5,892 results match your criteria Menorrhagia


Prospective Evaluation of ISTH-BAT as a Predictor of Bleeding Disorder in Adolescents Presenting with Heavy Menstrual Bleeding in a Multidisciplinary Hematology Clinic.

J Thromb Haemost 2020 Jul 12. Epub 2020 Jul 12.

Department(s) of Pediatrics, Division of Hematology/Oncology, Children's Medical Center, The University of Texas Southwestern Medical Center, TX, Pathology and Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Dallas, TX, United States.

Background: Heavy menstrual bleeding (HMB) can be the first manifestation of an undiagnosed bleeding disorder (BD). Identifying a BD can be challenging in the adolescent age group. The utility of bleeding assessment tools (BAT) remains elusive in this population. Read More

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http://dx.doi.org/10.1111/jth.14997DOI Listing

Molecular and clinical profile of congenital fibrinogen disorders in Iran, identification of two novel mutations.

Int J Lab Hematol 2020 Jul 8. Epub 2020 Jul 8.

Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Congenital fibrinogen disorders (CFDs) comprise the quantitative and qualitative fibrinogen molecule abnormalities that are caused by fibrinogen gene mutations. The objective of this cohort research was to study the molecular and clinical profiles of patients with CFDs.

Materials And Methods: Genomic DNA Sanger sequencing of 14 Iranian patients was performed to determine CFDs-causing mutations. Read More

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http://dx.doi.org/10.1111/ijlh.13258DOI Listing

Successful treatment of refractory secondary immune thrombocytopenia (antiphospholipid antibody syndrome-associated) with the combination of rituximab and romiplostim at the cost of severe bone pain: A case report and review of literature.

J Oncol Pharm Pract 2020 Jul 1:1078155220935490. Epub 2020 Jul 1.

Department of Internal Medicine, Istanbul University-Cerrahpasa Faculty of Medicine, Istanbul, Turkey.

Introduction: Immune thrombocytopenia is an autoimmune disorder associated with increased thrombocyte destruction and impaired production in the bone marrow. Proposed mechanisms include an antibody or autoreactive T-cell-associated autoimmunity and thrombopoietin deficiency among others. Clinical manifestations are predominantly mucocutaneous hemorrhages including petechiae, purpura, mucosal bleeding in the urinary or the gastrointestinal tracts, menorrhagia, and epistaxis. Read More

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http://dx.doi.org/10.1177/1078155220935490DOI Listing

Outpatient Management of Heavy Menstrual Bleeding in Adolescent and Young Women with Inherited Platelet Function Disorders.

J Pediatr Adolesc Gynecol 2020 Jun 28. Epub 2020 Jun 28.

Michigan Medicine, Ann Arbor, MI; Department of Pediatrics, Division of Hematology and Oncology.

Study Objective: To assess the treatment patterns and efficacy of hormonal (HM) and non-hormonal (NHM) management of heavy menstrual bleeding (HMB) in young women with inherited platelet function disorders (IPFD).

Design: /Setting/Participants: A retrospective chart review was performed of outpatient treatment of HMB in females age 9-25 years old diagnosed with IPFDs referred to gynecology and/or hematology at a tertiary care hospital between 2006 and 2018.

Intervention: Study sample was identified using billing codes for IPFD. Read More

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http://dx.doi.org/10.1016/j.jpag.2020.06.019DOI Listing

Symptom related to Essure® and evolution after removal: outcomes of retrospective cohort.

J Gynecol Obstet Hum Reprod 2020 Jun 23:101836. Epub 2020 Jun 23.

CHU Lille, Gynaecological Surgery Department, F-59000, Lille, France. Electronic address:

Introduction: The number of requests for Essure removal has grown continually over recent years. The objective is to describe the symptoms reported after Essure sterilization, methods of removal and results.

Material And Methods: Retrospective and single-centre cohort (Regional university hospital of Lille, France) was conducted. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101836DOI Listing

Standardizing Care to Manage Bleeding Disorders in Adolescents with Heavy Menses-A Joint Project from the ISTH Pediatric/Neonatal and Women's Health SSCs.

J Thromb Haemost 2020 Jun 23. Epub 2020 Jun 23.

Pediatric Hematology/Oncology Unit, Shaare Zedek Medical Center, Hebrew University Medical School, Jerusalem, Israel.

Background: Bleeding disorders (BD) are under-recognized in adolescents with heavy menstrual bleeding (HMB).

Objectives: The lack of clinical guidelines and variable symptomatic management of HMB created the imperative to standardize HMB care to identify and manage BD in adolescents.

Methods: We convened an international working group (WG), utilized the results of a literature review to define knowledge gaps in HMB care, and used the collective clinical experience of the WG to develop care considerations for adolescents with BD and HMB. Read More

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http://dx.doi.org/10.1111/jth.14974DOI Listing

Adjuvant therapy of Chinese herbal medicine for the treatment of adenomyosis: A protocol for systematic review.

Medicine (Baltimore) 2020 Jun;99(25):e20560

Department of Gynecology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu.

Background: Adenomyosis is benign gynecologic condition with complex etiologies. Common symptoms associated with adenomyosis (AM) include menorrhagia, dysmenorrhea, chronic pelvic pain, metrorrhagia, and dyspareunia. Although Chinese herbal medicine (CHM) has often been utilized for managing AM in clinical practice in China, evidence regarding its efficacy is lacking. Read More

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http://dx.doi.org/10.1097/MD.0000000000020560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310900PMC

Effect of CYP3A inducer/inhibitor on pharmacokinetics of five alkaloids in Evodiae Fructus.

Chem Biol Interact 2020 Jun 17;327:109146. Epub 2020 Jun 17.

School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, China. Electronic address:

Evodiae Fructus (EF), the dried nearly mature scented fruit of Tetradium ruticarpum (A.Juss.) T. Read More

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http://dx.doi.org/10.1016/j.cbi.2020.109146DOI Listing

Thyroid Dysfunction in Patients with Abnormal Uterine Bleeding in a Tertiary Care Hospital: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2020 May 30;58(225):333-337. Epub 2020 May 30.

Department of Obstetrics and Gynecology, KIST Medical College, Imadol, Nepal.

Introduction: Abnormal uterine bleeding is a common gynecological presentation, accounting for at least 20% of all new outpatient visits. It has been recognized that thyroid dysfunction may have profound effects on the female reproductive system. Both hypothyroidism and hyperthyroidism are associated with a variety of changes, including delayed onset of puberty, anovulatory cycles, and abnormally high fetal wastage. Read More

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http://dx.doi.org/10.31729/jnma.5033DOI Listing

[Congenital factor Ⅶ deficiency: a retrospective analysis of 43 cases].

Zhonghua Xue Ye Xue Za Zhi 2020 May;41(5):394-398

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

To explore the pathogenesis, clinical characteristics, laboratory findings, diagnosis, treatment, and prognosis of congenital factor Ⅶ (FⅦ) deficiency. Clinical data of 43 patients with congenital FⅦ deficiency diagnosed from April 1999 to September 2019 were retrospectively analyzed. There were 27 females and 16 males. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.05.006DOI Listing

Progestogen-releasing intrauterine systems for heavy menstrual bleeding.

Cochrane Database Syst Rev 2020 06 12;6:CD002126. Epub 2020 Jun 12.

Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand.

Background: Heavy menstrual bleeding (HMB) impacts the quality of life of otherwise healthy women. The perception of HMB is subjective and management depends upon, among other factors, the severity of the symptoms, a woman's age, her wish to get pregnant, and the presence of other pathologies. Heavy menstrual bleeding was classically defined as greater than or equal to 80 mL of blood loss per menstrual cycle. Read More

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http://dx.doi.org/10.1002/14651858.CD002126.pub4DOI Listing

Age at menarche, menstrual characteristics, and its associated morbidities among secondary school students in Abakaliki, southeast Nigeria.

Heliyon 2020 May 26;6(5):e04018. Epub 2020 May 26.

Department of Obstetrics & Gynaecology, Federal Teaching Hospital, P.M.B 102, Abakaliki, Ebonyi state, Nigeria.

Background: Menstruation has a variable pattern. Knowledge of age at menarche and providing accurate information to adolescent girls is necessary to allay anxiety, treat menstrual morbidities, and improve their quality of life.

Objective: To determine the age at menarche and menstrual characteristics of adolescent secondary school girls in Abakaliki. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268279PMC

A Morphometric Analysis of Platelet Dense Granules of Patients with Unexplained Bleeding: A New Entity of Delta-Microgranular Storage Pool Deficiency.

J Clin Med 2020 Jun 4;9(6). Epub 2020 Jun 4.

Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA.

One thousand and eighty patients, having prolonged bleeding times, frequent epistaxis, menorrhagia or easy bruising or other bleeding manifestations, and excluding those with von Willebrand's disease, were evaluated for platelet dense granule deficiency. The mean diameter of platelet dense granules was determined for all patients using image analysis. Four hundred and ninety-nine had "classic" dense (delta) granule storage pool deficiency (δ-SPD). Read More

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http://dx.doi.org/10.3390/jcm9061734DOI Listing

Autoimmune progesterone dermatitis as a clue to refractory jaundice in a young lady.

Clin Exp Dermatol 2020 Jun 8. Epub 2020 Jun 8.

Departments of Internal Medicine, IQRAA International Hospital and Research Centre, Calicut, 673009, Kerala, India.

A lady in her 20s presented to the emergency department with profound icterus which had not resolved with standard hepato-protective measures (ursodeoxycholic acid, cholestyramine, N-acetyl cysteine). She had nausea, malaise and intense pruritus all over the body. Drug history revealed the intake of progesterone (norethisterone acetate, 5mg/day) for menorrhagia one week prior to the development of the icterus. Read More

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http://dx.doi.org/10.1111/ced.14332DOI Listing

Two-Pronged Treatment of Hemoperitoneum and Abnormal Uterine Bleeding in an Adolescent Girl With Congenital Fibrinogen Deficiency.

Front Med (Lausanne) 2020 21;7:181. Epub 2020 May 21.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

If a woman suffers from congenital fibrinogen deficiency (CFD), she might undergo hypermenorrhea monthly and possibly to suffer from hemoperitoneum due to a ruptured follicle or corpus luteal cyst every month, which seriously threaten her health and quality of life. Here, we creatively used a combination of the levonorgestrel-releasing intrauterine system (LNG-IUS) and the combined oral contraceptives (COC) for a girl with CFD. A 14-year-old girl presented with no obvious cause of persistent and severe lower abdominal pain that began 8 h prior. Read More

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http://dx.doi.org/10.3389/fmed.2020.00181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253637PMC

Ultrasound and clinical characteristics of uterine smooth muscle tumors of uncertain malignant potential (STUMPs).

Eur J Obstet Gynecol Reprod Biol 2020 Aug 25;251:167-172. Epub 2020 May 25.

Department of Surgical Science, Università Degli Studi Di Torino, Italy.

Objective(s): Smooth muscle tumors of uncertain malignant potential are rare uterine neoplasms. Their identification through imaging is still limited due to the few available descriptions in the scientific literature. The objective of this paper is to provide clinical and ultrasound features that could support an early identification of these neoplasms. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.040DOI Listing

Iron Deficiency Anemia: An Unexpected Cause of an Acute Occipital Lobe Stroke in an Otherwise Healthy Young Woman.

Cureus 2020 Apr 27;12(4):e7852. Epub 2020 Apr 27.

Library Science, Abington Hospital-Jefferson Health, Abington, USA.

A 29-year-old caucasian woman who presented to the hospital with an acute onset of right eye visual disturbance and headache was found to have an acute left occipital lobe infarction. Past medical history was significant for iron deficiency anemia (IDA) secondary to menorrhagia. Her initial hemoglobin level was 7. Read More

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http://dx.doi.org/10.7759/cureus.7852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255072PMC

Long-term efficacy and feasibility of levonorgestrel-releasing intrauterine device use in patients with adenomyosis.

Medicine (Baltimore) 2020 May;99(22):e20421

Department of Obstetrics and Gynecology.

To evaluate the efficacy and feasibility of levonorgestrel-releasing intrauterine device (LNG-IUD) use longer than 5 years in women with adenomyosis.Data were retrospectively collected from patients who were treated with LNG-IUD longer than 5 years at the Chungnam National University hospital for adenomyosis diagnosed with ultrasonography from January 2006 to November 2013.A total of 131 patients who were diagnosed with adenomyosis had treated with LNG-IUD longer than 5 years. Read More

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http://dx.doi.org/10.1097/MD.0000000000020421DOI Listing

Women and girls with heavy menstrual bleeding and inherited bleeding disorders: A call to action for the Haemophilia Treatment Centre Nurse.

Haemophilia 2020 May 29. Epub 2020 May 29.

Royal Free Hospital, London, UK.

Over the last several decades, the increasing focus on women with inherited bleeding disorders (WBD) has brought more patients into Haemophilia Treatment Centres (HTC) around the world. These women present with unique challenges including a significant risk of heavy menstrual bleeding (HMB). The influx of a new patient group has necessitated expansion of the services provided by the multi-disciplinary team in HTCs. Read More

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http://dx.doi.org/10.1111/hae.14019DOI Listing

Elagolix for Fibroid-Associated Heavy Menstrual Bleeding. Reply.

N Engl J Med 2020 05;382(21):2066

SUNY Downstate Health Sciences University, Brooklyn, NY.

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http://dx.doi.org/10.1056/NEJMc2003851DOI Listing

Elagolix for Fibroid-Associated Heavy Menstrual Bleeding.

N Engl J Med 2020 05;382(21):2066

Weill Cornell Medicine, New York, NY

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http://dx.doi.org/10.1056/NEJMc2003851DOI Listing

Diffuse Leiomyomatosis: Complete Myomectomy for Innumerable Small Nodules to Achieve Fertility Sparing and Childbearing.

Authors:
Ikuo Konishi

Surg J (N Y) 2020 May 29;6(Suppl 1):S50-S57. Epub 2019 Aug 29.

National Hospital Organization, Kyoto Medical Center, Kyoto, Japan.

Diffuse leiomyomatosis is a rare condition among benign smooth muscle neoplasms of the uterus, being defined as innumerable small myomatous nodules that mainly occur in the submucosal area. Young women with this disease suffer from menorrhagia, pains, and infertility. It is essential to perform extensive myomectomy after opening the endometrial cavity by a deep, median, longitudinal incision of the uterine corpus, followed by careful suture and reconstruction of the uterus for fertility spearing and childbearing in young women with this disease. Read More

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http://dx.doi.org/10.1055/s-0039-1693709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214083PMC

Peculiar Congenital Factor VII Defect with the Proposita and Her Mother Showing the Same Compound Heterozygosity for Thr384Met and Arg413Gln.

Acta Haematol 2020 May 12:1-5. Epub 2020 May 12.

Bioquimica Clinica, Universidad Fasta, Mar del Plata, Argentina.

Objective: To investigate a family with factor VII (FVII) deficiency from Argentina.

Patients And Methods: The proposita is a 14-year-old girl who presented with a mild to moderate bleeding tendency. Menorrhagia is controlled with periodical administration of small doses of recombinant FVII concentrate. Read More

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http://dx.doi.org/10.1159/000507071DOI Listing

Bleeding symptoms in patients diagnosed as type 3 Von Willebrand Disease: results from 3WINTERS-IPS, an international and collaborative cross-sectional study.

J Thromb Haemost 2020 May 7. Epub 2020 May 7.

Hematology and Transfusion Medicine, L. Sacco University Hospital, Department of Oncology and Oncohematology, University of Milan, Milano, Italy.

Background: Type 3 von Willebrand's disease (VWD) patients present markedly reduced levels of von Willebrand factor and factor VIII. Because of its rarity, the bleeding phenotype of type 3 VWD is poorly described, as compared to type 1 VWD.

Aims: To evaluate the frequency and the severity of bleeding symptoms across age and sex groups in type 3 patients and to compare these with those observed in type 1 VWD patients; to investigate any possible clustering of bleeding symptoms within type 3 patients. Read More

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http://dx.doi.org/10.1111/jth.14886DOI Listing

Gynecological and obstetric outcome in the French cohort of women with factor XIII deficiency.

Thromb Res 2020 Jul 21;191:22-25. Epub 2020 Apr 21.

Hospices Civils de Lyon, Unité Hémostase Clinique, Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, France.

Introduction: Congenital factor XIII deficiency is a very rare bleeding disorder affecting 33 patients in France. Besides its role in fibrin clot stabilization, factor XIII is involved in placental attachment. Fetal miscarriages represent a frequent and concerning issue for these patients. Read More

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http://dx.doi.org/10.1016/j.thromres.2020.04.010DOI Listing

Progesterone vaginal ring as a new contraceptive option for lactating mothers: Evidence from a multicenter non-randomized comparative clinical trial in India.

Contraception 2020 May 1. Epub 2020 May 1.

Government Medical College, SMGS Hospital, Jammu, India; Postgraduate Institute of Medical Education and Research Chandigarh, India; Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India; All India Institute of Medical Sciences, New Delhi, India; K.G. Medical University, Lucknow, India; Motilal Nehru Medical College and Hospital, Prayagraj, India; GSVM Medical College and Hospital, Kanpur, India; SMS Medical College and Zanana Hospital, Jaipur, India; Institute of Obstetrics and Gynecology, Madras Medical College, Chennai, India; Government Medical College and SAT Hospital, Thiruvananthapuram, India; Jawaharlal Nehru Medical College and Hospital, Belagavi, India; Patna Medical College and Hospital, Patna, India; R.G. Kar Medical College and Hospital, Kolkata, India; Medical College and Eden Hospital, Kolkata, India; SCB Medical College and Hospital, Cuttack, India; Seth GS Medical College and KEM Hospital, Mumbai, India; KEM Hospital, Pune, India; Grant Medical College and Sir JJ Group of Hospitals, Mumbai, India; Goa Medical College and Hospital, Goa, India; Indian Council of Medical Research - National Institute for Research in Reproductive Health, Mumbai, India.

Objectives: Evaluate and compare contraceptive efficacy, safety, continuation rates and duration of lactational amenorrhea (LA) in married lactating women (20-35 years) using the progesterone vaginal ring (PVR) or Copper-T380A intrauterine device (IUD) during the first postpartum year.

Study Design: We conducted a one-year multicenter, non-randomized, non-inferiority, open-label, comparative trial at 20 centers in India and compared efficacy, safety, continuation and LA plus feeding patterns and growth/well-being of participants' infants. Women used four 3-month PVRs consecutively (lost PVRs were not replaced) and were to breastfeed at least four times/day. Read More

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http://dx.doi.org/10.1016/j.contraception.2020.04.016DOI Listing

Spontaneous Sexual Development and Heavy Menstrual Bleeding in 45,X Monosomy and 45,X/47,XXX Mosaic Turner Syndrome and a Review of the Literature.

J Pediatr Adolesc Gynecol 2020 Apr 18. Epub 2020 Apr 18.

Department of Pediatrics, School of Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea. Electronic address:

Turner syndrome (TS) is one of the most common sex chromosome disorders and is characterized by short stature and gonadal dysgenesis. A few patients with TS achieve normal sexual development, menarche, and even pregnancy. We encountered two cases of Turner syndrome with spontaneous sexual development and menstruation. Read More

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http://dx.doi.org/10.1016/j.jpag.2020.04.002DOI Listing

Acute Myocardial Infarction After Tranexamic Acid: Review of Published Case Reports.

Chin Med Sci J 2020 Mar;35(1):65-70

Department of Anesthesiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China.

Objective To summarize cases of acute myocardial infarction (AMI) after tranexamic acid (TXA) administration. Methods Electronic databases were searched to identify all case reports presenting AMI after use of TXA. Two authors independently extracted data of patients' manifestation, examinations, medical history, treatment and outcome. Read More

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http://dx.doi.org/10.24920/003596DOI Listing

Adverse drug reactions in older adults: a retrospective comparative analysis of spontaneous reports to the German Federal Institute for Drugs and Medical Devices.

BMC Pharmacol Toxicol 2020 Mar 23;21(1):25. Epub 2020 Mar 23.

Research Division, Federal Institute for Drugs and Medical Devices (BfArM), Bonn, North Rhine-Westphalia, Germany.

Background: Older adults are more prone to develop adverse drug reactions (ADRs) since they exhibit numerous risk factors. The first aim was to analyse the number of spontaneous ADR reports regarding older adults (> 65) in the ADR database of the German Federal Institute for Drugs and Medical Devices (BfArM) and to set them in relation to i) the number of ADR reports concerning younger adults (19-65), and ii) the number of inhabitants and assumed drug-exposed inhabitants. The second aim was to analyse, if reported characteristics occurred more often in older vs. Read More

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http://dx.doi.org/10.1186/s40360-020-0392-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092423PMC

Coexistence of Conventional Leiomyoma, Fumarate Hydratase-deficient Atypical Leiomyoma, and Perivascular Epithelioid Cell Tumor in a Uterus: A Case Study.

Int J Gynecol Pathol 2020 Apr 6. Epub 2020 Apr 6.

Departments of Pathology (Y.L., R.V., C.-F.H., T.-C.W., B.M.R., D.X.) Gynecology and Obstetrics (R.V., C.-F.H., T.-C.W., B.M.R, D.X.) Oncology (C.-F.H., T.-C.W., D.X.), The Johns Hopkins Medical Institutions, Baltimore, Maryland Department of Gynecology and Obstetrics, The Third Affiliated Hospital of Zhengzhou University, Henan, China (Y.L.) Department of Pathology, Clara Maass Medical Center, Belleville E.M.B.D. Woodland Park OBGYN, LLC, Woodland Park (S.O.), New Jersey.

A 44-yr-old woman with menorrhagia and uterine fibroids underwent total laparoscopic hysterectomy, revealing several submucosal, intramural, and subserosal tan-white nodules in the uterus. Microscopic examination revealed tumors displaying 3 distinct morphologies: 1 tumor with features of conventional leiomyoma; 1 tumor with increased cellularity, staghorn/hemangiopericytoma-like vasculature, and occasional atypical cells with prominent red nucleoli and some perinucleolar halos suggesting a fumarate hydratase (FH)-deficient atypical leiomyoma; and 1 tumor with an admixture of epithelioid and spindled cells with the former arranged around blood vessels suggesting a perivascular epithelioid cell tumor (PEComa). Immunohistochemical studies confirmed these diagnoses by demonstrating loss of FH expression in the atypical leiomyoma and diffuse expression of HMB45 and cathepsin K in the tumor with epithelioid features. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000676DOI Listing

Uterine Inversion Secondary to a Large Prolapsed Leiomyoma: Diagnostic and Management Challenges.

Cureus 2020 Mar 3;12(3):e7168. Epub 2020 Mar 3.

Gynaecological Oncology, Guy's and St Thomas' NHS Foundation Trust, London, GBR.

Uterine inversion is characterised by the collapse of the fundus into the uterine cavity. Non-puerperal uterine inversion is an extremely rare entity, with less than 200 reported cases thus far. In light of the non-specific presentation, its diagnosis is challenging. Read More

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http://dx.doi.org/10.7759/cureus.7168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117607PMC

Prevalence and knowledge of heavy menstrual bleeding among gynecology outpatients by scanning a WeChat QR Code.

PLoS One 2020 2;15(4):e0229123. Epub 2020 Apr 2.

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.

The aim of this study was to assess menstrual blood loss (MBL) and knowledge of heavy menstrual bleeding (HMB) among the gynecology outpatients at Peking University People's Hospital, by scanning a WeChat (a social media application software developed by Tencent) QR Code using a mobile phone or tablet. This survey was conducted among outpatients who were treated at the Gynecology Department of Peking University People's Hospital between September 2016 and November 2016. All participants filled up the questionnaires and scales through WeChat: general information questionnaire, Pictorial Blood Loss Assessment Chart (PBAC), Menorrhagia Multi-Attribute Quality-of-Life Scale (MMAS), and HMB knowledge questionnaire. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229123PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117654PMC
July 2020
3.234 Impact Factor

Women With Congenital Hypofibrinogenemia/Afibrinogenemia: From Birth to Death.

Clin Appl Thromb Hemost 2020 Jan-Dec;26:1076029620912819

Nursing Department, Baoji Maternal and Child Health Hospital, Baoji, China.

Congenital fibrinogen disorders are a group of most frequent rare coagulation disorder, characterized by deficiency and/or defects in the fibrinogen molecule. Quantitative disorders include hypofibrinogenemia and afibrinogenemia. Due to their specific physiological characteristics, female patients tend to have congenital hypofibrinogenemia/afibrinogenemia, such as spontaneous recurrent abortion, menorrhagia, infertility, antepartum and postpartum hemorrhage, and so on. Read More

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http://dx.doi.org/10.1177/1076029620912819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288827PMC

A comparison of reproductive outcomes of patients with adenomyosis and infertility treated with High-Intensity focused ultrasound and laparoscopic excision.

Int J Hyperthermia 2020 ;37(1):301-307

Department of Gynecology, Third Xiangya Hospital of Central South University, Changsha, China.

The aim of this study was to compare the treatment effects of high-intensity focused ultrasound (HIFU) and laparoscopic excision (LE) in patients with adenomyosis and infertility. A total of 93 patients with adenomyosis and infertility who were treated with HIFU (50 patients) or LE (43 patients) from January 2012 to January 2017 at the Third Xiangya Hospital of Central South University were retrospectively analyzed. Clinical characteristics including dysmenorrhea severity pain score, menorrhagia severity scores, reproductive outcomes, complications during pregnancy and delivery, adverse effects, surgical complications, and other clinical variables were compared between the HIFU and LE groups. Read More

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http://dx.doi.org/10.1080/02656736.2020.1742390DOI Listing
January 2020

Comparison of Misoprostol and Mefenamic Acid on Reducing Menstrual Bleeding in Patients Suffering From Heavy Menstrual Bleeding.

J Family Reprod Health 2019 Sep;13(3):141-145

Fetal and Neonatal Research Center, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Heavy menstrual bleeding is one of the most frequent complaints of women. Various therapeutic approaches have been applied to treat this condition. In this study, we compared the efficacy of mefenamic acid and misoprostol in reducing menorrhagia. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072028PMC
September 2019

Central retinal vein occlusion secondary to severe iron-deficiency anaemia resulting from a plant-based diet and menorrhagia: a case presentation.

BMC Ophthalmol 2020 Mar 19;20(1):112. Epub 2020 Mar 19.

Ophthalmology Department, Gold Coast University Hospital, 1 Hospital Boulevard, Southport, Queensland, 4215, Australia.

In this case presentation, we present a young vegan patient who developed a CRVO secondary to severe iron-deficiency anaemia (IDA) attributable to menstrual losses and limited iron intake. CRVO is a rare complication of IDA.With rising calls for sustainable diets and rising evidence for a plant-based diet, there has been a rise in popularity of such diet forms. Read More

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http://dx.doi.org/10.1186/s12886-020-01372-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081704PMC

A Prospective Intervention Trial on Tailored Radiofrequency Ablation of Uterine Myomas.

Medicina (Kaunas) 2020 Mar 12;56(3). Epub 2020 Mar 12.

Division of Gynaecology, International Evangelical Hospital, 16122 Genoa, Italy.

Investigating the use of radiofrequency myolysis (RFM) for the treatment of fibroids through less invasive access by combining transvaginal ultrasound, hysteroscopy and laparoscopy. Fifty-four premenopausal women with 106 symptomatic uterine myomas. Patients underwent RFM in three ways: Vaginal Ultrasound-guided RFM (VU-RFM), Laparoscopic RFM (L-RFM) and Hysteroscopic-RFM (H-RFM). Read More

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http://dx.doi.org/10.3390/medicina56030122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143923PMC

Contained Morcellation of Very Large Uterus.

J Obstet Gynaecol Can 2020 Jun 11;42(6):802. Epub 2020 Mar 11.

Department of Obstetrics and Gynaecology, Centre Hospitalier Universitaire de Québec, Université Laval, Québec, QC. Electronic address:

A 38-year-old woman was referred to our centre for symptomatic leiomyoma. The patient had a large uterus, heavy menstrual bleeding, and compressive symptoms refractory to medical treatments. The patient was then scheduled for total laparoscopic hysterectomy with contained morcellation. Read More

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http://dx.doi.org/10.1016/j.jogc.2019.11.005DOI Listing

Coexistent Dedifferentiated Endometrioid Carcinoma of the Uterus and Adenocarcinoma of the Bladder in Lynch Syndrome: Case Report and Review of the Literature.

Appl Immunohistochem Mol Morphol 2020 Mar;28(3):e26-e30

Obstetrics and Gynecology, University of Illinois Hospital & Health Sciences System.

Lynch syndrome is an autosomal dominant disorder, caused by an abnormality in DNA mismatch repair genes and characterized by the development of a variety of cancers. Upper urinary tract urothelial carcinoma is well characterized in Lynch syndrome; however, support for the inclusion of bladder urothelial carcinoma is limited, except for MSH2 mutation carriers. Urologic adenocarcinoma has not been documented in Lynch syndrome. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000553DOI Listing

Successful surgical treatment of cardiac metastasis from uterine leiomyosarcoma: A case report and literature review.

J Obstet Gynaecol Res 2020 May 12;46(5):795-800. Epub 2020 Mar 12.

Department of Obstetrics and Gynecology, Nihon University School of Medicine, 30-1 Oyaguchi Kami-cho, Itabashi-ku, Tokyo, Japan.

Uterine leiomyosarcoma is a malignant soft tissue tumor resembling uterine fibroma clinically and is difficult to diagnose preoperatively. Since metastatic cardiac tumors are very rare and asymptomatic, most cardiac metastases are detected at autopsy after death due to other diseases. A 49-year-old woman presented with menorrhagia and anemia, and a uterine tumor. Read More

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http://dx.doi.org/10.1111/jog.14231DOI Listing

Ulipristal Acetate Efficacy in a Patient with Symptomatic Fibroid and Concomitant Pulmonary Embolism.

Case Rep Med 2020 22;2020:3249268. Epub 2020 Feb 22.

Department of Radiology, ASST Bergamo Est, Seriate, Italy.

Ulipristal acetate (UPA) is an effective drug for the treatment of symptomatic uterine fibroids. The drug is highly effective in controlling bleeding control and in the recovery of anemia. Here, we report the case of a woman with severe menorrhagia due to a uterine fibroid and with concomitant pulmonary embolism, a serious life-threatening condition. Read More

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http://dx.doi.org/10.1155/2020/3249268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057005PMC
February 2020

Menstrual Cycle Characteristics and Premenstrual Syndrome Prevalence Based on the Daily Record of Severity of Problems in Korean Young Adult Women.

J Korean Acad Nurs 2020 Feb;50(1):147-157

College of Nursing, Korea University, Seoul, Korea.

Purpose: This descriptive study aimed to identify the menstrual cycle characteristics and premenstrual syndrome (PMS) prevalence in Korean young adult women using the retrospective and prospective Daily Record of Severity of Problems (DRSP).

Methods: In the first stage, participants included 151 nursing students studying in a university located in Seoul. Data were collected from April 20 to June 2, 2017, using the questionnaire on menstrual characteristics, pictorial blood assessment chart, and retrospective DRSP. Read More

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http://dx.doi.org/10.4040/jkan.2020.50.1.147DOI Listing
February 2020

Congenital factor XI deficiency caused by a novel F11 missense variant: a case report.

Croat Med J 2020 Feb;61(1):62-65

Kristina Gotovac Jerčić, Department of Neurology, University Clinical Hospital Zagreb, Kišpatićeva 12, 10 000 Zagreb, Croatia,

Hereditary factor XI (FXI) deficiency is a mild bleeding disorder, rare in the general population but relatively common among Ashkenazi Jews. The human F11 gene comprises 15 exons, spanning over 23 kb of the long arm of chromosome 4 (4q35). Homozygotes or compound heterozygotes typically show severe FXI deficiency, whereas heterozygotes show partial or mild deficiency. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063557PMC
February 2020

Uterine tumor resembling ovarian sex cord tumor: A series of six cases displaying varied histopathological patterns and clinical profiles.

Indian J Pathol Microbiol 2020 Feb;63(Supplement):S81-S86

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Uterine tumors resembling ovarian sex cord tumor (UTROSCT) are a unique group of neoplasms with diverse morphology and immunophenotypic characteristics, coexpressing sex cord, epithelial, and smooth-muscle markers. To date, less than 100 cases have been reported and there is paucity of data concerning their clinical behavior.

Materials And Methods: All cases of uterine body tumors diagnosed over a period of two and a half years (2016-2018) were retrieved. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_340_19DOI Listing
February 2020

Bleeding in patients with sickle cell disease: a population-based study.

Blood Adv 2020 Mar;4(5):793-802

Center for Oncology Hematology Outcomes Research and Training, Division of Hematology Oncology, University of California, Davis School of Medicine, Davis, CA; and.

Bleeding is a known complication of sickle cell disease (SCD) and includes hemorrhagic stroke, hematuria, and vitreous hemorrhage. However, the incidence of bleeding events in patients with SCD has not been well described. We present a retrospective, population-based study examining the cumulative incidence of bleeding in 6423 patients with SCD from 1991 to 2014. Read More

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http://dx.doi.org/10.1182/bloodadvances.2019000940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065478PMC

Assessment of non-gynecological symptoms before and after removal of the Essure® sterilization device: a 6-month follow-up study.

Minerva Ginecol 2019 Dec;71(6):404-411

Department of Gynecology, Obstetrics and Reproductive Medicine, University Hospital of Brest, Brest, France.

Background: Most of the clinical adverse events associated with the Essure® sterilization device have been attributed to incidents during and immediately after device placement (perforation, infection, expulsion). The aim of this study was to prospectively evaluate the prevalence and severity of non-gynecological clinical symptoms (e.g. Read More

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http://dx.doi.org/10.23736/S0026-4784.19.04391-0DOI Listing
December 2019

Alleviation of Symptoms and Improvement of Endometrial Receptivity Following Laparoscopic Adenomyoma Excision and Secondary Therapy with the Levonorgestrel-releasing Intrauterine System.

Reprod Sci 2020 Jun 6;27(6):1259-1265. Epub 2020 Jan 6.

Department of Obstetrics and Gynecology, Fujian Provincial Hospital, Clinical Medical School of Fujian Medical University, 134 East Road, Fuzhou, 350001, Fujian, People's Republic of China.

To assess the treatment efficacy of adenomyoma and improvement in implantation receptivity associated with the levonorgestrel-releasing intrauterine system (LNG-IUS) combined with adenomyoma resection. Fifty subjects (control group) underwent laparoscopic adenomyoma excision and received gonadotropin-releasing hormone (GnRH) agonists, and 201 subjects (experimental group) underwent laparoscopic adenomyoma resection and received GnRH agonists combined with the LNG-IUS. Pipelle endometrial biopsies were obtained in the mid-luteal phase, before the operation, and 19 months after the operation. Read More

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http://dx.doi.org/10.1007/s43032-019-00130-4DOI Listing

Primary Umbilical Endometriosis in an Adolescent Girl: Unsuspected Pathology.

European J Pediatr Surg Rep 2020 Jan 8;8(1):e10-e13. Epub 2020 Feb 8.

Department of Paediatric Surgery, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom of Great Britain and Northern Ireland.

Endometriosis affects 7 to 10% of women of reproductive age. Primary umbilical endometriosis (PUE) is even rarer with unclear pathogenesis. We report a case of PUE possibly the youngest patient reported in the literature. Read More

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http://dx.doi.org/10.1055/s-0039-1700987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007811PMC
January 2020

Bernard-Soulier syndrome or idiopathic thrombocytopenic purpura: A case series.

Authors:
Nahid Reisi

Caspian J Intern Med 2020 ;11(1):105-109

Department of Pediatric Hematology and Oncology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Bernard-Soulier syndrome (BSS) is a rare, autosomal recessive platelet function disorder which is commonly mistaken for idiopathic thrombocytopenic purpura (ITP).The report includes seven cases of BSS that have been diagnosed and treated as ITP for a long time.

Methods: Between 2006 and 2016, data of seven BSS patients who have long been diagnosed and treated as ITP were collected and analyzed. Read More

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http://dx.doi.org/10.22088/cjim.11.1.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992729PMC
January 2020

Indian Sarsaparilla (Hemidesmus indicus): Recent progress in research on ethnobotany, phytochemistry and pharmacology.

J Ethnopharmacol 2020 May 30;254:112609. Epub 2020 Jan 30.

Department of Life Sciences, Presidency University, Kolkata, India. Electronic address:

Ethnopharmacological Relevance: Hemidesmus indicus (L.) R. Br. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112609DOI Listing