66,183 results match your criteria Menopause Management[Journal]


Effects of pregnancy experience on ovarian senescence and longevity in Hatano rats bred for high- and low-avoidance learning.

Exp Gerontol 2018 Dec 13. Epub 2018 Dec 13.

Hatano Research Institute, Food and Drug Safety Center, 729-5 Ochiai, Hadano, Kanagawa 257-8523, Japan.

We investigated the effects of pregnancy experience on ovarian senescence and longevity using two inbred strains of Hatano rats. These strains have been selectively bred for high- and low-avoidance animals (HAA and LAA, respectively), but the HAA line has a slower onset of ovarian senescence and a shorter lifespan compared with the LAA line. The onset of abnormal estrous cycles and survival curves were compared between nulliparous and parous rats in each line. Read More

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December 2018

Higher symptom burden is associated with lower function in women taking adjuvant endocrine therapy for breast cancer.

J Geriatr Oncol 2018 Dec 12. Epub 2018 Dec 12.

Medical Oncology, Duke University Medical Center, Durham, NC 27710, United States. Electronic address:

Objective: To explore the impact of symptoms on physical function in women on adjuvant endocrine therapy for breast cancer.

Methods: Eligible women were postmenopausal, had hormone receptor positive, stage I-IIIA breast cancer, completed surgery, chemotherapy, radiation, and on adjuvant endocrine therapy. At a routine follow-up visit, women (N = 107) completed standardized symptom measures: Brief Fatigue Inventory, Brief Pain Inventory, Menopause Specific Quality of Life Questionnaire, Functional Assessment of Cancer Therapy Neurotoxicity scales. Read More

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December 2018

Determinants of pulse pressure amplification in hypertensive and diabetic patients.

Hypertens Res 2018 Dec 14. Epub 2018 Dec 14.

Paris-Descartes University; Diagnosis and Therapeutic Center, Hypertension and Cardiovascular Prevention Unit, Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

Hypertensive diabetic patients remain at high cardiovascular risk despite adequate blood pressure and glycemic control. Pulse pressure amplification (PPA) is expressed as the peripheral-to-central PP ratio and provides complementary information for use in assessing cardiovascular risk. The aim of our study was to determine the clinical and biological determinants of PPA in hypertensive and diabetic patients. Read More

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December 2018

Chrysin (5,7-dihydroxyflavone) exerts anxiolytic-like effects through GABA receptors in a surgical menopause model in rats.

Biomed Pharmacother 2019 Jan 30;109:2387-2395. Epub 2018 Nov 30.

Facultad de Ciencias Químicas, Universidad Veracruzana, Orizaba, Veracruz, Mexico.

The present study investigated the effects of the flavonoid chrysin (5,7-dihydroxyflavone) on anxiety-like behavior in rats in a model of surgical menopause and evaluated the participation of γ-aminobutyric acid-A (GABA) receptors in these actions. At 12 weeks post-ovariectomy, the effects of different doses of chrysin (0.5, 1, 2, and 4 mg/kg) were evaluated in the elevated plus maze, light/dark test, and locomotor activity test, and comparisons were made with the clinically effective anxiolytic diazepam. Read More

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January 2019

Impact of sex and reproductive status on memory circuitry structure and function in early midlife using structural covariance analysis.

Hum Brain Mapp 2018 Dec 12. Epub 2018 Dec 12.

Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Research on age-related memory alterations traditionally targets individuals aged ≥65 years. However, recent studies emphasize the importance of early aging processes. We therefore aimed to characterize variation in brain gray matter structure in early midlife as a function of sex and menopausal status. Read More

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December 2018

The relationship between epicardial adipose tissue and coronary artery stenosis by sex and menopausal status in patients with suspected angina.

Biol Sex Differ 2018 Dec 14;9(1):52. Epub 2018 Dec 14.

Division of Cardiology, Korea University Medical Center, Anam hospital, Seoul, South Korea.

Background: Evidence suggests that epicardial adipose tissue (EAT) is closely related to coronary artery stenosis (CAS). However, sexual dimorphism may be present in adipose tissue, and its influence on CAS between men and women is controversial. We assessed the relationship between EAT and CAS by sex and menopausal status in patients with suspected angina. Read More

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December 2018

Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice.

Geroscience 2018 Dec 13. Epub 2018 Dec 13.

Department of Animal, Dairy and Veterinary Sciences, Center for Integrated BioSystems, School of Veterinary Medicine, Utah State University, 4700 Old Main Hill, Logan, UT, 84322, USA.

Cardiovascular disease, rare in premenopausal women, increases sharply at menopause and is typically accompanied by chronic inflammation. Previous work in our laboratory demonstrated that replacing senescent ovaries in post-reproductive mice with young, actively cycling ovaries restored many health benefits, including decreased cardiomyopathy and restoration of immune function. Our objective here was to determine if depletion of germ cells from young transplanted ovaries would alter the ovarian-dependent extension of life and health span. Read More

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December 2018

Mate Choice and the Persistence of Maternal Mortality.

Reprod Sci 2018 Dec 13:1933719118812730. Epub 2018 Dec 13.

1 Department of Biology, McMaster University, Hamilton, Canada. Santosh Jagadeeshan is now with the Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada.

Maternal mortality remains one of the leading causes of death in women of reproductive age in developing countries, and a major concern in some developed countries. It is puzzling why such a condition has not been reduced in frequency, if not eliminated, in the course of evolution. Maternal mortality is a complex phenomenon caused by several physiological and physical factors. Read More

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December 2018

Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females.

Brain Sci 2018 Dec 7;8(12). Epub 2018 Dec 7.

Departamento de Ciencias Médicas, Universidad de Guanajuato, León, Guanajuato 37320, Mexico.

Polymorphisms of the estrogen receptor and genes have been linked with cognitive deficits and affective disorders. The effects of these genetic variants on emotional processing in females with low estrogen levels are not well known. The aim was to explore the impact of the and genes on the responses to the facial emotion recognition task in females. Read More

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December 2018

Menopause and work: an overview of UK guidance.

Occup Med (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Division of Psychiatry and Applied Psychology, School of Medicine, Institute of Mental Health, University of Nottingham Innovation Park, Triumph Road, Nottingham, UK.

Background: Recent evidence suggests that some women experience menopausal symptoms that impact on their working lives, and that work environments can impact upon the experience of menopause. As a result, guidance for employers and other key stakeholders about this potential occupational health issue has emerged. To date there has not been a review of these documents to identify their main recommendations for policy and practice. Read More

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December 2018

Is there a relationship between restless legs syndrome and medical problems in pregnant women? A cross-sectional study in Iran.

Acta Neurol Belg 2018 Dec 12. Epub 2018 Dec 12.

Midwifery Department, Menopause Andropause Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

This study aimed to assess the relationship between RLS and medical problems among pregnant women. In this study, 700 pregnant women were recruited. A socio-demographic questionnaire and the International Restless Legs Questionnaire were used to gather information. Read More

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December 2018
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Fragile X Associated Primary Ovarian Insufficiency (FXPOI): Case Report and Literature Review.

Front Genet 2018 27;9:529. Epub 2018 Nov 27.

Sheba Medical Center, Tel Hashomer and Tel Aviv University, Tel Aviv, Israel.

Abnormalities in the X-linked gene are associated with a constellation of disorders, which have broad and profound implications for the person first diagnosed, and extended family members of all ages. The rare and pleiotropic nature of the associated disorders, both common and not, place great burdens on (1) the affected families, (2) their care providers and clinicians, and (3) investigators striving to conduct research on the conditions. Fragile X syndrome, occurring more severely in males, is the leading genetic cause of intellectual disability. Read More

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November 2018

25-Hydroxyvitamin D serum levels in rheumatic female patients in southeast Spain: The paradigm of daily optimal sunshine levels and inadequate vitamin D status.

Endocrinol Diabetes Nutr 2018 Dec 9. Epub 2018 Dec 9.

Scientific Direction, Gador SA, Buenos Aires, Argentina.

Background: Almeria is a region in southeast Spain with optimal sunlight levels, along with low pluvial and pollution rates. If exposure to sunlight is sufficient to maintain adequate levels of vitamin D (25OHD), this population should display high serum levels.

Objectives: To describe 25OHD serum status in women from Almeria and evaluate the impact of long sunlight exposure along the seasons on 25OHD. Read More

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December 2018

Impact of diabetes mellitus on epithelial ovarian cancer survival.

BMC Cancer 2018 Dec 12;18(1):1246. Epub 2018 Dec 12.

Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Diabetes mellitus (DM) is associated with poorer outcomes in some cancers. Its effect on ovarian cancer is less clear. We consider the effect of DM on overall survival (OS) and progression free survival (PFS) in patients with epithelial ovarian cancer (EOC). Read More

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December 2018
3.362 Impact Factor

Distribution of Paraoxonase-1 (PON-1) and Lipoprotein Phospholipase A2 (Lp-PLA2) across Lipoprotein Subclasses in Subjects with Type 2 Diabetes.

Oxid Med Cell Longev 2018 5;2018:1752940. Epub 2018 Nov 5.

Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.

Paraoxonase-1 (PON1) and lipoprotein phospholipase A2 (Lp-PLA2) may exert an important protective role by preventing the oxidative transformation of high- and low-density lipoproteins (HDL and LDL, respectively). The activity of both enzymes is influenced by lipidome and proteome of the lipoprotein carriers. T2DM typically presents significant changes in the molecular composition of the lipoprotein subclasses. Read More

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November 2018

IUGA committee opinion: laser-based vaginal devices for treatment of stress urinary incontinence, genitourinary syndrome of menopause, and vaginal laxity.

Int Urogynecol J 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics and Gynecology, The American University of Beirut, Beirut, Lebanon.

This committee opinion reviews the laser-based vaginal devices for treatment of genitourinary syndrome of menopause, vaginal laxity, and stress urinary incontinence. The United States Food and Drug Administration has issued a warning for unsubstantiated advertising and use of energy-based devices. Well-designed case-control studies are required to further investigate the potential benefits, harm, and efficacy of laser therapy in the treatment of genitourinary syndrome of menopause, vaginal laxity, and stress urinary incontinence. Read More

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December 2018

Increased Alzheimer's risk during the menopause transition: A 3-year longitudinal brain imaging study.

PLoS One 2018 12;13(12):e0207885. Epub 2018 Dec 12.

Departments of Pharmacology and Neurology, College of Medicine, University of Arizona, Tucson, United States of America.

Two thirds of all persons with late-onset Alzheimer's disease (AD) are women. Identification of sex-based molecular mechanisms underpinning the female-based prevalence of AD would advance development of therapeutic targets during the prodromal AD phase when prevention or delay in progression is most likely to be effective. This 3-year brain imaging study examines the impact of the menopausal transition on Alzheimer's disease (AD) biomarker changes [brain β-amyloid load via 11C-PiB PET, and neurodegeneration via 18F-FDG PET and structural MRI] and cognitive performance in midlife. Read More

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December 2018

Estradiol vaginal inserts (Imvexxy): effective in genitourinary syndrome of menopause without increasing systemic estrogen levels.

Authors:
D M Paton

Drugs Today (Barc) 2018 Nov;54(11):667-677

Professor Emeritus of Pharmacology, University of Auckland, Auckland, New Zealand.

Many women suffer from the genitourinary syndrome of the menopause (GSM), in particular pathological changes that occur in the vagina due to the reduction in their production of estrogens. TherapeuticsMD has developed Imvexxy, small softgel capsules that contain solubilized estradiol and that are inserted vaginally by women twice a week, every 3 to 4 days. These vaginal inserts have been found to readily supply estradiol to the vagina and to result in significant improvement in the GSM signs and symptoms these women had been experiencing. Read More

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November 2018

Dual Targeting of Bile Acid Receptor-1 (TGR5) and Farnesoid X Receptor (FXR) Prevents Estrogen-Dependent Bone Loss in Mice.

J Bone Miner Res 2018 Dec 7. Epub 2018 Dec 7.

East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Department of orthopedic oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.

Osteoporosis is a global bone disease characterized by reduced bone mineral density (BMD) and increased risk of fractures. The risk of developing osteoporosis increases with aging, especially after menopause in women. Discovering the signaling pathways which play a significant role in aging- and menopause-induced osteoporosis should accelerate osteoporosis drug discovery. Read More

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December 2018
6.832 Impact Factor

Effect of experimentally induced hypertension on cerebellum of postmenopausal rat.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Physiology, Faculty of Medicine, Minia University, Minia, Egypt.

Cerebellum seems to be a specific target for both the decrease of estrogen and hypertension in menopause. The aim of this study was to investigate the hypertension and menopause-induced changes in rat's cerebellar cortex and the possible mechanisms of these changes. Rats were divided into four groups: the sham-operated control (SC-group), the ovariectomized (OVX-group), the hypertensive (H-group), and the ovariectomized-hypertensive (OVX-H-group) group. Read More

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December 2018
4 Reads

Description of Ovariectomy Protocol in Mice.

Methods Mol Biol 2019 ;1916:303-309

Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo, Diadema, SP, Brazil.

Estrogen and ovarian function decline are relevant characteristics of menopause period. Numerous physiological, metabolic and immunological alterations in the female body occur in the menopause period and some of these changes remain uncertain. The animal model that mimics menopause phase is an important approach to better comprehend the biological process involved in this period of women life. Read More

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January 2019
3 Reads

Hysterectomy Uniquely Impacts Spatial Memory in a Rat Model: A Role for the Nonpregnant Uterus in Cognitive Processes.

Endocrinology 2019 Jan;160(1):1-19

Department of Psychology, Arizona State University, Tempe, Arizona.

Approximately one-third of women experience hysterectomy, or the surgical removal of the uterus, by 60 years of age, with most surgeries occurring prior to the onset of natural menopause. The ovaries are retained in about half of these surgeries, whereas for the other half hysterectomy occurs concurrently with oophorectomy. The dogma is that the nonpregnant uterus is dormant. Read More

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January 2019

Is menstrual Psychosis a Forgotten Entity?

Indian J Psychol Med 2018 Nov-Dec;40(6):574-576

Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

The connection between menstruation and psychosis has been recognized since the 18 Century. However, there are few case reports available in modern times describing about 30 patients with this condition. The psychosis may occur in the premenstrual phase in some patients and in others it begins with the onset of menses. Read More

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December 2018

[Evaluación funcional de deglución-aspiración en pacientes sometidos a laringectomía subtotal supracricoidea con cricohioidoepiglotopexia].

Gac Med Mex 2018 ;154(6):645-648

Hospital de Oncología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.

Introduction: Cardiovascular disease is the main cause of mortality worldwide. In women, its incidence increases at the sixth decade of life, coinciding with postmenopause. Whether this effect is due to menopause-related hormonal changes is not known. Read More

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January 2018

[Asociación del estado hormonal con el riesgo cardiovascular evaluado por Globorisk en mujeres mexicanas].

Gac Med Mex 2018 ;154(6):638-644

Secretaría de Salud, Hospital General de México, Departamento de Medicina Interna. Ciudad de México, México.

Introduction: Cardiovascular disease is the main cause of mortality worldwide. In women, its incidence increases at the sixth decade of life, coinciding with postmenopause. Whether this effect is due to menopause-related hormonal changes is not known. Read More

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January 2018

Epidemiology and Risk Factors of Menopause Syndrome Among Uyghur, Han, and Kazak Women in Xinjiang, China.

Med Sci Monit 2018 Dec 10;24:8950-8958. Epub 2018 Dec 10.

Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).

BACKGROUND This study analyzed the epidemiology and the risk factors of menopause syndrome (MPS) among Uyghur, Han, and Kazak women in Xinjiang. MATERIAL AND METHODS This was a cross-sectional study. The stratified-cluster random-sampling method was used. Read More

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December 2018

The WISDOM survey: toward wiser care of women with vulvovaginal atrophy.

Authors:
Jan L Shifren

Menopause 2018 Dec 10. Epub 2018 Dec 10.

Massachusetts General Hospital, Boston, MA.

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December 2018

Can the use of probiotics in association with isoflavone improve the symptoms of genitourinary syndrome of menopause? Results from a randomized controlled trial.

Menopause 2018 Dec 10. Epub 2018 Dec 10.

Department of Obstetrics and Gynecology, State University of Campinas (UNICAMP - Universidade Estadual de Campinas), Campinas, São Paulo, Brazil.

Objective: To evaluate the effect of isoflavone administration, either in conjunction with probiotic use or not, on the symptoms of genitourinary syndrome of menopause, and compare the effects with those of hormone therapy.

Methods: A randomized clinical trial was conducted on 60 postmenopausal women aged 40 to 60 years, randomly assigned to receive oral isoflavone (150 mg dry extract of glycine max) alone or isoflavone plus probiotic (Lactobacillus acidophilus, Lactobacillus casei, Lactococcus lactis, Bifidobacterium bifidum, and Bifidobacterium lactis) or hormone therapy (1 mg estradiol and 0.5 mg norethisterone acetate). Read More

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December 2018

Women's experience of vulvovaginal symptoms associated with menopause.

Menopause 2018 Dec 10. Epub 2018 Dec 10.

New England Research Institutes, Inc., Watertown, MA.

Objective: This study describes women's experiences of the genitourinary syndrome of menopause (GSM) elicited through focus groups and cognitive debriefing sessions during development of a novel patient-reported outcome measure (PROM) designed for use in both clinical care and research.

Methods: A draft questionnaire to identify and assess bothersome genitourinary symptoms associated with estrogen deficiency in menopausal women was developed in five discrete phases from multiple sources of information in accordance with standards for PROM development. GSM was confirmed by report of symptoms in conjunction with a confirmatory pelvic examination and laboratory assessments. Read More

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December 2018

Self-awareness and the evaluation of hot flash severity: observations from the Seattle Midlife Women's Health Study.

Menopause 2018 Dec 10. Epub 2018 Dec 10.

School of Nursing, University of Washington, Seattle, WA.

Objective: The purpose of this study was to test the association of two dimensions of self-awareness with hot flash (HF) severity.

Methods: A subset of women from the Seattle Midlife Women's Health Study (N = 232) provided data for these analyses. Structural equation modeling was used to evaluate two dimensions of self-awareness (Internal States Awareness [ISA] and Self-Reflectiveness [SR]), and secondary factors of perceived stress, anxiety, and attitudes toward menopause as continuous with earlier life, health perceptions, and menopausal stage with respect to HF severity. Read More

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December 2018

Letter to the Editor To the Editor.

Authors:
David M Paton

Menopause 2018 Dec 10. Epub 2018 Dec 10.

Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, New Zealand.

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December 2018

The effect of a midwife-based counseling education program on sexual function in postmenopausal women: a randomized controlled clinical trial.

Menopause 2018 Dec 10. Epub 2018 Dec 10.

Department of Reproductive Health, Student Research Committee, School of Nursing & Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: The present study was conducted to investigate the effect of a midwife-based counseling education program on sexual function in postmenopausal women.

Methods: A randomized clinical trial was conducted on 52 eligible postmenopausal women. Participants' sexual function was assessed using the Female Sexual Function Index (FSFI). Read More

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December 2018

Factors related to age at menopause among Korean women: the Korean Longitudinal Survey of Women and Families.

Menopause 2018 Dec 10. Epub 2018 Dec 10.

College of Nursing & Ewha Research Institute of Nursing Science, Ewha Womans University Seodaemun-gu, Seoul, South Korea.

Objective: The purpose of this study was to explore factors influencing age of menopause among Korean women.

Methods: For this secondary analysis study, panel data for Waves 4 through 6 of the Korean Longitudinal Survey of Women were used. Women aged 40 to 60 who were menstruating at Wave 4 were included in the analysis (N = 5,437). Read More

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December 2018

Ovarian protection with gonadotropin-releasing hormone agonists during chemotherapy in cancer patients: From biological evidence to clinical application.

Cancer Treat Rev 2018 Dec 1;72:65-77. Epub 2018 Dec 1.

Fertility Clinic, CUB-Hôpital Erasme and Research Laboratory on Human Reproduction, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium.

Survivorship issues are an area of crucial importance to be addressed as early as possible by all health care providers dealing with cancer patients. In women diagnosed during their reproductive years, the possible occurrence of chemotherapy-induced premature ovarian insufficiency (POI) is of particular concern being associated with important menopause-related symptoms, psychosocial issues as well as infertility. Temporary ovarian suppression by administering a gonadotropin-releasing hormone agonist (GnRHa) during chemotherapy has been studied to reduce the gonadotoxic impact of chemotherapy thus diminishing the chance of developing POI. Read More

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December 2018

Long-term ovariectomy increases anxiety- and despair-like behaviors associated with lower Fos immunoreactivity in the lateral septal nucleus in rats.

Behav Brain Res 2018 Dec 7;360:185-195. Epub 2018 Dec 7.

Programa de Posgrado en Neuroetología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, Mexico; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, Mexico.

In woman, surgical menopause is associated with anxiety and depression symptoms. Ovariectomy in rats has been proposed as an experimental model of surgical menopause, but its long-term effects on anxiety- and depression-like behaviors and relationship with cellular changes in specific brain structures are unknown. The effects of ovariectomy on anxiety- and despair-like behavior 1, 3, 6, 9, 12, and 15-weeks postovariectomy were evaluated. Read More

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December 2018

The Relationship Between Breast Density, Bone Mineral Density, and Metabolic Syndrome Among Postmenopausal Turkish Women.

J Clin Densitom 2018 Nov 8. Epub 2018 Nov 8.

Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care Training and Research Hospital, Ankara, Turkey. Electronic address:

The relationship between metabolic syndrome (MetS) and menopause remains unclear. The effects of MetS on breast and bone density in this group of women are also not fully elucidated. Herein, we aimed to investigate the relationship between components of the MetS, mammographic breast density (MBD), and vertebral/femoral bone mineral density (BMD) in postmenopausal Turkish women. Read More

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November 2018

[Effects of menopausal factor on fine anatomy of bladder urethra and vagina in women undergoing vaginal delivery].

Zhonghua Yi Xue Za Zhi 2018 Dec;98(45):3676-3680

Department of Obstetrics and Gynecology, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China.

To explore the effects of menopausal factor on fine anatomy of bladder, urethra and vagina in women undergoing vaginal delivery. Gynecological patients in Nanfang hospital from January 2013 to October 2016 were collected, and then the patients whose MRI images quality meet the require of reconstruction, with the history of vaginal delivery experience, without any cesarean section experience, and the first labor time was ≤30 years old were enrolled. The patients who had pelvic floor dysfunction when done MRI examinations were excluded. Read More

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December 2018

Influence of Βeta-Cryptoxanthin Supplementation on Ovarian Reserve and Fertility Status in Aged Wistar Rats.

J Diet Suppl 2018 Dec 8:1-13. Epub 2018 Dec 8.

a School of Pharmacy and Medical Sciences, Division of Health Sciences , University of South Australia , Adelaide , Australia.

Previous observational studies have suggested that β-cryptoxanthin, a micronutrient present in yellow and orange fruit and vegetables, may help delay the onset of menopause. Given the widespread social trend of delaying pregnancy, the possibility that β-cryptoxanthin supplementation may delay age-related loss of fertility and onset of menopause is of significant interest. In a parallel study, either saline or β-cryptoxanthin (5 µg/kg rat/day) was delivered to Wistar albino rats via an osmotic pump from 4 to 7 months of age. Read More

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December 2018

Menopause-specific Quality of Life Questionnaire: factor and Rasch analytic approach.

Climacteric 2018 Dec 11:1-7. Epub 2018 Dec 11.

b Faculty of Medicine , University of Belgrade , Belgrade , Serbia.

Objective: The study aimed to assess the psychometric properties of the Menopause-specific Quality of Life Questionnaire (MENQOL) in Serbian climacteric women.

Methods: Two hundred mid-aged (40-65 years) women filled out a general sociodemographic and medical questionnaire, the MENQOL, the Short Form-36 questionnaire (SF-36), and Beck's Depression Inventory (BDI). The MENQOL was translated according to recommended methodology and its psychometric properties (internal consistency, discriminant, construct and criterion validity, factor and Rasch analyses) were assessed. Read More

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December 2018

Headache in Pregnancy, the Puerperium, and menopause.

Semin Neurol 2018 Dec 6;38(6):627-633. Epub 2018 Dec 6.

Department of Neurology, University at Buffalo School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York.

Headache is a neurologic disorder that displays gender dichotomy. It is well established that there is a strong link between migraine headache and sex hormones, specifically estrogen, which influences the severity of migraines during the menstrual cycle, pregnancy, and menopause. Furthermore, the epidemiology of headaches during pregnancy and the postpartum period is very distinct from that in males or nonpregnant females, in part due to the hemodynamic and hematologic changes that occur during pregnancy. Read More

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December 2018
3 Reads

The relationship between iron deficiency anemia and sexual function and satisfaction among reproductive-aged Iranian women.

PLoS One 2018 6;13(12):e0208485. Epub 2018 Dec 6.

Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Iron deficiency anemia (IDA) is a common micronutrient deficiency worldwide, and an important health problem especially in women of reproductive age. This study aimed to determine the relationship between IDA and sexual satisfaction and function among reproductive-aged Iranian women. In this study, 129 women (52 with IDA and 77 non-IDA) with age 18-45 in Mahshahr, Iran were recruited. Read More

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December 2018
5 Reads

Uterine Cancer Incidence and Mortality - United States, 1999-2016.

MMWR Morb Mortal Wkly Rep 2018 Dec 7;67(48):1333-1338. Epub 2018 Dec 7.

Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, CDC.

Uterine cancer is one of the few cancers with increasing incidence and mortality in the United States, reflecting, in part, increases in the prevalence of overweight and obesity since the 1980s (1). It is the fourth most common cancer diagnosed and the seventh most common cause of cancer death among U.S. Read More

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December 2018
5 Reads

[The Role of Testosterone in The Improvement of Sexual Desire in Postmenopausal Women: An Evidence-Based Clinical Review].

Acta Med Port 2018 Nov 30;31(11):680-690. Epub 2018 Nov 30.

Unidade de Saúde Familiar S. Julião. Agrupamento de Centros de Saúde de Lisboa Ocidental e Oeiras. Lisboa. Portugal.

Introduction: Female sexual dysfunction is a common problem, affecting more than 1/3 of women during their lives. The aim of this review is to review the evidence for the effectiveness of testosterone in sexual dysfunction in postmenopausal women, particularly in the improvement of sexual desire.

Material And Methods: The authors searched in international databases National Guidelines Clearinghouse, Guidelines Finder, Cochrane Library and MEDLINE/PubMed, for guidelines, systematic reviews, meta-analysis and randomized controlled trials, published between January 2005 and February 2017, using the MeSH terms 'testosterone', 'androgens', 'libido', 'sexual dysfunctions' and 'menopause'. Read More

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November 2018
5 Reads

The incidence and predictors of gynecologic malignancies among postmenopausal patients with endometrial fluid collection.

Authors:
Zhe Li Lei Li

Arch Gynecol Obstet 2018 Dec 5. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Shuaifuyuan No 1, Dongcheng District, Beijing, China.

Objective: To investigate the incidence and predictors of gynecologic malignancies among postmenopausal patients with endometrial fluid collection (EFC).

Methods: All patients with EFC diagnosed by transvaginal sonography (TVS) were retrospectively reviewed if they had undergone biopsy of the endometrium from January 2008 to January 2016 in a tertiary teaching hospital. Follow-up ended in June 2017. Read More

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December 2018
1 Read
1.279 Impact Factor

Women's Reproductive History and Pre-Clinical Peripheral Arterial Disease in Late Life: The San Diego Population Study.

J Womens Health (Larchmt) 2018 Dec 1. Epub 2018 Dec 1.

5 Premier Applied Sciences, Premier, Inc., Charlotte, North Carolina.

Objective: Reproductive events have been linked with increased cardiovascular risk in women, but whether they are associated with pre-clinical peripheral arterial disease (PAD) has been understudied. We evaluated associations between reproductive factors and later-life ankle-brachial index (ABI), femoral artery intima-media thickness (fIMT), and femoral plaques.

Methods: Cross-sectional analysis of 707 multiethnic women who participated in a follow-up exam of the San Diego Population Study in 2007-2011. Read More

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December 2018
1 Read

The route of administration, timing, duration and dose of postmenopausal hormone therapy and cardiovascular outcomes in women: a systematic review.

Hum Reprod Update 2018 Dec 1. Epub 2018 Dec 1.

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Background: The effect of postmenopausal hormone therapy (HT) on cardiovascular disease (CVD) risk remains controversial.

Objective And Rationale: We aimed to systematically review the evidence regarding the role of dose, route of hormone administration, timing of initiation and duration of HT on cardiovascular risk among postmenopausal women.

Search Methods: The electronic databases Medline Ovid, Web of Science and Cochrane Central were systematically searched to identify studies published before 30 January 2018. Read More

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December 2018
9 Reads

A case report of traditional Korean medicine treatments on uterine myoma with thyroid cancer.

Integr Med Res 2018 Dec 25;7(4):303-306. Epub 2018 Oct 25.

Department of Korean Medicine Obstetrics & Gynecology, College of Korean Medicine, Dae-jeon University, Daejeon, Republic of Korea.

Uterine myoma is a common benign tumor. When the symptoms are not severe, patients are often suggested to wait for menopause without treatment. If the size becomes too large or the symptoms get worse, the patient will receive surgery or hormone therapy. Read More

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December 2018
1 Read

Neurokinin 3 receptor antagonism - a novel treatment for menopausal hot flushes.

Neuroendocrinology 2018 Nov 30. Epub 2018 Nov 30.


Menopause is associated with significant symptomatic burden, with approximately two thirds of post menopausal women suffering from vasomotor symptoms, hot flushes and night sweats. The mainstay of treatment for hot flushes continues to be hormone replacement therapy. However, as HRT is contraindicated in some cases, alternative, efficacious treatment options are also required. Read More

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November 2018
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Does Transdermal Testosterone Increase the Risk of Developing Breast Cancer? A Systematic Review.

Anticancer Res 2018 Dec;38(12):6615-6620

London Breast Institute, London, U.K.

Background/aim: Hypoactive sexual desire disorder (HSDD) is hypothesised to manifest in postmenopausal women at onset of menopause due to decreased oestrogen levels. Transdermal testosterone is a potential treatment option. This systematic review explores the relationship between the incidence of breast cancer and transdermal testosterone use. Read More

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December 2018
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