66,645 results match your criteria Menopause


Intravaginal treatment with Marantodes Pumilum (Kacip Fatimah) ameliorates vaginal atrophy in rats with post-menopausal condition.

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address:

Ethnopharmacological Relevance: Marantodes pumilum (MP) (Kacip Fatimah) is used to maintain the well-being of post-menopausal women. However, its role in ameliorating post menopause-related vaginal atrophy (VA) is unknown.

Aims: To investigate the ability of intravaginal MP gel treatment to ameliorate VA in sex-steroid deficient condition, mimicking post-menopause. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.027DOI Listing
February 2019

Prevalence of Low Bone Density and Comorbid Hypogonadism in Patients With Chronic Pancreatitis.

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

From the Division of Endocrinology, Department of Internal Medicine.

Objectives: Patients with chronic pancreatitis (CP) are at increased risk of low bone mineral density (BMD), although the prevalence of low BMD in patients with CP in the United States is lacking. We aimed to determine the prevalence of low BMD and identify potential risk factors, including hypogonadism and use of opioid medications, in subjects with CP in the United States.

Methods: This was a prospective, observational study. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001257DOI Listing
February 2019

Early menarche and premature natural menopause in Indonesia.

Ann Hum Biol 2018 Aug;45(5):419-427

b Portsmouth Brawijaya Centre for Global Health, Population and Policy , University of Brawijaya , Malang , Indonesia.

Background: An association has been suggested between early menarche and premature natural menopause. However, existing studies in developed countries show mixed findings.

Aim: This study examined whether early menarche (first menstrual period ≤11 years old) is a factor for premature natural menopause (final menstrual period <40 years old) in the context of a developing country. Read More

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http://dx.doi.org/10.1080/03014460.2018.1523461DOI Listing

Do psychosocial variables mediate the relationship between menopause symptoms and sexual function in middle-aged perimenopausal women?

J Obstet Gynaecol Res 2019 Feb 14. Epub 2019 Feb 14.

College of Nursing, Chonbuk Research Institute of Nursing Science, Chonbuk National University, Jeonju, South Korea.

Aim: To test a hypothetical path model evaluating the influence of menopause symptoms on sexual function among middle-aged perimenopausal women, as well as identify the mediating roles of body image, depression and sexual communication in this relationship.

Methods: We used a cross-sectional, correlational design. We included one exogenous variable (menopause symptoms) and four endogenous variables (body image, depression, sexual communication and sexual function) in the proposed model. Read More

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http://dx.doi.org/10.1111/jog.13927DOI Listing
February 2019

Genital Infections with Sodium Glucose Cotransporter-2 Inhibitors: Occurrence and Management in Patients with Type 2 Diabetes Mellitus.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):837-842

Medical Affairs, AstraZeneca Pharma India Ltd., Bengaluru, Karnataka, India.

Diabetes is a metabolic disorder characterized by hyperglycemia and is associated with several comorbidities and complications. Genital infection is one such complication that is often associated with diabetes mellitus (DM). Even though abnormalities in immune system, high urine glucose, and bladder dysfunction are important contributors for the increased risk of genitourinary symptoms, yet the possible role of pharmacologically induced glucosuria cannot be completely overlooked in such patients. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_159_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330876PMC
February 2019

Neighborhood disorder, exposure to violence, and perceived discrimination in relation to symptoms in midlife women.

Womens Midlife Health 2018 19;4:14. Epub 2018 Oct 19.

3Department of Anthropology, UMass Amherst, Amherst, MA USA.

Background: Some symptoms at midlife are associated with stress, such as hot flashes, trouble sleeping, headaches, or depressed mood. Hot flashes have been studied in relation to laboratory stressors, physiological biomarkers, and self-reported stress, but less is known about hot flashes in relation to the larger context of women's lives. This study examined the risk of symptoms in relation to neighborhood disorder, exposure to neighborhood violence, social cohesion and perceived discrimination. Read More

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http://dx.doi.org/10.1186/s40695-018-0043-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297945PMC
October 2018

Contraceptive challenges and the transgender individual.

Womens Midlife Health 2018 13;4:12. Epub 2018 Jul 13.

Clinical Instructor and Academic Faculty Scholar, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, 125 Paterson St, New Brunswick, NJ 08901 USA.

In recent years public awareness of healthcare disparities experienced by transgender individuals throughout the world have garnered increasing attention within the media and from health advocates. Despite this increasing awareness, a paucity of research data and clinical protocols of care for clinicians continues to exist, especially in regard to the transgender individual's family planning needs. Clinicians should be on the forefront of promoting strategies that forge a meaningful and collaborative relationship with the transgender man, including as he transitions through to the menopause and his sexual and reproductive healthcare needs. Read More

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http://dx.doi.org/10.1186/s40695-018-0042-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297942PMC

Stress and the menopausal transition in Campeche, Mexico.

Womens Midlife Health 2018 18;4. Epub 2018 Jun 18.

4Department of Anthropology, University of Hawai'i at Hilo, Hilo, HI USA.

Background: Stress has been implicated as a factor in the presence and severity of symptoms during the menopausal transition. Our primary aim was to test the hypothesis that stress-sensitive biological measures and self-reported stress would be positively associated with a greater likelihood and intensity of hot flashes. Our secondary aim was to examine measures of stress in relation to the most often reported symptoms in Campeche, Mexico. Read More

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http://dx.doi.org/10.1186/s40695-018-0038-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298015PMC

The challenges of midlife women: themes from the Seattle midlife Women's health study.

Womens Midlife Health 2018 15;4. Epub 2018 Jun 15.

3Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, Wahsington USA.

Background: Midlife, the period of the lifespan between younger and older adulthood, has been described as a period of transition in women's lives. Investigators studying midlife have focused on women 40 to 65 years of age, who typically experience multiple social, psychological and biological challenges, among them the menopausal transition. Investigators have reported a diverse array of stressful events, for example, health concerns, family problems, work-related issues, deaths, frustrated goal attainment, and financial worries; however, none have identified which life events midlife women experience as the most salient. Read More

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http://dx.doi.org/10.1186/s40695-018-0039-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298022PMC

Prophylactic salpingo-oophorectomy & surgical menopause for inherited risks of cancer: the need to identify biomarkers to assess the theoretical risk of premature coronary artery disease.

Womens Midlife Health 2018 27;4. Epub 2018 Apr 27.

1Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Health Research Innovation Centre, GB42, 3280 Hospital Dr NW, Calgary, AB T2N 4Z6 Canada.

Background: Some women with genetic risk of breast and/or ovarian cancer (e.g., BRCA1/2) opt to undergo prophylactic salpingo-oophorectomy (PSO, or surgical removal of the ovaries & fallopian tubes) in order to reduce their risk of cancer. Read More

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http://dx.doi.org/10.1186/s40695-018-0037-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297996PMC

Bone mineral density in midlife long-term users of hormonal contraception in South Africa: relationship with obesity and menopausal status.

Womens Midlife Health 2018 10;4. Epub 2018 Apr 10.

1MatCH Research Unit [Maternal, Adolescent and Child Health Research Unit], Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University of the Witwatersrand, 40 Dr AB Xuma Street,11th floor, Suite 1108-9,Commercial City, Durban, 4001 South Africa.

Background: In South Africa, hormonal contraception is widely used in women over the age of 40 years. One of these methods and the most commonly used is depot-medroxyprogesterone acetate (DMPA) which has been found to have a negative effect on bone mass. Limited information is available on the effect of norethisterone enanthate (NET-EN) on bone mass, and combined oral contraceptives (COCs) have not been found to be associated with loss of bone mass. Read More

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http://dx.doi.org/10.1186/s40695-018-0035-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297953PMC

Is in utero exposure to maternal socioeconomic disadvantage related to offspring ovarian reserve in adulthood?

Womens Midlife Health 2018 16;4. Epub 2018 Mar 16.

6Department of Obstetrics, Gynecology, & Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143 USA.

Background: Because the ovarian follicle pool is established in utero, adverse exposures during this period may be especially impactful on the size and health of the initial follicle endowment, potentially shaping trajectories of ovarian follicle loss and the eventual onset of menopause. Building on a robust literature linking socioeconomic status (SES) and menopausal timing, the current study examined adverse prenatal exposures related to maternal SES, hypothesizing that greater maternal socioeconomic disadvantage would be associated with lower ovarian reserve in the adult offspring.

Methods: In a healthy, community-based sub-sample ( = 350) of reproductive age participants in the OVA Study (2006-2011), prenatal maternal SES was examined in relation to two biomarkers of ovarian reserve, antimullerian hormone (AMH) and antral follicle count (AFC). Read More

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http://dx.doi.org/10.1186/s40695-018-0033-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297989PMC

Work outcomes in midlife women: the impact of menopause, work stress and working environment.

Womens Midlife Health 2018 9;4. Epub 2018 Apr 9.

1Department Psychology (at Guy's), Institute of Psychiatry, Psychology and Neuroscience, Kings College London, 5th Floor Bermondsey Wing, Guy's Campus, London, SE1 9RT UK.

Background: There is growing research interest in the question of whether menopause impacts upon mid-aged women's work outcomes, but the evidence to date is inconclusive. This paper examines whether: (i) menopausal status, and experience of hot flushes and night sweats (HFNS), and whether (ii) work stress and work environment, are associated with work outcomes (absenteeism, job performance, turnover intention, and intention to leave the labor force).

Methods: An online survey (sociodemographic, menopause, health, well-being and aspects of work) was completed by 216 (pre-, peri- and postmenopausal) women aged 45-60 years. Read More

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http://dx.doi.org/10.1186/s40695-018-0036-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298001PMC

The role of smoking in the relationship between intimate partner violence and age at natural menopause: a mediation analysis.

Womens Midlife Health 2018 15;4. Epub 2018 Jan 15.

2Research Centre for Generational Health and Ageing, The University of Newcastle, Callaghan, NSW Australia.

Background: Age at natural menopause (ANM) is considered as a biologic marker of health and ageing. The relationship between intimate partner violence (IPV) and ANM is currently unknown, and whether smoking plays a role in this relationship is unclear. The aim of this study was to examine the association between IPV and ANM and to quantify the effect mediated through smoking. Read More

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http://dx.doi.org/10.1186/s40695-017-0031-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297990PMC
January 2018

Genitourinary syndrome of menopause treatment using lasers and temperature-controlled radiofrequency.

Prz Menopauzalny 2018 Dec 31;17(4):180-184. Epub 2018 Dec 31.

3 Chair and Department of Gynaecology, Medical University of Lublin, Lublin, Poland.

Perimenopausal changes caused by oestrogen deficiency are accompanied by a decrease in the content of collagen and elastin in the tissues, leading to thinning of the epithelium and the resultant disappearance of the superficial layer, which leads to smooth muscle dysfunction as well as connective tissue degradation. This aetiopathogenetic chain results in a set of symptoms experienced by approximately 50% of women in the peri- and postmenopausal period. Symptoms of dryness, burning, dyspareunia and urgency contribute to a significant reduction in the quality of sexual function and general comfort of life due to recurrent infections of the vagina, vulva and urinary tract. Read More

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http://dx.doi.org/10.5114/pm.2018.81743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372847PMC
December 2018

Selected vitamins and quality of life in menopausal women.

Prz Menopauzalny 2018 Dec 31;17(4):175-179. Epub 2018 Dec 31.

3 Chair and Department of Gynaecology, Medical University of Lublin, Lublin, Poland.

The article presents the results of the latest studies on the correlation between the levels of selected vitamins, their bio-availability and their influence on bodily tissues and the quality of life in menopausal women. It also discusses the correlations between vitamin concentrations and the incidence of diseases characteristic of the transitional period, which affects the quality of life. Read More

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http://dx.doi.org/10.5114/pm.2018.81742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372850PMC
December 2018

Genitourinary syndrome of menopause - is the problem solved? State of the art 2018.

Prz Menopauzalny 2018 Dec 31;17(4):168-174. Epub 2018 Dec 31.

1 Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, Warsaw, Poland.

Vulvovaginal atrophy accompanied by lower urinary tract dysfunction related to low levels of estrogen and androgens is labeled as genitourinary syndrome of menopause (GSM). Although this condition affects most postmenopausal women worldwide, it seems to be underdiagnosed and undertreated. Women should be properly advised to choose an adequate treatment modality to improve their quality of life, sexual relationships and social activity. Read More

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http://dx.doi.org/10.5114/pm.2018.81741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372854PMC
December 2018

Effects of six weeks of resistance-endurance training on microRNA-29 expression in the heart of ovariectomised rats.

Prz Menopauzalny 2018 Dec 30;17(4):155-160. Epub 2018 Dec 30.

Nutrition and Physical Activity Laboratory, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile.

Introduction: Heart disease risk rises with age. However, women's symptoms become more pronounced following the onset of menopause. The aim of the present study was to evaluate the effects of six weeks of combined resistance-endurance (RE) training on microRNA-29 expression in the heart of ovariectomised rats. Read More

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http://dx.doi.org/10.5114/pm.2018.81737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372852PMC
December 2018

Diagnostic value of histopathological examination results obtained during screening of patients with diagnosed atypical hyperplasia.

Prz Menopauzalny 2018 Dec 31;17(4):144-148. Epub 2018 Dec 31.

Department of Operative Gynecology, Endoscopy and Gynecologic Oncology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.

Vulvovaginal atrophy accompanied by lower urinary tract dysfunction related to low levels of estrogen and androgens is labeled as genitourinary syndrome of menopause (GSM). Although this condition affects most postmenopausal women worldwide, it seems to be underdiagnosed and undertreated. Women should be properly advised to choose an adequate treatment modality to improve their quality of life, sexual relationships and social activity. Read More

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http://dx.doi.org/10.5114/pm.2018.81734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372849PMC
December 2018

Effects of aging and menopause on pancreatic fat fraction in healthy women population: A strobe-compliant article.

Medicine (Baltimore) 2019 Feb;98(7):e14451

Department of Gastroenterology.

Pancreatic fat fraction has been shown to increase in many pathological situations. However, pancreatic fat fraction and its physiological changes in healthy women are still unclear. The aim of this study is to investigate the effect of aging and menopause on pancreatic fat fraction in healthy female population. Read More

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http://dx.doi.org/10.1097/MD.0000000000014451DOI Listing
February 2019

DDT and Breast Cancer: Prospective Study of Induction Time and Susceptibility Windows.

J Natl Cancer Inst 2019 Feb 13. Epub 2019 Feb 13.

Background: In a previous Child Health and Development Studies report, p, p'-DDT was associated with a fivefold increased risk of premenopausal (before age 50 years) breast cancer for women first exposed before puberty. Here we extend our observation to breast cancer diagnosed during early postmenopause (ages 50-54 years) to determine whether age at diagnosis modifies the interaction of DDT with age at exposure.

Methods: We conducted a second prospective, nested case-control study in the Child Health and Development Studies (153 incident breast cancer cases diagnosed at ages 50-54 years and 432 controls matched to cases on birth year). Read More

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http://dx.doi.org/10.1093/jnci/djy198DOI Listing
February 2019

Depression during perimenopause: the role of the obstetrician-gynecologist.

Arch Womens Ment Health 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, University of Washington School of Medicine, 1959 NE Pacific St., Box 356460, Seattle, WA, 98195-6460, USA.

Depression in women is more common during perimenopause (the transition to menopause) than at other times in the life cycle. Symptoms of depression may be different in perimenopausal women compared to younger or older women, and are often dismissed as part of normal menopause. This is an expert narrative review. Read More

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http://link.springer.com/10.1007/s00737-019-0950-6
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http://dx.doi.org/10.1007/s00737-019-0950-6DOI Listing
February 2019
2 Reads

Antiresorptive and anabolic agents in the prevention and reversal of bone fragility.

Nat Rev Rheumatol 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine and St Vincent's Institute, University of Melbourne, Melbourne, Victoria, Australia.

Bone volume, microstructure and its material composition are maintained by bone remodelling, a cellular activity carried out by bone multicellular units (BMUs). BMUs are focally transient teams of osteoclasts and osteoblasts that respectively resorb a volume of old bone and then deposit an equal volume of new bone at the same location. Around the time of menopause, bone remodelling becomes unbalanced and rapid, and an increased number of BMUs deposit less bone than they resorb, resulting in bone loss, a reduction in bone volume and microstructural deterioration. Read More

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http://dx.doi.org/10.1038/s41584-019-0172-3DOI Listing
February 2019

Role of sex in post-transplant diabetes mellitus development: Are men and women equal?

J Diabetes Complications 2019 Jan 4. Epub 2019 Jan 4.

Ist Department of Internal Diseases, University Hospital Martin and Jessenius Medical Faculty of Comenius University, Slovak Republic.

Introduction: Sex differences are defined as biology-linked differences between women and men that occur through the sex chromosomes and their effects on organ systems.

Material And Methods: The objective of this prospective study was to determine risk factors for post-transplant diabetes mellitus (PTDM) in men and women.

Results: A total of 417 patients (271 men and 146 women) were included in the monitored group. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.017DOI Listing
January 2019

Rotating night shift work and menopausal age.

Hum Reprod 2019 Feb 12. Epub 2019 Feb 12.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Study Question: How are rotating night shift schedules associated with age at menopause among a large, national cohort of shift working nurses?

Summary Answer: Our findings suggest that working rotating night shifts with sufficient frequency may modestly accelerate reproductive senescence among women who may already be predisposed to earlier menopause.

What Is Known Already: Younger age at menopause has been associated with increased risk of adverse health outcomes, particularly those linked to reproduction. Night work has been associated with reproductive dysfunction, including disruption of menstrual cycle patterns. Read More

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http://dx.doi.org/10.1093/humrep/dey390DOI Listing
February 2019
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Hormone replacement therapy: changes in prescribing practice.

BMJ 2019 Feb 11;364:l633. Epub 2019 Feb 11.

British Menopause Society Medical Advisory Council, British Menopause Society, Spracklen House, Marlow SL7 2QH, UK.

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http://dx.doi.org/10.1136/bmj.l633DOI Listing
February 2019
1 Read

Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism.

Curr Biol 2019 Jan 29. Epub 2019 Jan 29.

Department of Biology, University of Washington, Seattle, WA 98195, USA. Electronic address:

Successful reproduction in female mammals is precisely timed and must be able to withstand the metabolic demand of pregnancy and lactation. We show that kisspeptin-expressing neurons in the arcuate hypothalamus (Kiss1) of female mice control the daily timing of food intake, along with the circadian regulation of locomotor activity, sleep, and core body temperature. Toxin-induced silencing of Kiss1 neurons shifts wakefulness and food consumption to the light phase and induces weight gain. Read More

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http://dx.doi.org/10.1016/j.cub.2019.01.022DOI Listing
January 2019

Limits to Fitness Benefits of Prolonged Post-reproductive Lifespan in Women.

Curr Biol 2019 Jan 29. Epub 2019 Jan 29.

Department of Biology, University of Turku, 20014 Turku, Finland.

Recent advances in medicine and life-expectancy gains have fueled multidisciplinary research into the limits of human lifespan [1-3]. Ultimately, how long humans can live for may depend on selection favoring extended longevity in our evolutionary past [4]. Human females have an unusually extended post-reproductive lifespan, which has been explained by the fitness benefits provided from helping to raise grandchildren following menopause [5, 6]. Read More

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http://dx.doi.org/10.1016/j.cub.2018.12.052DOI Listing
January 2019
1 Read

The relationship between menopausal symptoms and metabolic syndrome in postmenopausal women.

J Obstet Gynaecol 2019 Feb 11:1-5. Epub 2019 Feb 11.

a Department of Obstetrics and Gynecology , University of Health Sciences Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital , Istanbul , Turkey.

The most common symptoms during menopausal transition and menopause are vasomotor symptoms. We aimed to investigate the relationship between menopausal symptoms and metabolic syndrome (MetS) in postmenopausal women. Two hundred and fifty-four and 317 postmenopausal women were in the MetS and non-MetS groups, respectively. Read More

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http://dx.doi.org/10.1080/01443615.2018.1534812DOI Listing
February 2019
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The clinical role of LASER for vulvar and vaginal treatments in gynecology and female urology: An ICS/ISSVD best practice consensus document.

Neurourol Urodyn 2019 Feb 11. Epub 2019 Feb 11.

Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa.

Background: The clinical role of LASER for vulvar and vaginal treatments in gynecology and female urology is controversial.

Aims: In this best practice document, we propose recommendations for the use of LASER for gynecologic and urologic conditions such as vulvovaginal atrophy, urinary incontinence, vulvodynia, and lichen sclerosus based on a thorough literature review.

Materials & Methods: This project was developed between January and September 2018. Read More

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http://doi.wiley.com/10.1002/nau.23931
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http://dx.doi.org/10.1002/nau.23931DOI Listing
February 2019
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Prospective observational study to evaluate the efficacy and safety of the pollen extract Sérélys in the management of women with menopausal symptoms.

Gynecol Endocrinol 2019 Feb 10:1-4. Epub 2019 Feb 10.

b Exeltis Healthcare , Ismaning , Germany.

Safety concerns or contraindications to the use of hormones have resulted in a rise of the use of herbal medicinal products for the management of menopausal symptoms. The pollen extract Sérélys represents, due to its ingredients and mode of action, a new and innovative alternative for the management of these symptoms. The aim of the present study was to demonstrate the efficacy and safety of Sérélys. Read More

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http://dx.doi.org/10.1080/09513590.2018.1538347DOI Listing
February 2019
1 Read

Twist1 was detected in mesenchymal cells of mammary fibroadenoma and invasive components of breast carcinoma in rats.

J Toxicol Pathol 2019 Jan 1;32(1):19-26. Epub 2018 Sep 1.

Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.

Fibroadenoma (FA) is a common mammary fibroepithelial tumor. The tumor size of the FA is increased by estrogen, progesterone, prolactin, and pregnancy, whereas it decreases after menopause. These observations in humans indicate that FA is hormone dependent. Read More

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http://dx.doi.org/10.1293/tox.2018-0029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361665PMC
January 2019
1 Read

Sex Hormone Replacement Therapy in Periodontology - A Systematic Review.

Oral Dis 2019 Feb 10. Epub 2019 Feb 10.

Department of Stomatology, Federal University of Paraná (UFPR), Curitiba, PR, Brazil.

Objective: To analyse whether sex hormone replacement therapy (HRT) improves periodontal parameters and dental implants osseointegration in humans.

Materials And Methods: Electronic databases and hand searches were performed from June to August 2018 in SciELO, LILACS and PubMed/Medline. Human observational and interventional studies that evaluated the following parameters were included: Clinical Attachment Loss (CAL), Probing Pocket Depth (PPD), Bleeding on Probing (BOP), Radiographic Bone Loss (RBL) or osseointegration. Read More

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http://dx.doi.org/10.1111/odi.13059DOI Listing
February 2019
1 Read

Cardiovascular response of postmenopausal women to 8 weeks of sprint interval training.

Eur J Appl Physiol 2019 Feb 9. Epub 2019 Feb 9.

School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, 2052, Australia.

Introduction: Menopause is accompanied by decreased aerobic fitness and increased risk of cardiovascular disease. Sprint interval training (SIT) is a time-efficient intervention for improving cardiovascular function and aerobic fitness of young adults.

Aim: To determine the effect of an 8-week SIT program on the cardiovascular function and aerobic fitness of overweight postmenopausal women. Read More

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http://dx.doi.org/10.1007/s00421-019-04087-9DOI Listing
February 2019

[Assessment of the relationship between bmd and body mass index bmi in women with postmenopausal osteoporosis].

Wiad Lek 2018 ;71(9):1714-1718

Zakład Patofizjologii, Katedra Patofizjologii i Endokrynologii, Śląski Uniwersytet Medyczny, Zabrze, Polska.

Objective: Introduction: Osteoporosis is chronic metabolic disease of the bone-joint system and it is increase risk of bone fractures and mortality. The effect of postmenopausal hormonal changes can be the adipose tissue gain along. Osteoporosis and decreased BMD in women with menopause can be a result of the change of body mass. Read More

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January 2018
1 Read

The association between weight at birth and breast cancer risk revisited using Mendelian randomisation.

Eur J Epidemiol 2019 Feb 8. Epub 2019 Feb 8.

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Observational studies suggest that higher birth weight (BW) is associated with increased risk of breast cancer in adult life. We conducted a two-sample Mendelian randomisation (MR) study to assess whether this association is causal. Sixty independent single nucleotide polymorphisms (SNPs) known to be associated at P < 5 × 10 with BW were used to construct (1) a 41-SNP instrumental variable (IV) for univariable MR after removing SNPs with pleiotropic associations with other breast cancer risk factors and (2) a 49-SNP IV for multivariable MR after filtering SNPs for data availability. Read More

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http://dx.doi.org/10.1007/s10654-019-00485-7DOI Listing
February 2019
2 Reads

Immunometabolic Links between Estrogen, Adipose Tissue and Female Reproductive Metabolism.

Biology (Basel) 2019 Feb 7;8(1). Epub 2019 Feb 7.

Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.

The current knowledge of sex-dependent differences in adipose tissue biology remains in its infancy and is motivated in part by the desire to understand why menopause is linked to an increased risk of metabolic disease. However, the development and characterization of targeted genetically-modified rodent models are shedding new light on the physiological actions of sex hormones in healthy reproductive metabolism. In this review we consider the need for differentially regulating metabolic flexibility, energy balance, and immunity in a sex-dependent manner. Read More

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http://dx.doi.org/10.3390/biology8010008DOI Listing
February 2019

Efficacy of a Homeopathic Medicine of Capsicum frutescens L. (Solanaceae) in the Treatment of Hot Flashes in Menopausal Women: A Phase-2 Randomized Controlled Trial.

Homeopathy 2019 Feb 8. Epub 2019 Feb 8.

Department of Plant Biotechnology, University of Ribeirão Preto (UNAERP), Ribeirão Preto, Brazil.

Background:  Hot flashes are common in women during menopause, and are an important cause of discomfort, increasing the number of medical appointments. Hormone replacement therapy is an effective treatment, but it can bring undesirable consequences. Alternative treatments exist but they are not universally accepted or effective. Read More

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http://dx.doi.org/10.1055/s-0038-1676326DOI Listing
February 2019
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Cardiovascular Effect of Diosgenin in Ovariectomized Rats.

J Med Food 2019 Feb 8. Epub 2019 Feb 8.

1 Medicinal Plants Research Center-PI, Terezina, Piauí, Brazil.

Diosgenin is a phytoestrogen and a constituent of Dioscorea. It has several biological effects, and some of them are anti-inflammatory, antidiabetic, antitumor, and vasodilatory. The present study investigated both the vasorelaxing and antioxidant mechanisms of diosgenin in isolated rat aortic rings. Read More

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https://www.liebertpub.com/doi/10.1089/jmf.2018.0019
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http://dx.doi.org/10.1089/jmf.2018.0019DOI Listing
February 2019
2 Reads

Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential.

Oxid Med Cell Longev 2019 10;2019:5713606. Epub 2019 Jan 10.

College of Applied Medical Sciences, Department of Medical Laboratory Sciences, University of Bisha, Saudi Arabia.

Hormone replacement therapy (HRT) can alleviate estrogen deficiency symptoms especially during menopause. The present study aimed at investigating the effect of soy isoflavones as HRT on immunological and bone health-related parameters with a special focus on the interactions between immunological status and metabolism. Thirty healthy cyclic female Wistar rats were used in this experiment. Read More

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http://dx.doi.org/10.1155/2019/5713606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348823PMC
January 2019
1 Read

Menopause: Women should not suffer in silence.

Maturitas 2019 Jan 30. Epub 2019 Jan 30.

Department of Clinical and Experimental Medicine, University of Pisa, Via Roma, 67, 56126, Pisa, Italy.

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http://dx.doi.org/10.1016/j.maturitas.2019.01.014DOI Listing
January 2019

An unusual cause of postmenopausal vaginal haemorrhage: a case report.

BMC Womens Health 2019 Feb 7;19(1):31. Epub 2019 Feb 7.

The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, 145, Guang-yuan Road, Xuhui District, Shanghai, 200030, China.

Background: Post-menopause vaginal haemorrhage is typically related to gynaecological malignancies. Bleeding from vaginal varices rarely occurs, especially in nonpregnant women. Moreover, nonpregnancy-related causes of vaginal varicosities include portal hypertension, especially that caused by liver cirrhosis, pelvic congestion syndrome and Klippel-Trenaunay syndrome or Parkes-Weber syndrome. Read More

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https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12905-019-0731-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367833PMC
February 2019
2 Reads

Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review.

Nutr J 2019 Feb 7;18(1). Epub 2019 Feb 7.

Department of Gastroenterology and Hepatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Celiac disease (CD) is known as a reason of metabolic osteopathy. Progression of non-invasive methods such as bone densitometry has shown that an important ratio of CD cases is faced with impaired bone mass and such cases are prone to bone fractures. Variety of low bone mineral density in CD is probably because of ignored confounding factors such as age, menopause, and drug. Read More

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http://dx.doi.org/10.1186/s12937-019-0434-6DOI Listing
February 2019
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Epidemiology and Management Challenges in Prolactinomas.

Neuroendocrinology 2019 Feb 7. Epub 2019 Feb 7.


Clinically relevant pituitary adenomas are present in about 1 per 1000 of the general population and prolactinomas are by far the most common clinical subtype of pituitary adenomas. Usually prolactinomas affect pre-menopausal women and present with typical symptoms of menstrual disturbance and/or galactorrhea. They are generally managed with dopamine agonists to restore fertility and to control symptoms and tumour size. Read More

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http://dx.doi.org/10.1159/000497746DOI Listing
February 2019
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Recent Advances in Fertility Preservation and Counseling for Reproductive Aged Women with Colorectal Cancer: A Systematic Review.

Dis Colon Rectum 2019 Feb 5. Epub 2019 Feb 5.

Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.

Background: The incidence of colorectal cancer among reproductive-aged women is increasing. Concerns regarding future fertility are secondary only to concerns regarding survival and may significantly impact quality of life among reproductive-aged female cancer survivors. Fertility preservation counseling reduces long-term regret and dissatisfaction among cancer survivors. Read More

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http://dx.doi.org/10.1097/DCR.0000000000001351DOI Listing
February 2019
2 Reads

Residential Exposure to PM and Ozone and Progression of Subclinical Atherosclerosis Among Women Transitioning Through Menopause: The Study of Women's Health Across the Nation.

J Womens Health (Larchmt) 2019 Feb 7. Epub 2019 Feb 7.

1 Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania.

Objective: This article aims to examine the association between long-term ambient air pollution and progression of subclinical atherosclerosis with 2-year follow-up among midlife women from the Study of Women's Health Across the Nation (SWAN).

Methods: Carotid duplex ultrasonography was performed in participants from a SWAN ancillary study carried out at the Pittsburgh and Chicago sites. Mean and maximum carotid intima-media thickness (CIMT) and plaque burden were assessed throughout the common, bulb, and internal carotid artery. Read More

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http://dx.doi.org/10.1089/jwh.2018.7182DOI Listing
February 2019
2 Reads

Unrecognized Pseudohypoparathyroidism Type 1A as a Cause of Hypocalcemia and Seizures in a 64-Year-Old Woman.

Case Rep Endocrinol 2019 9;2019:8456239. Epub 2019 Jan 9.

Department of Health Sciences, University of Genoa; Medical Genetics Unit, Galliera Hospital, Genoa, Italy.

Pseudohypoparathyroidism type 1A (PHP1A) is usually diagnosed in childhood or early adulthood. We describe the case of a 64-year-old woman admitted to the Neurological Unit for recurrent episodes of loss of consciousness and seizures. Glycemia and ECG were normal, while hypocalcemia was noted. Read More

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http://dx.doi.org/10.1155/2019/8456239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343178PMC
January 2019
1 Read