Am J Pathol 2021 Jun 5. Epub 2021 Jun 5.
Thrombosis and Atherosclerosis Research Institute, , McMaster University, Hamilton, Ontario, Canada, 237 Barton Street East Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada, 237 Barton Street East Hamilton, Ontario, Canada. Electronic address:
Insulin resistance results when peripheral tissues, including adipose, skeletal muscle and liver, do not respond appropriately to insulin causing the ineffective uptake of glucose. This represents a risk factor for the development of type 2 diabetes mellitus. Along with abdominal obesity, hypertension, high levels of triglycerides, and low levels of high-density lipoproteins, insulin resistance is a component of a condition known as the metabolic syndrome, which significantly increases the risk of developing cardiometabolic disorders. Read More