67,122 results match your criteria Menopause


Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study.

Redox Biol 2019 Apr 15;24:101204. Epub 2019 Apr 15.

Department of Physiology and Pharmacology, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Recently, Weber et al. published a thorough investigation of the age-dependency of oxidative stress (OS) determined by the steady state concentrations of different compounds - oxidation products and antioxidants - that are in common use as biomarkers of OS in 2207 healthy individuals of the cross-sectional MARK-AGE Project. The correlations among biomarkers were significant but weak. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101204DOI Listing

Ovarian progesterone suppresses depression and anxiety-like behaviors by increasing the Lactobacillus population of gut microbiota in ovariectomized mice.

Neurosci Res 2019 Apr 22. Epub 2019 Apr 22.

Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Japan. Electronic address:

Depression and anxiety, which are severe symptoms during menopause, are caused by ceased ovarian activity and declined serum progesterone levels. Studies have demonstrated that gut microbiota can regulate brain function and change the microbiota composition during the perimenopause period. This study investigated whether progesterone affects depressant and anxious behaviors via gut microbiota. Read More

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http://dx.doi.org/10.1016/j.neures.2019.04.005DOI Listing

Adnexal tumors in menopausal women: surgery or surveillance?

Menopause 2019 May;26(5):554-556

Department of Obstetrics and Gynecology, University of Kentucky, Lexington, Kentucky.

Asymptomatic ovarian tumors in menopausal women do not always require surgical removal. Experts recommend an initial evaluation with transvaginal ultrasound to help characterize the tumor's malignant risk. Low-risk tumors can be monitored with ultrasound, whereas high-risk tumors should be referred to a gynecologic oncologist. Read More

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http://dx.doi.org/10.1097/GME.0000000000001330DOI Listing

Comparative efficacy and safety of pharmacological interventions for osteoporosis in postmenopausal women: a network meta-analysis (Chongqing, China).

Menopause 2019 Apr 22. Epub 2019 Apr 22.

Department of Gynecology, People's Hospital of Rongchang District, Chongqing, China.

Objective: The aim of this study was to assess the comparative effectiveness and safety of different pharmacological agents, including abaloparatide and romosozumab, for treatment of osteoporosis in postmenopausal women.

Methods: We searched PubMed, Embase, the Cochrane Central Register of Controlled Trials, and Google Scholar for relevant randomized controlled trials published up to July 16, 2018. After study selection according to the preplanned criteria, we performed data extraction and quality assessment. Read More

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http://Insights.ovid.com/crossref?an=00042192-900000000-9738
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http://dx.doi.org/10.1097/GME.0000000000001321DOI Listing
April 2019
1 Read

No vaginal estrogen therapy arm in an RCT trial on genitourinary syndrome of menopause is a concern.

Climacteric 2019 Apr 24. Epub 2019 Apr 24.

b Department of Gynecology , Wesley Hospital , Brisbane , Australia.

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https://www.tandfonline.com/doi/full/10.1080/13697137.2019.1
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http://dx.doi.org/10.1080/13697137.2019.1597842DOI Listing
April 2019
1 Read

Inverse association between physical activity and blood glucose is independent of sex, menopause status, and first-degree family history of diabetes.

J Diabetes Investig 2019 Apr 23. Epub 2019 Apr 23.

Department of Endocrine and Metabolic Diseases, the First Affiliated Hospital of Wenzhou Medical University, Ouhai District, Wenzhou, 325000, Zhejiang Province, China.

Aims: Exercise training is a recognized strategy central to the prevention, treatment and management of diabetes and prediabetes. The present study was to investigate the association between physical activity and blood glucose, as well as the influence of sex, menopause status, and family history of diabetes.

Materials And Methods: Participants with normal weight were selected from REACTION study, and divided into inactive (moderate-to-vigorous-intensity physical activity [MVPA] < 30 min/week), low-degree (MVPA ≥ 30 and ≤ 420 min/week), and high-degree (MVPA > 420 min/week) active groups. Read More

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http://dx.doi.org/10.1111/jdi.13062DOI Listing

Vitamin D restriction enhances periovarian adipose tissue inflammation in a model of menopause.

Climacteric 2019 Apr 23:1-6. Epub 2019 Apr 23.

a Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Center, Institute of Biology , The University of the State of Rio de Janeiro , Rio de Janeiro , Brazil.

Background: Menopause and deficiency in vitamin D (VD) are two health problems usually associated with aging women.

Objective: We aimed to study inflammation in visceral adipose tissue when bilateral ovariectomy is combined with dietary restriction in VD.

Methods: We studied 60 female C57BL/6 mice 3 months of age. Read More

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http://dx.doi.org/10.1080/13697137.2019.1597841DOI Listing

Longitudinal impact of the Women's Health Initiative study on hormone therapy use in Australia.

Climacteric 2019 Apr 23:1-9. Epub 2019 Apr 23.

a School of Pharmacy , University of Queensland , Woolloongabba , QLD , Australia.

Purpose: This study aimed to examine the longitudinal impact of evidence changes on menopausal hormone therapy (MHT) use in Australia.

Methods: We analyzed two datasets of subsidized and total MHT use (2000-2016) using segmented regression analysis to explore the impact of the Women's Health Initiative (WHI) 2002 and 2007 studies. Analyses were stratified by class, route, and strength. Read More

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http://dx.doi.org/10.1080/13697137.2019.1593357DOI Listing
April 2019
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Association between Inflammatory Potential of Diet and Bone-Mineral Density in Korean Postmenopausal Women: Data from Fourth and Fifth Korea National Health and Nutrition Examination Surveys.

Nutrients 2019 Apr 19;11(4). Epub 2019 Apr 19.

Department of Food and Nutrition, Wonkwang University, 460 Iksandaero, Iksan, Jeonbuk 54538, Korea.

Post menopause is considered a critical period for bone-mass loss. Impaired bone metabolism during this phase can increase the risk of fractures in old age. Inflammation is a risk factor for bone health, and diet is a potential source of inflammation. Read More

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http://dx.doi.org/10.3390/nu11040885DOI Listing

The risk of malignancy in uterine polyps: A systematic review and meta-analysis.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 15;237:48-56. Epub 2019 Apr 15.

Department of Woman, Newborn and Child, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, Università degli studi di Milano, Milan, Italy. Electronic address:

Background: Endometrial polyps are a common condition. The risk of malignancy has often led to an overtreatment with high health care costs and huge psychological distress.

Objective: We conducted a systematic review and a meta-analysis in order to estimate the prevalence of premalignant and malignant lesions in women undergoing hysteroscopic polypectomy. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.04.009DOI Listing

Kuntai capsule attenuates premature ovarian failure through the PI3K/AKT/mTOR pathway.

J Ethnopharmacol 2019 Apr 19:111885. Epub 2019 Apr 19.

Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, 210023, China; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China. Electronic address:

Ethnopharmacological Relevance: Kuntai capsule (KTC), a type of herb formulas, was first described in the book of Shang Han Za Bing Lun in the third century. KTC has been widely used for the clinical treatment of menopausal syndrome. Considering that premature ovarian failure is also known as premature menopause, this study was designed to investigate the effects and mechanisms of KTC on a mouse model of premature ovarian failure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183378
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http://dx.doi.org/10.1016/j.jep.2019.111885DOI Listing
April 2019
2 Reads

Medical and information needs among young women with breast cancer in Mexico.

Eur J Cancer Care (Engl) 2019 Apr 22:e13040. Epub 2019 Apr 22.

Joven & Fuerte: Program for the Care and Research of Young Women with Breast Cancer in Mexico, Mexico City, Mexico.

Objective: To describe clinical and information needs, identify unmet support services and guide interventions for young breast cancer (BC) patients in Mexico.

Methods: Cross-sectional, qualitative study, using interpretive description methodology. Patients with initial BC diagnosis within 6-12 months prior to enrolment, ≤40 years old and literate were included in focus groups. Read More

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http://dx.doi.org/10.1111/ecc.13040DOI Listing

Can menopause prediction be improved with multiple AMH measurements? Results from the prospective Doetinchem Cohort Study.

J Clin Endocrinol Metab 2019 Apr 22. Epub 2019 Apr 22.

Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands.

Context: Anti-Müllerian hormone (AMH) levels are currently used worldwide as a screening tool for the duration of the female reproductive lifespan. Although AMH levels are associated with age at menopause, individual predictions of menopause with a single AMH measurement are unreliable.

Objective: This study investigated whether individual AMH decline patterns can improve the prediction of menopause compared to a single measurement. Read More

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http://dx.doi.org/10.1210/jc.2018-02607DOI Listing

Risk factors associated with coronary artery calcification in midlife women: a population-based study.

Gynecol Endocrinol 2019 Apr 22:1-5. Epub 2019 Apr 22.

d Gynecological Endocrinology Unit, Division of Endocrinology , Hospital de Clínicas de Porto Alegre , Porto Alegre , Brazil.

The aim of this study was to investigate the association between individual risk factors and coronary artery calcification (CAC), as a marker of subclinical cardiovascular disease, in a population-based nested cross-sectional study of midlife women. Anthropometric and metabolic data from 295 women from the South of Brazil were analyzed. Habitual physical activity was assessed by pedometer. Read More

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https://www.tandfonline.com/doi/full/10.1080/09513590.2019.1
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http://dx.doi.org/10.1080/09513590.2019.1604656DOI Listing
April 2019
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Potential risk factors of ovarian cancer and analysis of CA125, a biomarker used for its monitoring and diagnosis.

Mol Biol Rep 2019 Apr 20. Epub 2019 Apr 20.

School of Life and Environmental Sciences, University of Sydney, Sydney, Australia.

Ovarian cancer (OC) is the fourth most common cancer among Pakistani, Scottish and Chinese women. The aim of the present study was to determine the association of potential risk factors with OC and analysis of Cancer Antigen 125 (CA125) in its monitoring and diagnosis. A total of 200 patients diagnosed with OC were included in this study. Read More

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http://dx.doi.org/10.1007/s11033-019-04794-8DOI Listing

Reproductive Health of Women Veterans: A Systematic Review of the Literature from 2008 to 2017.

Semin Reprod Med 2018 Nov 19;36(6):315-322. Epub 2019 Apr 19.

Division of Gynecology, Department of Surgery, VA Boston Healthcare System, Boston, Massachusetts.

The literature on the reproductive health and healthcare of women Veterans has increased dramatically, though there are important gaps. This article aims to synthesize recent literature on reproductive health and healthcare of women Veterans. We updated a literature search to identify manuscripts published between 2008 and July 1, 2017. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678750
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http://dx.doi.org/10.1055/s-0039-1678750DOI Listing
November 2018
2 Reads

Circulating PCSK9 concentrations are increased in postmenopausal women with the metabolic syndrome.

Clin Chim Acta 2019 Apr 16;494:151-156. Epub 2019 Apr 16.

School of Allied Health Sciences, Walailak University, 222 Thaiburi, Thasala, Nakhon Si Thammarat, Thailand. Electronic address:

Background: High PCSK9 concentrations are associated with an increased risk of cardiovascular disease (CVD). We investigated PCSK9 concentrations and their association with metabolic parameters in Thai subjects and to compare PCSK9 concentrations in pre- and postmenopausal women with and without metabolic syndrome (MetS).

Methods: Anthropometric data, serum lipids, fasting blood glucose (FBG), and PCSK9 concentrations were measured in 436 Thai subjects (152 men, 143 premenopausal, and 141 postmenopausal women). Read More

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http://dx.doi.org/10.1016/j.cca.2019.04.067DOI Listing

Cabergoline Withdrawal Before and After Menopause: Outcomes in Microprolactinomas.

Horm Cancer 2019 Apr 18. Epub 2019 Apr 18.

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Natural course of prolactinomas after menopause is not fully elucidated. The aim of this study was to compare recurrence rate after cabergoline withdrawal in premenopausal vs. postmenopausal women with microprolactinoma. Read More

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http://dx.doi.org/10.1007/s12672-019-00363-4DOI Listing

Prevalence of Depression and its Association with Sociodemographic Factors in Postmenopausal Women in an Urban Resettlement Colony of Delhi.

J Midlife Health 2019 Jan-Mar;10(1):33-36

Department of Obstetrics and Gynaecology, Maulana Azad Medical College, Delhi, India.

Background: Menopause is defined as the time of cessation of ovarian function resulting in permanent amenorrhea. Menopause is associated with various symptoms such as physical, vasomotor, sexual, and psychological symptoms. Depression is a common symptom in postmenopausal women as menopause is associated with the end of the fertile period of a women's life. Read More

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http://www.jmidlifehealth.org/text.asp?2019/10/1/33/255280
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http://dx.doi.org/10.4103/jmh.JMH_66_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459070PMC
April 2019
1 Read

Appraisal of Core Therapy, Supportive Therapy, and Alternative Therapy in a Tertiary Care Rural Hospital of Vidarbha Region in Correlation to Plethora of Menopausal Problems.

J Midlife Health 2019 Jan-Mar;10(1):14-21

OBGY, Jawaharlal Nehru Medical College, Wardha, Maharashtra, India.

Context: Menopause is a crucial phase of the women fraternity which marks the end of reproductive age. Mostly it is physiological; however, certain conditions may lead to premature menopause. Menopause has an extensive spectrum of symptoms which are extremely bothersome. Read More

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http://dx.doi.org/10.4103/jmh.JMH_131_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459068PMC

Menopausal Hot Flashes: A Concise Review.

J Midlife Health 2019 Jan-Mar;10(1):6-13

Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Hot flashes (HFs), defined as transient sensations of heat, sweating, flushing, anxiety, and chills lasting for 1-5 min, constitute one of the most common symptoms of menopause among women though only a few seek treatment for these. The basis of HFs lies in abnormal hypothalamic thermoregulatory control resulting in abnormal vasodilatory response to minor elevations of core body temperature. Recent data suggest an important role for calcitonin gene-related peptide, hypothalamic kisspeptin, neurokinin B and dynorphin signal system, serotonin, norepinephrine in causation of HFs in addition to estrogen deficiency which plays a cardinal role. Read More

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http://dx.doi.org/10.4103/jmh.JMH_7_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459071PMC

Presidential speech: President, Indian Menopause Society 2019.

Authors:
Neelam Aggarwal

J Midlife Health 2019 Jan-Mar;10(1):1-2

Professor, Department of Obs Gynae, PGIMER, Chandigarh, Punjab, India. E-mail:

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http://www.jmidlifehealth.org/text.asp?2019/10/1/1/255294
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http://dx.doi.org/10.4103/0976-7800.255294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459063PMC
April 2019
1 Read

Mutational analysis of theFAM175A gene in patients with premature ovarian insufficiency.

Reprod Biomed Online 2019 Feb 28. Epub 2019 Feb 28.

Centre for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, China. Electronic address:

Research Question: The family with sequence similarity 175 member A gene (FAM175A; also known as ABRAXAS1, CCDC98 and ABRA1), a member of the DNA repair family, contributes to the BRCA1 (BRCA1 DNA repair associated)-dependent DNA damage response and is associated with age at natural menopause. However, it remains poorly understood whether sequence variants in FAM175A are causative for premature ovarian insufficiency (POI). The aim of this study was to investigate whether mutations in the gene FAM175A were present in patients with POI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14726483193010
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http://dx.doi.org/10.1016/j.rbmo.2019.02.006DOI Listing
February 2019
1 Read

Estrogen-deficient skin: The role of topical therapy.

Int J Womens Dermatol 2019 Jun 15;5(2):85-90. Epub 2019 Mar 15.

Montefiore Medical Center, Department of Medicine, Division of Dermatology, Bronx, New York.

Menopause is a major turning point in a woman's life that is characterized by declining ovarian function and decreased serum estrogen levels. The resulting hormonal changes particularly affect the skin, with postmenopausal symptoms such as loss of structural architecture and increased propensity to damage becoming rapidly noticeable. Interestingly, studies have shown that estrogen deprivation in postmenopausal conditions accelerates many skin changes, including dryness, atrophy, fine wrinkling, and poor wound healing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23526475193000
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http://dx.doi.org/10.1016/j.ijwd.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451761PMC
June 2019
5 Reads

[Menopausal hormone therapy. Effects on bone and body composition].

Rev Med Suisse 2019 Apr;15(647):836-839

Centre des maladies osseuses, Département de l'appareil locomoteur, CHUV, 1011 Lausanne.

Changes occurring at menopause can be mitigated by prescribing menopausal hormone replacement therapy (HRT). Recent publications from the CoLaus/OsteoLaus cohorts provide important insights into the effects of HRT and after its discontinuation on bone and body composition. HRT has a beneficial effect on bone mineral density, bone microarchitecture and fracture prevention. Read More

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April 2019
3 Reads

Phytotherapeutic medicines: reality or myth?

Rev Assoc Med Bras (1992) 2019 Mar;65(3):292-294

Department of Endocrine Gynecology and Menopause, Discipline of Gynecology and Obstetrics, Hospital das Clínicas, Faculty of Medicine of the University of São Paulo; São Paulo, Brasil.

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1806-9282.65.3.292DOI Listing
March 2019
2 Reads

Cost-effectiveness of antiosteoporosis strategies for postmenopausal women with osteoporosis in China.

Menopause 2019 Apr 15. Epub 2019 Apr 15.

Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.

Objective: Osteoporosis has become an important public health problem in China, especially among elderly postmenopausal women. Massive amounts of medical and health resources have been devoted to patients with osteoporosis and osteoporosis-related fractures. This study estimated the cost-effectiveness of alendronate, zoledronate, raloxifene, teriparatide, and calcium/vitamin D as treatments for osteoporosis in elderly postmenopausal women in China from the medical system perspective. Read More

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http://dx.doi.org/10.1097/GME.0000000000001339DOI Listing
April 2019
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Sexual frequency and pain in a randomized clinical trial of vaginal estradiol tablets, moisturizer, and placebo in postmenopausal women.

Menopause 2019 Apr 15. Epub 2019 Apr 15.

Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.

Objective: To evaluate the efficacy of two common interventions for bothersome postmenopausal vaginal symptoms on improving sexual frequency and pain.

Methods: This is a post-hoc analysis of data from a 12-week double-blind placebo-controlled trial that randomized postmenopausal women (ages 45-70 years) with moderate-severe genitourinary discomfort to vaginal 10 μg estradiol tablet plus placebo gel (n = 102), placebo tablet plus vaginal moisturizer (n = 100), or dual placebo (n = 100). Outcomes were proportion of sexually active women at 12 weeks, frequency of sexual activity, and pain severity with sexual activity (0-3 scale). Read More

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http://dx.doi.org/10.1097/GME.0000000000001341DOI Listing
April 2019
2 Reads

Chronic pain and menopausal symptoms.

Authors:
Robin J Bell

Menopause 2019 Apr 15. Epub 2019 Apr 15.

Women's Health Research Program, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1097/GME.0000000000001331DOI Listing
April 2019
2 Reads

Partner status moderates the relationships between sexual problems and self-efficacy for managing sexual problems and psychosocial quality-of-life for postmenopausal breast cancer survivors taking adjuvant endocrine therapy.

Menopause 2019 Apr 15. Epub 2019 Apr 15.

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC.

Objective: Past studies indicate that >90% of breast cancer survivors taking adjuvant endocrine therapy (AET) experience menopausal symptoms including sexual problems (eg, vaginal dryness, dyspareunia); however, research examining the impact of these problems on quality-of-life is limited. This cross-sectional study examined (1) the impact of sexual problems and self-efficacy for coping with sexual problems (sexual self-efficacy) on quality-of-life (ie, psychosocial quality-of-life and sexual satisfaction), and (2) partner status as a moderator of these relationships.

Methods: Postmenopausal breast cancer survivors taking AET completed measures of sexual problems (Menopause-Specific Quality-of-Life [MENQOL] sexual subscale], sexual self-efficacy, psychosocial quality-of-life (MENQOL psychosocial subscale), and sexual satisfaction (Functional Assessment of Cancer Therapy-General item). Read More

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http://dx.doi.org/10.1097/GME.0000000000001337DOI Listing
April 2019
3 Reads

Letter to the Editor.

Menopause 2019 Apr 15. Epub 2019 Apr 15.

Department of Female Pelvic Medicine and Reconstructive Surgery, The Christ Hospital, Cincinnati, OH.

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http://dx.doi.org/10.1097/GME.0000000000001345DOI Listing
April 2019
2 Reads

Letters to the Editor.

Menopause 2019 Apr 15. Epub 2019 Apr 15.

Hospital Universitario San Jorge, Periera, Colombia Department of Gynecology, Ospedale San Raffaele, Milan, Italy Urogynecology Unit, Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Athens, Greece Department of Obstetrics and Gynecology, Diatros Barcelona, Barcelona, Spain Cosmetic Gynecology and General Surgery, Universidad de Buenos Aires Secretaria de Ciencia y Tecnica, Buenos Aires, Argentina Clinica de Gineco Endocrino, Complejo Hospitalario Metropolitano Caja Seguro Social Panama, Panama Nidad de Ginecoestitica Laser Madrid Spain, Madrid, Spain Department of Surgical and Morphological Studies, Universita degli Studi dell'Insubria, Varese, Italy Academia Nacional de Medicina Colombia, Bogota, Colombia.

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http://dx.doi.org/10.1097/GME.0000000000001346DOI Listing
April 2019
2 Reads

Conservative management of endometrial intraepithelial neoplasia in a patient with cirrhosis undergoing orthotopic liver transplant.

Menopause 2019 Apr 15. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, IL.

Objective: The aim of the study was to review the management of endometrial hyperplasia in a woman undergoing liver transplantation for alcoholic cirrhosis.

Methods: This is a case presentation on a postmenopausal woman with a tissue diagnosis of endometrial intraepithelial neoplasia managed with a levonorgestrel intrauterine device, before and after liver transplantation. Full written informed consent was obtained from the patient to present her case. Read More

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http://dx.doi.org/10.1097/GME.0000000000001342DOI Listing
April 2019
1 Read

Confirmatory factor analysis of the Insomnia Severity Index (ISI) and invariance across race: a pooled analysis of MsFLASH data.

Menopause 2019 Apr 15. Epub 2019 Apr 15.

School of Nursing, Indiana University, Indianapolis, IN.

Objective: Women's sleep at menopause is widely reported to be problematic. The Insomnia Severity Index (ISI) is a commonly used tool for quantifying sleep problems in clinical and research settings, but psychometric properties in postmenopausal women have not been reported. Our study aim was to examine the factor structure of the ISI in a large and diverse sample of midlife women with hot flashes. Read More

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http://dx.doi.org/10.1097/GME.0000000000001343DOI Listing
April 2019
2 Reads

Searching for Risk of Atrial Fibrillation in Surgical Early Menopause: Assessment of the Electromechanical Property and Function of the Left Atrium.

Authors:
Ran Heo

J Cardiovasc Imaging 2019 Apr;27(2):147-149

Division of Cardiology, Department of Internal Medicine, Hanyang University Medical Center, College of Medicine, Hanyang University, Seoul, Korea.

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http://dx.doi.org/10.4250/jcvi.2019.27.e25DOI Listing
April 2019
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Evaluation of Left Atrial Electromechanical Delay and Left Atrial Phasic Functions in Surgical Early Menopause Patients.

J Cardiovasc Imaging 2019 Apr;27(2):137-146

Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.

Background: This study evaluated the atrial electromechanical delay (AEMD) and the left atrial (LA) mechanical functions in patients with surgical early menopause.

Methods: A total of 62 patients were included in the study: 33 patients with surgical early menopause and 29 age- and sex-matched healthy controls. The duration distance from the start of the P wave to the beginning of the A wave for the lateral mitral annulus, septal mitral annulus, and lateral tricuspid annulus was assessed by tissue Doppler echocardiography. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.4250/jcvi.2019.2
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http://dx.doi.org/10.4250/jcvi.2019.27.e22DOI Listing
April 2019
2 Reads

Activation profiles of monocyte-macrophages and HDL function in healthy women in relation to menstrual cycle and in polycystic ovary syndrome patients.

Endocrine 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, University of Padova, Padova, Italy.

Purpose: Hormonal status and menopause affect human macrophage function and cardiometabolic risk. In polycystic ovary syndrome (PCOS) patients the cardiometabolic risk increases through mechanisms that are largely unknown. We tested the hypotheses that macrophage activation is influenced by menstrual cycle and that ovarian dysfunction in PCOS patients is associated with altered macrophage inflammatory responses and cholesterol efflux capacity of serum HDL. Read More

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http://dx.doi.org/10.1007/s12020-019-01911-2DOI Listing
April 2019
1 Read

Interaction Effect Between Breast Density and Reproductive Factors on Breast Cancer Risk in Korean Population.

J Cancer Prev 2019 Mar 30;24(1):26-32. Epub 2019 Mar 30.

Department of Medicine, Hanyang University College of Medicine, Seoul, Korea.

Background: This study was conducted to explore the effect of known risk factors, focusing on risk factors including age at menarche, age at menopause, number of children, family history of breast cancer, and age at first birth according to breast density, in consideration of interaction among East-Asian women.

Methods: Case-control study with 2,123 cases and 2,121 controls with mammographic density was conducted. Using the mammographic film, breast density was measured using Breast Imaging-Reporting and Data System. Read More

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http://dx.doi.org/10.15430/JCP.2019.24.1.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453588PMC
March 2019
1 Read

Estrogen-Dependent Functional Spine Dynamics in Neocortical Pyramidal Neurons of the Mouse.

J Neurosci 2019 Apr 16. Epub 2019 Apr 16.

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 916 Hunterian Building, 725 N. Wolfe Street, Baltimore, MD, 21205, USA

Surgical ovariectomy has been shown to reduce spine density in hippocampal CA1 pyramidal cells of rodents, and this reduction is reversed by 17β-estradiol (E2) treatment in a model of human estrogen replacement therapy. Here, we report reduction of spine density in apical dendrites of layer 5 pyramidal neurons of several neocortical regions that is reversed by subsequent E2 treatment in ovariectomized (OVX) female Thy1M-EGFP mice. We also found that OVX-associated reduction of spine density in somatosensory cortex was accompanied by a reduction in mEPSC frequency (but not mIPSC frequency), indicating a change in functional synapses. Read More

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.2772-1
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http://dx.doi.org/10.1523/JNEUROSCI.2772-18.2019DOI Listing
April 2019
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Effects of Pilates on fall risk factors in community-dwelling elderly women: A randomized, controlled trial.

Eur J Sport Sci 2019 Apr 16:1-9. Epub 2019 Apr 16.

a Department of Health Sciences, Faculty of Health Sciences , University of Jaén , Jaén , Spain.

Objective: the main objective was to analyze the effects that an exercise programme based on the Pilates method would have on balance confidence, fear of falling, and postural control among women ≥60 years old.

Methods: a total of 110 women (69.15 ± 8. Read More

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http://dx.doi.org/10.1080/17461391.2019.1595739DOI Listing
April 2019
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Evaluation of the Association between Menstrual Cycle Irregularity and Dental Pain or Chewing Discomfort in Women before Menopause.

J Clin Med 2019 Apr 4;8(4). Epub 2019 Apr 4.

Department of Periodontics, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

This study was performed to assess the relationship between menstrual irregularity and dental pain or chewing discomfort in women before menopause, using nationally representative data. This study analyzed 4595 participants who were ≥19 years or older, and did not have missing values for outcome variables from the Korean National Health and Nutrition Examination Survey. Tooth pain was considered present if the participant felt throbbing discomfort, pain, or sensitivity when eating hot or cold food or drinking hot or cold beverages. Read More

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http://dx.doi.org/10.3390/jcm8040454DOI Listing
April 2019
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Influence of Sex, Menstrual Cycle, and Menopause Status on the Exercise Pressor Reflex.

Med Sci Sports Exerc 2019 May;51(5):874-881

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.

In this review, we highlight the underlying mechanisms responsible for the sex differences in the exercise pressor reflex (EPR), and, importantly, the impact of sex hormones and menopausal status. The EPR is attenuated in premenopausal women compared with age-matched men. Specifically, activation of the metaboreflex (a component of the EPR) results in attenuated increases in blood pressure and sympathetic vasomotor outflow compared with age-matched men. Read More

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http://dx.doi.org/10.1249/MSS.0000000000001877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467496PMC
May 2019
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Update on Management of Polycystic Ovarian Syndrome for Dermatologists.

Indian Dermatol Online J 2019 Mar-Apr;10(2):97-105

Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Polycystic ovarian syndrome (PCOS) is the commonest endocrine disorder in women having wide range of clinical manifestation. These women may present with reproductive, dermatological, metabolic, psychological, or neoplastic implications from adolescence to menopause. The common dermatological manifestations include hirsutism, acne, alopecia, or acanthosis nigricans. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_249_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434760PMC

Vaginal dryness: individualised patient profiles, risks and mitigating measures.

EPMA J 2019 Mar 2;10(1):73-79. Epub 2019 Mar 2.

9Radiological clinic, UKB, Rheinische Friedrich-Wilhelms-University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.

Vaginal dryness (VD) affects both pre- and postmenopausal women at any age. Since the hormonal regulation changes during the climacteric period are considered as being the main course of the VD, affected women prefer not to talk about the problem. However, the problem does exist, and unfortunately if any, relatively minor group in the population possesses the health literacy at sufficient level to understand that VD is a suboptimal health condition which carries a multi-factorial character. Read More

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http://link.springer.com/10.1007/s13167-019-00164-3
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http://dx.doi.org/10.1007/s13167-019-00164-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459457PMC
March 2019
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Low Evolutionary Selection Pressure in Senescence Does Not Explain the Persistence of Aβ in the Vertebrate Genome.

Front Aging Neurosci 2019 28;11:70. Epub 2019 Mar 28.

Genetics and Aging Research Unit, Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Harvard Medical School - Massachusetts General Hospital, Boston, MA, United States.

The argument is frequently made that the amyloid-β protein (Aβ) persists in the human genome because Alzheimer's disease (AD) primarily afflicts individuals over reproductive age and, therefore, there is low selective pressure for the peptide's elimination or modification. This argument is an important premise for AD amyloidosis models and therapeutic strategies that characterize Aβ as a functionless and intrinsically pathological protein. Here, we review if evolutionary theory and data on the genetics and biology of Aβ are consistent with low selective pressure for the peptide's expression in senescence. Read More

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http://dx.doi.org/10.3389/fnagi.2019.00070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447958PMC
March 2019
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Summer-Associated Dermatitis: A Cross-Sectional Study of a Unique Eczematous Dermatosis in South India.

Indian J Dermatol 2019 Mar-Apr;64(2):136-142

Department of Dermatology, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India.

Background: In our hospital setup located in the tropical zone, during each summer, we frequently come across a unique eczematous dermatosis among elderly females that typically occur in summer.

Aims And Objectives: We carried out this study with the objective of studying the demographic and clinical features of this dermatosis.

Materials And Methods: In this hospital-based descriptive study, we enrolled twenty consecutive patients presenting with typical features of the dermatosis of interest, such as itchy eczematous scaly papule and plaques distributed predominantly over flexures, self-limiting in nature, and with summer exacerbation. Read More

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http://www.e-ijd.org/text.asp?2019/64/2/136/254169
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http://dx.doi.org/10.4103/ijd.IJD_668_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440175PMC
April 2019
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Conception rates and contraceptive use after bariatric surgery among women with infertility: Evidence from a prospective multicenter cohort study.

Surg Obes Relat Dis 2019 Jan 11. Epub 2019 Jan 11.

National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.

Background: Lack of prospective trials have resulted in a dearth of information regarding postbariatric surgery conception rates in women with a preoperative history of infertility.

Objective: To examine associations between preoperative history of infertility and postbariatric surgery conception.

Setting: A multicenter cohort study at 10 United States hospitals (2006-2009). Read More

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http://dx.doi.org/10.1016/j.soard.2018.12.026DOI Listing
January 2019
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[Sex and gender-specific aspects in prediabetes and diabetes mellitus-clinical recommendations (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Interne Abteilung, Landeskrankenhaus Hochzirl - Natters, Hochzirl, Österreich.

Metabolic diseases dramatically affect the life of men and women from infancy up to old age in different and manifold ways and are a major challenge for the healthcare system. The treating physicians are confronted with the different needs of women and men in the clinical routine. Gender-specific differences affect screening, diagnostic and treatment strategies as well as the development of complications and mortality rates. Read More

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http://dx.doi.org/10.1007/s00508-018-1421-1DOI Listing
April 2019
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Top studies relevant to primary care from 2018: From PEER.

Can Fam Physician 2019 Apr;65(4):260-263

Director of Programs and Practice Support for the College of Family Physicians of Canada and Professor in the Department of Family Medicine at the University of Alberta.

Objective: To summarize high-quality studies for 10 topics from 2018 that have strong relevance to primary care practice.

Quality Of Evidence: Study selection involved routine literature surveillance by a group of primary care health professionals. This included screening abstracts of important journals and Evidence Alerts, as well as searching . Read More

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April 2019
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Zoledronic acid combined with percutaneous kyphoplasty in the treatment of osteoporotic compression fracture in a single T12 or L1 vertebral body in postmenopausal women.

Osteoporos Int 2019 Apr 11. Epub 2019 Apr 11.

Department of Rheumatology, Changhai Hospital, Shanghai, China.

We performed a 1-year prospective study to see whether zoledronic acid infusion combined with percutaneous kyphoplasty could provide more benefits in the treatment of T12 or L1 osteoporotic vertebral compression fracture (OVCF).

Introduction: To investigate and analyze the clinical effects of zoledronic acid (ZOL) in combination with percutaneous kyphoplasty (PKP) in the treatment of OVCF in postmenopausal women.

Methods: Included in this study were 101 postmenopausal women patients with T12 or L1 OVCF who received PKP in our hospital between August 2015 and July 2017. Read More

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http://dx.doi.org/10.1007/s00198-019-04896-wDOI Listing
April 2019
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