Search Our Scientific Publications & Authors

Hum Brain Mapp 2018 Dec 12. Epub 2018 Dec 12.

Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Research on age-related memory alterations traditionally targets individuals aged ≥65 years. However, recent studies emphasize the importance of early aging processes. We therefore aimed to characterize variation in brain gray matter structure in early midlife as a function of sex and menopausal status. Read More

Clin Endocrinol (Oxf) 2018 Dec 12. Epub 2018 Dec 12.

Department of Physiology, Monash University, Melbourne, Victoria, Australia.

Objective: Polycystic ovary syndrome (PCOS) is associated with increased obesity with a greater propensity to weight gain and a lack of sustainable lifestyle interventions. Altered brown adipose tissue (BAT) thermogenesis is a potential contributor to obesity in PCOS. BAT activity and modulation has not been studied in PCOS. Read More

J Obstet Gynaecol Res 2018 Dec 12. Epub 2018 Dec 12.

1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.

Aim: Endometrial biopsy is one of the most commonly performed gynecological procedures. Apart from patient safety, the most important is to obtain an adequate specimen allowing histopathological diagnosis. The aim of the study was to determine the rate of endometrial sampling failure and factors affecting the quality of specimen obtained for histopathological examination among patients who underwent Pipelle biopsy and dilatation and curettage (D&C). Read More

Biol Sex Differ 2018 Dec 14;9(1):52. Epub 2018 Dec 14.

Division of Cardiology, Korea University Medical Center, Anam hospital, Seoul, South Korea.

Background: Evidence suggests that epicardial adipose tissue (EAT) is closely related to coronary artery stenosis (CAS). However, sexual dimorphism may be present in adipose tissue, and its influence on CAS between men and women is controversial. We assessed the relationship between EAT and CAS by sex and menopausal status in patients with suspected angina. Read More

Primates 2000 Jul;41(3):311-319

Center for Reproduction of Endangered Species, Zoological Society of San Diego, P. O. Box 120551, 92122, San Diego, California, USA.

Urinary and fecal hormones were analyzed on average every other day in 17 female bonobos kept at four US zoos (San Diego Zoo and Wild Animal Park, Milwaukee, Columbus, and Cincinnati). Ovarian cycle activity was monitored throughout the 15-month study period using estrogen and progesterone profiles and swelling charts. Behavioral data on sexual activity were also collected on a daily basis. Read More

Geroscience 2018 Dec 13. Epub 2018 Dec 13.

Department of Animal, Dairy and Veterinary Sciences, Center for Integrated BioSystems, School of Veterinary Medicine, Utah State University, 4700 Old Main Hill, Logan, UT, 84322, USA.

Cardiovascular disease, rare in premenopausal women, increases sharply at menopause and is typically accompanied by chronic inflammation. Previous work in our laboratory demonstrated that replacing senescent ovaries in post-reproductive mice with young, actively cycling ovaries restored many health benefits, including decreased cardiomyopathy and restoration of immune function. Our objective here was to determine if depletion of germ cells from young transplanted ovaries would alter the ovarian-dependent extension of life and health span. Read More

Pathologica 2018 Sep;110(2):92-95

Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Azienda Ospedaliero-Universitaria "Policlinico-Vittorio Emanuele", Anatomic Pathology Section, School of Medicine, University of Catania, Italy.

Intestinal-type adenocarcinoma is a rare primary vaginal carcinoma and considerably more uncommon than metastatic lesions which represent the most frequent malignancy at this anatomic site. Among all malignant tumors, colorectal, breast and female genital tract carcinomas have the tendency to metastasize to the vagina.

As morphologic and immunohistochemical features of intestinal-type adenocarcinoma occurring primarily in the vagina are not specific, clinical and radiologic information is crucial to exclude a metastatic lesion. Read More

Reprod Sci 2018 Dec 13:1933719118812730. Epub 2018 Dec 13.

1 Department of Biology, McMaster University, Hamilton, Canada. Santosh Jagadeeshan is now with the Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada.

Maternal mortality remains one of the leading causes of death in women of reproductive age in developing countries, and a major concern in some developed countries. It is puzzling why such a condition has not been reduced in frequency, if not eliminated, in the course of evolution. Maternal mortality is a complex phenomenon caused by several physiological and physical factors. Read More

Brain Sci 2018 Dec 7;8(12). Epub 2018 Dec 7.

Departamento de Ciencias Médicas, Universidad de Guanajuato, León, Guanajuato 37320, Mexico.

Polymorphisms of the estrogen receptor and genes have been linked with cognitive deficits and affective disorders. The effects of these genetic variants on emotional processing in females with low estrogen levels are not well known. The aim was to explore the impact of the and genes on the responses to the facial emotion recognition task in females. Read More

Int J Epidemiol 2018 Dec 13. Epub 2018 Dec 13.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.

Background: Studies disagree as to whether intakes of folate-mediated one-carbon metabolism nutrients are associated with endometrial cancer.

Methods: Using data from the large, prospective NIH-AARP Diet and Health Study, we used Cox proportional hazards models to evaluate endometrial cancer risk associated with calorie-adjusted dietary intake of several B vitamins and methionine. All models accounted for age, race, body mass index (BMI), smoking, oral-contraceptive use, menopausal hormone therapy use and caloric intake. Read More

Occup Med (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Division of Psychiatry and Applied Psychology, School of Medicine, Institute of Mental Health, University of Nottingham Innovation Park, Triumph Road, Nottingham, UK.

Background: Recent evidence suggests that some women experience menopausal symptoms that impact on their working lives, and that work environments can impact upon the experience of menopause. As a result, guidance for employers and other key stakeholders about this potential occupational health issue has emerged. To date there has not been a review of these documents to identify their main recommendations for policy and practice. Read More

Acta Neurol Belg 2018 Dec 12. Epub 2018 Dec 12.

Midwifery Department, Menopause Andropause Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

This study aimed to assess the relationship between RLS and medical problems among pregnant women. In this study, 700 pregnant women were recruited. A socio-demographic questionnaire and the International Restless Legs Questionnaire were used to gather information. Read More

F1000Res 2018 22;7. Epub 2018 Nov 22.

Monash Health, Clayton, VIC, Australia.

Female fertility decreases with increasing age, a reflection of declining oocyte quantity and quality. The menopausal transition occurs when the oocyte quantity falls below a threshold level. The pattern of follicular depletion as well as the factors, timing and mechanisms surrounding both declining oocyte number and oocyte quality remain incompletely understood. Read More

Front Genet 2018 27;9:529. Epub 2018 Nov 27.

Sheba Medical Center, Tel Hashomer and Tel Aviv University, Tel Aviv, Israel.

Abnormalities in the X-linked gene are associated with a constellation of disorders, which have broad and profound implications for the person first diagnosed, and extended family members of all ages. The rare and pleiotropic nature of the associated disorders, both common and not, place great burdens on (1) the affected families, (2) their care providers and clinicians, and (3) investigators striving to conduct research on the conditions. Fragile X syndrome, occurring more severely in males, is the leading genetic cause of intellectual disability. Read More

Endocrinol Diabetes Nutr 2018 Dec 9. Epub 2018 Dec 9.

Scientific Direction, Gador SA, Buenos Aires, Argentina.

Background: Almeria is a region in southeast Spain with optimal sunlight levels, along with low pluvial and pollution rates. If exposure to sunlight is sufficient to maintain adequate levels of vitamin D (25OHD), this population should display high serum levels.

Objectives: To describe 25OHD serum status in women from Almeria and evaluate the impact of long sunlight exposure along the seasons on 25OHD. Read More

BMC Cancer 2018 Dec 12;18(1):1246. Epub 2018 Dec 12.

Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Diabetes mellitus (DM) is associated with poorer outcomes in some cancers. Its effect on ovarian cancer is less clear. We consider the effect of DM on overall survival (OS) and progression free survival (PFS) in patients with epithelial ovarian cancer (EOC). Read More

Reprod Sci 2018 Dec 12:1933719118818906. Epub 2018 Dec 12.

1 Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China.

To evaluate the effect of ovarian biopsy and scratch on the resumption of ovarian function in women with premature ovarian insufficiency (POI), the follicle development and pregnancy outcome were retrospectively analyzed in women with POI after ovarian biopsy/scratch. Eighty patients with POI with secondary amenorrhea were accepted the laparoscopic surgery, and then hormone replacement treatment for 6 months was applied and in vitro fertilization and embryo transfer was suggested. No significant difference in clinical characteristics was observed before and after ovarian biopsy/scratch ( P > . Read More

Sports Med Int Open 2017 Aug 6;1(5):E166-E171. Epub 2017 Sep 6.

Kinesiology, University of San Francisco, San Francisco, United States.

Postmenopausal women have an increased risk for cardiovascular disease through many factors, such as a sedentary lifestyle and reduced heart rate variability (HRV). Endurance training improves coronary risk but the role of exercise intensity is unclear. The purpose of this observational study was to evaluate the effects of moderate versus vigorous exercise on cardiovascular disease risk in postmenopausal women. Read More

Oxid Med Cell Longev 2018 5;2018:1752940. Epub 2018 Nov 5.

Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.

Paraoxonase-1 (PON1) and lipoprotein phospholipase A2 (Lp-PLA2) may exert an important protective role by preventing the oxidative transformation of high- and low-density lipoproteins (HDL and LDL, respectively). The activity of both enzymes is influenced by lipidome and proteome of the lipoprotein carriers. T2DM typically presents significant changes in the molecular composition of the lipoprotein subclasses. Read More

Front Endocrinol (Lausanne) 2018 22;9:698. Epub 2018 Nov 22.

Weill Cornell Medical College Qatar, Doha, Qatar.

The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action. We examined the effect of soy isoflavones on reverse tri-iodothyronine (or 3,3',5'-tri-iodothyronine; rT) in two studies comprising 400 patients: 200 men (study 1; 3 months) and 200 post-menopausal women (study 2; 6 months) who were randomized to consume 15 g soy protein with 66 mg of isoflavones (SPI) daily, or 15 g soy protein alone without isoflavones (SP) daily. SPI supplementation increased rT serum concentration in both men 0. Read More

Front Pharmacol 2018 16;9:1314. Epub 2018 Nov 16.

Department of Anatomy, College of Korean Medicine, Kyung Hee University, Seoul, South Korea.

(BF) extract, a natural product with anti-inflammatory properties, has been traditionally used to treat menopausal symptoms, but its role in osteoporosis, another serious health concern of menopausal women, remains unknown. Here we investigated whether and how BF prevents estrogen deficiency-induced bone loss using both and models. Female Sprague-Dawley rats were ovariectomized (OVX) and subjected to oral BF treatment daily for 8 weeks. Read More

Med Arch 2018 Nov;72(5):335-340

Clinic for General and Abdominal Surgery, Clinical Center University of Sarajevo, Bosnia and Herzegovina.

Introduction: Breast cancer is the most common malignant tumor in women. On the list of causes of death immediately after lung cancer. It is a heterogeneous disease, considering the differences in morphological, cytogenetic, molecular, clinical and therapeutic aspects, so that the prognosis in a patient with the same histological grade and pathological status may vary. Read More

Int Urogynecol J 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics and Gynecology, The American University of Beirut, Beirut, Lebanon.

This committee opinion reviews the laser-based vaginal devices for treatment of genitourinary syndrome of menopause, vaginal laxity, and stress urinary incontinence. The United States Food and Drug Administration has issued a warning for unsubstantiated advertising and use of energy-based devices. Well-designed case-control studies are required to further investigate the potential benefits, harm, and efficacy of laser therapy in the treatment of genitourinary syndrome of menopause, vaginal laxity, and stress urinary incontinence. Read More

PLoS One 2018 12;13(12):e0207885. Epub 2018 Dec 12.

Departments of Pharmacology and Neurology, College of Medicine, University of Arizona, Tucson, United States of America.

Two thirds of all persons with late-onset Alzheimer's disease (AD) are women. Identification of sex-based molecular mechanisms underpinning the female-based prevalence of AD would advance development of therapeutic targets during the prodromal AD phase when prevention or delay in progression is most likely to be effective. This 3-year brain imaging study examines the impact of the menopausal transition on Alzheimer's disease (AD) biomarker changes [brain β-amyloid load via 11C-PiB PET, and neurodegeneration via 18F-FDG PET and structural MRI] and cognitive performance in midlife. Read More

Cancer Causes Control 2018 Dec 11. Epub 2018 Dec 11.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-C308, Seattle, WA, 98109, USA.

Purpose: In situ breast cancer patients have a higher risk of developing a second primary breast cancer than women in the general population have of developing breast cancer. We have limited understanding of why some women with a previous in situ breast cancer develop second primary breast cancers while others do not.

Methods: In this population-based nested case-control study, we evaluated the association between reproductive and menopausal factors and risk of developing a second primary breast cancer among women with a previous in situ breast cancer. Read More

Drugs Today (Barc) 2018 Nov;54(11):667-677

Professor Emeritus of Pharmacology, University of Auckland, Auckland, New Zealand.

Many women suffer from the genitourinary syndrome of the menopause (GSM), in particular pathological changes that occur in the vagina due to the reduction in their production of estrogens. TherapeuticsMD has developed Imvexxy, small softgel capsules that contain solubilized estradiol and that are inserted vaginally by women twice a week, every 3 to 4 days. These vaginal inserts have been found to readily supply estradiol to the vagina and to result in significant improvement in the GSM signs and symptoms these women had been experiencing. Read More

Virusdisease 2018 Dec 3;29(4):537-539. Epub 2018 Aug 3.

1Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, 576104 Karnataka India.

Once the recommended 5-year recurrence-free follow-up is achieved for cervical cancers regular annual pelvic examination is mandatory. The main aim of presenting this short report is to emphasize the difficulties in the collection and interpretation of cytology samples from stenosed cervix or vault after pelvic irradiation. Radiotherapy can induce changes in the cellular morphology which may persist for many years. Read More

Int J Womens Health 2018 21;10:745-750. Epub 2018 Nov 21.

Università degli studi di Salerno - Dipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana", Salerno, Italy,

Objective: This paper reports on a rare case of pregnancy after uterine artery embolization (UAE) for uterine arteriovenous malformation (AVM). Debate exists about persistence of fertility in women after UAE. Adverse effects of this technique can modify both uterine echostructure, inducing necrosis and infarction, endometrial atrophy and uterine artery rupture, and ovarian reserve, causing persistent amenorrhea. Read More

J Cardiol Cases 2013 Apr 17;7(4):e104-e108. Epub 2013 Jan 17.

Division of Cardiology, Department of Internal Medicine, Tungs' Taichung MetroHarbor Hospital, No. 699, Sec. 1, Chungchi Rd., Wuchi, Taichung 43503, Taiwan.

Stress cardiomyopathy (SCM) is a syndrome of transient cardiac abnormalities precipitated by intense emotional or physical stress. Differentiating SCM from acute myocardial infarction is often difficult but vital to avoid subjecting SCM patients to unnecessary reperfusion therapy and invasive coronary angiography. For accurate diagnosis, it is important that physicians be familiar with the current diagnostic criteria, most susceptible populations, and typical triggers for SCM. Read More

J Bone Miner Res 2018 Dec 7. Epub 2018 Dec 7.

East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Department of orthopedic oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.

Osteoporosis is a global bone disease characterized by reduced bone mineral density (BMD) and increased risk of fractures. The risk of developing osteoporosis increases with aging, especially after menopause in women. Discovering the signaling pathways which play a significant role in aging- and menopause-induced osteoporosis should accelerate osteoporosis drug discovery. Read More

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Physiology, Faculty of Medicine, Minia University, Minia, Egypt.

Cerebellum seems to be a specific target for both the decrease of estrogen and hypertension in menopause. The aim of this study was to investigate the hypertension and menopause-induced changes in rat's cerebellar cortex and the possible mechanisms of these changes. Rats were divided into four groups: the sham-operated control (SC-group), the ovariectomized (OVX-group), the hypertensive (H-group), and the ovariectomized-hypertensive (OVX-H-group) group. Read More

Exp Clin Endocrinol Diabetes 2018 Dec 10. Epub 2018 Dec 10.

Graduate Program in Nutrition Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre Porto Alegre, RS, Brazil.

Background And Aims: The main aim of this study was to analyze how the lipid accumulation affects the whole-body fat oxidation over a range of intensities during a submaximal incremental exercise test in post-menopausal overweight-obese women.

Patients And Methods: The maximal fat oxidation (MFO), the intensity where the MFO occurs (FatMax), fat oxidation were measured over a range of intensities during a submaximal incremental exercise test through indirect calorimetry in 60 postmenopausal overweight-obese women (aged>49 years; body mass index 28.0 to 39. Read More

Int Urogynecol J 2018 Dec 10. Epub 2018 Dec 10.

Department of General Gynecology and Gynecologic Oncology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Introduction And Hypothesis: Abnormalities of connective tissue structure or its repair mechanism may predispose women to pelvic organ prolapse (POP). We hypothesized that the expression of tenascin-X in the uterosacral ligament of postmenopausal women with symptomatic POP is increased compared with postmenopausal women without POP. Furthermore, we identified clinical risk factors associated with POP in our study population. Read More

Methods Mol Biol 2019 ;1916:303-309

Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo, Diadema, SP, Brazil.

Estrogen and ovarian function decline are relevant characteristics of menopause period. Numerous physiological, metabolic and immunological alterations in the female body occur in the menopause period and some of these changes remain uncertain. The animal model that mimics menopause phase is an important approach to better comprehend the biological process involved in this period of women life. Read More

Endocrinology 2019 Jan;160(1):1-19

Department of Psychology, Arizona State University, Tempe, Arizona.

Approximately one-third of women experience hysterectomy, or the surgical removal of the uterus, by 60 years of age, with most surgeries occurring prior to the onset of natural menopause. The ovaries are retained in about half of these surgeries, whereas for the other half hysterectomy occurs concurrently with oophorectomy. The dogma is that the nonpregnant uterus is dormant. Read More

Am J Clin Nutr 2018 Sep;108(3):502-516

Departments of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut, Karlsruhe, Germany.

Background: Although sugars and sugar derivatives are an important class of metabolites involved in many physiologic processes, there is limited knowledge on their occurrence and pattern in biofluids.

Objective: Our aim was to obtain a comprehensive urinary sugar profile of healthy participants and to demonstrate the wide applicability and usefulness of this sugar profiling approach for nutritional as well as clinical studies.

Design: In the cross-sectional KarMeN study, the 24-h urine samples of 301 healthy participants on an unrestricted diet, assessed via a 24-h recall, were analyzed by a newly developed semitargeted gas chromatography-mass spectrometry (GC-MS) profiling method that enables the detection of known and unknown sugar compounds. Read More

Indian J Psychol Med 2018 Nov-Dec;40(6):574-576

Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

The connection between menstruation and psychosis has been recognized since the 18 Century. However, there are few case reports available in modern times describing about 30 patients with this condition. The psychosis may occur in the premenstrual phase in some patients and in others it begins with the onset of menses. Read More

Gac Med Mex 2018 ;154(6):645-648

Hospital de Oncología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.

Introduction: Cardiovascular disease is the main cause of mortality worldwide. In women, its incidence increases at the sixth decade of life, coinciding with postmenopause. Whether this effect is due to menopause-related hormonal changes is not known. Read More

Gac Med Mex 2018 ;154(6):638-644

Secretaría de Salud, Hospital General de México, Departamento de Medicina Interna. Ciudad de México, México.

Introduction: Cardiovascular disease is the main cause of mortality worldwide. In women, its incidence increases at the sixth decade of life, coinciding with postmenopause. Whether this effect is due to menopause-related hormonal changes is not known. Read More

Med Sci Monit 2018 Dec 10;24:8950-8958. Epub 2018 Dec 10.

Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).

BACKGROUND This study analyzed the epidemiology and the risk factors of menopause syndrome (MPS) among Uyghur, Han, and Kazak women in Xinjiang. MATERIAL AND METHODS This was a cross-sectional study. The stratified-cluster random-sampling method was used. Read More

Med Sci Sports Exerc 2018 Dec 5. Epub 2018 Dec 5.

Department of Kinesiology, Kansas State University, Manhattan, KS.

Introduction: the aim of the current investigation was to examine if dietary nitrate supplementation would improve vascular control in hypertensive post-menopausal women (PMW). We tested the hypotheses that acute dietary nitrate supplementation would 1) significantly decrease arterial blood pressure (BP) at rest and during exercise; 2) increase limb blood flow during steady-state exercise; and 3) improve functional sympatholysis during steady-state (SS) exercise.

Methods: ten hypertensive PMW underwent a randomized, double-blind placebo-controlled trial with a nitrate-rich (NR) or nitrate poor (NP) supplement. Read More

Menopause 2018 Dec 10. Epub 2018 Dec 10.

Massachusetts General Hospital, Boston, MA.

Menopause 2018 Dec 10. Epub 2018 Dec 10.

Department of Obstetrics and Gynecology, State University of Campinas (UNICAMP - Universidade Estadual de Campinas), Campinas, São Paulo, Brazil.

Objective: To evaluate the effect of isoflavone administration, either in conjunction with probiotic use or not, on the symptoms of genitourinary syndrome of menopause, and compare the effects with those of hormone therapy.

Methods: A randomized clinical trial was conducted on 60 postmenopausal women aged 40 to 60 years, randomly assigned to receive oral isoflavone (150 mg dry extract of glycine max) alone or isoflavone plus probiotic (Lactobacillus acidophilus, Lactobacillus casei, Lactococcus lactis, Bifidobacterium bifidum, and Bifidobacterium lactis) or hormone therapy (1 mg estradiol and 0.5 mg norethisterone acetate). Read More

Menopause 2018 Dec 10. Epub 2018 Dec 10.

New England Research Institutes, Inc., Watertown, MA.

Objective: This study describes women's experiences of the genitourinary syndrome of menopause (GSM) elicited through focus groups and cognitive debriefing sessions during development of a novel patient-reported outcome measure (PROM) designed for use in both clinical care and research.

Methods: A draft questionnaire to identify and assess bothersome genitourinary symptoms associated with estrogen deficiency in menopausal women was developed in five discrete phases from multiple sources of information in accordance with standards for PROM development. GSM was confirmed by report of symptoms in conjunction with a confirmatory pelvic examination and laboratory assessments. Read More

Menopause 2018 Dec 10. Epub 2018 Dec 10.

School of Nursing, University of Washington, Seattle, WA.

Objective: The purpose of this study was to test the association of two dimensions of self-awareness with hot flash (HF) severity.

Methods: A subset of women from the Seattle Midlife Women's Health Study (N = 232) provided data for these analyses. Structural equation modeling was used to evaluate two dimensions of self-awareness (Internal States Awareness [ISA] and Self-Reflectiveness [SR]), and secondary factors of perceived stress, anxiety, and attitudes toward menopause as continuous with earlier life, health perceptions, and menopausal stage with respect to HF severity. Read More

Menopause 2018 Dec 10. Epub 2018 Dec 10.

Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, New Zealand.

Menopause 2018 Dec 10. Epub 2018 Dec 10.

Department of Reproductive Health, Student Research Committee, School of Nursing & Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: The present study was conducted to investigate the effect of a midwife-based counseling education program on sexual function in postmenopausal women.

Methods: A randomized clinical trial was conducted on 52 eligible postmenopausal women. Participants' sexual function was assessed using the Female Sexual Function Index (FSFI). Read More

Menopause 2018 Dec 10. Epub 2018 Dec 10.

College of Nursing & Ewha Research Institute of Nursing Science, Ewha Womans University Seodaemun-gu, Seoul, South Korea.

Objective: The purpose of this study was to explore factors influencing age of menopause among Korean women.

Methods: For this secondary analysis study, panel data for Waves 4 through 6 of the Korean Longitudinal Survey of Women were used. Women aged 40 to 60 who were menstruating at Wave 4 were included in the analysis (N = 5,437). Read More

Cancer Treat Rev 2018 Dec 1;72:65-77. Epub 2018 Dec 1.

Fertility Clinic, CUB-Hôpital Erasme and Research Laboratory on Human Reproduction, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium.

Survivorship issues are an area of crucial importance to be addressed as early as possible by all health care providers dealing with cancer patients. In women diagnosed during their reproductive years, the possible occurrence of chemotherapy-induced premature ovarian insufficiency (POI) is of particular concern being associated with important menopause-related symptoms, psychosocial issues as well as infertility. Temporary ovarian suppression by administering a gonadotropin-releasing hormone agonist (GnRHa) during chemotherapy has been studied to reduce the gonadotoxic impact of chemotherapy thus diminishing the chance of developing POI. Read More

Behav Brain Res 2018 Dec 7. Epub 2018 Dec 7.

Programa de Posgrado en Neuroetología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, Mexico; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, Mexico.

In woman, surgical menopause is associated with anxiety and depression symptoms. Ovariectomy in rats has been proposed as an experimental model of surgical menopause, but its long-term effects on anxiety- and depression-like behaviors and relationship with cellular changes in specific brain structures are unknown. The effects of ovariectomy on anxiety- and despair-like behavior 1, 3, 6, 9, 12, and 15-weeks postovariectomy were evaluated. Read More