66,645 results match your criteria Menopause New York N.Y.[Journal]


Intravaginal treatment with Marantodes Pumilum (Kacip Fatimah) ameliorates vaginal atrophy in rats with post-menopausal condition.

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address:

Ethnopharmacological Relevance: Marantodes pumilum (MP) (Kacip Fatimah) is used to maintain the well-being of post-menopausal women. However, its role in ameliorating post menopause-related vaginal atrophy (VA) is unknown.

Aims: To investigate the ability of intravaginal MP gel treatment to ameliorate VA in sex-steroid deficient condition, mimicking post-menopause. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.027DOI Listing
February 2019

Unintended pregnancy: a framework for prevention and options for midlife women in the US.

Womens Midlife Health 2017 15;3. Epub 2017 Sep 15.

6UCSF School of Nursing, Research Faculty, Advancing New Standards in Reproductive Health Program (ANSIRH), UCSF Bixby Center for Global Reproductive Health, University of California, San Francisco, CA USA.

Recently unintended pregnancies have been described as "a new kind of mid-life crisis." Given the high prevalence of unwanted or mistimed pregnancy in the US, we examined the sexual and reproductive health patterns of sexually active midlife women. An examination of the prevalence of unintended pregnancy among midlife women revealed a gap in data indicating unmet sexual and reproductive health needs of midlife women. Read More

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http://dx.doi.org/10.1186/s40695-017-0027-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299952PMC
September 2017

Contraception for midlife women: lack of information? Lack of interest? Lack of investment?

Womens Midlife Health 2017 13;3. Epub 2017 Sep 13.

2Obstetrics, Gynecology and Reproductive Sciences, Robert Wood Johnson Medical School, Piscataway Township, NJ USA.

Despite the growing population of midlife women in the USA and in other economically-advantaged countries, there is scant research focusing on this population, especially regarding contraceptive choices in those at risk for unwanted or unplanned pregnancy. As women approach menopause, the increasing irregularity of their menstrual cycles and changing endocrine patterns present challenges for preventing unintended pregnancy, or, on the flip side, planning for a desired pregnancy. In this thematic series, we have brought together researchers and clinicians who address many of these tough clinical scenarios and offer suggestions not only for clinical management of optimal contraceptive choices for midlife women, but also suggestions for future research in this area. Read More

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http://dx.doi.org/10.1186/s40695-017-0025-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299937PMC
September 2017

Contraceptive preferences and unmet need for contraception in midlife women: where are the data?

Womens Midlife Health 2017 11;3. Epub 2017 Sep 11.

2Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, Washington USA.

This commentary discusses the limited availability of information on contraceptive preferences and unmet need for contraception among midlife women in both high and low income countries. Given that risk of pregnancy continues until women reach menopause and given the increased risk of pregnancy complications, elective abortion, and maternal mortality in women aged 45 to 54 years old, increased focus on gathering basic data on midlife women's preferences and unmet need is warranted. Read More

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http://dx.doi.org/10.1186/s40695-017-0026-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299985PMC
September 2017

Contraception and conception in Mid-life: a review of the current literature.

Womens Midlife Health 2017 16;3. Epub 2017 Aug 16.

University Hospitals MacDonald Women's Hospital, 11100 Euclid Avenue, Cleveland, OH 44106 USA.

In the United States, there are an increasing number of couples who are intentionally delaying child-bearing. As the average age of mothers continues to rise, more and more women are being faced with the difficulties of attempting conception at the various stages leading up to the menopausal transition. Not only do the chances of conception drastically decrease after the age of 40 years, but the probability of fetal loss (both early and late in pregnancy) significantly increases during this period as well. Read More

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http://dx.doi.org/10.1186/s40695-017-0022-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300028PMC

The Seattle Midlife Women's Health Study: a longitudinal prospective study of women during the menopausal transition and early postmenopause.

Womens Midlife Health 2016 9;2. Epub 2016 Nov 9.

2Department of Family and Child Nursing, University of Washington, Seattle, WA 98195, USA.

Background: The need for longitudinal, population-based studies to illuminate women's experiences of symptoms during the menopausal transition motivated the development of the Seattle Midlife Women's Health Study.

Methods: Longitudinal, population-based study of symptoms women experienced between the Late Reproductive stage of reproductive aging and the early postmenopause. Data collection began in 1990 with 508 women ages 35-55 and continued to 2013. Read More

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http://dx.doi.org/10.1186/s40695-016-0019-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299967PMC
November 2016

Cohort profile: Women's Healthy Ageing Project (WHAP) - a longitudinal prospective study of Australian women since 1990.

Womens Midlife Health 2016 4;2. Epub 2016 Oct 4.

1Department of Medicine-Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria 3050 Australia.

Background: The cohort was commenced to examine women's health from midlife (45-55 years) before the menopausal transition and into ageing.

Methods: Randomised selection and assessment of 2,001 women living in the Melbourne metropolitan area was conducted by the Roy Morgan Centre in 1990/91. Of the 779 women who met the entry criteria for the longitudinal follow-up (aged 45-55 years, menstruating, having a uterus and at least one ovary and not taking hormone therapy) 438 agreed to be seen annually across the menopausal transition from 1992 to 1999. Read More

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http://dx.doi.org/10.1186/s40695-016-0018-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300017PMC
October 2016

Methods in a longitudinal cohort study of late reproductive age women: the Penn Ovarian Aging Study (POAS).

Womens Midlife Health 2016 27;2. Epub 2016 Jan 27.

2Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, U.S, Philadelphia, USA.

Background: This report describes the methods utilized in the Penn Ovarian Aging Study (POAS), which is a longitudinal cohort study of hormone dynamics and menopausal symptoms of women in the menopause transition.

Methods/design: The cohort is a community-based sample of generally healthy women enrolled in the late reproductive years. The study population is a stratified random sample of African-American and Caucasian women, identified by random digit dialing. Read More

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http://dx.doi.org/10.1186/s40695-016-0014-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299955PMC
January 2016

The Passo Fundo Cohort Study: design of a population-based observational study of women in premenopause, menopausal transition, and postmenopause.

Womens Midlife Health 2015 18;1:12. Epub 2015 Dec 18.

3Gynecological Endocrinology Unit, Division of Endocrinology, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS Brazil.

Background: The Passo Fundo Cohort Study (PFS) is a population-based longitudinal observational study of pre-, peri-, and postmenopausal women that has been ongoing since 1995 in Passo Fundo, a city in southern Brazil. This paper describes the rationale and design of the PFS and summarizes objectives and procedures that have been updated during follow-up.

Methods/design: Women in the PFS have been followed for a variety of diseases that are frequent in menopause. Read More

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http://dx.doi.org/10.1186/s40695-015-0013-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298002PMC
December 2015

Confronting the challenges of the menopausal transition.

Womens Midlife Health 2015 5;1. Epub 2015 Oct 5.

Division of Reproductive Endocrinology and Infertility, Queen's University, Kingston, Ontario K7L 4 V1 Canada.

Canada's Generation X is now entering the menopausal transition and pursuing effective therapy for bothersome vasomotor symptoms. They do so at a time when confusion about the safe and appropriate use of menopausal hormone therapy (MHT) has never been greater. Misplaced fears among women and their health care providers about MHT have, in many circumstances, led them to abandon this most effective therapy. Read More

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http://dx.doi.org/10.1186/s40695-015-0008-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297993PMC
October 2015

Women's Midlife Health: Why the Midlife Matters.

Womens Midlife Health 2015 11;1. Epub 2015 Aug 11.

2Department of Epidemiology, Albert Einstein College of Medicine, Bronx, New York USA.

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http://dx.doi.org/10.1186/s40695-015-0006-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214213PMC

Depression in the menopause transition: risks in the changing hormone milieu as observed in the general population.

Authors:
Ellen W Freeman

Womens Midlife Health 2015 11;1. Epub 2015 Aug 11.

Department of Obstetrics/Gynecology and Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3701 Market Street, Suite 820 (Mudd Suite), Philadelphia, PA 19104 USA.

There is accumulating evidence but no definitive answers about the incidence of depressed mood in the menopause transition and its association with the changing hormonal milieu. While a changing hormonal milieu is the natural condition for all women, only a minority of mid-life women experience debilitating depressive symptoms or clinical depression. This review focuses on associations between depressed mood and the menopause transition, primarily as identified in longitudinal, population-based studies in the past decade. Read More

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http://dx.doi.org/10.1186/s40695-015-0002-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214217PMC

Recent evidence exploring the associations between physical activity and menopausal symptoms in midlife women: perceived risks and possible health benefits.

Womens Midlife Health 2015 11;1. Epub 2015 Aug 11.

4Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612 USA.

Although the health benefits of physical activity are well established, the prevalence of midlife women accumulating sufficient physical activity to meet current physical activity guidelines is strikingly low, as shown in United States (U.S.) based surveillance systems that utilize either (or both) participant-reported and device-based (i. Read More

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http://dx.doi.org/10.1186/s40695-015-0004-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214216PMC

Hormone therapy: a tale of two cancers - the potential of estrogen/selective estrogen receptor modulator combinations.

Authors:
Hugh S Taylor

Expert Rev Endocrinol Metab 2010 Sep;5(5):633-635

a Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, PO Box 208063, New Haven, CT 06520-8063, USA.

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http://dx.doi.org/10.1586/eem.10.56DOI Listing
September 2010

Early and premature menopause in women with diabetes mellitus Type 2.

Expert Rev Endocrinol Metab 2014 Jul 23;9(4):297-299. Epub 2014 May 23.

b Grupo de Investigación Salud de la Mujer, Asesor internacional, Orquédeas 1068, Dpto 302, Providencia 7510258, Santiago de Chile, Chile.

Those women who have early menopause have major cardiovascular and metabolic risk. The menopause below 40 years of age has been associated to increase in the risk of early beginning of osteoporosis, cardiovascular disease and diabetes mellitus, disorders characterized by hyperglycemia and glucose intolerance due to deficiency of insulin, decrease of the effectiveness of its action or both. The menopausal hormone therapy is the principal therapeutic tool, with the aim to contribute estrogens to suppress the clinical symptomatology and to make a favorably impact on the estrogen-dependent tissues. Read More

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http://dx.doi.org/10.1586/17446651.2014.922863DOI Listing

Prevalence of Low Bone Density and Comorbid Hypogonadism in Patients With Chronic Pancreatitis.

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

From the Division of Endocrinology, Department of Internal Medicine.

Objectives: Patients with chronic pancreatitis (CP) are at increased risk of low bone mineral density (BMD), although the prevalence of low BMD in patients with CP in the United States is lacking. We aimed to determine the prevalence of low BMD and identify potential risk factors, including hypogonadism and use of opioid medications, in subjects with CP in the United States.

Methods: This was a prospective, observational study. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001257DOI Listing
February 2019

Early menarche and premature natural menopause in Indonesia.

Ann Hum Biol 2018 Aug;45(5):419-427

b Portsmouth Brawijaya Centre for Global Health, Population and Policy , University of Brawijaya , Malang , Indonesia.

Background: An association has been suggested between early menarche and premature natural menopause. However, existing studies in developed countries show mixed findings.

Aim: This study examined whether early menarche (first menstrual period ≤11 years old) is a factor for premature natural menopause (final menstrual period <40 years old) in the context of a developing country. Read More

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http://dx.doi.org/10.1080/03014460.2018.1523461DOI Listing

Do psychosocial variables mediate the relationship between menopause symptoms and sexual function in middle-aged perimenopausal women?

J Obstet Gynaecol Res 2019 Feb 14. Epub 2019 Feb 14.

College of Nursing, Chonbuk Research Institute of Nursing Science, Chonbuk National University, Jeonju, South Korea.

Aim: To test a hypothetical path model evaluating the influence of menopause symptoms on sexual function among middle-aged perimenopausal women, as well as identify the mediating roles of body image, depression and sexual communication in this relationship.

Methods: We used a cross-sectional, correlational design. We included one exogenous variable (menopause symptoms) and four endogenous variables (body image, depression, sexual communication and sexual function) in the proposed model. Read More

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http://dx.doi.org/10.1111/jog.13927DOI Listing
February 2019

Genital Infections with Sodium Glucose Cotransporter-2 Inhibitors: Occurrence and Management in Patients with Type 2 Diabetes Mellitus.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):837-842

Medical Affairs, AstraZeneca Pharma India Ltd., Bengaluru, Karnataka, India.

Diabetes is a metabolic disorder characterized by hyperglycemia and is associated with several comorbidities and complications. Genital infection is one such complication that is often associated with diabetes mellitus (DM). Even though abnormalities in immune system, high urine glucose, and bladder dysfunction are important contributors for the increased risk of genitourinary symptoms, yet the possible role of pharmacologically induced glucosuria cannot be completely overlooked in such patients. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_159_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330876PMC
February 2019

Neighborhood disorder, exposure to violence, and perceived discrimination in relation to symptoms in midlife women.

Womens Midlife Health 2018 19;4:14. Epub 2018 Oct 19.

3Department of Anthropology, UMass Amherst, Amherst, MA USA.

Background: Some symptoms at midlife are associated with stress, such as hot flashes, trouble sleeping, headaches, or depressed mood. Hot flashes have been studied in relation to laboratory stressors, physiological biomarkers, and self-reported stress, but less is known about hot flashes in relation to the larger context of women's lives. This study examined the risk of symptoms in relation to neighborhood disorder, exposure to neighborhood violence, social cohesion and perceived discrimination. Read More

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http://dx.doi.org/10.1186/s40695-018-0043-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297945PMC
October 2018

Contraceptive challenges and the transgender individual.

Womens Midlife Health 2018 13;4:12. Epub 2018 Jul 13.

Clinical Instructor and Academic Faculty Scholar, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, 125 Paterson St, New Brunswick, NJ 08901 USA.

In recent years public awareness of healthcare disparities experienced by transgender individuals throughout the world have garnered increasing attention within the media and from health advocates. Despite this increasing awareness, a paucity of research data and clinical protocols of care for clinicians continues to exist, especially in regard to the transgender individual's family planning needs. Clinicians should be on the forefront of promoting strategies that forge a meaningful and collaborative relationship with the transgender man, including as he transitions through to the menopause and his sexual and reproductive healthcare needs. Read More

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http://dx.doi.org/10.1186/s40695-018-0042-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297942PMC

Stress and the menopausal transition in Campeche, Mexico.

Womens Midlife Health 2018 18;4. Epub 2018 Jun 18.

4Department of Anthropology, University of Hawai'i at Hilo, Hilo, HI USA.

Background: Stress has been implicated as a factor in the presence and severity of symptoms during the menopausal transition. Our primary aim was to test the hypothesis that stress-sensitive biological measures and self-reported stress would be positively associated with a greater likelihood and intensity of hot flashes. Our secondary aim was to examine measures of stress in relation to the most often reported symptoms in Campeche, Mexico. Read More

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http://dx.doi.org/10.1186/s40695-018-0038-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298015PMC

The challenges of midlife women: themes from the Seattle midlife Women's health study.

Womens Midlife Health 2018 15;4. Epub 2018 Jun 15.

3Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, Wahsington USA.

Background: Midlife, the period of the lifespan between younger and older adulthood, has been described as a period of transition in women's lives. Investigators studying midlife have focused on women 40 to 65 years of age, who typically experience multiple social, psychological and biological challenges, among them the menopausal transition. Investigators have reported a diverse array of stressful events, for example, health concerns, family problems, work-related issues, deaths, frustrated goal attainment, and financial worries; however, none have identified which life events midlife women experience as the most salient. Read More

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http://dx.doi.org/10.1186/s40695-018-0039-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298022PMC

Prophylactic salpingo-oophorectomy & surgical menopause for inherited risks of cancer: the need to identify biomarkers to assess the theoretical risk of premature coronary artery disease.

Womens Midlife Health 2018 27;4. Epub 2018 Apr 27.

1Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Health Research Innovation Centre, GB42, 3280 Hospital Dr NW, Calgary, AB T2N 4Z6 Canada.

Background: Some women with genetic risk of breast and/or ovarian cancer (e.g., BRCA1/2) opt to undergo prophylactic salpingo-oophorectomy (PSO, or surgical removal of the ovaries & fallopian tubes) in order to reduce their risk of cancer. Read More

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http://dx.doi.org/10.1186/s40695-018-0037-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297996PMC

Bone mineral density in midlife long-term users of hormonal contraception in South Africa: relationship with obesity and menopausal status.

Womens Midlife Health 2018 10;4. Epub 2018 Apr 10.

1MatCH Research Unit [Maternal, Adolescent and Child Health Research Unit], Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University of the Witwatersrand, 40 Dr AB Xuma Street,11th floor, Suite 1108-9,Commercial City, Durban, 4001 South Africa.

Background: In South Africa, hormonal contraception is widely used in women over the age of 40 years. One of these methods and the most commonly used is depot-medroxyprogesterone acetate (DMPA) which has been found to have a negative effect on bone mass. Limited information is available on the effect of norethisterone enanthate (NET-EN) on bone mass, and combined oral contraceptives (COCs) have not been found to be associated with loss of bone mass. Read More

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http://dx.doi.org/10.1186/s40695-018-0035-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297953PMC

Is in utero exposure to maternal socioeconomic disadvantage related to offspring ovarian reserve in adulthood?

Womens Midlife Health 2018 16;4. Epub 2018 Mar 16.

6Department of Obstetrics, Gynecology, & Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143 USA.

Background: Because the ovarian follicle pool is established in utero, adverse exposures during this period may be especially impactful on the size and health of the initial follicle endowment, potentially shaping trajectories of ovarian follicle loss and the eventual onset of menopause. Building on a robust literature linking socioeconomic status (SES) and menopausal timing, the current study examined adverse prenatal exposures related to maternal SES, hypothesizing that greater maternal socioeconomic disadvantage would be associated with lower ovarian reserve in the adult offspring.

Methods: In a healthy, community-based sub-sample ( = 350) of reproductive age participants in the OVA Study (2006-2011), prenatal maternal SES was examined in relation to two biomarkers of ovarian reserve, antimullerian hormone (AMH) and antral follicle count (AFC). Read More

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http://dx.doi.org/10.1186/s40695-018-0033-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297989PMC

Work outcomes in midlife women: the impact of menopause, work stress and working environment.

Womens Midlife Health 2018 9;4. Epub 2018 Apr 9.

1Department Psychology (at Guy's), Institute of Psychiatry, Psychology and Neuroscience, Kings College London, 5th Floor Bermondsey Wing, Guy's Campus, London, SE1 9RT UK.

Background: There is growing research interest in the question of whether menopause impacts upon mid-aged women's work outcomes, but the evidence to date is inconclusive. This paper examines whether: (i) menopausal status, and experience of hot flushes and night sweats (HFNS), and whether (ii) work stress and work environment, are associated with work outcomes (absenteeism, job performance, turnover intention, and intention to leave the labor force).

Methods: An online survey (sociodemographic, menopause, health, well-being and aspects of work) was completed by 216 (pre-, peri- and postmenopausal) women aged 45-60 years. Read More

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http://dx.doi.org/10.1186/s40695-018-0036-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298001PMC

The role of smoking in the relationship between intimate partner violence and age at natural menopause: a mediation analysis.

Womens Midlife Health 2018 15;4. Epub 2018 Jan 15.

2Research Centre for Generational Health and Ageing, The University of Newcastle, Callaghan, NSW Australia.

Background: Age at natural menopause (ANM) is considered as a biologic marker of health and ageing. The relationship between intimate partner violence (IPV) and ANM is currently unknown, and whether smoking plays a role in this relationship is unclear. The aim of this study was to examine the association between IPV and ANM and to quantify the effect mediated through smoking. Read More

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http://dx.doi.org/10.1186/s40695-017-0031-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297990PMC
January 2018

Genitourinary syndrome of menopause treatment using lasers and temperature-controlled radiofrequency.

Prz Menopauzalny 2018 Dec 31;17(4):180-184. Epub 2018 Dec 31.

3 Chair and Department of Gynaecology, Medical University of Lublin, Lublin, Poland.

Perimenopausal changes caused by oestrogen deficiency are accompanied by a decrease in the content of collagen and elastin in the tissues, leading to thinning of the epithelium and the resultant disappearance of the superficial layer, which leads to smooth muscle dysfunction as well as connective tissue degradation. This aetiopathogenetic chain results in a set of symptoms experienced by approximately 50% of women in the peri- and postmenopausal period. Symptoms of dryness, burning, dyspareunia and urgency contribute to a significant reduction in the quality of sexual function and general comfort of life due to recurrent infections of the vagina, vulva and urinary tract. Read More

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http://dx.doi.org/10.5114/pm.2018.81743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372847PMC
December 2018

Selected vitamins and quality of life in menopausal women.

Prz Menopauzalny 2018 Dec 31;17(4):175-179. Epub 2018 Dec 31.

3 Chair and Department of Gynaecology, Medical University of Lublin, Lublin, Poland.

The article presents the results of the latest studies on the correlation between the levels of selected vitamins, their bio-availability and their influence on bodily tissues and the quality of life in menopausal women. It also discusses the correlations between vitamin concentrations and the incidence of diseases characteristic of the transitional period, which affects the quality of life. Read More

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http://dx.doi.org/10.5114/pm.2018.81742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372850PMC
December 2018

Genitourinary syndrome of menopause - is the problem solved? State of the art 2018.

Prz Menopauzalny 2018 Dec 31;17(4):168-174. Epub 2018 Dec 31.

1 Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, Warsaw, Poland.

Vulvovaginal atrophy accompanied by lower urinary tract dysfunction related to low levels of estrogen and androgens is labeled as genitourinary syndrome of menopause (GSM). Although this condition affects most postmenopausal women worldwide, it seems to be underdiagnosed and undertreated. Women should be properly advised to choose an adequate treatment modality to improve their quality of life, sexual relationships and social activity. Read More

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http://dx.doi.org/10.5114/pm.2018.81741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372854PMC
December 2018

Effects of six weeks of resistance-endurance training on microRNA-29 expression in the heart of ovariectomised rats.

Prz Menopauzalny 2018 Dec 30;17(4):155-160. Epub 2018 Dec 30.

Nutrition and Physical Activity Laboratory, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile.

Introduction: Heart disease risk rises with age. However, women's symptoms become more pronounced following the onset of menopause. The aim of the present study was to evaluate the effects of six weeks of combined resistance-endurance (RE) training on microRNA-29 expression in the heart of ovariectomised rats. Read More

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http://dx.doi.org/10.5114/pm.2018.81737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372852PMC
December 2018

Diagnostic value of histopathological examination results obtained during screening of patients with diagnosed atypical hyperplasia.

Prz Menopauzalny 2018 Dec 31;17(4):144-148. Epub 2018 Dec 31.

Department of Operative Gynecology, Endoscopy and Gynecologic Oncology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.

Vulvovaginal atrophy accompanied by lower urinary tract dysfunction related to low levels of estrogen and androgens is labeled as genitourinary syndrome of menopause (GSM). Although this condition affects most postmenopausal women worldwide, it seems to be underdiagnosed and undertreated. Women should be properly advised to choose an adequate treatment modality to improve their quality of life, sexual relationships and social activity. Read More

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http://dx.doi.org/10.5114/pm.2018.81734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372849PMC
December 2018

Effects of aging and menopause on pancreatic fat fraction in healthy women population: A strobe-compliant article.

Medicine (Baltimore) 2019 Feb;98(7):e14451

Department of Gastroenterology.

Pancreatic fat fraction has been shown to increase in many pathological situations. However, pancreatic fat fraction and its physiological changes in healthy women are still unclear. The aim of this study is to investigate the effect of aging and menopause on pancreatic fat fraction in healthy female population. Read More

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http://dx.doi.org/10.1097/MD.0000000000014451DOI Listing
February 2019

Ovarian surgery and follicular reserve.

Expert Rev Endocrinol Metab 2006 Nov;1(6):743-752

a Professor, University Hospitals Schleswig-Holstein, Campus Kiel, Department of Obstetrics and Gynecology, Michaelisstr. 16, 24105 Kiel, Germany.

In patients with cystic ovarian pathology, such as endometriomas, polycystic ovary syndrome, teratomas or benign tumors, there is a tendency towards abnormal ovarian function. Anovulation and sterility may occur. This review will summarize the normal physiology of the female gonad and the development of oogenesis from initial reproductive age to the menopause. Read More

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http://dx.doi.org/10.1586/17446651.1.6.743DOI Listing
November 2006
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An epidemiological overview of the relationship between hormone replacement therapy and breast cancer.

Expert Rev Endocrinol Metab 2011 May;6(3):397-409

b National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT, 0200 Australia.

Large-scale randomized clinical trials and observational studies have consistently found that use of hormone replacement therapy (HRT) increases the risk of breast cancer. More recently, ecological studies have shown correlations between dramatic reductions in use of HRT in many countries, and declines in the rates of breast cancer in older women. Meta-analyses of data from the trials and observational studies show that the increase in breast cancer risk is greater for combined estrogen-progestin therapies compared with estrogen alone; that for both types of preparation, breast cancer risk increases with duration of use; and that the risks decrease relatively quickly after cessation of use. Read More

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http://dx.doi.org/10.1586/eem.11.31DOI Listing

Roles of peptides and steroids in sleep disorders.

Authors:
Axel Steiger

Expert Rev Endocrinol Metab 2006 Sep;1(5):609-622

a Max Planck Institute of Psychiatry, Department of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany.

A bidirectional interaction exists between the electrophysiological and neuroendocrine components of sleep. The first is represented by the nonrapid eye movement sleep (NREMS) and rapid eye movement sleep (REMS) cycles, the latter by distinct patterns of the secretion of various hormones. Certain hormones (neuropeptides and steroids) play a specific role in sleep regulation. Read More

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http://dx.doi.org/10.1586/17446651.1.5.609DOI Listing
September 2006

DDT and Breast Cancer: Prospective Study of Induction Time and Susceptibility Windows.

J Natl Cancer Inst 2019 Feb 13. Epub 2019 Feb 13.

Background: In a previous Child Health and Development Studies report, p, p'-DDT was associated with a fivefold increased risk of premenopausal (before age 50 years) breast cancer for women first exposed before puberty. Here we extend our observation to breast cancer diagnosed during early postmenopause (ages 50-54 years) to determine whether age at diagnosis modifies the interaction of DDT with age at exposure.

Methods: We conducted a second prospective, nested case-control study in the Child Health and Development Studies (153 incident breast cancer cases diagnosed at ages 50-54 years and 432 controls matched to cases on birth year). Read More

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http://dx.doi.org/10.1093/jnci/djy198DOI Listing
February 2019

Depression during perimenopause: the role of the obstetrician-gynecologist.

Arch Womens Ment Health 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, University of Washington School of Medicine, 1959 NE Pacific St., Box 356460, Seattle, WA, 98195-6460, USA.

Depression in women is more common during perimenopause (the transition to menopause) than at other times in the life cycle. Symptoms of depression may be different in perimenopausal women compared to younger or older women, and are often dismissed as part of normal menopause. This is an expert narrative review. Read More

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http://link.springer.com/10.1007/s00737-019-0950-6
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http://dx.doi.org/10.1007/s00737-019-0950-6DOI Listing
February 2019
2 Reads

Antiresorptive and anabolic agents in the prevention and reversal of bone fragility.

Nat Rev Rheumatol 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine and St Vincent's Institute, University of Melbourne, Melbourne, Victoria, Australia.

Bone volume, microstructure and its material composition are maintained by bone remodelling, a cellular activity carried out by bone multicellular units (BMUs). BMUs are focally transient teams of osteoclasts and osteoblasts that respectively resorb a volume of old bone and then deposit an equal volume of new bone at the same location. Around the time of menopause, bone remodelling becomes unbalanced and rapid, and an increased number of BMUs deposit less bone than they resorb, resulting in bone loss, a reduction in bone volume and microstructural deterioration. Read More

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http://dx.doi.org/10.1038/s41584-019-0172-3DOI Listing
February 2019

Role of sex in post-transplant diabetes mellitus development: Are men and women equal?

J Diabetes Complications 2019 Jan 4. Epub 2019 Jan 4.

Ist Department of Internal Diseases, University Hospital Martin and Jessenius Medical Faculty of Comenius University, Slovak Republic.

Introduction: Sex differences are defined as biology-linked differences between women and men that occur through the sex chromosomes and their effects on organ systems.

Material And Methods: The objective of this prospective study was to determine risk factors for post-transplant diabetes mellitus (PTDM) in men and women.

Results: A total of 417 patients (271 men and 146 women) were included in the monitored group. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.017DOI Listing
January 2019

Urogynecological effects of menopause.

Expert Rev Endocrinol Metab 2014 Jan 13;9(1):73-77. Epub 2013 Dec 13.

a Birmingham Women's Hospital, Mindelsohn Way, Edgbaston, Birmingham, West Midlands, B15 2TG, UK.

The menopause signifies a period after significant hormonal change that affects all estrogen-sensitive tissues. This change may result in symptoms affecting any part of the urogenital system. These changes can significantly affect women's health and quality of life. Read More

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http://www.tandfonline.com/doi/full/10.1586/17446651.2014.86
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http://dx.doi.org/10.1586/17446651.2014.866893DOI Listing
January 2014
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Rotating night shift work and menopausal age.

Hum Reprod 2019 Feb 12. Epub 2019 Feb 12.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Study Question: How are rotating night shift schedules associated with age at menopause among a large, national cohort of shift working nurses?

Summary Answer: Our findings suggest that working rotating night shifts with sufficient frequency may modestly accelerate reproductive senescence among women who may already be predisposed to earlier menopause.

What Is Known Already: Younger age at menopause has been associated with increased risk of adverse health outcomes, particularly those linked to reproduction. Night work has been associated with reproductive dysfunction, including disruption of menstrual cycle patterns. Read More

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http://dx.doi.org/10.1093/humrep/dey390DOI Listing
February 2019
1 Read

Hormone replacement therapy: changes in prescribing practice.

BMJ 2019 Feb 11;364:l633. Epub 2019 Feb 11.

British Menopause Society Medical Advisory Council, British Menopause Society, Spracklen House, Marlow SL7 2QH, UK.

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http://dx.doi.org/10.1136/bmj.l633DOI Listing
February 2019
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Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism.

Curr Biol 2019 Jan 29. Epub 2019 Jan 29.

Department of Biology, University of Washington, Seattle, WA 98195, USA. Electronic address:

Successful reproduction in female mammals is precisely timed and must be able to withstand the metabolic demand of pregnancy and lactation. We show that kisspeptin-expressing neurons in the arcuate hypothalamus (Kiss1) of female mice control the daily timing of food intake, along with the circadian regulation of locomotor activity, sleep, and core body temperature. Toxin-induced silencing of Kiss1 neurons shifts wakefulness and food consumption to the light phase and induces weight gain. Read More

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http://dx.doi.org/10.1016/j.cub.2019.01.022DOI Listing
January 2019

Limits to Fitness Benefits of Prolonged Post-reproductive Lifespan in Women.

Curr Biol 2019 Jan 29. Epub 2019 Jan 29.

Department of Biology, University of Turku, 20014 Turku, Finland.

Recent advances in medicine and life-expectancy gains have fueled multidisciplinary research into the limits of human lifespan [1-3]. Ultimately, how long humans can live for may depend on selection favoring extended longevity in our evolutionary past [4]. Human females have an unusually extended post-reproductive lifespan, which has been explained by the fitness benefits provided from helping to raise grandchildren following menopause [5, 6]. Read More

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http://dx.doi.org/10.1016/j.cub.2018.12.052DOI Listing
January 2019
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The relationship between menopausal symptoms and metabolic syndrome in postmenopausal women.

J Obstet Gynaecol 2019 Feb 11:1-5. Epub 2019 Feb 11.

a Department of Obstetrics and Gynecology , University of Health Sciences Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital , Istanbul , Turkey.

The most common symptoms during menopausal transition and menopause are vasomotor symptoms. We aimed to investigate the relationship between menopausal symptoms and metabolic syndrome (MetS) in postmenopausal women. Two hundred and fifty-four and 317 postmenopausal women were in the MetS and non-MetS groups, respectively. Read More

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http://dx.doi.org/10.1080/01443615.2018.1534812DOI Listing
February 2019
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The clinical role of LASER for vulvar and vaginal treatments in gynecology and female urology: An ICS/ISSVD best practice consensus document.

Neurourol Urodyn 2019 Feb 11. Epub 2019 Feb 11.

Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa.

Background: The clinical role of LASER for vulvar and vaginal treatments in gynecology and female urology is controversial.

Aims: In this best practice document, we propose recommendations for the use of LASER for gynecologic and urologic conditions such as vulvovaginal atrophy, urinary incontinence, vulvodynia, and lichen sclerosus based on a thorough literature review.

Materials & Methods: This project was developed between January and September 2018. Read More

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http://doi.wiley.com/10.1002/nau.23931
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http://dx.doi.org/10.1002/nau.23931DOI Listing
February 2019
6 Reads

Prospective observational study to evaluate the efficacy and safety of the pollen extract Sérélys in the management of women with menopausal symptoms.

Gynecol Endocrinol 2019 Feb 10:1-4. Epub 2019 Feb 10.

b Exeltis Healthcare , Ismaning , Germany.

Safety concerns or contraindications to the use of hormones have resulted in a rise of the use of herbal medicinal products for the management of menopausal symptoms. The pollen extract Sérélys represents, due to its ingredients and mode of action, a new and innovative alternative for the management of these symptoms. The aim of the present study was to demonstrate the efficacy and safety of Sérélys. Read More

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http://dx.doi.org/10.1080/09513590.2018.1538347DOI Listing
February 2019
1 Read

Twist1 was detected in mesenchymal cells of mammary fibroadenoma and invasive components of breast carcinoma in rats.

J Toxicol Pathol 2019 Jan 1;32(1):19-26. Epub 2018 Sep 1.

Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.

Fibroadenoma (FA) is a common mammary fibroepithelial tumor. The tumor size of the FA is increased by estrogen, progesterone, prolactin, and pregnancy, whereas it decreases after menopause. These observations in humans indicate that FA is hormone dependent. Read More

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http://dx.doi.org/10.1293/tox.2018-0029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361665PMC
January 2019
1 Read