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Horm Behav 2021 Jun 8;133:105005. Epub 2021 Jun 8.

Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan. Electronic address:

Oxytocin (OT) and its receptor (OTR) play various roles in the central and peripheral regulation of appetite and body weight. Previously, we have shown that the administration of OT markedly decreased appetite and body weight gain in ovariectomized (OVX) obese rats. In addition, recent studies have shown that the endogenous OT system is also affected by endogenous or exogenous estrogen. Read More

Neurosci Lett 2021 Jun 8:136038. Epub 2021 Jun 8.

Department of Applied Neuroscience and Neuroimaging (RA) and Department of Experimental Neuroscience (SVO), National Institute of Mental Health, Topolová 748, 250 67, Klecany, Czech Republic.

Although produced largely in the periphery, gonadal steroids play a key role in regulating the development and functions of the central nervous system and have been implicated in several chronic neuropsychiatric disorders, with schizophrenia and Alzheimer's disease (AD) most prominent. Despite major differences in pathobiology and clinical manifestations, in both conditions, estrogen transpires primarily with protective effects, buffering the onset and progression of diseases at various levels. As a result, estrogen replacement therapy (ERT) emerges as one of the most widely discussed adjuvant interventions. Read More

Curr Pharm Des 2021 Jun 10. Epub 2021 Jun 10.

University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Medical Faculty, University of Skopje, Skopje, Macedonia.

Metabolic syndrome (MetS) represents a cluster of metabolic disorders that arise from insulin resistance (IR) and adipose tissue dysfunction. As a consequence, there is an increased risk for type 2 diabetes mellitus and atherosclerotic cardiovascular disease (CVD). MetS is associated with a 2-fold increase in cardiovascular outcomes. Read More

Front Oncol 2021 25;11:658358. Epub 2021 May 25.

Department of Radiation Oncology, CyberKnife and Radiation Therapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Introduction: Consolidation radiotherapy in intermediate stage Hodgkin´s lymphoma (HL) has been the standard of care for many years as involved field radiotherapy (IFRT) after chemotherapy. It included initially involved region(s). Based on randomized studies, radiation volumes could be reduced and involved site radiation therapy (ISRT) became the new standard. Read More

Maturitas 2021 May 30. Epub 2021 May 30.

School of Public Health and Preventive Medicine, Monash University, Level 4/553St Kilda Road, Melbourne, VIC 3004, Australia. Electronic address:

This systematic review summarises the available evidence about how migrant women perceive and manage their menopausal and postmenopausal health and their experiences with healthcare services; and healthcare providers' views about delivering menopause-related healthcare to migrant women. Medline, PsychInfo, Embase and Cinahl were searched for peer-reviewed papers published in English. Thirty-one papers were identified reporting on 25 studies. Read More

Rev Esp Geriatr Gerontol 2021 Jun 7. Epub 2021 Jun 7.

Laboratorio de Diseño Molecular, Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, México. Electronic address:

The use of 17 β-estradiol and genistein in women with menopause helps in the reduction of vasomotor symptoms and cognitive improvement. There is evidence on the use of certain flavonoids such as genistein, which has a potentially neuroprotective role in neurodegenerative diseases such as Alzheimer's. Scientific evidence on the effects of phytoestrogens and genistein during menopause and their effect on cognition are scarce, however, in the present review it was found that the intervention with 17 β-estradiol has positive effects on cognition in women with Alzheimer's disease. Read More

Am J Obstet Gynecol 2021 Jun 7. Epub 2021 Jun 7.

Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina USA; Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina, USA. Electronic address:

Background: Bilateral oophorectomy before menopause, or surgical menopause, is associated with negative health outcomes, including increased risk of stroke and other cardiovascular outcomes; however, surgical menopause also dramatically reduces ovarian cancer incidence and mortality rates. Because there are competing positive and negative sequelae of surgical menopause, clinical guidelines have not been definitive. Previous research indicates that White women have higher rates of surgical menopause than other groups. Read More

Arch Physiol Biochem 2021 Jun 10:1-6. Epub 2021 Jun 10.

Université Clermont Auvergne, CRNH, AME2P, Clermont-Ferrand, France.

Context: Independently of the total body fat mass, upper body fat mass deposition is strongly associated with cardiometabolic comorbidities. The mechanisms underlying fat mass localisation are not fully understood, but evidences indicate sex-specific fat mass distribution. Currently, data on women are scarce and the link between hormonal status changes during their life and fat mass distribution is overlooked. Read More

Eur Rev Med Pharmacol Sci 2021 May;25(10):3859-3867

Department of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University in Szczecin, Szczecin, Poland.

Objective: The results of pioneering studies indicate that probiotics can alleviate menopausal symptoms (including cardiometabolic dysfunctions) and improve the quality of life of perimenopausal/postmenopausal women. However, the results of randomized control trials are scarce to evaluate whether the administration of probiotics could affect the balance of sex hormones during the menopause period.

Patients And Methods: In this randomized, double-blind, and placebo-controlled study, 48 perimenopausal and postmenopausal women received multispecies probiotic Sanprobi Barrier in a dose of 2. Read More

Front Endocrinol (Lausanne) 2021 24;12:691432. Epub 2021 May 24.

Discipline of Obstetrics & Gynaecology, School of Women's & Children's Health, University of New South Wales, Sydney, NSW, Australia.

Serum anti-Mullerian hormone (AMH) is a widely used marker of functional ovarian reserve in the assessment and treatment of infertility. It is used to determine dosing of gonadotropins used for superovulation prior to fertilization, as well as to determine the degree of damage to ovarian reserve by cytotoxic treatments such as chemotherapy. AMH is also now used to predict proximity to menopause and potentially provides a sensitive and specific test for polycystic ovarian syndrome. Read More

Sci Rep 2021 Jun 9;11(1):10867. Epub 2021 Jun 9.

Departments of Pharmacology and Neurology, College of Medicine, University of Arizona, Tucson, AZ, USA.

All women undergo the menopause transition (MT), a neuro-endocrinological process that impacts aging trajectories of multiple organ systems including brain. The MT occurs over time and is characterized by clinically defined stages with specific neurological symptoms. Yet, little is known of how this process impacts the human brain. Read More

Maturitas 2021 May 24. Epub 2021 May 24.

Physiotherapy and Sports Rehabilitation Research Group, Catholic University of Murcia.| San Antonio Catholic University of Murcia: Universidad Catolica San Antonio de Murcia.

The prevalence of hypertension is higher in postmenopausal than in premenopausal women. Regular exercise training has been shown to be effective in addressing hypertension. The aim of this systematic review was to synthesize the effect of exercise training on systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) in menopausal and postmenopausal women. Read More

Phytomedicine 2021 May 26;88:153605. Epub 2021 May 26.

Shenzhen Key Laboratory of Edible and Medicinal Bioresources, Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen, 518000, China; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.

Osteoporosis is the process of bone loss, particular after menopause, when the production of estrogen in women is decreaing. Bioenergetic function is one of the critical roles in bone remodeling. Danggui Buxue Tang (DBT) is an herbal mixture containing Astragali Radix (AR) and Angelicae Sinensis Radix (ASR), and which is consumed for "Qi-invigorating", i. Read More

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Department of Gynecological Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Premature ovarian insufficiency (POI) is one of the vital reasons of anovulatory infertility among women under 40 years old. However, because of the unacknowledged causative factor in most cases, it still remains a huge challenge in gynecology. Recently, the most promising opportunities in diagnosing are connected with the use of some serum biomarkers, such as interleukin-17 (IL-17), Frizzled-5 protein, Soggy-1 protein and other cytokines. Read More

Nutr Rev 2021 Jun;79(7):758-776

Department of Public Health and Primary Care, Ghent University, Ghent, Belgium.

Context: Apart from ruminant fat, trans-fatty acids are produced during the partial hydrogenation of vegetable oils, (eg, in the production of ultraprocessed foods). Harmful cardiovascular effects of trans-fatty acids are already proven, but the link with cancer risk has not yet been summarized.

Objective: A systematic review (following PRISMA guidelines) - including observational studies on the association of trans-fatty acid intake with any cancer risk - was conducted, with no limitations on population types. Read More

Ther Adv Endocrinol Metab 2021 30;12:20420188211013917. Epub 2021 Apr 30.

Department of Medicine, Emory University, 137 Johnson Ferry Rd, Suite 1200, Marietta, GA 30068, USA.

Women are at increased risk for cardiovascular disease (CVD) compared with men. While traditional risk factors for CVD seem to disproportionately affect women and contribute to this disparity, increased prevalence of CVD at midlife calls into question the contribution of menopause. Given the potential role that declining hormone levels play in this transition, menopause hormone therapies (MHT) have been proposed as a strategy for risk factor reduction. Read More

J Clin Med Res 2021 May 25;13(5):309-316. Epub 2021 May 25.

Office of Medical Education, School of Medicine, International University of Health and Welfare, 4-3, Kozunomori, Narita-shi, Chiba 286-8686, Japan.

Background: Selective sodium-glucose cotransporter 2 inhibitors, known to lower the blood glucose levels by promoting the urinary glucose excretion, can predispose to genitourinary infections. This prospective study investigated the influence of selective sodium-glucose cotransporter 2 inhibitors luseogliflozin on the vaginal flora of the pre- and postmenopausal women with type 2 diabetes mellitus.

Methods: Twelve premenopausal and 24 postmenopausal female Japanese patients with type 2 diabetes mellitus took luseogliflozin 2. Read More

Am J Pathol 2021 Jun 5. Epub 2021 Jun 5.

Thrombosis and Atherosclerosis Research Institute, , McMaster University, Hamilton, Ontario, Canada, 237 Barton Street East Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada, 237 Barton Street East Hamilton, Ontario, Canada. Electronic address:

Insulin resistance results when peripheral tissues, including adipose, skeletal muscle and liver, do not respond appropriately to insulin causing the ineffective uptake of glucose. This represents a risk factor for the development of type 2 diabetes mellitus. Along with abdominal obesity, hypertension, high levels of triglycerides, and low levels of high-density lipoproteins, insulin resistance is a component of a condition known as the metabolic syndrome, which significantly increases the risk of developing cardiometabolic disorders. Read More

J Bone Miner Res 2021 Jun 8. Epub 2021 Jun 8.

R&D and Innovation Department, Faes Farma, Leioa, Spain.

Vitamin D has shown to play a role in multiple diseases due to its skeletal and extraskeletal actions. Furthermore, vitamin D deficiency has become a worldwide health issue. Few supplementation guidelines mention calcifediol treatment, despite being the direct precursor of calcitriol and the biomarker of vitamin D status. Read More

J Natl Cancer Inst 2021 Jun 8. Epub 2021 Jun 8.

Division of Molecular Pathology, Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

Background: Benefit of adjuvant aromatase inhibitors (AI) versus tamoxifen has been investigated in randomized clinical trials for premenopausal and postmenopausal patients with early, estrogen receptor positive (ER+) breast cancer. The optimal endocrine treatment for chemotherapy-treated perimenopausal women, who generally develop chemotherapy-induced amenorrhea, is uncertain.

Methods: All Dutch women who received adjuvant chemotherapy and endocrine treatment for stage I-III, ER + (>10% positive cells), invasive breast cancer, diagnosed between 2004-2007, were identified through the Netherlands Cancer Registry. Read More

Post Reprod Health 2021 Jun 7:20533691211014741. Epub 2021 Jun 7.

Green City Hospital, Kathmandu, Nepal.

Background: Menopause is one of the natural phenomena in every woman's life. The transition phase gradually brings lots of changes in the life of women, both physically and mentally. In Nepal, these changes are often viewed as the symptoms of old age. Read More

Cancer Epidemiol 2021 Jun 4;73:101964. Epub 2021 Jun 4.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China. Electronic address:

Background: Thyroid cancer (TC) is threefold more common in women than men. Reproductive and menstrual factors may be related to the onset of papillary thyroid cancer (PTC). This study aims to determine the association of reproductive and menstrual factors with PTC in Chinese females. Read More

Exp Gerontol 2021 Jun 8;152:111436. Epub 2021 Jun 8.

Public Health School, University of São Paulo, Brazil; School of Arts, Science and Humanities, University of São Paulo, Brazil. Electronic address:

Objectives: To investigate the association between joint diseases (JD) and common mental disorders (CMD) in women at ages related to menopause.

Study Design: Cross-sectional, population-based study (São Paulo City Health Survey, SP, Brazil). The sample was composed of 1191 women, 40 years and older. Read More

Minerva Obstet Gynecol 2021 Jun 7. Epub 2021 Jun 7.

Fidia Farmaceutici, S.p.A., Abano Terme, Padua, Italy.

Background: The study aimed to assess the performance and safety of single-use applicators prefilled with hyaluronic acid (HA)-based vaginal gel (Hyalo Gyn) for the treatment of vulvovaginal atrophy (VVA)-related signs and symptoms in postmenopausal women.

Methods: Eighty women were randomized, 46 to Hyalo Gyn gel and 34 to a standard treatment (water-based lubricant). Outcome data collected included: the proportion of subjects having a reduction ≥1 point in the Verbal Rating Scale (VRS) dryness score, VRS global score, vaginal pH, Vaginal Health Index (VHI), Female Sexual Function Index (FSFI), Female Sexual Distress Scale-Revised (FSDS-R), patients' global assessment, tolerability, and safety. Read More

Chronobiol Int 2021 Jun 5:1-6. Epub 2021 Jun 5.

Department of Epidemiology and Biostatistics, Menopause & Andropause Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Hypertension is a major risk factor for developing cardiovascular disease. Various factors such as occupational and environmental risk factors affect blood pressure. Shift work is considered to be an occupational stressor. Read More

Brain Inj 2021 Jun 6:1-9. Epub 2021 Jun 6.

Rehabilitation Sciences Building, 500 University Ave, Toronto, Ontario, Canada.

: Primary: To explore anti-Müllerian Hormone (AMH) levels in community dwelling women following TBI. Secondary: To explore the relation of AMH to menstrual cycle, cognition, distress and symptoms of menopause. Large adult TBI outpatient clinic in Toronto Canada. Read More

Curr Opin Endocr Metab Res 2021 Jun 8;18:165-170. Epub 2021 Apr 8.

UCLA David Geffen School of Medicine, Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience & Human Behavior, Cousins Center for Psychoneuroimmunology.

Sleep disturbances and insomnia are common among breast cancer survivors, and can have a significant effect on quality of life and numerous other significant outcomes. Among risks for sleep disturbance is the introduction of anti-estrogen endocrine therapies. The possible contributing factors to sleep disturbance in endocrine therapy are complex, and include pre-existing sleep disorders, the effects of chemotherapy and other treatments, and concurrent symptoms such as hot flashes. Read More

AACE Clin Case Rep 2021 Mar-Apr;7(2):145-148. Epub 2020 Dec 28.

Endocrinology Unit, División of Pediatric, Pontificia Universidad Católica, Santiago, Chile.

Objective: During the prenatal period, steroidogenic factor 1 is required for the development of the adrenal glands and for gonadal determination and differentiation, and after birth, it regulates gonadal progenitor cell formation and their survival. Here, we describe the clinical phenotype of three 46,XY patients (2 brothers and an unrelated subject) with disorder of sex development due to the same genetic variant.

Methods: All patients underwent hormonal and pelvic ultrasound studies. Read More

Bone Rep 2021 Jun 18;14:101094. Epub 2021 May 18.

Penn State University, University Park, PA, USA.

The use of non-pharmacological alternatives to pharmacological interventions, e.g., nutritional therapy, to improve or maintain bone mineral density (BMD) in postmenopausal women has gained traction over the past decade, but limited data exist regarding its efficacy. Read More

Front Endocrinol (Lausanne) 2021 19;12:682012. Epub 2021 May 19.

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

During aging and menopausal transition in women, a progressive muscle degeneration ( decrease in quality and muscle function) occurs. This muscle dysfunction, caused by decreased proliferation of muscle satellite cells, increased levels of inflammatory markers, and altered levels of sex hormones, exposes women to a raised incidence of sarcopenia. In this regard, hormonal balance and, in particular, estradiol, seems to be essential in skeletal muscle function. Read More