Biochem Biophys Res Commun 2020 05 11;525(4):915-920. Epub 2020 Mar 11.
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Ji-nan, 25000, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Ji-nan, 25000, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Medicine, Ji-nan, 25000, China; School of Medicine, Shandong University, Ji-nan, 25000, China; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University & Shandong Academy of Medical Sciences, Ji-nan, 25000, China. Electronic address:
Affective disorders are a set of mental disorders and particularly disrupt the mental health of susceptible women during puberty, pregnancy, parturition and menopause transition, which are characterized by dramatic changes in reproductive hormone profiles. The serum FSH level changes significantly during these periods; yet, the role of FSH in mood regulation is poorly understood. In the current study, FSHR knockout (Fshr) mice displayed enhanced affective disorder behaviors in an open field test and a forced swim test, accompanied by altered gene expression profiles. Read More