patient without prior seizure disorder develops seemingly unprovoked status epilepticus refractory to treatment. We report the case of a middle-aged woman who developed NORSE after receiving multiple blood transfusions for subacute blood loss anemia secondary to menorrhagia. Although the mechanism is unclear, we propose that sudden changes in blood viscosity and vasogenic tone resulted in cortical edema and irritation. Read More

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Precocious pseudo-puberty in a 2-year-old girl, presenting with bilateral ovarian enlargement and progressing to unilateral juvenile granulosa cell tumour.

J Clin Res Pediatr Endocrinol 2021 Apr 14. Epub 2021 Apr 14.

Glasgow University School of Medicine, Glasgow, United Kingdom.

Ovarian causes of precocious pseudo-puberty (PPP) include McCune-Albright syndrome (MAS) and juvenile granulosa cell tumour (JGCT). We describe a case of PPP in which bilateral ovarian enlargement with multiple cysts progressed to unilateral JGCT. A girl aged 2. Read More

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Prospective associations between physical activity and BMI with irregular periods and heavy menstrual bleeding in a large cohort of Australian women.

Hum Reprod 2021 05;36(6):1481-1491

Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane St Lucia, QLD, Australia.

Study Question: Are physical activity (PA) and body mass index (BMI) associated with irregular periods and heavy menstrual bleeding (HMB) in Australian women?

Summary Answer: Overweight and obese women have higher odds of both irregular periods and HMB than underweight/normal-weight women, but high levels of PA reduce the odds of HMB.

What Is Known Already: Most studies on relationships between PA and menstrual problems have focused on female athletes, but there have been few population-based studies.

Study Design, Size, Duration: Prospective cohort study, 10618 participants in the Australian Longitudinal Study of Women's Health (ALSWH) who completed mailed surveys in 1996, with follow-ups in 2000, 2003, 2006, 2009, 2012, and 2015. Read More

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Emerging Roles of Long Non-coding RNAs in Uterine Leiomyoma Pathogenesis: a Review.

Reprod Sci 2021 Apr 12. Epub 2021 Apr 12.

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Koodakyar St., Velenjak Ave, Chamran Highway, Tehran, Iran.

Uterine leiomyoma (UL), as the most prevalent type of women's health disorders, is a benign tumor that originates from the smooth muscle cell layer of the uterus. A great number of associated complications are observed including infertility, miscarriage, bleeding, pain, dysmenorrhea, menorrhagia, and dyspareunia. Although the etiology of UL is largely undefined, environmental and genetic factors are witnessed to engage in the UL development. Read More

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The Impact of the COVID-19 Pandemic on Women's Reproductive Health.

Front Endocrinol (Lausanne) 2021 22;12:642755. Epub 2021 Mar 22.

Faculty of Health Sciences, School of Medicine, Trinity College Dublin, Dublin, Ireland.

Background: The COVID-19 pandemic has profoundly affected the lives of the global population. It is known that periods of stress and psychological distress can affect women's menstrual cycles. We therefore performed an observational study of women's reproductive health over the course of the pandemic thus far. Read More

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Effectiveness and Safety of Moxibustion Robots on Primary Dysmenorrhea: A Randomized Controlled Pilot Trial.

Chin J Integr Med 2021 Apr 10. Epub 2021 Apr 10.

Department of Acupuncture and Rehabilitation, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.

Objective: To conduct a pilot trial to explore the effectiveness and safety of moxibustion robots in treating primary dysmenorrhea (PD) and evaluate its feasibility in clinic.

Methods: A total of 70 participants with PD were allocated to either moxibustion robot (MR) group (35 cases) or manual moxibustion (MM) group (35 cases) using computer-generated randomization. One acupoint Guanyuan (CV 4) was selected to receive moxa heat stimulation. Read More

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Obesity is associated with heavy menstruation that may be due to delayed endometrial repair.

J Endocrinol 2021 May;249(2):71-82

MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.

Heavy menstrual bleeding is common and debilitating but the causes remain ill defined. Rates of obesity in women are increasing and its impact on menstrual blood loss (MBL) is unknown. Therefore, we quantified BMI and MBL in women not taking hormones and with regular menstrual cycles and revealed a positive correlation. Read More

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Two Novel Mutations in a Turkish Patient with Acute Myeloid Leukemia.

Balkan J Med Genet 2020 Nov 23;23(2):99-102. Epub 2021 Mar 23.

Department of Medical Genetics, Pamukkale University, Denizli, Turkey.

Acute myeloid leukemia (AML) was first categorized in 1976 by French, American and British researchers, and divided into eight subgroups (M0 to M7), depending on the cytochemical or histological changes in the leukemic cells. The gene mutations of , and are the most common that cooperate together in the prognosis of AML. The gene that is a hematopoietic transcription factor, is located on chromosome 19q13. Read More

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November 2020

Immune Thrombocytopenic Purpura in a Patient With SARS-CoV-2 and Epstein-Barr Virus.

Cureus 2021 Feb 28;13(2):e13615. Epub 2021 Feb 28.

Internal Medicine, University of Texas Medical Branch, Galveston, USA.

A 35-year-old female was admitted to the hospital for menorrhagia and fatigue. Initial labs revealed that the patient had severe thrombocytopenia and also tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The main objective in this case is to describe the investigation that eventually led to a diagnosis of idiopathic thrombocytopenic purpura (ITP) in the setting of a SARS-CoV-2 coronavirus disease 2019 (COVID-19) infection and co-infection with Epstein-Barr virus (EBV). Read More

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February 2021

Initial experience with HydroPearl microspheres for uterine artery embolization for the treatment of symptomatic uterine fibroids.

CVIR Endovasc 2021 Mar 31;4(1):32. Epub 2021 Mar 31.

Division of Vascular and Interventional Radiology, Department of Radiology, University of North Carolina School of Medicine, 2017 Old Clinic Bldg CB #7510, Chapel Hill, NC, 27599-7510, USA.

Background: Uterine Artery Embolization (UAE) is a minimally invasive procedure used to treat symptomatic uterine fibroids. The HydroPearl Microsphere (Terumo Interventional Systems) is an embolic agent approved for UAE and other embolization procedures. The purpose of this article is to describe our initial experience with HydroPearl for UAE in patients with symptomatic uterine fibroids. Read More

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Nutcracker Phenomenon with Menorrhagia in a Woman with Marfan Syndrome.

Ann Vasc Dis 2021 Mar;14(1):88-91

Department of Cardiovascular Surgery, Tokyo Medical University Hospital, Tokyo, Japan.

Nutcracker phenomenon (NCP) refers to left renal vein compression at the superior mesenteric artery origin involving hematuria and dysuria due to the compression of the renal venous return and pelvic congestion syndrome caused by the compression of the gonadal venous return. A leptosomatic woman (body mass index, 19 kg/m) presented with NCP and Marfan syndrome accompanied by severe menorrhagia. Vascular ultrasonography revealed reversed flow in the left ovarian vein. Read More

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18F-FDG PET/CT in Uterine Follicular Dendritic Cell Sarcoma.

Clin Nucl Med 2021 Mar 16. Epub 2021 Mar 16.

From the Department of PET/CT, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.

Abstract: A 46-year-old woman presented with menorrhagia, abdominal distension, and neck mass for 3 months. Ultrasonography detected a large intra-abdominal mass and enlarged neck lymph nodes. Further 18F-FDG PET/CT scan revealed lesions with intense 18F-FDG avidity in abdominal cavity and neck. Read More

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Effect Of Justicia Adhatoda (Malabar Nut) Leaf Extract On Drug-Induced Coagulopathy In Mice And In-Vitro Platelet Aggregation Of Human Blood.

J Ayub Med Coll Abbottabad 2021 Jan-Mar;33(1):3-8

Department of Pharmacology, CMH Medical College, Lahore.

Background: Justicia adhatoda is widely used in traditional medicine for treatment of menorrhagia, piles and bleeding disorders. Oral antiplatelet and anticoagulant drugs are routinely prescribed to patients with cardiovascular diseases. These drugs have one major adverse effect that they can cause spontaneous haemorrhage, which can be fatal. Read More

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Office hysteroscopy safety and feasibility in women receiving anticoagulation and anti-platelet treatment.

Eur J Obstet Gynecol Reprod Biol 2021 May 17;260:110-113. Epub 2021 Mar 17.

Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.

Objectives: More than 60,000 hysteroscopies are performed every year in the UK for common reasons such as heavy menstrual bleeding (HMB) or postmenopausal bleeding. A significant number of women requiring hysteroscopy receive oral anticoagulants and there is often a reluctance to perform these procedures due to bleeding concerns.

Study Design: We are presenting the first proof of concept cohort of patients undergoing minor hysteroscopic procedures while on anticoagulant or antiplatelet medication. Read More

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