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Semin Neurol 2018 Dec 6;38(6):627-633. Epub 2018 Dec 6.

Department of Neurology, University at Buffalo School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York.

Headache is a neurologic disorder that displays gender dichotomy. It is well established that there is a strong link between migraine headache and sex hormones, specifically estrogen, which influences the severity of migraines during the menstrual cycle, pregnancy, and menopause. Furthermore, the epidemiology of headaches during pregnancy and the postpartum period is very distinct from that in males or nonpregnant females, in part due to the hemodynamic and hematologic changes that occur during pregnancy. Read More

PLoS One 2018 6;13(12):e0208485. Epub 2018 Dec 6.

Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Iron deficiency anemia (IDA) is a common micronutrient deficiency worldwide, and an important health problem especially in women of reproductive age. This study aimed to determine the relationship between IDA and sexual satisfaction and function among reproductive-aged Iranian women. In this study, 129 women (52 with IDA and 77 non-IDA) with age 18-45 in Mahshahr, Iran were recruited. Read More

MMWR Morb Mortal Wkly Rep 2018 Dec 7;67(48):1333-1338. Epub 2018 Dec 7.

Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, CDC.

Uterine cancer is one of the few cancers with increasing incidence and mortality in the United States, reflecting, in part, increases in the prevalence of overweight and obesity since the 1980s (1). It is the fourth most common cancer diagnosed and the seventh most common cause of cancer death among U.S. Read More

Acta Med Port 2018 Nov 30;31(11):680-690. Epub 2018 Nov 30.

Unidade de Saúde Familiar S. Julião. Agrupamento de Centros de Saúde de Lisboa Ocidental e Oeiras. Lisboa. Portugal.

Introduction: Female sexual dysfunction is a common problem, affecting more than 1/3 of women during their lives. The aim of this review is to review the evidence for the effectiveness of testosterone in sexual dysfunction in postmenopausal women, particularly in the improvement of sexual desire.

Material And Methods: The authors searched in international databases National Guidelines Clearinghouse, Guidelines Finder, Cochrane Library and MEDLINE/PubMed, for guidelines, systematic reviews, meta-analysis and randomized controlled trials, published between January 2005 and February 2017, using the MeSH terms 'testosterone', 'androgens', 'libido', 'sexual dysfunctions' and 'menopause'. Read More

Arch Gynecol Obstet 2018 Dec 5. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Shuaifuyuan No 1, Dongcheng District, Beijing, China.

Objective: To investigate the incidence and predictors of gynecologic malignancies among postmenopausal patients with endometrial fluid collection (EFC).

Methods: All patients with EFC diagnosed by transvaginal sonography (TVS) were retrospectively reviewed if they had undergone biopsy of the endometrium from January 2008 to January 2016 in a tertiary teaching hospital. Follow-up ended in June 2017. Read More

J Womens Health (Larchmt) 2018 Dec 1. Epub 2018 Dec 1.

5 Premier Applied Sciences, Premier, Inc., Charlotte, North Carolina.

Objective: Reproductive events have been linked with increased cardiovascular risk in women, but whether they are associated with pre-clinical peripheral arterial disease (PAD) has been understudied. We evaluated associations between reproductive factors and later-life ankle-brachial index (ABI), femoral artery intima-media thickness (fIMT), and femoral plaques.

Methods: Cross-sectional analysis of 707 multiethnic women who participated in a follow-up exam of the San Diego Population Study in 2007-2011. Read More

Hum Reprod Update 2018 Dec 1. Epub 2018 Dec 1.

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Background: The effect of postmenopausal hormone therapy (HT) on cardiovascular disease (CVD) risk remains controversial.

Objective And Rationale: We aimed to systematically review the evidence regarding the role of dose, route of hormone administration, timing of initiation and duration of HT on cardiovascular risk among postmenopausal women.

Search Methods: The electronic databases Medline Ovid, Web of Science and Cochrane Central were systematically searched to identify studies published before 30 January 2018. Read More

Integr Med Res 2018 Dec 25;7(4):303-306. Epub 2018 Oct 25.

Department of Korean Medicine Obstetrics & Gynecology, College of Korean Medicine, Dae-jeon University, Daejeon, Republic of Korea.

Uterine myoma is a common benign tumor. When the symptoms are not severe, patients are often suggested to wait for menopause without treatment. If the size becomes too large or the symptoms get worse, the patient will receive surgery or hormone therapy. Read More

Neuroendocrinology 2018 Nov 30. Epub 2018 Nov 30.

Menopause is associated with significant symptomatic burden, with approximately two thirds of post menopausal women suffering from vasomotor symptoms, hot flushes and night sweats. The mainstay of treatment for hot flushes continues to be hormone replacement therapy. However, as HRT is contraindicated in some cases, alternative, efficacious treatment options are also required. Read More

Anticancer Res 2018 Dec;38(12):6615-6620

London Breast Institute, London, U.K.

Background/aim: Hypoactive sexual desire disorder (HSDD) is hypothesised to manifest in postmenopausal women at onset of menopause due to decreased oestrogen levels. Transdermal testosterone is a potential treatment option. This systematic review explores the relationship between the incidence of breast cancer and transdermal testosterone use. Read More

J Minim Invasive Gynecol 2018 Nov 29. Epub 2018 Nov 29.

Department of Obstetrics and Gynecology of Macedonio Melloni Hospital, University of Milan, Milan, Italy.

Maturitas 2019 Jan 12;119:46-53. Epub 2018 Nov 12.

Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Cardiovascular disease is the leading cause of death in women throughout the United States and Europe. Despite efforts to raise awareness, the sex-specific risk factors are still poorly recognized in both regions, and many women do not identify cardiovascular disease as a primary threat. During midlife, the incidence of cardiovascular disease increases dramatically, and this unique time gives an opportunity to identify both traditional cardiovascular risk factors as well as emerging risk factors unique to women. Read More

Maturitas 2019 Jan 23;119:1-7. Epub 2018 Oct 23.

Department of Pathobiology, University of Illinois College of Veterinary Medicine, 2001 S. Lincoln Ave, Urbana, IL, USA. Electronic address:

Objective: Hot flashes are believed to be related to hormonal changes. However, the relationship between hormonal fluctuations and hot flashes has not been studied. The objective of this study is to determine hormone measurement summaries that best explain the incidence of hot flashes in midlife women. Read More

Menopause 2018 Dec 3. Epub 2018 Dec 3.

Department of Nephrology, General Hospital of Chinese People's Liberation Army, Beijing, China.

Objectives: Changes in serum protein levels of fibroblast growth factor 23 (FGF23) and Klotho resulting from bone metabolism are still controversial. The purpose of this study was to observe the relationship between FGF23 and Klotho serum proteins and lumbar spine bone mineral density (LBMD) in northern Chinese postmenopausal women.

Methods: This was a community-based cross-sectional study carried out in Shenyang, a northern Chinese city. Read More

Menopause 2018 Dec 3. Epub 2018 Dec 3.

University of Illinois at Chicago, Chicago, IL.

Menopause 2018 Dec 3. Epub 2018 Dec 3.

TherapeuticsMD, Boca Raton, FL.

Objective: The aim of this study was to determine the clinical meaningfulness of TX-001HR in reducing moderate to severe vasomotor symptoms (VMS) in menopausal women with a uterus.

Methods: In the REPLENISH study (NCT01942668), women with moderate to severe hot flushes (≥7/d or ≥50/wk) were enrolled in a VMS substudy and randomized to four doses of daily TX-001HR (17β-estradiol/progesterone) or placebo. Participants assessed improvement of their VMS by the Clinical Global Impression and the Menopause-Specific Quality of Life (MENQOL) questionnaire, which were used to define clinical responders, clinically important differences (CIDs) or minimal CID (MCID) in VMS frequency. Read More

Menopause 2018 Dec 3. Epub 2018 Dec 3.

Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China.

Objective: To assess the effect of early life exposure to famine, as endured during 1959 to 1961 in China, on reproductive aging in adult women.

Methods: Between 2011 and 2012, 2,868 women born around the Chinese famine period (1956-1964) were enrolled in this study from three communities in China. Age at natural menopause was obtained retrospectively from a structured questionnaire. Read More

Curr Opin Neurol 2018 Nov 30. Epub 2018 Nov 30.

Medicina Vascolare e D'Urgenza-Stroke Unit, Ospedale Santa Maria della Misericordia, Università di Perugia, Perugia, Italy.

Purpose Of Review: The absolute risk of pregnancy-associated intracranial haemorrhage (ICH) has been reported to be relatively low and often associated with high risks of life-long disabilities and mortality. The aim of this narrative review was obtaining a better understanding of the current management practices for ICH, unruptured aneurysms and/or arteriovenous malformations during pregnancy, as well as the effects of future pregnancies, and the uses of oral contraceptive or HRT.

Recent Finding: General guidelines for the management of ICH are used for pregnant women but additional expedient and thorough evaluation of foetal viability and its gestational age are requested. Read More

Obes Rev 2018 Dec;19 Suppl 1:73-83

Human Nutrition Unit, School of Biological Sciences, University of Auckland, Auckland, New Zealand.

With current 'one-size-fits-all' obesity prevention and management strategies proving largely ineffective, the focus has shifted towards a more tailored, individualized approach. However, investigation of the mechanisms underlying inter-individual variability in metabolic profile and response to intervention often yield conflicting results. Indeed, it is perhaps surprising that despite at least a century of recognition that sex hormones influence metabolism, firm conclusions regarding the effects of the menstrual cycle, hormonal contraception and menopause on many aspects of energy expenditure and substrate utilization remain to be drawn. Read More

Breast Cancer Res 2018 Dec 3;20(1):147. Epub 2018 Dec 3.

Nutritional Methodology and Biostatistics Group, Nutrition and Metabolism Section, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon Cedex 08, France.

Background: Few published breast cancer (BC) risk prediction models consider the heterogeneity of predictor variables between estrogen-receptor positive (ER+) and negative (ER-) tumors. Using data from two large cohorts, we examined whether modeling this heterogeneity could improve prediction.

Methods: We built two models, for ER+ (Model) and ER- tumors (Model), respectively, in 281,330 women (51% postmenopausal at recruitment) from the European Prospective Investigation into Cancer and Nutrition cohort. Read More

Exp Biol Med (Maywood) 2018 Dec 3:1535370218816653. Epub 2018 Dec 3.

1 Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Impact Statement: Sex-differences in the incidence and severity of inflammatory lung diseases have been recognized for years. Women of reproductive age are more likely to suffer from chronic lung disease, with higher mortality rates than men. Physiological changes in hormone levels such as those occurring during the menstrual cycle, pregnancy, and menopause have been associated with lung function changes and asthma symptoms. Read More

Exp Biol Med (Maywood) 2018 Dec 3:1535370218817503. Epub 2018 Dec 3.

1 Unidade de Biotecnologia, Universidade de Ribeirão Preto - UNAERP, Ribeirão Preto, SP 14096-900, Brazil.

Impact Statement: The results of this work provide preliminary evidence that ovariectomized rats display the vaginal smear cells typical of the estrous phase of mature rats after long-term ingestion of Colocasia esculenta flavonoid glycosides. Moreover, the treatment caused beneficial effects on endocrine and reproductive organs compared to estradiol. The animals did not exhibit significant body weight alterations among the groups, demonstrating the maintenance of standard metabolism and energy balance. Read More

Pol J Pathol 2018 ;69(3):321-324

Endosalpingiosis is a benign condition characterized by the presence of tubal epithelium outside the fallopian tube and the absence of endometrial stroma. Florid cystic endosalpingiosis is a very rare form of endosalpingiosis that presents as a tumor-like lesion. We report the case of a 67-year-old woman who presented with a cystic lesion of the uterus. Read More

Neurochem Int 2018 Nov 27. Epub 2018 Nov 27.

Department of Neurological Surgery and The Miami Project to Cure Paralysis, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, 33136, USA. Electronic address:

A woman's risk for stroke increases exponentially following the onset of menopause; however, the underlying mechanisms responsible for the increased risk remain unknown. The depletion of endogenous estrogen at menopause is known to activate the inflammatory response. Therefore, in this study we have used reproductively senescent (RS) rats to test the hypotheses that (1) inflammasome activation is significantly higher in the brain of RS females (RSF) as compared to their younger counterparts and age-matched senescent male rats, and that (2) RS triggers an innate immune response mediated in part by inflammasome-containing extracellular vesicles (EV) that originate in the female reproductive organs and then spreads to the brain. Read More

Climacteric 2018 Nov 30:1-6. Epub 2018 Nov 30.

a Department of Gynecology and Obstetrics , Peking University People's Hospital , Beijing , P. R. China.

Objective: The study aimed to identify the factors associated with the sexual lives of perimenopausal and postmenopausal women in China.

Methods: A total of 426 participants were approached about this study from May 2012 to August 2013. In total, 252 cases were included in this study. Read More

J Electrocardiol 2018 Nov - Dec;51(6):1085-1089. Epub 2018 Sep 24.

Faculty of Medicine, Slovak Medical University, Bratislava, Slovak Republic.

Both obesity and menopause are significant cardiovascular risk factors. In postmenopausal women the protective effect of estrogens is reduced and menopause is frequently associated with occurrence of other significant cardiovascular factors including obesity. This study was focused on evaluating the effect of obesity on the QRS complex in pre- and postmenopausal women. Read More

Neurobiol Aging 2018 Oct 5;74:213-224. Epub 2018 Oct 5.

Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA; Clinical Pharmacy and Pharmaceutical Economics and Policy, School of Pharmacy, University of Southern California, Los Angeles, CA, USA; Center for Innovation in Brain Science, College of Medicine Tucson, University of Arizona, Tucson, AZ, USA. Electronic address:

Perimenopause marks initiation of female reproductive senescence. Age of onset is only 47% heritable suggesting that additional factors other than inheritance regulate this endocrine aging transition. To elucidate these factors, we characterized transcriptional and epigenomic changes across endocrine aging using a rat model that recapitulates characteristics of the human perimenopause. Read More

Menopause 2018 Dec;25(12):1403-1417

Department of Endocrinology, Creighton University, Omaha, NE.

In 1970, there were no drugs under study for osteoporosis. Estrogen was used, but little was known about the correct dose for preventing bone loss. At that time, fractures were not even recognized as a disease, but regarded as part of normal aging. Read More

Menopause 2018 Dec;25(12):1395-1400

Oriel College, University of Oxford, Oxford, United Kingdom University of Glasgow, Glasgow, United Kingdom.

Menopause 2018 Nov 26. Epub 2018 Nov 26.

Department of Kinesiology, University of Massachusetts Amherst, Amherst, MA.

Objective: The aim of the study was to evaluate if there are differences in endothelial function before and after acute exercise in women at different menopausal stages with high and low cardiorespiratory fitness.

Methods: Participants were healthy high-fit premenopausal (n = 11), perimenopausal (n = 12), and postmenopausal women (n = 13) and low-fit perimenopausal (n = 7) and postmenopausal women (n = 8). Brachial artery flow-mediated dilation (FMD) was measured before and after acute moderate intensity exercise. Read More

Menopause 2018 Nov 26. Epub 2018 Nov 26.

TherapeuticsMD, Boca Raton, FL.

Objective: The aim of the study was to describe the effects of TX-001HR (17β-estradiol [E2] and natural progesterone [P4] in a single oral capsule) on menopause-specific quality of life in women with moderate to severe vasomotor symptoms (VMS).

Methods: The REPLENISH study (NCT01942668) was a phase 3, randomized, double-blind, placebo-controlled, multicenter trial which evaluated four E2/P4 doses in postmenopausal women with VMS and a uterus. Women with moderate to severe hot flushes (≥7/d or ≥50/wk) were included in a VMS substudy. Read More

Clin Endocrinol (Oxf) 2018 Nov 29. Epub 2018 Nov 29.

Department of Investigative Medicine, Hammersmith Hospital, Imperial College London, London, UK.

The clinical sequelae of oestrogen deficiency during menopause are undoubted. However, the pathophysiological role of testosterone during the menopause is less clear. Several randomised, placebo-controlled clinical trials suggest that testosterone therapy improves sexual function in post-menopausal women. Read More

Clin Calcium 2018 ;28(12):1575-1580

Toranomon Hospital Endocrine Center, Tokyo, Japan.

Osteoporosis is deterioration of bone integrity caused by bone loss(bone mineral density decrease)due to failure of coupling of bone resorption and bone formation. Various pathophysiological conditions other than natural menopause or aging are involved in the development of osteoporosis. When there is a specific cause of the disease, it is referred to as secondary osteoporosis. Read More

Diabetes 2018 Nov 28. Epub 2018 Nov 28.

Department of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, TX 77843, United States

Premenopausal women exhibit enhanced insulin sensitivity and reduced incidence of type 2 diabetes mellitus (T2D) compared with age-matched men, but this advantage disappears after menopause with disrupted glucose homeostasis, in part owing to a reduction in circulating 17β-estradiol (E). Fasting hyperglycemia is a hallmark of T2D derived largely from dysregulation of hepatic glucose production (HGP), in which Foxo1 plays a central role in the regulation of gluconeogenesis. Here, we investigated the action of E on glucose homeostasis in male and ovariectomized (OVX) female control and liver-specific Foxo1 knockout (L-F1KO) mice, and sought to understand the mechanism by which E regulates gluconeogenesis via an interaction with hepatic Foxo1. Read More

Asian Pac J Cancer Prev 2018 Nov 29;19(11):3167-3174. Epub 2018 Nov 29.

Doctor of Public Health Program, Faculty of Public Health, Khon Kaen University, Thailand. Email:

Background and Purpose: This study focused on molecular subtypes and prognostic factors for survival of preand post-menopausal breast cancer patients. Methods: A retrospective cohort study was performed on 523 patients with invasive carcinoma of the breast treated at Ubon Ratchathani Cancer Hospital,Thailand from 2002 to 2016. Patient characteristics were collected based on a systematic chart audit from medical records. Read More

J Womens Health (Larchmt) 2018 Nov 28. Epub 2018 Nov 28.

3 Division of Women's Health Internal Medicine, Mayo Clinic , Scottsdale, Arizona.

The risks and benefits of menopausal hormonal therapy (HT) have been evaluated extensively over the past three decades. While the efficacy of HT for management of menopausal symptoms, including vasomotor symptoms and vaginal dryness is well established, its relationship to cardiovascular outcomes is complex. The timing hypothesis, which posits that the cardiovascular effects of HT depend on the timing of initiation of HT in relation to menopause, has helped shape our understanding of the cardiovascular outcomes related to HT. Read More

J Womens Health (Larchmt) 2018 Nov 28. Epub 2018 Nov 28.

4 Department of Obstetrics and Gynecology, New York University School of Medicine , New York, New York.

Background: The Surveillance, Epidemiology, and End Result (SEER) database shows a variable increase in endometrial cancer incidence over time. The objective of this review was to examine published endometrial cancer rates and potential etiologies.

Methods: Endometrial cancer incidence was obtained from the SEER Program database from 1975 through 2014, and a test for trend in incidence was calculated. Read More

Physiol Res 2018 Nov;67(Supplementum 3):S455-S464

Department of Steroids and Proteofactors, Institute of Endocrinology, Prague, Czech Republic.

After menopause, when estrogen levels decrease, there is room for the activity of anthropogenic substances with estrogenic properties - endocrine disruptors (EDs) - that can interfere with bone remodeling and changes in calcium-phosphate metabolism. Selected unconjugated EDs of the bisphenol group - BPA, BPS, BPF, BPAF, and the paraben family - methyl-, ethyl-, propyl-, butyl-, and benzyl-parabens - were measured by high performance liquid chromatography-tandem mass spectrometry in the plasma of 24 postmenopausal women. Parameters of calcium-phosphate metabolism and bone mineral density were assessed. Read More

Oral Radiol 2018 Mar 5. Epub 2018 Mar 5.

Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029, Jiangsu, China.

Objectives: This study was performed to analyze the aging-related changes of the female condylar bone mineral density (BMD) and trabecular structure by cone-beam computed tomography (CBCT), and determine whether the condylar structure shows obvious changes after menopause.

Methods: The CBCT images of 160 female patients who met the inclusion criteria for the study were collected and divided into four groups by age (20-29 years, 30-39 years, premenopausal, and postmenopausal groups). Computer processing software CT-Analyser (Version 1. Read More

J Stroke Cerebrovasc Dis 2018 Nov 24. Epub 2018 Nov 24.

Center for Emotional and Behavioral Disorders, National Hospital Organization Hizen Psychiatric Center, Saga, Japan.

Background: Although several studies have reported an association between parity and increased risk of stroke, this relationship remains controversial.

Aims: The present study aimed to determine whether parity is associated with silent brain infarction (SBI), independent of other confounders.

Methods: We analyzed the brain magnetic resonance imaging findings in 576 of community-dwelling older adults with a mean age of 72. Read More

Neuroscience 2018 Dec;394:303-315

Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; California National Primate Research Center, Davis, CA 95616, United States; Department of Neurology, School of Medicine, University of California, Davis, CA 95616, United States. Electronic address:

Age- and menopause-related deficits in working memory can be partially restored with estradiol replacement in women and female nonhuman primates. Working memory is a cognitive function reliant on persistent firing of dorsolateral prefrontal cortex (dlPFC) neurons that requires the activation of GluN2B-containing glutamate NMDA receptors. We tested the hypothesis that the distribution of phospho-Tyr1472-GluN2B (pGluN2B), a predominant form of GluN2B seen at the synapse, is sensitive to aging or estradiol treatment and coupled to working memory performance. Read More

Sleep 2018 Nov 13. Epub 2018 Nov 13.

Thomas Roth Sleep Disorders & Research Center, Henry Ford Health System, Detroit, Michigan.

Study Objectives: Insomnia is a leading cause of disability in postmenopausal women. Multicomponent cognitive-behavioral therapy for insomnia (CBTI) is a first-line treatment for chronic insomnia, but support for its efficacy in treating menopause-related insomnia is scarce. The present study evaluated whether CBTI is an efficacious treatment for menopause-related chronic insomnia, and whether sleep restriction therapy (SRT)-a single component of CBTI-is equally effective compared to CBTI. Read More

Am J Epidemiol 2018 Nov 27. Epub 2018 Nov 27.

Unit of Molecular Epidemiology and Genetics in Infections and Cancer. Cancer Epidemiology Research Programme. Bellvitge Biomedical Research Institute (IDIBELL). Catalan Institute of Oncology.

The role of hormonal factors in lymphoid neoplasms etiology remains unclear. Previous studies have yielded conflicting results, been underpowered to assess many lymphoma subtypes, or lacked detailed information on relevant exposures. Within the European Prospective Investigation into Cancer and Nutrition cohort, we analyzed comprehensive data collected at baseline (1992-2000) on reproductive factors and exogenous hormone use among 343,458 women, including 1,427 incident B-cell non-Hodgkin lymphomas (NHL) and its major subtypes identified after a mean follow-up of 14 years (through 2015). Read More

PLoS Med 2018 Nov 27;15(11):e1002704. Epub 2018 Nov 27.

The University of Queensland, School of Public Health, Brisbane, Queensland, Australia.

Background: Cigarette smoking is associated with earlier menopause, but the impact of being a former smoker and any dose-response relationships on the degree of smoking and age at menopause have been less clear. If the toxic impact of cigarette smoking on ovarian function is irreversible, we hypothesized that even former smokers might experience earlier menopause, and variations in intensity, duration, cumulative dose, and age at start/quit of smoking might have varying impacts on the risk of experiencing earlier menopause.

Methods And Findings: A total of 207,231 and 27,580 postmenopausal women were included in the cross-sectional and prospective analyses, respectively. Read More

Clin Proteomics 2018 16;15:36. Epub 2018 Nov 16.

2Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Number 128, Shenyang Road, Shanghai, 200011 China.

Background: Natural menopause is always accompanied by specific signs and symptoms, suggesting physiological changes in this peoriod. However, no systematic study has assessed the changes at molecular level in the ovaries during the menopausal transition so far. This study integrated quantitative proteome and acetyl-proteome to comprehensively uncover the changes of ovarian protein and protein-acetylation profiles in this transitional period. Read More

J Sports Sci Med 2018 Dec 20;17(4):580-588. Epub 2018 Nov 20.

University of Szeged, Interdisciplinary Excellence Centre, Department of Physiology, Anatomy and Neuroscience.

Cardiovascular morbidity and mortality of premenopausal women are significantly lower compared to men of similar age. However, this protective effect evidently decreases after the onset of menopause. We hypothesized that physical exercise could be a potential therapeutic strategy to improve inflammatory processes and cardiovascular antioxidant homeostasis, which can be affected by the loss of estrogen and the adverse environmental factors, such as overnutrition. Read More

Climacteric 2018 Nov 27:1-14. Epub 2018 Nov 27.

a Department of Obstetrics and Gynecology , University of Bern , Bern , Switzerland.

In women, body weight increases with age. Often menopausal hormone therapy (MHT) is blamed for enhancing this effect. In recent years, the debate on bioidentical MHT including micronized progesterone (MP) has increased. Read More

Nat Prod Commun 2016 Nov;11(11):1733-1740

Isoflavones can exert their action on various levels: on cardiovascular system, bone and muscle health, on cancer, on menopausal symptoms, on obesity, on thyroid and on cognitive function. The aim of this systematic review is to evaluate the multidimensional effects of phytoestrogens in postmenopausal woman, and specifically to explore the impact on scientific literature. A research strategy was planned on PubMed and Scopus by defining the following key words:: menopause, climacteric, soy, isoflavone, phytoestrogens, cardiovascular system, bone mineral density, muscle mass, cancer, thyroid, obesity, cognitive. Read More