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Neuroendocrinology 2022 Jun 27. Epub 2022 Jun 27.

Neuroactive steroids can be synthetic or endogenous molecules produced by neuronal and glial cells, and peripheral glands. Examples include estrogens, testosterone, progesterone and its reduced metabolites such as 5-dihydroprogesterone and allopregnanolone. Steroids produced by neurons and glia target the nervous system and are called neurosteroids. Read More

Womens Health (Lond) 2022 Jan-Dec;18:17455057221106890

Reproductive Medicine Unit, University College Hospital, London, UK.

Introduction: Women are not usually taught about the menopause formally, and many general practitioners have relatively little training. The aim of this study was to explore perimenopausal women's attitudes and knowledge of the menopause.

Method: An online survey was designed to evaluate attitudes and knowledge of the menopause in women older than 40 years. Read More

Front Endocrinol (Lausanne) 2022 10;13:879384. Epub 2022 Jun 10.

Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China.

Reproductive factors have been demonstrated to be associated with hyperuricemia. Body composition is an essential determinant influencing serum uric acid (SUA), but it is largely unknown whether increased SUA was influenced by changed body composition during the menopausal transition. As a secondary analysis of China National Health Survey from 2012-to 2017, this study included 18,997 women aged 20 to 80. Read More

Front Endocrinol (Lausanne) 2022 10;13:876775. Epub 2022 Jun 10.

Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.

Backgrounds: A large number of studies have investigated the effect of early menopause on cardiovascular disease (CVD) outcomes and the relationship between the levels of lipid profile and primary ovarian insufficiency (POI). However, the results are inconsistent. The aim of this meta-analysis was to assess whether the levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) changed in women with POI relative to healthy controls. Read More

Front Cardiovasc Med 2022 10;9:913609. Epub 2022 Jun 10.

Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Background: Postmenopausal hormone therapy (HT) is associated with increased cardiovascular risk. Although the route of estrogen administration may play a role in mediating risk, previous studies have not controlled for concomitant progestin use.

Objective: To investigate the association between the route of estrogen therapy (oral or non-oral) HT use, without concomitant progestin, and blood pressure and arterial stiffness in postmenopausal women. Read More

Front Psychol 2022 10;13:763596. Epub 2022 Jun 10.

School of Humanities, Tongji University, Shanghai, China.

Although previous studies showed that women's menopause-related symptoms varied in different ethnic groups and countries, and were affected by specific social and cultural factors, few studies have been conducted to explore menopause-related symptoms and its influencing factors in middle-aged women among ethnic groups in China. This study aimed to explore the characteristics of menopause-related symptoms and its influencing factors among Mosuo, Yi, and Han women in Yongning area of Yunnan province, China. A cross-cultural design by snowball sampling method was used to recruit 208 women aged 40-60 from Yongning Township, Ninglang County, Yunnan province, China. Read More

Compr Psychoneuroendocrinol 2020 Nov 30;4:100019. Epub 2020 Nov 30.

Pharmacology and Toxicology Laboratory, CSIR-Institute of Himalayan Bioresource Technology, Palampur, 176061, Himachal Pradesh, India.

Glycogen synthase kinase-3 (Gsk-3β) aberration act as a crucial pathogenic factor in several neurological conditions. However its role in menopause associated behavioural impairments is still not unclear. The present study was designed to understand the role of Gsk-3β in the progression of neurobehavioural impairments in middle-aged ovariectomized (ovx) rats. Read More

Front Med (Lausanne) 2022 9;9:905085. Epub 2022 Jun 9.

Department of Family Medicine and Division of General Internal Medicine, Department of Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, State Key Laboratory of Complex Severe and Rare Diseases (Peking Union Medical College Hospital), Beijing, China.

Background: There is a limited number of studies on the dose-response relationship between serum uric acid and impaired glucose metabolism in people without diabetes, and no large-scale research exploring the relationship in women without diabetes is based on menopausal status. Consequently, the present study aimed to investigate the above relationship in United States adults without diabetes.

Materials And Methods: Data from 2,498 men and 2,650 women aged ≥20 years were obtained from the National Health and Nutrition Examination Survey 2011-2016 conducted in the United States. Read More

iScience 2022 Jul 3;25(7):104527. Epub 2022 Jun 3.

Immunoendocrinology Lab, National Institute of Immunology, New Delhi, Delhi 110067, India.

The post-menopausal state in women is associated with increased cancer incidence, the reasons for which remain obscure. Curiously, increased circulating levels of beta-hCG (human chorionic gonadotropin) (a hormonal subunit linked with tumors of several lineages) are also often observed post-menopause. This study describes a previously unidentified interplay between beta-hCG and progesterone in tumorigenesis. Read More

Aust N Z J Obstet Gynaecol 2022 Jun 26. Epub 2022 Jun 26.

Endosurgery (Gynaecology) Department, Mercy Hospital for Women, Heidelberg, Melbourne, Victoria, Australia.

Background: Postmenopausal bleeding (PMB), a common symptom of endometrial cancer, necessitates prompt clinical and sonographic assessment, often followed by hysteroscopy. Unfortunately, due to traditional gynaecology outpatient clinic paradigms, unnecessary patient-clinician encounters are common and may lead to delays in diagnosis.

Aim: The aim was to assess a novel clinic model for the management of women with PMB based on virtual assessment and routine use of the outpatient hysteroscopy clinic. Read More

J Obstet Gynaecol Can 2022 Jun 23. Epub 2022 Jun 23.

Centre Hospitalier de l'Université de Montréal, Department of Obstetrics-Gynaecology of the Université de Montréal, Montreal, QC, 1000 rue Saint-Denis, Montréal, Québec, Canada, H2X 0C1.

The appropriate age at which to perform endometrial biopsy for abnormal uterine bleeding (AUB) is controversial. This study aimed to determine the prevalence of malignant and premalignant pathologies in women aged 41-49 years with AUB and without risk factors for endometrial cancer. Records of women who had undergone a biopsy at the gynaecology clinic of the Centre hospitalier de l'Université de Montréal between 2014 and 2018 were reviewed. Read More

Sci Total Environ 2022 Jun 23:156891. Epub 2022 Jun 23.

West Virginia University School of Public Health, Morgantown, WV, USA.

Gender-age specific linear statistical models were fitted to analyze gender-based differences in serum concentrations of PFOA, PFNA, PFHxS, and PFOS for US adults and adolescents (N = 17,932) and children age < 12 years (N = 637) using nationally representative data for US for 2003-2018. Around the age of about 11-12 years for PFOS, PFNA, and PFNA, and around 15 years for PFOA, females begin to have reliably lower serum PFAS than males. This divergence is maximized around the ages of about 35 to 40 years for the alkylate compounds PFOA and PFNA, and from around 24-52 years for the sulfonate compounds PFOS and PFHxS. Read More

Nutr Metab Cardiovasc Dis 2022 Jun 8. Epub 2022 Jun 8.

Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.

Background And Aims: Menopause may reduce fat oxidation. We investigated whether sex hormone profile explains resting fat oxidation (RFO) or peak fat oxidation (PFO) during incremental cycling in middle-aged women. Secondarily, we studied associations of RFO and PFO with glucose regulation. Read More

J Sex Med 2022 Jul;19(7):1098-1115

Department of Obstetrics and Gynecology, University Hospitals Schleswig-Holstein, Kiel, Germany.

Background: Changes in sex hormones during menopause may have detrimental effects on a woman's sexual function and cause mood disorders. The treatment of both conditions is a challenge in gynecology.

Aim: To review the published literature on sexual function and mood disorders among peri- and postmenopausal women. Read More

Psychooncology 2022 Jun 25. Epub 2022 Jun 25.

Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, USA.

Objective: Colorectal cancer poses a significant threat to both psychological and physical health. This study examined relationships between anxiety and depressive symptoms with pain, fatigue, and inflammation among colorectal patients.

Methods: Colorectal cancer patients (n = 88, stages 0-IV) completed a laboratory-based study visit before undergoing adjuvant cancer treatment. Read More

Mol Psychiatry 2022 Jun 24. Epub 2022 Jun 24.

Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan.

Reproductive behaviors are associated with risks for psychiatric disorders. Reproductive phenotypes are moderately heritable and have genetic overlaps with risks for psychiatric disorders. However, the genetic and causal relationships between anxiety-related disorders or specific anxiety disorders and reproductive phenotypes remain unknown. Read More

J Expo Sci Environ Epidemiol 2022 Jun 24. Epub 2022 Jun 24.

Department of Orthopaedics, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.

Background: Environmental exposures such as perfluoroalkyl substances (PFASs) were considered potential risks for bone mineral density (BMD).

Objective: To examine the associations between PFASs and BMD among the U.S. Read More

Seizure 2022 Jun 16;100:36-43. Epub 2022 Jun 16.

Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, University Hospital Frankfurt, Goethe-University Frankfurt, Frankfurt am Main, Germany; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, Frankfurt am Main, Germany.

Objective: Epilepsy is a chronic condition that can affect patients of all ages. Women with epilepsy (WWE) require access to specific counseling and information regarding issues related to contraception, pregnancy, and hormonal effects on seizure control and bone mineral density. This study investigated the knowledge among WWE regarding their condition, and whether epilepsy-specific knowledge has improved over the last 15 years. Read More

Yonsei Med J 2022 Jul;63(7):648-656

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

Purpose: In women, menopause manifests with a variety of symptoms related to sex-hormone deficiency. Supplementing steroid hormones with pharmacological drugs has been widely practiced. However, considering the possible complications associated with artificial hormone therapy, studies have been conducted to find an alternative to pharmacological hormone replacement therapy. Read More

Clin Interv Aging 2022 17;17:971-978. Epub 2022 Jun 17.

Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea.

Background: Chronic inflammation plays a key role in the pathophysiology of frailty and loss of physical performance, which are closely associated with sarcopenia. In women, the decline in muscle mass and strength is accelerated after menopause. Thus, we examined the association between high sensitivity C-reactive protein (hs-CRP) and relative handgrip strength (HGS) in postmenopausal women. Read More

Nutrients 2022 Jun 14;14(12). Epub 2022 Jun 14.

Department of Virology with SARS Laboratory, Medical University of Lublin, 20-093 Lublin, Poland.

The aim of this report was to determine the impact of flaxseed, soy and red clover, and their bioactive substances on the lipid profile in postmenopausal women in cardiovascular diseases prevention. We used the following databases: MEDLINE (PubMed), EMBASE and the Cochrane Library. Meta-analysis indicates that the intake of flaxseed by postmenopausal women is associated with a statistically significant reduction in total cholesterol (TC) levels (weighted-mean difference (WMD) = -0. Read More

Nutrients 2022 Jun 10;14(12). Epub 2022 Jun 10.

Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.

Crohn's disease (CD) is a chronic inflammatory disease (IBD) that can affect the entire gastrointestinal tract in a non-continuous mode. CD is generally diagnosed most commonly between 15 and 35 years of age and may affect female fertility. The role of diet in supporting wellbeing outcome and reproductive potential in women is well-known; however, no effective efforts have been made to improve women's awareness in CD. Read More

Molecules 2022 Jun 19;27(12). Epub 2022 Jun 19.

Unit of Metabolic Bone and Thyroid Disorders, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy.

The dipeptidyl peptidase 3 () is a ubiquitous zinc-dependent aminopeptidase, participating in the activation or degradation of signaling peptides and in the Keap1-Nrf2 antioxidant pathway. The absence of in the knockout mouse model causes increased osteoclast activity, altered osteogenic function, sustained oxidative stress in the bone tissue, and bone loss. We aimed to assess the association of activity with bone fragility in postmenopausal osteoporosis and the impact of denosumab on enzymatic activity. Read More

Medicina (Kaunas) 2022 Jun 6;58(6). Epub 2022 Jun 6.

Obstetrics and Gynecology Unit, IRCCS San Raffaele Hospital, Vita-Salute University, 20132 Milan, Italy.

Vulvovaginal atrophy (VVA) is a chronic progressive disease involving the female genital apparatus and lower urinary tract. This condition is related to hypoestrogenism consequent to menopause onset but is also due to the hormonal decrease after adjuvant therapy for patients affected by breast cancer. Considering the high prevalence of VVA and the expected growth of this condition due to the increase in the average age of the female population, it is easy to understand its significant social impact. Read More

J Clin Med 2022 Jun 12;11(12). Epub 2022 Jun 12.

General Hospital Kavala Greece, 65500 Kavala, Greece.

Introduction: Menopause is a physiological period in a woman's life, but it is often accompanied by symptoms that affect mental well-being and general health, including a tendency for depression.

Aim Of The Study: To evaluate the predisposition to the symptoms of depression in women from Poland, Belarus, Belgium, and Greece.

Material And Methods: the method of diagnostic survey was used, and the research tools were: The Menopause Rating Scale, the Kupperman Index, Beck Depression Inventory, and a self-made survey questionnaire. Read More

Healthcare (Basel) 2022 Jun 14;10(6). Epub 2022 Jun 14.

AIDX, Inc., Yongin-si 16954, Korea.

As osteoporosis is a degenerative disease related to postmenopausal aging, early diagnosis is vital. This study used data from the Korea National Health and Nutrition Examination Surveys to predict a patient's risk of osteoporosis using machine learning algorithms. Data from 1431 postmenopausal women aged 40-69 years were used, including 20 features affecting osteoporosis, chosen by feature importance and recursive feature elimination. Read More

Biomedicines 2022 Jun 11;10(6). Epub 2022 Jun 11.

Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

Embryo selection is needed to optimize the chances of pregnancy in assisted reproduction technology. This study aimed to validate non-invasive preimplantation genetic testing for aneuploidy (niPGT-A) using a routine IVF laboratory workflow. Can niPGT-A combined with time-lapse morphokinetics provide a better embryo-selection strategy? A total of 118 spent culture mediums (SCMs) from 32 couples were collected. Read More

Maturitas 2022 Jun 9;164:1-8. Epub 2022 Jun 9.

Menopause/Reproductive Endocrine Services, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK. Electronic address:

Objectives: To describe the epidemiology and treatment of vasomotor symptoms (VMS) in the UK.

Study Design: Retrospective study that used electronic medical records from UK primary care centers.

Main Outcome Measures: The prevalence and incidence of moderate-to-severe VMS, the proportion treated, persistence with initial treatment, treatment patterns, and menopausal hormone therapy (HT) experience were investigated over the study period (Jan. Read More

Neurobiol Aging 2022 Jun 3;117:139-150. Epub 2022 Jun 3.

Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, USA; Department of Psychological & Brain Sciences, Texas A&M University, College Station, TX, USA.

Sex-specific differences in the aging cerebellum may be related to hormone changes with menopause. We evaluated the association between reproductive stage and lobular cerebellar network connectivity using data from the Cambridge Centre for Ageing and Neuroscience repository. We used raw structural and resting state neuroimaging data and information regarding age, sex, and menopause-related variables. Read More

Metabolites 2022 Jun 16;12(6). Epub 2022 Jun 16.

Biochemistry Research Laboratory, Omsk State Pedagogical University, 14 Tukhachevsky str, 644043 Omsk, Russia.

Despite the fact that breast cancer was detected in the early stages, the prognosis was not always favorable. In this paper, we examined the impact of clinical and pathological characteristics of patients and the composition of saliva before treatment on overall survival and the risk of recurrence of primary resectable breast cancer. The study included 355 patients of the Omsk Clinical Oncology Center with a diagnosis of primary resectable breast cancer (TNM). Read More